FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4367, 386 aa 1>>>pF1KE4367 386 - 386 aa - 386 aa Library: /omim/omim.rfq.tfa 64369986 residues in 92320 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8526+/-0.000331; mu= 16.0017+/- 0.021 mean_var=118.7797+/-23.618, 0's: 0 Z-trim(118.3): 61 B-trim: 62 in 1/52 Lambda= 0.117680 statistics sampled from 32318 (32380) to 32318 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.719), E-opt: 0.2 (0.351), width: 16 Scan time: 5.050 The best scores are: opt bits E(92320) NP_003831 (OMIM: 603614) tumor necrosis factor rec ( 386) 2571 447.4 2.9e-125 NP_003833 (OMIM: 275355,603612) tumor necrosis fac ( 440) 1090 196.0 1.6e-49 NP_003832 (OMIM: 603613) tumor necrosis factor rec ( 259) 819 149.8 7.6e-36 NP_671716 (OMIM: 275355,603612) tumor necrosis fac ( 411) 664 123.7 8.8e-28 NP_003835 (OMIM: 603611) tumor necrosis factor rec ( 468) 632 118.3 4.1e-26 NP_001307548 (OMIM: 134637,601859) tumor necrosis ( 197) 226 49.0 1.3e-05 NP_690611 (OMIM: 134637,601859) tumor necrosis fac ( 220) 226 49.0 1.4e-05 NP_000034 (OMIM: 134637,601859) tumor necrosis fac ( 335) 226 49.2 1.8e-05 XP_011538069 (OMIM: 134637,601859) tumor necrosis ( 350) 226 49.2 1.9e-05 XP_011538068 (OMIM: 134637,601859) tumor necrosis ( 362) 226 49.2 1.9e-05 XP_006717882 (OMIM: 134637,601859) tumor necrosis ( 362) 226 49.2 1.9e-05 XP_011538066 (OMIM: 134637,601859) tumor necrosis ( 389) 226 49.3 2e-05 NP_001284534 (OMIM: 602746) tumor necrosis factor ( 184) 218 47.6 3.1e-05 XP_006711082 (OMIM: 602746) tumor necrosis factor ( 197) 218 47.6 3.3e-05 NP_003811 (OMIM: 602746) tumor necrosis factor rec ( 283) 218 47.8 4.2e-05 NP_690610 (OMIM: 134637,601859) tumor necrosis fac ( 314) 217 47.6 5.1e-05 NP_002537 (OMIM: 239000,602643) tumor necrosis fac ( 401) 218 47.9 5.4e-05 XP_011538067 (OMIM: 134637,601859) tumor necrosis ( 368) 217 47.7 5.7e-05 NP_001056 (OMIM: 142680,191190,614810) tumor necro ( 455) 207 46.1 0.00021 NP_002498 (OMIM: 162010) tumor necrosis factor rec ( 427) 197 44.4 0.00066 XP_016857721 (OMIM: 600315,615593) tumor necrosis ( 277) 176 40.6 0.0058 NP_003318 (OMIM: 600315,615593) tumor necrosis fac ( 277) 176 40.6 0.0058 XP_016857720 (OMIM: 600315,615593) tumor necrosis ( 303) 176 40.7 0.0062 XP_011540377 (OMIM: 600315,615593) tumor necrosis ( 303) 176 40.7 0.0062 >>NP_003831 (OMIM: 603614) tumor necrosis factor recepto (386 aa) initn: 2571 init1: 2571 opt: 2571 Z-score: 2370.5 bits: 447.4 E(92320): 2.9e-125 Smith-Waterman score: 2571; 99.7% identity (99.7% similar) in 386 aa overlap (1-386:1-386) 10 20 30 40 50 60 pF1KE4 MGLWGQSVPTASSARAGRYPGARTASGTRPWLLDPKILKFVVFIVAVLLPVRVDSATIPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MGLWGQSVPTASSARAGRYPGARTASGTRPWLLDPKILKFVVFIVAVLLPVRVDSATIPR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 