Result of FASTA (omim) for
pF1KE3269
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3269, 670 aa
1>>>pF1KE3269 670 - 670 aa - 670 aa
Library: /omim/omim.rfq.tfa
61265892 residues in 86068 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.9767+/-0.000485; mu= 8.6114+/- 0.030
mean_var=228.1889+/-49.770, 0's: 0 Z-trim(116.4): 191 B-trim: 1834 in 2/51
Lambda= 0.084904
statistics sampled from 27513 (27732) to 27513 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.668), E-opt: 0.2 (0.322), width: 16
Scan time: 11.190
The best scores are: opt bits E(86068)
NP_115647 (OMIM: 606692) E3 ubiquitin-protein liga ( 670) 4569 573.5 8.9e-163
XP_005255684 (OMIM: 606692) PREDICTED: E3 ubiquiti ( 668) 4539 569.8 1.1e-161
XP_011521002 (OMIM: 606692) PREDICTED: E3 ubiquiti ( 641) 4375 549.7 1.2e-155
XP_011530390 (OMIM: 606278) PREDICTED: F-box/WD re ( 540) 487 73.4 2.5e-12
NP_001013433 (OMIM: 606278) F-box/WD repeat-contai ( 589) 487 73.4 2.7e-12
NP_060785 (OMIM: 606278) F-box/WD repeat-containin ( 627) 487 73.5 2.8e-12
XP_011530388 (OMIM: 606278) PREDICTED: F-box/WD re ( 679) 487 73.5 3e-12
XP_011530389 (OMIM: 606278) PREDICTED: F-box/WD re ( 679) 487 73.5 3e-12
NP_361014 (OMIM: 606278) F-box/WD repeat-containin ( 707) 487 73.5 3e-12
XP_011530385 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 487 73.5 3e-12
XP_011530386 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 487 73.5 3e-12
XP_016863851 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 487 73.5 3e-12
XP_011530387 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 487 73.5 3e-12
NP_079510 (OMIM: 609540) WD repeat-containing prot ( 305) 289 48.9 3.4e-05
XP_011520396 (OMIM: 609540) PREDICTED: WD repeat-c ( 305) 289 48.9 3.4e-05
NP_001290176 (OMIM: 609540) WD repeat-containing p ( 305) 289 48.9 3.4e-05
NP_001309196 (OMIM: 607795,615922) U4/U6 small nuc ( 279) 266 46.0 0.00023
NP_001309195 (OMIM: 607795,615922) U4/U6 small nuc ( 279) 266 46.0 0.00023
XP_016861593 (OMIM: 614783,614813) PREDICTED: POC1 ( 321) 265 45.9 0.00027
NP_001155052 (OMIM: 614783,614813) POC1 centriolar ( 359) 265 46.0 0.00029
NP_001155053 (OMIM: 614783,614813) POC1 centriolar ( 369) 265 46.0 0.0003
NP_056241 (OMIM: 614783,614813) POC1 centriolar pr ( 407) 265 46.1 0.00032
NP_004688 (OMIM: 607795,615922) U4/U6 small nuclea ( 522) 266 46.3 0.00035
XP_011531864 (OMIM: 614783,614813) PREDICTED: POC1 ( 300) 252 44.3 0.00079
XP_011531863 (OMIM: 614783,614813) PREDICTED: POC1 ( 326) 252 44.4 0.00083
XP_011531862 (OMIM: 614783,614813) PREDICTED: POC1 ( 374) 252 44.4 0.00091
XP_011523806 (OMIM: 602464) PREDICTED: TNF recepto ( 477) 253 44.7 0.00099
NP_942593 (OMIM: 610767,611081) autophagy-related ( 444) 249 44.1 0.0013
XP_005246143 (OMIM: 610767,611081) PREDICTED: auto ( 463) 249 44.2 0.0014
XP_005246141 (OMIM: 610767,611081) PREDICTED: auto ( 480) 249 44.2 0.0014
NP_001177196 (OMIM: 610767,611081) autophagy-relat ( 491) 249 44.2 0.0014
NP_001177195 (OMIM: 610767,611081) autophagy-relat ( 523) 249 44.2 0.0015
XP_006712671 (OMIM: 610767,611081) PREDICTED: auto ( 540) 249 44.2 0.0015
NP_060444 (OMIM: 610767,611081) autophagy-related ( 588) 249 44.3 0.0016
NP_110430 (OMIM: 610767,611081) autophagy-related ( 607) 249 44.3 0.0016
XP_005246139 (OMIM: 610767,611081) PREDICTED: auto ( 624) 249 44.3 0.0017
XP_011508261 (OMIM: 602356) PREDICTED: TNF recepto ( 568) 244 43.6 0.0024
NP_001306136 (OMIM: 602356) TNF receptor-associate ( 568) 244 43.6 0.0024
XP_011508262 (OMIM: 602356) PREDICTED: TNF recepto ( 568) 244 43.6 0.0024
XP_011508259 (OMIM: 602356) PREDICTED: TNF recepto ( 631) 242 43.4 0.003
NP_001188493 (OMIM: 605961) pleiotropic regulator ( 505) 235 42.5 0.0047
NP_002660 (OMIM: 605961) pleiotropic regulator 1 i ( 514) 235 42.5 0.0048
XP_011538622 (OMIM: 603482) PREDICTED: F-box/WD re ( 537) 228 41.7 0.0089
XP_016872363 (OMIM: 603482) PREDICTED: F-box/WD re ( 543) 228 41.7 0.009
NP_438172 (OMIM: 609012) WD repeat-containing prot ( 334) 224 40.9 0.0091
