FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3319, 889 aa 1>>>pF1KE3319 889 - 889 aa - 889 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.6500+/-0.000467; mu= -6.6782+/- 0.029 mean_var=577.9337+/-128.246, 0's: 0 Z-trim(123.2): 1468 B-trim: 981 in 1/53 Lambda= 0.053350 statistics sampled from 40393 (42635) to 40393 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.784), E-opt: 0.2 (0.5), width: 16 Scan time: 14.740 The best scores are: opt bits E(85289) NP_037487 (OMIM: 610714) serine/threonine-protein ( 889) 6044 481.0 1e-134 XP_005252003 (OMIM: 610714) PREDICTED: serine/thre ( 886) 5997 477.4 1.3e-133 XP_006717143 (OMIM: 610714) PREDICTED: serine/thre ( 896) 5992 477.0 1.7e-133 NP_001304855 (OMIM: 610714) serine/threonine-prote ( 833) 5460 436.1 3.4e-121 XP_016870138 (OMIM: 610714) PREDICTED: serine/thre ( 840) 5408 432.1 5.5e-120 XP_016870139 (OMIM: 610714) PREDICTED: serine/thre ( 763) 5186 414.9 7.2e-115 NP_002732 (OMIM: 601032) serine/threonine-protein ( 942) 2192 184.6 1.9e-45 NP_998725 (OMIM: 601032) serine/threonine-protein ( 948) 2192 184.6 1.9e-45 XP_011526430 (OMIM: 601032) PREDICTED: serine/thre ( 954) 2192 184.6 1.9e-45 XP_016857272 (OMIM: 602549) PREDICTED: serine/thre ( 920) 2184 184.0 2.9e-45 XP_016857271 (OMIM: 602549) PREDICTED: serine/thre ( 922) 2158 182.0 1.2e-44 NP_001307636 (OMIM: 602549) serine/threonine-prote ( 936) 1668 144.3 2.7e-33 XP_011540074 (OMIM: 602549) PREDICTED: serine/thre ( 658) 1569 136.4 4.2e-31 NP_001307637 (OMIM: 602549) serine/threonine-prote ( 827) 1569 136.6 4.8e-31 NP_001307638 (OMIM: 602549) serine/threonine-prote ( 968) 1569 136.7 5.3e-31 NP_006247 (OMIM: 602549) serine/threonine-protein ( 984) 1569 136.7 5.4e-31 NP_002729 (OMIM: 176970) protein kinase C beta typ ( 673) 1041 95.8 7.3e-19 XP_016880329 (OMIM: 176960) PREDICTED: protein kin ( 586) 1032 95.1 1.1e-18 XP_016880327 (OMIM: 176960) PREDICTED: protein kin ( 586) 1032 95.1 1.1e-18 XP_016880328 (OMIM: 176960) PREDICTED: protein kin ( 586) 1032 95.1 1.1e-18 NP_002728 (OMIM: 176960) protein kinase C alpha ty ( 672) 1033 95.2 1.1e-18 XP_016880326 (OMIM: 176960) PREDICTED: protein kin ( 621) 1032 95.1 1.1e-18 NP_001229956 (OMIM: 125853,164731,240900) RAC-beta ( 419) 997 92.2 5.7e-18 NP_001229957 (OMIM: 125853,164731,240900) RAC-beta ( 419) 997 92.2 5.7e-18 XP_011524917 (OMIM: 125853,164731,240900) PREDICTE ( 481) 997 92.3 6.2e-18 XP_016881959 (OMIM: 125853,164731,240900) PREDICTE ( 481) 997 92.3 6.2e-18 XP_011524916 (OMIM: 125853,164731,240900) PREDICTE ( 481) 997 92.3 6.2e-18 XP_011524918 (OMIM: 125853,164731,240900) PREDICTE ( 481) 997 92.3 6.2e-18 XP_011524920 (OMIM: 125853,164731,240900) PREDICTE ( 481) 997 92.3 6.2e-18 XP_011524921 (OMIM: 125853,164731,240900) PREDICTE ( 481) 997 92.3 6.2e-18 XP_011524922 (OMIM: 125853,164731,240900) PREDICTE ( 481) 997 92.3 6.2e-18 NP_001617 (OMIM: 125853,164731,240900) RAC-beta se ( 481) 997 92.3 6.2e-18 NP_001303256 (OMIM: 176977,615559) protein kinase ( 676) 1000 92.7 6.5e-18 NP_997704 (OMIM: 176977,615559) protein kinase C d ( 676) 1000 92.7 6.5e-18 XP_016862344 (OMIM: 176977,615559) PREDICTED: prot ( 676) 1000 92.7 6.5e-18 XP_016862345 (OMIM: 176977,615559) PREDICTED: prot ( 676) 1000 92.7 6.5e-18 XP_006713322 (OMIM: 176977,615559) PREDICTED: prot ( 676) 1000 92.7 6.5e-18 NP_006245 (OMIM: 176977,615559) protein kinase C d ( 676) 1000 92.7 6.5e-18 XP_006713320 (OMIM: 176977,615559) PREDICTED: prot ( 692) 1000 92.7 6.6e-18 XP_016855474 (OMIM: 611223,615937) PREDICTED: RAC- ( 418) 990 91.6 8.2e-18 NP_859029 (OMIM: 611223,615937) RAC-gamma serine/t ( 465) 990 91.7 8.8e-18 NP_001193658 (OMIM: 611223,615937) RAC-gamma serin ( 465) 990 91.7 8.8e-18 XP_005273052 (OMIM: 611223,615937) PREDICTED: RAC- ( 479) 990 91.7 9e-18 XP_005273051 (OMIM: 611223,615937) PREDICTED: RAC- ( 479) 990 91.7 9e-18 NP_005456 (OMIM: 611223,615937) RAC-gamma serine/t ( 479) 990 91.7 9e-18 NP_002730 (OMIM: 176980,605361) protein kinase C g ( 697) 994 92.2 9.1e-18 NP_001303258 (OMIM: 176980,605361) protein kinase ( 710) 994 92.2 9.2e-18 XP_016871900 (OMIM: 600448) PREDICTED: protein kin ( 581) 990 91.8 1e-17 NP_001269574 (OMIM: 600448) protein kinase C theta ( 581) 990 91.8 1e-17 NP_001310195 (OMIM: 600448) protein kinase C theta ( 581) 990 91.8 1e-17 >>NP_037487 (OMIM: 610714) serine/threonine-protein kina (889 aa) initn: 6044 init1: 6044 opt: 6044 Z-score: 2539.4 bits: 481.0 E(85289): 1e-134 Smith-Waterman score: 