FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3330, 943 aa 1>>>pF1KE3330 943 - 943 aa - 943 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 13.8138+/-0.000604; mu= -18.6079+/- 0.037 mean_var=814.5618+/-180.167, 0's: 0 Z-trim(119.0): 709 B-trim: 0 in 0/57 Lambda= 0.044938 statistics sampled from 31894 (32625) to 31894 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.703), E-opt: 0.2 (0.383), width: 16 Scan time: 12.650 The best scores are: opt bits E(85289) NP_004551 (OMIM: 113000,268310,602337) tyrosine-pr ( 943) 6520 439.8 3.2e-122 XP_016870251 (OMIM: 113000,268310,602337) PREDICTE ( 940) 6318 426.7 2.8e-118 XP_005252065 (OMIM: 113000,268310,602337) PREDICTE ( 803) 5567 377.9 1.1e-103 XP_016870252 (OMIM: 113000,268310,602337) PREDICTE ( 803) 5567 377.9 1.1e-103 XP_006717184 (OMIM: 113000,268310,602337) PREDICTE ( 803) 5567 377.9 1.1e-103 XP_005252066 (OMIM: 113000,268310,602337) PREDICTE ( 542) 3682 255.5 5.5e-67 NP_005003 (OMIM: 602336) inactive tyrosine-protein ( 937) 3657 254.1 2.4e-66 XP_016856865 (OMIM: 602336) PREDICTED: inactive ty ( 917) 3642 253.2 4.6e-66 XP_011539828 (OMIM: 602336) PREDICTED: inactive ty ( 874) 3606 250.8 2.2e-65 XP_016856866 (OMIM: 602336) PREDICTED: inactive ty ( 874) 3606 250.8 2.2e-65 NP_001305133 (OMIM: 113000,268310,602337) tyrosine ( 432) 2713 192.5 3.9e-48 NP_001077061 (OMIM: 602336) inactive tyrosine-prot ( 393) 1768 131.2 1e-29 XP_011517010 (OMIM: 208150,601296,616325) PREDICTE ( 457) 876 73.5 2.8e-12 NP_001159753 (OMIM: 208150,601296,616325) muscle, ( 773) 876 73.7 3.9e-12 NP_001159752 (OMIM: 208150,601296,616325) muscle, ( 783) 876 73.7 4e-12 XP_016870223 (OMIM: 208150,601296,616325) PREDICTE ( 791) 876 73.8 4e-12 XP_005252053 (OMIM: 208150,601296,616325) PREDICTE ( 861) 876 73.8 4.2e-12 NP_005583 (OMIM: 208150,601296,616325) muscle, ske ( 869) 876 73.8 4.2e-12 XP_005252052 (OMIM: 208150,601296,616325) PREDICTE ( 871) 876 73.8 4.3e-12 XP_005252051 (OMIM: 208150,601296,616325) PREDICTE ( 879) 876 73.8 4.3e-12 XP_016877741 (OMIM: 191316) PREDICTED: NT-3 growth ( 448) 827 70.3 2.5e-11 XP_016877740 (OMIM: 191316) PREDICTED: NT-3 growth ( 456) 827 70.3 2.6e-11 XP_016877733 (OMIM: 191316) PREDICTED: NT-3 growth ( 727) 827 70.5 3.4e-11 XP_016877734 (OMIM: 191316) PREDICTED: NT-3 growth ( 727) 827 70.5 3.4e-11 XP_016877735 (OMIM: 191316) PREDICTED: NT-3 growth ( 727) 827 70.5 3.4e-11 XP_016877732 (OMIM: 191316) PREDICTED: NT-3 growth ( 727) 827 70.5 3.4e-11 XP_016877730 (OMIM: 191316) PREDICTED: NT-3 growth ( 763) 827 70.6 3.5e-11 NP_001230030 (OMIM: 191316) NT-3 growth factor rec ( 817) 827 70.6 3.7e-11 XP_006720607 (OMIM: 191316) PREDICTED: NT-3 growth ( 817) 827 70.6 3.7e-11 NP_002521 (OMIM: 191316) NT-3 growth factor recept ( 825) 827 70.6 3.7e-11 XP_006720606 (OMIM: 191316) PREDICTED: NT-3 growth ( 825) 827 70.6 3.7e-11 XP_016877729 (OMIM: 191316) PREDICTED: NT-3 growth ( 825) 827 70.6 3.7e-11 XP_011517020 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 820 70.1 5.1e-11 XP_016870243 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 820 70.1 5.1e-11 XP_016870241 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 820 70.1 5.1e-11 XP_016870242 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 820 70.1 5.1e-11 NP_001018074 (OMIM: 600456,613886) BDNF/NT-3 growt ( 822) 820 70.1 5.1e-11 NP_006171 (OMIM: 600456,613886) BDNF/NT-3 growth f ( 838) 820 70.2 5.1e-11 XP_005252058 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 820 70.2 5.1e-11 XP_016870240 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 820 70.2 5.1e-11 XP_005252060 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 820 70.2 5.1e-11 XP_005252061 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 820 70.2 5.1e-11 NP_001007793 (OMIM: 155240,191315,256800) high aff ( 760) 795 68.5 1.5e-10 NP_001012331 (OMIM: 155240,191315,256800) high aff ( 790) 795 68.5 1.5e-10 NP_002520 (OMIM: 155240,191315,256800) high affini ( 796) 795 68.5 1.5e-10 NP_001278909 (OMIM: 134935) fibroblast growth fact ( 734) 698 62.2 1.1e-08 XP_011507889 (OMIM: 191311,271665) PREDICTED: disc ( 855) 695 62.1 1.4e-08 NP_006173 (OMIM: 191311,271665) discoidin domain-c ( 855) 695 62.1 1.4e-08 XP_011507888 (OMIM: 191311,271665) PREDICTED: disc ( 855) 695 62.1 1.4e-08 NP_001014796 (OMIM: 191311,271665) discoidin domai ( 855) 695 62.1 1.4e-08 >>NP_004551 (OMIM: 113000,268310,602337) tyrosine-protei (943 aa) initn: 6520 init1: 6520 opt: 6520 Z-score: 2315.3 bits: 439.8 E(85289): 3.2e-122 Smith-Waterman score: 6520; 99.8% identity (100.0% similar) in 943 aa overlap (1-943:1-943) 10 20 30 40 50 60 pF1KE3 MARGSALPRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MARGSALPRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 FLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 FLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 RIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 ACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 ARSRAPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANC ::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANC 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 MRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 GHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIAC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 LFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 EDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 GVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 AGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 PEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAW 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 VYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSN 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 VSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYIPVNGYQPVPAYGAYLPNFYPV ::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::: NP_004 VSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFYPV 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 QIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNA 850 860 870 880 890 900 910 920 930 940 pF1KE3 PEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA ::::::::::::::::::::::::::::::::::::::::::: NP_004 PEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA 910 920 930 940 >>XP_016870251 (OMIM: 113000,268310,602337) PREDICTED: t (940 aa) initn: 6314 init1: 6314 opt: 6318 Z-score: 2244.6 bits: 426.7 E(85289): 2.8e-118 Smith-Waterman score: 6318; 98.0% identity (98.7% similar) in 933 aa overlap (12-943:8-940) 10 20 30 40 50 pF1KE3 MARGSALPRRPLLCIPAVWAAAALLLSVSR-TSGEVEVLDPNDPLGPLDGQDGPIPTLKG :.:. .. . ::: ::::::::::::::::::::::::::: XP_016 MCLLGTFLVCVETLGFGCISSSSVSYYIFGEVEVLDPNDPLGPLDGQDGPIPTLKG 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 YFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSR 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 LRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 IACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLC 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 DARSRAPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAAN :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAAN 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 CMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELG 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE3 GGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIA 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE3 CLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEEL 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE3 GEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCL 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE3 LGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQI 540 550 560 570 580 590 600 610 620 630 640 650 pF1KE3 AAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWM 600 610 620 630 640 650 660 670 680 690 700 710 pF1KE3 APEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPA 660 670 680 690 700 710 720 730 740 750 760 770 pF1KE3 WVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVS 720 730 740 750 760 770 780 790 800 810 820 830 pF1KE3 NVSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYIPVNGYQPVPAYGAYLPNFYP :::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::: XP_016 NVSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFYP 780 790 800 810 820 830 840 850 860 