Result of FASTA (omim) for pF1KE3369
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE3369, 1089 aa
  1>>>pF1KE3369     1089 - 1089 aa - 1089 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 18.2542+/-0.000773; mu= -43.3583+/- 0.046
 mean_var=1145.6569+/-263.413, 0's: 0 Z-trim(111.1): 639  B-trim: 0 in 0/54
 Lambda= 0.037892
 statistics sampled from 19005 (19623) to 19005 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.562), E-opt: 0.2 (0.23), width:  16
 Scan time: 11.530

The best scores are:                                      opt bits E(85289)
XP_005265800 (OMIM: 173490,606764,607685) PREDICTE (1089) 7141 408.9 8.2e-113
XP_011532687 (OMIM: 173490,606764,607685) PREDICTE (1089) 7141 408.9 8.2e-113
NP_006197 (OMIM: 173490,606764,607685) platelet-de (1089) 7141 408.9 8.2e-113
XP_016863769 (OMIM: 173490,606764,607685) PREDICTE (1102) 7141 408.9 8.3e-113
XP_006714102 (OMIM: 173490,606764,607685) PREDICTE (1114) 7141 408.9 8.4e-113
XP_016863771 (OMIM: 173490,606764,607685) PREDICTE ( 807) 5046 294.2   2e-78
XP_016863770 (OMIM: 173490,606764,607685) PREDICTE ( 820) 5046 294.2   2e-78
XP_006714104 (OMIM: 173490,606764,607685) PREDICTE ( 832) 5046 294.2   2e-78
XP_011535961 (OMIM: 131440,173410,213600,228550,60 (1106) 3019 183.6 5.7e-45
NP_002600 (OMIM: 131440,173410,213600,228550,60181 (1106) 3019 183.6 5.7e-45
XP_011535960 (OMIM: 131440,173410,213600,228550,60 (1106) 3019 183.6 5.7e-45
XP_005268521 (OMIM: 131440,173410,213600,228550,60 (1042) 2946 179.6 8.6e-44
XP_016863669 (OMIM: 154800,164920,172800,273300,60 ( 971)  822 63.4 7.4e-09
XP_016863668 (OMIM: 154800,164920,172800,273300,60 ( 972)  822 63.4 7.4e-09
NP_001087241 (OMIM: 154800,164920,172800,273300,60 ( 972)  822 63.4 7.4e-09
XP_005265799 (OMIM: 154800,164920,172800,273300,60 ( 973)  822 63.4 7.4e-09
XP_016863667 (OMIM: 154800,164920,172800,273300,60 ( 975)  822 63.4 7.4e-09
NP_000213 (OMIM: 154800,164920,172800,273300,60676 ( 976)  822 63.4 7.4e-09
XP_005265798 (OMIM: 154800,164920,172800,273300,60 ( 976)  822 63.4 7.4e-09
XP_005265797 (OMIM: 154800,164920,172800,273300,60 ( 977)  822 63.4 7.4e-09
XP_016875978 (OMIM: 136351,613065) PREDICTED: rece ( 694)  765 60.1 5.1e-08
XP_016875977 (OMIM: 136351,613065) PREDICTED: rece ( 700)  765 60.1 5.1e-08
XP_011533320 (OMIM: 136351,613065) PREDICTED: rece ( 818)  765 60.2 5.7e-08
XP_016875976 (OMIM: 136351,613065) PREDICTED: rece ( 818)  765 60.2 5.7e-08
XP_011533319 (OMIM: 136351,613065) PREDICTED: rece ( 818)  765 60.2 5.7e-08
XP_016875974 (OMIM: 165070) PREDICTED: vascular en (1300)  773 60.9 5.8e-08
NP_002010 (OMIM: 165070) vascular endothelial grow (1338)  773 60.9 5.9e-08
XP_016875975 (OMIM: 136351,613065) PREDICTED: rece ( 921)  765 60.3 6.2e-08
XP_011533317 (OMIM: 136351,613065) PREDICTED: rece ( 974)  765 60.3 6.4e-08
NP_004110 (OMIM: 136351,613065) receptor-type tyro ( 993)  765 60.3 6.5e-08
NP_001275634 (OMIM: 164770,221820) macrophage colo ( 972)  756 59.8   9e-08
NP_005202 (OMIM: 164770,221820) macrophage colony- ( 972)  756 59.8   9e-08
XP_011532786 (OMIM: 136352,153100,602089) PREDICTE (1210)  754 59.8 1.1e-07
NP_002011 (OMIM: 136352,153100,602089) vascular en (1298)  754 59.8 1.2e-07
XP_016864757 (OMIM: 136352,153100,602089) PREDICTE (1337)  754 59.8 1.2e-07
NP_891555 (OMIM: 136352,153100,602089) vascular en (1363)  754 59.8 1.2e-07
XP_016864755 (OMIM: 136352,153100,602089) PREDICTE (1375)  754 59.8 1.2e-07
XP_016864756 (OMIM: 136352,153100,602089) PREDICTE (1375)  754 59.8 1.2e-07
XP_016864752 (OMIM: 136352,153100,602089) PREDICTE (1385)  754 59.8 1.2e-07
XP_016864753 (OMIM: 136352,153100,602089) PREDICTE (1385)  754 59.8 1.2e-07
XP_016864754 (OMIM: 136352,153100,602089) PREDICTE (1385)  754 59.8 1.2e-07
XP_011532780 (OMIM: 136352,153100,602089) PREDICTE (1440)  754 59.9 1.3e-07
NP_002244 (OMIM: 191306,602089) vascular endotheli (1356)  750 59.6 1.4e-07
XP_016868719 (OMIM: 101600,123150,136350,147950,16 ( 498)  653 53.9 2.8e-06
XP_016868718 (OMIM: 101600,123150,136350,147950,16 ( 508)  652 53.8   3e-06
XP_016868717 (OMIM: 101600,123150,136350,147950,16 ( 729)  653 54.0 3.7e-06
NP_065681 (OMIM: 142623,155240,162300,164761,17130 (1072)  660 54.6 3.7e-06
NP_075594 (OMIM: 101600,123150,136350,147950,16625 ( 731)  653 54.0 3.7e-06
NP_001167537 (OMIM: 101600,123150,136350,147950,16 ( 733)  653 54.0 3.7e-06
NP_075593 (OMIM: 101600,123150,136350,147950,16625 ( 733)  653 54.0 3.7e-06


