FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4294, 2015 aa 1>>>pF1KE4294 2015 - 2015 aa - 2015 aa Library: human.CCDS.faa 18921897 residues in 33420 sequences Statistics: Expectation_n fit: rho(ln(x))= 13.6074+/-0.00149; mu= -16.2231+/- 0.086 mean_var=571.1714+/-126.371, 0's: 0 Z-trim(107.6): 342 B-trim: 0 in 0/53 Lambda= 0.053665 statistics sampled from 9488 (9786) to 9488 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.632), E-opt: 0.2 (0.293), width: 16 Scan time: 3.370 The best scores are: opt bits E(33420) CCDS42086.1 LRRK1 gene_id:79705|Hs109|chr15 (2015) 13560 1067.6 0 >>CCDS42086.1 LRRK1 gene_id:79705|Hs109|chr15 (2015 aa) initn: 13560 init1: 13560 opt: 13560 Z-score: 5696.9 bits: 1067.6 E(33420): 0 Smith-Waterman score: 13560; 100.0% identity (100.0% similar) in 2015 aa overlap (1-2015:1-2015) 10 20 30 40 50 60 pF1KE4 MAGMSQRPPSMYWCVGPEESAVCPERAMETLNGAGDTGGKPSTRGGDPAARSRRTEGIRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 MAGMSQRPPSMYWCVGPEESAVCPERAMETLNGAGDTGGKPSTRGGDPAARSRRTEGIRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 AYRRGDRGGARDLLEEACDQCASQLEKGQLLSIPAAYGDLEMVRYLLSKRLVELPTEPTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 AYRRGDRGGARDLLEEACDQCASQLEKGQLLSIPAAYGDLEMVRYLLSKRLVELPTEPTD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DNPAVVAAYFGHTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 DNPAVVAAYFGHTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 ESYAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 ESYAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 IEASPLPSSYPGKTALRVKWSHLRLPWVDLDWLIDISCQITELDLSANCLATLPSVIPWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 IEASPLPSSYPGKTALRVKWSHLRLPWVDLDWLIDISCQITELDLSANCLATLPSVIPWG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 LINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTAS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 KNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 KNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 DPWACPLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 DPWACPLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 QGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 QGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 EFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 EFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 DTEDLTISNVPAEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 DTEDLTISNVPAEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 GRAPQVVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 GRAPQVVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALY 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE4 VVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 VVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE4 LCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAG 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE4 RLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 RLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE4 IETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 IETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVG 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE4 TGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 TGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKM 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE4 SFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 SFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKR 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE4 NQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 NQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSL 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE4 IDQWFPALTATESDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 IDQWFPALTATESDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIER 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE4 DFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 DFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRA 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE4 RYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 RYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIV 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE4 ALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 ALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKK 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE4 NIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 NIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIV 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KE4 YDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 YDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMM 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KE4 ECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 ECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESR 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KE4 NYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 NYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQA 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 pF1KE4 LDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFS 1630 1640 1650 1660 1670 1680 1690 1700 1710 1720 1730 1740 pF1KE4 IADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 IADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVV 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 pF1KE4 CSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 CSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAAS 1750 1760 1770 1780 1790 1800 1810 1820 1830 1840 1850 1860 pF1KE4 HTANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 HTANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLP 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 1910 1920 pF1KE4 SSPASSSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 SSPASSSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIW 1870 1880 1890 1900 1910 1920 1930 1940 1950 1960 1970 1980 pF1KE4 VPRRGGDVIVIGLEKDSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 VPRRGGDVIVIGLEKDSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTE 1930 1940 1950 1960 1970 1980 1990 2000 2010 pF1KE4 WCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR ::::::::::::::::::::::::::::::::::: CCDS42 WCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR 1990 2000 2010 2015 residues in 1 query sequences 18921897 residues in 33420 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Jul 16 15:53:53 2019 done: Tue Jul 16 15:53:53 2019 Total Scan time: 3.370 Total Display time: 0.100 Function used was FASTA [36.3.4 Apr, 2011]