FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3523, 349 aa 1>>>pF1KE3523 349 - 349 aa - 349 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.8524+/-0.00127; mu= 3.2889+/- 0.073 mean_var=253.6694+/-60.367, 0's: 0 Z-trim(108.3): 639 B-trim: 111 in 1/48 Lambda= 0.080527 statistics sampled from 9321 (10096) to 9321 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.678), E-opt: 0.2 (0.31), width: 16 Scan time: 2.610 The best scores are: opt bits E(32554) CCDS2350.1 CDK15 gene_id:65061|Hs108|chr2 ( 384) 2365 288.5 6.2e-78 CCDS58746.1 CDK15 gene_id:65061|Hs108|chr2 ( 400) 2365 288.5 6.4e-78 CCDS58747.1 CDK15 gene_id:65061|Hs108|chr2 ( 429) 2359 287.9 1.1e-77 CCDS75627.1 CDK14 gene_id:5218|Hs108|chr7 ( 423) 1473 184.9 1e-46 CCDS5619.1 CDK14 gene_id:5218|Hs108|chr7 ( 451) 1473 185.0 1.1e-46 CCDS75626.1 CDK14 gene_id:5218|Hs108|chr7 ( 469) 1473 185.0 1.1e-46 CCDS75628.1 CDK14 gene_id:5218|Hs108|chr7 ( 340) 1352 170.7 1.5e-42 CCDS14276.1 CDK16 gene_id:5127|Hs108|chrX ( 496) 1141 146.4 4.7e-35 CCDS48101.1 CDK16 gene_id:5127|Hs108|chrX ( 502) 1141 146.4 4.7e-35 CCDS55408.1 CDK16 gene_id:5127|Hs108|chrX ( 570) 1141 146.5 5.1e-35 CCDS44300.1 CDK18 gene_id:5129|Hs108|chr1 ( 474) 1122 144.2 2.1e-34 CCDS1454.1 CDK18 gene_id:5129|Hs108|chr1 ( 504) 1122 144.2 2.2e-34 CCDS9061.1 CDK17 gene_id:5128|Hs108|chr12 ( 523) 1122 144.3 2.2e-34 CCDS53819.1 CDK17 gene_id:5128|Hs108|chr12 ( 523) 1122 144.3 2.2e-34 CCDS47748.1 CDK5 gene_id:1020|Hs108|chr7 ( 292) 974 126.8 2.3e-29 CCDS11736.1 CDK3 gene_id:1018|Hs108|chr17 ( 305) 963 125.5 5.8e-29 CCDS8898.1 CDK2 gene_id:1017|Hs108|chr12 ( 298) 890 117.0 2e-26 CCDS44408.1 CDK1 gene_id:983|Hs108|chr10 ( 297) 837 110.8 1.4e-24 CCDS3999.1 CDK7 gene_id:1022|Hs108|chr5 ( 346) 727 98.1 1.1e-20 CCDS72682.1 CDK11B gene_id:984|Hs108|chr1 ( 748) 727 98.6 1.8e-20 CCDS72684.1 CDK11B gene_id:984|Hs108|chr1 ( 782) 727 98.6 1.9e-20 CCDS72683.1 CDK11B gene_id:984|Hs108|chr1 ( 795) 727 98.6 1.9e-20 CCDS44043.1 CDK11A gene_id:728642|Hs108|chr1 ( 770) 719 97.6 3.5e-20 CCDS81254.1 CDK11A gene_id:728642|Hs108|chr1 ( 779) 719 97.6 3.6e-20 CCDS44042.1 CDK11A gene_id:728642|Hs108|chr1 ( 780) 719 97.6 3.6e-20 CCDS81253.1 CDK11A gene_id:728642|Hs108|chr1 ( 783) 719 97.7 3.6e-20 CCDS35060.1 CDK20 gene_id:23552|Hs108|chr9 ( 346) 684 93.2 3.6e-19 CCDS10984.2 CDK10 gene_id:8558|Hs108|chr16 ( 360) 661 90.5 2.3e-18 CCDS4949.1 ICK gene_id:22858|Hs108|chr6 ( 632) 638 88.1 2.1e-17 CCDS75398.1 MAK gene_id:4117|Hs108|chr6 ( 583) 637 88.0 2.2e-17 CCDS4516.1 MAK gene_id:4117|Hs108|chr6 ( 623) 637 88.0 2.3e-17 CCDS75399.1 MAK gene_id:4117|Hs108|chr6 ( 648) 637 88.0 2.3e-17 CCDS3570.1 CDKL2 gene_id:8999|Hs108|chr4 ( 493) 610 84.7 1.7e-16 CCDS82933.1 CDKL2 gene_id:8999|Hs108|chr4 ( 570) 610 84.8 1.9e-16 CCDS47265.1 CDKL3 gene_id:51265|Hs108|chr5 ( 455) 604 84.0 2.7e-16 CCDS47264.1 CDKL3 gene_id:51265|Hs108|chr5 ( 592) 604 84.1 3.1e-16 CCDS13795.1 MAPK1 gene_id:5594|Hs108|chr22 ( 360) 597 83.1 4e-16 CCDS33184.1 CDKL4 gene_id:344387|Hs108|chr2 ( 315) 593 82.5 5.1e-16 CCDS32514.2 CDK10 gene_id:8558|Hs108|chr16 ( 272) 590 82.1 5.9e-16 CCDS42149.1 MAPK3 gene_id:5595|Hs108|chr16 ( 357) 581 81.2 1.5e-15 CCDS10672.1 MAPK3 gene_id:5595|Hs108|chr16 ( 379) 581 81.2 1.5e-15 CCDS5628.1 CDK6 gene_id:1021|Hs108|chr7 ( 326) 576 80.6 2.1e-15 CCDS6879.1 CDK9 gene_id:1025|Hs108|chr9 ( 372) 576 80.6 2.2e-15 CCDS83458.1 CDKL5 gene_id:6792|Hs108|chrX ( 960) 577 81.3 3.8e-15 CCDS14186.1 CDKL5 gene_id:6792|Hs108|chrX (1030) 577 81.3 3.9e-15 CCDS11206.1 MAPK7 gene_id:5598|Hs108|chr17 ( 816) 575 80.9 4e-15 CCDS9699.1 CDKL1 gene_id:8814|Hs108|chr14 ( 358) 567 79.6 4.5e-15 CCDS8953.1 CDK4 gene_id:1019|Hs108|chr12 ( 303) 559 78.6 7.7e-15 CCDS8899.1 CDK2 gene_id:1017|Hs108|chr12 ( 264) 541 76.4 3e-14 CCDS73637.1 CDKL1 gene_id:8814|Hs108|chr14 ( 276) 541 76.4 