>>XP_005265800 (OMIM: 173490,606764,607685) PREDICTED: p  (1089 aa)
 initn: 7141 init1: 7141 opt: 7141  Z-score: 2146.3  bits: 408.9 E(85289): 8.2e-113
Smith-Waterman score: 7141; 100.0% identity (100.0% similar) in 1089 aa overlap (1-1089:1-1089)

               10        20        30        40        50        60
pF1KE3 MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE3 MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE3 VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE3 TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE3 EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE3 EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE3 TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE3 VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE3 RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE3 SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE3 SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE3 LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE3 VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE3 LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE3 RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE3 VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE3 SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE3 PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS
             1030      1040      1050      1060      1070      1080

                
pF1KE3 SDLVEDSFL
       :::::::::
XP_005 SDLVEDSFL
                

>>XP_011532687 (OMIM: 173490,606764,607685) PREDICTED: p  (1089 aa)
 initn: 7141 init1: 7141 opt: 7141  Z-score: 2146.3  bits: 408.9 E(85289): 8.2e-113
Smith-Waterman score: 7141; 100.0% identity (100.0% similar) in 1089 aa overlap (1-1089:1-1089)

               10        20        30        40        50        60
pF1KE3 MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE3 MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE3 VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE3 TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE3 EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE3 EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE3 TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE3 VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE3 RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE3 SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE3 SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE3 LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE3 VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE3 LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE3 RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE3 VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE3 SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE3 PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS
             1030      1040      1050      1060      1070      1080

                
pF1KE3 SDLVEDSFL
       :::::::::
XP_011 SDLVEDSFL
                

>>NP_006197 (OMIM: 173490,606764,607685) platelet-derive  (1089 aa)
 initn: 7141 init1: 7141 opt: 7141  Z-score: 2146.3  bits: 408.9 E(85289): 8.2e-113
Smith-Waterman score: 7141; 100.0% identity (100.0% similar) in 1089 aa overlap (1-1089:1-1089)

