FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4446, 461 aa 1>>>pF1KE4446 461 - 461 aa - 461 aa Library: /omim/omim.rfq.tfa 65089639 residues in 91964 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3784+/-0.000396; mu= 17.0468+/- 0.025 mean_var=66.0190+/-13.200, 0's: 0 Z-trim(112.0): 51 B-trim: 527 in 1/48 Lambda= 0.157848 statistics sampled from 21483 (21536) to 21483 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.607), E-opt: 0.2 (0.234), width: 16 Scan time: 4.090 The best scores are: opt bits E(91964) NP_002530 (OMIM: 165640) ornithine decarboxylase i ( 461) 3101 715.4 8.5e-206 NP_001274119 (OMIM: 165640) ornithine decarboxylas ( 461) 3101 715.4 8.5e-206 NP_001274118 (OMIM: 165640) ornithine decarboxylas ( 461) 3101 715.4 8.5e-206 NP_001274117 (OMIM: 165640) ornithine decarboxylas ( 332) 2238 518.8 9.3e-147 XP_005270461 (OMIM: 608353) antizyme inhibitor 2 i ( 460) 1569 366.5 9e-101 NP_443724 (OMIM: 608353) antizyme inhibitor 2 isof ( 460) 1569 366.5 9e-101 NP_001280491 (OMIM: 608353) antizyme inhibitor 2 i ( 460) 1569 366.5 9e-101 NP_001349939 (OMIM: 607909) antizyme inhibitor 1 i ( 447) 1517 354.7 3.2e-97 NP_001349941 (OMIM: 607909) antizyme inhibitor 1 i ( 447) 1517 354.7 3.2e-97 NP_001349940 (OMIM: 607909) antizyme inhibitor 1 i ( 447) 1517 354.7 3.2e-97 NP_680479 (OMIM: 607909) antizyme inhibitor 1 isof ( 448) 1506 352.2 1.8e-96 NP_001350012 (OMIM: 607909) antizyme inhibitor 1 i ( 448) 1506 352.2 1.8e-96 NP_056962 (OMIM: 607909) antizyme inhibitor 1 isof ( 448) 1506 352.2 1.8e-96 NP_001349953 (OMIM: 607909) antizyme inhibitor 1 i ( 448) 1506 352.2 1.8e-96 XP_011538859 (OMIM: 608353) antizyme inhibitor 2 i ( 402) 1299 305.0 2.6e-82 XP_005270463 (OMIM: 608353) antizyme inhibitor 2 i ( 402) 1299 305.0 2.6e-82 XP_016855660 (OMIM: 608353) antizyme inhibitor 2 i ( 365) 1285 301.8 2.2e-81 NP_001337328 (OMIM: 608353) antizyme inhibitor 2 i ( 365) 1285 301.8 2.2e-81 XP_024308586 (OMIM: 608353) antizyme inhibitor 2 i ( 365) 1285 301.8 2.2e-81 XP_016855664 (OMIM: 608353) antizyme inhibitor 2 i ( 365) 1285 301.8 2.2e-81 XP_016855662 (OMIM: 608353) antizyme inhibitor 2 i ( 365) 1285 301.8 2.2e-81 XP_024308585 (OMIM: 608353) antizyme inhibitor 2 i ( 365) 1285 301.8 2.2e-81 NP_001337330 (OMIM: 608353) antizyme inhibitor 2 i ( 365) 1285 301.8 2.2e-81 NP_001288752 (OMIM: 608353) antizyme inhibitor 2 i ( 365) 1285 301.8 2.2e-81 NP_001337329 (OMIM: 608353) antizyme inhibitor 2 i ( 365) 1285 301.8 2.2e-81 NP_001288753 (OMIM: 608353) antizyme inhibitor 2 i ( 365) 1285 301.8 2.2e-81 NP_001337327 (OMIM: 608353) antizyme inhibitor 2 i ( 365) 1285 301.8 2.2e-81 XP_005270464 (OMIM: 608353) antizyme inhibitor 2 i ( 365) 1285 301.8 2.2e-81 XP_016855656 (OMIM: 608353) antizyme inhibitor 2 i ( 380) 1280 300.7 4.9e-81 NP_001288597 (OMIM: 607909) antizyme inhibitor 1 i ( 363) 1275 299.5 1e-80 XP_011538865 (OMIM: 608353) antizyme inhibitor 2 i ( 362) 1274 299.3 1.2e-80 NP_001288755 (OMIM: 608353) antizyme inhibitor 2 i ( 362) 1274 299.3 1.2e-80 XP_011538868 (OMIM: 608353) antizyme inhibitor 2 i ( 357) 1149 270.8 4.5e-72 XP_016855663 (OMIM: 608353) antizyme inhibitor 2 i ( 358) 1149 270.8 4.5e-72 NP_001288754 (OMIM: 608353) antizyme inhibitor 2 i ( 480) 1149 270.9 5.8e-72 NP_001337331 (OMIM: 608353) antizyme inhibitor 2 i ( 309) 1036 245.1 2.2e-64 XP_016855665 (OMIM: 608353) antizyme inhibitor 2 i ( 309) 1036 245.1 2.2e-64 XP_006710375 (OMIM: 608353) antizyme inhibitor 2 i ( 309) 1036 245.1 2.2e-64 XP_016855667 (OMIM: 608353) antizyme inhibitor 2 i ( 309) 1036 245.1 2.2e-64 XP_024308592 (OMIM: 608353) antizyme inhibitor 2 i ( 309) 1036 245.1 2.2e-64 XP_016869055 (OMIM: 607909) antizyme inhibitor 1 i ( 280) 975 231.2 3.1e-60 NP_001349942 (OMIM: 607909) antizyme inhibitor 1 i ( 281) 964 228.7 1.8e-59 NP_001349943 (OMIM: 607909) antizyme inhibitor 1 i ( 281) 964 228.7 1.8e-59 >>NP_002530 (OMIM: 165640) ornithine decarboxylase isofo (461 aa) initn: 3101 init1: 3101 opt: 