XP_005272220 (OMIM: 609012) PREDICTED: WD repeat-c ( 334) 224 40.9 0.0091
NP_060058 (OMIM: 609012) WD repeat-containing prot ( 334) 224 40.9 0.0091
NP_003930 (OMIM: 603482) F-box/WD repeat-containin ( 569) 228 41.7 0.0093
NP_001243785 (OMIM: 603482) F-box/WD repeat-contai ( 579) 228 41.7 0.0094
XP_016872360 (OMIM: 603482) PREDICTED: F-box/WD re ( 587) 228 41.7 0.0095
>>NP_115647 (OMIM: 606692) E3 ubiquitin-protein ligase T (670 aa)
initn: 4569 init1: 4569 opt: 4569 Z-score: 3043.4 bits: 573.5 E(86068): 8.9e-163
Smith-Waterman score: 4569; 100.0% identity (100.0% similar) in 670 aa overlap (1-670:1-670)
10 20 30 40 50 60
pF1KE3 MSSGKSARYNRFSGGPSNLPTPDVTTGTRMETTFGPAFSAVTTITKADGTSTYKQHCRTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 MSSGKSARYNRFSGGPSNLPTPDVTTGTRMETTFGPAFSAVTTITKADGTSTYKQHCRTP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 SSSSTLAYSPRDEEDSMPPISTPRRSDSAISVRSLHSESSMSLRSTFSLPEEEEEPEPLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 SSSSTLAYSPRDEEDSMPPISTPRRSDSAISVRSLHSESSMSLRSTFSLPEEEEEPEPLV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 FAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEKCPVDNVKLTVVVNNIAVAEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 FAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEKCPVDNVKLTVVVNNIAVAEQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 IGELFIHCRHGCRVAGSGKPPIFEVDPRGCPFTIKLSARKDHEGSCDYRPVRCPNNPSCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 IGELFIHCRHGCRVAGSGKPPIFEVDPRGCPFTIKLSARKDHEGSCDYRPVRCPNNPSCP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 PLLRMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 PLLRMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 MHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 MHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 LNDELSHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 LNDELSHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 KVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 KVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 PVCTLVSSHNVLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 PVCTLVSSHNVLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 IKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 IKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 TVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 TVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGA
610 620 630 640 650 660
670
pF1KE3 VDSTVKVWTC
::::::::::
NP_115 VDSTVKVWTC
670
>>XP_005255684 (OMIM: 606692) PREDICTED: E3 ubiquitin-pr (668 aa)
initn: 4539 init1: 2718 opt: 4539 Z-score: 3023.6 bits: 569.8 E(86068): 1.1e-161
Smith-Waterman score: 4539; 99.7% identity (99.7% similar) in 670 aa overlap (1-670:1-668)
10 20 30 40 50 60
pF1KE3 MSSGKSARYNRFSGGPSNLPTPDVTTGTRMETTFGPAFSAVTTITKADGTSTYKQHCRTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSSGKSARYNRFSGGPSNLPTPDVTTGTRMETTFGPAFSAVTTITKADGTSTYKQHCRTP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 SSSSTLAYSPRDEEDSMPPISTPRRSDSAISVRSLHSESSMSLRSTFSLPEEEEEPEPLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSSSTLAYSPRDEEDSMPPISTPRRSDSAISVRSLHSESSMSLRSTFSLPEEEEEPEPLV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 FAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEKCPVDNVKLTVVVNNIAVAEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEKCPVDNVKLTVVVNNIAVAEQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 IGELFIHCRHGCRVAGSGKPPIFEVDPRGCPFTIKLSARKDHEGSCDYRPVRCPNNPSCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IGELFIHCRHGCRVAGSGKPPIFEVDPRGCPFTIKLSARKDHEGSCDYRPVRCPNNPSCP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 PLLRMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHE
::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::
XP_005 PLLRMNLEAHLKECEHIKCPHSK--CTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHE
250 260 270 280 290
310 320 330 340 350 360
pF1KE3 MHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASM
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE3 LNDELSHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNDELSHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTI
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE3 KVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDN
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE3 PVCTLVSSHNVLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PVCTLVSSHNVLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQT
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE3 IKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVG
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE3 TVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGA
600 610 620 630 640 650
670
pF1KE3 VDSTVKVWTC
::::::::::
XP_005 VDSTVKVWTC
660
>>XP_011521002 (OMIM: 606692) PREDICTED: E3 ubiquitin-pr (641 aa)
initn: 4375 init1: 4375 opt: 4375 Z-score: 2915.2 bits: 549.7 E(86068): 1.2e-155
Smith-Waterman score: 4375; 100.0% identity (100.0% similar) in 641 aa overlap (30-670:1-641)
10 20 30 40 50 60
pF1KE3 MSSGKSARYNRFSGGPSNLPTPDVTTGTRMETTFGPAFSAVTTITKADGTSTYKQHCRTP
:::::::::::::::::::::::::::::::
XP_011 METTFGPAFSAVTTITKADGTSTYKQHCRTP
10 20 30
70 80 90 100 110 120
pF1KE3 SSSSTLAYSPRDEEDSMPPISTPRRSDSAISVRSLHSESSMSLRSTFSLPEEEEEPEPLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSSTLAYSPRDEEDSMPPISTPRRSDSAISVRSLHSESSMSLRSTFSLPEEEEEPEPLV
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE3 FAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEKCPVDNVKLTVVVNNIAVAEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEKCPVDNVKLTVVVNNIAVAEQ
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE3 IGELFIHCRHGCRVAGSGKPPIFEVDPRGCPFTIKLSARKDHEGSCDYRPVRCPNNPSCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IGELFIHCRHGCRVAGSGKPPIFEVDPRGCPFTIKLSARKDHEGSCDYRPVRCPNNPSCP
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE3 PLLRMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLLRMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHE
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE3 MHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASM
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE3 LNDELSHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNDELSHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTI
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE3 KVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDN
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE3 PVCTLVSSHNVLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVCTLVSSHNVLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQT
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE3 IKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVG
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE3 TVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGA
580 590 600 610 620 630
670
pF1KE3 VDSTVKVWTC
::::::::::
XP_011 VDSTVKVWTC
640
>>XP_011530390 (OMIM: 606278) PREDICTED: F-box/WD repeat (540 aa)
initn: 358 init1: 252 opt: 487 Z-score: 342.3 bits: 73.4 E(86068): 2.5e-12
Smith-Waterman score: 491; 28.7% identity (58.0% similar) in 414 aa overlap (279-668:90-482)
250 260 270 280 290 300
pF1KE3 AHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHEMHVALAQK
...:. .:...: . .:.. ..: :
XP_011 SVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPK
60 70 80 90 100 110
310 320 330 340 350 360
pF1KE3 DQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASMLN-DELSH
. . .. :.: : : :. . .. :.:: . .:. . . :: :
XP_011 ELAL-YVLSFL----EPKDLLQAAQTCRY------WRILAEDNLLWREKCKEEGIDEPLH
120 130 140 150 160
370 380 390 400 410
pF1KE3 INAR--LNMGILGS-----YDPQQI---------FKCKGTFVGHQGPVWCLCVYSMGDLL
:. : .. :.. : : :. .: .. ::. : :. :. .
XP_011 IKRRKVIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHV-ITCLQFCGNRI
170 180 190 200 210 220
420 430 440 450 460 470
pF1KE3 FSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQK
:::.:.:.::: . .: :: .:: :: : : . .. . :::.: :. ::. .. .
