FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3268, 666 aa 1>>>pF1KE3268 666 - 666 aa - 666 aa Library: /omim/omim.rfq.tfa 64092750 residues in 91774 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.6175+/-0.000465; mu= -9.7957+/- 0.029 mean_var=374.7257+/-75.553, 0's: 0 Z-trim(120.7): 119 B-trim: 0 in 0/52 Lambda= 0.066255 statistics sampled from 37449 (37575) to 37449 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.708), E-opt: 0.2 (0.409), width: 16 Scan time: 5.840 The best scores are: opt bits E(91774) NP_620147 (OMIM: 610507) RNA polymerase-associated ( 666) 4454 440.3 1.1e-122 NP_001310832 (OMIM: 610507) RNA polymerase-associa ( 688) 4243 420.2 1.4e-116 NP_001310833 (OMIM: 610507) RNA polymerase-associa ( 654) 4232 419.1 2.7e-116 XP_016877400 (OMIM: 610507) RNA polymerase-associa ( 642) 4226 418.5 4e-116 NP_001273359 (OMIM: 610507) RNA polymerase-associa ( 606) 2605 263.6 1.7e-69 NP_055023 (OMIM: 125420,125485,125490,125500,60559 (1301) 430 55.9 1.2e-06 XP_011529368 (OMIM: 300369) acidic repeat-containi ( 673) 294 42.7 0.0057 XP_011529369 (OMIM: 300369) acidic repeat-containi ( 673) 294 42.7 0.0057 XP_016885454 (OMIM: 300369) acidic repeat-containi ( 691) 294 42.7 0.0059 XP_006724779 (OMIM: 300369) acidic repeat-containi ( 691) 294 42.7 0.0059 XP_011529366 (OMIM: 300369) acidic repeat-containi ( 691) 294 42.7 0.0059 NP_443189 (OMIM: 300369) acidic repeat-containing ( 691) 294 42.7 0.0059 XP_011529365 (OMIM: 300369) acidic repeat-containi ( 700) 294 42.7 0.0059 >>NP_620147 (OMIM: 610507) RNA polymerase-associated pro (666 aa) initn: 4454 init1: 4454 opt: 4454 Z-score: 2323.9 bits: 440.3 E(91774): 1.1e-122 Smith-Waterman score: 4454; 100.0% identity (100.0% similar) in 666 aa overlap (1-666:1-666) 10 20 30 40 50 60 pF1KE3 MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 LFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 HRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 HRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 DDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 DDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 EKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 EKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 DTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 DTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 EIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 EIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 RWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 RWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 GQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 GQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 ERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 ERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIRE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 ERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 ERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDE 610 620 630 640 650 660 pF1KE3 EEEDDD :::::: NP_620 EEEDDD >>NP_001310832 (OMIM: 610507) RNA polymerase-associated (688 aa) initn: 4232 init1: 4232 opt: 4243 Z-score: 2214.7 bits: 420.2 E(91774): 1.4e-116 Smith-Waterman score: 4243; 99.4% identity (99.5% similar) in 641 aa overlap (1-641:1-638) 10 20 30 40 50 60 pF1KE3 MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 HRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 DDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 EKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 DTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 EIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 RWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 GQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 ERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIRE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 ERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDE ::::::::::::::::::::::::::::::::: ::::. NP_001 ERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEE---SGKRERPKLKETWRQWKGEVSRPT 610 620 630 640 650 pF1KE3 EEEDDD NP_001 LSFLRQNRKVNLPEREKQKMMIKQIKSIRSM 660 670 680 >>NP_001310833 (OMIM: 610507) RNA polymerase-associated (654 aa) initn: 4226 init1: 4226 opt: 4232 Z-score: 2209.3 bits: 419.1 E(91774): 2.7e-116 Smith-Waterman score: 4232; 98.8% identity (99.4% similar) in 641 aa overlap (1-641:1-641) 10 20 30 40 50 60 pF1KE3 MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 HRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 DDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 EKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 DTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 EIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 RWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 GQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 ERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIRE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 ERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDE :::::::::::::::::::::::::::::::: . : ... NP_001 ERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEVNLPEREKQKMMIKQIKSIRSM 610 620 630 640 650 pF1KE3 EEEDDD >>XP_016877400 (OMIM: 610507) RNA polymerase-associated (642 aa) initn: 4226 init1: 4226 opt: 4226 Z-score: 2206.3 bits: 418.5 E(91774): 4e-116 Smith-Waterman score: 4226; 100.0% identity (100.0% similar) in 632 aa overlap (1-632:1-632) 10 20 30 40 50 60 pF1KE3 MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 HRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 DDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 EKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 DTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 EIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 RWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 GQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 ERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIRE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 ERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDE :::::::::::::::::::::::::::::::: XP_016 ERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEICKNCICLGR 610 620 630 640 pF1KE3 EEEDDD >>NP_001273359 (OMIM: 610507) RNA polymerase-associated (606 aa) initn: 2605 init1: 2605 opt: 2605 Z-score: 1369.3 bits: 263.6 E(91774): 1.7e-69 Smith-Waterman score: 3913; 91.0% identity (91.0% similar) in 666 aa overlap (1-666:1-606) 10 20 30 40 50 60 pF1KE3 MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 HRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 DDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 EKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 DTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 EIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTI :::::::::::::::::::::::::: NP_001 EIPKVNTDLGNDLYFVKLPNFLSVEP---------------------------------- 370 380 430 440 450 460 470 480 pF1KE3 RWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQ :::::::::::::::::::::::::::::::::: NP_001 --------------------------SMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQ 390 400 410 420 490 500 510 520 530 540 pF1KE3 GQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEE 430 440 450 460 470 480 550 560 570 580 590 600 pF1KE3 ERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIRE 490 500 510 520 530 540 610 620 630 640 650 660 pF1KE3 ERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERARIYSSDSDEGSEEDKAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDE 550 560 570 580 590 600 pF1KE3 EEEDDD :::::: NP_001 EEEDDD >>NP_055023 (OMIM: 125420,125485,125490,125500,605594) d (1301 aa) initn: 958 init1: 346 opt: 430 Z-score: 241.1 bits: 55.9 E(91774): 1.2e-06 Smith-Waterman score: 430; 28.6% identity (66.9% similar) in 329 aa overlap (10-329:690-1008) 10 20 30 pF1KE3 MADMEDLFGSDA-DSEAERKDSDSGSDSDSDQENAASGS ::. :: ..:::...::::. .....: NP_055 SNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSS 660 670 680 690 700 710 40 50 60 70 80 90 pF1KE3 NASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHED :...:.::... .::.. ::. .:: : . : .:.... : :.: :..:. :: : NP_055 NSNSSDSDSSNSSDSSDSSNS----SDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSD 720 730 740 750 760 770 100 110 120 130 140 150 pF1KE3 N-DPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDE . : :. .. . : .:. : .. ::... . ...:... ::. . :.:..::. NP_055 SSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSN--SSDSSNSSDSS 780 790 800 810 820 830 160 170 180 190 200 210 pF1KE3 KIQNSDDE----ERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSD .::.: . ..::: :. . ::.... ...:. . . ::. .. :.: . .:: NP_055 DSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSD 840 850 860 870 880 890 220 230 240 250 260 270 pF1KE3 D-ERPVASDND--DEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHK . . .::.: : ...::. .. . :: . .::.:. .... . :.: ..... NP_055 SSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNS 900 910 920 930 940 950 280 290 300 310 320 330 pF1KE3 SESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDK :.:. .::: . ... .::: .::. .:.: . : ..: :..::. : NP_055 SDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSD----SSDSSNSSDSSDS 960 970 980 990 1000 340 350 360 370 380 390 pF1KE3 PPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFD NP_055 SDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1010 1020 1030 1040 1050 1060 >>XP_011529368 (OMIM: 300369) acidic repeat-containing p (673 aa) initn: 435 init1: 182 opt: 294 Z-score: 174.8 bits: 42.7 E(91774): 0.0057 Smith-Waterman score: 343; 30.3% identity (60.4% similar) in 323 aa overlap (3-303:117-428) 10 20 30 pF1KE3 MADMEDLFGSDADSEAERKDSD-SGSDSDSDQ :.: .. :::: .:: : . .:... XP_011 ESPECCHVKPAIQEPPIVISDDDNDDDNGNDLEVPDDNSDDSEAPDDNSDDSEAPDDNSD 90 100 110 120 130 140 40 50 60 70 80 90 pF1KE3 ENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEAS .. : .:.. ::. .:. :: :... .::: :.... ..::..:. :: .. : XP_011 