3101 Z-score: 3816.3 bits: 715.4 E(91964): 8.5e-206 Smith-Waterman score: 3101; 100.0% identity (100.0% similar) in 461 aa overlap (1-461:1-461) 10 20 30 40 50 60 pF1KE4 MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 KYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 SEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 TGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 DGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQF 370 380 390 400 410 420 430 440 450 460 pF1KE4 QNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV ::::::::::::::::::::::::::::::::::::::::: NP_002 QNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV 430 440 450 460 >>NP_001274119 (OMIM: 165640) ornithine decarboxylase is (461 aa) initn: 3101 init1: 3101 opt: 3101 Z-score: 3816.3 bits: 715.4 E(91964): 8.5e-206 Smith-Waterman score: 3101; 100.0% identity (100.0% similar) in 461 aa overlap (1-461:1-461) 10 20 30 40 50 60 pF1KE4 MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 KYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 SEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 TGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 DGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQF 370 380 390 400 410 420 430 440 450 460 pF1KE4 QNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV ::::::::::::::::::::::::::::::::::::::::: NP_001 QNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV 430 440 450 460 >>NP_001274118 (OMIM: 165640) ornithine decarboxylase is (461 aa) initn: 3101 init1: 3101 opt: 3101 Z-score: 3816.3 bits: 715.4 E(91964): 8.5e-206 Smith-Waterman score: 3101; 100.0% identity (100.0% similar) in 461 aa overlap (1-461:1-461) 10 20 30 40 50 60 pF1KE4 MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 KYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 SEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 TGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 DGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQF 370 380 390 400 410 420 430 440 450 460 pF1KE4 QNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV ::::::::::::::::::::::::::::::::::::::::: NP_001 QNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV 430 440 450 460 >>NP_001274117 (OMIM: 165640) ornithine decarboxylase is (332 aa) initn: 2238 init1: 2238 opt: 2238 Z-score: 2756.3 bits: 518.8 E(91964): 9.3e-147 Smith-Waterman score: 2238; 100.0% identity (100.0% similar) in 332 aa overlap (130-461:1-332) 100 110 120 130 140 150 pF1KE4 SLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDD :::::::::::::::::::::::::::::: NP_001 MMTFDSEVELMKVARAHPKAKLVLRIATDD 10 20 30 160 170 180 190 200 210 pF1KE4 SKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVF 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE4 DMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYY 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE4 VASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPL 160 170 180 190 200 210 340 350 360 370 380 390 pF1KE4 LQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNG 220 230 240 250 260 270 400 410 420 430 440 450 pF1KE4 FQRPTIYYVMSGPAWQLMQQFQNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FQRPTIYYVMSGPAWQLMQQFQNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASI 280 290 300 310 320 330 460 pF1KE4 NV :: NP_001 NV >>XP_005270461 (OMIM: 608353) antizyme inhibitor 2 isofo (460 aa) initn: 1533 init1: 1497 opt: 1569 Z-score: 1930.8 bits: 366.5 E(91964): 9e-101 Smith-Waterman score: 1569; 52.5% identity (80.2% similar) in 440 aa overlap (8-444:7-443) 10 20 30 40 50 pF1KE4 MNNFGNEEFDCHFLDEGFTAKDILDQKINEVS--SSDDKDAFYVADLGDILKKHLRWLKA : : ...:::...:.: . .: ..:. ::.::::: :..::. .:: XP_005 MAGYLSESDFVMVEEGFSTRDLLKELTLGASQATTDEVAAFFVADLGAIVRKHFCFLKC 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 LPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVS :::: ::::::::.: ...:.:: : ::.::.:.:..::: .:.: .:: ::::::.. XP_005 