FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3355, 1047 aa 1>>>pF1KE3355 1047 - 1047 aa - 1047 aa Library: /omim/omim.rfq.tfa 64848753 residues in 91609 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.9673+/-0.000623; mu= 3.4614+/- 0.037 mean_var=512.7882+/-125.399, 0's: 0 Z-trim(112.6): 420 B-trim: 1013 in 1/52 Lambda= 0.056638 statistics sampled from 21967 (22391) to 21967 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.59), E-opt: 0.2 (0.244), width: 16 Scan time: 6.810 The best scores are: opt bits E(91609) NP_003986 (OMIM: 108961,602875,615923,616255) atri (1047) 7020 591.2 1.1e-167 XP_005251535 (OMIM: 108961,602875,615923,616255) a (1050) 7004 589.9 2.7e-167 XP_024303325 (OMIM: 108961,602875,615923,616255) a (1100) 4608 394.1 2.4e-108 XP_024303324 (OMIM: 108961,602875,615923,616255) a (1103) 4592 392.8 6e-108 NP_000897 (OMIM: 108960) atrial natriuretic peptid (1061) 4181 359.2 7.6e-98 XP_024303329 (OMIM: 108961,602875,615923,616255) a ( 579) 3838 330.7 1.5e-89 XP_005245275 (OMIM: 108960) atrial natriuretic pep (1035) 2520 223.5 5.4e-57 XP_024303328 (OMIM: 108961,602875,615923,616255) a ( 632) 2427 215.5 8.1e-55 XP_024303327 (OMIM: 108961,602875,615923,616255) a ( 635) 2427 215.5 8.1e-55 XP_024303326 (OMIM: 108961,602875,615923,616255) a ( 774) 2427 215.6 9e-55 XP_016856863 (OMIM: 108960) atrial natriuretic pep ( 704) 2269 202.7 6.6e-51 NP_001513 (OMIM: 300041) retinal guanylyl cyclase (1108) 1712 157.5 4.2e-37 XP_011522118 (OMIM: 204000,215500,600179,601777) r (1103) 1677 154.6 3e-36 NP_000171 (OMIM: 204000,215500,600179,601777) reti (1103) 1677 154.6 3e-36 XP_011518933 (OMIM: 601330,614616,614665) heat-sta ( 991) 1411 132.8 1e-29 NP_004954 (OMIM: 601330,614616,614665) heat-stable (1073) 1411 132.9 1e-29 NP_000846 (OMIM: 601244) guanylate cyclase soluble ( 732) 604 66.7 6.1e-10 XP_005263013 (OMIM: 139396,615750) guanylate cycla ( 455) 582 64.5 1.7e-09 NP_001124157 (OMIM: 139396,615750) guanylate cycla ( 455) 582 64.5 1.7e-09 XP_005263014 (OMIM: 139396,615750) guanylate cycla ( 455) 582 64.5 1.7e-09 XP_011530202 (OMIM: 139396,615750) guanylate cycla ( 455) 582 64.5 1.7e-09 NP_001243378 (OMIM: 139396,615750) guanylate cycla ( 690) 582 64.8 2e-09 XP_006714259 (OMIM: 139396,615750) guanylate cycla ( 690) 582 64.8 2e-09 NP_001124156 (OMIM: 139396,615750) guanylate cycla ( 690) 582 64.8 2e-09 XP_005263012 (OMIM: 139396,615750) guanylate cycla ( 690) 582 64.8 2e-09 XP_006714260 (OMIM: 139396,615750) guanylate cycla ( 690) 582 64.8 2e-09 NP_000847 (OMIM: 139396,615750) guanylate cyclase ( 690) 582 64.8 2e-09 NP_001124154 (OMIM: 139396,615750) guanylate cycla ( 690) 582 64.8 2e-09 NP_001124155 (OMIM: 139396,615750) guanylate cycla ( 690) 582 64.8 2e-09 NP_001124159 (OMIM: 139396,615750) guanylate cycla ( 624) 577 64.3 2.6e-09 XP_016863622 (OMIM: 139397) guanylate cyclase solu ( 551) 569 63.6 3.8e-09 NP_001278884 (OMIM: 139397) guanylate cyclase solu ( 551) 569 63.6 3.8e-09 XP_016863621 (OMIM: 139397) guanylate cyclase solu ( 551) 569 63.6 3.8e-09 NP_001278881 (OMIM: 139397) guanylate cyclase solu ( 599) 569 63.6 4e-09 NP_000848 (OMIM: 139397) guanylate cyclase soluble ( 619) 569 63.7 4e-09 NP_001278880 (OMIM: 139397) guanylate cyclase solu ( 641) 569 63.7 4.1e-09 NP_001278882 (OMIM: 139397) guanylate cyclase solu ( 594) 539 61.2 2.2e-08 XP_016863620 (OMIM: 139397) guanylate cyclase solu ( 594) 539 61.2 2.2e-08 XP_016863619 (OMIM: 139397) guanylate cyclase solu ( 594) 539 61.2 2.2e-08 XP_011530203 (OMIM: 139397) guanylate cyclase solu ( 662) 539 61.3 2.3e-08 NP_000899 (OMIM: 108962) atrial natriuretic peptid ( 540) 509 58.7 1.1e-07 NP_001191304 (OMIM: 108962) atrial natriuretic pep ( 541) 509 58.7 1.1e-07 NP_001278883 (OMIM: 139397) guanylate cyclase solu ( 586) 436 52.8 7.3e-06 NP_001243353 (OMIM: 601244) guanylate cyclase solu ( 763) 415 51.2 2.8e-05 XP_011512352 (OMIM: 108962) atrial natriuretic pep ( 272) 399 49.2 4e-05 XP_016864981 (OMIM: 108962) atrial natriuretic pep ( 500) 397 49.5 6.2e-05 NP_003812 (OMIM: 603455) receptor-interacting seri ( 540) 364 46.8 0.00042 NP_848605 (OMIM: 608774) ankyrin repeat and protei ( 765) 357 46.5 0.00074 XP_011541039 (OMIM: 608774) ankyrin repeat and pro ( 766) 357 46.5 0.00074 XP_016858682 (OMIM: 600291,617885) adenylate cycla ( 903) 355 46.5 0.0009 >>NP_003986 (OMIM: 108961,602875,615923,616255) atrial n (1047 aa) initn: 7020 init1: 7020 opt: 7020 Z-score: 3132.0 bits: 591.2 E(91609): 1.1e-167 Smith-Waterman score: 7020; 100.0% identity (100.0% similar) in 1047 aa overlap (1-1047:1-1047) 10 20 30 40 50 60 pF1KE3 MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 PVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 TAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 YFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 YFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 QRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYRE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 PPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTRED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTRED 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 GLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWW 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 TGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 LMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 GHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 RGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKI 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 TDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALR 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 SGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 QIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPH 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 SVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNF 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE3 DVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGV 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE3 HTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 HTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELR 970 980 990 1000 1010 1020 1030 1040 pF1KE3 GDVEMKGKGKMRTYWLLGERKGPPGLL ::::::::::::::::::::::::::: NP_003 GDVEMKGKGKMRTYWLLGERKGPPGLL 1030 1040 >>XP_005251535 (OMIM: 108961,602875,615923,616255) atria (1050 aa) initn: 3778 init1: 3778 opt: 7004 Z-score: 3124.9 bits: 589.9 E(91609): 2.7e-167 Smith-Waterman score: 7004; 99.7% identity (99.7% similar) in 1050 aa overlap (1-1047:1-1050) 10 20 30 40 50 60 pF1KE3 MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 PVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 TAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 YFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 QRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYRE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 PPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTRED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTRED 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 GLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWW 370 380 390 400 410 420 430 440 450 460 470 pF1KE3 TGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFR- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE3 --KLMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YRKLMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIF 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE3 ANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTE 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE3 YCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFV 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE3 LKITDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKITDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEI 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE3 ALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERP 730 740 750 760 770 780 780 790 800 810 820 830 pF1KE3 DFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQI 790 800 810 820 830 840 840 850 860 870 880 890 pF1KE3 LPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAII 850 860 870 880 890 900 900 910 920 930 940 950 pF1KE3 DNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLR 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KE3 IGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQL 970 980 990 1000 1010 1020 1020 1030 1040 pF1KE3 ELRGDVEMKGKGKMRTYWLLGERKGPPGLL :::::::::::::::::::::::::::::: XP_005 ELRGDVEMKGKGKMRTYWLLGERKGPPGLL 1030 1040 1050 >>XP_024303325 (OMIM: 108961,602875,615923,616255) atria (1100 aa) initn: 4608 init1: 4608 opt: 4608 Z-score: 2066.6 bits: 394.1 E(91609): 2.4e-108 Smith-Waterman score: 6746; 95.0% identity (95.1% similar) in 1079 aa overlap (1-1026:1-1079) 10 20 30 40 50 60 pF1KE3 MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 PVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 PVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 TAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 TAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 YFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 YFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 QRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 QRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYRE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 PPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTRED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 PPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTRED 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 GLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 GLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWW 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 TGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 TGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 LMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 LMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 GHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 GHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 RGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 RGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKI 610 620 630 640 650 660 670 680 pF1KE3 TDYGLASFRSTAEPDDSHALYA-------------------------------------- :::::::::::::::::::::: XP_024 TDYGLASFRSTAEPDDSHALYASEAHPHNPLFILLLFPPRDGGRGRWSDSNIGMSPGGLG 670 680 690 700 710 720 690 700 710 720 pF1KE3 ---------------KKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLE .:::::::::::::::::::::::::::::::::::::::::::: XP_024 GAPFRGTWPAGFLFSEKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLE 730 740 750 760 770 780 730 740 750 760 770 780 pF1KE3 GLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIKGFIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 GLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIKGFIR 790 800 810 820 830 840 790 800 810 820 830 840 pF1KE3 RFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 RFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLK 850 860 870 880 890 900 850 860 870 880 890 900 pF1KE3 RGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 RGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVET 910 920 930 940 950 960 910 920 930 940 950 960 pF1KE3 IGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 IGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCA 970 980 990 1000 1010 1020 970 980 990 1000 1010 1020 pF1KE3 GVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 GVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKG 1030 1040 1050 1060 1070 1080 1030 1040 pF1KE3 KGKMRTYWLLGERKGPPGLL XP_024 KGKMRTYWLLGERKGPPGLL 1090 1100 >>XP_024303324 (OMIM: 108961,602875,615923,616255) atria (1103 aa) initn: 5657 init1: 3253 opt: 4592 Z-score: 2059.5 bits: 392.8 E(91609): 6e-108 Smith-Waterman score: 6711; 94.7% identity (94.8% similar) in 1079 aa overlap (1-1023:1-1079) 10 20 30 40 50 60 pF1KE3 MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 PVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 PVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 TAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 TAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 YFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 YFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 QRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 QRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYRE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 PPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTRED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 PPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTRED 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 GLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 GLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWW 370 380 390 400 410 420 430 440 450 460 470 pF1KE3 TGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFR- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 TGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE3 --KLMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 YRKLMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIF 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE3 ANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 ANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTE 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE3 YCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 YCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFV 610 620 630 640 650 660 660 670 680 pF1KE3 LKITDYGLASFRSTAEPDDSHALYA----------------------------------- ::::::::::::::::::::::::: XP_024 LKITDYGLASFRSTAEPDDSHALYASEAHPHNPLFILLLFPPRDGGRGRWSDSNIGMSPG 670 680 690 700 710 720 690 700 710 720 pF1KE3 ------------------KKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPF .::::::::::::::::::::::::::::::::::::::::: XP_024 GLGGAPFRGTWPAGFLFSEKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPF 730 740 750 760 770 780 730 740 750 760 770 780 pF1KE3 YLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 YLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIKG 790 800 810 820 830 840 790 800 810 820 830 840 pF1KE3 FIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 FIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAE 850 860 870 880 890 900 850 860 870 880 890 900 pF1KE3 QLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 QLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYK 910 920 930 940 950 960 910 920 930 940 950 960 pF1KE3 VETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 VETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGP 970 980 990 1000 1010 1020 970 980 990 1000 1010 1020 pF1KE3 VCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 VCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVE 1030 1040 1050 1060 1070 1080 1030 1040 pF1KE3 MKGKGKMRTYWLLGERKGPPGLL XP_024 MKGKGKMRTYWLLGERKGPPGLL 1090 1100 >>NP_000897 (OMIM: 108960) atrial natriuretic peptide re (1061 aa) initn: 3605 init1: 1950 opt: 4181 Z-score: 1878.2 bits: 359.2 E(91609): 7.6e-98 Smith-Waterman score: 4181; 62.0% identity (81.6% similar) in 1048 aa overlap (6-1040:16-1055) 10 20 30 40 50 pF1KE3 MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVA ::::. : .: : :::.::::: : :: :.: :::::: NP_000 MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVE 10 20 30 40 50 60 60 70 80 90 100 pF1KE3 LA---VEALGRALP-VDLRFV--SSELE-GACSEYLAPLSAVDLKLYHDPDLLLGPGCVY :: :.: :: .: : ::: :.::. :::.::::: :.: ..::::::: NP_000 LALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVY 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 PAASVARFASHWRLPLLTAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWT :: :.::..:::.::::::: : ::..: :.: .:.::: :::.::..:: ...: NP_000 AAAPVGRFTAHWRVPLLTAGAPALGFGVK-DEYALTTRAGPSYAKLGDFVAALHRRLGWE 130 140 150 160 170 170 180 190 200 210 pF1KE3 ARAALLYLDARTDDRPH-YFTIEGVFEALQGS-NLSVQHQVYAREPGGPEQATHFIRA-- .: .:: : :. : .: .::.: .. :..:.: .:.. . . :...:. NP_000 RQALMLYA-YRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLS--HYTRLLRTMP 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE3 -NGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNR .::..:::. . .. ..: : . .: . :::::.::.::.::..: : :::. : NP_000 RKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWE--R 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE3 TREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFY : . :.:::.. .:::..: :::: :: ..: : :.:. . .:.: : . :. NP_000 GDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFH 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE3 DGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMG ::.::: ....::. .::: :: :...: .: ..:::: . .:...:::::: :: : NP_000 DGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDM- 360 370 380 390 400 410 400 410 420 430 440 450 pF1KE3 DLDSGDFQPAAHYSGAEKQ-IWWTGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLA : ..: :. . .:.:. .. . .:: . : : :: : : :.:: .::.:.. :::: NP_000 DPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLE 420 430 440 450 460 470 460 470 480 490 500 510 pF1KE3 IVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTL ..:: ..... . . ::.:.::..::::::: :::.:::... .. ::. ..::::::: NP_000 VLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTL 480 490 500 510 520 530 520 530 540 550 560 570 pF1KE3 SLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFN : :::.::::.:..:..:.::.:...:::.::.:.::.:::::::.:::::::::::: . NP_000 SGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNE 540 550 560 570 580 590 580 590 600 610 620 630 pF1KE3 HLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNS :::::.::: :::::::.:::::::::::::::.::.::::::::: ::.:::: ::::. NP_000 HLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNG 600 610 620 630 640 650 640 650 660 670 680 690 pF1KE3 IISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPL : :::.:::::::::.::::::::::: :::. .:...:..:::::::::::: NP_000 AICSHGNLKSSNCVVDGRFVLKITDYGLESFRDL-DPEQGHTVYAKKLWTAPELLRMASP 660 670 680 690 700 710 700 710 720 730 740 750 pF1KE3 PTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQL :. : : .::::::::::::::::: :..::::::::::...: :..: ::::. . NP_000 PVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSH 720 730 740 750 760 770 760 770 780 790 800 810 pF1KE3 NEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVE ::: :::.::::.:: ::: : ::. .:.::.:....:::::: ::::::::::.::: NP_000 LEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVE 780 790 800 810 820 830 820 830 840 850 860 870 pF1KE3 ERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAES 840 850 860 870 880 890 880 890 900 910 920 930 pF1KE3 TPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALAL ::::::::::::::::::.::::::::::::::::::::::: :::. :: :.::::::: NP_000 TPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALAL 900 910 920 930 940 950 940 950 960 970 980 990 pF1KE3 LDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAL :::: ::::::::..:::::::.::::::::::::::::::::::::::::::::::.:: NP_000 LDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEAL 960 970 980 990 1000 1010 1000 1010 1020 1030 1040 pF1KE3 KIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERKGPPGLL :::.:: :: .:.:.: :.::::::::::::::.::::::::: NP_000 KIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG 1020 1030 1040 1050 1060 >>XP_024303329 (OMIM: 108961,602875,615923,616255) atria (579 aa) initn: 3838 init1: 3838 opt: 3838 Z-score: 1729.1 bits: 330.7 E(91609): 1.5e-89 Smith-Waterman score: 3838; 100.0% identity (100.0% similar) in 579 aa overlap (469-1047:1-579) 440 450 460 470 480 490 pF1KE3 CAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEE :::::::::::::::::::::::::::::: XP_024 MFGVSSFLIFRKLMLEKELASMLWRIRWEE 10 20 30 500 510 520 530 540 550 pF1KE3 LQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 LQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRI 40 50 60 70 80 90 560 570 580 590 600 610 pF1KE3 ELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 ELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWM 100 110 120 130 140 150 620 630 640 650 660 670 pF1KE3 FRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 FRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSH 160 170 180 190 200 210 680 690 700 710 720 730 pF1KE3 ALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 ALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQ 220 230 240 250 260 270 740 750 760 770 780 790 pF1KE3 KVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGTSIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 KVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGTSIL 280 290 300 310 320 330 800 810 820 830 840 850 pF1KE3 DNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 DNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFD 340 350 360 370 380 390 860 870 880 890 900 910 pF1KE3 SVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 SVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGL 400 410 420 430 440 450 920 930 940 950 960 970 pF1KE3 PGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 PGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYC 460 470 480 490 500 510 980 990 1000 1010 1020 1030 pF1KE3 LFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 LFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLG 520 530 540 550 560 570 1040 pF1KE3 ERKGPPGLL ::::::::: XP_024 ERKGPPGLL >>XP_005245275 (OMIM: 108960) atrial natriuretic peptide (1035 aa) initn: 3096 init1: 1950 opt: 2520 Z-score: 1144.8 bits: 223.5 E(91609): 5.4e-57 Smith-Waterman score: 3980; 60.0% identity (79.1% similar) in 1048 aa overlap (6-1040:16-1029) 10 20 30 40 50 pF1KE3 MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVA ::::. : .: : :::.::::: : :: :.: :::::: XP_005 MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVE 10 20 30 40 50 60 60 70 80 90 100 pF1KE3 LA---VEALGRALP-VDLRFV--SSELE-GACSEYLAPLSAVDLKLYHDPDLLLGPGCVY :: :.: :: .: : ::: :.::. :::.::::: :.: ..::::::: XP_005 LALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVY 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 PAASVARFASHWRLPLLTAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWT :: :.::..:::.::::::: : ::..: :.: .:.::: :::.::..:: ...: XP_005 AAAPVGRFTAHWRVPLLTAGAPALGFGVK-DEYALTTRAGPSYAKLGDFVAALHRRLGWE 130 140 150 160 170 170 180 190 200 210 pF1KE3 ARAALLYLDARTDDRPH-YFTIEGVFEALQGS-NLSVQHQVYAREPGGPEQATHFIRA-- .: .:: : :. : .: .::.: .. :..:.: .:.. . . :...:. XP_005 RQALMLYA-YRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLS--HYTRLLRTMP 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE3 -NGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNR .::..:::. . .. ..: : . .: . :::::.::.::.::..: : :::. : XP_005 RKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWE--R 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE3 TREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFY : . :.:::.. .:::..: :::: :: ..: : :.:. . .:.: : . :. XP_005 GDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFH 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE3 DGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMG ::.::: ....::. .::: :: :...: .: ..:::: . .:...:::::: :: : XP_005 DGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDM- 360 370 380 390 400 410 400 410 420 430 440 450 pF1KE3 DLDSGDFQPAAHYSGAEKQ-IWWTGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLA : ..: :. . .:.:. .. . .:: . : : :: : : :.:: .::.:.. :::: XP_005 DPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLE 420 430 440 450 460 470 460 470 480 490 500 510 pF1KE3 IVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTL ..:: ..... . . ::.:.::..::::::: :::.:::... .. ::. ..::::::: XP_005 VLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTL 480 490 500 510 520 530 520 530 540 550 560 570 pF1KE3 SLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFN : :::.::::.:..:..:.::.:...: ::::: . XP_005 SGRGSNYGSLLTTEGQFQVFAKTAYYK--------------------------MRDVQNE 540 550 560 580 590 600 610 620 630 pF1KE3 HLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNS :::::.::: :::::::.:::::::::::::::.::.::::::::: ::.:::: ::::. XP_005 HLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNG 570 580 590 600 610 620 640 650 660 670 680 690 pF1KE3 IISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPL : :::.:::::::::.::::::::::: :::. .:...:..:::::::::::: XP_005 AICSHGNLKSSNCVVDGRFVLKITDYGLESFRDL-DPEQGHTVYAKKLWTAPELLRMASP 630 640 650 660 670 680 700 710 720 730 740 750 pF1KE3 PTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQL :. : : .::::::::::::::::: :..::::::::::...: :..: ::::. . XP_005 PVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSH 690 700 710 720 730 740 760 770 780 790 800 810 pF1KE3 NEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVE ::: :::.::::.:: ::: : ::. .:.::.:....:::::: ::::::::::.::: XP_005 LEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVE 750 760 770 780 790 800 820 830 840 850 860 870 pF1KE3 ERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAES 810 820 830 840 850 860 880 890 900 910 920 930 pF1KE3 TPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALAL ::::::::::::::::::.::::::::::::::::::::::: :::. :: :.::::::: XP_005 TPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALAL 870 880 890 900 910 920 940 950 960 970 980 990 pF1KE3 LDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAL :::: ::::::::..:::::::.::::::::::::::::::::::::::::::::::.:: XP_005 LDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEAL 930 940 950 960 970 980 1000 1010 1020 1030 1040 pF1KE3 KIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERKGPPGLL :::.:: :: .:.:.: :.::::::::::::::.::::::::: XP_005 KIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG 990 1000 1010 1020 1030 >>XP_024303328 (OMIM: 108961,602875,615923,616255) atria (632 aa) initn: 2418 init1: 2418 opt: 2427 Z-score: 1105.7 bits: 215.5 E(91609): 8.1e-55 Smith-Waterman score: 3717; 91.5% identity (91.6% similar) in 632 aa overlap (469-1047:1-632) 440 450 460 470 480 490 pF1KE3 CAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEE :::::::::::::::::::::::::::::: XP_024 MFGVSSFLIFRKLMLEKELASMLWRIRWEE 10 20 30 500 510 520 530 540 550 pF1KE3 LQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 LQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRI 40 50 60 70 80 90 560 570 580 590 600 610 pF1KE3 ELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 ELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWM 100 110 120 130 140 150 620 630 640 650 660 670 pF1KE3 FRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 FRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSH 160 170 180 190 200 210 680 pF1KE3 ALYA-----------------------------------------------------KKL :::: .:: XP_024 ALYASEAHPHNPLFILLLFPPRDGGRGRWSDSNIGMSPGGLGGAPFRGTWPAGFLFSEKL 220 230 240 250 260 270 690 700 710 720 730 740 pF1KE3 WTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 WTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQR 280 290 300 310 320 330 750 760 770 780 790 800 pF1KE3 PYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGTSILDNLLLRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 PYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGTSILDNLLLRM 340 350 360 370 380 390 810 820 830 840 850 860 pF1KE3 EQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 EQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFS 400 410 420 430 440 450 870 880 890 900 910 920 pF1KE3 DIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 DIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQR 460 470 480 490 500 510 930 940 950 960 970 980 pF1KE3 HAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 HAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVN 520 530 540 550 560 570 990 1000 1010 1020 1030 1040 pF1KE3 TASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERKGPPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 TASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERKGPPG 580 590 600 610 620 630 pF1KE3 LL :: XP_024 LL >>XP_024303327 (OMIM: 108961,602875,615923,616255) atria (635 aa) initn: 2475 init1: 2418 opt: 2427 Z-score: 1105.7 bits: 215.5 E(91609): 8.1e-55 Smith-Waterman score: 3701; 91.0% identity (91.2% similar) in 635 aa overlap (469-1047:1-635) 440 450 460 470 480 490 pF1KE3 CAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFR---KLMLEKELASMLWRIR ::::::::::: :::::::::::::::: XP_024 MFGVSSFLIFRPYRKLMLEKELASMLWRIR 10 20 30 500 510 520 530 540 550 pF1KE3 WEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 WEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNK 40 50 60 70 80 90 560 570 580 590 600 610 pF1KE3 KRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 KRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINL 100 110 120 130 140 150 620 630 640 650 660 670 pF1KE3 DWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 DWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPD 160 170 180 190 200 210 680 pF1KE3 DSHALYA----------------------------------------------------- ::::::: XP_024 DSHALYASEAHPHNPLFILLLFPPRDGGRGRWSDSNIGMSPGGLGGAPFRGTWPAGFLFS 220 230 240 250 260 270 690 700 710 720 730 740 pF1KE3 KKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVRN .::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 EKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVRN 280 290 300 310 320 330 750 760 770 780 790 800 pF1KE3 GQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGTSILDNLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 GQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGTSILDNLL 340 350 360 370 380 390 810 820 830 840 850 860 pF1KE3 LRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 LRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTI 400 410 420 430 440 450 870 880 890 900 910 920 pF1KE3 YFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 YFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRN 460 470 480 490 500 510 930 940 950 960 970 980 pF1KE3 GQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 GQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGD 520 530 540 550 560 570 990 1000 1010 1020 1030 1040 pF1KE3 TVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 TVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERKG 580 590 600 610 620 630 pF1KE3 PPGLL ::::: XP_024 PPGLL >>XP_024303326 (OMIM: 108961,602875,615923,616255) atria (774 aa) initn: 3450 init1: 2418 opt: 2427 Z-score: 1104.9 bits: 215.6 E(91609): 9e-55 Smith-Waterman score: 4676; 92.6% identity (92.8% similar) in 774 aa overlap (330-1047:1-774) 300 310 320 330 340 350 pF1KE3 EPPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTRE :::::::::::::::::::::::::::::: XP_024 MNLIAGCFYDGILLYAEVLNETIQEGGTRE 10 20 30 360 370 380 390 400 410 pF1KE3 DGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 DGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIW 40 50 60 70 80 90 420 430 440 450 460 470 pF1KE3 WTGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 WTGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFR 100 110 120 130 140 150 480 490 500 510 520 530 pF1KE3 ---KLMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 PYRKLMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQI 160 170 180 190 200 210 540 550 560 570 580 590 pF1KE3 FANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 FANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVT 220 230 240 250 260 270 600 610 620 630 640 650 pF1KE3 EYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 EYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRF 280 290 300 310 320 330 660 670 680 pF1KE3 VLKITDYGLASFRSTAEPDDSHALYA---------------------------------- :::::::::::::::::::::::::: XP_024 VLKITDYGLASFRSTAEPDDSHALYASEAHPHNPLFILLLFPPRDGGRGRWSDSNIGMSP 340 350 360 370 380 390 690 700 710 720 pF1KE3 -------------------KKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGP .:::::::::::::::::::::::::::::::::::::::: XP_024 GGLGGAPFRGTWPAGFLFSEKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGP 400 410 420 430 440 450 730 740 750 760 770 780 pF1KE3 FYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 FYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIK 460 470 480 490 500 510 790 800 810 820 830 840 pF1KE3 GFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 GFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVA 520 530 540 550 560 570 850 860 870 880 890 900 pF1KE3 EQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 EQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVY 580 590 600 610 620 630 910 920 930 940 950 960 pF1KE3 KVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 KVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTG 640 650 660 670 680 690 970 980 990 1000 1010 1020 pF1KE3 PVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 PVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDV 700 710 720 730 740 750 1030 1040 pF1KE3 EMKGKGKMRTYWLLGERKGPPGLL :::::::::::::::::::::::: XP_024 EMKGKGKMRTYWLLGERKGPPGLL 760 770 1047 residues in 1 query sequences 64848753 residues in 91609 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Aug 27 19:45:54 2018 done: Mon Aug 27 19:45:56 2018 Total Scan time: 6.810 Total Display time: 0.280 Function used was FASTA [36.3.4 Apr, 2011]