FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4539, 622 aa 1>>>pF1KE4539 622 - 622 aa - 622 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7366+/-0.000326; mu= 18.3068+/- 0.020 mean_var=94.5394+/-19.232, 0's: 0 Z-trim(117.4): 32 B-trim: 0 in 0/54 Lambda= 0.131907 statistics sampled from 29413 (29445) to 29413 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.71), E-opt: 0.2 (0.345), width: 16 Scan time: 12.640 The best scores are: opt bits E(85289) NP_001170826 (OMIM: 601051) mesothelin isoform 1 p ( 622) 4145 799.2 0 NP_005814 (OMIM: 601051) mesothelin isoform 1 prep ( 622) 4145 799.2 0 XP_016878344 (OMIM: 601051) PREDICTED: mesothelin ( 632) 4145 799.2 0 XP_005255091 (OMIM: 601051) PREDICTED: mesothelin ( 621) 4127 795.8 0 XP_016878345 (OMIM: 601051) PREDICTED: mesothelin ( 631) 4127 795.8 0 XP_016878346 (OMIM: 601051) PREDICTED: mesothelin ( 630) 4119 794.3 0 XP_011520650 (OMIM: 601051) PREDICTED: mesothelin ( 630) 4119 794.3 0 NP_037536 (OMIM: 601051) mesothelin isoform 2 prep ( 630) 4119 794.3 0 XP_016878342 (OMIM: 601051) PREDICTED: mesothelin ( 640) 4119 794.3 0 XP_016878347 (OMIM: 601051) PREDICTED: mesothelin ( 629) 4101 790.9 0 XP_016878343 (OMIM: 601051) PREDICTED: mesothelin ( 639) 4101 790.9 0 XP_011544050 (OMIM: 607038,607039) PREDICTED: otoa ( 798) 209 50.3 3.1e-05 NP_733764 (OMIM: 607038,607039) otoancorin isoform ( 815) 209 50.3 3.1e-05 NP_001155155 (OMIM: 607038,607039) otoancorin isof (1060) 209 50.4 3.8e-05 NP_653273 (OMIM: 607038,607039) otoancorin isoform (1139) 209 50.4 4e-05 XP_011544049 (OMIM: 607038,607039) PREDICTED: otoa (1139) 209 50.4 4e-05 XP_016878439 (OMIM: 607038,607039) PREDICTED: otoa (1142) 209 50.4 4.1e-05 XP_016878440 (OMIM: 607038,607039) PREDICTED: otoa ( 597) 189 46.4 0.00035 >>NP_001170826 (OMIM: 601051) mesothelin isoform 1 prepr (622 aa) initn: 4145 init1: 4145 opt: 4145 Z-score: 4264.5 bits: 799.2 E(85289): 0 Smith-Waterman score: 4145; 99.8% identity (99.8% similar) in 622 aa overlap (1-622:1-622) 10 20 30 40 50 60 pF1KE4 MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDGVLANPPNISS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDGVLANPPNISS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 DVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTW 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 SVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 ACPSGKKAPEIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELY :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 PQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQVATLIDRFVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQVATLIDRFVK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 GRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 RLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 KLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLSMQEALSGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLSMQEALSGT 550 560 570 580 590 600 610 620 pF1KE4 PCLLGPGPVLTVLALLLASTLA :::::::::::::::::::::: NP_001 PCLLGPGPVLTVLALLLASTLA 610 620 >>NP_005814 (OMIM: 601051) mesothelin isoform 1 prepropr (622 aa) initn: 4145 init1: 4145 opt: 4145 Z-score: 4264.5 bits: 799.2 E(85289): 0 Smith-Waterman score: 4145; 99.8% identity (99.8% similar) in 622 aa overlap (1-622:1-622) 10 20 30 40 50 60 pF1KE4 MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDGVLANPPNISS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDGVLANPPNISS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 DVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTW 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 SVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 ACPSGKKAPEIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELY :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 PQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQVATLIDRFVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQVATLIDRFVK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 GRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 RLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 KLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLSMQEALSGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLSMQEALSGT 550 560 570 580 590 600 610 620 pF1KE4 PCLLGPGPVLTVLALLLASTLA :::::::::::::::::::::: NP_005 PCLLGPGPVLTVLALLLASTLA 610 620 >>XP_016878344 (OMIM: 601051) PREDICTED: mesothelin isof (632 aa) initn: 4145 init1: 4145 opt: 4145 Z-score: 4264.4 bits: 799.2 E(85289): 0 Smith-Waterman score: 4145; 99.8% identity (99.8% similar) in 622 aa overlap (1-622:11-632) 10 20 30 40 50 pF1KE4 MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDG :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVASLKGTQTMALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 VLANPPNISSLSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLANPPNISSLSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 PPEDLDALPLDLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPEDLDALPLDLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACW 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 GVRGSLLSEADVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVRGSLLSEADVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGG 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 GPPYGPPSTWSVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPPYGPPSTWSVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILR 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE4 PRFRREVEKTACPSGKKAPEIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLD :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_016 PRFRREVEKTACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLD 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE4 VLKHKLDELYPQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLKHKLDELYPQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQ 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE4 VATLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VATLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE4 RQLDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQLDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDA 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE4 VLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLD 550 560 570 580 590 600 600 610 620 pF1KE4 LSMQEALSGTPCLLGPGPVLTVLALLLASTLA :::::::::::::::::::::::::::::::: XP_016 LSMQEALSGTPCLLGPGPVLTVLALLLASTLA 610 620 630 >>XP_005255091 (OMIM: 601051) PREDICTED: mesothelin isof (621 aa) initn: 3853 init1: 3853 opt: 