DSEAPDDNSDDSEAPDDNSDDSDVPDDN---SDDSSDDNSD--DSSDDNSDDSDVPDDKS 150 160 170 180 190 200 100 110 120 130 140 pF1KE3 ERSDHEDN--DPSDV--DQHSGSEAPNDDEDEGHRSDGGSHHSEA--EGSEKAHS-DDEK . :: :. : ::: :. . ::::.:. :... : .: ::: ..:. ... :: . XP_011 DDSDVPDDSSDDSDVPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSS 210 220 230 240 250 260 150 160 170 180 190 pF1KE3 WGREDKSDQSDDEKIQN--SDDEE----RAQGSDEDKLQNSDDDEKMQNTDDEERPQLSD : ..:.::: . .. ::: : ... :: . ...:.: .:.:: : : .. XP_011 DDSEASDDSSDDSEASDDSSDDSEAPDDKSDDSDVPEDKSDDSDVPDDNSDDLEVPVPAE 270 280 290 300 310 320 200 210 220 230 240 250 pF1KE3 DERQQLSEEEKANSDDERPV-ASDNDDEKQNSDDEEQPQLSDEEKMQNSDDE-RPQASDE : : .: . ::.:. : :. .....::: . .:... . :: : :..: XP_011 D----LCNEGQIASDEEELVEAAAAVSQHDSSDDAGEQDLGENLSKPPSDPEANPEVS-- 330 340 350 360 370 260 270 280 290 300 310 pF1KE3 EHRHSDDEE-----EQDHKSESARGSDSEDEVLRM-KRKNAIASDSEADSDTEVPKDNSG :.. .:: ::. : .: . : :. : :: . . .. :. XP_011 ERKLPTEEEPAPVVEQSGKRKSKTKTIVEPPRKRQTKTKNIVEPPRKRQTKTKNIVEPLR 380 390 400 410 420 430 320 330 340 350 360 370 pF1KE3 TMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLG XP_011 KRKAKTKNVSVTPGHKKRGPSKKKPGAAKVEKRKTRTPKCKVPGCFLQDLEKSKKYSGKN 440 450 460 470 480 490 >>XP_011529369 (OMIM: 300369) acidic repeat-containing p (673 aa) initn: 435 init1: 182 opt: 294 Z-score: 174.8 bits: 42.7 E(91774): 0.0057 Smith-Waterman score: 343; 30.3% identity (60.4% similar) in 323 aa overlap (3-303:117-428) 10 20 30 pF1KE3 MADMEDLFGSDADSEAERKDSD-SGSDSDSDQ :.: .. :::: .:: : . .:... XP_011 ESPECCHVKPAIQEPPIVISDDDNDDDNGNDLEVPDDNSDDSEAPDDNSDDSEAPDDNSD 90 100 110 120 130 140 40 50 60 70 80 90 pF1KE3 ENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEAS .. : .:.. ::. .:. :: :... .::: :.... ..::..:. :: .. : XP_011 DSEAPDDNSDDSEAPDDNSDDSDVPDDN---SDDSSDDNSD--DSSDDNSDDSDVPDDKS 150 160 170 180 190 200 100 110 120 130 140 pF1KE3 ERSDHEDN--DPSDV--DQHSGSEAPNDDEDEGHRSDGGSHHSEA--EGSEKAHS-DDEK . :: :. : ::: :. . ::::.:. :... : .: ::: ..:. ... :: . XP_011 DDSDVPDDSSDDSDVPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSS 210 220 230 240 250 260 150 160 170 180 190 pF1KE3 WGREDKSDQSDDEKIQN--SDDEE----RAQGSDEDKLQNSDDDEKMQNTDDEERPQLSD : ..:.::: . .. ::: : ... :: . ...:.: .:.:: : : .. XP_011 DDSEASDDSSDDSEASDDSSDDSEAPDDKSDDSDVPEDKSDDSDVPDDNSDDLEVPVPAE 270 280 290 300 310 320 200 210 220 230 240 250 pF1KE3 DERQQLSEEEKANSDDERPV-ASDNDDEKQNSDDEEQPQLSDEEKMQNSDDE-RPQASDE : : .: . ::.:. : :. .....::: . .:... . :: : :..: XP_011 D----LCNEGQIASDEEELVEAAAAVSQHDSSDDAGEQDLGENLSKPPSDPEANPEVS-- 330 340 350 360 370 260 270 280 290 300 310 pF1KE3 EHRHSDDEE-----EQDHKSESARGSDSEDEVLRM-KRKNAIASDSEADSDTEVPKDNSG :.. .:: ::. : .: . : :. : :: . . .. :. XP_011 ERKLPTEEEPAPVVEQSGKRKSKTKTIVEPPRKRQTKTKNIVEPPRKRQTKTKNIVEPLR 380 390 400 410 420 430 320 330 340 350 360 370 pF1KE3 TMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLG XP_011 KRKAKTKNVSVTPGHKKRGPSKKKPGAAKVEKRKTRTPKCKVPGCFLQDLEKSKKYSGKN 440 450 460 470 480 490 >>XP_016885454 (OMIM: 300369) acidic repeat-containing p (691 aa) initn: 435 init1: 182 opt: 294 Z-score: 174.7 bits: 42.7 E(91774): 0.0059 Smith-Waterman score: 343; 30.3% identity (60.4% similar) in 323 aa overlap (3-303:135-446) 10 20 30 pF1KE3 MADMEDLFGSDADSEAERKDSD-SGSDSDSDQ :.: .. :::: .:: : . .:... XP_016 ESPECCHVKPAIQEPPIVISDDDNDDDNGNDLEVPDDNSDDSEAPDDNSDDSEAPDDNSD 110 120 130 140 150 160 40 50 60 