               10        20        30        40        50        60
pF1KE3 MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE3 MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE3 VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE3 TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE3 EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE3 EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE3 TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE3 VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE3 RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE3 SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE3 SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE3 LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE3 VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE3 LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE3 RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE3 VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE3 SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE3 PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS
             1030      1040      1050      1060      1070      1080

                
pF1KE3 SDLVEDSFL
       :::::::::
NP_006 SDLVEDSFL
                

>>XP_016863769 (OMIM: 173490,606764,607685) PREDICTED: p  (1102 aa)
 initn: 7141 init1: 7141 opt: 7141  Z-score: 2146.2  bits: 408.9 E(85289): 8.3e-113
Smith-Waterman score: 7141; 100.0% identity (100.0% similar) in 1089 aa overlap (1-1089:14-1102)

                            10        20        30        40       
pF1KE3              MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSL
                    :::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGFAETIRKFPRAMGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSL
               10        20        30        40        50        60

        50        60        70        80        90       100       
pF1KE3 RCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQT
               70        80        90       100       110       120

       110       120       130       140       150       160       
pF1KE3 EENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGV
              130       140       150       160       170       180

       170       180       190       200       210       220       
pF1KE3 VPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKS
              190       200       210       220       230       240

       230       240       250       260       270       280       
pF1KE3 GETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGD
              250       260       270       280       290       300

       290       300       310       320       330       340       
pF1KE3 YECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRI
              310       320       330       340       350       360

       350       360       370       380       390       400       
pF1KE3 SWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTF
              370       380       390       400       410       420

       410       420       430       440       450       460       
pF1KE3 ELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILAN
              430       440       450       460       470       480

       470       480       490       500       510       520       
pF1KE3 NVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTV
              490       500       510       520       530       540

       530       540       550       560       570       580       
pF1KE3 AAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWE
              550       560       570       580       590       600

       590       600       610       620       630       640       
pF1KE3 FPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKI
              610       620       630       640       650       660

       650       660       670       680       690       700       
pF1KE3 MTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDI
              670       680       690       700       710       720

       710       720       730       740       750       760       
pF1KE3 FGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPAS
              730       740       750       760       770       780

       770       780       790       800       810       820       
pF1KE3 YKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLA
              790       800       810       820       830       840

       830       840       850       860       870       880       
pF1KE3 QGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWE
              850       860       870       880       890       900

       890       900       910       920       930       940       
pF1KE3 IFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLS
              910       920       930       940       950       960

       950       960       970       980       990      1000       
pF1KE3 EIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGL
              970       980       990      1000      1010      1020

      1010      1020      1030      1040      1050      1060       
pF1KE3 DEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETI
             1030      1040      1050      1060      1070      1080

      1070      1080         
pF1KE3 EDIDMMDDIGIDSSDLVEDSFL
       ::::::::::::::::::::::
XP_016 EDIDMMDDIGIDSSDLVEDSFL
             1090      1100  

>>XP_006714102 (OMIM: 173490,606764,607685) PREDICTED: p  (1114 aa)
 initn: 7141 init1: 7141 opt: 7141  Z-score: 2146.2  bits: 408.9 E(85289): 8.4e-113
Smith-Waterman score: 7141; 100.0% identity (100.0% similar) in 1089 aa overlap (1-1089:26-1114)

                                        10        20        30     
pF1KE3                          MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNEN
                                :::::::::::::::::::::::::::::::::::
XP_006 MLPRLVLNSWAQMICLPQLPKFPRAMGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNEN
               10        20        30        40        50        60

          40        50        60        70        80        90     
pF1KE3 EKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHT
               70        80        90       100       110       120

         100       110       120       130       140       150     
pF1KE3 GLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDP
              130       140       150       160       170       180

         160       170       180       190       200       210     
pF1KE3 ETPVTLHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ETPVTLHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELD
              190       200       210       220       230       240

         220       230       240       250       260       270     
pF1KE3 LEMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LEMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTL
              250       260       270       280       290       300

         280       290       300       310       320       330     
pF1KE3 TVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHF
              310       320       330       340       350       360

         340       350       360       370       380       390     
pF1KE3 VVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIV
              370       380       390       400       410       420

         400       410       420       430       440       450     
pF1KE3 AQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKK
              430       440       450       460       470       480

         460       470       480       490       500       510     
pF1KE3 CNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELK
              490       500       510       520       530       540

         520       530       540       550       560       570     
pF1KE3 LVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYV
              550       560       570       580       590       600