6044; 100.0% identity (100.0% similar) in 889 aa overlap (1-889:1-889) 10 20 30 40 50 60 pF1KE3 MEEGAPRQPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 MEEGAPRQPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 NRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQLHVELKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 NRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQLHVELKV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 KQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGPELLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 KQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGPELLA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 EELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 EELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 EQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLTAVPGRSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 EQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLTAVPGRSP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 AAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 AAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 PLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVTFCDPVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 PLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVTFCDPVI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 ERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISPPKGCPRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 ERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISPPKGCPRT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 PTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRPHMEPRTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 PTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRPHMEPRTR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 RGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 RGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 IESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 IESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 ARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 ARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFC 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 GTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 GTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 FLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 FLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLC 790 800 810 820 830 840 850 860 870 880 pF1KE3 GPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLEP ::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 GPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLEP 850 860 870 880 >>XP_005252003 (OMIM: 610714) PREDICTED: serine/threonin (886 aa) initn: 5997 init1: 5997 opt: 5997 Z-score: 2519.9 bits: 477.4 E(85289): 1.3e-133 Smith-Waterman score: 5997; 99.9% identity (100.0% similar) in 883 aa overlap (7-889:4-886) 10 20 30 40 50 60 pF1KE3 MEEGAPRQPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSS :.:::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEHREPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSS 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 NRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQLHVELKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQLHVELKV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 KQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGPELLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGPELLA 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 EELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE3 EQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLTAVPGRSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLTAVPGRSP 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE3 AAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVI 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE3 PLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVTFCDPVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVTFCDPVI 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE3 ERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISPPKGCPRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISPPKGCPRT 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE3 PTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRPHMEPRTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRPHMEPRTR 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE3 RGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDE 540 550 560 570 580 590 610 620 630 640 650 660 pF1KE3 IESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQ 600 610 620 630 640 650 670 680 690 700 710 720 pF1KE3 ARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFC 660 670 680 690 700 710 730 740 750 760 770 780 pF1KE3 GTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPG 720 730 740 750 760 770 790 800 810 820 830 840 pF1KE3 FLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLC 780 790 800 810 820 830 850 860 870 880 pF1KE3 GPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLEP ::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLEP 840 850 860 870 880 >>XP_006717143 (OMIM: 610714) PREDICTED: serine/threonin (896 aa) initn: 5988 init1: 5988 opt: 5992 Z-score: 2517.7 bits: 477.0 E(85289): 1.7e-133 Smith-Waterman score: 5992; 99.4% identity (99.7% similar) in 887 aa overlap (3-889:10-896) 10 20 30 40 50 pF1KE3 MEEGAPRQPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHV .:. ::::::::::::::::::::::::::::::::::::::::::::: XP_006 MRGERPPPPQGGNLWPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 QQLLRSSNRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QQLLRSSNRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 LHVELKVKQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LHVELKVKQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 PGPELLAEELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PGPELLAEELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLR 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 LALEQLLEQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LALEQLLEQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLT 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 AVPGRSPAAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AVPGRSPAAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE3 WDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQV 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE3 TFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE3 PKGCPRTPTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PKGCPRTPTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRP 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE3 HMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQ 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE3 EVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHE 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE3 DVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFG 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE3 DRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVN 730 740 750 760 770 780 780 790 800 810 820 830 pF1KE3 MDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQP 790 800 810 820 830 840 840 850 860 870 880 pF1KE3 PFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLEP 850 860 870 880 890 >>NP_001304855 (OMIM: 610714) serine/threonine-protein k (833 aa) initn: 5603 init1: 5460 opt: 5460 Z-score: 2296.8 bits: 436.1 E(85289): 3.4e-121 Smith-Waterman score: 5467; 96.4% identity (96.8% similar) in 845 aa overlap (1-845:1-833) 10 20 30 40 50 60 pF1KE3 MEEGAPRQPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEEGAPRQPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 NRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQLHVELKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQLHVELKV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 KQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGPELLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGPELLA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 EELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 EQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLTAVPGRSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLTAVPGRSP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 AAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 PLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVTFCDPVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVTFCDPVI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 ERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISPPKGCPRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISPPKGCPRT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 PTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRPHMEPRTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRPHMEPRTR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 RGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 IESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 ARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFC 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 GTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 FLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLC :::::::::::::::::::::::: .: : : . : : . : : NP_001 FLSVQGLEFIQKLLQKCPEKRLGADHQLASPA------RPHHPAPLRAYPVWP------C 790 800 810 820 850 860 870 880 pF1KE3 GPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLEP ::: : NP_001 GPALL 830 >>XP_016870138 (OMIM: 610714) PREDICTED: serine/threonin (840 aa) initn: 5547 init1: 5404 opt: 5408 Z-score: 2275.1 bits: 432.1 E(85289): 5.5e-120 Smith-Waterman score: 5415; 95.8% identity (96.4% similar) in 843 aa overlap (3-845:10-840) 10 20 30 40 50 pF1KE3 MEEGAPRQPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHV .:. ::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRGERPPPPQGGNLWPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 QQLLRSSNRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQLLRSSNRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 LHVELKVKQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHVELKVKQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 PGPELLAEELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGPELLAEELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLR 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 LALEQLLEQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LALEQLLEQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLT 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 AVPGRSPAAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVPGRSPAAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE3 WDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQV 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE3 TFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE3 PKGCPRTPTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PKGCPRTPTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRP 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE3 HMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQ 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE3 EVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHE 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE3 DVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFG 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE3 DRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVN 730 740 750 760 770 780 780 790 800 810 820 830 pF1KE3 MDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQP ::::::::::::::::::::::::::::::: .: : : . : : . : XP_016 MDAPYPGFLSVQGLEFIQKLLQKCPEKRLGADHQLASPA------RPHHPAPLRAYPVWP 790 800 810 820 830 840 850 860 870 880 pF1KE3 PFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLEP :::: : XP_016 ------CGPALL 840 >>XP_016870139 (OMIM: 610714) PREDICTED: serine/threonin (763 aa) initn: 5186 init1: 5186 opt: 5186 Z-score: 2183.2 bits: 414.9 E(85289): 7.2e-115 Smith-Waterman score: 5186; 100.0% identity (100.0% similar) in 763 aa overlap (127-889:1-763) 100 110 120 130 140 150 pF1KE3 PWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKV :::::::::::::::::::::::::::::: XP_016 MTHTCASGTPKERKLLAAAQQMLRDSQLKV 10 20 30 160 170 180 190 200 210 pF1KE3 ALLRMKISSLEASGSPEPGPELLAEELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALLRMKISSLEASGSPEPGPELLAEELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALA 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE3 EAQAQLQESSQKLDLLRLALEQLLEQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EAQAQLQESSQKLDLLRLALEQLLEQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTA 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE3 LTGTLQVRLLGCEQLLTAVPGRSPAAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LTGTLQVRLLGCEQLLTAVPGRSPAAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKV 160 170 180 190 200 210 340 350 360 370 380 390 pF1KE3 DNRVVGQTGWGQVAEQSWDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DNRVVGQTGWGQVAEQSWDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNAC 220 230 240 250 260 270 400 410 420 430 440 450 pF1KE3 HQLSLSLVPQGLLFAQVTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HQLSLSLVPQGLLFAQVTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGR 280 290 300 310 320 330 460 