Result of FASTA (omim) for
pF1KE3911
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3911, 710 aa
1>>>pF1KE3911 710 - 710 aa - 710 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.4845+/-0.000449; mu= 0.4482+/- 0.028
mean_var=247.6843+/-51.388, 0's: 0 Z-trim(118.4): 168 B-trim: 1004 in 1/55
Lambda= 0.081494
statistics sampled from 31057 (31236) to 31057 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.703), E-opt: 0.2 (0.366), width: 16
Scan time: 13.390
The best scores are: opt bits E(85289)
XP_011509225 (OMIM: 605991) PREDICTED: ephexin-1 i ( 710) 4700 566.4 1.3e-160
NP_062824 (OMIM: 605991) ephexin-1 isoform 1 [Homo ( 710) 4700 566.4 1.3e-160
NP_001107562 (OMIM: 605991) ephexin-1 isoform 2 [H ( 618) 3841 465.4 3e-130
XP_011509226 (OMIM: 605991) PREDICTED: ephexin-1 i ( 433) 2842 347.8 5.2e-95
XP_011509227 (OMIM: 605991) PREDICTED: ephexin-1 i ( 433) 2842 347.8 5.2e-95
NP_694945 (OMIM: 612496) rho guanine nucleotide ex ( 802) 1216 156.9 2.9e-37
XP_011539008 (OMIM: 612496) PREDICTED: rho guanine ( 802) 1216 156.9 2.9e-37
NP_005426 (OMIM: 600888) rho guanine nucleotide ex (1597) 1222 157.8 3.1e-37
NP_079290 (OMIM: 608504) rho guanine nucleotide ex ( 841) 977 128.8 8.8e-29
NP_776089 (OMIM: 608504) rho guanine nucleotide ex ( 841) 977 128.8 8.8e-29
XP_011522038 (OMIM: 608504) PREDICTED: rho guanine ( 792) 592 83.5 3.5e-15
XP_011522036 (OMIM: 608504) PREDICTED: rho guanine ( 856) 592 83.5 3.8e-15
XP_011522037 (OMIM: 608504) PREDICTED: rho guanine ( 856) 592 83.5 3.8e-15
XP_011522039 (OMIM: 608504) PREDICTED: rho guanine ( 439) 482 70.4 1.8e-11
XP_016883926 (OMIM: 602442) PREDICTED: intersectin (1185) 361 56.5 7.2e-07
XP_016883925 (OMIM: 602442) PREDICTED: intersectin (1608) 361 56.6 9.1e-07
XP_016883924 (OMIM: 602442) PREDICTED: intersectin (1613) 361 56.6 9.2e-07
XP_016883923 (OMIM: 602442) PREDICTED: intersectin (1645) 361 56.6 9.3e-07
XP_016883922 (OMIM: 602442) PREDICTED: intersectin (1650) 361 56.6 9.3e-07
XP_016883919 (OMIM: 602442) PREDICTED: intersectin (1679) 361 56.6 9.5e-07
XP_016883918 (OMIM: 602442) PREDICTED: intersectin (1684) 361 56.6 9.5e-07
NP_001317939 (OMIM: 602442) intersectin-1 isoform (1716) 361 56.6 9.6e-07
XP_016883917 (OMIM: 602442) PREDICTED: intersectin (1721) 361 56.6 9.6e-07
NP_003015 (OMIM: 602442) intersectin-1 isoform ITS (1721) 361 56.6 9.6e-07
NP_062541 (OMIM: 604464) intersectin-2 isoform 3 [ (1670) 352 55.5 2e-06
NP_006268 (OMIM: 604464) intersectin-2 isoform 1 [ (1697) 352 55.5 2e-06
NP_945328 (OMIM: 601855) rho guanine nucleotide ex ( 879) 310 50.4 3.7e-05
NP_004697 (OMIM: 601855) rho guanine nucleotide ex ( 912) 310 50.4 3.8e-05
NP_945353 (OMIM: 601855) rho guanine nucleotide ex ( 927) 310 50.4 3.8e-05
XP_005259447 (OMIM: 601855) PREDICTED: rho guanine ( 981) 310 50.4 4e-05
XP_016872911 (OMIM: 604763) PREDICTED: rho guanine (1401) 307 50.2 6.7e-05
XP_011541022 (OMIM: 604763) PREDICTED: rho guanine (1441) 307 50.2 6.9e-05
XP_016872910 (OMIM: 604763) PREDICTED: rho guanine (1441) 307 50.2 6.9e-05
NP_001288013 (OMIM: 604763) rho guanine nucleotide (1441) 307 50.2 6.9e-05
XP_016872909 (OMIM: 604763) PREDICTED: rho guanine (1485) 307 50.2 7e-05
XP_006718868 (OMIM: 604763) PREDICTED: rho guanine (1519) 307 50.2 7.1e-05
NP_001185594 (OMIM: 604763) rho guanine nucleotide (1525) 307 50.2 7.2e-05
NP_056128 (OMIM: 604763) rho guanine nucleotide ex (1544) 307 50.2 7.2e-05
XP_011525770 (OMIM: 601855) PREDICTED: rho guanine ( 985) 301 49.3 8.3e-05
NP_001317303 (OMIM: 609311,611104) FYVE, RhoGEF an ( 673) 284 47.2 0.00025
NP_001317302 (OMIM: 609311,611104) FYVE, RhoGEF an ( 673) 284 47.2 0.00025
XP_005253365 (OMIM: 609311,611104) PREDICTED: FYVE ( 673) 284 47.2 0.00025
XP_005253366 (OMIM: 609311,611104) PREDICTED: FYVE ( 673) 284 47.2 0.00025