         580       590       600       610       620       630     
pF1KE3 DPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARS
              610       620       630       640       650       660

         640       650       660       670       680       690     
pF1KE3 SEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLS
              670       680       690       700       710       720

         700       710       720       730       740       750     
pF1KE3 HHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYS
              730       740       750       760       770       780

         760       770       780       790       800       810     
pF1KE3 DIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCV
              790       800       810       820       830       840

         820       830       840       850       860       870     
pF1KE3 HRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTL
              850       860       870       880       890       900

         880       890       900       910       920       930     
pF1KE3 SDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNS
              910       920       930       940       950       960

         940       950       960       970       980       990     
pF1KE3 EPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKN
              970       980       990      1000      1010      1020

        1000      1010      1020      1030      1040      1050     
pF1KE3 EEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSS
             1030      1040      1050      1060      1070      1080

        1060      1070      1080         
pF1KE3 SSTFIKREDETIEDIDMMDDIGIDSSDLVEDSFL
       ::::::::::::::::::::::::::::::::::
XP_006 SSTFIKREDETIEDIDMMDDIGIDSSDLVEDSFL
             1090      1100      1110    

>>XP_016863771 (OMIM: 173490,606764,607685) PREDICTED: p  (807 aa)
 initn: 5046 init1: 5046 opt: 5046  Z-score: 1529.0  bits: 294.2 E(85289): 2e-78
Smith-Waterman score: 5046; 100.0% identity (100.0% similar) in 774 aa overlap (1-774:1-774)

               10        20        30        40        50        60
pF1KE3 MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE3 MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE3 VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE3 TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE3 EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE3 EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE3 TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE3 VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE3 RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE3 SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE3 SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE3 LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE3 VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::      
XP_016 VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLGWAGGV
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE3 LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA
                                                                   
XP_016 GTRCQRNLSHAQAQALLAGRPLLSGLP                                 
              790       800                                        

>>XP_016863770 (OMIM: 173490,606764,607685) PREDICTED: p  (820 aa)
 initn: 5046 init1: 5046 opt: 5046  Z-score: 1528.9  bits: 294.2 E(85289): 2e-78
Smith-Waterman score: 5046; 100.0% identity (100.0% similar) in 774 aa overlap (1-774:14-787)

                            10        20        30        40       
pF1KE3              MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSL
                    :::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGFAETIRKFPRAMGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSL
               10        20        30        40        50        60

        50        60        70        80        90       100       
pF1KE3 RCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQT
               70        80        90       100       110       120

       110       120       130       140       150       160       
pF1KE3 EENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGV
              130       140       150       160       170       180

       170       180       190       200       210       220       
pF1KE3 VPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKS
              190       200       210       220       230       240

       230       240       250       260       270       280       
pF1KE3 GETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGD
              250       260       270       280       290       300

       290       300       310       320       330       340       
pF1KE3 YECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRI
              310       320       330       340       350       360

       350       360       370       380       390       400       
pF1KE3 SWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTF
              370       380       390       400       410       420

       410       420       430       440       450       460       
pF1KE3 ELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILAN
              430       440       450       460       470       480

       470       480       490       500       510       520       
pF1KE3 NVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTV
              490       500       510       520       530       540

       530       540       550       560       570       580       
pF1KE3 AAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWE
              550       560       570       580       590       600

       590       600       610       620       630       640       
pF1KE3 FPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKI
              610       620       630       640       650       660

       650       660       670       680       690       700       
pF1KE3 MTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDI
              670       680       690       700       710       720

       710       720       730       740       750       760       
pF1KE3 FGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPAS
              730       740       750       760       770       780

       770       780       790       800       810       820       
pF1KE3 YKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLA
       :::::::                                                     
XP_016 YKKKSMLGWAGGVGTRCQRNLSHAQAQALLAGRPLLSGLP                    
              790       800       810       820                    

>>XP_006714104 (OMIM: 173490,606764,607685) PREDICTED: p  (832 aa)
 initn: 5046 init1: 5046 opt: 5046  Z-score: 1528.8  bits: 294.2 E(85289): 2e-78
Smith-Waterman score: 5046; 100.0% identity (100.0% similar) in 774 aa overlap (1-774:26-799)

