Result of FASTA (omim) for
pF1KE4483
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4483, 500 aa
1>>>pF1KE4483 500 - 500 aa - 500 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0544+/-0.000389; mu= 19.4643+/- 0.024
mean_var=68.8630+/-13.780, 0's: 0 Z-trim(112.3): 39 B-trim: 5 in 1/53
Lambda= 0.154554
statistics sampled from 21173 (21211) to 21173 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.621), E-opt: 0.2 (0.249), width: 16
Scan time: 8.490
The best scores are: opt bits E(85289)
NP_006024 (OMIM: 603684) endothelial lipase isofor ( 500) 3444 777.4 0
XP_005258447 (OMIM: 603684) PREDICTED: endothelial ( 536) 3206 724.3 2.1e-208
XP_011524569 (OMIM: 603684) PREDICTED: endothelial ( 420) 2865 648.2 1.3e-185
XP_016881584 (OMIM: 603684) PREDICTED: endothelial ( 303) 2071 471.1 2e-132
NP_001294935 (OMIM: 603684) endothelial lipase iso ( 426) 1603 366.8 6.9e-101
XP_011524567 (OMIM: 603684) PREDICTED: endothelial ( 462) 1603 366.8 7.4e-101
NP_000228 (OMIM: 144250,238600,609708) lipoprotein ( 475) 1501 344.1 5.3e-94
XP_005254431 (OMIM: 125853,151670,612797,614025) P ( 511) 1390 319.4 1.6e-86
NP_000227 (OMIM: 125853,151670,612797,614025) hepa ( 499) 1389 319.1 1.8e-86
XP_005254429 (OMIM: 125853,151670,612797,614025) P ( 499) 1389 319.1 1.8e-86
XP_006720565 (OMIM: 125853,151670,612797,614025) P ( 452) 1378 316.7 9.2e-86
XP_016877665 (OMIM: 125853,151670,612797,614025) P ( 398) 1075 249.1 1.8e-65
NP_000927 (OMIM: 246600,614338) pancreatic triacyl ( 465) 702 165.9 2.2e-40
NP_005387 (OMIM: 604423) pancreatic lipase-related ( 470) 684 161.9 3.6e-39
XP_011538170 (OMIM: 604422) PREDICTED: inactive pa ( 467) 668 158.4 4.3e-38
NP_006220 (OMIM: 604422) inactive pancreatic lipas ( 467) 668 158.4 4.3e-38
NP_001290064 (OMIM: 604422) inactive pancreatic li ( 467) 668 158.4 4.3e-38
XP_016871828 (OMIM: 604423) PREDICTED: pancreatic ( 249) 532 127.8 3.5e-29
XP_006724028 (OMIM: 145750,609252) PREDICTED: lipa ( 404) 512 123.5 1.1e-27
NP_001289927 (OMIM: 145750,609252) lipase member I ( 460) 512 123.6 1.2e-27
NP_945347 (OMIM: 145750,609252) lipase member I is ( 481) 512 123.6 1.3e-27
NP_640341 (OMIM: 604379,607365) lipase member H pr ( 451) 506 122.2 3.1e-27
NP_056984 (OMIM: 607460) phospholipase A1 member A ( 456) 506 122.2 3.1e-27
NP_001289930 (OMIM: 145750,609252) lipase member I ( 375) 505 121.9 3.1e-27
XP_011510833 (OMIM: 604379,607365) PREDICTED: lipa ( 408) 504 121.7 3.9e-27
XP_011510832 (OMIM: 604379,607365) PREDICTED: lipa ( 408) 504 121.7 3.9e-27
NP_001289929 (OMIM: 145750,609252) lipase member I ( 454) 495 119.8 1.7e-26
XP_011538171 (OMIM: 604422) PREDICTED: inactive pa ( 318) 486 117.7 5.2e-26
NP_001280154 (OMIM: 607460) phospholipase A1 membe ( 440) 487 118.0 5.7e-26
XP_006713592 (OMIM: 604379,607365) PREDICTED: lipa ( 421) 410 100.8 8.2e-21
NP_001289928 (OMIM: 145750,609252) lipase member I ( 430) 374 92.8 2.2e-18
NP_001193889 (OMIM: 607460) phospholipase A1 membe ( 440) 351 87.7 7.7e-17
NP_001193890 (OMIM: 607460) phospholipase A1 membe ( 283) 274 70.3 8.1e-12
XP_016862061 (OMIM: 607460) PREDICTED: phospholipa ( 283) 274 70.3 8.1e-12
XP_016861341 (OMIM: 604379,607365) PREDICTED: lipa ( 417) 270 69.6 2e-11
>>NP_006024 (OMIM: 603684) endothelial lipase isoform 1 (500 aa)