870 880 890 pF1KE3 VQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQN 840 850 860 870 880 890 900 910 920 930 940 pF1KE3 APEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA :::::::::::::::::::::::::::::::::::::::::::: XP_016 APEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA 900 910 920 930 940 >>XP_005252065 (OMIM: 113000,268310,602337) PREDICTED: t (803 aa) initn: 5567 init1: 5567 opt: 5567 Z-score: 1982.2 bits: 377.9 E(85289): 1.1e-103 Smith-Waterman score: 5567; 99.8% identity (100.0% similar) in 803 aa overlap (141-943:1-803) 120 130 140 150 160 170 pF1KE3 IRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHE :::::::::::::::::::::::::::::: XP_005 MKTITATGVLFVRLGPTHSPNHNFQDDYHE 10 20 30 180 190 200 210 220 230 pF1KE3 DGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPS 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE3 FCHFVFPLCDARSRAPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALP ::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: XP_005 FCHFVFPLCDARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALP 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE3 MPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHL 160 170 180 190 200 210 360 370 380 390 400 410 pF1KE3 SSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVP 220 230 240 250 260 270 420 430 440 450 460 470 pF1KE3 SIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISL 280 290 300 310 320 330 480 490 500 510 520 530 pF1KE3 SAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRAR 340 350 360 370 380 390 540 550 560 570 580 590 pF1KE3 LQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPP 400 410 420 430 440 450 600 610 620 630 640 650 pF1KE3 DFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLG 460 470 480 490 500 510 660 670 680 690 700 710 pF1KE3 NSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQV 520 530 540 550 560 570 720 730 740 750 760 770 pF1KE3 LPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQT 580 590 600 610 620 630 780 790 800 810 820 830 pF1KE3 SSLSTSPVSNVSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYIPVNGYQPVPAY ::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::: XP_005 SSLSTSPVSNVSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAY 640 650 660 670 680 690 840 850 860 870 880 890 pF1KE3 GAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALL 700 710 720 730 740 750 900 910 920 930 940 pF1KE3 SEGADDTQNAPEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SEGADDTQNAPEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA 760 770 780 790 800 >>XP_016870252 (OMIM: 113000,268310,602337) PREDICTED: t (803 aa) initn: 5567 init1: 5567 opt: 5567 Z-score: 1982.2 bits: 377.9 E(85289): 1.1e-103 Smith-Waterman score: 5567; 99.8% identity (100.0% similar) in 803 aa overlap (141-943:1-803) 120 130 140 150 160 170 pF1KE3 IRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHE :::::::::::::::::::::::::::::: XP_016 MKTITATGVLFVRLGPTHSPNHNFQDDYHE 10 20 30 180 190 200 210 220 230 pF1KE3 DGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPS 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE3 FCHFVFPLCDARSRAPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALP ::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: XP_016 FCHFVFPLCDARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALP 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE3 MPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHL 160 170 180 190 200 210 360 370 380 390 400 410 pF1KE3 SSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVP 220 230 240 250 260 270 420 430 440 450 460 470 pF1KE3 SIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISL 280 290 300 310 320 330 480 490 500 510 520 530 pF1KE3 SAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRAR 340 350 360 370 380 390 540 550 560 570 580 590 pF1KE3 LQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPP 400 410 420 430 440 450 600 610 620 630 640 650 pF1KE3 DFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLG 460 470 480 490 500 510 660 670 680 690 700 710 pF1KE3 NSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQV 520 530 540 550 560 570 720 730 740 750 760 770 pF1KE3 LPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQT 580 590 600 610 620 630 780 790 800 810 820 830 pF1KE3 SSLSTSPVSNVSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYIPVNGYQPVPAY ::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::: XP_016 SSLSTSPVSNVSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAY 640 650 660 670 680 690 840 850 860 870 880 890 pF1KE3 GAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALL 700 710 720 730 740 750 900 910 920 930 940 pF1KE3 SEGADDTQNAPEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEGADDTQNAPEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA 760 770 780 790 800 >>XP_006717184 (OMIM: 113000,268310,602337) PREDICTED: t (803 aa) initn: 5567 init1: 5567 opt: 5567 Z-score: 1982.2 bits: 377.9 E(85289): 1.1e-103 Smith-Waterman score: 5567; 99.8% identity (100.0% similar) in 803 aa overlap (141-943:1-803) 120 130 140 150 160 170 pF1KE3 IRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHE :::::::::::::::::::::::::::::: XP_006 MKTITATGVLFVRLGPTHSPNHNFQDDYHE 10 20 30 180 190 200 210 220 230 pF1KE3 DGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPS 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE3 FCHFVFPLCDARSRAPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALP ::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: XP_006 FCHFVFPLCDARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALP 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE3 MPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHL 160 170 180 190 200 210 360 370 380 390 400 410 pF1KE3 SSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVP 220 230 240 250 260 270 420 430 440 450 460 470 pF1KE3 SIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISL 280 290 300 310 320 330 480 490 500 510 520 530 pF1KE3 SAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRAR 340 350 360 370 380 390 540 550 560 570 580 590 pF1KE3 LQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPP 400 410 420 430 440 450 600 610 620 630 640 650 pF1KE3 DFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLG 460 470 480 490 500 510 660 670 680 690 700 710 pF1KE3 NSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQV 520 530 540 550 560 570 720 730 740 750 760 770 pF1KE3 LPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQT 580 590 600 610 620 630 780 790 800 810 820 830 pF1KE3 SSLSTSPVSNVSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYIPVNGYQPVPAY ::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::: XP_006 SSLSTSPVSNVSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAY 640 650 660 670 680 690 840 850 860 870 880 890 pF1KE3 GAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALL 700 710 720 730 740 750 900 910 920 930 940 pF1KE3 SEGADDTQNAPEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SEGADDTQNAPEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA 760 770 780 790 800 >>XP_005252066 (OMIM: 113000,268310,602337) PREDICTED: t (542 aa) initn: 3682 init1: 3682 opt: 3682 Z-score: 1323.6 bits: 255.5 E(85289): 5.5e-67 Smith-Waterman score: 3682; 99.8% identity (100.0% similar) in 542 aa overlap (402-943:1-542) 380 390 400 410 420 430 pF1KE3 MEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIACLFFLVCMCRNK :::::::::::::::::::::::::::::: XP_005 MGILYILVPSIAIPLVIACLFFLVCMCRNK 10 20 30 440 450 460 470 480 490 pF1KE3 QKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELGEDRFGKVYKGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELGEDRFGKVYKGH 40 50 60 70 80 90 500 510 520 530 540 550 pF1KE3 LFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSM 100 110 120 130 140 150 560 570 580 590 600 610 pF1KE3 IFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHV 160 170 180 190 200 210 620 630 640 650 660 670 pF1KE3 VHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSI 220 230 240 250 260 270 680 690 700 710 720 730 pF1KE3 DSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNE 280 290 300 310 320 330 740 750 760 770 780 790 pF1KE3 FPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYVGPKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYVGPKQ 340 350 360 370 380 390 800 810 820 830 840 850 pF1KE3 