XP_011 VSGSDDNTLKVW-SAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGEC
230 240 250 260 270 280
480 490 500 510 520
pF1KE3 VNTIRAHDNPV-CTLVSSHNVLFSGSLKA-IKVWDI-VGTELKLKKELTGLNHWVRALVA
..:. .: . : : . . :. ::: : ..:::: .: :.. : : :: .
XP_011 IHTLYGHTSTVRCMHLHEKRVV-SGSRDATLRVWDIETGQCLHV---LMGHVAAVRCVQY
290 300 310 320 330 340
530 540 550 560 570 580
pF1KE3 AQSYLYSGSYQ-TIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIE
. ::.:. .:.:: .: :.:.:: . :::. . :.: :. .. :.:::.:
XP_011 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVE
350 360 370 380 390 400
590 600 610 620 630 640
pF1KE3 SKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLL---RHQG
. . ..::::: . . .. . :. : :.. : ....:.. . : ::: .::.
XP_011 TGNCIHTLTGHQSLTSGMEL---KDNILV-SGNADSTVKIWDIKTGQCLQTLQGPNKHQS
410 420 430 440 450
650 660 670
pF1KE3 SVTALAVSRGRLFSGAVDSTVKVWTC
.:: : ... ..... :.:::.:
XP_011 AVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCA
460 470 480 490 500 510
>>NP_001013433 (OMIM: 606278) F-box/WD repeat-containing (589 aa)
initn: 358 init1: 252 opt: 487 Z-score: 341.8 bits: 73.4 E(86068): 2.7e-12
Smith-Waterman score: 491; 28.7% identity (58.0% similar) in 414 aa overlap (279-668:139-531)
250 260 270 280 290 300
pF1KE3 AHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHEMHVALAQK
...:. .:...: . .:.. ..: :
NP_001 SVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPK
110 120 130 140 150 160
310 320 330 340 350 360
pF1KE3 DQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASMLN-DELSH
. . .. :.: : : :. . .. :.:: . .:. . . :: :
NP_001 ELAL-YVLSFL----EPKDLLQAAQTCRY------WRILAEDNLLWREKCKEEGIDEPLH
170 180 190 200 210
370 380 390 400 410
pF1KE3 INAR--LNMGILGS-----YDPQQI---------FKCKGTFVGHQGPVWCLCVYSMGDLL
:. : .. :.. : : :. .: .. ::. : :. :. .
NP_001 IKRRKVIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHV-ITCLQFCGNRI
220 230 240 250 260 270
420 430 440 450 460 470
pF1KE3 FSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQK
:::.:.:.::: . .: :: .:: :: : : . .. . :::.: :. ::. .. .
NP_001 VSGSDDNTLKVW-SAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGEC
280 290 300 310 320 330
480 490 500 510 520
pF1KE3 VNTIRAHDNPV-CTLVSSHNVLFSGSLKA-IKVWDI-VGTELKLKKELTGLNHWVRALVA
..:. .: . : : . . :. ::: : ..:::: .: :.. : : :: .
NP_001 IHTLYGHTSTVRCMHLHEKRVV-SGSRDATLRVWDIETGQCLHV---LMGHVAAVRCVQY
340 350 360 370 380 390
530 540 550 560 570 580
pF1KE3 AQSYLYSGSYQ-TIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIE
. ::.:. .:.:: .: :.:.:: . :::. . :.: :. .. :.:::.:
NP_001 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVE
400 410 420 430 440 450
590 600 610 620 630 640
pF1KE3 SKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLL---RHQG
. . ..::::: . . .. . :. : :.. : ....:.. . : ::: .::.