initn: 3444 init1: 3444 opt: 3444 Z-score: 4149.8 bits: 777.4 E(85289): 0
Smith-Waterman score: 3444; 99.6% identity (99.8% similar) in 500 aa overlap (1-500:1-500)
10 20 30 40 50 60
pF1KE4 MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 QSWYNLWKEFRSYLSQPRNPGREPNIRRIRVKSGETQRKLTFCTEDPENTSISPGQELWF
::::::::::::::::::::::: :::::::::::::::::::::::::::::::.::::
NP_006 QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
430 440 450 460 470 480
490 500
pF1KE4 RKCRDGWRMKNETSPTVELP
::::::::::::::::::::
NP_006 RKCRDGWRMKNETSPTVELP
490 500
>>XP_005258447 (OMIM: 603684) PREDICTED: endothelial lip (536 aa)
initn: 3204 init1: 3204 opt: 3206 Z-score: 3862.5 bits: 724.3 E(85289): 2.1e-208
Smith-Waterman score: 3206; 98.5% identity (98.9% similar) in 476 aa overlap (26-500:61-536)
10 20 30 40 50
pF1KE4 MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRL-EDKLHKPKATQTEVKPSVRFNLR
:: : .::::::::::::::::::::::
XP_005 GGSGCPEEGSGRKLELLESQLPAERAREEAGPSVRRPRDKLHKPKATQTEVKPSVRFNLR
40 50 60 70 80 90
60 70 80 90 100 110
pF1KE4 TSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREK
100 110 120 130 140 150
120 130 140 150 160 170
pF1KE4 DANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHV
160 170 180 190 200 210
180 190 200 210 220 230
pF1KE4 AGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQM
220 230 240 250 260 270
240 250 260 270 280 290
pF1KE4 PVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFA
280 290 300 310 320 330
300 310 320 330 340 350
pF1KE4 FQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIH
340 350 360 370 380 390
360 370 380 390 400 410
pF1KE4 VFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQL
400 410 420 430 440 450
420 430 440 450 460 470
pF1KE4 TWEGASQSWYNLWKEFRSYLSQPRNPGREPNIRRIRVKSGETQRKLTFCTEDPENTSISP
::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::
XP_005 TWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISP
460 470 480 490 500 510
480 490 500
pF1KE4 GQELWFRKCRDGWRMKNETSPTVELP
:.::::::::::::::::::::::::
XP_005 GRELWFRKCRDGWRMKNETSPTVELP
520 530
>>XP_011524569 (OMIM: 603684) PREDICTED: endothelial lip (420 aa)
initn: 2865 init1: 2865 opt: 2865 Z-score: 3453.1 bits: 648.2 E(85289): 1.3e-185
Smith-Waterman score: 2865; 99.5% identity (99.8% similar) in 420 aa overlap (81-500:1-420)
60 70 80 90 100 110
pF1KE4 FNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALH
::::::::::::::::::::::::::::::
XP_011 MTAKTFFIIHGWTMSGIFENWLHKLVSALH
10 20 30
120 130 140 150 160 170
pF1KE4 TREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSL
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE4 GAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSI
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE4 GIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDK
160 170 180 190 200 210
300 310 320 330 340 350
pF1KE4 PSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQ
220 230 240 250 260 270
360 370 380 390 400 410
pF1KE4 MKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLL
280 290 300 310 320 330
420 430 440 450 460 470
pF1KE4 KIQLTWEGASQSWYNLWKEFRSYLSQPRNPGREPNIRRIRVKSGETQRKLTFCTEDPENT
::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
XP_011 KIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENT
340 350 360 370 380 390
480 490 500
