Result of FASTA (omim) for
pF1KE4105
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4105, 475 aa
1>>>pF1KE4105 475 - 475 aa - 475 aa
Library: /omim/omim.rfq.tfa
64369986 residues in 92320 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2944+/-0.000396; mu= 19.2440+/- 0.025
mean_var=85.2748+/-17.656, 0's: 0 Z-trim(113.0): 480 B-trim: 10 in 1/51
Lambda= 0.138888
statistics sampled from 22594 (23089) to 22594 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.609), E-opt: 0.2 (0.25), width: 16
Scan time: 4.400
The best scores are: opt bits E(92320)
XP_011509781 (OMIM: 610578) rho GTPase-activating ( 475) 3099 631.2 2.1e-180
NP_060930 (OMIM: 610578) rho GTPase-activating pro ( 475) 3099 631.2 2.1e-180
XP_016859988 (OMIM: 610578) rho GTPase-activating ( 475) 3099 631.2 2.1e-180
XP_016859989 (OMIM: 610578) rho GTPase-activating ( 432) 2773 565.8 8.9e-161
XP_011509783 (OMIM: 610578) rho GTPase-activating ( 435) 2734 558.0 2e-158
XP_011509784 (OMIM: 610578) rho GTPase-activating ( 416) 2723 555.8 9e-158
XP_011509785 (OMIM: 610578) rho GTPase-activating ( 397) 2277 466.4 6.9e-131
XP_011509786 (OMIM: 610578) rho GTPase-activating ( 342) 2187 448.3 1.7e-125
XP_016859990 (OMIM: 610578) rho GTPase-activating ( 341) 2031 417.1 4.3e-116
XP_024308768 (OMIM: 610578) rho GTPase-activating ( 241) 1570 324.5 2.1e-88
XP_024308769 (OMIM: 610578) rho GTPase-activating ( 241) 1570 324.5 2.1e-88
XP_005257185 (OMIM: 610591) rho GTPase-activating ( 667) 1241 259.0 3.1e-68
XP_006721810 (OMIM: 610591) rho GTPase-activating ( 867) 1241 259.1 3.8e-68
NP_954976 (OMIM: 610591) rho GTPase-activating pro ( 548) 1218 254.3 6.6e-67
XP_016879801 (OMIM: 610591) rho GTPase-activating ( 689) 1218 254.4 7.8e-67
NP_001269219 (OMIM: 610591) rho GTPase-activating ( 889) 1218 254.5 9.4e-67
XP_006721808 (OMIM: 610591) rho GTPase-activating ( 889) 1218 254.5 9.4e-67
XP_016872443 (OMIM: 610577) rho GTPase-activating ( 742) 1023 215.4 4.8e-55
NP_001257627 (OMIM: 610577) rho GTPase-activating ( 769) 1023 215.4 4.9e-55
XP_011518063 (OMIM: 610577) rho GTPase-activating ( 772) 1023 215.4 4.9e-55
NP_001257628 (OMIM: 610577) rho GTPase-activating ( 794) 1023 215.4 5e-55
XP_005252701 (OMIM: 610577) rho GTPase-activating ( 794) 1023 215.4 5e-55
NP_001257626 (OMIM: 610577) rho GTPase-activating ( 799) 1023 215.4 5e-55
NP_001257625 (OMIM: 610577) rho GTPase-activating ( 816) 1023 215.4 5.1e-55
NP_001257624 (OMIM: 610577) rho GTPase-activating ( 841) 1023 215.4 5.2e-55
NP_060757 (OMIM: 610577) rho GTPase-activating pro ( 846) 1023 215.4 5.3e-55
XP_011522776 (OMIM: 610591) rho GTPase-activating ( 581) 944 199.5 2.3e-50
XP_011522774 (OMIM: 610591) rho GTPase-activating ( 722) 944 199.5 2.7e-50
XP_011522773 (OMIM: 610591) rho GTPase-activating ( 865) 944 199.6 3.1e-50
XP_011522771 (OMIM: 610591) rho GTPase-activating ( 900) 944 199.6 3.2e-50
XP_016879800 (OMIM: 610591) rho GTPase-activating ( 922) 944 199.6 3.3e-50
XP_011522770 (OMIM: 610591) rho GTPase-activating ( 922) 944 199.6 3.3e-50
NP_001354354 (OMIM: 610576) rho GTPase-activating ( 425) 738 158.1 4.9e-38
NP_001354353 (OMIM: 610576) rho GTPase-activating ( 456) 735 157.5 7.8e-38
XP_011536961 (OMIM: 610576) rho GTPase-activating ( 640) 735 157.6 1e-37
NP_001073626 (OMIM: 610576) rho GTPase-activating ( 640) 735 157.6 1e-37
XP_011522772 (OMIM: 610591) rho GTPase-activating ( 870) 651 140.9 1.5e-32
XP_011523379 (OMIM: 610590) rho GTPase-activating (1117) 539 118.5 1e-25
XP_016880391 (OMIM: 610590) rho GTPase-activating (1119) 539 118.5 1e-25
XP_024306615 (OMIM: 610590) rho GTPase-activating (1144) 539 118.6 1e-25
XP_011523378 (OMIM: 610590) rho GTPase-activating (1159) 539 118.6 1e-25
XP_006722056 (OMIM: 610590) rho GTPase-activating (1249) 539 118.6 1.1e-25
XP_011523377 (OMIM: 610590) rho GTPase-activating (1285) 539 118.6 1.1e-25
XP_011523376 (OMIM: 610590) rho GTPase-activating (1397) 539 118.6 1.2e-25
XP_006722054 (OMIM: 610590) rho GTPase-activating (1473) 539 118.7 1.2e-25
XP_011523375 (OMIM: 610590) rho GTPase-activating (1476) 539 118.7 1.2e-25
NP_001186346 (OMIM: 610590) rho GTPase-activating (1491) 539 118.7 1.2e-25
XP_016872727 (OMIM: 615936) rho GTPase-activating ( 771) 485 107.6 1.4e-22
NP_001354874 (OMIM: 615936) rho GTPase-activating ( 780) 485 107.6 1.4e-22
XP_016872726 (OMIM: 615936) rho GTPase-activating ( 820) 485 107.6 1.5e-22
>>XP_011509781 (OMIM: 610578) rho GTPase-activating prot (475 aa)
initn: 3099 init1: 3099 opt: 3099 Z-score: 3360.5 bits: 631.2 E(92320): 2.1e-180
Smith-Waterman score: 3099; 100.0% identity (100.0% similar) in 475 aa overlap (1-475:1-475)
10 20 30 40 50 60