LPRVRPFYAVKCNSSPGVLKVLAQLGLGFSCANKAEMELVQHIGIPASKIICANPCKQIA 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 QIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSR ::::::..:.:...::.:.:: ::...::.::.:: ::::::... ::.:::..:.. : XP_005 QIKYAAKHGIQLLSFDNEMELAKVVKSHPSAKMVLCIATDDSHSLSCLSLKFGVSLKSCR 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 LLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGF ::: ::. ...:::::::.:::: ::....:.:.::: ::.::.:.: .:..::.:::: XP_005 HLLENAKKHHVEVVGVSFHIGSGCPDPQAYAQSIADARLVFEMGTELGHKMHVLDLGGGF 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 PGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLK ::.: .:..::::..::: ::: ::: :: :.:: :::::.::::.::.::::: :: XP_005 PGTEGAKVRFEEIASVINSALDLYFPEGCGVDIFAELGRYYVTSAFTVAVSIIAKKEVLL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 EQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGP .: : ..:. :. .:..:....:::: :: .:.:. :.:::.:. .. ::::.::: XP_005 DQPGREEENGSTSKTIVYHLDEGVYGIFNSVLFDNICPTPILQKKPSTEQPLYSSSLWGP 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 TCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQ-LM . :: : ..: ::..:::::..:.:::::::. .: : : : : :.:: ::. : XP_005 AVDGCDCVAEGLWLPQLHVGDWLVFDNMGAYTVGMGSPFWGTQACHITYAMSRVAWEALR 360 370 380 390 400 410 420 430 440 450 460 pF1KE4 QQFQNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV .:.. . .:: . :.::.:: XP_005 RQLMAAEQEDDVE---GVCKPLSCGWEITDTLCVGPVFTPASIM 420 430 440 450 460 >>NP_443724 (OMIM: 608353) antizyme inhibitor 2 isoform (460 aa) initn: 1533 init1: 1497 opt: 1569 Z-score: 1930.8 bits: 366.5 E(91964): 9e-101 Smith-Waterman score: 1569; 52.5% identity (80.2% similar) in 440 aa overlap (8-444:7-443) 10 20 30 40 50 pF1KE4 MNNFGNEEFDCHFLDEGFTAKDILDQKINEVS--SSDDKDAFYVADLGDILKKHLRWLKA : : ...:::...:.: . .: ..:. ::.::::: :..::. .:: NP_443 MAGYLSESDFVMVEEGFSTRDLLKELTLGASQATTDEVAAFFVADLGAIVRKHFCFLKC 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 LPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVS :::: ::::::::.: ...:.:: : ::.::.:.:..::: .:.: .:: ::::::.. NP_443 LPRVRPFYAVKCNSSPGVLKVLAQLGLGFSCANKAEMELVQHIGIPASKIICANPCKQIA 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 QIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSR ::::::..:.:...::.:.:: ::...::.::.:: ::::::... ::.:::..:.. : NP_443 QIKYAAKHGIQLLSFDNEMELAKVVKSHPSAKMVLCIATDDSHSLSCLSLKFGVSLKSCR 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 LLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGF ::: ::. ...:::::::.:::: ::....:.:.::: ::.::.:.: .:..::.:::: NP_443 HLLENAKKHHVEVVGVSFHIGSGCPDPQAYAQSIADARLVFEMGTELGHKMHVLDLGGGF 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 PGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLK ::.: .:..::::..::: ::: ::: :: :.:: :::::.::::.::.::::: :: NP_443 PGTEGAKVRFEEIASVINSALDLYFPEGCGVDIFAELGRYYVTSAFTVAVSIIAKKEVLL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 EQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGP .: : ..:. :. .:..:....:::: :: .:.:. :.:::.:. .. ::::.::: NP_443 DQPGREEENGSTSKTIVYHLDEGVYGIFNSVLFDNICPTPILQKKPSTEQPLYSSSLWGP 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 TCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQ-LM . :: : ..: ::..:::::..:.:::::::. .: : : : : :.:: ::. : NP_443 AVDGCDCVAEGLWLPQLHVGDWLVFDNMGAYTVGMGSPFWGTQACHITYAMSRVAWEALR 360 370 380 390 400 410 420 430 440 450 460 pF1KE4 QQFQNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV .:.. . .:: . :.::.:: NP_443 RQLMAAEQEDDVE---GVCKPLSCGWEITDTLCVGPVFTPASIM 420 430 440 450 460 >>NP_001280491 (OMIM: 608353) antizyme inhibitor 2 isofo (460 aa) initn: 1533 init1: 1497 opt: 1569 Z-score: 1930.8 bits: 366.5 E(91964): 9e-101 Smith-Waterman score: 1569; 52.5% identity (80.2% similar) in 440 aa overlap (8-444:7-443) 10 20 30 40 50 pF1KE4 MNNFGNEEFDCHFLDEGFTAKDILDQKINEVS--SSDDKDAFYVADLGDILKKHLRWLKA : : ...:::...:.: . .: ..:. ::.::::: :..::. .:: NP_001 MAGYLSESDFVMVEEGFSTRDLLKELTLGASQATTDEVAAFFVADLGAIVRKHFCFLKC 