QDEVPQQTVAPQQQRRSLKEEECPAGSHRSEYTGACNPCTEGVDYTIASNNLPSCLLCTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QDEVPQQTVAPQQQRRSLKEEECPAGSHRSEYTGACNPCTEGVDYTIASNNLPSCLLCTV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 CKSGQTNKSSCTTTRDTVCQCEKGSFQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 CKSGQTNKSSCTTTRDTVCQCEKGSFQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIKC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 KNESAASSTGKTPAAEETVTTILGMLASPYHYLIIIVVLVIILAVVVVGFSCRKKFISYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KNESAASSTGKTPAAEETVTTILGMLASPYHYLIIIVVLVIILAVVVVGFSCRKKFISYL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 KGICSGGGGGPERVHRVLFRRRSCPSRVPGAEDNARNETLSNRYLQPTQVSEQEIQGQEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KGICSGGGGGPERVHRVLFRRRSCPSRVPGAEDNARNETLSNRYLQPTQVSEQEIQGQEL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 AELTGVTVESPEEPQRLLEQAEAEGCQRRRLLVPVNDADSADISTLLDASATLEEGHAKE ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AELTGVTVELPEEPQRLLEQAEAEGCQRRRLLVPVNDADSADISTLLDASATLEEGHAKE 310 320 330 340 350 360 370 380 pF1KE4 TIQDQLVGSEKLFYEEDEAGSATSCL :::::::::::::::::::::::::: NP_003 TIQDQLVGSEKLFYEEDEAGSATSCL 370 380 >>NP_003833 (OMIM: 275355,603612) tumor necrosis factor (440 aa) initn: 1035 init1: 582 opt: 1090 Z-score: 1010.9 bits: 196.0 E(92320): 1.6e-49 Smith-Waterman score: 1090; 53.0% identity (71.6% similar) in 345 aa overlap (5-342:5-336) 10 20 30 40 50 pF1KE4 MGLWGQSVPTASSARAGRYPGARTASGTRPWLLDPKILKFVVFIVA-VLLPVRVDSATIP ::..:.::.:: . :: : : :.:: :.. : .:..:: ::: : ..:: : NP_003 MEQRGQNAPAASGARKRHGPGPREARGARP---GPRVPKTLVLVVAAVLLLVSAESALIT 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 RQDEVPQQTVAPQQQRRSLKEEECPAGSHRSEYTGACNPCTEGVDYTIASNNLPSCLLCT .:: .::: .::::.: : .: :: : : :: : : : ::. :.: :: :: NP_003 QQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 VCKSGQTNKSSCTTTRDTVCQCEKGSFQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIK : ::... : :::::.::::::.:.:....:::::: ::::::::::::..::: :::. NP_003 RCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIE 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 C-KNESAASSTGKTPAAEETVTTILGMLASPYHYL-IIIVVLVIILAVVVVGFSCR---- : ..::... .:..::.:::::. : ::: ::: : : ....:. : :. NP_003 CVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLW 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 KKFISYLKGICSGGGGGPERVHRVLFRRRSCPSRVPGAEDNARNETLSNRYLQPTQVSEQ :: . ::::::::::: :::: : :. ::::::. :: .: :::::: :: NP_003 KKVLPYLKGICSGGGGDPERVDR--------SSQRPGAEDNVLNEIVS--ILQPTQVPEQ 240 250 260 270 280 300 310 320 330 340 350 pF1KE4 