FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4450, 468 aa 1>>>pF1KE4450 468 - 468 aa - 468 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.1148+/-0.000513; mu= 10.1562+/- 0.032 mean_var=236.4577+/-50.006, 0's: 0 Z-trim(114.3): 372 B-trim: 7 in 2/57 Lambda= 0.083406 statistics sampled from 23623 (24088) to 23623 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.641), E-opt: 0.2 (0.282), width: 16 Scan time: 9.250 The best scores are: opt bits E(85289) NP_001192273 (OMIM: 109770) carcinoembryonic antig ( 468) 3117 389.0 1.5e-107 NP_001703 (OMIM: 109770) carcinoembryonic antigen- ( 526) 3067 383.0 1e-105 NP_001020083 (OMIM: 109770) carcinoembryonic antig ( 464) 3063 382.5 1.4e-105 XP_011525508 (OMIM: 109770) PREDICTED: carcinoembr ( 351) 2162 273.9 5e-73 NP_001171744 (OMIM: 109770) carcinoembryonic antig ( 461) 2157 273.5 8.9e-73 NP_001171745 (OMIM: 109770) carcinoembryonic antig ( 368) 2147 272.1 1.8e-72 NP_001171742 (OMIM: 109770) carcinoembryonic antig ( 430) 2147 272.2 2e-72 XP_005258470 (OMIM: 114890) PREDICTED: carcinoembr ( 524) 2044 259.9 1.2e-68 NP_001278413 (OMIM: 114890) carcinoembryonic antig ( 702) 2044 260.1 1.4e-68 NP_004354 (OMIM: 114890) carcinoembryonic antigen- ( 702) 2044 260.1 1.4e-68 NP_001295327 (OMIM: 114890) carcinoembryonic antig ( 701) 2042 259.9 1.7e-68 XP_016881634 (OMIM: 114890) PREDICTED: carcinoembr ( 701) 2042 259.9 1.7e-68 XP_011524624 (OMIM: 114890) PREDICTED: carcinoembr ( 524) 2027 257.9 4.9e-68 NP_002474 (OMIM: 163980) carcinoembryonic antigen- ( 344) 1832 234.2 4.4e-61 XP_011525292 (OMIM: 163980) PREDICTED: carcinoembr ( 324) 1822 232.9 9.8e-61 NP_001807 (OMIM: 615747) carcinoembryonic antigen- ( 349) 1725 221.3 3.3e-57 XP_016881684 (OMIM: 615747) PREDICTED: carcinoembr ( 349) 1725 221.3 3.3e-57 XP_016881685 (OMIM: 615747) PREDICTED: carcinoembr ( 331) 1719 220.6 5.3e-57 XP_016881683 (OMIM: 615747) PREDICTED: carcinoembr ( 368) 1719 220.6 5.7e-57 XP_011524642 (OMIM: 615747) PREDICTED: carcinoembr ( 415) 1719 220.7 6.1e-57 XP_016881635 (OMIM: 114890) PREDICTED: carcinoembr ( 617) 1404 183.0 2e-45 XP_011524643 (OMIM: 615747) PREDICTED: carcinoembr ( 255) 1289 168.7 1.7e-41 XP_016881687 (OMIM: 615747) PREDICTED: carcinoembr ( 255) 1289 168.7 1.7e-41 XP_011524644 (OMIM: 615747) PREDICTED: carcinoembr ( 255) 1289 168.7 1.7e-41 XP_011525288 (OMIM: 176397) PREDICTED: pregnancy-s ( 326) 1259 165.2 2.4e-40 NP_001288637 (OMIM: 176398) pregnancy-specific bet ( 333) 1247 163.8 6.7e-40 XP_005259132 (OMIM: 176398) PREDICTED: pregnancy-s ( 402) 1247 163.9 7.5e-40 XP_011525428 (OMIM: 176392) PREDICTED: pregnancy-s ( 357) 1219 160.4 7.2e-39 NP_002772 (OMIM: 176394) pregnancy-specific beta-1 ( 335) 1218 160.3 7.6e-39 XP_016882492 (OMIM: 176394) PREDICTED: pregnancy-s ( 335) 1218 160.3 7.6e-39 NP_001123486 (OMIM: 176394) pregnancy-specific bet ( 335) 1218 160.3 7.6e-39 NP_112536 (OMIM: 176391) pregnancy-specific beta-1 ( 335) 1212 159.6 1.2e-38 NP_001288636 (OMIM: 176398) pregnancy-specific bet ( 333) 1210 159.3 1.5e-38 XP_016882494 (OMIM: 176398) PREDICTED: pregnancy-s ( 402) 1210 159.4 1.6e-38 NP_001263424 (OMIM: 176393) pregnancy-specific bet ( 326) 1204 158.6 2.4e-38 NP_998798 (OMIM: 176393) pregnancy-specific beta-1 ( 326) 1202 158.3 2.8e-38 XP_016882490 (OMIM: 176393) PREDICTED: pregnancy-s ( 333) 1202 158.3 2.9e-38 XP_016882491 (OMIM: 176393) PREDICTED: pregnancy-s ( 333) 1200 158.1 3.4e-38 XP_011525427 (OMIM: 