pF1KE4 SISPGQELWFRKCRDGWRMKNETSPTVELP
:::::.::::::::::::::::::::::::
XP_011 SISPGRELWFRKCRDGWRMKNETSPTVELP
400 410 420
>>XP_016881584 (OMIM: 603684) PREDICTED: endothelial lip (303 aa)
initn: 2071 init1: 2071 opt: 2071 Z-score: 2498.3 bits: 471.1 E(85289): 2e-132
Smith-Waterman score: 2071; 99.3% identity (99.7% similar) in 303 aa overlap (198-500:1-303)
170 180 190 200 210 220
pF1KE4 YSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFG
::::::::::::::::::::::::::::::
XP_016 MFEGADIHKRLSPDDADFVDVLHTYTRSFG
10 20 30
230 240 250 260 270 280
pF1KE4 LSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVN
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE4 QDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVY
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE4 HYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLG
160 170 180 190 200 210
410 420 430 440 450 460
pF1KE4 DLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGREPNIRRIRVKSGETQRKLTFCTEDP
:::::::::::::::::::::::::::::::::::: :::::::::::::::::::::::
XP_016 DLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDP
220 230 240 250 260 270
470 480 490 500
pF1KE4 ENTSISPGQELWFRKCRDGWRMKNETSPTVELP
::::::::.::::::::::::::::::::::::
XP_016 ENTSISPGRELWFRKCRDGWRMKNETSPTVELP
280 290 300
>>NP_001294935 (OMIM: 603684) endothelial lipase isoform (426 aa)
initn: 1595 init1: 1595 opt: 1603 Z-score: 1932.2 bits: 366.8 E(85289): 6.9e-101
Smith-Waterman score: 2756; 84.6% identity (85.0% similar) in 500 aa overlap (1-500:1-426)
10 20 30 40 50 60
pF1KE4 MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
::::::::::.
NP_001 FVKGTVGRITA-------------------------------------------------
190
250 260 270 280 290 300
pF1KE4 IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
:::::::::::::::::::::::::::::::::::
NP_001 -------------------------ITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
200 210 220
310 320 330 340 350 360
pF1KE4 NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
230 240 250 260 270 280
370 380 390 400 410 420
pF1KE4 MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
290 300 310 320 330 340
430 440 450 460 470 480
pF1KE4 QSWYNLWKEFRSYLSQPRNPGREPNIRRIRVKSGETQRKLTFCTEDPENTSISPGQELWF
::::::::::::::::::::::: :::::::::::::::::::::::::::::::.::::
NP_001 QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
350 360 370 380 390 400
490 500
pF1KE4 RKCRDGWRMKNETSPTVELP
::::::::::::::::::::
NP_001 RKCRDGWRMKNETSPTVELP
410 420
>>XP_011524567 (OMIM: 603684) PREDICTED: endothelial lip (462 aa)
initn: 1595 init1: 1595 opt: 1603 Z-score: 1931.7 bits: 366.8 E(85289): 7.4e-101
Smith-Waterman score: 2518; 82.8% identity (83.4% similar) in 476 aa overlap (26-500:61-462)
10 20 30 40 50
pF1KE4 MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRL-EDKLHKPKATQTEVKPSVRFNLR
:: : .::::::::::::::::::::::
XP_011 GGSGCPEEGSGRKLELLESQLPAERAREEAGPSVRRPRDKLHKPKATQTEVKPSVRFNLR
40 50 60 70 80 90
60 70 80 90 100 110
pF1KE4 TSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREK
100 110 120 130 140 150
120 130 140 150 160 170
pF1KE4 DANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHV
160 170 180 190 200 210
180 190 200 210 220 230
pF1KE4 AGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQM
::::::::::::::::.