KAPPFPQPQFIPMKGQIRPMVPPPQLYIPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQV :::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::: XP_005 KAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQV 400 410 420 430 440 450 860 870 880 890 900 910 pF1KE3 PPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNAPEDGAQSTVQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNAPEDGAQSTVQE 460 470 480 490 500 510 920 930 940 pF1KE3 AEEEEEGSVPETELLGDCDTLQVDEAQVQLEA :::::::::::::::::::::::::::::::: XP_005 AEEEEEGSVPETELLGDCDTLQVDEAQVQLEA 520 530 540 >>NP_005003 (OMIM: 602336) inactive tyrosine-protein kin (937 aa) initn: 2749 init1: 1334 opt: 3657 Z-score: 1312.2 bits: 254.1 E(85289): 2.4e-66 Smith-Waterman score: 3657; 57.6% identity (79.1% similar) in 946 aa overlap (8-942:4-936) 10 20 30 40 50 60 pF1KE3 MARGSALPRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGY ::: : . :::::.. .... :. . : : .. . : NP_005 MHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDS 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 FLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRL .:.. ::.:::: :::: :::::.:::::..::.::::::::::::. .:.: ::::: NP_005 YLTLDEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 RIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGI ::..::::::::.::::::: .....::::::..:: . . ...:.:.::::::::::: NP_005 RIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGI 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 ACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCD ::::::::::.:..::.:::::::.:::::::::::.::::.::::::::.::..:: :: NP_005 ACARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCD 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE3 ARSRAPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANC : .::::.:::::::.::. ::. :: .:::::.:::::.::.:: ::.::::.:::: NP_005 ETSSVPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANC 240 250 260 270 280 290 310 320 330 340 350 pF1KE3 MRIGIP-AERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELG .::::: :. ... :.:::..:.:::::.:.::::.::::: :.::.: ... ::::. NP_005 IRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELN 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE3 GGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDS---SKMGILYILVPSIAIPL :::.::::::.: :.::::: ..: . .:::.:.:. .:: .:: ::::::::.:::: NP_005 GGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPL 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE3 VIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHK-QAKLKEISLSAVRF .:: :::..:.:::.:: :.:.: .:: .:..:: ..: .: ..: ::. :::::: NP_005 AIALLFFFICVCRNNQK-SSSAPVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRF 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE3 MEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPN :::::: :::.:::::. :. ...: :::::::: . ::..:: : :.:.::: NP_005 MEELGECAFGKIYKGHLYLPGM-DHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPN 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE3 VVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVG-STDDDRTVKSALEPPDFVH .:::::.::..::. :.: : ..:::::::.::::::::: :.:.: ::::.:. ::.: NP_005 IVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLH 540 550 560 570 580 590 600 610 620 630 640 650 pF1KE3 LVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLL .. :::::::::::: ::::::.::.:. ..:.:::::::: ::.:.::::.. ..::: NP_005 IAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLL 600 610 620 630 640 650 660 670 680 690 700 710 pF1KE3 PIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCP ::::: :::::::::: ::::::.::::::.::.::::: :.:::.:.::.:.::.::: NP_005 PIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCS 660 670 680 690 700 710 720 730 740 750 760 770 pF1KE3 DDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLS .::: .:.:: :::::.::::::::::: :::.: .::...::. ::.. ::::.::: NP_005 EDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLS 720 730 740 750 760 770 780 790 800 810 820 830 pF1KE3 TSPVSNVSNARYVGPKQKAPP---FPQPQFIPMKGQIRPMVPPPQLYIPVNGYQPVPAYG .:::::.:: :: :. : :: : . : : : .: : .::.::: :.:. NP_005 ASPVSNLSNPRY--PNYMFPSQGITPQGQ---IAGFIGPPIPQNQRFIPINGYPIPPGYA 780 790 800 810 820 840 850 860 870 880 890 pF1KE3 AYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLS :. : : .. :. :: :: : :.:::::::.::. ::. : . : NP_005 AFPAAHYQPTGPPRVI-QHCPP---PKSRSPSSASGSTSTGHVTSLPSSGSNQEANIPLL 830 840 850 860 870 880 900 910 920 930 940 pF1KE3 EGADDTQNAPEDGAQSTV--QEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA . : : : :: ..... . . .. :::: . :.... : NP_005 PHMS-IPNHP-GGMGITVFGNKSQKPYKIDSKQASLLGDANIHGHTESMISAEL 890 900 910 920 930 >>XP_016856865 (OMIM: 602336) PREDICTED: inactive tyrosi (917 aa) initn: 2725 init1: 1315 opt: 3642 Z-score: 1307.1 bits: 253.2 E(85289): 4.6e-66 Smith-Waterman score: 3642; 59.4% identity (80.7% similar) in 902 aa overlap (53-942:28-916) 30 40 50 60 70 80 pF1KE3 ALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTL-KGYFLNFLEPVNNITIVQGQTAIL : :.: : .:.. ::.:::: :::: : XP_016 MMLLPTESLLSLTKVSIHFIIPFLACFPDPSLIKDSYLTLDEPMNNITTSLGQTAEL 10 20 30 40 50 90 100 110 120 130 140 pF1KE3 HCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGM ::::.:::::..::.::::::::::::. .:.: :::::::..::::::::.::::::: XP_016 HCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGK 60 70 80 90 100 110 150 160 170 180 190 200 pF1KE3 KTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGE .....::::::..:: . . ...:.:.:::::::::::::::::::::.:..::.:::: XP_016 EVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGE 120 130 140 150 160 170 210 220 230 240 250 260 pF1KE3 IENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRAPKPRELCRDECEVLES :::.:::::::::::.::::.::::::::.::..:: :: : .::::.:::::::.::. XP_016 IENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEILEN 180 190 200 210 220 230 270 280 290 300 310 320 pF1KE3 DLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIP-AERLGRYHQCYNGS ::. :: .:::::.:::::.::.:: ::.::::.::::.::::: :. ... :.:::.. XP_016 VLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIGIPMADPINKNHKCYNST 240 250 260 270 280 290 330 340 350 360 370 380 pF1KE3 GMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQ :.:::::.:.::::.::::: :.::.: ... ::::.:::.::::::.: :.::::: XP_016 GVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCRNPGNQKEAPWCFTL 300 310 320 330 340 350 390 400 410 420 430 pF1KE3 NKNVRMELCDVPSCSPRDS---SKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASAS ..: . .:::.:.:. .:: .:: ::::::::.::::.:: :::..:.:::.:: :.: XP_016 DENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIALLFFFICVCRNNQK-SSS 360 370 380 390 400 410 440 450 460 470 480 490 pF1KE3 TPQRRQLMASPSQDMEMPLINQHK-QAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPA .: .:: .:..:: ..: .: ..: ::. :::::::::::: :::.:::::. :. XP_016 APVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLYLPG 420 430 440 450 460 470 500 510 520 530 540 550 pF1KE3 PGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYC ...: :::::::: . ::..:: : :.:.:::.:::::.::..::. :.: : XP_016 M-DHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYI 480 490 500 510 520 530 560 570 580 590 600 610 pF1KE3 SHGDLHEFLVMRSPHSDVG-STDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKD ..:::::::.::::::::: :.:.: ::::.:. ::.:.. :::::::::::: :::: XP_016 NQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKD 540 550 560 570 580 590 620 630 640 650 660 670 pF1KE3 LATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDI ::.::.:. ..:.:::::::: ::.:.::::.. ..:::::::: :::::::::: :::: XP_016 LAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDI 600 610 620 630 640 650 680 690 700 710 720 730 pF1KE3 WSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSR ::.::::::.::.::::: :.:::.:.::.:.::.::: .::: .:.:: :::::.::: XP_016 WSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSR 660 670 680 690 700 710 740 750 760 770 780 790 pF1KE3 RPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYVGPKQKAPP :::::::: :::.: .::...::. ::.. ::::.:::.:::::.:: :: :. : XP_016 RPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSNLSNPRY--PNYMFPS 720 730 740 750 760 770 800 810 820 830 840 850 pF1KE3 ---FPQPQFIPMKGQIRPMVPPPQLYIPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQVP :: : . : : : .: : .::.::: :.:.:. : : .. :. : XP_016 QGITPQGQ---IAGFIGPPIPQNQRFIPINGYPIPPGYAAFPAAHYQPTGPPRVI-QHCP 780 790 800 810 820 860 870 880 890 900 910 pF1KE3 PQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNAPEDGAQSTV--Q : :: : :.:::::::.::. ::. : . : . : : : :: . XP_016 P---PKSRSPSSASGSTSTGHVTSLPSSGSNQEANIPLLPHMS-IPNHP-GGMGITVFGN 830 840 850 860 870 880 920 930 940 pF1KE3 EAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA .... . . .. :::: . :.... : XP_016 KSQKPYKIDSKQASLLGDANIHGHTESMISAEL 890 900 910 >>XP_011539828 (OMIM: 602336) PREDICTED: inactive tyrosi (874 aa) initn: 2698 init1: 1315 opt: 3606 Z-score: 1294.7 bits: 250.8 E(85289): 2.2e-65 Smith-Waterman score: 3606; 59.7% identity (80.9% similar) in 886 aa overlap (68-942:1-873) 40 50 60 70 80 90 pF1KE3 LDPNDPLGPLDGQDGPIPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLK .:::: :::: :::::.:::::..::.: XP_011 MNNITTSLGQTAELHCKVSGNPPPTIRWFK 10 20 30 100 110 120 130 140 150 pF1KE3 NDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPT :::::::::::. .:.: :::::::..::::::::.::::::: .....::::::..:: XP_011 NDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPP 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE3 HSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTST . . ...:.:.:::::::::::::::::::::.:..::.:::::::.:::::::::::. XP_011 PTASPGYSDEYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSS 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE3 HLSDQCSQFAIPSFCHFVFPLCDARSRAPKPRELCRDECEVLESDLCRQEYTIARSNPLI ::::.::::::::.::..:: :: : .::::.:::::::.::. ::. :: .:::::.: XP_011 HLSDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEILENVLCQTEYIFARSNPMI 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE3 LMRLQLPKCEALPMPESPDAANCMRIGIP-AERLGRYHQCYNGSGMDYRGTASTTKSGHQ ::::.::.:: ::.::::.::::.::::: :. ... :.:::..:.:::::.:.::::.: XP_011 LMRLKLPNCEDLPQPESPEAANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQ 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE3 CQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSP :::: :.::.: ... ::::.:::.::::::.: :.::::: ..: . .:::.:.:. XP_011 CQPWNSQYPHTHTFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACDS 280 290 300 310 320 330 400 410 420 430 440 450 pF1KE3 RDS---SKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDME .:: .:: ::::::::.::::.:: :::..:.:::.::.: :.: .:: .:..: XP_011 KDSKEKNKMEILYILVPSVAIPLAIALLFFFICVCRNNQKSS-SAPVQRQPKHVRGQNVE 340 350 360 370 380 460 470 480 490 500 510 pF1KE3 MPLINQHK-QAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDK : ..: .: ..: ::. :::::::::::: :::.:::::. :. ...: :::::::: XP_011 MSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLYLPGM-DHAQLVAIKTLKDY 390 400 410 420 430 440 520 530 540 550 560 570 pF1KE3 AEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHS . ::..:: : :.:.:::.:::::.::..::. :.: : ..:::::::.:::::: XP_011 NNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHS 450 460 470 480 490 500 580 590 600 610 620 630 pF1KE3 DVG-STDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKI ::: :.:.: ::::.:. ::.:.. :::::::::::: ::::::.::.:. ..:.::: XP_011 DVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKI 510 520 530 540 550 560 640 650 660 670 680 690 pF1KE3 SDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQ ::::: ::.:.::::.. ..:::::::: :::::::::: ::::::.::::::.::.::: XP_011 SDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQ 570 580 590 600 610 620 700 710 720 730 740 750 pF1KE3 PYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGN :: :.:::.:.::.:.::.::: .::: .:.:: :::::.::::::::::: :::.: . XP_011 PYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWEG 630 640 650 660 670 680 760 770 780 790 800 pF1KE3 LSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYVGPKQKAPP---FPQPQFIPMKGQI ::...::. ::.. ::::.:::.:::::.:: :: :. : :: : . : : XP_011 LSSHTSSTTPSGGNATTQTTSLSASPVSNLSNPRY--PNYMFPSQGITPQGQ---IAGFI 690 700 710 720 730 740 810 820 830 840 850 860 pF1KE3 RPMVPPPQLYIPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGS : .: : .::.::: :.:.:. : : .. :. :: :: : :.::: XP_011 GPPIPQNQRFIPINGYPIPPGYAAFPAAHYQPTGPPRVI-QHCPP---PKSRSPSSASGS 750 760 770 780 790 870 880 890 900 910 920 pF1KE3 TSTGYVTTAPSNTSMADRAALLSEGADDTQNAPEDGAQSTV--QEAEEEEEGSVPETELL ::::.::. ::. : . : . : : : :: ..... . . .. :: XP_011 TSTGHVTSLPSSGSNQEANIPLLPHMS-IPNHP-GGMGITVFGNKSQKPYKIDSKQASLL 800 810 820 830 840 850 930 940 pF1KE3 