176390) PREDICTED: pregnancy-s ( 333) 1198 157.9 4e-38 NP_001317453 (OMIM: 176390) pregnancy-specific bet ( 326) 1192 157.1 6.5e-38 XP_005259122 (OMIM: 176390) PREDICTED: pregnancy-s ( 333) 1190 156.9 7.8e-38 NP_002776 (OMIM: 176401) pregnancy-specific beta-1 ( 335) 1186 156.4 1.1e-37 XP_016882489 (OMIM: 176393) PREDICTED: pregnancy-s ( 342) 1124 149.0 1.9e-35 XP_016882487 (OMIM: 176393) PREDICTED: pregnancy-s ( 349) 1124 149.0 2e-35 XP_016882488 (OMIM: 176393) PREDICTED: pregnancy-s ( 349) 1122 148.7 2.3e-35 XP_016881686 (OMIM: 615747) PREDICTED: carcinoembr ( 295) 1015 135.8 1.6e-31 XP_011525429 (OMIM: 176392) PREDICTED: pregnancy-s ( 272) 908 122.9 1.1e-27 NP_001264092 (OMIM: 609142) carcinoembryonic antig ( 212) 792 108.7 1.6e-23 NP_001806 (OMIM: 609142) carcinoembryonic antigen- ( 252) 792 108.8 1.7e-23 NP_002773 (OMIM: 176395) pregnancy-specific beta-1 ( 435) 750 104.1 7.9e-22 >>NP_001192273 (OMIM: 109770) carcinoembryonic antigen-r (468 aa) initn: 3117 init1: 3117 opt: 3117 Z-score: 2051.8 bits: 389.0 E(85289): 1.5e-107 Smith-Waterman score: 3117; 100.0% identity (100.0% similar) in 468 aa overlap (1-468:1-468) 10 20 30 40 50 60 pF1KE4 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP 370 380 390 400 410 420 430 440 450 460 pF1KE4 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRTTPMTHLTR :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRTTPMTHLTR 430 440 450 460 >>NP_001703 (OMIM: 109770) carcinoembryonic antigen-rela (526 aa) initn: 3067 init1: 3067 opt: 3067 Z-score: 2018.8 bits: 383.0 E(85289): 1e-105 Smith-Waterman score: 3067; 98.7% identity (99.4% similar) in 467 aa overlap (1-467:1-467) 10 20 30 40 50 60 pF1KE4 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP 370 380 390 400 410 420 430 440 450 460 pF1KE4 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRTTPMTHLTR :::::::::::::::::::::::::::::::::::::::.. . :: NP_001 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRASDQRDLTEHKPSVSNHTQDH 430 440 450 460 470 480 NP_001 SNDPPNKMNEVTYSTLNFEAQQPTQPTSASPSLTATEIIYSEVKKQ 490 500 510 520 >>NP_001020083 (OMIM: 109770) carcinoembryonic antigen-r (464 aa) initn: 3389 init1: 3063 opt: 3063 Z-score: 2016.8 bits: 382.5 E(85289): 1.4e-105 Smith-Waterman score: 3063; 99.1% identity (99.6% similar) in 463 aa overlap (1-463:1-463) 10 20 30 40 50 60 pF1KE4 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP 370 380 390 400 410 420 430 440 450 460 pF1KE4 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRTTPMTHLTR :::::::::::::::::::::::::::::::::::::: . :. NP_001 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGSSGPLQ 430 440 450 460 >>XP_011525508 (OMIM: 109770) PREDICTED: carcinoembryoni (351 aa) initn: 2151 init1: 2151 opt: 2162 Z-score: 1432.1 bits: 273.9 E(85289): 5e-73 Smith-Waterman score: 2162; 98.2% identity (99.4% similar) in 329 aa overlap (1-329:1-328) 10 20 30 40 50 60 pF1KE4 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF :::::::::::::::::::: :::... . XP_011 ANNSVTGCNRTTVKTIIVTE-SPVLGEDEAVPGQHHPQHKPCQEGGCWDVLV 310 320 330 340 350 >>NP_001171744 (OMIM: 109770) carcinoembryonic antigen-r (461 aa) initn: 2419 init1: 2151 opt: 2157 Z-score: 1427.6 bits: 273.5 E(85289): 8.9e-73 Smith-Waterman score: 2320; 80.9% identity (83.5% similar) in 467 aa overlap (1-467:1-402) 10 20 30 40 50 60 pF1KE4 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF :::::::::::::::::::: . ::: NP_001 