XP_011 AGYAGNFVKGTVGRITA-------------------------------------------
220
240 250 260 270 280 290
pF1KE4 PVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFA
:::::::::::::::::::::::::::::
XP_011 -------------------------------ITEVVKCEHERAVHLFVDSLVNQDKPSFA
230 240 250
300 310 320 330 340 350
pF1KE4 FQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIH
260 270 280 290 300 310
360 370 380 390 400 410
pF1KE4 VFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQL
320 330 340 350 360 370
420 430 440 450 460 470
pF1KE4 TWEGASQSWYNLWKEFRSYLSQPRNPGREPNIRRIRVKSGETQRKLTFCTEDPENTSISP
::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::
XP_011 TWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISP
380 390 400 410 420 430
480 490 500
pF1KE4 GQELWFRKCRDGWRMKNETSPTVELP
:.::::::::::::::::::::::::
XP_011 GRELWFRKCRDGWRMKNETSPTVELP
440 450 460
>>NP_000228 (OMIM: 144250,238600,609708) lipoprotein lip (475 aa)
initn: 1482 init1: 674 opt: 1501 Z-score: 1808.6 bits: 344.1 E(85289): 5.3e-94
Smith-Waterman score: 1503; 49.1% identity (77.6% similar) in 442 aa overlap (50-485:40-467)
20 30 40 50 60 70
pF1KE4 GSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSF
.: ::: .: .. :.: : .. . : :
NP_000 TLAVWLQSLTASRGGVAAADQRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHF
10 20 30 40 50 60
80 90 100 110 120 130
pF1KE4 NMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTR
: ..:::..:::::..:..:.:. :::.::. :: :.::.::::: :.. : ... :.
NP_000 NHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTK
70 80 90 100 110 120
140 150 160 170 180 190
pF1KE4 VVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMF
.::...::...:..:. .. : ::::.:::::::.:: ::.... :.:::::::::: :
NP_000 LVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNF
130 140 150 160 170 180
200 210 220 230 240 250
pF1KE4 EGADIHKRLSPDDADFVDVLHTYTR-SFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVL
: :. .:::::::::::::::.:: : : ::::: ::::.::::::: :::::......
NP_000 EYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAI
190 200 210 220 230 240
260 270 280 290 300 310
pF1KE4 GSIA---YGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCRKNR
:: : . ..::: :::..:::.:::.:...:: :..:.... :.::.::::::::
NP_000 RVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNR
250 260 270 280 290 300
320 330 340 350 360 370
pF1KE4 CNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGT
::..::. .:.: ::.::::::::. ::..:.:::.::: . .. . . .: ..::::
NP_000 CNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGT
310 320 330 340 350 360
380 390 400 410 420 430
pF1KE4 NADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGASQ-SWYNLWKEFRSYL
:.:...:. . : . : : .::.::: :.:.:: ..: :.. : :: . :.
NP_000 VAESENIPFTLPE-VSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWS------
370 380 390 400 410 420
440 450 460 470 480 490
pF1KE4 SQPRNPGREPNIRRIRVKSGETQRKLTFCTEDPENTSISPGQE-LWFRKCRDGWRMKNET
.:: :..::::.::::.:. ::... . . .. :. : ::.:
NP_000 ----SPGF--AIQKIRVKAGETQKKVIFCSRE-KVSHLQKGKAPAVFVKCHDKSLNKKSG
430 440 450 460 470
500
pF1KE4 SPTVELP
>>XP_005254431 (OMIM: 125853,151670,612797,614025) PREDI (511 aa)
initn: 1292 init1: 358 opt: 1390 Z-score: 1674.4 bits: 319.4 E(85289): 1.6e-86
Smith-Waterman score: 1390; 43.6% identity (72.5% similar) in 484 aa overlap (21-494:37-506)
10 20 30 40 50
pF1KE4 MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVR
.:: : :: . .. : : :.: .:
XP_005 LNLIFLLLKPQYHPQILITGVTTSSEDMRKAPVSEEPFGRRAQAVETNK-TLHEMK--TR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 FNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALH
: : . .:: . ..: . :..:.:: . .:::::...:..:::. ..:.::.
