Result of FASTA (omim) for
pF1KE4294
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4294, 2015 aa
1>>>pF1KE4294 2015 - 2015 aa - 2015 aa
Library: /omim/omim.rfq.tfa
64092750 residues in 91774 sequences
Statistics: Expectation_n fit: rho(ln(x))= 14.2802+/-0.000666; mu= -17.2117+/- 0.041
mean_var=1035.2046+/-233.013, 0's: 0 Z-trim(115.9): 264 B-trim: 0 in 0/56
Lambda= 0.039862
statistics sampled from 27549 (27703) to 27549 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.633), E-opt: 0.2 (0.302), width: 16
Scan time: 10.720
The best scores are: opt bits E(91774)
XP_011520314 (OMIM: 610986) leucine-rich repeat se (2015) 13560 799.1 0
NP_078928 (OMIM: 610986) leucine-rich repeat serin (2015) 13560 799.1 0
XP_011520315 (OMIM: 610986) leucine-rich repeat se (2015) 13560 799.1 0
XP_011520316 (OMIM: 610986) leucine-rich repeat se (1981) 12945 763.7 0
XP_011520318 (OMIM: 610986) leucine-rich repeat se (1914) 12858 758.7 1.5e-217
XP_011520317 (OMIM: 610986) leucine-rich repeat se (1767) 11834 699.7 7.5e-200
XP_016878059 (OMIM: 610986) leucine-rich repeat se (1524) 10087 599.2 1.2e-169
XP_011520319 (OMIM: 610986) leucine-rich repeat se (1310) 8811 525.7 1.4e-147
XP_005255036 (OMIM: 610986) leucine-rich repeat se (1310) 8811 525.7 1.4e-147
XP_011520320 (OMIM: 610986) leucine-rich repeat se (1310) 8811 525.7 1.4e-147
XP_011520321 (OMIM: 610986) leucine-rich repeat se (1086) 6999 421.4 2.9e-116
>>XP_011520314 (OMIM: 610986) leucine-rich repeat serine (2015 aa)
initn: 13560 init1: 13560 opt: 13560 Z-score: 4245.4 bits: 799.1 E(91774): 0
Smith-Waterman score: 13560; 100.0% identity (100.0% similar) in 2015 aa overlap (1-2015:1-2015)
10 20 30 40 50 60
pF1KE4 MAGMSQRPPSMYWCVGPEESAVCPERAMETLNGAGDTGGKPSTRGGDPAARSRRTEGIRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAGMSQRPPSMYWCVGPEESAVCPERAMETLNGAGDTGGKPSTRGGDPAARSRRTEGIRA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 AYRRGDRGGARDLLEEACDQCASQLEKGQLLSIPAAYGDLEMVRYLLSKRLVELPTEPTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AYRRGDRGGARDLLEEACDQCASQLEKGQLLSIPAAYGDLEMVRYLLSKRLVELPTEPTD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DNPAVVAAYFGHTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNPAVVAAYFGHTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 ESYAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESYAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 IEASPLPSSYPGKTALRVKWSHLRLPWVDLDWLIDISCQITELDLSANCLATLPSVIPWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IEASPLPSSYPGKTALRVKWSHLRLPWVDLDWLIDISCQITELDLSANCLATLPSVIPWG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 LINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTAS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 KNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 DPWACPLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DPWACPLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 QGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 EFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 DTEDLTISNVPAEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DTEDLTISNVPAEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 GRAPQVVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRAPQVVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALY
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 VVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE4 LCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE4 RLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE4 IETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE4 TGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKM
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE4 SFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKR
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE4 NQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSL
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE4 IDQWFPALTATESDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDQWFPALTATESDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIER
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE4 DFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRA
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE4 RYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIV
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE4 ALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKK
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE4 NIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIV
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE4 YDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMM
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE4 ECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESR
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE4 NYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQA
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE4 LDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFS
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE4 IADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVV
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE4 CSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAAS
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE4 HTANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HTANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLP
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE4 SSPASSSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSPASSSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIW
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE4 VPRRGGDVIVIGLEKDSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPRRGGDVIVIGLEKDSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTE
1930 1940 1950 1960 1970 1980
1990 2000 2010
pF1KE4 WCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR
:::::::::::::::::::::::::::::::::::
XP_011 WCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR
1990 2000 2010
>>NP_078928 (OMIM: 610986) leucine-rich repeat serine/th (2015 aa)
initn: 13560 init1: 13560 opt: 13560 Z-score: 4245.4 bits: 799.1 E(91774): 0
Smith-Waterman score: 13560; 100.0% identity (100.0% similar) in 2015 aa overlap (1-2015:1-2015)
10 20 30 40 50 60