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 LPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVS :::: ::::::::.: ...:.:: : ::.::.:.:..::: .:.: .:: ::::::.. NP_001 LPRVRPFYAVKCNSSPGVLKVLAQLGLGFSCANKAEMELVQHIGIPASKIICANPCKQIA 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 QIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSR ::::::..:.:...::.:.:: ::...::.::.:: ::::::... ::.:::..:.. : NP_001 QIKYAAKHGIQLLSFDNEMELAKVVKSHPSAKMVLCIATDDSHSLSCLSLKFGVSLKSCR 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 LLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGF ::: ::. ...:::::::.:::: ::....:.:.::: ::.::.:.: .:..::.:::: NP_001 HLLENAKKHHVEVVGVSFHIGSGCPDPQAYAQSIADARLVFEMGTELGHKMHVLDLGGGF 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 PGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLK ::.: .:..::::..::: ::: ::: :: :.:: :::::.::::.::.::::: :: NP_001 PGTEGAKVRFEEIASVINSALDLYFPEGCGVDIFAELGRYYVTSAFTVAVSIIAKKEVLL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 EQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGP .: : ..:. :. .:..:....:::: :: .:.:. :.:::.:. .. ::::.::: NP_001 DQPGREEENGSTSKTIVYHLDEGVYGIFNSVLFDNICPTPILQKKPSTEQPLYSSSLWGP 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 TCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQ-LM . :: : ..: ::..:::::..:.:::::::. .: : : : : :.:: ::. : NP_001 AVDGCDCVAEGLWLPQLHVGDWLVFDNMGAYTVGMGSPFWGTQACHITYAMSRVAWEALR 360 370 380 390 400 410 420 430 440 450 460 pF1KE4 QQFQNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV .:.. . .:: . :.::.:: NP_001 RQLMAAEQEDDVE---GVCKPLSCGWEITDTLCVGPVFTPASIM 420 430 440 450 460 >>NP_001349939 (OMIM: 607909) antizyme inhibitor 1 isofo (447 aa) initn: 837 init1: 837 opt: 1517 Z-score: 1867.0 bits: 354.7 E(91964): 3.2e-97 Smith-Waterman score: 1517; 53.0% identity (80.0% similar) in 419 aa overlap (1-418:1-415) 10 20 30 40 50 pF1KE4 MNNFGNE-EFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKAL :..: .. ... .:::: . ...:. . : . :.::.:.::: :.::: .: ... NP_001 MKGFIDDANYSVGLLDEGTNLGNVIDNYVYE-HTLTGKNAFFVGDLGKIVKKHSQWQNVV 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 PRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQ .. :::.::::.. :... ::: :::: :.::.:. ::: :::::: ::: .::::::: NP_001 AQIKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 IKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRL :::::. ::...: :.:.:: :.:: ::.::..:.:::.:. . . ..:::.::.. : NP_001 IKYAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRH 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 LLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFP ::: ::::.....::.:::.:.: . ...:.:.:::::::::..:.::.: .::::::: NP_001 LLECAKELDVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFT 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 GSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKE :.: ...::.. ::.: :: ::: :::.::.::: :::.:::::::::::::.: .. NP_001 GTE---FQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVEND 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 QTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPT . : .. :.: .::::.:::::::: : . .. : ..:. : :: ..::.:::. NP_001 KFPSGEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPS 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 CDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQ :: ::.::: : :::..::::..:.:::: . :.:: ::::.:::.:: : :: NP_001 CDELDQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSDWYEMQD 360 370 380 390 400 410 420 430 440 450 460 pF1KE4 FQNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV NP_001 AGITSDSMMKNFFFVPSCIQLSQEDSFSAEA 420 430 440 >>NP_001349941 (OMIM: 607909) antizyme inhibitor 1 isofo (447 aa) initn: 837 init1: 837 opt: 1517 Z-score: 1867.0 bits: 354.7 E(91964): 3.2e-97 Smith-Waterman score: 1517; 53.0% identity (80.0% similar) in 419 aa overlap (1-418:1-415) 10 20 30 40 50 pF1KE4 MNNFGNE-EFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKAL :..: .. ... .:::: . ...:. . : . :.::.:.::: :.::: .: ... NP_001 MKGFIDDANYSVGLLDEGTNLGNVIDNYVYE-HTLTGKNAFFVGDLGKIVKKHSQWQNVV 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 PRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQ .. :::.::::.. :... ::: :::: :.::.:. ::: :::::: ::: .::::::: NP_001 AQIKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 IKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRL :::::. ::...: :.:.:: :.:: ::.::..:.:::.:. . . ..:::.::.. : NP_001 IKYAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRH 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 LLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFP ::: ::::.....::.:::.:.: . ...:.:.:::::::::..:.::.: .::::::: NP_001 LLECAKELDVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFT 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 GSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKE :.: ...::.. ::.: :: ::: :::.::.::: :::.:::::::::::::.: .. NP_001 GTE---FQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVEND 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 QTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPT . : .. :.: .::::.:::::::: : . .. : ..:. : :: ..::.:::. NP_001 KFPSGEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPS 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 CDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQ :: ::.::: : :::..::::..:.:::: . :.:: ::::.:::.:: : :: NP_001 CDELDQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSDWYEMQD 360 370 380 390 400 410 420 430 440 450 460 pF1KE4 FQNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV NP_001 AGITSDSMMKNFFFVPSCIQLSQEDSFSAEA 420 430 440 >>NP_001349940 (OMIM: 607909) antizyme inhibitor 1 isofo (447 aa) initn: 837 init1: 837 opt: 1517 Z-score: 1867.0 bits: 354.7 E(91964): 3.2e-97 Smith-Waterman score: 1517; 53.0% identity (80.0% similar) in 419 aa overlap (1-418:1-415) 10 20 30 40 50 pF1KE4 MNNFGNE-EFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKAL :..: .. ... .:::: . ...:. . : . :.::.:.::: :.::: .: ... NP_001 MKGFIDDANYSVGLLDEGTNLGNVIDNYVYE-HTLTGKNAFFVGDLGKIVKKHSQWQNVV 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 PRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQ .. :::.::::.. :... ::: :::: :.::.:. ::: :::::: ::: .::::::: NP_001 AQIKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 IKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRL :::::. ::...: :.:.:: :.:: ::.::..:.:::.:. . . ..:::.::.. : NP_001 IKYAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRH 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 LLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFP ::: ::::.....::.:::.:.: . ...:.:.:::::::::..:.::.: .::::::: NP_001 LLECAKELDVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFT 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 GSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKE :.: ...::.. ::.: :: ::: :::.::.::: :::.:::::::::::::.: .. NP_001 GTE---FQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVEND 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 QTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPT . : .. :.: .::::.:::::::: : . .. : ..:. : :: ..::.:::. NP_001 KFPSGEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPS 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 CDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQ :: ::.::: : :::..::::..:.:::: . :.:: ::::.:::.:: : :: NP_001 CDELDQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSDWYEMQD 360 370 380 390 400 410 420 430 440 450 460 pF1KE4 FQNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV NP_001 AGITSDSMMKNFFFVPSCIQLSQEDSFSAEA 420 430 440 461 residues in 1 query sequences 65089639 residues in 91964 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Oct 12 17:02:24 2018 done: Fri Oct 12 17:02:25 2018 Total Scan time: 4.090 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]