FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3369, 1089 aa 1>>>pF1KE3369 1089 - 1089 aa - 1089 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 18.2542+/-0.000773; mu= -43.3583+/- 0.046 mean_var=1145.6569+/-263.413, 0's: 0 Z-trim(111.1): 639 B-trim: 0 in 0/54 Lambda= 0.037892 statistics sampled from 19005 (19623) to 19005 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.562), E-opt: 0.2 (0.23), width: 16 Scan time: 11.530 The best scores are: opt bits E(85289) XP_005265800 (OMIM: 173490,606764,607685) PREDICTE (1089) 7141 408.9 8.2e-113 XP_011532687 (OMIM: 173490,606764,607685) PREDICTE (1089) 7141 408.9 8.2e-113 NP_006197 (OMIM: 173490,606764,607685) platelet-de (1089) 7141 408.9 8.2e-113 XP_016863769 (OMIM: 173490,606764,607685) PREDICTE (1102) 7141 408.9 8.3e-113 XP_006714102 (OMIM: 173490,606764,607685) PREDICTE (1114) 7141 408.9 8.4e-113 XP_016863771 (OMIM: 173490,606764,607685) PREDICTE ( 807) 5046 294.2 2e-78 XP_016863770 (OMIM: 173490,606764,607685) PREDICTE ( 820) 5046 294.2 2e-78 XP_006714104 (OMIM: 173490,606764,607685) PREDICTE ( 832) 5046 294.2 2e-78 XP_011535961 (OMIM: 131440,173410,213600,228550,60 (1106) 3019 183.6 5.7e-45 NP_002600 (OMIM: 131440,173410,213600,228550,60181 (1106) 3019 183.6 5.7e-45 XP_011535960 (OMIM: 131440,173410,213600,228550,60 (1106) 3019 183.6 5.7e-45 XP_005268521 (OMIM: 131440,173410,213600,228550,60 (1042) 2946 179.6 8.6e-44 XP_016863669 (OMIM: 154800,164920,172800,273300,60 ( 971) 822 63.4 7.4e-09 XP_016863668 (OMIM: 154800,164920,172800,273300,60 ( 972) 822 63.4 7.4e-09 NP_001087241 (OMIM: 154800,164920,172800,273300,60 ( 972) 822 63.4 7.4e-09 XP_005265799 (OMIM: 154800,164920,172800,273300,60 ( 973) 822 63.4 7.4e-09 XP_016863667 (OMIM: 154800,164920,172800,273300,60 ( 975) 822 63.4 7.4e-09 NP_000213 (OMIM: 154800,164920,172800,273300,60676 ( 976) 822 63.4 7.4e-09 XP_005265798 (OMIM: 154800,164920,172800,273300,60 ( 976) 822 63.4 7.4e-09 XP_005265797 (OMIM: 154800,164920,172800,273300,60 ( 977) 822 63.4 7.4e-09 XP_016875978 (OMIM: 136351,613065) PREDICTED: rece ( 694) 765 60.1 5.1e-08 XP_016875977 (OMIM: 136351,613065) PREDICTED: rece ( 700) 765 60.1 5.1e-08 XP_011533320 (OMIM: 136351,613065) PREDICTED: rece ( 818) 765 60.2 5.7e-08 XP_016875976 (OMIM: 136351,613065) PREDICTED: rece ( 818) 765 60.2 5.7e-08 XP_011533319 (OMIM: 136351,613065) PREDICTED: rece ( 818) 765 60.2 5.7e-08 XP_016875974 (OMIM: 165070) PREDICTED: vascular en (1300) 773 60.9 5.8e-08 NP_002010 (OMIM: 165070) vascular endothelial grow (1338) 773 60.9 5.9e-08 XP_016875975 (OMIM: 136351,613065) PREDICTED: rece ( 921) 765 60.3 6.2e-08 XP_011533317 (OMIM: 136351,613065) PREDICTED: rece ( 974) 765 60.3 6.4e-08 NP_004110 (OMIM: 136351,613065) receptor-type tyro ( 993) 765 60.3 6.5e-08 NP_001275634 (OMIM: 164770,221820) macrophage colo ( 972) 756 59.8 9e-08 NP_005202 (OMIM: 164770,221820) macrophage colony- ( 972) 756 59.8 9e-08 XP_011532786 (OMIM: 136352,153100,602089) PREDICTE (1210) 754 59.8 1.1e-07 NP_002011 (OMIM: 136352,153100,602089) vascular en (1298) 754 59.8 1.2e-07 XP_016864757 (OMIM: 136352,153100,602089) PREDICTE (1337) 754 59.8 1.2e-07 NP_891555 (OMIM: 136352,153100,602089) vascular en (1363) 754 59.8 1.2e-07 XP_016864755 (OMIM: 136352,153100,602089) PREDICTE (1375) 754 59.8 1.2e-07 XP_016864756 (OMIM: 136352,153100,602089) PREDICTE (1375) 754 59.8 1.2e-07 XP_016864752 (OMIM: 136352,153100,602089) PREDICTE (1385) 754 59.8 1.2e-07 XP_016864753 (OMIM: 136352,153100,602089) PREDICTE (1385) 754 59.8 1.2e-07 XP_016864754 (OMIM: 136352,153100,602089) PREDICTE (1385) 754 59.8 1.2e-07 XP_011532780 (OMIM: 136352,153100,602089) PREDICTE (1440) 754 59.9 1.3e-07 NP_002244 (OMIM: 191306,602089) vascular endotheli (1356) 750 59.6 1.4e-07 XP_016868719 (OMIM: 101600,123150,136350,147950,16 ( 498) 653 53.9 2.8e-06 XP_016868718 (OMIM: 101600,123150,136350,147950,16 ( 508) 652 53.8 3e-06 XP_016868717 (OMIM: 101600,123150,136350,147950,16 ( 729) 653 54.0 3.7e-06 NP_065681 (OMIM: 142623,155240,162300,164761,17130 (1072) 660 54.6 3.7e-06 NP_075594 (OMIM: 101600,123150,136350,147950,16625 ( 731) 653 54.0 3.7e-06 NP_001167537 (OMIM: 101600,123150,136350,147950,16 ( 733) 653 54.0 3.7e-06 NP_075593 (OMIM: 101600,123150,136350,147950,16625 ( 733) 653 54.0 3.7e-06 >>XP_005265800 (OMIM: 173490,606764,607685) PREDICTED: p (1089 aa) initn: 7141 init1: 7141 opt: 7141 Z-score: 2146.3 bits: 408.9 E(85289): 8.2e-113 Smith-Waterman score: 7141; 100.0% identity (100.0% similar) in 1089 aa overlap (1-1089:1-1089) 10 20 30 40 50 60 pF1KE3 MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE3 VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE3 SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE3 PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS 1030 1040 1050 1060 1070 1080 pF1KE3 SDLVEDSFL ::::::::: XP_005 SDLVEDSFL >>XP_011532687 (OMIM: 173490,606764,607685) PREDICTED: p (1089 aa) initn: 7141 init1: 7141 opt: 7141 Z-score: 2146.3 bits: 408.9 E(85289): 8.2e-113 Smith-Waterman score: 7141; 100.0% identity (100.0% similar) in 1089 aa overlap (1-1089:1-1089) 10 20 30 40 50 60 pF1KE3 MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE3 VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE3 SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE3 PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS 1030 1040 1050 1060 1070 1080 pF1KE3 SDLVEDSFL ::::::::: XP_011 SDLVEDSFL >>NP_006197 (OMIM: 173490,606764,607685) platelet-derive (1089 aa) initn: 7141 init1: 7141 opt: 7141 Z-score: 2146.3 bits: 408.9 E(85289): 8.2e-113 Smith-Waterman score: 7141; 100.0% identity (100.0% similar) in 1089 aa overlap (1-1089:1-1089) 10 20 30 40 50 60 pF1KE3 MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE3 VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE3 SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE3 PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS 1030 1040 1050 1060 1070 1080 pF1KE3 SDLVEDSFL ::::::::: NP_006 SDLVEDSFL >>XP_016863769 (OMIM: 173490,606764,607685) PREDICTED: p (1102 aa) initn: 7141 init1: 7141 opt: 7141 Z-score: 2146.2 bits: 408.9 E(85289): 8.3e-113 Smith-Waterman score: 7141; 100.0% identity (100.0% similar) in 1089 aa overlap (1-1089:14-1102) 10 20 30 40 pF1KE3 MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSL ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGFAETIRKFPRAMGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 RCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQT 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 EENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGV 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE3 VPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKS 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE3 GETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGD 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE3 YECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRI 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE3 SWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTF 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE3 ELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILAN 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE3 NVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTV 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE3 AAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWE 550 560 570 580 590 600 590 600 610 620 630 640 pF1KE3 FPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKI 610 620 630 640 650 660 650 660 670 680 690 700 pF1KE3 MTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDI 670 680 690 700 710 720 710 720 730 740 750 760 pF1KE3 FGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPAS 730 740 750 760 770 780 770 780 790 800 810 820 pF1KE3 YKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLA 790 800 810 820 830 840 830 840 850 860 870 880 pF1KE3 QGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWE 850 860 870 880 890 900 890 900 910 920 930 940 pF1KE3 IFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLS 910 920 930 940 950 960 950 960 970 980 990 1000 pF1KE3 EIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGL 970 980 990 1000 1010 1020 1010 1020 1030 1040 1050 1060 pF1KE3 DEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETI 1030 1040 1050 1060 1070 1080 1070 1080 pF1KE3 EDIDMMDDIGIDSSDLVEDSFL :::::::::::::::::::::: XP_016 EDIDMMDDIGIDSSDLVEDSFL 1090 1100 >>XP_006714102 (OMIM: 