NP_001 TGNCIHTLTGHQSLTSGMEL---KDNILV-SGNADSTVKIWDIKTGQCLQTLQGPNKHQS
460 470 480 490 500
650 660 670
pF1KE3 SVTALAVSRGRLFSGAVDSTVKVWTC
.:: : ... ..... :.:::.:
NP_001 AVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCA
510 520 530 540 550 560
>>NP_060785 (OMIM: 606278) F-box/WD repeat-containing pr (627 aa)
initn: 358 init1: 252 opt: 487 Z-score: 341.5 bits: 73.5 E(86068): 2.8e-12
Smith-Waterman score: 491; 28.7% identity (58.0% similar) in 414 aa overlap (279-668:177-569)
250 260 270 280 290 300
pF1KE3 AHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHEMHVALAQK
...:. .:...: . .:.. ..: :
NP_060 SVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPK
150 160 170 180 190 200
310 320 330 340 350 360
pF1KE3 DQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASMLN-DELSH
. . .. :.: : : :. . .. :.:: . .:. . . :: :
NP_060 ELAL-YVLSFL----EPKDLLQAAQTCRY------WRILAEDNLLWREKCKEEGIDEPLH
210 220 230 240 250
370 380 390 400 410
pF1KE3 INAR--LNMGILGS-----YDPQQI---------FKCKGTFVGHQGPVWCLCVYSMGDLL
:. : .. :.. : : :. .: .. ::. : :. :. .
NP_060 IKRRKVIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHV-ITCLQFCGNRI
260 270 280 290 300 310
420 430 440 450 460 470
pF1KE3 FSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQK
:::.:.:.::: . .: :: .:: :: : : . .. . :::.: :. ::. .. .
NP_060 VSGSDDNTLKVW-SAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGEC
320 330 340 350 360 370
480 490 500 510 520
pF1KE3 VNTIRAHDNPV-CTLVSSHNVLFSGSLKA-IKVWDI-VGTELKLKKELTGLNHWVRALVA
..:. .: . : : . . :. ::: : ..:::: .: :.. : : :: .
NP_060 IHTLYGHTSTVRCMHLHEKRVV-SGSRDATLRVWDIETGQCLHV---LMGHVAAVRCVQY
380 390 400 410 420
530 540 550 560 570 580
pF1KE3 AQSYLYSGSYQ-TIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIE
. ::.:. .:.:: .: :.:.:: . :::. . :.: :. .. :.:::.:
NP_060 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVE
430 440 450 460 470 480
590 600 610 620 630 640
pF1KE3 SKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLL---RHQG
. . ..::::: . . .. . :. : :.. : ....:.. . : ::: .::.
NP_060 TGNCIHTLTGHQSLTSGMEL---KDNILV-SGNADSTVKIWDIKTGQCLQTLQGPNKHQS
490 500 510 520 530 540
650 660 670
pF1KE3 SVTALAVSRGRLFSGAVDSTVKVWTC
.:: : ... ..... :.:::.:
NP_060 AVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCA
550 560 570 580 590 600
>>XP_011530388 (OMIM: 606278) PREDICTED: F-box/WD repeat (679 aa)
initn: 358 init1: 252 opt: 487 Z-score: 341.1 bits: 73.5 E(86068): 3e-12
Smith-Waterman score: 491; 28.7% identity (58.0% similar) in 414 aa overlap (279-668:229-621)
250 260 270 280 290 300
pF1KE3 AHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHEMHVALAQK
...:. .:...: . .:.. ..: :
XP_011 SVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPK
200 210 220 230 240 250
310 320 330 340 350 360
pF1KE3 DQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASMLN-DELSH
. . .. :.: : : :. . .. :.:: . .:. . . :: :
XP_011 ELAL-YVLSFL----EPKDLLQAAQTCRY------WRILAEDNLLWREKCKEEGIDEPLH
260 270 280 290 300
370 380 390 400 410
pF1KE3 INAR--LNMGILGS-----YDPQQI---------FKCKGTFVGHQGPVWCLCVYSMGDLL
:. : .. :.. : : :. .: .. ::. : :. :. .
XP_011 IKRRKVIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHV-ITCLQFCGNRI
310 320 330 340 350 360
420 430 440 450 460 470
pF1KE3 FSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQK
:::.:.:.::: . .: :: .:: :: : : . .. . :::.: :. ::. .. .
XP_011 VSGSDDNTLKVW-SAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGEC
370 380 390 400 410 420
480 490 500 510 520
pF1KE3 VNTIRAHDNPV-CTLVSSHNVLFSGSLKA-IKVWDI-VGTELKLKKELTGLNHWVRALVA
..:. .: . : : . . :. ::: : ..:::: .: :.. : : :: .
XP_011 IHTLYGHTSTVRCMHLHEKRVV-SGSRDATLRVWDIETGQCLHV---LMGHVAAVRCVQY
430 440 450 460 470 480
530 540 550 560 570 580
pF1KE3 AQSYLYSGSYQ-TIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIE
. ::.:. .:.:: .: :.:.:: . :::. . :.: :. .. :.:::.:
XP_011 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVE
490 500 510 520 530 540
590 600 610 620 630 640
pF1KE3 SKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLL---RHQG
. . ..::::: . . .. . :. : :.. : ....:.. . : ::: .::.