pF1KE4 MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 RNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 KQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 FHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 SASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 CIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 ELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKA
370 380 390 400 410 420
430 440 450 460 470
pF1KE4 SKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSEED
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSEED
430 440 450 460 470
>>NP_060930 (OMIM: 610578) rho GTPase-activating protein (475 aa)
initn: 3099 init1: 3099 opt: 3099 Z-score: 3360.5 bits: 631.2 E(92320): 2.1e-180
Smith-Waterman score: 3099; 100.0% identity (100.0% similar) in 475 aa overlap (1-475:1-475)
10 20 30 40 50 60
pF1KE4 MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 RNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 RNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 KQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 KQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 FHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 FHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 SASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 CIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 CIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 ELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKA
370 380 390 400 410 420
430 440 450 460 470
pF1KE4 SKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSEED
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSEED
430 440 450 460 470
>>XP_016859988 (OMIM: 610578) rho GTPase-activating prot (475 aa)
initn: 3099 init1: 3099 opt: 3099 Z-score: 3360.5 bits: 631.2 E(92320): 2.1e-180
Smith-Waterman score: 3099; 100.0% identity (100.0% similar) in 475 aa overlap (1-475:1-475)
10 20 30 40 50 60
pF1KE4 MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 RNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 KQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 FHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 SASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 CIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 ELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKA
370 380 390 400 410 420
430 440 450 460 470
pF1KE4 SKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSEED
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSEED
430 440 450 460 470
>>XP_016859989 (OMIM: 610578) rho GTPase-activating prot (432 aa)
initn: 2773 init1: 2773 opt: 2773 Z-score: 3008.1 bits: 565.8 E(92320): 8.9e-161
Smith-Waterman score: 2773; 97.9% identity (98.8% similar) in 432 aa overlap (44-475:1-432)
20 30 40 50 60 70
pF1KE4 LNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHRRNHSQHILKDVIP
: .. .:. : ::::::::::::::::::
XP_016 MAVSITGHCREKISRHRRNHSQHILKDVIP
10 20 30
80 90 100 110 120 130
pF1KE4 PLEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHK
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE4 PESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDWFHAIKNAIDRLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDWFHAIKNAIDRLPK
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE4 DSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKS
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE4 RLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVD
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE4 GIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFE
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE4 QFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIV
340 350 360 370 380 390
440 450 460 470
pF1KE4 FGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSEED
::::::::::::::::::::::::::::::::::::::::::
XP_016 FGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSEED
400 410 420 430
>>XP_011509783 (OMIM: 610578) rho GTPase-activating prot (435 aa)
initn: 2734 init1: 2734 opt: 2734 Z-score: 2965.8 bits: 558.0 E(92320): 2e-158
Smith-Waterman score: 2734; 100.0% identity (100.0% similar) in 416 aa overlap (1-416:1-416)
10 20 30 40 50 60
pF1KE4 MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 RNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 KQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 FHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 SASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 CIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 ELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIQTHH
370 380 390 400 410 420
430 440 450 460 470
pF1KE4 SKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSEED
XP_011 ESGFKLQLLMLPGIN
430
>>XP_011509784 (OMIM: 610578) rho GTPase-activating prot (416 aa)
initn: 2723 init1: 2723 opt: 2723 Z-score: 2954.1 bits: 555.8 E(92320): 9e-158
