FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3145, 354 aa 1>>>pF1KE3145 354 - 354 aa - 354 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0820+/-0.000446; mu= 18.4008+/- 0.028 mean_var=71.7751+/-13.957, 0's: 0 Z-trim(110.4): 88 B-trim: 273 in 1/52 Lambda= 0.151387 statistics sampled from 18688 (18780) to 18688 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.587), E-opt: 0.2 (0.22), width: 16 Scan time: 5.180 The best scores are: opt bits E(85289) NP_001095856 (OMIM: 139395) guanine nucleotide-bin ( 354) 2320 516.1 4.6e-146 XP_011539566 (OMIM: 139340,613856) PREDICTED: guan ( 354) 1940 433.1 4.4e-121 NP_005263 (OMIM: 139340,613856) guanine nucleotide ( 354) 1940 433.1 4.4e-121 XP_011514426 (OMIM: 139395) PREDICTED: guanine nuc ( 297) 1899 424.1 1.9e-118 NP_000163 (OMIM: 139330,610444,616389) guanine nuc ( 350) 1860 415.6 8e-116 NP_653082 (OMIM: 139330,610444,616389) guanine nuc ( 350) 1860 415.6 8e-116 NP_002061 (OMIM: 139360,192605) guanine nucleotide ( 355) 1697 380.1 4.2e-105 NP_002060 (OMIM: 139310) guanine nucleotide-bindin ( 354) 1685 377.4 2.6e-104 NP_006487 (OMIM: 139370,602483) guanine nucleotide ( 354) 1678 375.9 7.4e-104 NP_001159897 (OMIM: 139360,192605) guanine nucleot ( 318) 1562 350.5 2.9e-96 NP_001269548 (OMIM: 139360,192605) guanine nucleot ( 339) 1562 350.6 3e-96 NP_001269549 (OMIM: 139360,192605) guanine nucleot ( 339) 1562 350.6 3e-96 NP_001269546 (OMIM: 139360,192605) guanine nucleot ( 303) 1483 333.3 4.4e-91 NP_001243343 (OMIM: 139310) guanine nucleotide-bin ( 302) 1481 332.8 5.9e-91 NP_066268 (OMIM: 139311,615473) guanine nucleotide ( 354) 1470 330.5 3.5e-90 NP_620073 (OMIM: 139311,615473) guanine nucleotide ( 354) 1459 328.1 1.9e-89 NP_002064 (OMIM: 139160) guanine nucleotide-bindin ( 355) 1407 316.7 4.9e-86 NP_001269547 (OMIM: 139360,192605) guanine nucleot ( 274) 1334 300.7 2.5e-81 XP_011521305 (OMIM: 139311,615473) PREDICTED: guan ( 312) 1271 287.0 3.9e-77 NP_004288 (OMIM: 604397) guanine nucleotide-bindin ( 355) 1114 252.7 9e-67 NP_002063 (OMIM: 163000,185300,600998) guanine nuc ( 359) 1106 251.0 3e-66 NP_002058 (OMIM: 139313) guanine nucleotide-bindin ( 359) 1103 250.3 4.8e-66 XP_016870830 (OMIM: 604397) PREDICTED: guanine nuc ( 301) 954 217.7 2.6e-56 XP_016870117 (OMIM: 163000,185300,600998) PREDICTE ( 301) 949 216.6 5.6e-56 NP_031379 (OMIM: 604394) guanine nucleotide-bindin ( 381) 932 213.0 8.8e-55 XP_016884275 (OMIM: 139160) PREDICTED: guanine nuc ( 307) 911 208.3 1.8e-53 NP_002059 (OMIM: 139314) guanine nucleotide-bindin ( 374) 873 200.1 6.5e-51 NP_006563 (OMIM: 604406) guanine nucleotide-bindin ( 377) 869 199.2 1.2e-50 XP_011517526 (OMIM: 604397) PREDICTED: guanine nuc ( 237) 844 193.6 3.7e-49 NP_001070957 (OMIM: 102200,103580,139320,166350,17 ( 379) 825 189.6 9.5e-48 NP_536351 (OMIM: 102200,103580,139320,166350,17480 ( 380) 818 188.1 2.7e-47 NP_001135811 (OMIM: 139312,615073) guanine nucleot ( 381) 818 188.1 2.7e-47 NP_001248372 (OMIM: 