XP_011 TGNCIHTLTGHQSLTSGMEL---KDNILV-SGNADSTVKIWDIKTGQCLQTLQGPNKHQS
550 560 570 580 590
650 660 670
pF1KE3 SVTALAVSRGRLFSGAVDSTVKVWTC
.:: : ... ..... :.:::.:
XP_011 AVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCA
600 610 620 630 640 650
>>XP_011530389 (OMIM: 606278) PREDICTED: F-box/WD repeat (679 aa)
initn: 358 init1: 252 opt: 487 Z-score: 341.1 bits: 73.5 E(86068): 3e-12
Smith-Waterman score: 491; 28.7% identity (58.0% similar) in 414 aa overlap (279-668:229-621)
250 260 270 280 290 300
pF1KE3 AHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHEMHVALAQK
...:. .:...: . .:.. ..: :
XP_011 SVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPK
200 210 220 230 240 250
310 320 330 340 350 360
pF1KE3 DQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASMLN-DELSH
. . .. :.: : : :. . .. :.:: . .:. . . :: :
XP_011 ELAL-YVLSFL----EPKDLLQAAQTCRY------WRILAEDNLLWREKCKEEGIDEPLH
260 270 280 290 300
370 380 390 400 410
pF1KE3 INAR--LNMGILGS-----YDPQQI---------FKCKGTFVGHQGPVWCLCVYSMGDLL
:. : .. :.. : : :. .: .. ::. : :. :. .
XP_011 IKRRKVIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHV-ITCLQFCGNRI
310 320 330 340 350 360
420 430 440 450 460 470
pF1KE3 FSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQK
:::.:.:.::: . .: :: .:: :: : : . .. . :::.: :. ::. .. .
XP_011 VSGSDDNTLKVW-SAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGEC
370 380 390 400 410 420
480 490 500 510 520
pF1KE3 VNTIRAHDNPV-CTLVSSHNVLFSGSLKA-IKVWDI-VGTELKLKKELTGLNHWVRALVA
..:. .: . : : . . :. ::: : ..:::: .: :.. : : :: .
XP_011 IHTLYGHTSTVRCMHLHEKRVV-SGSRDATLRVWDIETGQCLHV---LMGHVAAVRCVQY
430 440 450 460 470 480
530 540 550 560 570 580
pF1KE3 AQSYLYSGSYQ-TIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIE
. ::.:. .:.:: .: :.:.:: . :::. . :.: :. .. :.:::.:
XP_011 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVE
490 500 510 520 530 540
590 600 610 620 630 640
pF1KE3 SKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLL---RHQG
. . ..::::: . . .. . :. : :.. : ....:.. . : ::: .::.
XP_011 TGNCIHTLTGHQSLTSGMEL---KDNILV-SGNADSTVKIWDIKTGQCLQTLQGPNKHQS
550 560 570 580 590
650 660 670
pF1KE3 SVTALAVSRGRLFSGAVDSTVKVWTC
.:: : ... ..... :.:::.:
XP_011 AVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCA
600 610 620 630 640 650
>>NP_361014 (OMIM: 606278) F-box/WD repeat-containing pr (707 aa)
initn: 358 init1: 252 opt: 487 Z-score: 340.9 bits: 73.5 E(86068): 3e-12
Smith-Waterman score: 491; 28.7% identity (58.0% similar) in 414 aa overlap (279-668:257-649)
250 260 270 280 290 300
pF1KE3 AHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHEMHVALAQK
...:. .:...: . .:.. ..: :
NP_361 SVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPK
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE3 DQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASMLN-DELSH
. . .. :.: : : :. . .. :.:: . .:. . . :: :
NP_361 ELAL-YVLSFL----EPKDLLQAAQTCRY------WRILAEDNLLWREKCKEEGIDEPLH
290 300 310 320 330
370 380 390 400 410
pF1KE3 INAR--LNMGILGS-----YDPQQI---------FKCKGTFVGHQGPVWCLCVYSMGDLL
:. : .. :.. : : :. .: .. ::. : :. :. .