Smith-Waterman score: 2723; 100.0% identity (100.0% similar) in 414 aa overlap (1-414:1-414)
10 20 30 40 50 60
pF1KE4 MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 RNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 KQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 FHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 SASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 CIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 ELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTNC
370 380 390 400 410
430 440 450 460 470
pF1KE4 SKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSEED
>>XP_011509785 (OMIM: 610578) rho GTPase-activating prot (397 aa)
initn: 2277 init1: 2277 opt: 2277 Z-score: 2471.4 bits: 466.4 E(92320): 6.9e-131
Smith-Waterman score: 2277; 100.0% identity (100.0% similar) in 347 aa overlap (129-475:51-397)
100 110 120 130 140 150
pF1KE4 RKNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQ
::::::::::::::::::::::::::::::
XP_011 HWAVEPAAAGAFLYVRCFSCPAWHHWPLSPKTGHKPESVDLCGAHIEWAKEKSSRKNVFQ
30 40 50 60 70 80
160 170 180 190 200 210
pF1KE4 ITTVSGNEFLLQSDIDFIILDWFHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITTVSGNEFLLQSDIDFIILDWFHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSH
90 100 110 120 130 140
220 230 240 250 260 270
pF1KE4 YDSDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YDSDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQI
150 160 170 180 190 200
280 290 300 310 320 330
pF1KE4 FGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKL
210 220 230 240 250 260
340 350 360 370 380 390
pF1KE4 NLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKL
270 280 290 300 310 320
400 410 420 430 440 450
pF1KE4 PPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQI
330 340 350 360 370 380
460 470
pF1KE4 AELMLSEYSKIFGSEED
:::::::::::::::::
XP_011 AELMLSEYSKIFGSEED
390
>>XP_011509786 (OMIM: 610578) rho GTPase-activating prot (342 aa)
initn: 2187 init1: 2187 opt: 2187 Z-score: 2374.8 bits: 448.3 E(92320): 1.7e-125
Smith-Waterman score: 2187; 100.0% identity (100.0% similar) in 334 aa overlap (1-334:1-334)
10 20 30 40 50 60
pF1KE4 MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 RNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 KQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 FHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 SASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 CIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFR
::::::::::::::::::::::::::::::::::
XP_011 CIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQAPAPPSLT
310 320 330 340
370 380 390 400 410 420
pF1KE4 ELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKA
>>XP_016859990 (OMIM: 610578) rho GTPase-activating prot (341 aa)
initn: 2031 init1: 2031 opt: 2031 Z-score: 2205.9 bits: 417.1 E(92320): 4.3e-116
Smith-Waterman score: 2031; 100.0% identity (100.0% similar) in 309 aa overlap (1-309:1-309)
10 20 30 40 50 60
pF1KE4 MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 RNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 KQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 FHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 SASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 CIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFR
:::::::::
XP_016 CIEAVEKRGNMINVGRTLKPRKQEKTCEPVHLISHGAKYGN
310 320 330 340
>>XP_024308768 (OMIM: 610578) rho GTPase-activating prot (241 aa)
initn: 1570 init1: 1570 opt: 1570 Z-score: 1708.7 bits: 324.5 E(92320): 2.1e-88
Smith-Waterman score: 1570; 100.0% identity (100.0% similar) in 241 aa overlap (235-475:1-241)
210 220 230 240 250 260
pF1KE4 FKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKSRLKKFITRRPS
::::::::::::::::::::::::::::::
XP_024 MFRLHHSASDTSDKNRVKSRLKKFITRRPS
10 20 30
270 280 290 300 310 320
pF1KE4 LKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 LKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLAT
40 50 60 70 80 90
330 340 350 360 370 380
pF1KE4 IQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 IQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDN
100 110 120 130 140 150
390 400 410 420 430 440
pF1KE4 NTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 NTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENE
160 170 180 190 200 210
450 460 470
pF1KE4 TGNMAIHMVYQNQIAELMLSEYSKIFGSEED
:::::::::::::::::::::::::::::::
XP_024 TGNMAIHMVYQNQIAELMLSEYSKIFGSEED
220 230 240
475 residues in 1 query sequences
64369986 residues in 92320 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Oct 24 21:37:42 2019 done: Thu Oct 24 21:37:43 2019
Total Scan time: 4.400 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]