XP_005 FLLFGETN---QGCQIRINHPDTLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALK
70 80 90 100 110 120
120 130 140 150 160
pF1KE4 TRE-KDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYS
.. . .:: .:::. :::. :: :: :::.::. .: .: ::.:. ..: ..:::::::
XP_005 SQPAQPVNVGLVDWITLAHDHYTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYS
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE4 LGAHVAGYAGNFVKGT--VGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRS-F
:::::.:.::. . :: .::::::: :::.:::. .:::::::.:::..::.:: .
XP_005 LGAHVSGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHM
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE4 GLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIA---YGTITEVVKCEHERAVHLFVD
:::.::..:.:: :.:::::.::::: . .. :: ...::...:: :::.::::.:
XP_005 GLSVGIKQPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFID
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE4 SLVNQDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMP
::.. :.:. : : : :..:.::::.:.:::..::.... .......: ::: :
XP_005 SLLHAGTQSMAYPCGDMNSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSP
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE4 FRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTE
:.:::::.::. : .. :. :: ..: ::. : .:. . . : .: : .::. .
XP_005 FKVYHYQFKIQ-FINQTETPIQTTFTMSLLGTKEKMQKIPITLGKGIASNKTYSFLITLD
370 380 390 400 410
410 420 430 440 450 460
pF1KE4 EDLGDLLKIQLTWEGASQSWYNLWKEFRSYL---SQPRNPGREPNIRRIRVKSGETQRKL
:.:.:. :.. ::. : : :.: .. . . ::. : .. ::::.::::...
XP_005 VDIGELIMIKFKWEN-SAVWANVWDTVQTIIPWSTGPRHSGLV--LKTIRVKAGETQQRM
420 430 440 450 460 470
470 480 490 500
pF1KE4 TFCTEDPENTSISPGQELWFRKCRDGWRMKNETSPTVELP
:::.:. .. . : :: : ::. .:..::
XP_005 TFCSENTDDLLLRPTQEKIFVKCE----IKSKTSKRKIR
480 490 500 510
>>NP_000227 (OMIM: 125853,151670,612797,614025) hepatic (499 aa)
initn: 1295 init1: 358 opt: 1389 Z-score: 1673.4 bits: 319.1 E(85289): 1.8e-86
Smith-Waterman score: 1389; 42.9% identity (71.2% similar) in 503 aa overlap (8-494:6-494)
10 20 30 40 50
pF1KE4 MSNSVPLLCF---WSLCYCF---AAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLR
::: :: . : :. . : :: . .. : : :.: .:: :
NP_000 MDTSPLCFSILLVLCIFIQSSALGQSLKPEPFGRRAQAVETNK-TLHEMK--TRFLLF
10 20 30 40 50
60 70 80 90 100 110
pF1KE4 TSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTRE-
..:: . ..: . :..:.:: . .:::::...:..:::. ..:.::...
NP_000 ---GETNQGCQIRINHPDTLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPA
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 KDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAH
. .:: .:::. :::. :: :: :::.::. .: .: ::.:. ..: ..:::::::::::
NP_000 QPVNVGLVDWITLAHDHYTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYSLGAH
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 VAGYAGNFVKGT--VGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRS-FGLSI
:.:.::. . :: .::::::: :::.:::. .:::::::.:::..::.:: .:::.
NP_000 VSGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSV
180 190 200 210 220 230
240 250 260 270 280
pF1KE4 GIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIA---YGTITEVVKCEHERAVHLFVDSLVN
::..:.:: :.:::::.::::: . .. :: ...::...:: :::.::::.:::..