470 480 490 500 510 pF1KE3 LVMNLLPPCSSPSTISPPKGCPRTPTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVMNLLPPCSSPSTISPPKGCPRTPTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRL 340 350 360 370 380 390 520 530 540 550 560 570 pF1KE3 YLPQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLPQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLV 400 410 420 430 440 450 580 590 600 610 620 630 pF1KE3 QFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHAC 460 470 480 490 500 510 640 650 660 670 680 690 pF1KE3 FVTEFVPGGDLMMQIHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FVTEFVPGGDLMMQIHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQG 520 530 540 550 560 570 700 710 720 730 740 750 pF1KE3 FLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGE 580 590 600 610 620 630 760 770 780 790 800 810 pF1KE3 CPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQP 640 650 660 670 680 690 820 830 840 850 860 870 pF1KE3 FFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAF 700 710 720 730 740 750 880 pF1KE3 RDFDFVSERFLEP ::::::::::::: XP_016 RDFDFVSERFLEP 760 >>NP_002732 (OMIM: 601032) serine/threonine-protein kina (942 aa) initn: 2916 init1: 1581 opt: 2192 Z-score: 936.8 bits: 184.6 E(85289): 1.9e-45 Smith-Waterman score: 2958; 53.1% identity (74.1% similar) in 928 aa overlap (9-883:29-939) 10 20 30 40 pF1KE3 MEEGAPRQPGPSQWPPEDEKEVIRRAIQKELKIKEGVENL :: .: : :.: .:: :.::::.:::.::: NP_002 MASDAVQSEPRSWSLLEQLGLAGADLAAPGVQQQL-ELERERLRREIRKELKLKEGAENL 10 20 30 40 50 50 60 70 80 90 pF1KE3 RRVATDR-RHLGHVQQLLRSSNRRLEQLHGELRELHARILLPGPGP---GPAEPVASGPR ::..:: : :: :. :::.:.:::. :: .:.::::...:: :. :: : :.:: NP_002 RRATTDLGRSLGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAATHDGPQSPGAGGPT 60 70 80 90 100 110 100 110 120 130 140 150 pF1KE3 PWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKV : .: .. .:..:: .::::::::::: .: ..:. :.:::: .:::::.::. :. NP_002 CSATNLS--RVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKI 120 130 140 150 160 170 160 170 180 190 200 pF1KE3 ALLRMKIS-SLEAS------------GSPEPGP-ELLAEELQHRLHVEAAVAEGAKNVVK ..::.. .:.:. :::. : :: :::.:...:: :::::::::.. NP_002 DIIRMQLRRALQAGQLENQAAPDDTQGSPDLGAVELRIEELRHHFRVEHAVAEGAKNVLR 180 190 200 210 220 230 210 220 230 240 250 260 pF1KE3 LLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLLEQLPPAHPLRSRVTRELRAAVP :::. .. ::::..::: .: ::.::: ::: :::. : .:: :: ..:. :: ::. NP_002 LLSAAKAPDRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHP-KGRLLREELAAAS 240 250 260 270 280 290 270 280 290 300 pF1KE3 GY--------PQPS---GTPVKPTALTGTLQVRLLGCEQLLTAVP-GRSPAAA------- . : :. .: ::. :::::.::..::..: ..: . .:. . NP_002 SAAFSTRLAGPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPWNPTPSMGGPGTPDS 300 310 320 330 340 350 310 320 330 340 350 pF1KE3 ---LASSPSEGWLRTKAKHQRGRGEL------ASEVLAVLKVDNRVVGQTGWGQVAEQSW . : :..: : ... ::. : .::: .:::.:: :::::.: . ..: NP_002 RPPFLSRPARG-LYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQTSWKPCGPNAW 360 370 380 390 400 410 360 370 380 390 400 410 pF1KE3 DQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVT ::.:.. ::::::::..: ::: : ::.. ::.::::::: :...:.. ::: : :.:: NP_002 DQSFTLELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAEVT 420 430 440 450 460 470 420 430 440 450 460 470 pF1KE3 FCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISP- : .::::: :::.::..::::..:. : :: :::. .:.: ::. :.: .. .:.:: NP_002 FRNPVIERIPRLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPNATGTGTFSPG 480 490 500 510 520 530 480 490 500 510 520 pF1KE3 --PKGCPRTPTTLR-EASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLP-QEPTSEETPR : . :: . : . .: :. :.:. :: .: : : :: :. : : NP_002 ASPGSEARTTGDISVEKLNLGTDSDSSPQKS----SRDPPSSPSSLSSPIQESTAPELPS 540 550 560 570 580 590 530 540 550 560 570 580 pF1KE3 TKRPHMEPRTRRGPSPP-ASPTRKPP-RLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAI .:.. :.: :: :: : :.::. :::::::::::::: .:. .:. .:: NP_002 --------ETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAI 600 610 620 630 640 590 600 610 620 630 640 pF1KE3 KALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDL ::::: ....:::.:::.:::::: :: .:::::..:..:::: :.::: :. :::: NP_002 KALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDL 650 660 670 680 690 700 650 660 670 680 690 700 pF1KE3 MMQIHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCK :..:: ::: ::.: :: ::::::::::::.::.::::::::::::..:..::::::::: NP_002 MLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCK 710 720 730 740 750 760 710 720 730 740 750 760 pF1KE3 EGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEV ::.:.::::::::::::::::::::. .::::::::::::::::::::: ::::: :::: NP_002 EGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEV 770 780 790 800 810 820 770 780 790 800 810 820 pF1KE3 FDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALL :: ::: .. :: :::.... ....::.. ::.:::..:.:::..: :::::: .:.::: NP_002 FDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALL 830 840 850 860 870 880 830 840 850 860 870 880 pF1KE3 ARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFL :: . ::::::: : .:. :. :::: :.:.:: ::: .:::: :::::. NP_002 ARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGGC 890 900 910 920 930 940 pF1KE3 EP >>NP_998725 (OMIM: 601032) serine/threonine-protein kina (948 aa) initn: 2916 init1: 1581 opt: 2192 Z-score: 936.8 bits: 184.6 E(85289): 1.9e-45 Smith-Waterman score: 2958; 53.1% identity (74.1% similar) in 928 aa overlap (9-883:35-945) 10 20 30 pF1KE3 MEEGAPRQPGPSQWPPEDEKEVIRRAIQKELKIKEGVE :: .: : :.: .:: :.::::.:::.: NP_998 NNPSEQELESEPRSWSLLEQLGLAGADLAAPGVQQQL-ELERERLRREIRKELKLKEGAE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE3 NLRRVATDR-RHLGHVQQLLRSSNRRLEQLHGELRELHARILLPGPGP---GPAEPVASG ::::..:: : :: :. :::.:.:::. :: .:.::::...:: :. :: : :.: NP_998 NLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAATHDGPQSPGAGG 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE3 PRPWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCASGTPKERKLLAAAQQMLRDSQL : : .: .. .:..:: .::::::::::: .: ..:. :.:::: .:::::.::. NP_998 PTCSATNLS--RVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKT 130 140 150 160 170 180 160 170 180 190 200 pF1KE3 KVALLRMKIS-SLEAS------------GSPEPGP-ELLAEELQHRLHVEAAVAEGAKNV :. ..::.. .:.:. :::. : :: :::.:...:: ::::::::: NP_998 KIDIIRMQLRRALQAGQLENQAAPDDTQGSPDLGAVELRIEELRHHFRVEHAVAEGAKNV 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE3 VKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLLEQLPPAHPLRSRVTRELRAA ..:::. .. ::::..::: .: ::.::: ::: :::. : .:: :: ..:. :: :: NP_998 LRLLSAAKAPDRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHP-KGRLLREELAA 250 260 270 280 290 300 270 280 290 300 pF1KE3 VPGY--------PQPS---GTPVKPTALTGTLQVRLLGCEQLLTAVP-GRSPAAA----- . . : :. .: ::. :::::.::..::..: ..: . .:. . NP_998 ASSAAFSTRLAGPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPWNPTPSMGGPGTP 310 320 330 340 350 360 310 320 330 340 350 pF1KE3 -----LASSPSEGWLRTKAKHQRGRGEL------ASEVLAVLKVDNRVVGQTGWGQVAEQ . : :..: : ... ::. : .::: .:::.:: :::::.: . . NP_998 DSRPPFLSRPARG-LYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQTSWKPCGPN 370 380 390 400 410 360 370 380 390 400 410 pF1KE3 SWDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQ .:::.:.. ::::::::..: ::: : ::.. ::.::::::: :...:.. ::: : :. NP_998 AWDQSFTLELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAE 420 430 440 450 460 470 420 430 440 450 460 470 pF1KE3 VTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTIS ::: .::::: :::.::..::::..:. : :: :::. .:.: ::. :.: .. .:.: NP_998 VTFRNPVIERIPRLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPNATGTGTFS 480 490 500 510 520 530 480 490 500 510 520 pF1KE3 P---PKGCPRTPTTLR-EASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLP-QEPTSEET : : . :: . : . .: :. :.:. :: .: : : :: :. : NP_998 PGASPGSEARTTGDISVEKLNLGTDSDSSPQKS----SRDPPSSPSSLSSPIQESTAPEL 540 550 560 570 580 590 530 540 550 560 570 580 pF1KE3 PRTKRPHMEPRTRRGPSPP-ASPTRKPP-RLQDFRCLAVLGRGHFGKVLLVQFKGTGKYY : .:.. :.: :: :: : :.::. :::::::::::::: .:. .:. . NP_998 PS--------ETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELF 600 610 620 630 640 590 600 610 620 630 640 pF1KE3 AIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGG ::::::: ....:::.:::.:::::: :: .:::::..:..:::: :.::: :. :: NP_998 AIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGG 650 660 670 680 690 700 650 660 670 680 690 700 pF1KE3 DLMMQIHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGL :::..:: ::: ::.: :: ::::::::::::.::.::::::::::::..:..::::::: NP_998 DLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGL 710 720 730 740 750 760 710 720 730 740 750 760 pF1KE3 CKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEE ::::.:.::::::::::::::::::::. .::::::::::::::::::::: ::::: :: NP_998 CKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEE 770 780 790 800 810 820 770 780 790 800 