139312,615073) guanine nucleot ( 381) 818 188.1 2.7e-47 XP_016883303 (OMIM: 102200,103580,139320,166350,17 (1022) 819 188.6 5e-47 NP_892023 (OMIM: 139312,615073) guanine nucleotide ( 458) 812 186.8 7.8e-47 XP_016883302 (OMIM: 102200,103580,139320,166350,17 (1023) 812 187.1 1.5e-46 XP_016883304 (OMIM: 102200,103580,139320,166350,17 ( 347) 763 176.1 1.1e-43 NP_001269370 (OMIM: 604394) guanine nucleotide-bin ( 322) 727 168.2 2.3e-41 XP_011513590 (OMIM: 604394) PREDICTED: guanine nuc ( 284) 726 167.9 2.4e-41 XP_016867497 (OMIM: 604394) PREDICTED: guanine nuc ( 253) 714 165.2 1.4e-40 XP_016883306 (OMIM: 102200,103580,139320,166350,17 ( 320) 678 157.5 3.8e-38 XP_016883308 (OMIM: 102200,103580,139320,166350,17 ( 320) 678 157.5 3.8e-38 XP_016883307 (OMIM: 102200,103580,139320,166350,17 ( 320) 678 157.5 3.8e-38 NP_001269354 (OMIM: 604406) guanine nucleotide-bin ( 282) 660 153.5 5.3e-37 XP_016883309 (OMIM: 102200,103580,139320,166350,17 ( 320) 648 150.9 3.6e-36 XP_016883305 (OMIM: 102200,103580,139320,166350,17 ( 320) 648 150.9 3.6e-36 NP_001296790 (OMIM: 102200,103580,139320,166350,17 ( 335) 648 150.9 3.7e-36 NP_001296769 (OMIM: 102200,103580,139320,166350,17 ( 335) 648 150.9 3.7e-36 NP_000507 (OMIM: 102200,103580,139320,166350,17480 ( 394) 648 151.0 4.2e-36 NP_001070956 (OMIM: 102200,103580,139320,166350,17 ( 395) 648 151.0 4.2e-36 >>NP_001095856 (OMIM: 139395) guanine nucleotide-binding (354 aa) initn: 2320 init1: 2320 opt: 2320 Z-score: 2743.3 bits: 516.1 E(85289): 4.6e-146 Smith-Waterman score: 2320; 100.0% identity (100.0% similar) in 354 aa overlap (1-354:1-354) 10 20 30 40 50 60 pF1KE3 MGSGISSESKESAKRSKELEKKLQEDAERDARTVKLLLLGAGESGKSTIVKQMKIIHKNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGSGISSESKESAKRSKELEKKLQEDAERDARTVKLLLLGAGESGKSTIVKQMKIIHKNG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 YSEQECMEFKAVIYSNTLQSILAIVKAMTTLGIDYVNPRSAEDQRQLYAMANTLEDGGMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YSEQECMEFKAVIYSNTLQSILAIVKAMTTLGIDYVNPRSAEDQRQLYAMANTLEDGGMT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 PQLAEVIKRLWRDPGIQACFERASEYQLNDSAAYYLNDLDRITASGYVPNEQDVLHSRVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQLAEVIKRLWRDPGIQACFERASEYQLNDSAAYYLNDLDRITASGYVPNEQDVLHSRVK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TTGIIETQFSFKDLHFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTGIIETQFSFKDLHFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEEV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 NRMHESLHLFNSICNHKYFSTTSIVLFLNKKDIFQEKVTKVHLSICFPEYTGPNTFEDAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRMHESLHLFNSICNHKYFSTTSIVLFLNKKDIFQEKVTKVHLSICFPEYTGPNTFEDAG 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 NYIKNQFLDLNLKKEDKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NYIKNQFLDLNLKKEDKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF 310 320 330 340 350 >>XP_011539566 (OMIM: 139340,613856) PREDICTED: guanine (354 aa) initn: 1940 init1: 1940 