70 80 90 pF1KE3 ENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEAS .. : .:.. ::. .:. :: :... .::: :.... ..::..:. :: .. : XP_016 DSEAPDDNSDDSEAPDDNSDDSDVPDDN---SDDSSDDNSD--DSSDDNSDDSDVPDDKS 170 180 190 200 210 100 110 120 130 140 pF1KE3 ERSDHEDN--DPSDV--DQHSGSEAPNDDEDEGHRSDGGSHHSEA--EGSEKAHS-DDEK . :: :. : ::: :. . ::::.:. :... : .: ::: ..:. ... :: . XP_016 DDSDVPDDSSDDSDVPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSS 220 230 240 250 260 270 150 160 170 180 190 pF1KE3 WGREDKSDQSDDEKIQN--SDDEE----RAQGSDEDKLQNSDDDEKMQNTDDEERPQLSD : ..:.::: . .. ::: : ... :: . ...:.: .:.:: : : .. XP_016 DDSEASDDSSDDSEASDDSSDDSEAPDDKSDDSDVPEDKSDDSDVPDDNSDDLEVPVPAE 280 290 300 310 320 330 200 210 220 230 240 250 pF1KE3 DERQQLSEEEKANSDDERPV-ASDNDDEKQNSDDEEQPQLSDEEKMQNSDDE-RPQASDE : : .: . ::.:. : :. .....::: . .:... . :: : :..: XP_016 D----LCNEGQIASDEEELVEAAAAVSQHDSSDDAGEQDLGENLSKPPSDPEANPEVS-- 340 350 360 370 380 390 260 270 280 290 300 310 pF1KE3 EHRHSDDEE-----EQDHKSESARGSDSEDEVLRM-KRKNAIASDSEADSDTEVPKDNSG :.. .:: ::. : .: . : :. : :: . . .. :. XP_016 ERKLPTEEEPAPVVEQSGKRKSKTKTIVEPPRKRQTKTKNIVEPPRKRQTKTKNIVEPLR 400 410 420 430 440 450 320 330 340 350 360 370 pF1KE3 TMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLG XP_016 KRKAKTKNVSVTPGHKKRGPSKKKPGAAKVEKRKTRTPKCKVPGCFLQDLEKSKKYSGKN 460 470 480 490 500 510 >>XP_006724779 (OMIM: 300369) acidic repeat-containing p (691 aa) initn: 435 init1: 182 opt: 294 Z-score: 174.7 bits: 42.7 E(91774): 0.0059 Smith-Waterman score: 343; 30.3% identity (60.4% similar) in 323 aa overlap (3-303:135-446) 10 20 30 pF1KE3 MADMEDLFGSDADSEAERKDSD-SGSDSDSDQ :.: .. :::: .:: : . .:... XP_006 ESPECCHVKPAIQEPPIVISDDDNDDDNGNDLEVPDDNSDDSEAPDDNSDDSEAPDDNSD 110 120 130 140 150 160 40 50 60 70 80 90 pF1KE3 ENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEAS .. : .:.. ::. .:. :: :... .::: :.... ..::..:. :: .. : XP_006 DSEAPDDNSDDSEAPDDNSDDSDVPDDN---SDDSSDDNSD--DSSDDNSDDSDVPDDKS 170 180 190 200 210 100 110 120 130 140 pF1KE3 ERSDHEDN--DPSDV--DQHSGSEAPNDDEDEGHRSDGGSHHSEA--EGSEKAHS-DDEK . :: :. : ::: :. . ::::.:. :... : .: ::: ..:. ... :: . XP_006 DDSDVPDDSSDDSDVPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSS 220 230 240 250 260 270 150 160 170 180 190 pF1KE3 WGREDKSDQSDDEKIQN--SDDEE----RAQGSDEDKLQNSDDDEKMQNTDDEERPQLSD : ..:.::: . .. ::: : ... :: . ...:.: .:.:: : : .. XP_006 DDSEASDDSSDDSEASDDSSDDSEAPDDKSDDSDVPEDKSDDSDVPDDNSDDLEVPVPAE 280 290 300 310 320 330 200 210 220 230 240 250 pF1KE3 DERQQLSEEEKANSDDERPV-ASDNDDEKQNSDDEEQPQLSDEEKMQNSDDE-RPQASDE : : .: . ::.:. : :. .....::: . .:... . :: : :..: XP_006 D----LCNEGQIASDEEELVEAAAAVSQHDSSDDAGEQDLGENLSKPPSDPEANPEVS-- 340 350 360 370 380 390 260 270 280 290 300 310 pF1KE3 EHRHSDDEE-----EQDHKSESARGSDSEDEVLRM-KRKNAIASDSEADSDTEVPKDNSG :.. .:: ::. : .: . : :. : :: . . .. :. XP_006 ERKLPTEEEPAPVVEQSGKRKSKTKTIVEPPRKRQTKTKNIVEPPRKRQTKTKNIVEPLR 400 410 420 430 440 450 320 330 340 350 360 370 pF1KE3 TMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLG XP_006 KRKAKTKNVSVTPGHKKRGPSKKKPGAAKVEKRKTRTPKCKVPGCFLQDLEKSKKYSGKN 460 470 480 490 500 510 666 residues in 1 query sequences 64092750 residues in 91774 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Jul 16 15:58:10 2019 done: Tue Jul 16 15:58:11 2019 Total Scan time: 5.840 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]