810 820 pF1KE3 EVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQA :::: ::: .. :: :::.... ....::.. ::.:::..:.:::..: :::::: .:.: NP_998 EVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEA 830 840 850 860 870 880 830 840 850 860 870 880 pF1KE3 LLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSER :::: . ::::::: : .:. :. :::: :.:.:: ::: .:::: :::::. NP_998 LLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGG 890 900 910 920 930 940 pF1KE3 FLEP NP_998 C >>XP_011526430 (OMIM: 601032) PREDICTED: serine/threonin (954 aa) initn: 2916 init1: 1581 opt: 2192 Z-score: 936.7 bits: 184.6 E(85289): 1.9e-45 Smith-Waterman score: 2958; 53.1% identity (74.1% similar) in 928 aa overlap (9-883:41-951) 10 20 30 pF1KE3 MEEGAPRQPGPSQWPPEDEKEVIRRAIQKELKIKEGVE :: .: : :.: .:: :.::::.:::.: XP_011 RIWCCRSHKSEPRSWSLLEQLGLAGADLAAPGVQQQL-ELERERLRREIRKELKLKEGAE 20 30 40 50 60 40 50 60 70 80 90 pF1KE3 NLRRVATDR-RHLGHVQQLLRSSNRRLEQLHGELRELHARILLPGPGP---GPAEPVASG ::::..:: : :: :. :::.:.:::. :: .:.::::...:: :. :: : :.: XP_011 NLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAATHDGPQSPGAGG 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE3 PRPWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCASGTPKERKLLAAAQQMLRDSQL : : .: .. .:..:: .::::::::::: .: ..:. :.:::: .:::::.::. XP_011 PTCSATNLS--RVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKT 130 140 150 160 170 180 160 170 180 190 200 pF1KE3 KVALLRMKIS-SLEAS------------GSPEPGP-ELLAEELQHRLHVEAAVAEGAKNV :. ..::.. .:.:. :::. : :: :::.:...:: ::::::::: XP_011 KIDIIRMQLRRALQAGQLENQAAPDDTQGSPDLGAVELRIEELRHHFRVEHAVAEGAKNV 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE3 VKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLLEQLPPAHPLRSRVTRELRAA ..:::. .. ::::..::: .: ::.::: ::: :::. : .:: :: ..:. :: :: XP_011 LRLLSAAKAPDRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHP-KGRLLREELAA 250 260 270 280 290 300 270 280 290 300 pF1KE3 VPGY--------PQPS---GTPVKPTALTGTLQVRLLGCEQLLTAVP-GRSPAAA----- . . : :. .: ::. :::::.::..::..: ..: . .:. . XP_011 ASSAAFSTRLAGPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPWNPTPSMGGPGTP 310 320 330 340 350 360 310 320 330 340 350 pF1KE3 -----LASSPSEGWLRTKAKHQRGRGEL------ASEVLAVLKVDNRVVGQTGWGQVAEQ . : :..: : ... ::. : .::: .:::.:: :::::.: . . XP_011 DSRPPFLSRPARG-LYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQTSWKPCGPN 370 380 390 400 410 420 360 370 380 390 400 410 pF1KE3 SWDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQ .:::.:.. ::::::::..: ::: : ::.. ::.::::::: :...:.. ::: : :. XP_011 AWDQSFTLELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAE 430 440 450 460 470 480 420 430 440 450 460 470 pF1KE3 VTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTIS ::: .::::: :::.::..::::..:. : :: :::. .:.: ::. :.: .. .:.: XP_011 VTFRNPVIERIPRLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPNATGTGTFS 490 500 510 520 530 540 480 490 500 510 520 pF1KE3 P---PKGCPRTPTTLR-EASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLP-QEPTSEET : : . :: . : . .: :. :.:. :: .: : : :: :. : XP_011 PGASPGSEARTTGDISVEKLNLGTDSDSSPQKS----SRDPPSSPSSLSSPIQESTAPEL 550 560 570 580 590 600 530 540 550 560 570 580 pF1KE3 PRTKRPHMEPRTRRGPSPP-ASPTRKPP-RLQDFRCLAVLGRGHFGKVLLVQFKGTGKYY : .:.. :.: :: :: : :.::. :::::::::::::: .:. .:. . XP_011 PS--------ETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELF 610 620 630 640 650 590 600 610 620 630 640 pF1KE3 AIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGG ::::::: ....:::.:::.:::::: :: .:::::..:..:::: :.::: :. :: XP_011 AIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGG 660 670 680 690 700 710 650 660 670 680 690 700 pF1KE3 DLMMQIHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGL :::..:: ::: ::.: :: ::::::::::::.::.::::::::::::..:..::::::: XP_011 DLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGL 720 730 740 750 760 770 710 720 730 740 750 760 pF1KE3 CKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEE ::::.:.::::::::::::::::::::. .::::::::::::::::::::: ::::: :: XP_011 CKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEE 780 790 800 810 820 830 770 780 790 800 810 820 pF1KE3 EVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQA :::: ::: .. :: :::.... ....::.. ::.:::..:.:::..: :::::: .:.: XP_011 EVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEA 840 850 860 870 880 890 830 840 850 860 870 880 pF1KE3 LLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSER :::: . ::::::: : .:. :. :::: :.:.:: ::: .:::: :::::. XP_011 LLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGG 900 910 920 930 940 950 pF1KE3 FLEP XP_011 C >>XP_016857272 (OMIM: 602549) PREDICTED: serine/threonin (920 aa) initn: 2653 init1: 1551 opt: 2184 Z-score: 933.6 bits: 184.0 E(85289): 2.9e-45 Smith-Waterman score: 2648; 47.8% identity (69.9% similar) in 934 aa overlap (13-884:42-918) 10 20 30 40 pF1KE3 MEEGAPRQPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRR : .: :. :.: :.::::::::.::::. XP_016 LTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKELKIKEGAENLRK 20 30 40 50 60 70 50 60 70 80 90 pF1KE3 VATDRRHLGHVQQLLRSSNRRLEQLHGELRELHARILLPGP---GPGPAEPVASGPRPWA :.::.. :..:...:..::..::.:: .:.::.:.:.. : : : . . : XP_016 VTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPRTPDTPNNDPRC 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE3 EQLRARHLEALRRQLHVELKVKQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALL : :.::..:: .::::::::::: . ..:. :.::: ..:::.:.::. :. .. XP_016 STSNNR-LKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLLQDSKTKIEVI 140 150 160 170 180 190 160 170 180 190 200 pF1KE3 RMKISSLEA---------SGSPEPGP-ELLAEELQHRLHVEAAVAEGAKNVVKLLSSRRT ::.: :.: ...: .: :: :::.:....: :::::::::.:::.: .. XP_016 RMQI--LQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKV 200 210 220 230 240 210 220 230 240 250 260 pF1KE3 QDRKALAEAQAQLQESSQKLDLLRLALEQLLEQLPPAHPLRSRVTRE---LRAAVPGY-P :::::.::::...:::::::::. .::: :...: :: .::. : : :: : : XP_016 TDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHP-KSRIIIEELSLVAASPTLSP 250 260 270 280 290 300 270 280 290 300 310 pF1KE3 QPS--------GTPVKPTALTGTLQVRLLGCEQLLTAVPGRSPAAALASSPSEGWLRTKA . : .: ::.::::::.:::.::...: ::::: :...: : :: ... XP_016 RQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVAL-P--GWSPSET 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE3 KHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLERARELEIGVHWRDW . . ..: ::::.:: :::::.: ...::::: :.. :.: XP_016 RSSFMSRTSKNDVCAVLKLDNTVVGQTSWKPISNQSWDQKFTLELDR------------- 370 380 390 400 410 380 390 400 410 420 430 pF1KE3 RQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVTFCDPVIERRPRLQRQERIFSKRR ::: .:::::::.::::..::::.. XP_016 -----------------------------------VTFFNPVIERRPKLQRQKKIFSKQQ 420 430 440 450 460 470 480 490 pF1KE3 GQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISP----PKGCPRTPTTLREASDPATP :. :::: :::...:.::::: .: . .:.:: : : . . . . . ::. XP_016 GKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPVPTTVPVVDVRIPQLAPPASD 440 450 460 470 480 490 500 510 520 530 pF1KE3 SNFLPKKTPLGEEMTPPPKPPR---------------LYLP-QEPTSEETPRTKRPHMEP :. : . : ::: ::: : .: :. . .. : . : XP_016 STV--TKLDFDLEPEPPPAPPRASSLGEIDESSELRVLDIPGQDSETVFDIQNDRNSILP 500 510 520 530 540 550 540 550 560 570 580 pF1KE3 RTRR--GPSPPAS-----------PTRKPPR----LQDFRCLAVLGRGHFGKVLLVQFKG ... :. : : :. : :::::: :::::::::::::...:. XP_016 KSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKN 560 570 580 590 600 610 590 600 610 620 630 640 pF1KE3 TGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTE :....::::::: ....:::..::.:::::.:.:. . ::::..:.:::::. :.::: : XP_016 TNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVME 620 630 640 650 660 670 650 660 670 680 690 700 pF1KE3 FVPGGDLMMQIHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKI .. ::::::.:: ::: ::.: ::.::::::::.:::.::.::::::::::::..::.:: XP_016 YAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKI 680 690 700 710 720 730 710 720 730 740 750 760 pF1KE3 ADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFP :::::::::.:.::::::::::::::::::::. .:::::::::::::.::::::: ::: XP_016 ADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFP 740 750 760 770 780 790 770 780 790 800 810 820 pF1KE3 GDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRT :: :::::: ::: .. :: :::.... ....::.. ::.::::.:.:::..: .:::: XP_016 GDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRL 800 810 820 830 840 850 830 840 850 860 870 880 pF1KE3 TNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFD .:.::. . ..:::.::. : :. :. :::. : :::: .:. ..: ::::: XP_016 IDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDFD 860 870 880 890 900 910 pF1KE3 FVSERFLEP .... XP_016 YIADWC 920 889 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 15:41:39 2016 done: Sun Nov 6 15:41:41 2016 Total Scan time: 14.740 Total Display time: 0.370 Function used was FASTA [36.3.4 Apr, 2011]