opt: 1940 Z-score: 2294.8 bits: 433.1 E(85289): 4.4e-121 Smith-Waterman score: 1940; 80.2% identity (94.6% similar) in 354 aa overlap (1-354:1-354) 10 20 30 40 50 60 pF1KE3 MGSGISSESKESAKRSKELEKKLQEDAERDARTVKLLLLGAGESGKSTIVKQMKIIHKNG :::: :.:.:: :::::::::::::::...:.:::::::::::::::::::::::::..: XP_011 MGSGASAEDKELAKRSKELEKKLQEDADKEAKTVKLLLLGAGESGKSTIVKQMKIIHQDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 YSEQECMEFKAVIYSNTLQSILAIVKAMTTLGIDYVNPRSAEDQRQLYAMANTLEDGGMT :: .::.::::.::.:.:::::::..:::::::::..: :.: ::: .:...:.: : XP_011 YSPEECLEFKAIIYGNVLQSILAIIRAMTTLGIDYAEPSCADDGRQLNNLADSIEEGTMP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 PQLAEVIKRLWRDPGIQACFERASEYQLNDSAAYYLNDLDRITASGYVPNEQDVLHSRVK :.:.:::.:::.: :.:::::::.::::::::.::::.:.::: :.:.:::::.:::: XP_011 PELVEVIRRLWKDGGVQACFERAAEYQLNDSASYYLNQLERITDPEYLPSEQDVLRSRVK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TTGIIETQFSFKDLHFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEEV :::::::.:: :::.::::::::::::::::::::::::::::::::::::::::::.:: XP_011 TTGIIETKFSVKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDDEV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 NRMHESLHLFNSICNHKYFSTTSIVLFLNKKDIFQEKVTKVHLSICFPEYTGPNTFEDAG :::::::::::::::::.:..:::::::::::.:.::. ::::::::::: : :...::: XP_011 NRMHESLHLFNSICNHKFFAATSIVLFLNKKDLFEEKIKKVHLSICFPEYDGNNSYDDAG 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 NYIKNQFLDLNLKKEDKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF ::::.::::::..:. :::::::::::::::::::::::::::::::::::::: XP_011 NYIKSQFLDLNMRKDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF 310 320 330 340 350 >>NP_005263 (OMIM: 139340,613856) guanine nucleotide-bin (354 aa) initn: 1940 init1: 1940 opt: 1940 Z-score: 2294.8 bits: 433.1 E(85289): 4.4e-121 Smith-Waterman score: 1940; 80.2% identity (94.6% similar) in 354 aa overlap (1-354:1-354) 10 20 30 40 50 60 pF1KE3 MGSGISSESKESAKRSKELEKKLQEDAERDARTVKLLLLGAGESGKSTIVKQMKIIHKNG :::: :.:.:: :::::::::::::::...:.:::::::::::::::::::::::::..: NP_005 MGSGASAEDKELAKRSKELEKKLQEDADKEAKTVKLLLLGAGESGKSTIVKQMKIIHQDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 YSEQECMEFKAVIYSNTLQSILAIVKAMTTLGIDYVNPRSAEDQRQLYAMANTLEDGGMT :: .::.::::.::.:.:::::::..:::::::::..: :.: ::: .:...:.: : NP_005 YSPEECLEFKAIIYGNVLQSILAIIRAMTTLGIDYAEPSCADDGRQLNNLADSIEEGTMP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 PQLAEVIKRLWRDPGIQACFERASEYQLNDSAAYYLNDLDRITASGYVPNEQDVLHSRVK :.:.:::.:::.: :.:::::::.::::::::.::::.:.::: :.:.:::::.:::: NP_005 PELVEVIRRLWKDGGVQACFERAAEYQLNDSASYYLNQLERITDPEYLPSEQDVLRSRVK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TTGIIETQFSFKDLHFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEEV :::::::.:: :::.::::::::::::::::::::::::::::::::::::::::::.:: NP_005 TTGIIETKFSVKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDDEV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 NRMHESLHLFNSICNHKYFSTTSIVLFLNKKDIFQEKVTKVHLSICFPEYTGPNTFEDAG :::::::::::::::::.:..:::::::::::.:.::. ::::::::::: : :...::: NP_005 NRMHESLHLFNSICNHKFFAATSIVLFLNKKDLFEEKIKKVHLSICFPEYDGNNSYDDAG 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 NYIKNQFLDLNLKKEDKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF ::::.::::::..:. :::::::::::::::::::::::::::::::::::::: NP_005 NYIKSQFLDLNMRKDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF 310 320 330 340 350 >>XP_011514426 (OMIM: 139395) PREDICTED: guanine nucleot (297 aa) initn: 1899 init1: 1899 opt: 1899 Z-score: 2247.4 bits: 424.1 E(85289): 1.9e-118 Smith-Waterman score: 1899; 100.0% identity (100.0% similar) in 291 aa overlap (1-291:1-291) 10 20 30 40 50 60 pF1KE3 MGSGISSESKESAKRSKELEKKLQEDAERDARTVKLLLLGAGESGKSTIVKQMKIIHKNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGSGISSESKESAKRSKELEKKLQEDAERDARTVKLLLLGAGESGKSTIVKQMKIIHKNG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 YSEQECMEFKAVIYSNTLQSILAIVKAMTTLGIDYVNPRSAEDQRQLYAMANTLEDGGMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YSEQECMEFKAVIYSNTLQSILAIVKAMTTLGIDYVNPRSAEDQRQLYAMANTLEDGGMT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 PQLAEVIKRLWRDPGIQACFERASEYQLNDSAAYYLNDLDRITASGYVPNEQDVLHSRVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQLAEVIKRLWRDPGIQACFERASEYQLNDSAAYYLNDLDRITASGYVPNEQDVLHSRVK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TTGIIETQFSFKDLHFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTGIIETQFSFKDLHFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEEV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 NRMHESLHLFNSICNHKYFSTTSIVLFLNKKDIFQEKVTKVHLSICFPEYTGPNTFEDAG ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NRMHESLHLFNSICNHKYFSTTSIVLFLNKKDIFQEKVTKVHLSICFPEYTDWHGTL 250 260 270 280 290 310 320 330 340 350 pF1KE3 NYIKNQFLDLNLKKEDKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF >>NP_000163 (OMIM: 139330,610444,616389) guanine nucleot (350 aa) initn: 1844 init1: 1844 opt: 1860 Z-score: 2200.4 bits: 415.6 E(85289): 8e-116 Smith-Waterman score: 1860; 78.2% identity (92.7% similar) in 354 aa overlap (1-354:1-350) 10 20 30 40 50 60 pF1KE3 MGSGISSESKESAKRSKELEKKLQEDAERDARTVKLLLLGAGESGKSTIVKQMKIIHKNG ::.: :.: :.: .::::::.::::.::::::::::::::::::::::::::::..: NP_000 MGAGASAEEKHS----RELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDG 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 YSEQECMEFKAVIYSNTLQSILAIVKAMTTLGIDYVNPRSAEDQRQLYAMANTLEDGGMT :: .::.:: :.::.::::::::::.:::::.:.: . .: :.:. ::.:.:.: : NP_000 YSLEECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMP 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 PQLAEVIKRLWRDPGIQACFERASEYQLNDSAAYYLNDLDRITASGYVPNEQDVLHSRVK .....:.:::.: ::::::::::::::::::.:::.::.:... ::::.:::::.:::: NP_000 KEMSDIIQRLWKDSGIQACFERASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 TTGIIETQFSFKDLHFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEEV ::::::::::::::.:::::::::::::::::::::::::::: :::::::::::::.:: NP_000 TTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEV 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE3 NRMHESLHLFNSICNHKYFSTTSIVLFLNKKDIFQEKVTKVHLSICFPEYTGPNTFEDAG ::::::::::::::::.::.::::::::::::.: ::. :.:::::::.: ::::.:::: NP_000 NRMHESLHLFNSICNHRYFATTSIVLFLNKKDVFFEKIKKAHLSICFPDYDGPNTYEDAG 240 250 260 270 280 290 310 320 330 340 350 pF1KE3 NYIKNQFLDLNLKKEDKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF :::: :::.::.... :::::::::::::::::::::::::::::::::::::: NP_000 NYIKVQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF 300 310 320 330 340 350 >>NP_653082 (OMIM: 139330,610444,616389) guanine nucleot (350 aa) initn: 1844 init1: 1844 opt: 1860 Z-score: 2200.4 bits: 415.6 E(85289): 8e-116 Smith-Waterman score: 1860; 78.2% identity (92.7% similar) in 354 aa overlap (1-354:1-350) 10 20 30 40 50 60 pF1KE3 MGSGISSESKESAKRSKELEKKLQEDAERDARTVKLLLLGAGESGKSTIVKQMKIIHKNG ::.: :.: :.: .::::::.::::.::::::::::::::::::::::::::::..: NP_653 MGAGASAEEKHS----RELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDG 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 YSEQECMEFKAVIYSNTLQSILAIVKAMTTLGIDYVNPRSAEDQRQLYAMANTLEDGGMT :: .::.:: :.::.::::::::::.:::::.:.: . .: :.:. ::.:.:.: : NP_653 YSLEECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMP 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 PQLAEVIKRLWRDPGIQACFERASEYQLNDSAAYYLNDLDRITASGYVPNEQDVLHSRVK .....:.:::.: ::::::::::::::::::.:::.::.:... ::::.:::::.:::: NP_653 KEMSDIIQRLWKDSGIQACFERASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 TTGIIETQFSFKDLHFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEEV ::::::::::::::.:::::::::::::::::::::::::::: :::::::::::::.:: NP_653 TTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEV 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE3 NRMHESLHLFNSICNHKYFSTTSIVLFLNKKDIFQEKVTKVHLSICFPEYTGPNTFEDAG ::::::::::::::::.::.::::::::::::.: ::. :.:::::::.: ::::.:::: NP_653 NRMHESLHLFNSICNHRYFATTSIVLFLNKKDVFFEKIKKAHLSICFPDYDGPNTYEDAG 240 250 260 270 280 290 310 320 330 340 350 pF1KE3 NYIKNQFLDLNLKKEDKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF :::: :::.::.... :::::::::::::::::::::::::::::::::::::: NP_653 NYIKVQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF 300 310 320 330 340 350 >>NP_002061 (OMIM: 139360,192605) guanine nucleotide-bin (355 aa) initn: 1222 init1: 1222 opt: 1697 Z-score: 2007.9 bits: 380.1 E(85289): 4.2e-105 Smith-Waterman score: 1697; 68.7% identity (90.7% similar) in 355 aa overlap (1-354:1-355) 10 20 30 40 50 60 pF1KE3 MGSGISSESKESAKRSKELEKKLQEDAERDARTVKLLLLGAGESGKSTIVKQMKIIHKNG :: .:.:.: .:.::: ..:.:.::.:. :: ::::::::::::::::::::::::..: NP_002 MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 YSEQECMEFKAVIYSNTLQSILAIVKAMTTLGIDYVNPRSAEDQRQLYAMANTLEDGGMT :::.:: ...::.::::.:::.:::::: .: ::...: :.: :::.:.. : :. :. NP_002 YSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPSRADDARQLFALSCTAEEQGVL 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 