GDCDTLQVDEAQVQLEA :: . :.... : XP_011 GDANIHGHTESMISAEL 860 870 >>XP_016856866 (OMIM: 602336) PREDICTED: inactive tyrosi (874 aa) initn: 2698 init1: 1315 opt: 3606 Z-score: 1294.7 bits: 250.8 E(85289): 2.2e-65 Smith-Waterman score: 3606; 59.7% identity (80.9% similar) in 886 aa overlap (68-942:1-873) 40 50 60 70 80 90 pF1KE3 LDPNDPLGPLDGQDGPIPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLK .:::: :::: :::::.:::::..::.: XP_016 MNNITTSLGQTAELHCKVSGNPPPTIRWFK 10 20 30 100 110 120 130 140 150 pF1KE3 NDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPT :::::::::::. .:.: :::::::..::::::::.::::::: .....::::::..:: XP_016 NDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPP 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE3 HSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTST . . ...:.:.:::::::::::::::::::::.:..::.:::::::.:::::::::::. XP_016 PTASPGYSDEYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSS 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE3 HLSDQCSQFAIPSFCHFVFPLCDARSRAPKPRELCRDECEVLESDLCRQEYTIARSNPLI ::::.::::::::.::..:: :: : .::::.:::::::.::. ::. :: .:::::.: XP_016 HLSDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEILENVLCQTEYIFARSNPMI 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE3 LMRLQLPKCEALPMPESPDAANCMRIGIP-AERLGRYHQCYNGSGMDYRGTASTTKSGHQ ::::.::.:: ::.::::.::::.::::: :. ... :.:::..:.:::::.:.::::.: XP_016 LMRLKLPNCEDLPQPESPEAANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQ 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE3 CQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSP :::: :.::.: ... ::::.:::.::::::.: :.::::: ..: . .:::.:.:. XP_016 CQPWNSQYPHTHTFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACDS 280 290 300 310 320 330 400 410 420 430 440 450 pF1KE3 RDS---SKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDME .:: .:: ::::::::.::::.:: :::..:.:::.::.: :.: .:: .:..: XP_016 KDSKEKNKMEILYILVPSVAIPLAIALLFFFICVCRNNQKSS-SAPVQRQPKHVRGQNVE 340 350 360 370 380 460 470 480 490 500 510 pF1KE3 MPLINQHK-QAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDK : ..: .: ..: ::. :::::::::::: :::.:::::. :. ...: :::::::: XP_016 MSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLYLPGM-DHAQLVAIKTLKDY 390 400 410 420 430 440 520 530 540 550 560 570 pF1KE3 AEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHS . ::..:: : :.:.:::.:::::.::..::. :.: : ..:::::::.:::::: XP_016 NNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHS 450 460 470 480 490 500 580 590 600 610 620 630 pF1KE3 DVG-STDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKI ::: :.:.: ::::.:. ::.:.. :::::::::::: ::::::.::.:. ..:.::: XP_016 DVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKI 510 520 530 540 550 560 640 650 660 670 680 690 pF1KE3 SDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQ ::::: ::.:.::::.. ..:::::::: :::::::::: ::::::.::::::.::.::: XP_016 SDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQ 570 580 590 600 610 620 700 710 720 730 740 750 pF1KE3 PYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGN :: :.:::.:.::.:.::.::: .::: .:.:: :::::.::::::::::: :::.: . XP_016 PYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWEG 630 640 650 660 670 680 760 770 780 790 800 pF1KE3 LSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYVGPKQKAPP---FPQPQFIPMKGQI ::...::. ::.. ::::.:::.:::::.:: :: :. : :: : . : : XP_016 LSSHTSSTTPSGGNATTQTTSLSASPVSNLSNPRY--PNYMFPSQGITPQGQ---IAGFI 690 700 710 720 730 740 810 820 830 840 850 860 pF1KE3 RPMVPPPQLYIPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGS : .: : .::.::: :.:.:. : : .. :. :: :: : :.::: XP_016 GPPIPQNQRFIPINGYPIPPGYAAFPAAHYQPTGPPRVI-QHCPP---PKSRSPSSASGS 750 760 770 780 790 870 880 890 900 910 920 pF1KE3 TSTGYVTTAPSNTSMADRAALLSEGADDTQNAPEDGAQSTV--QEAEEEEEGSVPETELL ::::.::. ::. : . : . : : : :: ..... . . .. :: XP_016 TSTGHVTSLPSSGSNQEANIPLLPHMS-IPNHP-GGMGITVFGNKSQKPYKIDSKQASLL 800 810 820 830 840 850 930 940 pF1KE3 GDCDTLQVDEAQVQLEA :: . :.... : XP_016 GDANIHGHTESMISAEL 860 870 943 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 19:44:24 2016 done: Sun Nov 6 19:44:26 2016 Total Scan time: 12.650 Total Display time: 0.390 Function used was FASTA [36.3.4 Apr, 2011]