ANNSVTGCNRTTVKTIIVTERQ----------------------NLTM------------ 310 320 370 380 390 400 410 420 pF1KE4 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP :: : :... : ... : : .:: : . :::: NP_001 -----LP--------------------RLDSNS-WAQAILP-SVSQSAEI----TDNALP 330 340 350 430 440 450 460 pF1KE4 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRTTPMTHLTR :::::::::::::::::::::::::::::::::::::::.. . :: NP_001 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRASDQRDLTEHKPSVSNHTQDH 360 370 380 390 400 410 NP_001 SNDPPNKMNEVTYSTLNFEAQQPTQPTSASPSLTATEIIYSEVKKQ 420 430 440 450 460 >>NP_001171745 (OMIM: 109770) carcinoembryonic antigen-r (368 aa) initn: 2462 init1: 2147 opt: 2147 Z-score: 1422.1 bits: 272.1 E(85289): 1.8e-72 Smith-Waterman score: 2222; 78.2% identity (78.8% similar) in 463 aa overlap (1-463:1-367) 10 20 30 40 50 60 pF1KE4 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF :::::::::::::::::::. NP_001 ANNSVTGCNRTTVKTIIVTD---------------------------------------- 310 320 370 380 390 400 410 420 pF1KE4 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP :::: NP_001 --------------------------------------------------------NALP 430 440 450 460 pF1KE4 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRTTPMTHLTR :::::::::::::::::::::::::::::::::::::: . :. NP_001 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGSSGPLQ 330 340 350 360 >>NP_001171742 (OMIM: 109770) carcinoembryonic antigen-r (430 aa) initn: 2199 init1: 2147 opt: 2147 Z-score: 1421.4 bits: 272.2 E(85289): 2e-72 Smith-Waterman score: 2226; 77.9% identity (78.8% similar) in 467 aa overlap (1-467:1-371) 10 20 30 40 50 60 pF1KE4 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF :::::::::::::::::::. NP_001 ANNSVTGCNRTTVKTIIVTD---------------------------------------- 310 320 370 380 390 400 410 420 pF1KE4 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP :::: NP_001 --------------------------------------------------------NALP 430 440 450 460 pF1KE4 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRTTPMTHLTR :::::::::::::::::::::::::::::::::::::::.. . :: NP_001 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRASDQRDLTEHKPSVSNHTQDH 330 340 350 360 370 380 NP_001 SNDPPNKMNEVTYSTLNFEAQQPTQPTSASPSLTATEIIYSEVKKQ 390 400 410 420 430 >>XP_005258470 (OMIM: 114890) PREDICTED: carcinoembryoni (524 aa) initn: 2136 init1: 1809 opt: 2044 Z-score: 1353.5 bits: 259.9 E(85289): 1.2e-68 Smith-Waterman score: 2044; 73.0% identity (85.6% similar) in 423 aa overlap (5-427:5-422) 10 20 30 40 50 60 pF1KE4 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ ::: :: .::: :::::::::::::::::.:: :: ::::::::::::::::::: XP_005 MESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY .::::::::::::::::::.::.::::::::::: :::: :::::::::::. ::::::: XP_005 HLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI ::.:::::::::::::::.:::::::::::::::.::::::::::::::::::.:::::. XP_005 TLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP ::::::::::::::::::::::..::::::. :.:: :::::: ::: : ::: ::::.: XP_005 NNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH :::: .: :: : ::.:::.:::::::::::..::::::::::::::::::::::::::. XP_005 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF :.:: :: ::::: :: : : :: : ..... . :.:.: ::: . . . :. XP_005 AHNSDTGLNRTTVTTITVYAEPP---KPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWW 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP .::::: : :..::. : ::.. : :.:.: : : . : .: ..:::..::: :. : XP_005 VNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNELSVDHSDPVILNVLYG--P 360 370 380 390 400 410 430 440 450 460 pF1KE4 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRTTPMTHLTR .. .:: XP_005 DDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLY 420 430 440 450 460 470 >-- initn: 469 init1: 372 opt: 374 Z-score: 267.5 bits: 59.0 E(85289): 3.7e-08 Smith-Waterman score: 374; 76.0% identity (90.7% similar) in 75 aa overlap (245-319:423-497) 220 230 240 250 260 270 pF1KE4 CEIQNPVSANRSDPVTLNVTYGPDTPTISPSDTYYRPGANLSLSCYAASNPPAQYSWLIN : ::::::.::::::.:::::::::::::. XP_005 CGIQNELSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLID 400 410 420 430 440 450 280 290 300 310 320 330 pF1KE4 GTFQQSTQELFIPNITVNNSGSYTCHANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASK :..:: :::::: ::: .::: :::.::::..: .::::::: :. XP_005 GNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSASGTSPGLSAGATVG 460 470 480 490 500 510 340 350 360 370 380 390 pF1KE4 TTVTGDKDSVNLTCSTNDTGISIRWFFKNQSLPSSERMKLSQGNTTLSINPVKREDAGTY XP_005 IMIGVLVGVALI 520 >>NP_001278413 (OMIM: 114890) carcinoembryonic antigen-r (702 aa) initn: 2366 init1: 1809 opt: 2044 Z-score: 1352.2 bits: 260.1 E(85289): 1.4e-68 Smith-Waterman score: 2044; 73.0% identity (85.6% similar) in 423 aa overlap (5-427:5-422) 10 20 30 40 50 60 pF1KE4 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ ::: :: .::: :::::::::::::::::.:: :: ::::::::::::::::::: NP_001 MESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY .::::::::::::::::::.::.::::::::::: :::: :::::::::::. ::::::: NP_001 HLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI ::.:::::::::::::::.:::::::::::::::.::::::::::::::::::.:::::. NP_001 TLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP ::::::::::::::::::::::..::::::. :.:: :::::: ::: : ::: ::::.: NP_001 NNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH :::: .: :: : ::.:::.:::::::::::..::::::::::::::::::::::::::. NP_001 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF :.:: :: ::::: :: : : :: : ..... . :.:.: ::: . . . :. NP_001 AHNSDTGLNRTTVTTITVYAEPP---KPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWW 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP .::::: : :..::. : ::.. : :.:.: : : . : .: ..:::..::: :. : NP_001 VNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNELSVDHSDPVILNVLYG--P 360 370 380 390 400 410 430 440 450 460 pF1KE4 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRTTPMTHLTR .. .:: NP_001 DDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLY 420 430 440 450 460 470 >-- initn: 1292 init1: 855 opt: 899 Z-score: 607.6 bits: 122.3 E(85289): 4.2e-27 Smith-Waterman score: 899; 65.0% identity (82.7% similar) in 214 aa overlap (107-319:462-675) 80 90 100 110 120 130 pF1KE4 RQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFYTLQVIKSDLVNEEATG :.:.:.:....:.:: :. .: . ..: NP_001 NLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTV 440 450 460 470 480 490 140 150 160 170 180 190 pF1KE4 Q-FHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWINNQSLPVSPRLQLSN . . : ::::::::::::.:::::::::::::::.:.::::::.:.::::::::::::: NP_001 KTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSN 500 510 520 530 540 550 200 210 220 230 240 250 pF1KE4 GNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTPTISPSDTYYRPGANL :::::::..:::::. : : ::: :::::::::::.: :::::: ::: :. : :::: NP_001 GNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANL 560 570 580 590 600 610 260 270 280 290 300 310 pF1KE4 SLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCHANNSVTGCNRTTVKT .:::..:::: :::: ::: :: :: ::: .:: ::.:.:.: ..: .:: : . ::. NP_001 NLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKS 620 630 640 650 660 670 320 330 340 350 360 370 pF1KE4 IIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWFFKNQSLPSSERMKLS : :. NP_001 ITVSASGTSPGLSAGATVGIMIGVLVGVALI 680 690 700 >>NP_004354 (OMIM: 114890) carcinoembryonic antigen-rela (702 aa) initn: 2366 init1: 1809 opt: 2044 Z-score: 1352.2 bits: 260.1 E(85289): 1.4e-68 Smith-Waterman score: 2044; 73.0% identity (85.6% similar) in 423 aa overlap (5-427:5-422) 10 20 30 40 50 60 pF1KE4 MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ ::: :: .::: :::::::::::::::::.:: :: ::::::::::::::::::: NP_004 MESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY .::::::::::::::::::.::.::::::::::: :::: :::::::::::. ::::::: NP_004 HLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI ::.:::::::::::::::.:::::::::::::::.::::::::::::::::::.:::::. NP_004 TLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP ::::::::::::::::::::::..::::::. :.:: :::::: ::: : ::: ::::.: NP_004 NNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH :::: .: :: : ::.:::.:::::::::::..::::::::::::::::::::::::::. NP_004 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF :.:: :: ::::: :: : : :: : ..... . :.:.: ::: . . . :. NP_004 AHNSDTGLNRTTVTTITVYAEPP---KPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWW 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP .::::: : :..::. : ::.. : :.:.: : : . : .: ..:::..::: :. : NP_004 VNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNELSVDHSDPVILNVLYG--P 360 370 380 390 400 410 430 440 450 460 pF1KE4 QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRTTPMTHLTR .. .:: NP_004 DDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLY 420 430 440 450 460 470 >-- initn: 1292 init1: 855 opt: 899 Z-score: 607.6 bits: 122.3 E(85289): 4.2e-27 Smith-Waterman score: 899; 65.0% identity (82.7% similar) in 214 aa overlap (107-319:462-675) 80 90 100 110 120 130 pF1KE4 RQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFYTLQVIKSDLVNEEATG :.:.:.:....:.:: :. .: . ..: NP_004 NLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTV 440 450 460 470 480 490 140 150 160 170 180 190 pF1KE4 Q-FHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWINNQSLPVSPRLQLSN . . : ::::::::::::.:::::::::::::::.:.::::::.:.::::::::::::: NP_004 KTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSN 500 510 520 530 540 550 200 210 220 230 240 250 pF1KE4 GNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTPTISPSDTYYRPGANL :::::::..:::::. : : ::: :::::::::::.: :::::: ::: :. : :::: NP_004 GNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANL 560 570 580 590 600 610 260 270 280 290 300 310 pF1KE4 SLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCHANNSVTGCNRTTVKT .:::..:::: :::: ::: :: :: ::: .:: ::.:.:.: ..: .:: : . ::. NP_004 NLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKS 620 630 640 650 660 670 320 330 340 350 360 370 pF1KE4 IIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWFFKNQSLPSSERMKLS : :. NP_004 ITVSASGTSPGLSAGATVGIMIGVLVGVALI 680 690 700 468 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:03:47 2016 done: Sun Nov 6 01:03:48 2016 Total Scan time: 9.250 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]