XP_011518860 (OMIM: 609311,611104) PREDICTED: FYVE ( 567) 282 46.9 0.00026
XP_011518857 (OMIM: 609311,611104) PREDICTED: FYVE ( 766) 284 47.3 0.00027
NP_640334 (OMIM: 609311,611104) FYVE, RhoGEF and P ( 766) 284 47.3 0.00027
XP_011518858 (OMIM: 609311,611104) PREDICTED: FYVE ( 766) 284 47.3 0.00027
XP_005259443 (OMIM: 601855) PREDICTED: rho guanine (1041) 286 47.6 0.0003
NP_001291410 (OMIM: 609311,611104) FYVE, RhoGEF an ( 851) 284 47.3 0.0003
XP_011518856 (OMIM: 609311,611104) PREDICTED: FYVE ( 864) 284 47.3 0.0003
>>XP_011509225 (OMIM: 605991) PREDICTED: ephexin-1 isofo (710 aa)
initn: 4700 init1: 4700 opt: 4700 Z-score: 3004.4 bits: 566.4 E(85289): 1.3e-160
Smith-Waterman score: 4700; 99.9% identity (99.9% similar) in 710 aa overlap (1-710:1-710)
10 20 30 40 50 60
pF1KE3 METRESEDLEKTRRKSASDQWNTDNEPAKVKPELLPEKEETSQADQDIQDKEPHCHIPIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 METRESEDLEKTRRKSASDQWNTDNEPAKVKPELLPEKEETSQADQDIQDKEPHCHIPIK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 RNSIFNRSIRRKSKAKARDNPERNASCLADSQDNGKSVNEPLTLNIPWSRTPPCRTAMQT
:::::::::::::::::::::::::::::::::::::::::::::::::: :::::::::
XP_011 RNSIFNRSIRRKSKAKARDNPERNASCLADSQDNGKSVNEPLTLNIPWSRMPPCRTAMQT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 DPGAQEMSESSSTPGNGATPEEWPALADSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DPGAQEMSESSSTPGNGATPEEWPALADSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 EYRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEEPASPPERKTLPQIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEEPASPPERKTLPQIC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 LLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 ENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 SVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 LLVQNILKRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLVQNILKRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 VPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 DSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 RTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQER
610 620 630 640 650 660
670 680 690 700 710
pF1KE3 GWFPSSMTEEILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQ
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GWFPSSMTEEILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQ
670 680 690 700 710
>>NP_062824 (OMIM: 605991) ephexin-1 isoform 1 [Homo sap (710 aa)
initn: 4700 init1: 4700 opt: 4700 Z-score: 3004.4 bits: 566.4 E(85289): 1.3e-160
Smith-Waterman score: 4700; 99.9% identity (99.9% similar) in 710 aa overlap (1-710:1-710)
10 20 30 40 50 60
pF1KE3 METRESEDLEKTRRKSASDQWNTDNEPAKVKPELLPEKEETSQADQDIQDKEPHCHIPIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 METRESEDLEKTRRKSASDQWNTDNEPAKVKPELLPEKEETSQADQDIQDKEPHCHIPIK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 RNSIFNRSIRRKSKAKARDNPERNASCLADSQDNGKSVNEPLTLNIPWSRTPPCRTAMQT
:::::::::::::::::::::::::::::::::::::::::::::::::: :::::::::
NP_062 RNSIFNRSIRRKSKAKARDNPERNASCLADSQDNGKSVNEPLTLNIPWSRMPPCRTAMQT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 DPGAQEMSESSSTPGNGATPEEWPALADSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 DPGAQEMSESSSTPGNGATPEEWPALADSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 EYRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEEPASPPERKTLPQIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 EYRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEEPASPPERKTLPQIC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 LLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 LLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 ENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 ENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 SVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 SVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 LLVQNILKRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 LLVQNILKRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 VPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 VPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 DSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 DSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 RTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 RTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQER
610 620 630 640 650 660
670 680 690 700 710
pF1KE3 GWFPSSMTEEILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQ
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 GWFPSSMTEEILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQ
670 680 690 700 710
>>NP_001107562 (OMIM: 605991) ephexin-1 isoform 2 [Homo (618 aa)
initn: 3839 init1: 3839 opt: 3841 Z-score: 2459.4 bits: 465.4 E(85289): 3e-130
Smith-Waterman score: 3841; 98.5% identity (98.8% similar) in 594 aa overlap (117-710:25-618)
90 100 110 120 130 140
pF1KE3 CLADSQDNGKSVNEPLTLNIPWSRTPPCRTAMQTDPGAQEMSESSSTPGNGATPEEWPAL
: .. : :::::::::::::::::::
NP_001 MELLAAAFSAACAVDHDSSTSESDARDSAAGHLPGSESSSTPGNGATPEEWPAL
10 20 30 40 50
150 160 170 180 190 200
pF1KE3 ADSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQEYRDKSTLQEIETRRQQDAEIEDNTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQEYRDKSTLQEIETRRQQDAEIEDNTN
60 70 80 90 100 110
210 220 230 240 250 260
pF1KE3 GSPASEDTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSPASEDTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEI
120 130 140 150 160 170
270 280 290 300 310 320
pF1KE3 LQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLA
180 190 200 210 220 230
330 340 350 360 370 380
pF1KE3 VSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAA
240 250 260 270 280 290
390 400 410 420 430 440
pF1KE3 FRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKE
300 310 320 330 340 350
450 460 470 480 490 500
pF1KE3 LEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSR
360 370 380 390 400 410
510 520 530 540 550 560
pF1KE3 TLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELEDQGQTLANVFIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELEDQGQTLANVFIL
420 430 440 450 460 470
570 580 590 600 610 620
pF1KE3 RLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYVAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYVAQ
480 490 500 510 520 530
630 640 650 660 670 680
pF1KE3 QPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLKECFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLKECFR
540 550 560 570 580 590
690 700 710
pF1KE3 VHKMDDPQRSQNKDRRKLGSRNRQ
::::::::::::::::::::::::
NP_001 VHKMDDPQRSQNKDRRKLGSRNRQ
600 610
>>XP_011509226 (OMIM: 605991) PREDICTED: ephexin-1 isofo (433 aa)
initn: 2842 init1: 2842 opt: 2842 Z-score: 1826.8 bits: 347.8 E(85289): 5.2e-95
Smith-Waterman score: 2842; 100.0% identity (100.0% similar) in 433 aa overlap (278-710:1-433)
250 260 270 280 290 300
pF1KE3 RFNLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRK
::::::::::::::::::::::::::::::
XP_011 MFELVTSEASYYKSLNLLVSHFMENERIRK
10 20 30
310 320 330 340 350 360
pF1KE3 ILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYV
40 50 60 70 80 90
370 380 390 400 410 420
pF1KE3 SNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNIL
100 110 120 130 140 150
430 440 450 460 470 480
pF1KE3 KRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHS
160 170 180 190 200 210
490 500 510 520 530 540
pF1KE3 RWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGL
220 230 240 250 260 270
550 560 570 580 590 600
pF1KE3 LRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSF
280 290 300 310 320 330
610 620 630 640 650 660
pF1KE3 TSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSM
340 350 360 370 380 390
670 680 690 700 710
pF1KE3 TEEILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQ
:::::::::::::::::::::::::::::::::::::::::::
XP_011 TEEILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQ
400 410 420 430
>>XP_011509227 (OMIM: 605991) PREDICTED: ephexin-1 isofo (433 aa)
initn: 2842 init1: 2842 opt: 2842 Z-score: 1826.8 bits: 347.8 E(85289): 5.2e-95
Smith-Waterman score: 2842; 100.0% identity (100.0% similar) in 433 aa overlap (278-710:1-433)
250 260 270 280 290 300
pF1KE3 RFNLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRK
::::::::::::::::::::::::::::::
XP_011 MFELVTSEASYYKSLNLLVSHFMENERIRK
10 20 30
310 320 330 340 350 360
pF1KE3 ILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYV
40 50 60 70 80 90
370 380 390 400 410 420
pF1KE3 SNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNIL
100 110 120 130 140 150
430 440 450 460 470 480
pF1KE3 KRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHS
160 170 180 190 200 210
490 500 510 520 530 540
pF1KE3 RWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGL
220 230 240 250 260 270
550 560 570 580 590 600
pF1KE3 LRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSF
280 290 300 310 320 330
610 620 630 640 650 660
pF1KE3 TSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSM
340 350 360 370 380 390
670 680 690 700 710
pF1KE3 TEEILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQ
:::::::::::::::::::::::::::::::::::::::::::
XP_011 TEEILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQ
400 410 420 430
>>NP_694945 (OMIM: 612496) rho guanine nucleotide exchan (802 aa)
initn: 1220 init1: 1180 opt: 1216 Z-score: 789.9 bits: 156.9 E(85289): 2.9e-37
Smith-Waterman score: 1241; 35.3% identity (63.4% similar) in 688 aa overlap (32-687:106-790)
10 20 30 40 50 60
pF1KE3 ETRESEDLEKTRRKSASDQWNTDNEPAKVKPELLPEKEETSQADQDIQDKEPHCHIPIKR
: : : . . : .. : :.
NP_694 LLWPLSPGGSDTEITSGGMRPSRAGSWPHCPGAQPPALEGPWSPRHTQPQRRASHGSEKK
80 90 100 110 120 130
70 80 90 100
pF1KE3 NSIFNRSIRRKSKAKARDNPERNASCLADSQ---DNGKSVNEP---------LTLNIPWS
.. :..: .. .. :: .: : .: ... :..:: ..:. :
NP_694 SAW--RKMRVYQREEVPGCPEAHAVFLEPGQVVQEQALSTEEPRVELSGSTRVSLEGPER
140 150 160 170 180 190
110 120 130 140 150 160
pF1KE3 RTPPCRTAMQTDPGAQEMSESS------STPGNGATPEEWPALADSPTTLTEALRMIHPI
: : .. .....: : :.::. : . .. .. . :. .:
NP_694 RRFSASELMTRLHSSLRLGRNSAARALISGSGTGAAREGKASGMEARSVEMSGDRVSRPA
200 210 220 230 240 250
170 180 190 200 210
pF1KE3 PADSWRNLIEQIGLLYQE---YRDKSTLQEIETRRQQDA----EIEDNTNGSPASEDTPE
:.:: .. . : :: ..:: .. ..: .. : : ... .. :
NP_694 PGDSREGDWSEPRLDTQEEPPLGSRSTNERRQSRFLLNSVLYQEYSDVASARELRRQQRE
260 270 280 290 300 310
220 230 240 250 260 270
pF1KE3 EE---EEEEEEEEPASPPERKTLPQICLLSNPHSR---FNLWQDLPEIRSSGVLEILQPE
:: .: : :: .::. . :. . .. .: :.::::.:..:.:::: :. .
NP_694 EEGPGDEAEGAEEGPGPPRANLSPSSSFRAQRSARGSTFSLWQDIPDVRGSGVLATLSLR
320 330 340 350 360 370
280 290 300 310 320 330
pF1KE3 EIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLAVSER
. ::::: :::.:::::: .::.. :.::. . .. . : .. . :::.. .: ..:::
NP_694 DCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELSECLGAQDKQWLFSKLPEVKSTSER
380 390 400 410 420 430
340 350 360 370 380 390
pF1KE3 FLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFREL
:: .::.:.: ... .:::.: . ::. ::.::.::::::..:: :. : .
NP_694 FLQDLEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRLLLENPRFPGI
440 450 460 470 480 490
400 410 420 430 440 450
pF1KE3 IAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKELEMV
.:.:: .: :. ::..::::::::::::::.::.:::::. . :: : : : . :. .
NP_694 LARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFNALKEL
500 510 520 530 540 550
460 470 480 490 500 510
pF1KE3 VKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRT
:. :: .:..:.:::..: ..::..:. : :.::..:::...::: ... .. .