173490,606764,607685) PREDICTED: p (1114 aa) initn: 7141 init1: 7141 opt: 7141 Z-score: 2146.2 bits: 408.9 E(85289): 8.4e-113 Smith-Waterman score: 7141; 100.0% identity (100.0% similar) in 1089 aa overlap (1-1089:26-1114) 10 20 30 pF1KE3 MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNEN ::::::::::::::::::::::::::::::::::: XP_006 MLPRLVLNSWAQMICLPQLPKFPRAMGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNEN 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE3 EKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHT 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE3 GLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDP 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE3 ETPVTLHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ETPVTLHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELD 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE3 LEMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LEMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTL 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE3 TVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHF 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE3 VVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIV 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE3 AQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKK 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE3 CNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELK 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE3 LVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYV 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE3 DPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARS 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE3 SEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLS 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE3 HHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYS 730 740 750 760 770 780 760 770 780 790 800 810 pF1KE3 DIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCV 790 800 810 820 830 840 820 830 840 850 860 870 pF1KE3 HRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTL 850 860 870 880 890 900 880 890 900 910 920 930 pF1KE3 SDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNS 910 920 930 940 950 960 940 950 960 970 980 990 pF1KE3 EPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKN 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KE3 EEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSS 1030 1040 1050 1060 1070 1080 1060 1070 1080 pF1KE3 SSTFIKREDETIEDIDMMDDIGIDSSDLVEDSFL :::::::::::::::::::::::::::::::::: XP_006 SSTFIKREDETIEDIDMMDDIGIDSSDLVEDSFL 1090 1100 1110 >>XP_016863771 (OMIM: 173490,606764,607685) PREDICTED: p (807 aa) initn: 5046 init1: 5046 opt: 5046 Z-score: 1529.0 bits: 294.2 E(85289): 2e-78 Smith-Waterman score: 5046; 100.0% identity (100.0% similar) in 774 aa overlap (1-774:1-774) 10 20 30 40 50 60 pF1KE3 MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLGWAGGV 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA XP_016 GTRCQRNLSHAQAQALLAGRPLLSGLP 790 800 >>XP_016863770 (OMIM: 173490,606764,607685) PREDICTED: p (820 aa) initn: 5046 init1: 5046 opt: 5046 Z-score: 1528.9 bits: 294.2 E(85289): 2e-78 Smith-Waterman score: 5046; 100.0% identity (100.0% similar) in 774 aa overlap (1-774:14-787) 10 20 30 40 pF1KE3 MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSL ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGFAETIRKFPRAMGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 RCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQT 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 EENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGV 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE3 VPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKS 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE3 GETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGD 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE3 YECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRI 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE3 SWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTF 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE3 ELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILAN 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE3 NVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTV 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE3 AAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWE 550 560 570 580 590 600 590 600 610 620 630 640 pF1KE3 FPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKI 610 620 630 640 650 660 650 660 670 680 690 700 pF1KE3 MTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDI 670 680 690 700 710 720 710 720 730 740 750 760 pF1KE3 FGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPAS 730 740 750 760 770 780 770 780 790 800 810 820 pF1KE3 YKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLA ::::::: XP_016 YKKKSMLGWAGGVGTRCQRNLSHAQAQALLAGRPLLSGLP 790 800 810 820 >>XP_006714104 (OMIM: 173490,606764,607685) PREDICTED: p (832 aa) initn: 5046 init1: 5046 opt: 5046 Z-score: 1528.8 bits: 294.2 E(85289): 2e-78 Smith-Waterman score: 5046; 100.0% identity (100.0% similar) in 774 aa overlap (1-774:26-799) 10 20 30 pF1KE3 MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNEN ::::::::::::::::::::::::::::::::::: XP_006 MLPRLVLNSWAQMICLPQLPKFPRAMGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNEN 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE3 EKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHT 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE3 GLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDP 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE3 ETPVTLHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ETPVTLHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELD 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE3 LEMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LEMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTL 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE3 TVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHF 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE3 VVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIV 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE3 AQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKK 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE3 CNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELK 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE3 LVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYV 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE3 DPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARS 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE3 SEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLS 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE3 HHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYS 730 740 750 760 770 780 760 770 780 790 800 810 pF1KE3 DIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCV ::::::::::::::::::: XP_006 DIQRSLYDRPASYKKKSMLGWAGGVGTRCQRNLSHAQAQALLAGRPLLSGLP 790 800 810 820 830 >>XP_011535961 (OMIM: 131440,173410,213600,228550,601812 (1106 aa) initn: 2551 init1: 996 opt: 3019 Z-score: 928.4 bits: 183.6 E(85289): 5.7e-45 Smith-Waterman score: 3019; 45.7% identity (72.5% similar) in 1071 aa overlap (6-1057:8-1059) 10 20 30 40 50 pF1KE3 MGTSHPAFLVLGCLLTGLSLILC---QLSLPSIL-PNENEKVVQLNSSFSLRCFGESE ::. . : :: :::.: :.: .. : : :....:.: : : : . XP_011 MRLPGAMPALALKGELLL-LSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAP 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 VSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEG : :. ::.: ... . ..: : .:: ... .. :: : : .: .. :.. : XP_011 VVWER-MSQEPPQEMA----KAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETD-ER 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 RHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVV--PASY ...::.:::: :.:.: . .... . ::::.:::. ::::...: : :. : XP_011 KRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPY 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 DSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIV : ..::.: : :::..:. .. .. . :: :...: ... ..:..:: ..::.:. XP_011 DHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSS-INVSVNAVQTVVRQGENIT 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 VTCAVFNNEVVDLQWTYPGEVKGKGITMLEE--IKVPSIKLVYTLTVPEATVKDSGDYEC . : :..::::...:::: . .:. . . . . .: .. : .: : ..::: : : XP_011 LMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMP-YHIRSILHIPSAELEDSGTYTC 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 AARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWL . ... . .. : ..:.: :.:.... . :. ..::. . . : .::::: . :. XP_011 NVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWF 300 310 320 330 340 350 360 370 380 390 400 pF1KE3 KNNLTLIENLT-EITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFEL :.: :: .. . ::. ......: :: :.: :.:.: ..::::. : .::: . .:.: XP_011 KDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQL 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE3 LTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANN- .:: .:.: ..: : : ::::: ..: : :.: : :.:.:.: : :.:.:. XP_011 QINVPVRVLELSESHPDS-GEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSS 420 430 440 450 460 470 470 480 490 500 510 520 pF1KE3 -----VSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRS . . .: . ... : . . . .:.. ..::: .: .: ...:. .: .: XP_011 EEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPF 480 490 500 510 520 530 530 540 550 560 570 580 pF1KE3 ELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYD ...: .:.:.:.:..:::::.:...:..::::::::.::::.: :::::::::::::::: XP_011 KVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYD 540 550 560 570 580 590 590 600 610 620 630 640 pF1KE3 SRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMS : ::.::: :::::.:::::::.:::.::.:::.:: .::::::::: :::::::::::: XP_011 STWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMS 600 610 620 630 640 650 650 660 670 680 690 700 pF1KE3 ELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEK--- :::::.:::::::.:::::::::.:::::::::: :::::.:::.:. .::.:: .: XP_011 ELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRP 660 670 680 690 700 710 710 720 730 740 750 760 pF1KE3 PKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRS :. :: .: :. :.: :. :..: ::::.. ....:::::. : ::.::. : XP_011 PSAELYSNAL-PVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESS 720 730 740 750 760 770 780 790 800 810 820 pF1KE3 LYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLA : : . : . . : .. : :. .::..:.:::: :::::::::::::::: XP_011 NYMAPYDNYVPSAPERTCRATLINE-SPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLA 770 780 790 800 810 820 830 840 850 860 870 880 pF1KE3 ARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWS :::::. .::.:::::::::::::.::::.::::::::.:::::::::..:::::::::: XP_011 ARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWS 830 840 850 860 870 880 890 900 910 920 930 940 pF1KE3 YGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKR .::::::::.::::::: . .. ::: :: :::::.: ::..:.:::: :::. . : : XP_011 FGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIR 890 900 910 920 930 940 950 960 970 980 990 1000 pF1KE3 PSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKL : : .: ..: :: :::.:... .::.:::::. : .. . . :. .. : XP_011 PPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPG-FHGL--RSPLDTS 950 960 970 980 990 1000 1010 1020 1030 1040 1050 pF1KE3 KDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGK-RNRHSSQTSEESAIETGSSSSTF . ... .. .:. ::::::: : :: : : .. : .: . ..:.:. : XP_011 SVLYTAVQPNE--GDNDYIIPLPD--PKPEVADEGPLEGSPSLASSTLNEVNTSSTISCD 1010 1020 1030 1040 1050 1060 1060 1070 1080 pF1KE3 IKREDETIEDIDMMDDIGIDSSDLVEDSFL XP_011 SPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 1070 1080 1090 1100 >>NP_002600 (OMIM: 131440,173410,213600,228550,601812,61 (1106 aa) initn: 2551 init1: 996 opt: 3019 Z-score: 928.4 bits: 183.6 E(85289): 5.7e-45 Smith-Waterman score: 3019; 45.7% identity (72.5% similar) in 1071 aa overlap (6-1057:8-1059) 10 20 30 40 50 pF1KE3 MGTSHPAFLVLGCLLTGLSLILC---QLSLPSIL-PNENEKVVQLNSSFSLRCFGESE ::. . : :: :::.: :.: .. : : :....:.: : : : . NP_002 MRLPGAMPALALKGELLL-LSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAP 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 VSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEG : :. ::.: ... . ..: : .:: ... .. :: : : .: .. :.. : NP_002 VVWER-MSQEPPQEMA----KAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETD-ER 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 RHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVV--PASY ...::.:::: :.:.: . .... . ::::.:::. ::::...: : :. : NP_002 KRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPY 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 DSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIV : ..::.: : :::..:. .. .. . :: :...: ... ..:..:: ..::.:. NP_002 DHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSS-INVSVNAVQTVVRQGENIT 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 VTCAVFNNEVVDLQWTYPGEVKGKGITMLEE--IKVPSIKLVYTLTVPEATVKDSGDYEC . : :..::::...:::: . .:. . . . . .: .. : .: : ..::: : : NP_002 LMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMP-YHIRSILHIPSAELEDSGTYTC 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 AARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWL . ... . .. : ..:.: :.:.... . :. ..::. . . : .::::: . :. NP_002 NVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWF 300 310 320 330 340 350 360 370 380 390 400 pF1KE3 KNNLTLIENLT-EITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFEL :.: :: .. . ::. ......: :: :.: :.:.: ..::::. : .::: . .:.: NP_002 KDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQL 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE3 LTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANN- .:: .:.: ..: : : ::::: ..: : :.: : :.:.:.: : :.:.:. NP_002 QINVPVRVLELSESHPDS-GEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSS 420 430 440 450 460 470 470 480 490 500 510 520 pF1KE3 -----VSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRS . . .: . ... : . . . .:.. ..::: .: .: ...:. .: .: NP_002 EEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPF 480 490 500 510 520 530 530 540 550 560 570 580 pF1KE3 ELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYD ...: .:.:.:.:..:::::.:...:..::::::::.::::.: :::::::::::::::: NP_002 KVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYD 540 550 560 570 580 590 590 600 610 620 630 640 pF1KE3 SRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMS : ::.::: :::::.:::::::.:::.::.:::.:: .::::::::: :::::::::::: NP_002 STWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMS 600 610 620 630 640 650 650 660 670 680 690 700 pF1KE3 ELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEK--- :::::.:::::::.:::::::::.:::::::::: :::::.:::.:. .::.:: .: NP_002 ELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRP 660 670 680 690 700 710 710 720 730 740 750 760 pF1KE3 PKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRS :. :: .: :. :.: :. :..: ::::.. ....:::::. : ::.::. : NP_002 PSAELYSNAL-PVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESS 720 730 740 750 760 770 780 790 800 810 820 pF1KE3 LYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLA : : . : . . : .. : :. .::..:.:::: :::::::::::::::: NP_002 NYMAPYDNYVPSAPERTCRATLINE-SPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLA 770 780 790 800 810 820 830 840 850 860 870 880 pF1KE3 ARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWS :::::. .::.:::::::::::::.::::.::::::::.:::::::::..:::::::::: NP_002 ARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWS 830 840 850 860 870 880 890 900 910 920 930 940 pF1KE3 YGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKR .::::::::.::::::: . .. ::: :: :::::.: ::..:.:::: :::. . : : NP_002 FGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIR 890 900 910 920 930 940 950 960 970 980 990 1000 pF1KE3 PSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKL : : .: ..: :: :::.:... .::.:::::. : .. . . :. .. : NP_002 PPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPG-FHGL--RSPLDTS 950 960 970 980 990 1000 1010 1020 1030 1040 1050 pF1KE3 KDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGK-RNRHSSQTSEESAIETGSSSSTF . ... .. .:. ::::::: : :: : : .. : .: . ..:.:. : NP_002 SVLYTAVQPNE--GDNDYIIPLPD--PKPEVADEGPLEGSPSLASSTLNEVNTSSTISCD 1010 1020 1030 1040 1050 1060 1060 1070 1080 pF1KE3 IKREDETIEDIDMMDDIGIDSSDLVEDSFL NP_002 SPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL 1070 1080 1090 1100 1089 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 11 17:00:14 2016 done: Fri Nov 11 17:00:15 2016 Total Scan time: 11.530 Total Display time: 0.490 Function used was FASTA [36.3.4 Apr, 2011]