                                        10        20        30     
pF1KE3                          MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNEN
                                :::::::::::::::::::::::::::::::::::
XP_006 MLPRLVLNSWAQMICLPQLPKFPRAMGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNEN
               10        20        30        40        50        60

          40        50        60        70        80        90     
pF1KE3 EKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHT
               70        80        90       100       110       120

         100       110       120       130       140       150     
pF1KE3 GLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDP
              130       140       150       160       170       180

         160       170       180       190       200       210     
pF1KE3 ETPVTLHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ETPVTLHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELD
              190       200       210       220       230       240

         220       230       240       250       260       270     
pF1KE3 LEMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LEMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTL
              250       260       270       280       290       300

         280       290       300       310       320       330     
pF1KE3 TVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHF
              310       320       330       340       350       360

         340       350       360       370       380       390     
pF1KE3 VVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIV
              370       380       390       400       410       420

         400       410       420       430       440       450     
pF1KE3 AQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKK
              430       440       450       460       470       480

         460       470       480       490       500       510     
pF1KE3 CNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELK
              490       500       510       520       530       540

         520       530       540       550       560       570     
pF1KE3 LVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYV
              550       560       570       580       590       600

         580       590       600       610       620       630     
pF1KE3 DPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARS
              610       620       630       640       650       660

         640       650       660       670       680       690     
pF1KE3 SEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLS
              670       680       690       700       710       720

         700       710       720       730       740       750     
pF1KE3 HHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYS
              730       740       750       760       770       780

         760       770       780       790       800       810     
pF1KE3 DIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCV
       :::::::::::::::::::                                         
XP_006 DIQRSLYDRPASYKKKSMLGWAGGVGTRCQRNLSHAQAQALLAGRPLLSGLP        
              790       800       810       820       830          

>>XP_011535961 (OMIM: 131440,173410,213600,228550,601812  (1106 aa)
 initn: 2551 init1: 996 opt: 3019  Z-score: 928.4  bits: 183.6 E(85289): 5.7e-45
Smith-Waterman score: 3019; 45.7% identity (72.5% similar) in 1071 aa overlap (6-1057:8-1059)

                 10        20           30         40        50    
pF1KE3   MGTSHPAFLVLGCLLTGLSLILC---QLSLPSIL-PNENEKVVQLNSSFSLRCFGESE
              ::. . : ::  :::.:    :.:   .. :   : :....:.: : : : . 
XP_011 MRLPGAMPALALKGELLL-LSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAP
               10         20        30        40        50         

           60        70        80        90       100       110    
pF1KE3 VSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEG
       : :.  ::.:  ...     . ..: : .:: ... ..  :: : : .: ..  :.. : 
XP_011 VVWER-MSQEPPQEMA----KAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETD-ER
      60         70            80        90       100       110    

          120       130       140       150       160         170  
pF1KE3 RHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVV--PASY
       ...::.:::: :.:.:    . .... .     ::::.:::.  ::::...: :  :. :
XP_011 KRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPY
           120       130       140       150       160       170   

            180       190       200       210       220       230  
pF1KE3 DSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIV
       : ..::.: :    :::..:.  .. ..  . :: :...: ... ..:..:: ..::.:.
XP_011 DHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSS-INVSVNAVQTVVRQGENIT
           180       190       200       210        220       230  

            240       250       260         270       280       290
pF1KE3 VTCAVFNNEVVDLQWTYPGEVKGKGITMLEE--IKVPSIKLVYTLTVPEATVKDSGDYEC
       . : :..::::...:::: . .:. .  . .  . .:  ..   : .: : ..::: : :
XP_011 LMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMP-YHIRSILHIPSAELEDSGTYTC
            240       250       260        270       280       290 

              300       310       320       330       340       350
pF1KE3 AARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWL
        . ... . .. : ..:.: :.:....    . :. ..::. . . :  .::::: . :.
XP_011 NVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWF
             300       310       320       330       340       350 

              360        370       380       390       400         
pF1KE3 KNNLTLIENLT-EITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFEL
       :.: :: .. . ::. ......: :: :.: :.:.:  ..::::. : .:::  . .:.:
XP_011 KDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQL
             360       370       380       390       400       410 

     410       420       430       440       450       460         
pF1KE3 LTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANN-
         .::  .:.: ..:  : : ::::: ..: : :.: :  :.:.:.:  :   :.:.:. 
XP_011 QINVPVRVLELSESHPDS-GEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSS
             420        430       440       450       460       470