NP_694 VQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELVELAPLPAAPPAKL
560 570 580 590 600 610
520 530 540 550 560
pF1KE3 KKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELEDQGQTL-ANVFILRLL
: . .:: :::: :.. :. :. :: : . :.:..: . : . ..::.:.::
NP_694 KLSSKAVYLHLFNDCLLLSRRKELGKFAVFVHAKMAELQVRDLSLKLQGIPGHVFLLQLL
620 630 640 650 660 670
570 580 590 600 610 620
pF1KE3 ENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYVAQQPD
... . ..:.: ..:: .::...: :. . :. ::::::::. : : .::
NP_694 -HGQHMKHQFLLRARTESEKQRWISALCPSSPQEDKEVISEGEDCPQVQCVRTYKALHPD
680 690 700 710 720 730
630 640 650 660 670 680
pF1KE3 ELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLKECFRVHK
::::: .:::.. :.:::. : :: : :.:: :....::: . . : .::.: ::
NP_694 ELTLEKTDILSVRTWTSDGWLEGVRLADGEKGWVPQAYVEEISSLSARLRNLRENKRVTS
740 750 760 770 780 790
690 700 710
pF1KE3 MDDPQRSQNKDRRKLGSRNRQ
NP_694 ATSKLGEAPV
800
>>XP_011539008 (OMIM: 612496) PREDICTED: rho guanine nuc (802 aa)
initn: 1220 init1: 1180 opt: 1216 Z-score: 789.9 bits: 156.9 E(85289): 2.9e-37
Smith-Waterman score: 1241; 35.3% identity (63.4% similar) in 688 aa overlap (32-687:106-790)
10 20 30 40 50 60
pF1KE3 ETRESEDLEKTRRKSASDQWNTDNEPAKVKPELLPEKEETSQADQDIQDKEPHCHIPIKR
: : : . . : .. : :.
XP_011 LLWPLSPGGSDTEITSGGMRPSRAGSWPHCPGAQPPALEGPWSPRHTQPQRRASHGSEKK
80 90 100 110 120 130
70 80 90 100
pF1KE3 NSIFNRSIRRKSKAKARDNPERNASCLADSQ---DNGKSVNEP---------LTLNIPWS
.. :..: .. .. :: .: : .: ... :..:: ..:. :
XP_011 SAW--RKMRVYQREEVPGCPEAHAVFLEPGQVVQEQALSTEEPRVELSGSTRVSLEGPER
140 150 160 170 180 190
110 120 130 140 150 160
pF1KE3 RTPPCRTAMQTDPGAQEMSESS------STPGNGATPEEWPALADSPTTLTEALRMIHPI
: : .. .....: : :.::. : . .. .. . :. .:
XP_011 RRFSASELMTRLHSSLRLGRNSAARALISGSGTGAAREGKASGMEARSVEMSGDRVSRPA
200 210 220 230 240 250
170 180 190 200 210
pF1KE3 PADSWRNLIEQIGLLYQE---YRDKSTLQEIETRRQQDA----EIEDNTNGSPASEDTPE
:.:: .. . : :: ..:: .. ..: .. : : ... .. :
XP_011 PGDSREGDWSEPRLDTQEEPPLGSRSTNERRQSRFLLNSVLYQEYSDVASARELRRQQRE
260 270 280 290 300 310
220 230 240 250 260 270
pF1KE3 EE---EEEEEEEEPASPPERKTLPQICLLSNPHSR---FNLWQDLPEIRSSGVLEILQPE
:: .: : :: .::. . :. . .. .: :.::::.:..:.:::: :. .
XP_011 EEGPGDEAEGAEEGPGPPRANLSPSSSFRAQRSARGSTFSLWQDIPDVRGSGVLATLSLR
320 330 340 350 360 370
280 290 300 310 320 330
pF1KE3 EIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLAVSER
. ::::: :::.:::::: .::.. :.::. . .. . : .. . :::.. .: ..:::
XP_011 DCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELSECLGAQDKQWLFSKLPEVKSTSER
380 390 400 410 420 430
340 350 360 370 380 390
pF1KE3 FLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFREL
:: .::.:.: ... .:::.: . ::. ::.::.::::::..:: :. : .
XP_011 FLQDLEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRLLLENPRFPGI
440 450 460 470 480 490
400 410 420 430 440 450
pF1KE3 IAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKELEMV
.:.:: .: :. ::..::::::::::::::.::.:::::. . :: : : : . :. .
XP_011 LARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFNALKEL
500 510 520 530 540 550
460 470 480 490 500 510
pF1KE3 VKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRT
:. :: .:..:.:::..: ..::..:. : :.::..:::...::: ... .. .