EIQGQELAELTGVTVESPEEPQRLLEQAEAEGCQRRRLLVPVNDADSADISTLLDASATL :.. :: :: :::.. :: : ..::: :::: ::::::::.:..: .. NP_003 EMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFAD 290 300 310 320 330 340 360 370 380 pF1KE4 EEGHAKETIQDQLVGSEKLFYEEDEAGSATSCL NP_003 LVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALE 350 360 370 380 390 400 >>NP_003832 (OMIM: 603613) tumor necrosis factor recepto (259 aa) initn: 913 init1: 680 opt: 819 Z-score: 765.1 bits: 149.8 E(92320): 7.6e-36 Smith-Waterman score: 819; 71.2% identity (85.3% similar) in 170 aa overlap (35-204:5-173) 10 20 30 40 50 60 pF1KE4 GQSVPTASSARAGRYPGARTASGTRPWLLDPKILKFVVFIVAVLLPVRVDSATIPRQDEV :: ::::: :::::::: . ::: ::.:: NP_003 MARIPKTLKFVVVIVAVLLPVLAYSATTARQEEV 10 20 30 70 80 90 100 110 120 pF1KE4 PQQTVAPQQQRRSLKEEECPAGSHRSEYTGACNPCTEGVDYTIASNNLPSCLLCTVCKSG :::::::::::.:.: :::::::::::.:::::::::::::: :::: :::. :::::: NP_003 PQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCTEGVDYTNASNNEPSCFPCTVCKSD 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE4 QTNKSSCTTTRDTVCQCEKGSFQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIKCKNES : .::::: ::::::::..:.:...::::::: : . :: : :.::::: .::.: .: NP_003 QKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKC-SRCPSGEVQVSNCTSWDDIQCVEEF 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE4 AASSTGKTPAAEETVTTILGMLASPYHYLIIIVVLVIILAVVVVGFSCRKKFISYLKGIC .:..: .:::::::..: : NP_003 GANATVETPAAEETMNTSPGTPAPAAEETMNTSPGTPAPAAEETMTTSPGTPAPAAEETM 160 170 180 190 200 210 >>NP_671716 (OMIM: 275355,603612) tumor necrosis factor (411 aa) initn: 1028 init1: 575 opt: 664 Z-score: 620.4 bits: 123.7 E(92320): 8.8e-28 Smith-Waterman score: 980; 49.6% identity (67.3% similar) in 339 aa overlap (5-342:5-307) 10 20 30 40 50 pF1KE4 MGLWGQSVPTASSARAGRYPGARTASGTRPWLLDPKILKFVVFIVA-VLLPVRVDSATIP ::..:.::.:: . :: : : :.:: :.. : .:..:: ::: : ..:: : NP_671 MEQRGQNAPAASGARKRHGPGPREARGARP---GPRVPKTLVLVVAAVLLLVSAESALIT 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 RQDEVPQQTVAPQQQRRSLKEEECPAGSHRSEYTGACNPCTEGVDYTIASNNLPSCLLCT .:: .::: .::::.: : .: :: : : :: : : : ::. :.: :: :: NP_671 QQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 VCKSGQTNKSSCTTTRDTVCQCEKGSFQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIK : ::... : :::::.::::::.:.:....:::::: ::::::::::::..::: :::. NP_671 RCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIE 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 CKNESAASSTGKTPAAEETVTTILGMLASPYHYLIIIVVLVIILAVVVVGFSCRKKFISY : .. .. :.: . ....:.:.:: : :: . : NP_671 CVHKESG--------------IIIG---------VTVAAVVLIVAVFVCKSLLWKKVLPY 180 190 200 210 240 250 260 270 280 290 pF1KE4 LKGICSGGGGGPERVHRVLFRRRSCPSRVPGAEDNARNETLSNRYLQPTQVSEQEIQGQE :::::::::: :::: : :. ::::::. :: .: :::::: :::.. :: NP_671 LKGICSGGGGDPERVDR--------SSQRPGAEDNVLNEIVS--ILQPTQVPEQEMEVQE 220 230 240 250 260 300 310 320 330 340 350 pF1KE4 LAELTGVTVESPEEPQRLLEQAEAEGCQRRRLLVPVNDADSADISTLLDASATLEEGHAK :: :::.. :: : ..::: :::: ::::::::.:..: .. NP_671 PAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDS 270 280 290 300 310 320 360 370 380 pF1KE4 ETIQDQLVGSEKLFYEEDEAGSATSCL NP_671 WEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERL 330 340 350 360 370 380 >>NP_003835 (OMIM: 603611) tumor necrosis factor recepto (468 aa) initn: 1043 init1: 517 opt: 632 Z-score: 590.4 bits: 118.3 E(92320): 4.1e-26 Smith-Waterman score: 918; 44.2% identity (57.8% similar) in 443 aa overlap (5-384:60-466) 10 20 30 pF1KE4 MGLWGQSVPTASSARAGRYPGARTASGTRPWLLD :: :.: ::::: :: : : . : : NP_003 AAATPSKVWGSSAGRIEPRGGGRGALPTSMGQHGPSAR-ARAGRAPGPRPAREASPRLRV 30 40 50 60 70 80 40 50 60 70 80 90 pF1KE4 PKILKFVVFIVAVLLPVRVDSA-TIPRQDEVPQQTVAPQQQRRSLKEEECPAGSHRSEYT : .:::: :.::: : .:: :: .: :... :: ..: : :: ::::::. NP_003 HKTFKFVV--VGVLLQVVPSSAATIKLHD----QSIGTQQWEHSPLGELCPPGSHRSEHP 90 100 110 120 130 140 100 110 120 130 140 150 pF1KE4 GACNPCTEGVDYTIASNNLPSCLLCTVCKSGQTNKSSCTTTRDTVCQCEKGSFQDKNSPE :::: ::::: :: ::::: .:: ::.::: . ..: :::::.:.:::. :.:.. :: : NP_003 GACNRCTEGVGYTNASNNLFACLPCTACKSDEEERSPCTTTRNTACQCKPGTFRNDNSAE 150 160 170 180 190 200 160 170 180 190 200 210 pF1KE4 MCRTCRTGCPRGMVKVSNCTPRSDIKCKNESAASSTGKTPAAEETVTTILGMLASPYHYL ::: : :::::::::..::: :::.: .. :..:.. .. NP_003 MCRKCSRGCPRGMVKVKDCTPWSDIECVHKE--SGNGHNI------------------WV 210 220 230 240 220 230 240 250 260 270 pF1KE4 IIIVVLVIILAVVVVGFSCRKKFISYLKGICSGGGGGPERVHRVLFRRRSCPSRVPGAED :..:.::. : .:.: . : : :: :: :. . :: : : . : ::::: NP_003 ILVVTLVVPLLLVAVLIVC--------CCIGSGCGGDPKCMDRVCFWRLGL-LRGPGAED 250 260 270 280 290 280 290 300 310 320 330 pF1KE4 NARNETLSNRYLQPTQVSEQEIQGQELAELTGVTVESPEEPQRLLEQAEAEGCQRRRLLV ::.:: ::: : ::::....:: :.::::::.:: : : :: ::::: ::::::: NP_003 NAHNEILSNADSLSTFVSEQQMESQEPADLTGVTVQSPGEAQCLLGPAEAEGSQRRRLLV 300 310 320 330 340 350 pF1KE4 PVNDAD------------------------------------------------------ :.: :: NP_003 PANGADPTETLMLFFDKFANIVPFDSWDQLMRQLDLTKNEIDVVRAGTAGPGDALYAMLM 360 370 380 390 400 410 340 350 360 370 380 pF1KE4 --------SADISTLLDASATLEEGHAKETIQDQLVGSEKLFYEEDEAGSATSCL .:.: ::::: .:: ::.: ::: :: : :..: :: .:::.: NP_003 KWVNKTGRNASIHTLLDALERMEERHAREKIQDLLVDSGKFIYLEDGTGSAVSLE 420 430 440 450 460 >>NP_001307548 (OMIM: 134637,601859) tumor necrosis fact (197 aa) initn: 174 init1: 97 opt: 226 Z-score: 222.5 bits: 49.0 E(92320): 1.3e-05 Smith-Waterman score: 226; 29.6% identity (57.8% similar) in 135 aa overlap (64-190:44-175) 40 50 60 70 80 90 pF1KE4 DPKILKFVVFIVAVLLPVRVDSATIPRQDEVPQQTVAPQQQRRSLKEEECPAGSHRSE-- : :.. .. .. .. :: : .... NP_001 SVARLSSKSVNAQVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCHKPCPPGERKARDC 20 30 40 50 60 70 100 110 120 130 140 pF1KE4 -YTGA---CNPCTEGVDYTIASNNLPSCLLCTVCKSGQ--TNKSSCTTTRDTVCQCEKGS .: : :: :: .:: .. .: : .: :. . .:: :..: :.:. . NP_001 TVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINCTRTQNTKCRCKPNF 80 90 100 110 120 130 150 160 170 180 190 200 pF1KE4 FQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIKCKNESAASSTGKTPAAEETVTTILGM : ... : : : : : .:..: .:: :. :::.:.. :. : NP_001 FCNSTVCEHCDPC-TKCEHGIIK--ECTLTSNTKCKEEGSRSNLGWLCLLLLPIPLIVWG 140 150 160 170 180 190 210 220 230 240 250 260 pF1KE4 LASPYHYLIIIVVLVIILAVVVVGFSCRKKFISYLKGICSGGGGGPERVHRVLFRRRSCP NP_001 NSGNKFI >>NP_690611 (OMIM: 134637,601859) tumor necrosis factor (220 aa) initn: 174 init1: 97 opt: 226 Z-score: 221.9 bits: 49.0 E(92320): 1.4e-05 Smith-Waterman score: 226; 29.6% identity (57.8% similar) in 135 aa overlap (64-190:44-175) 40 50 60 70 80 90 pF1KE4 DPKILKFVVFIVAVLLPVRVDSATIPRQDEVPQQTVAPQQQRRSLKEEECPAGSHRSE-- : :.. .. .. .. :: : .... NP_690 SVARLSSKSVNAQVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCHKPCPPGERKARDC 20 30 40 50 60 70 100 110 120 130 140 pF1KE4 -YTGA---CNPCTEGVDYTIASNNLPSCLLCTVCKSGQ--TNKSSCTTTRDTVCQCEKGS .: : :: :: .:: .. .: : .: :. . .:: :..: :.:. . NP_690 TVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINCTRTQNTKCRCKPNF 80 90 100 110 120 130 150 160 170 180 190 200 pF1KE4 FQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIKCKNESAASSTGKTPAAEETVTTILGM : ... : : : : : .:..: .:: :. :::.:.. :. : NP_690 FCNSTVCEHCDPC-TKCEHGIIK--ECTLTSNTKCKEEGSRSNLGWLCLLLLPIPLIVWV 140 150 160 170 180 190 210 220 230 240 250 260 pF1KE4 LASPYHYLIIIVVLVIILAVVVVGFSCRKKFISYLKGICSGGGGGPERVHRVLFRRRSCP NP_690 KRKEVQKTCRKHRKENQGSHESPTLNPMLT 200 210 220 >>NP_000034 (OMIM: 134637,601859) tumor necrosis factor (335 aa) initn: 175 init1: 97 opt: 226 Z-score: 219.6 bits: 49.2 E(92320): 1.8e-05 Smith-Waterman score: 226; 29.6% identity (57.8% similar) in 135 aa overlap (64-190:44-175) 40 50 60 70 80 90 pF1KE4 DPKILKFVVFIVAVLLPVRVDSATIPRQDEVPQQTVAPQQQRRSLKEEECPAGSHRSE-- : :.. .. .. .. :: : .... NP_000 SVARLSSKSVNAQVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCHKPCPPGERKARDC 20 30 40 50 60 70 100 110 120 130 140 pF1KE4 -YTGA---CNPCTEGVDYTIASNNLPSCLLCTVCKSGQ--TNKSSCTTTRDTVCQCEKGS .: : :: :: .:: .. .: : .: :. . .:: :..: :.:. . NP_000 TVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINCTRTQNTKCRCKPNF 80 90 100 110 120 130 150 160 170 180 190 200 pF1KE4 FQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIKCKNESAASSTGKTPAAEETVTTILGM : ... : : : : : .:..: .:: :. :::.:.. :. : NP_000 FCNSTVCEHCDPC-TKCEHGIIK--ECTLTSNTKCKEEGSRSNLGWLCLLLLPIPLIVWV 