           470       480       490       500       510       520   
pF1KE3 -----VSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRS
            . . .:  . ...  : . . . .:.. ..:::  .: .: ...:. .:  .:  
XP_011 EEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPF
              480       490       500       510       520       530

           530       540       550       560       570       580   
pF1KE3 ELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYD
       ...: .:.:.:.:..:::::.:...:..::::::::.::::.: ::::::::::::::::
XP_011 KVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYD
              540       550       560       570       580       590

           590       600       610       620       630       640   
pF1KE3 SRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMS
       : ::.::: :::::.:::::::.:::.::.:::.:: .::::::::: ::::::::::::
XP_011 STWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMS
              600       610       620       630       640       650

           650       660       670       680       690       700   
pF1KE3 ELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEK---
       :::::.:::::::.:::::::::.:::::::::: :::::.:::.:. .::.:: .:   
XP_011 ELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRP
              660       670       680       690       700       710

              710       720       730       740       750       760
pF1KE3 PKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRS
       :. ::   .: :.     :.: :. :..: ::::.. ....:::::. :   ::.::. :
XP_011 PSAELYSNAL-PVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESS
              720        730       740       750       760         

              770       780       790       800       810       820
pF1KE3 LYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLA
        :  : .    :  .   .  : .. :  :. .::..:.:::: ::::::::::::::::
XP_011 NYMAPYDNYVPSAPERTCRATLINE-SPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLA
     770       780       790        800       810       820        

              830       840       850       860       870       880
pF1KE3 ARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWS
       :::::. .::.:::::::::::::.::::.::::::::.:::::::::..::::::::::
XP_011 ARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWS
      830       840       850       860       870       880        

              890       900       910       920       930       940
pF1KE3 YGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKR
       .::::::::.::::::: . ..  ::: :: :::::.: ::..:.:::: :::. . : :
XP_011 FGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIR
      890       900       910       920       930       940        

              950       960       970       980       990      1000
pF1KE3 PSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKL
       : : .:  ..: ::   :::.:...  .::.:::::. : ..   . . :.  ..  :  
XP_011 PPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPG-FHGL--RSPLDTS
      950       960       970       980       990         1000     

             1010      1020      1030       1040      1050         
pF1KE3 KDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGK-RNRHSSQTSEESAIETGSSSSTF
       .    ... ..  .:. :::::::  : ::  : :  ..  :  .:  . ..:.:. :  
XP_011 SVLYTAVQPNE--GDNDYIIPLPD--PKPEVADEGPLEGSPSLASSTLNEVNTSSTISCD
        1010        1020        1030      1040      1050      1060 

    1060      1070      1080                        
pF1KE3 IKREDETIEDIDMMDDIGIDSSDLVEDSFL               
                                                    
XP_011 SPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL
            1070      1080      1090      1100      

>>NP_002600 (OMIM: 131440,173410,213600,228550,601812,61  (1106 aa)
 initn: 2551 init1: 996 opt: 3019  Z-score: 928.4  bits: 183.6 E(85289): 5.7e-45
Smith-Waterman score: 3019; 45.7% identity (72.5% similar) in 1071 aa overlap (6-1057:8-1059)

                 10        20           30         40        50    
pF1KE3   MGTSHPAFLVLGCLLTGLSLILC---QLSLPSIL-PNENEKVVQLNSSFSLRCFGESE
              ::. . : ::  :::.:    :.:   .. :   : :....:.: : : : . 
NP_002 MRLPGAMPALALKGELLL-LSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAP
               10         20        30        40        50         

           60        70        80        90       100       110    
pF1KE3 VSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEG
       : :.  ::.:  ...     . ..: : .:: ... ..  :: : : .: ..  :.. : 
NP_002 VVWER-MSQEPPQEMA----KAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETD-ER
      60         70            80        90       100       110    

          120       130       140       150       160         170  
pF1KE3 RHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVV--PASY
       ...::.:::: :.:.:    . .... .     ::::.:::.  ::::...: :  :. :
NP_002 KRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPY
           120       130       140       150       160       170   

            180       190       200       210       220       230  
pF1KE3 DSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIV
       : ..::.: :    :::..:.  .. ..  . :: :...: ... ..:..:: ..::.:.
NP_002 DHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSS-INVSVNAVQTVVRQGENIT
           180       190       200       210        220       230  