XP_011 VQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELVELAPLPAAPPAKL
560 570 580 590 600 610
520 530 540 550 560
pF1KE3 KKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELEDQGQTL-ANVFILRLL
: . .:: :::: :.. :. :. :: : . :.:..: . : . ..::.:.::
XP_011 KLSSKAVYLHLFNDCLLLSRRKELGKFAVFVHAKMAELQVRDLSLKLQGIPGHVFLLQLL
620 630 640 650 660 670
570 580 590 600 610 620
pF1KE3 ENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYVAQQPD
... . ..:.: ..:: .::...: :. . :. ::::::::. : : .::
XP_011 -HGQHMKHQFLLRARTESEKQRWISALCPSSPQEDKEVISEGEDCPQVQCVRTYKALHPD
680 690 700 710 720 730
630 640 650 660 670 680
pF1KE3 ELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLKECFRVHK
::::: .:::.. :.:::. : :: : :.:: :....::: . . : .::.: ::
XP_011 ELTLEKTDILSVRTWTSDGWLEGVRLADGEKGWVPQAYVEEISSLSARLRNLRENKRVTS
740 750 760 770 780 790
690 700 710
pF1KE3 MDDPQRSQNKDRRKLGSRNRQ
XP_011 ATSKLGEAPV
800
>>NP_005426 (OMIM: 600888) rho guanine nucleotide exchan (1597 aa)
initn: 1121 init1: 801 opt: 1222 Z-score: 789.6 bits: 157.8 E(85289): 3.1e-37
Smith-Waterman score: 1267; 38.9% identity (64.6% similar) in 619 aa overlap (76-687:1001-1585)
50 60 70 80 90 100
pF1KE3 QDIQDKEPHCHIPIKRNSIFNRSIRRKSKAKARDNPERNASCLADSQDNGKSV--NEPLT
:: . :.: : ....:..: .: .
NP_005 TTPQQGASGPGRSPVGQARQPEKPSHLHLEKASSWPHRRDSGRPPGDSSGQAVAPSEGAN
980 990 1000 1010 1020 1030
110 120 130 140 150 160
pF1KE3 LNIPWSRTPPCRTAMQTDPGAQEMSESSSTPGNGATPEEWPALADSPTTLTEALRMIHPI
. ::: : .. . :.:: . : . :. :. .:. . . . .
NP_005 KHKGWSRQGLRRPSI--------LPEGSSD-SRGPAVEKHPGPSDTVVFREKKPKEVMGG
1040 1050 1060 1070 1080
170 180 190 200 210 220
pF1KE3 PADSWRNLIEQIGLLYQEYRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEE
. .::.. :::::: : .::.. :: : ..: : :.: :..
NP_005 FSRRCSKLINSSQLLYQEYSDVVLNKEIQS--QQRLESLSETPG-PSSPRQPRK------
1090 1100 1110 1120 1130
230 240 250 260 270 280
pF1KE3 EEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVT
: .. : .. . :. .:::..: .:.: :: . :. ::::. :::..
NP_005 ----ALVSSESYLQRLSMASSG----SLWQEIPVVRNSTVLLSMTHEDQKLQEVKFELIV
1140 1150 1160 1170 1180
290 300 310 320 330 340
pF1KE3 SEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENI
::::: .:::. :.::. . .: : .: . ::: . :: :: :: .::. .:.::
NP_005 SEASYLRSLNIAVDHFQLSTSLRATLSNQEHQWLFSRLQDVRDVSATFLSDLEENFENNI
1190 1200 1210 1220 1230 1240
350 360 370 380 390 400
pF1KE3 VISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGL
.:::.: .: : ::. ::.::::::::...:.. .. :::.. .:: :: :. :
NP_005 FSFQVCDVVLNHAPDFRRVYLPYVTNQTYQERTFQSLMNSNSNFREVLEKLESDPVCQRL
1250 1260 1270 1280 1290 1300
410 420 430 440 450 460
pF1KE3 PFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKELEMVVKACNEGVRKMSR
..::::::::::::::::.::::::.. : .: : ::. ::.... ::..:..: :
NP_005 SLKSFLILPFQRITRLKLLLQNILKRTQPGSSEEAEATKAHHALEQLIRDCNNNVQSMRR
1310 1320 1330 1340 1350 1360
470 480 490 500 510 520
pF1KE3 TEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFN
::..: ...:.::. : :.::.::::.:.::: . ..: :: : . ..: :::
NP_005 TEELIYLSQKIEFECKIFPLISQSRWLVKSGELTALEF-SASPGLRRKLNTRPVHLHLFN
1370 1380 1390 1400 1410 1420
530 540 550 560 570 580
pF1KE3 DLLVICRQIPGDKYQVFDSAPRGLLRVE--ELEDQGQTLANVFILRLLENADDREATYML
: :.. : :... ::: :: . .: : :.. .: :.: : : .:.. .: ...