NP_361 IKRRKVIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHV-ITCLQFCGNRI
340 350 360 370 380 390
420 430 440 450 460 470
pF1KE3 FSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQK
:::.:.:.::: . .: :: .:: :: : : . .. . :::.: :. ::. .. .
NP_361 VSGSDDNTLKVW-SAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGEC
400 410 420 430 440 450
480 490 500 510 520
pF1KE3 VNTIRAHDNPV-CTLVSSHNVLFSGSLKA-IKVWDI-VGTELKLKKELTGLNHWVRALVA
..:. .: . : : . . :. ::: : ..:::: .: :.. : : :: .
NP_361 IHTLYGHTSTVRCMHLHEKRVV-SGSRDATLRVWDIETGQCLHV---LMGHVAAVRCVQY
460 470 480 490 500
530 540 550 560 570 580
pF1KE3 AQSYLYSGSYQ-TIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIE
. ::.:. .:.:: .: :.:.:: . :::. . :.: :. .. :.:::.:
NP_361 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVE
510 520 530 540 550 560
590 600 610 620 630 640
pF1KE3 SKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLL---RHQG
. . ..::::: . . .. . :. : :.. : ....:.. . : ::: .::.
NP_361 TGNCIHTLTGHQSLTSGMEL---KDNILV-SGNADSTVKIWDIKTGQCLQTLQGPNKHQS
570 580 590 600 610 620
650 660 670
pF1KE3 SVTALAVSRGRLFSGAVDSTVKVWTC
.:: : ... ..... :.:::.:
NP_361 AVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCA
630 640 650 660 670 680
>>XP_011530385 (OMIM: 606278) PREDICTED: F-box/WD repeat (707 aa)
initn: 358 init1: 252 opt: 487 Z-score: 340.9 bits: 73.5 E(86068): 3e-12
Smith-Waterman score: 491; 28.7% identity (58.0% similar) in 414 aa overlap (279-668:257-649)
250 260 270 280 290 300
pF1KE3 AHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHEMHVALAQK
...:. .:...: . .:.. ..: :
XP_011 SVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPK
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE3 DQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASMLN-DELSH
. . .. :.: : : :. . .. :.:: . .:. . . :: :
XP_011 ELAL-YVLSFL----EPKDLLQAAQTCRY------WRILAEDNLLWREKCKEEGIDEPLH
290 300 310 320 330
370 380 390 400 410
pF1KE3 INAR--LNMGILGS-----YDPQQI---------FKCKGTFVGHQGPVWCLCVYSMGDLL
:. : .. :.. : : :. .: .. ::. : :. :. .
XP_011 IKRRKVIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHV-ITCLQFCGNRI
340 350 360 370 380 390
420 430 440 450 460 470
pF1KE3 FSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQK
:::.:.:.::: . .: :: .:: :: : : . .. . :::.: :. ::. .. .
XP_011 VSGSDDNTLKVW-SAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGEC
400 410 420 430 440 450
480 490 500 510 520
pF1KE3 VNTIRAHDNPV-CTLVSSHNVLFSGSLKA-IKVWDI-VGTELKLKKELTGLNHWVRALVA
..:. .: . : : . . :. ::: : ..:::: .: :.. : : :: .
XP_011 IHTLYGHTSTVRCMHLHEKRVV-SGSRDATLRVWDIETGQCLHV---LMGHVAAVRCVQY
460 470 480 490 500
530 540 550 560 570 580
pF1KE3 AQSYLYSGSYQ-TIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIE
. ::.:. .:.:: .: :.:.:: . :::. . :.: :. .. :.:::.:
XP_011 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVE
510 520 530 540 550 560
590 600 610 620 630 640
pF1KE3 SKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLL---RHQG
. . ..::::: . . .. . :. : :.. : ....:.. . : ::: .::.
XP_011 TGNCIHTLTGHQSLTSGMEL---KDNILV-SGNADSTVKIWDIKTGQCLQTLQGPNKHQS
570 580 590 600 610 620
650 660 670
pF1KE3 SVTALAVSRGRLFSGAVDSTVKVWTC
.:: : ... ..... :.:::.:
XP_011 AVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCA
630 640 650 660 670 680
670 residues in 1 query sequences
61265892 residues in 86068 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Feb 10 15:02:36 2017 done: Fri Feb 10 15:02:38 2017
Total Scan time: 11.190 Total Display time: 0.150
Function used was FASTA [36.3.4 Apr, 2011]