pF1KE4 MAGMSQRPPSMYWCVGPEESAVCPERAMETLNGAGDTGGKPSTRGGDPAARSRRTEGIRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 MAGMSQRPPSMYWCVGPEESAVCPERAMETLNGAGDTGGKPSTRGGDPAARSRRTEGIRA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 AYRRGDRGGARDLLEEACDQCASQLEKGQLLSIPAAYGDLEMVRYLLSKRLVELPTEPTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 AYRRGDRGGARDLLEEACDQCASQLEKGQLLSIPAAYGDLEMVRYLLSKRLVELPTEPTD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DNPAVVAAYFGHTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 DNPAVVAAYFGHTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 ESYAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 ESYAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 IEASPLPSSYPGKTALRVKWSHLRLPWVDLDWLIDISCQITELDLSANCLATLPSVIPWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 IEASPLPSSYPGKTALRVKWSHLRLPWVDLDWLIDISCQITELDLSANCLATLPSVIPWG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 LINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 LINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTAS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 KNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 KNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 DPWACPLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 DPWACPLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 QGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 QGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 EFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 EFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 DTEDLTISNVPAEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 DTEDLTISNVPAEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 GRAPQVVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 GRAPQVVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALY
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 VVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 VVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE4 LCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 LCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE4 RLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 RLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE4 IETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 IETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE4 TGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 TGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKM
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE4 SFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 SFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKR
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE4 NQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 NQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSL
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE4 IDQWFPALTATESDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 IDQWFPALTATESDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIER
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE4 DFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 DFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRA
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE4 RYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 RYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIV
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE4 ALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 ALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKK
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE4 NIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 NIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIV
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE4 YDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 YDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMM
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE4 ECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 ECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESR
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE4 NYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 NYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQA
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE4 LDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 LDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFS
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE4 IADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 IADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVV
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE4 CSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 CSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAAS
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE4 HTANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 HTANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLP
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE4 SSPASSSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 SSPASSSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIW
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE4 VPRRGGDVIVIGLEKDSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 VPRRGGDVIVIGLEKDSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTE
1930 1940 1950 1960 1970 1980
1990 2000 2010
pF1KE4 WCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR
:::::::::::::::::::::::::::::::::::
NP_078 WCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR
1990 2000 2010
>>XP_011520315 (OMIM: 610986) leucine-rich repeat serine (2015 aa)
initn: 13560 init1: 13560 opt: 13560 Z-score: 4245.4 bits: 799.1 E(91774): 0
Smith-Waterman score: 13560; 100.0% identity (100.0% similar) in 2015 aa overlap (1-2015:1-2015)
10 20 30 40 50 60
pF1KE4 MAGMSQRPPSMYWCVGPEESAVCPERAMETLNGAGDTGGKPSTRGGDPAARSRRTEGIRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAGMSQRPPSMYWCVGPEESAVCPERAMETLNGAGDTGGKPSTRGGDPAARSRRTEGIRA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 AYRRGDRGGARDLLEEACDQCASQLEKGQLLSIPAAYGDLEMVRYLLSKRLVELPTEPTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AYRRGDRGGARDLLEEACDQCASQLEKGQLLSIPAAYGDLEMVRYLLSKRLVELPTEPTD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DNPAVVAAYFGHTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNPAVVAAYFGHTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 ESYAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESYAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 IEASPLPSSYPGKTALRVKWSHLRLPWVDLDWLIDISCQITELDLSANCLATLPSVIPWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IEASPLPSSYPGKTALRVKWSHLRLPWVDLDWLIDISCQITELDLSANCLATLPSVIPWG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 LINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTAS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 KNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 DPWACPLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DPWACPLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 QGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 EFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 DTEDLTISNVPAEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DTEDLTISNVPAEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 GRAPQVVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRAPQVVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALY
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 VVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE4 LCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE4 RLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE4 IETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE4 TGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKM
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE4 SFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKR
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE4 NQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSL
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE4 IDQWFPALTATESDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDQWFPALTATESDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIER
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE4 DFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRA
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE4 RYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIV
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE4 ALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKK
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE4 NIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIV
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE4 YDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMM
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE4 ECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESR
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE4 NYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQA
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE4 LDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFS
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE4 IADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVV
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE4 CSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAAS
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE4 HTANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HTANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLP
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE4 SSPASSSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSPASSSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIW
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE4 VPRRGGDVIVIGLEKDSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPRRGGDVIVIGLEKDSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTE
1930 1940 1950 1960 1970 1980
1990 2000 2010
pF1KE4 WCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR
:::::::::::::::::::::::::::::::::::
XP_011 WCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR
1990 2000 2010
>>XP_011520316 (OMIM: 610986) leucine-rich repeat serine (1981 aa)
initn: 13328 init1: 12938 opt: 12945 Z-score: 4054.4 bits: 763.7 E(91774): 0
Smith-Waterman score: 13264; 98.3% identity (98.3% similar) in 2015 aa overlap (1-2015:1-1981)
10 20 30 40 50 60
pF1KE4 MAGMSQRPPSMYWCVGPEESAVCPERAMETLNGAGDTGGKPSTRGGDPAARSRRTEGIRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAGMSQRPPSMYWCVGPEESAVCPERAMETLNGAGDTGGKPSTRGGDPAARSRRTEGIRA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 AYRRGDRGGARDLLEEACDQCASQLEKGQLLSIPAAYGDLEMVRYLLSKRLVELPTEPTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AYRRGDRGGARDLLEEACDQCASQLEKGQLLSIPAAYGDLEMVRYLLSKRLVELPTEPTD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DNPAVVAAYFGHTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNPAVVAAYFGHTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 ESYAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESYAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 IEASPLPSSYPGKTALRVKWSHLRLPWVDLDWLIDISCQITELDLSANCLATLPSVIPWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IEASPLPSSYPGKTALRVKWSHLRLPWVDLDWLIDISCQITELDLSANCLATLPSVIPWG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 LINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTAS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 KNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 DPWACPLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DPWACPLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 QGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 EFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 DTEDLTISNVPAEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DTEDLTISNVPAEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 GRAPQVVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRAPQVVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALY
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 VVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE4 LCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE4 RLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE4 IETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE4 TGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKM
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE4 SFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKR
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE4 NQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSL
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE4 IDQWFPALTATESDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDQWFPALTATESDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIER
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE4 DFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRA
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE4 RYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIV
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE4 ALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKK
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE4 NIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIV
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE4 YDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMM
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE4 ECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESR
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE4 NYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQA
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE4 LDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFS
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE4 IADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVV
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE4 CSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAAS
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE4 HTANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HTANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLP
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE4 SSPASSSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSPASSSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIW
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE4 VPRRGGDVIVIGLEKDSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTE
::: :::::::::::::::::::::::
XP_011 VPR----------------------------------VLVDAAVVAKDTVVCTFENENTE
1930 1940
1990 2000 2010
pF1KE4 WCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR
:::::::::::::::::::::::::::::::::::
XP_011 WCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR
1950 1960 1970 1980
>>XP_011520318 (OMIM: 610986) leucine-rich repeat serine (1914 aa)
initn: 12858 init1: 12858 opt: 12858 Z-score: 4027.5 bits: 758.7 E(91774): 1.5e-217
Smith-Waterman score: 12858; 100.0% identity (100.0% similar) in 1914 aa overlap (102-2015:1-1914)
80 90 100 110 120 130
pF1KE4 DLLEEACDQCASQLEKGQLLSIPAAYGDLEMVRYLLSKRLVELPTEPTDDNPAVVAAYFG
::::::::::::::::::::::::::::::
XP_011 MVRYLLSKRLVELPTEPTDDNPAVVAAYFG
10 20 30
140 150 160 170 180 190
pF1KE4 HTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADPESYAVRKNEFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADPESYAVRKNEFP
40 50 60 70 80 90
200 210 220 230 240 250
pF1KE4 VIVRLPLYAAIKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYFIEASPLPSSYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIVRLPLYAAIKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYFIEASPLPSSYP
100 110 120 130 140 150
260 270 280 290 300 310
pF1KE4 GKTALRVKWSHLRLPWVDLDWLIDISCQITELDLSANCLATLPSVIPWGLINLRKLNLSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKTALRVKWSHLRLPWVDLDWLIDISCQITELDLSANCLATLPSVIPWGLINLRKLNLSD
160 170 180 190 200 210
320 330 340 350 360 370
pF1KE4 NHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTASKNCLEKLFEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTASKNCLEKLFEEE
220 230 240 250 260 270
380 390 400 410 420 430
pF1KE4 NATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPDPWACPLKCCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPDPWACPLKCCK
280 290 300 310 320 330
440 450 460 470 480 490
pF1KE4 ASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQ
340 350 360 370 380 390
500 510 520 530 540 550
pF1KE4 EKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLSESLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLSESLE
400 410 420 430 440 450
560 570 580 590 600 610
pF1KE4 VLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVP
460 470 480 490 500 510
620 630 640 650 660 670
pF1KE4 AEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQTGRAPQVVHGEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQTGRAPQVVHGEA
520 530 540 550 560 570
680 690 700 710 720 730
pF1KE4 TIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGEE
580 590 600 610 620 630
740 750 760 770 780 790
pF1KE4 AVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRAT
640 650 660 670 680 690
800 810 820 830 840 850
pF1KE4 GFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAGRLIPRSYLSLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAGRLIPRSYLSLQ
700 710 720 730 740 750
860 870 880 890 900 910
pF1KE4 EAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFLIETGTLLHFPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFLIETGTLLHFPD
760 770 780 790 800 810
920 930 940 950 960 970
pF1KE4 TSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGTGFTQQTEEQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGTGFTQQTEEQY
820 830 840 850 860 870
980 990 1000 1010 1020 1030
pF1KE4 FQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKMSFVPVGFWQRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKMSFVPVGFWQRF
880 890 900 910 920 930
1040 1050 1060 1070 1080 1090
pF1KE4 IARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKRNQTIYWQEGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKRNQTIYWQEGLL
940 950 960 970 980 990
1100 1110 1120 1130 1140 1150
pF1KE4 VTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSLIDQWFPALTAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSLIDQWFPALTAT
1000 1010 1020 1030 1040 1050
1160 1170 1180 1190 1200 1210
pF1KE4 ESDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIERDFISCPRHPDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIERDFISCPRHPDL
1060 1070 1080 1090 1100 1110
1220 1230 1240 1250 1260 1270
pF1KE4 PVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRARYQGQPVAVKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRARYQGQPVAVKR
1120 1130 1140 1150 1160 1170
1280 1290 1300 1310 1320 1330
pF1KE4 FHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISIHPLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISIHPLC
1180 1190 1200 1210 1220 1230
1340 1350 1360 1370 1380 1390
pF1KE4 FALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDN
1240 1250 1260 1270 1280 1290
1400 1410 1420 1430 1440 1450
pF1KE4 ILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYG
1300 1310 1320 1330 1340 1350
1460 1470 1480 1490 1500 1510
pF1KE4 MVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRP
1360 1370 1380 1390 1400 1410
1520 1530 1540 1550 1560 1570
pF1KE4 LALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESRNYTVVNTEKGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESRNYTVVNTEKGL
1420 1430 1440 1450 1460 1470
1580 1590 1600 1610 1620 1630