NP_000 GIKQPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLH
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 QDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVY
:.:. : : : :..:.::::.:.:::..::.... .......: ::: ::.::
NP_000 AGTQSMAYPCGDMNSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSPFKVY
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 HYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLG
:::.::. : .. :. :: ..: ::. : .:. . . : .: : .::. . :.:
NP_000 HYQFKIQ-FINQTETPIQTTFTMSLLGTKEKMQKIPITLGKGIASNKTYSFLITLDVDIG
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE4 DLLKIQLTWEGASQSWYNLWKEFRSYL---SQPRNPGREPNIRRIRVKSGETQRKLTFCT
.:. :.. ::. : : :.: .. . . ::. : .. ::::.::::...:::.
NP_000 ELIMIKFKWEN-SAVWANVWDTVQTIIPWSTGPRHSGL--VLKTIRVKAGETQQRMTFCS
420 430 440 450 460
470 480 490 500
pF1KE4 EDPENTSISPGQELWFRKCRDGWRMKNETSPTVELP
:. .. . : :: : ::. .:..::
NP_000 ENTDDLLLRPTQEKIFVKCE----IKSKTSKRKIR
470 480 490
>>XP_005254429 (OMIM: 125853,151670,612797,614025) PREDI (499 aa)
initn: 1295 init1: 358 opt: 1389 Z-score: 1673.4 bits: 319.1 E(85289): 1.8e-86
Smith-Waterman score: 1389; 42.9% identity (71.2% similar) in 503 aa overlap (8-494:6-494)
10 20 30 40 50
pF1KE4 MSNSVPLLCF---WSLCYCF---AAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLR
::: :: . : :. . : :: . .. : : :.: .:: :
XP_005 MDTSPLCFSILLVLCIFIQSSALGQSLKPEPFGRRAQAVETNK-TLHEMK--TRFLLF
10 20 30 40 50
60 70 80 90 100 110
pF1KE4 TSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTRE-
..:: . ..: . :..:.:: . .:::::...:..:::. ..:.::...
XP_005 ---GETNQGCQIRINHPDTLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPA
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 KDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAH
. .:: .:::. :::. :: :: :::.::. .: .: ::.:. ..: ..:::::::::::
XP_005 QPVNVGLVDWITLAHDHYTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYSLGAH
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 VAGYAGNFVKGT--VGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRS-FGLSI
:.:.::. . :: .::::::: :::.:::. .:::::::.:::..::.:: .:::.
XP_005 VSGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSV
180 190 200 210 220 230
240 250 260 270 280
pF1KE4 GIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIA---YGTITEVVKCEHERAVHLFVDSLVN
::..:.:: :.:::::.::::: . .. :: ...::...:: :::.::::.:::..
XP_005 GIKQPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLH
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 QDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVY
:.:. : : : :..:.::::.:.:::..::.... .......: ::: ::.::
XP_005 AGTQSMAYPCGDMNSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSPFKVY
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 HYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLG
:::.::. : .. :. :: ..: ::. : .:. . . : .: : .::. . :.:
XP_005 HYQFKIQ-FINQTETPIQTTFTMSLLGTKEKMQKIPITLGKGIASNKTYSFLITLDVDIG
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE4 DLLKIQLTWEGASQSWYNLWKEFRSYL---SQPRNPGREPNIRRIRVKSGETQRKLTFCT
.:. :.. ::. : : :.: .. . . ::. : .. ::::.::::...:::.
XP_005 ELIMIKFKWEN-SAVWANVWDTVQTIIPWSTGPRHSGL--VLKTIRVKAGETQQRMTFCS
420 430 440 450 460
470 480 490 500
pF1KE4 EDPENTSISPGQELWFRKCRDGWRMKNETSPTVELP
:. .. . : :: : ::. .:..::
XP_005 ENTDDLLLRPTQEKIFVKCE----IKSKTSKRKIR
470 480 490
500 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 00:51:43 2016 done: Sun Nov 6 00:51:45 2016
Total Scan time: 8.490 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]