3.1e-14 >>CCDS2350.1 CDK15 gene_id:65061|Hs108|chr2 (384 aa) initn: 2365 init1: 2365 opt: 2365 Z-score: 1512.6 bits: 288.5 E(32554): 6.2e-78 Smith-Waterman score: 2365; 100.0% identity (100.0% similar) in 349 aa overlap (1-349:1-349) 10 20 30 40 50 60 pF1KE3 MTSFHPRGLQAARAQKFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS23 MTSFHPRGLQAARAQKFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS23 GSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 ETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS23 ETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 ISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS23 ISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 EMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS23 EMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVW 250 260 270 280 290 300 310 320 330 340 pF1KE3 NRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDE ::::::::::::::::::::::::::::::::::::::::::::::::: CCDS23 NRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDEESLFTVSGVRL 310 320 330 340 350 360 CCDS23 KPEMCDLLASYQKGHHPAQFSKCW 370 380 >>CCDS58746.1 CDK15 gene_id:65061|Hs108|chr2 (400 aa) initn: 2365 init1: 2365 opt: 2365 Z-score: 1512.4 bits: 288.5 E(32554): 6.4e-78 Smith-Waterman score: 2365; 100.0% identity (100.0% similar) in 349 aa overlap (1-349:52-400) 10 20 30 pF1KE3 MTSFHPRGLQAARAQKFKSKRPRSNSDCFQ :::::::::::::::::::::::::::::: CCDS58 GGEAHSCRRSQPETTEAAFKLTDLKEASCSMTSFHPRGLQAARAQKFKSKRPRSNSDCFQ 30 40 50 60 70 80 40 50 60 70 80 90 pF1KE3 EEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 EEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEG 90 100 110 120 130 140 100 110 120 130 140 150 pF1KE3 VPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 VPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNV 150 160 170 180 190 200 160 170 180 190 200 210 pF1KE3 RLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 RLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVV 210 220 230 240 250 260 220 230 240 250 260 270 pF1KE3 TLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 TLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPT 270 280 290 300 310 320 280 290 300 310 320 330 pF1KE3 EDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 EDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEA 330 340 350 360 370 380 340 pF1KE3 LVHDYFSALPSQLYQLPDE ::::::::::::::::::: CCDS58 LVHDYFSALPSQLYQLPDE 390 400 >>CCDS58747.1 CDK15 gene_id:65061|Hs108|chr2 (429 aa) initn: 2359 init1: 2359 opt: 2359 Z-score: 1508.3 bits: 287.9 E(32554): 1.1e-77 Smith-Waterman score: 2359; 100.0% identity (100.0% similar) in 348 aa overlap (1-348:52-399) 10 20 30 pF1KE3 MTSFHPRGLQAARAQKFKSKRPRSNSDCFQ :::::::::::::::::::::::::::::: CCDS58 GGEAHSCRRSQPETTEAAFKLTDLKEASCSMTSFHPRGLQAARAQKFKSKRPRSNSDCFQ 30 40 50 60 70 80 40 50 60 70 80 90 pF1KE3 EEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 EEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEG 90 100 110 120 130 140 100 110 120 130 140 150 pF1KE3 VPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 VPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNV 150 160 170 180 190 200 160 170 180 190 200 210 pF1KE3 RLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 RLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVV 210 220 230 240 250 260 220 230 240 250 260 270 pF1KE3 TLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 TLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPT 270 280 290 300 310 320 280 290 300 310 320 330 pF1KE3 EDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 EDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEA 330 340 350 360 370 380 340 pF1KE3 LVHDYFSALPSQLYQLPDE :::::::::::::::::: CCDS58 LVHDYFSALPSQLYQLPDVSGVRLKPEMCDLLASYQKGHHPAQFSKCW 390 400 410 420 >>CCDS75627.1 CDK14 