PQ-LAEVIKRLWRDPGIQACFERASEYQLNDSAAYYLNDLDRITASGYVPNEQDVLHSRV :. :. ::.::: : :.:::: :. :::::::::::::::.::. : :.:..::::..:: NP_002 PDDLSGVIRRLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRV 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 KTTGIIETQFSFKDLHFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEE :::::.::.:.::::::.:::::::::::::::::::::: ::::.::::::.::.:::: NP_002 KTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEE 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 VNRMHESLHLFNSICNHKYFSTTSIVLFLNKKDIFQEKVTKVHLSICFPEYTGPNTFEDA .::::::..::.::::.:.:. :::.:::::::.:.::.:. :.:::::::: : ...: NP_002 MNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITHSPLTICFPEYTGANKYDEA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 GNYIKNQFLDLNLKKEDKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF ..::...: ::: .:. ::::.:.::::::.::.::::::::.:::.:::::::: NP_002 ASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF 310 320 330 340 350 >>NP_002060 (OMIM: 139310) guanine nucleotide-binding pr (354 aa) initn: 1685 init1: 1685 opt: 1685 Z-score: 1993.8 bits: 377.4 E(85289): 2.6e-104 Smith-Waterman score: 1685; 68.4% identity (89.8% similar) in 354 aa overlap (1-354:1-354) 10 20 30 40 50 60 pF1KE3 MGSGISSESKESAKRSKELEKKLQEDAERDARTVKLLLLGAGESGKSTIVKQMKIIHKNG :: .:.:.: ...::: ....:.::.:. :: ::::::::::::::::::::::::. : NP_002 MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 YSEQECMEFKAVIYSNTLQSILAIVKAMTTLGIDYVNPRSAEDQRQLYAMANTLEDGGMT :::.:: ..:::.::::.:::.::..:: : ::. . :.: :::...:.. :.: :: NP_002 YSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 PQLAEVIKRLWRDPGIQACFERASEYQLNDSAAYYLNDLDRITASGYVPNEQDVLHSRVK .:: ::::::.: :.::::.:. ::::::::::::::::::. .:.:..::::..::: NP_002 AELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TTGIIETQFSFKDLHFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEEV ::::.::.:.::::::.:::::::::::::::::::::: ::::.::: ::.::.::::. NP_002 TTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 NRMHESLHLFNSICNHKYFSTTSIVLFLNKKDIFQEKVTKVHLSICFPEYTGPNTFEDAG ::::::..::.::::.:.:. :::.:::::::.:.::. : :.::.:::.: ::.:.:. NP_002 NRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAA 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 NYIKNQFLDLNLKKEDKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF ::. :: ::: .:. ::::.:.::::::.::.::::::::.:::.:::::::: NP_002 AYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF 310 320 330 340 350 >>NP_006487 (OMIM: 139370,602483) guanine nucleotide-bin (354 aa) initn: 1678 init1: 1678 opt: 1678 Z-score: 1985.5 bits: 375.9 E(85289): 7.4e-104 Smith-Waterman score: 1678; 67.5% identity (90.4% similar) in 354 aa overlap (1-354:1-354) 10 20 30 40 50 60 pF1KE3 MGSGISSESKESAKRSKELEKKLQEDAERDARTVKLLLLGAGESGKSTIVKQMKIIHKNG :: .:.:.: ...::: ....:.::.:. :. ::::::::::::::::::::::::..: NP_006 MGCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGESGKSTIVKQMKIIHEDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 