FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3935, 466 aa 1>>>pF1KE3935 466 - 466 aa - 466 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.6123+/-0.000391; mu= -4.0964+/- 0.025 mean_var=338.3378+/-69.781, 0's: 0 Z-trim(122.9): 16 B-trim: 2193 in 2/57 Lambda= 0.069727 statistics sampled from 41651 (41673) to 41651 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.785), E-opt: 0.2 (0.489), width: 16 Scan time: 11.730 The best scores are: opt bits E(85289) NP_005745 (OMIM: 608431) ras GTPase-activating pro ( 466) 3191 334.4 3.9e-91 XP_016864411 (OMIM: 608431) PREDICTED: ras GTPase- ( 466) 3191 334.4 3.9e-91 XP_006714813 (OMIM: 608431) PREDICTED: ras GTPase- ( 466) 3191 334.4 3.9e-91 XP_006714812 (OMIM: 608431) PREDICTED: ras GTPase- ( 466) 3191 334.4 3.9e-91 XP_016864412 (OMIM: 608431) PREDICTED: ras GTPase- ( 466) 3191 334.4 3.9e-91 NP_938405 (OMIM: 608431) ras GTPase-activating pro ( 466) 3191 334.4 3.9e-91 >>NP_005745 (OMIM: 608431) ras GTPase-activating protein (466 aa) initn: 3191 init1: 3191 opt: 3191 Z-score: 1757.2 bits: 334.4 E(85289): 3.9e-91 Smith-Waterman score: 3191; 100.0% identity (100.0% similar) in 466 aa overlap (1-466:1-466) 10 20 30 40 50 60 pF1KE3 MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 IHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 IHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 ANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQAVVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQAVVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 NDMEEHLEEPVAEPEPDPEPEPEQEPVSEIQEEKPEPVLEETAPEDAQKSSSPAPADIAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NDMEEHLEEPVAEPEPDPEPEPEQEPVSEIQEEKPEPVLEETAPEDAQKSSSPAPADIAQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 TVQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPPQRPQRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TVQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPPQRPQRD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 QRVREQRINIPPQRGPRPIREAGEQGDIEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 QRVREQRINIPPQRGPRPIREAGEQGDIEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 QSYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 QSYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAARE 370 380 390 400 410 420 430 440 450 460 pF1KE3 GDRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRGLAPRQ :::::::::::::::::::::::::::::::::::::::::::::: NP_005 GDRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRGLAPRQ 430 440 450 460 >>XP_016864411 (OMIM: 608431) PREDICTED: ras GTPase-acti (466 aa) initn: 3191 init1: 3191 opt: 3191 Z-score: 1757.2 bits: 334.4 E(85289): 3.9e-91 Smith-Waterman score: 3191; 100.0% identity (100.0% similar) in 466 aa overlap (1-466:1-466) 10 20 30 40 50 60 pF1KE3 MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 IHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 ANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQAVVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQAVVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 NDMEEHLEEPVAEPEPDPEPEPEQEPVSEIQEEKPEPVLEETAPEDAQKSSSPAPADIAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NDMEEHLEEPVAEPEPDPEPEPEQEPVSEIQEEKPEPVLEETAPEDAQKSSSPAPADIAQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 TVQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPPQRPQRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPPQRPQRD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 QRVREQRINIPPQRGPRPIREAGEQGDIEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QRVREQRINIPPQRGPRPIREAGEQGDIEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 QSYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAARE 370 380 390 400 410 420 430 440 450 460 pF1KE3 GDRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRGLAPRQ :::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRGLAPRQ 430 440 450 460 >>XP_006714813 (OMIM: 608431) PREDICTED: ras GTPase-acti (466 aa) initn: 3191 init1: 3191 opt: 3191 Z-score: 1757.2 bits: 334.4 E(85289): 3.9e-91 Smith-Waterman score: 3191; 100.0% identity (100.0% similar) in 466 aa overlap (1-466:1-466) 10 20 30 40 50 60 pF1KE3 MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 IHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 ANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQAVVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQAVVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 NDMEEHLEEPVAEPEPDPEPEPEQEPVSEIQEEKPEPVLEETAPEDAQKSSSPAPADIAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NDMEEHLEEPVAEPEPDPEPEPEQEPVSEIQEEKPEPVLEETAPEDAQKSSSPAPADIAQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 TVQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPPQRPQRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TVQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPPQRPQRD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 QRVREQRINIPPQRGPRPIREAGEQGDIEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QRVREQRINIPPQRGPRPIREAGEQGDIEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 QSYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QSYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAARE 370 380 390 400 410 420 430 440 450 460 pF1KE3 GDRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRGLAPRQ :::::::::::::::::::::::::::::::::::::::::::::: XP_006 GDRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRGLAPRQ 430 440 450 460 >>XP_006714812 (OMIM: 608431) PREDICTED: ras GTPase-acti (466 aa) initn: 3191 init1: 3191 opt: 3191 Z-score: 1757.2 bits: 334.4 E(85289): 3.9e-91 Smith-Waterman score: 3191; 100.0% identity (100.0% similar) in 466 aa overlap (1-466:1-466) 10 20 30 40 50 60 pF1KE3 MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 IHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 ANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQAVVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQAVVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 NDMEEHLEEPVAEPEPDPEPEPEQEPVSEIQEEKPEPVLEETAPEDAQKSSSPAPADIAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NDMEEHLEEPVAEPEPDPEPEPEQEPVSEIQEEKPEPVLEETAPEDAQKSSSPAPADIAQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 TVQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPPQRPQRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TVQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPPQRPQRD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 QRVREQRINIPPQRGPRPIREAGEQGDIEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QRVREQRINIPPQRGPRPIREAGEQGDIEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 QSYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QSYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAARE 370 380 390 400 410 420 430 440 450 460 pF1KE3 GDRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRGLAPRQ :::::::::::::::::::::::::::::::::::::::::::::: XP_006 GDRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRGLAPRQ 430 440 450 460 >>XP_016864412 (OMIM: 608431) PREDICTED: ras GTPase-acti (466 aa) initn: 3191 init1: 3191 opt: 3191 Z-score: 1757.2 bits: 334.4 E(85289): 3.9e-91 Smith-Waterman score: 3191; 100.0% identity (100.0% similar) in 466 aa overlap (1-466:1-466) 10 20 30 40 50 60 pF1KE3 MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 IHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 ANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQAVVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQAVVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 NDMEEHLEEPVAEPEPDPEPEPEQEPVSEIQEEKPEPVLEETAPEDAQKSSSPAPADIAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NDMEEHLEEPVAEPEPDPEPEPEQEPVSEIQEEKPEPVLEETAPEDAQKSSSPAPADIAQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 TVQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPPQRPQRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPPQRPQRD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 QRVREQRINIPPQRGPRPIREAGEQGDIEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QRVREQRINIPPQRGPRPIREAGEQGDIEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 QSYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAARE 370 380 390 400 410 420 430 440 450 460 pF1KE3 GDRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRGLAPRQ :::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRGLAPRQ 430 440 450 460 >>NP_938405 (OMIM: 608431) ras GTPase-activating protein (466 aa) initn: 3191 init1: 3191 opt: 3191 Z-score: 1757.2 bits: 334.4 E(85289): 3.9e-91 Smith-Waterman score: 3191; 100.0% identity (100.0% similar) in 466 aa overlap (1-466:1-466) 10 20 30 40 50 60 pF1KE3 MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_938 MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 IHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_938 IHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 ANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQAVVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_938 ANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQAVVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 NDMEEHLEEPVAEPEPDPEPEPEQEPVSEIQEEKPEPVLEETAPEDAQKSSSPAPADIAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_938 NDMEEHLEEPVAEPEPDPEPEPEQEPVSEIQEEKPEPVLEETAPEDAQKSSSPAPADIAQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 TVQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPPQRPQRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_938 TVQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPPQRPQRD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 QRVREQRINIPPQRGPRPIREAGEQGDIEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_938 QRVREQRINIPPQRGPRPIREAGEQGDIEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 QSYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_938 QSYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAARE 370 380 390 400 410 420 430 440 450 460 pF1KE3 GDRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRGLAPRQ :::::::::::::::::::::::::::::::::::::::::::::: NP_938 GDRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRGLAPRQ 430 440 450 460 466 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 18 17:34:34 2016 done: Fri Nov 18 17:34:36 2016 Total Scan time: 11.730 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]