gene_id:5218|Hs108|chr7 (423 aa) initn: 1473 init1: 1473 opt: 1473 Z-score: 952.1 bits: 184.9 E(32554): 1e-46 Smith-Waterman score: 1473; 70.6% identity (90.1% similar) in 303 aa overlap (46-348:83-385) 20 30 40 50 60 70 pF1KE3 KFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKGISRING :: :.:: .::::::::::::::: :..:: CCDS75 ACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNG 60 70 80 90 100 110 80 90 100 110 120 130 pF1KE3 QLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLA .::::::: .. :::.:::::::::::::::::::::::::::::::::.::::.:::: CCDS75 KLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLC 120 130 140 150 160 170 140 150 160 170 180 190 pF1KE3 QYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLA :::..::::::: ::.::.:::::::.:::....::::::::::::: ::::::::::: CCDS75 QYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLA 180 190 200 210 220 230 200 210 220 230 240 250 pF1KE3 RAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNI ::::.::.:::.:::::::::::.:::.::::. ::.::.::::.::.:: :::...: CCDS75 RAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDI 240 250 260 270 280 290 260 270 280 290 300 310 pF1KE3 LEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQ .:::.:. :::.:.::::::: .::...:: : : . ..:. .::.:. : .::::::. CCDS75 QDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASK 300 310 320 330 340 350 320 330 340 pF1KE3 MLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDE .:. :..:.::: :: :.::: :: .:..: : CCDS75 LLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFGKNN 360 370 380 390 400 410 CCDS75 SYGKSLSNSKH 420 >>CCDS5619.1 CDK14 gene_id:5218|Hs108|chr7 (451 aa) initn: 1473 init1: 1473 opt: 1473 Z-score: 951.8 bits: 185.0 E(32554): 1.1e-46 Smith-Waterman score: 1473; 70.6% identity (90.1% similar) in 303 aa overlap (46-348:111-413) 20 30 40 50 60 70 pF1KE3 KFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKGISRING :: :.:: .::::::::::::::: :..:: CCDS56 ACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNG 90 100 110 120 130 140 80 90 100 110 120 130 pF1KE3 QLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLA .::::::: .. :::.:::::::::::::::::::::::::::::::::.::::.:::: CCDS56 KLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLC 150 160 170 180 190 200 140 150 160 170 180 190 pF1KE3 QYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLA :::..::::::: ::.::.:::::::.:::....::::::::::::: ::::::::::: CCDS56 QYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLA 210 220 230 240 250 260 200 210 220 230 240 250 pF1KE3 RAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNI ::::.::.:::.:::::::::::.:::.::::. ::.::.::::.::.:: :::...: CCDS56 RAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDI 270 280 290 300 310 320 260 270 280 290 300 310 pF1KE3 LEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQ .:::.:. :::.:.::::::: .::...:: : : . ..:. .::.:. : .::::::. CCDS56 QDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASK 330 340 350 360 370 380 320 330 340 pF1KE3 MLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDE .:. :..:.::: :: :.::: :: .:..: : CCDS56 LLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFGKNN 390 400 410 420 430 440 CCDS56 SYGKSLSNSKH 450 >>CCDS75626.1 CDK14 gene_id:5218|Hs108|chr7 (469 aa) initn: 1473 init1: 1473 opt: 1473 Z-score: 951.6 bits: 185.0 E(32554): 1.1e-46 Smith-Waterman score: 1473; 70.6% identity (90.1% similar) in 303 aa overlap (46-348:129-431) 20 30 40 50 60 70 pF1KE3 KFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKGISRING :: :.:: .::::::::::::::: :..:: CCDS75 ACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNG 100 110 120 130 140 150 80 90 100 110 120 130 pF1KE3 QLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLA .::::::: .. :::.:::::::::::::::::::::::::::::::::.::::.:::: CCDS75 KLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLC 160 170 180 190 200 210 140 150 160 170 180 190 pF1KE3 QYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLA :::..::::::: ::.::.:::::::.:::....::::::::::::: ::::::::::: CCDS75 QYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLA 220 230 240 250 260 270 200 210 220 230 240 250 pF1KE3 RAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNI ::::.::.:::.:::::::::::.:::.::::. ::.::.::::.::.:: :::...: CCDS75 RAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDI 280 290 300 310 320 330 260 270 280 290 300 310 pF1KE3 LEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQ .:::.:. :::.:.::::::: .::...:: : : . ..:. .::.:. : .::::::. CCDS75 QDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASK 340 350 360 370 380 390 320 330 340 pF1KE3 MLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDE .:. :..:.::: :: :.::: :: .:..: : CCDS75 LLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFGKNN 400 410 420 430 440 450 CCDS75 SYGKSLSNSKH 460 >>CCDS75628.1 CDK14 gene_id:5218|Hs108|chr7 (340 aa) initn: 1340 init1: 1340 opt: 1352 Z-score: 877.2 bits: 170.7 E(32554): 1.5e-42 Smith-Waterman score: 1353; 66.8% identity (86.5% similar) in 304 aa overlap (45-348:8-302) 20 30 40 50 60 70 pF1KE3 QKFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKGISRIN : :.:.: ::: :. : .:.: CCDS75 MLALTLRPPPLAKSHL---KLG-GTPAP-----ARVN 10 20 80 90 100 110 120 130 pF1KE3 GQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDL :.::::::: .. :::.:::::::::::::::::::::::::::::::::.::::.:::: CCDS75 GKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDL 30 40 50 60 70 80 140 150 160 170 180 190 pF1KE3 AQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGL :::..::::::: ::.::.:::::::.:::....::::::::::::: :::::::::: CCDS75 CQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGL 90 100 110 120 130 140 200 210 220 230 240 250 pF1KE3 ARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSN :::::.::.:::.:::::::::::.:::.::::. ::.::.::::.::.:: :::... CCDS75 ARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKD 150 160 170 180 190 200 260 270 280 290 300 310 pF1KE3 ILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLAS : .:::.:. :::.:.::::::: .::...:: : : . ..:. .::.:. : .:::::: CCDS75 IQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLAS 210 220 230 240 250 260 320 330 340 pF1KE3 QMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDE ..:. :..:.::: :: :.::: :: .:..: : CCDS75 KLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFGKN 270 280 290 300 310 320 CCDS75 NSYGKSLSNSKH 330 340 >>CCDS14276.1 CDK16 gene_id:5127|Hs108|chrX (496 aa) initn: 1145 init1: 955 opt: 1141 Z-score: 742.9 bits: 146.4 E(32554): 4.7e-35 Smith-Waterman score: 1141; 57.2% identity (82.6% similar) in 304 aa overlap (46-348:159-458) 20 30 40 50 60 70 pF1KE3 KFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKGISRING :: .:..:.:::::.::::::: :... CCDS14 GYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTD 130 140 150 160 170 180 80 90 100 110 120 130 pF1KE3 QLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLA .::::: : .. :::.: :::::.:::: ::::::: :::::::...::.::::. :: CCDS14 NLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLK 190 200 210 220 230 240 140 150 160 170 180 190 pF1KE3 QYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLA ::... . .. :::.::.::::::::: :.:.:::::::::::::.. ::::::::::: CCDS14 QYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLA 250 260 270 280 290 300 200 210 220 230 240 250 pF1KE3 RAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNI ::::::..:::.::::::::::: :::.:.::...:.::.:::: :: :.::::: :.. CCDS14 RAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPG-STV 310 320 330 340 350 360 260 270 280 290 300 310 pF1KE3 LEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVP-EAEDLAS :::. :...::.:::.::::. : : . . . : :. ... .. :. .. :: . CCDS14 EEQLHFIFRILGTPTEETWPGI--LSNEEFKTYNYPKYRA-EALLSHAPRLDSDGADLLT 370 380 390 400 410 420 320 330 340 pF1KE3 QMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDE ..:. :.:.::..:. : .: .: ....::: CCDS14 KLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDS 430 440 450 460 470 480 CCDS14 GRPAFRVVDTEF 490 >>CCDS48101.1 CDK16 gene_id:5127|Hs108|chrX (502 aa) initn: 1145 init1: 955 opt: 1141 Z-score: 742.8 bits: 146.4 E(32554): 4.7e-35 Smith-Waterman score: 1141; 57.2% identity (82.6% similar) in 304 aa overlap (46-348:165-464) 20 30 40 50 60 70 pF1KE3 KFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKGISRING :: .:..:.:::::.::::::: :... CCDS48 GYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTD 140 150 160 170 180 190 80 90 100 110 120 130 pF1KE3 QLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLA .::::: : .. :::.: :::::.:::: ::::::: :::::::...::.::::. :: CCDS48 NLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLK 200 210 220 230 240 250 140 150 160 170 180 190 pF1KE3 QYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLA ::... . .. :::.::.::::::::: :.:.:::::::::::::.. ::::::::::: CCDS48 QYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLA 260 270 280 290 300 310 200 210 220 230 240 250 pF1KE3 RAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNI ::::::..:::.::::::::::: :::.:.::...:.::.:::: :: :.::::: :.. CCDS48 RAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPG-STV 320 330 340 350 360 370 260 270 280 290 300 310 pF1KE3 LEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVP-EAEDLAS :::. :...::.:::.::::. : : . . . : :. ... .. :. .. :: . CCDS48 EEQLHFIFRILGTPTEETWPGI--LSNEEFKTYNYPKYRA-EALLSHAPRLDSDGADLLT 380 390 400 410 420 430 320 330 340 pF1KE3 QMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDE ..:. :.:.::..:. : .: .: ....::: CCDS48 KLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDS 440 450 460 470 480 490 CCDS48 GRPAFRVVDTEF 500 >>CCDS55408.1 CDK16 gene_id:5127|Hs108|chrX (570 aa) initn: 1145 init1: 955 opt: 1141 Z-score: 742.2 bits: 146.5 E(32554): 5.1e-35 Smith-Waterman score: 1141; 57.2% identity (82.6% similar) in 304 aa overlap (46-348:233-532) 20 30 40 50 60 70 pF1KE3 KFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKGISRING :: .:..:.:::::.::::::: :... CCDS55 GYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTD 210 220 230 240 250 260 80 90 100 110 120 130 pF1KE3 QLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLA .::::: : .. :::.: :::::.:::: ::::::: :::::::...::.::::. :: CCDS55 NLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLK 270 280 290 300 310 320 140 150 160 170 180 190 pF1KE3 QYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLA ::... . .. :::.::.::::::::: :.:.:::::::::::::.. ::::::::::: CCDS55 QYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLA 330 340 350 360 370 380 200 210 220 230 240 250 pF1KE3 RAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNI ::::::..:::.::::::::::: :::.:.::...:.::.:::: :: :.::::: :.. CCDS55 RAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPG-STV 390 400 410 420 430 440 260 270 280 290 300 310 pF1KE3 LEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVP-EAEDLAS :::. :...::.:::.::::. : : . . . : :. ... .. :. .. :: . CCDS55 EEQLHFIFRILGTPTEETWPGI--LSNEEFKTYNYPKYRA-EALLSHAPRLDSDGADLLT 450 460 470 480 490 320 330 340 pF1KE3 QMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDE ..:. :.:.::..:. : .: .: ....::: CCDS55 KLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDS 500 510 520 530 540 550 CCDS55 GRPAFRVVDTEF 560 570 349 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 18 17:33:39 2016 done: Fri Nov 18 17:33:40 2016 Total Scan time: 2.610 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]