NP_005 DCLLLSRPREGSRFLVFDHAPFSSIRGEKCEMKLHGPH-KNLFRLFLRQNTQGAQAEFLF
1430 1440 1450 1460 1470 1480
590 600 610 620 630
pF1KE3 KASSQSEMKRWMTSLAPNRRTKFVSFTSRLLDC---PQVQCVHPYVAQQPDELTLELADI
.. .::: ::...:: :. ::.: :::::.. : .. :::.:: ::.
NP_005 RTETQSEKLRWISALAMPREEL------DLLECYNSPQVQCLRAYKPRENDELALEKADV
1490 1500 1510 1520 1530
640 650 660 670 680 690
pF1KE3 LNILDKTDDGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLKECFRVHKMDDPQRSQN
. . ....:::. : :: : :::::: ...: : ::..:.::::: ::
NP_005 VMVTQQSSDGWLEGVRLSDGERGWFPVQQVEFISNPEVRAQNLKEAHRVKTAKLQLVEQQ
1540 1550 1560 1570 1580 1590
700 710
pF1KE3 KDRRKLGSRNRQ
NP_005 A
>>NP_079290 (OMIM: 608504) rho guanine nucleotide exchan (841 aa)
initn: 870 init1: 689 opt: 977 Z-score: 637.8 bits: 128.8 E(85289): 8.8e-29
Smith-Waterman score: 978; 33.2% identity (60.7% similar) in 590 aa overlap (106-687:275-825)
80 90 100 110 120
pF1KE3 KARDNPERNASCLADSQDNGKSVNEPLTLNIPWSRTP-PCRTAMQT----DPGAQEMSE-
.: . : : :. ... :: ...
NP_079 RTSRSRPHPPSIGHPAVVLTSYRSTAERKLLPLLKPPKPTRVRQDATIFGDPPQPDLDLL
250 260 270 280 290 300
130 140 150 160 170 180
pF1KE3 SSSTPGNGATPEEWPALADSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQEYRDKSTLQ
: . .: .:.: : . :. . . .. . ..:. : : ::: :: .
NP_079 SEDGIQTGDSPDEAPQNTPPATVEGREEEGLEVLKEQNWE-LPLQDEPLYQTYRAAVLSE
310 320 330 340 350 360
190 200 210 220 230 240
pF1KE3 EIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRF
:. . :: :::. ::. . :.:. : :
NP_079 ELW------GVGED---GSPS----------------PANAGDAPTFPR-----PPGPRN
370 380 390
250 260 270 280 290 300
pF1KE3 NLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKIL
.:::.:: ...::.:. :.:.: ..::..::.::::::: .:: ::.. :. .. .: :
NP_079 TLWQELPAVQASGLLDTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTL
400 410 420 430 440 450
310 320 330 340 350 360
pF1KE3 HPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSN
: . : ::::: : .:::::: : :.. . :::.::.:. .:. ::::. :: :
NP_079 TPRDHHTLFSNVQRVQGVSERFLATLLSRVRSSPHISDLCDVVHAHAVGPFSVYVDYVRN
460 470 480 490 500 510
370 380 390 400 410 420
pF1KE3 QTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKR
: :::.::..:.. .. : . .:. :::. ::. :::.:::::::::..:.::::..
NP_079 QQYQEETYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQ
520 530 540 550 560 570
430 440 450 460 470 480
pF1KE3 VEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEF-KIKSVPIISHSR
.:: : :. .: : . ... :. : .:..::..: . ....: :.:..:..: ::
NP_079 TEEGSSRQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSR
580 590 600 610 620 630
490 500 510 520 530 540
pF1KE3 WLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLL
: :::: ... . . . .. : . :.::.:::.: . :.. ::.: : :.:.
NP_079 RLEFQGELTELGCRRGGVLFASRPRFTPLCLLLFSDLLLITQPKSGQRLQVLDYAHRSLV
640 650 660 670 680 690
550 560 570 580 590 600
pF1KE3 RVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSL-APNRRTKFVSF
..... : . .: : :: : . : . .:.::: :.:.::. .. .:. .