4127 Z-score: 4246.0 bits: 795.8 E(85289): 0 Smith-Waterman score: 4127; 99.7% identity (99.7% similar) in 622 aa overlap (1-622:1-621) 10 20 30 40 50 60 pF1KE4 MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDGVLANPPNISS ::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::: XP_005 MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQ-AAPLDGVLANPPNISS 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 LSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 DLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEA 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 DVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTW 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 SVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKT 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 ACPSGKKAPEIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELY :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELY 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 PQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQVATLIDRFVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQVATLIDRFVK 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE4 GRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKA 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE4 RLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQ 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE4 KLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLSMQEALSGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLSMQEALSGT 540 550 560 570 580 590 610 620 pF1KE4 PCLLGPGPVLTVLALLLASTLA :::::::::::::::::::::: XP_005 PCLLGPGPVLTVLALLLASTLA 600 610 620 >>XP_016878345 (OMIM: 601051) PREDICTED: mesothelin isof (631 aa) initn: 3853 init1: 3853 opt: 4127 Z-score: 4245.9 bits: 795.8 E(85289): 0 Smith-Waterman score: 4127; 99.7% identity (99.7% similar) in 622 aa overlap (1-622:11-631) 10 20 30 40 50 pF1KE4 MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDG ::::::::::::::::::::::::::::::::::::::::::: :::::: XP_016 MVASLKGTQTMALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQ-AAPLDG 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 VLANPPNISSLSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLANPPNISSLSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 PPEDLDALPLDLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPEDLDALPLDLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACW 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 GVRGSLLSEADVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVRGSLLSEADVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 GPPYGPPSTWSVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPPYGPPSTWSVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILR 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 PRFRREVEKTACPSGKKAPEIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLD :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_016 PRFRREVEKTACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLD 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 VLKHKLDELYPQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLKHKLDELYPQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQ 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE4 VATLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VATLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDP 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE4 RQLDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQLDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDA 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE4 VLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLD 540 550 560 570 580 590 600 610 620 pF1KE4 LSMQEALSGTPCLLGPGPVLTVLALLLASTLA :::::::::::::::::::::::::::::::: XP_016 LSMQEALSGTPCLLGPGPVLTVLALLLASTLA 600 610 620 630 >>XP_016878346 (OMIM: 601051) PREDICTED: mesothelin isof (630 aa) initn: 2757 init1: 2757 opt: 4119 Z-score: 4237.7 bits: 794.3 E(85289): 0 Smith-Waterman score: 4119; 98.6% identity (98.6% similar) in 630 aa overlap (1-622:1-630) 10 20 30 40 50 60 pF1KE4 MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDGVLANPPNISS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDGVLANPPNISS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 DVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTW 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 SVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 ACPSGKKAPEIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELY :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELY 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 PQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQ--------VA :::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_016 PQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQAPRRPLPQVA 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE4 TLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQ 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE4 LDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVL 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE4 PLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLS 550 560 570 580 590 600 600 610 620 pF1KE4 MQEALSGTPCLLGPGPVLTVLALLLASTLA :::::::::::::::::::::::::::::: XP_016 MQEALSGTPCLLGPGPVLTVLALLLASTLA 610 620 630 >>XP_011520650 (OMIM: 601051) PREDICTED: mesothelin isof (630 aa) initn: 2757 init1: 2757 opt: 4119 Z-score: 4237.7 bits: 794.3 E(85289): 0 Smith-Waterman score: 4119; 98.6% identity (98.6% similar) in 630 aa overlap (1-622:1-630) 10 20 30 40 50 60 pF1KE4 MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDGVLANPPNISS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDGVLANPPNISS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 DVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTW 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 SVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 ACPSGKKAPEIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELY :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELY 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 PQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQ--------VA :::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_011 PQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQAPRRPLPQVA 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE4 TLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQ 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE4 LDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVL 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE4 PLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLS 550 560 570 580 590 600 600 610 620 pF1KE4 MQEALSGTPCLLGPGPVLTVLALLLASTLA :::::::::::::::::::::::::::::: XP_011 MQEALSGTPCLLGPGPVLTVLALLLASTLA 610 620 630 >>NP_037536 (OMIM: 601051) mesothelin isoform 2 prepropr (630 aa) initn: 2757 init1: 2757 opt: 4119 Z-score: 4237.7 bits: 794.3 E(85289): 0 Smith-Waterman score: 4119; 98.6% identity (98.6% similar) in 630 aa overlap (1-622:1-630) 10 20 30 40 50 60 pF1KE4 MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDGVLANPPNISS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDGVLANPPNISS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 LSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 DLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 DVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 DVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTW 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 SVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 SVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 ACPSGKKAPEIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELY :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 ACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELY 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 PQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQ--------VA :::::::::::::::::::::::::::::::::::::::::::::::::: :: NP_037 PQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQAPRRPLPQVA 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE4 TLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 TLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQ 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE4 LDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 LDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVL 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE4 PLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 PLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLS 550 560 570 580 590 600 600 610 620 pF1KE4 MQEALSGTPCLLGPGPVLTVLALLLASTLA :::::::::::::::::::::::::::::: NP_037 MQEALSGTPCLLGPGPVLTVLALLLASTLA 610 620 630 >>XP_016878342 (OMIM: 601051) PREDICTED: mesothelin isof (640 aa) initn: 2757 init1: 2757 opt: 4119 Z-score: 4237.6 bits: 794.3 E(85289): 0 Smith-Waterman score: 4119; 98.6% identity (98.6% similar) in 630 aa overlap (1-622:11-640) 10 20 30 40 50 pF1KE4 MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDG :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVASLKGTQTMALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 VLANPPNISSLSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLANPPNISSLSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 PPEDLDALPLDLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPEDLDALPLDLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACW 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 GVRGSLLSEADVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVRGSLLSEADVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGG 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 GPPYGPPSTWSVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPPYGPPSTWSVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILR 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE4 PRFRREVEKTACPSGKKAPEIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLD :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_016 PRFRREVEKTACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLD 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE4 VLKHKLDELYPQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLKHKLDELYPQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQ 370 380 390 400 410 420 420 430 440 450 460 pF1KE4 --------VATLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRP :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APRRPLPQVATLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRP 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE4 QDLDTCDPRQLDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QDLDTCDPRQLDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLAT 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE4 FMKLRTDAVLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FMKLRTDAVLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGI 550 560 570 580 590 600 590 600 610 620 pF1KE4 PNGYLVLDLSMQEALSGTPCLLGPGPVLTVLALLLASTLA :::::::::::::::::::::::::::::::::::::::: XP_016 PNGYLVLDLSMQEALSGTPCLLGPGPVLTVLALLLASTLA 610 620 630 640 >>XP_016878347 (OMIM: 601051) PREDICTED: mesothelin isof (629 aa) initn: 2465 init1: 2465 opt: 4101 Z-score: 4219.2 bits: 790.9 E(85289): 0 Smith-Waterman score: 4101; 98.4% identity (98.4% similar) in 630 aa overlap (1-622:1-629) 10 20 30 40 50 60 pF1KE4 MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDGVLANPPNISS ::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::: XP_016 MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQ-AAPLDGVLANPPNISS 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 LSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 DLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEA 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 DVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTW 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 SVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKT 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 ACPSGKKAPEIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELY :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELY 300 310 320 330 340 350 370 380 390 400 410 pF1KE4 PQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQ--------VA :::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_016 PQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQAPRRPLPQVA 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE4 TLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQ 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE4 LDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVL 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE4 PLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLS 540 550 560 570 580 590 600 610 620 pF1KE4 MQEALSGTPCLLGPGPVLTVLALLLASTLA :::::::::::::::::::::::::::::: XP_016 MQEALSGTPCLLGPGPVLTVLALLLASTLA 600 610 620 622 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 17:38:42 2016 done: Mon Nov 7 17:38:43 2016 Total Scan time: 12.640 Total Display time: 0.140 Function used was FASTA [36.3.4 Apr, 2011]