pF1KE4 MEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQALDTPAVVTCFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQALDTPAVVTCFL
1480 1490 1500 1510 1520 1530
1640 1650 1660 1670 1680 1690
pF1KE4 AVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFSIADEDARQNPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFSIADEDARQNPY
1540 1550 1560 1570 1580 1590
1700 1710 1720 1730 1740 1750
pF1KE4 PVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVVCSSEGRGEEVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVVCSSEGRGEEVV
1600 1610 1620 1630 1640 1650
1760 1770 1780 1790 1800 1810
pF1KE4 WCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAASHTANPKVPEGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAASHTANPKVPEGD
1660 1670 1680 1690 1700 1710
1820 1830 1840 1850 1860 1870
pF1KE4 SIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLPSSPASSSSVPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLPSSPASSSSVPF
1720 1730 1740 1750 1760 1770
1880 1890 1900 1910 1920 1930
pF1KE4 STDCEDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIWVPRRGGDVIVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STDCEDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIWVPRRGGDVIVI
1780 1790 1800 1810 1820 1830
1940 1950 1960 1970 1980 1990
pF1KE4 GLEKDSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTEWCLAVWRGWGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLEKDSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTEWCLAVWRGWGA
1840 1850 1860 1870 1880 1890
2000 2010
pF1KE4 REFDIFYQSYEELGRLEACTRKRR
::::::::::::::::::::::::
XP_011 REFDIFYQSYEELGRLEACTRKRR
1900 1910
>>XP_011520317 (OMIM: 610986) leucine-rich repeat serine (1767 aa)
initn: 11834 init1: 11834 opt: 11834 Z-score: 3709.6 bits: 699.7 E(91774): 7.5e-200
Smith-Waterman score: 11834; 100.0% identity (100.0% similar) in 1761 aa overlap (255-2015:7-1767)
230 240 250 260 270 280
pF1KE4 LLDSPDPSKHLLRKYFIEASPLPSSYPGKTALRVKWSHLRLPWVDLDWLIDISCQITELD
::::::::::::::::::::::::::::::
XP_011 MTQEPEALRVKWSHLRLPWVDLDWLIDISCQITELD
10 20 30
290 300 310 320 330 340
pF1KE4 LSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHL
40 50 60 70 80 90
350 360 370 380 390 400
pF1KE4 PPGFLHLSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALFLHSFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPGFLHLSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALFLHSFK
100 110 120 130 140 150
410 420 430 440 450 460
pF1KE4 SLNSLNVSRNNLKVFPDPWACPLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLNSLNVSRNNLKVFPDPWACPLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKE
160 170 180 190 200 210
470 480 490 500 510 520
pF1KE4 VPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFF
220 230 240 250 260 270
530 540 550 560 570 580
pF1KE4 TTRGRQRSGTEAASVLEFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTRGRQRSGTEAASVLEFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGL
280 290 300 310 320 330
590 600 610 620 630 640
pF1KE4 RELPPELGQLGNLWQLDTEDLTISNVPAEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RELPPELGQLGNLWQLDTEDLTISNVPAEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIV
340 350 360 370 380 390
650 660 670 680 690 700
pF1KE4 GPPRQGKSTLLEILQTGRAPQVVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPPRQGKSTLLEILQTGRAPQVVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPA
400 410 420 430 440 450
710 720 730 740 750 760
pF1KE4 SMATVNQCFFTDKALYVVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SMATVNQCFFTDKALYVVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEA
460 470 480 490 500 510
770 780 790 800 810 820
pF1KE4 KFRVERIATLRAYVLALCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KFRVERIATLRAYVLALCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTC
520 530 540 550 560 570
830 840 850 860 870 880
pF1KE4 SMKDVGSTIGCQRLAGRLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SMKDVGSTIGCQRLAGRLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPD
580 590 600 610 620 630
890 900 910 920 930 940
pF1KE4 NDIKDYEDLQSAISFLIETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NDIKDYEDLQSAISFLIETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVA
640 650 660 670 680 690
950 960 970 980 990 1000
pF1KE4 KNGVIRAEDLRMLLVGTGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNGVIRAEDLRMLLVGTGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTH
700 710 720 730 740 750
1010 1020 1030 1040 1050 1060
pF1KE4 GMRHPTANTIQRVFKMSFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GMRHPTANTIQRVFKMSFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYS
760 770 780 790 800 810
1070 1080 1090 1100 1110 1120
pF1KE4 FTGNQRNRCSTFRVKRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FTGNQRNRCSTFRVKRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEV
820 830 840 850 860 870
1130 1140 1150 1160 1170 1180
pF1KE4 RDFSAMAFITDHVNSLIDQWFPALTATESDGTPLMEQYVPCPVCETAWAQHTDPSEKSED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDFSAMAFITDHVNSLIDQWFPALTATESDGTPLMEQYVPCPVCETAWAQHTDPSEKSED
880 890 900 910 920 930
1190 1200 1210 1220 1230 1240
pF1KE4 VQYFDMEDCVLTAIERDFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQYFDMEDCVLTAIERDFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDE
940 950 960 970 980 990
1250 1260 1270 1280 1290 1300
pF1KE4 GSVLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSVLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEF
1000 1010 1020 1030 1040 1050
1310 1320 1330 1340 1350 1360
pF1KE4 RQEASMLHALQHPCIVALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQEASMLHALQHPCIVALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQ
1060 1070 1080 1090 1100 1110
1370 1380 1390 1400 1410 1420
pF1KE4 KIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGV
1120 1130 1140 1150 1160 1170
1430 1440 1450 1460 1470 1480
pF1KE4 EGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVL
1180 1190 1200 1210 1220 1230
1490 1500 1510 1520 1530 1540
pF1KE4 GQPEEVQFRRLQALMMECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQPEEVQFRRLQALMMECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQ
1240 1250 1260 1270 1280 1290
1550 1560 1570 1580 1590 1600
pF1KE4 GQEYTVVFWDGKEESRNYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQEYTVVFWDGKEESRNYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIY
1300 1310 1320 1330 1340 1350
1610 1620 1630 1640 1650 1660
pF1KE4 IYTLKGMCPLNTPQQALDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IYTLKGMCPLNTPQQALDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKD
1360 1370 1380 1390 1400 1410
1670 1680 1690 1700 1710 1720
pF1KE4 SCSYLCSHTANRSKFSIADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SCSYLCSHTANRSKFSIADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEIC
1420 1430 1440 1450 1460 1470
1730 1740 1750 1760 1770 1780
pF1KE4 RRLEPYMAPSMVTSVVCSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRLEPYMAPSMVTSVVCSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLR
1480 1490 1500 1510 1520 1530
1790 1800 1810 1820 1830 1840
pF1KE4 DMFPVRPLDTEPPAASHTANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DMFPVRPLDTEPPAASHTANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSY
1540 1550 1560 1570 1580 1590
1850 1860 1870 1880 1890 1900
pF1KE4 SSSPPRQAARSPSSLPSSPASSSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDGETFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSPPRQAARSPSSLPSSPASSSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDGETFS
1600 1610 1620 1630 1640 1650
1910 1920 1930 1940 1950 1960
pF1KE4 QHLQAVKILAVRDLIWVPRRGGDVIVIGLEKDSGAQRGRVIAVLKARELTPHGVLVDAAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QHLQAVKILAVRDLIWVPRRGGDVIVIGLEKDSGAQRGRVIAVLKARELTPHGVLVDAAV
1660 1670 1680 1690 1700 1710
1970 1980 1990 2000 2010
pF1KE4 VAKDTVVCTFENENTEWCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VAKDTVVCTFENENTEWCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR
1720 1730 1740 1750 1760
>>XP_016878059 (OMIM: 610986) leucine-rich repeat serine (1524 aa)
initn: 10087 init1: 10087 opt: 10087 Z-score: 3167.2 bits: 599.2 E(91774): 1.2e-169
Smith-Waterman score: 10087; 100.0% identity (100.0% similar) in 1504 aa overlap (512-2015:21-1524)
490 500 510 520 530 540
pF1KE4 GNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVLE
::::::::::::::::::::::::::::::
XP_016 MWISQKTHSKKFPWDFSSLINEDGLKTKRIAFFTTRGRQRSGTEAASVLE
10 20 30 40 50
550 560 570 580 590 600
pF1KE4 FPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLD
60 70 80 90 100 110
610 620 630 640 650 660
pF1KE4 TEDLTISNVPAEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEDLTISNVPAEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQTG
120 130 140 150 160 170
670 680 690 700 710 720
pF1KE4 RAPQVVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAPQVVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALYV
180 190 200 210 220 230
730 740 750 760 770 780
pF1KE4 VVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLAL
240 250 260 270 280 290
790 800 810 820 830 840
pF1KE4 CRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAGR
300 310 320 330 340 350
850 860 870 880 890 900
pF1KE4 LIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFLI
360 370 380 390 400 410
910 920 930 940 950 960
pF1KE4 ETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGT
420 430 440 450 460 470
970 980 990 1000 1010 1020
pF1KE4 GFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKMS
480 490 500 510 520 530
1030 1040 1050 1060 1070 1080
pF1KE4 FVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKRN
540 550 560 570 580 590
1090 1100 1110 1120 1130 1140
pF1KE4 QTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSLI
600 610 620 630 640 650
1150 1160 1170 1180 1190 1200
pF1KE4 DQWFPALTATESDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIERD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DQWFPALTATESDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIERD
660 670 680 690 700 710
1210 1220 1230 1240 1250 1260
pF1KE4 FISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRAR
720 730 740 750 760 770
1270 1280 1290 1300 1310 1320
pF1KE4 YQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVA
780 790 800 810 820 830
1330 1340 1350 1360 1370 1380
pF1KE4 LIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKN
840 850 860 870 880 890
1390 1400 1410 1420 1430 1440
pF1KE4 IIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVY
900 910 920 930 940 950
1450 1460 1470 1480 1490 1500
pF1KE4 DEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMME
960 970 980 990 1000 1010
1510 1520 1530 1540 1550 1560
pF1KE4 CWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESRN
1020 1030 1040 1050 1060 1070
1570 1580 1590 1600 1610 1620
pF1KE4 YTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQAL
1080 1090 1100 1110 1120 1130
1630 1640 1650 1660 1670 1680
pF1KE4 DTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFSI
1140 1150 1160 1170 1180 1190
1690 1700 1710 1720 1730 1740
pF1KE4 ADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVVC
1200 1210 1220 1230 1240 1250
1750 1760 1770 1780 1790 1800
pF1KE4 SSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAASH
1260 1270 1280 1290 1300 1310
1810 1820 1830 1840 1850 1860
pF1KE4 TANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLPS
1320 1330 1340 1350 1360 1370
1870 1880 1890 1900 1910 1920
pF1KE4 SPASSSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPASSSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIWV
1380 1390 1400 1410 1420 1430
1930 1940 1950 1960 1970 1980
pF1KE4 PRRGGDVIVIGLEKDSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRRGGDVIVIGLEKDSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTEW
1440 1450 1460 1470 1480 1490
1990 2000 2010
pF1KE4 CLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR
::::::::::::::::::::::::::::::::::
XP_016 CLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR
1500 1510 1520
>>XP_011520319 (OMIM: 610986) leucine-rich repeat serine (1310 aa)
initn: 8811 init1: 8811 opt: 8811 Z-score: 2771.3 bits: 525.7 E(91774): 1.4e-147
Smith-Waterman score: 8811; 100.0% identity (100.0% similar) in 1310 aa overlap (706-2015:1-1310)
680 690 700 710 720 730
pF1KE4 TKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGEEAVAN
::::::::::::::::::::::::::::::
XP_011 MATVNQCFFTDKALYVVVWNLALGEEAVAN
10 20 30
740 750 760 770 780 790
pF1KE4 LQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATGFPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATGFPD
40 50 60 70 80 90
800 810 820 830 840 850
pF1KE4 ITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAGRLIPRSYLSLQEAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAGRLIPRSYLSLQEAVL
100 110 120 130 140 150
860 870 880 890 900 910
pF1KE4 AEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFLIETGTLLHFPDTSHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFLIETGTLLHFPDTSHG
160 170 180 190 200 210
920 930 940 950 960 970