NP_079 QAQQVPDPSGP--PTFRLSLLSNHQGRPTHRLLQASSLSDMQRWLGAFPTPGPLPCSPDT
700 710 720 730 740 750
610 620 630 640 650 660
pF1KE3 TSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSM
. :: : : . . . . .:: . : :: .::. : : ::...
NP_079 IYEDCDCSQELCSESSAPAKTEGRSLESRAAPKHLHKTPEGWLKGL------PGAFPAQL
760 770 780 790 800
670 680 690 700 710
pF1KE3 TEEILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQ
. :. . . : ..:.. :.
NP_079 VCEVTGEHERRRHLRQNQRLLEAVGSSSGTPNAPPP
810 820 830 840
>>NP_776089 (OMIM: 608504) rho guanine nucleotide exchan (841 aa)
initn: 870 init1: 689 opt: 977 Z-score: 637.8 bits: 128.8 E(85289): 8.8e-29
Smith-Waterman score: 978; 33.2% identity (60.7% similar) in 590 aa overlap (106-687:275-825)
80 90 100 110 120
pF1KE3 KARDNPERNASCLADSQDNGKSVNEPLTLNIPWSRTP-PCRTAMQT----DPGAQEMSE-
.: . : : :. ... :: ...
NP_776 RTSRSRPHPPSIGHPAVVLTSYRSTAERKLLPLLKPPKPTRVRQDATIFGDPPQPDLDLL
250 260 270 280 290 300
130 140 150 160 170 180
pF1KE3 SSSTPGNGATPEEWPALADSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQEYRDKSTLQ
: . .: .:.: : . :. . . .. . ..:. : : ::: :: .
NP_776 SEDGIQTGDSPDEAPQNTPPATVEGREEEGLEVLKEQNWE-LPLQDEPLYQTYRAAVLSE
310 320 330 340 350 360
190 200 210 220 230 240
pF1KE3 EIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRF
:. . :: :::. ::. . :.:. : :
NP_776 ELW------GVGED---GSPS----------------PANAGDAPTFPR-----PPGPRN
370 380 390
250 260 270 280 290 300
pF1KE3 NLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKIL
.:::.:: ...::.:. :.:.: ..::..::.::::::: .:: ::.. :. .. .: :
NP_776 TLWQELPAVQASGLLDTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTL
400 410 420 430 440 450
310 320 330 340 350 360
pF1KE3 HPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSN
: . : ::::: : .:::::: : :.. . :::.::.:. .:. ::::. :: :
NP_776 TPRDHHTLFSNVQRVQGVSERFLATLLSRVRSSPHISDLCDVVHAHAVGPFSVYVDYVRN
460 470 480 490 500 510
370 380 390 400 410 420
pF1KE3 QTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKR
: :::.::..:.. .. : . .:. :::. ::. :::.:::::::::..:.::::..
NP_776 QQYQEETYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQ
520 530 540 550 560 570
430 440 450 460 470 480
pF1KE3 VEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEF-KIKSVPIISHSR
.:: : :. .: : . ... :. : .:..::..: . ....: :.:..:..: ::
NP_776 TEEGSSRQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSR
580 590 600 610 620 630
490 500 510 520 530 540
pF1KE3 WLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLL
: :::: ... . . . .. : . :.::.:::.: . :.. ::.: : :.:.
NP_776 RLEFQGELTELGCRRGGVLFASRPRFTPLCLLLFSDLLLITQPKSGQRLQVLDYAHRSLV
640 650 660 670 680 690
550 560 570 580 590 600
pF1KE3 RVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSL-APNRRTKFVSF
..... : . .: : :: : . : . .:.::: :.:.::. .. .:. .
NP_776 QAQQVPDPSGP--PTFRLSLLSNHQGRPTHRLLQASSLSDMQRWLGAFPTPGPLPCSPDT
700 710 720 730 740 750
610 620 630 640 650 660
pF1KE3 TSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSM
. :: : : . . . . .:: . : :: .::. : : ::...
NP_776 IYEDCDCSQELCSESSAPAKTEGRSLESRAAPKHLHKTPEGWLKGL------PGAFPAQL
760 770 780 790 800
670 680 690 700 710
pF1KE3 TEEILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQ
. :. . . : ..:.. :.
NP_776 VCEVTGEHERRRHLRQNQRLLEAVGSSSGTPNAPPP
810 820 830 840
710 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 09:02:24 2016 done: Sun Nov 6 09:02:26 2016
Total Scan time: 13.390 Total Display time: 0.160
Function used was FASTA [36.3.4 Apr, 2011]