YSEQECMEFKAVIYSNTLQSILAIVKAMTTLGIDYVNPRSAEDQRQLYAMANTLEDGGMT :::.:: ..:.:.::::.:::.::..:: : ::. . :.: :::...:.. :.: :: NP_006 YSEDECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGEAARADDARQLFVLAGSAEEGVMT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 PQLAEVIKRLWRDPGIQACFERASEYQLNDSAAYYLNDLDRITASGYVPNEQDVLHSRVK :.:: :::::::: :.:::: :. ::::::::.:::::::::. :.:.:..::::..::: NP_006 PELAGVIKRLWRDGGVQACFSRSREYQLNDSASYYLNDLDRISQSNYIPTQQDVLRTRVK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TTGIIETQFSFKDLHFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEEV ::::.::.:.::::.:.:::::::::::::::::::::: ::::.::: ::.::.::::. NP_006 TTGIVETHFTFKDLYFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 NRMHESLHLFNSICNHKYFSTTSIVLFLNKKDIFQEKVTKVHLSICFPEYTGPNTFEDAG ::::::..::.::::.:.:. :::.:::::::.:.::. . :.::.::::: ::.:.:. NP_006 NRMHESMKLFDSICNNKWFTETSIILFLNKKDLFEEKIKRSPLTICYPEYTGSNTYEEAA 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 NYIKNQFLDLNLKKEDKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF ::. :: ::: .:. ::::.:.::::::.::.::::::::.:::.:::.:::. NP_006 AYIQCQFEDLNRRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKECGLY 310 320 330 340 350 >>NP_001159897 (OMIM: 139360,192605) guanine nucleotide- (318 aa) initn: 1222 init1: 1222 opt: 1562 Z-score: 1849.2 bits: 350.5 E(85289): 2.9e-96 Smith-Waterman score: 1562; 70.3% identity (91.5% similar) in 316 aa overlap (40-354:3-318) 10 20 30 40 50 60 pF1KE3 KESAKRSKELEKKLQEDAERDARTVKLLLLGAGESGKSTIVKQMKIIHKNGYSEQECMEF ::::::::::::::::::..::::.:: .. NP_001 MRGAGESGKSTIVKQMKIIHEDGYSEEECRQY 10 20 30 70 80 90 100 110 120 pF1KE3 KAVIYSNTLQSILAIVKAMTTLGIDYVNPRSAEDQRQLYAMANTLEDGGMTPQ-LAEVIK .::.::::.:::.:::::: .: ::...: :.: :::.:.. : :. :. :. :. ::. NP_001 RAVVYSNTIQSIMAIVKAMGNLQIDFADPSRADDARQLFALSCTAEEQGVLPDDLSGVIR 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE3 RLWRDPGIQACFERASEYQLNDSAAYYLNDLDRITASGYVPNEQDVLHSRVKTTGIIETQ ::: : :.:::: :. :::::::::::::::.::. : :.:..::::..:::::::.::. NP_001 RLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGIVETH 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE3 FSFKDLHFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEEVNRMHESLH :.::::::.:::::::::::::::::::::: ::::.::::::.::.::::.::::::.. NP_001 FTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMK 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE3 LFNSICNHKYFSTTSIVLFLNKKDIFQEKVTKVHLSICFPEYTGPNTFEDAGNYIKNQFL ::.::::.:.:. :::.:::::::.:.::.:. :.:::::::: : ...:..::...: NP_001 LFDSICNNKWFTDTSIILFLNKKDLFEEKITHSPLTICFPEYTGANKYDEAASYIQSKFE 220 230 240 250 260 270 310 320 330 340 350 pF1KE3 DLNLKKEDKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF ::: .:. ::::.:.::::::.::.::::::::.:::.:::::::: NP_001 DLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF 280 290 300 310 354 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 19:57:39 2016 done: Mon Nov 7 19:57:40 2016 Total Scan time: 5.180 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]