140 150 160 170 180 190 210 220 230 240 250 260 pF1KE4 LASPYHYLIIIVVLVIILAVVVVGFSCRKKFISYLKGICSGGGGGPERVHRVLFRRRSCP NP_000 KRKEVQKTCRKHRKENQGSHESPTLNPETVAINLSDVDLSKYITTIAGVMTLSQVKGFVR 200 210 220 230 240 250 >>XP_011538069 (OMIM: 134637,601859) tumor necrosis fact (350 aa) initn: 175 init1: 97 opt: 226 Z-score: 219.4 bits: 49.2 E(92320): 1.9e-05 Smith-Waterman score: 226; 29.6% identity (57.8% similar) in 135 aa overlap (64-190:59-190) 40 50 60 70 80 90 pF1KE4 DPKILKFVVFIVAVLLPVRVDSATIPRQDEVPQQTVAPQQQRRSLKEEECPAGSHRSE-- : :.. .. .. .. :: : .... XP_011 SVARLSSKSVNAQVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCHKPCPPGERKARDC 30 40 50 60 70 80 100 110 120 130 140 pF1KE4 -YTGA---CNPCTEGVDYTIASNNLPSCLLCTVCKSGQ--TNKSSCTTTRDTVCQCEKGS .: : :: :: .:: .. .: : .: :. . .:: :..: :.:. . XP_011 TVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINCTRTQNTKCRCKPNF 90 100 110 120 130 140 150 160 170 180 190 200 pF1KE4 FQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIKCKNESAASSTGKTPAAEETVTTILGM : ... : : : : : .:..: .:: :. :::.:.. :. : XP_011 FCNSTVCEHCDPC-TKCEHGIIK--ECTLTSNTKCKEEGSRSNLGWLCLLLLPIPLIVWV 150 160 170 180 190 200 210 220 230 240 250 260 pF1KE4 LASPYHYLIIIVVLVIILAVVVVGFSCRKKFISYLKGICSGGGGGPERVHRVLFRRRSCP XP_011 KRKEVQKTCRKHRKENQGSHESPTLNPETVAINLSDVDLSKYITTIAGVMTLSQVKGFVR 210 220 230 240 250 260 >>XP_011538068 (OMIM: 134637,601859) tumor necrosis fact (362 aa) initn: 175 init1: 97 opt: 226 Z-score: 219.2 bits: 49.2 E(92320): 1.9e-05 Smith-Waterman score: 226; 29.6% identity (57.8% similar) in 135 aa overlap (64-190:71-202) 40 50 60 70 80 90 pF1KE4 DPKILKFVVFIVAVLLPVRVDSATIPRQDEVPQQTVAPQQQRRSLKEEECPAGSHRSE-- : :.. .. .. .. :: : .... XP_011 SVARLSSKSVNAQVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCHKPCPPGERKARDC 50 60 70 80 90 100 100 110 120 130 140 pF1KE4 -YTGA---CNPCTEGVDYTIASNNLPSCLLCTVCKSGQ--TNKSSCTTTRDTVCQCEKGS .: : :: :: .:: .. .: : .: :. . .:: :..: :.:. . XP_011 TVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINCTRTQNTKCRCKPNF 110 120 130 140 150 160 150 160 170 180 190 200 pF1KE4 FQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIKCKNESAASSTGKTPAAEETVTTILGM : ... : : : : : .:..: .:: :. :::.:.. :. : XP_011 FCNSTVCEHCDPC-TKCEHGIIK--ECTLTSNTKCKEEGSRSNLGWLCLLLLPIPLIVWV 170 180 190 200 210 210 220 230 240 250 260 pF1KE4 LASPYHYLIIIVVLVIILAVVVVGFSCRKKFISYLKGICSGGGGGPERVHRVLFRRRSCP XP_011 KRKEVQKTCRKHRKENQGSHESPTLNPETVAINLSDVDLSKYITTIAGVMTLSQVKGFVR 220 230 240 250 260 270 386 residues in 1 query sequences 64369986 residues in 92320 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Oct 24 21:41:36 2019 done: Thu Oct 24 21:41:37 2019 Total Scan time: 5.050 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]