pF1KE4 LRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGTGFTQQTEEQYFQFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGTGFTQQTEEQYFQFL
220 230 240 250 260 270
980 990 1000 1010 1020 1030
pF1KE4 AKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKMSFVPVGFWQRFIARM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKMSFVPVGFWQRFIARM
280 290 300 310 320 330
1040 1050 1060 1070 1080 1090
pF1KE4 LISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKRNQTIYWQEGLLVTFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKRNQTIYWQEGLLVTFD
340 350 360 370 380 390
1100 1110 1120 1130 1140 1150
pF1KE4 GGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSLIDQWFPALTATESDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSLIDQWFPALTATESDG
400 410 420 430 440 450
1160 1170 1180 1190 1200 1210
pF1KE4 TPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIERDFISCPRHPDLPVPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIERDFISCPRHPDLPVPL
460 470 480 490 500 510
1220 1230 1240 1250 1260 1270
pF1KE4 QELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRARYQGQPVAVKRFHIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRARYQGQPVAVKRFHIK
520 530 540 550 560 570
1280 1290 1300 1310 1320 1330
pF1KE4 KFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISIHPLCFALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISIHPLCFALE
580 590 600 610 620 630
1340 1350 1360 1370 1380 1390
pF1KE4 LAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVW
640 650 660 670 680 690
1400 1410 1420 1430 1440 1450
pF1KE4 SLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLY
700 710 720 730 740 750
1460 1470 1480 1490 1500 1510
pF1KE4 ELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALS
760 770 780 790 800 810
1520 1530 1540 1550 1560 1570
pF1KE4 VVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESRNYTVVNTEKGLMEVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESRNYTVVNTEKGLMEVQ
820 830 840 850 860 870
1580 1590 1600 1610 1620 1630
pF1KE4 RMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQALDTPAVVTCFLAVPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQALDTPAVVTCFLAVPV
880 890 900 910 920 930
1640 1650 1660 1670 1680 1690
pF1KE4 IKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFSIADEDARQNPYPVKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFSIADEDARQNPYPVKA
940 950 960 970 980 990
1700 1710 1720 1730 1740 1750
pF1KE4 MEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVVCSSEGRGEEVVWCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVVCSSEGRGEEVVWCLD
1000 1010 1020 1030 1040 1050
1760 1770 1780 1790 1800 1810
pF1KE4 DKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAASHTANPKVPEGDSIAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAASHTANPKVPEGDSIAD
1060 1070 1080 1090 1100 1110
1820 1830 1840 1850 1860 1870
pF1KE4 VSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLPSSPASSSSVPFSTDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLPSSPASSSSVPFSTDC
1120 1130 1140 1150 1160 1170
1880 1890 1900 1910 1920 1930
pF1KE4 EDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIWVPRRGGDVIVIGLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIWVPRRGGDVIVIGLEK
1180 1190 1200 1210 1220 1230
1940 1950 1960 1970 1980 1990
pF1KE4 DSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTEWCLAVWRGWGAREFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTEWCLAVWRGWGAREFD
1240 1250 1260 1270 1280 1290
2000 2010
pF1KE4 IFYQSYEELGRLEACTRKRR
::::::::::::::::::::
XP_011 IFYQSYEELGRLEACTRKRR
1300 1310
>>XP_005255036 (OMIM: 610986) leucine-rich repeat serine (1310 aa)
initn: 8811 init1: 8811 opt: 8811 Z-score: 2771.3 bits: 525.7 E(91774): 1.4e-147
Smith-Waterman score: 8811; 100.0% identity (100.0% similar) in 1310 aa overlap (706-2015:1-1310)
680 690 700 710 720 730
pF1KE4 TKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGEEAVAN
::::::::::::::::::::::::::::::
XP_005 MATVNQCFFTDKALYVVVWNLALGEEAVAN
10 20 30
740 750 760 770 780 790
pF1KE4 LQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATGFPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATGFPD
40 50 60 70 80 90
800 810 820 830 840 850
pF1KE4 ITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAGRLIPRSYLSLQEAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAGRLIPRSYLSLQEAVL
100 110 120 130 140 150
860 870 880 890 900 910
pF1KE4 AEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFLIETGTLLHFPDTSHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFLIETGTLLHFPDTSHG
160 170 180 190 200 210
920 930 940 950 960 970
pF1KE4 LRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGTGFTQQTEEQYFQFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGTGFTQQTEEQYFQFL
220 230 240 250 260 270
980 990 1000 1010 1020 1030
pF1KE4 AKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKMSFVPVGFWQRFIARM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKMSFVPVGFWQRFIARM
280 290 300 310 320 330
1040 1050 1060 1070 1080 1090
pF1KE4 LISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKRNQTIYWQEGLLVTFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKRNQTIYWQEGLLVTFD
340 350 360 370 380 390
1100 1110 1120 1130 1140 1150
pF1KE4 GGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSLIDQWFPALTATESDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSLIDQWFPALTATESDG
400 410 420 430 440 450
1160 1170 1180 1190 1200 1210
pF1KE4 TPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIERDFISCPRHPDLPVPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIERDFISCPRHPDLPVPL
460 470 480 490 500 510
1220 1230 1240 1250 1260 1270
pF1KE4 QELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRARYQGQPVAVKRFHIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRARYQGQPVAVKRFHIK
520 530 540 550 560 570
1280 1290 1300 1310 1320 1330
pF1KE4 KFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISIHPLCFALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISIHPLCFALE
580 590 600 610 620 630
1340 1350 1360 1370 1380 1390
pF1KE4 LAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVW
640 650 660 670 680 690
1400 1410 1420 1430 1440 1450
pF1KE4 SLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLY
700 710 720 730 740 750
1460 1470 1480 1490 1500 1510
pF1KE4 ELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALS
760 770 780 790 800 810
1520 1530 1540 1550 1560 1570
pF1KE4 VVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESRNYTVVNTEKGLMEVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESRNYTVVNTEKGLMEVQ
820 830 840 850 860 870
1580 1590 1600 1610 1620 1630
pF1KE4 RMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQALDTPAVVTCFLAVPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQALDTPAVVTCFLAVPV
880 890 900 910 920 930
1640 1650 1660 1670 1680 1690
pF1KE4 IKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFSIADEDARQNPYPVKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFSIADEDARQNPYPVKA
940 950 960 970 980 990
1700 1710 1720 1730 1740 1750
pF1KE4 MEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVVCSSEGRGEEVVWCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVVCSSEGRGEEVVWCLD
1000 1010 1020 1030 1040 1050
1760 1770 1780 1790 1800 1810
pF1KE4 DKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAASHTANPKVPEGDSIAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAASHTANPKVPEGDSIAD
1060 1070 1080 1090 1100 1110
1820 1830 1840 1850 1860 1870
pF1KE4 VSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLPSSPASSSSVPFSTDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLPSSPASSSSVPFSTDC
1120 1130 1140 1150 1160 1170
1880 1890 1900 1910 1920 1930
pF1KE4 EDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIWVPRRGGDVIVIGLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIWVPRRGGDVIVIGLEK
1180 1190 1200 1210 1220 1230
1940 1950 1960 1970 1980 1990
pF1KE4 DSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTEWCLAVWRGWGAREFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTEWCLAVWRGWGAREFD
1240 1250 1260 1270 1280 1290
2000 2010
pF1KE4 IFYQSYEELGRLEACTRKRR
::::::::::::::::::::
XP_005 IFYQSYEELGRLEACTRKRR
1300 1310
>>XP_011520320 (OMIM: 610986) leucine-rich repeat serine (1310 aa)
initn: 8811 init1: 8811 opt: 8811 Z-score: 2771.3 bits: 525.7 E(91774): 1.4e-147
Smith-Waterman score: 8811; 100.0% identity (100.0% similar) in 1310 aa overlap (706-2015:1-1310)
680 690 700 710 720 730
pF1KE4 TKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGEEAVAN
::::::::::::::::::::::::::::::
XP_011 MATVNQCFFTDKALYVVVWNLALGEEAVAN
10 20 30
740 750 760 770 780 790
pF1KE4 LQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATGFPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATGFPD
40 50 60 70 80 90
800 810 820 830 840 850
pF1KE4 ITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAGRLIPRSYLSLQEAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAGRLIPRSYLSLQEAVL
100 110 120 130 140 150
860 870 880 890 900 910
pF1KE4 AEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFLIETGTLLHFPDTSHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFLIETGTLLHFPDTSHG
160 170 180 190 200 210
920 930 940 950 960 970
pF1KE4 LRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGTGFTQQTEEQYFQFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGTGFTQQTEEQYFQFL
220 230 240 250 260 270
980 990 1000 1010 1020 1030
pF1KE4 AKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKMSFVPVGFWQRFIARM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKMSFVPVGFWQRFIARM
280 290 300 310 320 330
1040 1050 1060 1070 1080 1090
pF1KE4 LISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKRNQTIYWQEGLLVTFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKRNQTIYWQEGLLVTFD
340 350 360 370 380 390
1100 1110 1120 1130 1140 1150
pF1KE4 GGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSLIDQWFPALTATESDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSLIDQWFPALTATESDG
400 410 420 430 440 450
1160 1170 1180 1190 1200 1210
pF1KE4 TPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIERDFISCPRHPDLPVPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIERDFISCPRHPDLPVPL
460 470 480 490 500 510
1220 1230 1240 1250 1260 1270
pF1KE4 QELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRARYQGQPVAVKRFHIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRARYQGQPVAVKRFHIK
520 530 540 550 560 570
1280 1290 1300 1310 1320 1330
pF1KE4 KFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISIHPLCFALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISIHPLCFALE
580 590 600 610 620 630
1340 1350 1360 1370 1380 1390
pF1KE4 LAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVW
640 650 660 670 680 690
1400 1410 1420 1430 1440 1450
pF1KE4 SLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLY
700 710 720 730 740 750
1460 1470 1480 1490 1500 1510
pF1KE4 ELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALS
760 770 780 790 800 810
1520 1530 1540 1550 1560 1570
pF1KE4 VVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESRNYTVVNTEKGLMEVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESRNYTVVNTEKGLMEVQ
820 830 840 850 860 870
1580 1590 1600 1610 1620 1630
pF1KE4 RMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQALDTPAVVTCFLAVPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQALDTPAVVTCFLAVPV
880 890 900 910 920 930
1640 1650 1660 1670 1680 1690
pF1KE4 IKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFSIADEDARQNPYPVKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFSIADEDARQNPYPVKA
940 950 960 970 980 990
1700 1710 1720 1730 1740 1750
pF1KE4 MEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVVCSSEGRGEEVVWCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVVCSSEGRGEEVVWCLD
1000 1010 1020 1030 1040 1050
1760 1770 1780 1790 1800 1810
pF1KE4 DKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAASHTANPKVPEGDSIAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAASHTANPKVPEGDSIAD
1060 1070 1080 1090 1100 1110
1820 1830 1840 1850 1860 1870
pF1KE4 VSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLPSSPASSSSVPFSTDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLPSSPASSSSVPFSTDC
1120 1130 1140 1150 1160 1170
1880 1890 1900 1910 1920 1930
pF1KE4 EDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIWVPRRGGDVIVIGLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIWVPRRGGDVIVIGLEK
1180 1190 1200 1210 1220 1230
1940 1950 1960 1970 1980 1990
pF1KE4 DSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTEWCLAVWRGWGAREFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTEWCLAVWRGWGAREFD
1240 1250 1260 1270 1280 1290
2000 2010
pF1KE4 IFYQSYEELGRLEACTRKRR
::::::::::::::::::::
XP_011 IFYQSYEELGRLEACTRKRR
1300 1310
2015 residues in 1 query sequences
64092750 residues in 91774 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Jul 16 15:53:53 2019 done: Tue Jul 16 15:53:55 2019
Total Scan time: 10.720 Total Display time: 0.770
Function used was FASTA [36.3.4 Apr, 2011]