            240       250       260         270       280       290
pF1KE3 VTCAVFNNEVVDLQWTYPGEVKGKGITMLEE--IKVPSIKLVYTLTVPEATVKDSGDYEC
       . : :..::::...:::: . .:. .  . .  . .:  ..   : .: : ..::: : :
NP_002 LMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMP-YHIRSILHIPSAELEDSGTYTC
            240       250       260        270       280       290 

              300       310       320       330       340       350
pF1KE3 AARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWL
        . ... . .. : ..:.: :.:....    . :. ..::. . . :  .::::: . :.
NP_002 NVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWF
             300       310       320       330       340       350 

              360        370       380       390       400         
pF1KE3 KNNLTLIENLT-EITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFEL
       :.: :: .. . ::. ......: :: :.: :.:.:  ..::::. : .:::  . .:.:
NP_002 KDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQL
             360       370       380       390       400       410 

     410       420       430       440       450       460         
pF1KE3 LTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANN-
         .::  .:.: ..:  : : ::::: ..: : :.: :  :.:.:.:  :   :.:.:. 
NP_002 QINVPVRVLELSESHPDS-GEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSS
             420        430       440       450       460       470

           470       480       490       500       510       520   
pF1KE3 -----VSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRS
            . . .:  . ...  : . . . .:.. ..:::  .: .: ...:. .:  .:  
NP_002 EEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPF
              480       490       500       510       520       530

           530       540       550       560       570       580   
pF1KE3 ELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYD
       ...: .:.:.:.:..:::::.:...:..::::::::.::::.: ::::::::::::::::
NP_002 KVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYD
              540       550       560       570       580       590

           590       600       610       620       630       640   
pF1KE3 SRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMS
       : ::.::: :::::.:::::::.:::.::.:::.:: .::::::::: ::::::::::::
NP_002 STWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMS
              600       610       620       630       640       650

           650       660       670       680       690       700   
pF1KE3 ELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEK---
       :::::.:::::::.:::::::::.:::::::::: :::::.:::.:. .::.:: .:   
NP_002 ELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRP
              660       670       680       690       700       710

              710       720       730       740       750       760
pF1KE3 PKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRS
       :. ::   .: :.     :.: :. :..: ::::.. ....:::::. :   ::.::. :
NP_002 PSAELYSNAL-PVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESS
              720        730       740       750       760         

              770       780       790       800       810       820
pF1KE3 LYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLA
        :  : .    :  .   .  : .. :  :. .::..:.:::: ::::::::::::::::
NP_002 NYMAPYDNYVPSAPERTCRATLINE-SPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLA
     770       780       790        800       810       820        

              830       840       850       860       870       880
pF1KE3 ARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWS
       :::::. .::.:::::::::::::.::::.::::::::.:::::::::..::::::::::
NP_002 ARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWS
      830       840       850       860       870       880        

              890       900       910       920       930       940
pF1KE3 YGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKR
       .::::::::.::::::: . ..  ::: :: :::::.: ::..:.:::: :::. . : :
NP_002 FGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIR
      890       900       910       920       930       940        

              950       960       970       980       990      1000
pF1KE3 PSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKL
       : : .:  ..: ::   :::.:...  .::.:::::. : ..   . . :.  ..  :  
NP_002 PPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPG-FHGL--RSPLDTS
      950       960       970       980       990         1000     

             1010      1020      1030       1040      1050         
pF1KE3 KDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGK-RNRHSSQTSEESAIETGSSSSTF
       .    ... ..  .:. :::::::  : ::  : :  ..  :  .:  . ..:.:. :  
NP_002 SVLYTAVQPNE--GDNDYIIPLPD--PKPEVADEGPLEGSPSLASSTLNEVNTSSTISCD
        1010        1020        1030      1040      1050      1060 

    1060      1070      1080                        
pF1KE3 IKREDETIEDIDMMDDIGIDSSDLVEDSFL               
                                                    
NP_002 SPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL
            1070      1080      1090      1100      




1089 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov 11 17:00:14 2016 done: Fri Nov 11 17:00:15 2016
 Total Scan time: 11.530 Total Display time:  0.490

Function used was FASTA [36.3.4 Apr, 2011]
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