FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5139, 115 aa 1>>>pF1KE5139 115 - 115 aa - 115 aa Library: /omim/omim.rfq.tfa 64369986 residues in 92320 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0816+/-0.000301; mu= 11.5501+/- 0.019 mean_var=80.3823+/-15.592, 0's: 0 Z-trim(118.7): 141 B-trim: 451 in 2/49 Lambda= 0.143052 statistics sampled from 33090 (33284) to 33090 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.746), E-opt: 0.2 (0.361), width: 16 Scan time: 2.410 The best scores are: opt bits E(92320) XP_016877437 (OMIM: 610894) pro-neuregulin-4, memb ( 115) 801 173.9 5.3e-44 XP_024305616 (OMIM: 610894) pro-neuregulin-4, memb ( 115) 801 173.9 5.3e-44 XP_016877435 (OMIM: 610894) pro-neuregulin-4, memb ( 115) 801 173.9 5.3e-44 XP_016877436 (OMIM: 610894) pro-neuregulin-4, memb ( 115) 801 173.9 5.3e-44 NP_612640 (OMIM: 610894) pro-neuregulin-4, membran ( 115) 801 173.9 5.3e-44 XP_016877434 (OMIM: 610894) pro-neuregulin-4, memb ( 115) 801 173.9 5.3e-44 XP_016877427 (OMIM: 610894) pro-neuregulin-4, memb ( 129) 768 167.2 6.5e-42 XP_016877429 (OMIM: 610894) pro-neuregulin-4, memb ( 129) 768 167.2 6.5e-42 XP_016877428 (OMIM: 610894) pro-neuregulin-4, memb ( 129) 768 167.2 6.5e-42 XP_016877432 (OMIM: 610894) pro-neuregulin-4, memb ( 129) 768 167.2 6.5e-42 XP_016877430 (OMIM: 610894) pro-neuregulin-4, memb ( 129) 768 167.2 6.5e-42 XP_016877431 (OMIM: 610894) pro-neuregulin-4, memb ( 129) 768 167.2 6.5e-42 XP_024305615 (OMIM: 610894) pro-neuregulin-4, memb ( 129) 768 167.2 6.5e-42 XP_016877426 (OMIM: 610894) pro-neuregulin-4, memb ( 129) 768 167.2 6.5e-42 XP_016877433 (OMIM: 610894) pro-neuregulin-4, memb ( 123) 763 166.1 1.3e-41 NP_001423 (OMIM: 602061) proepiregulin preproprote ( 169) 166 43.0 0.0002 NP_001153468 (OMIM: 142445,603013) pro-neuregulin- ( 308) 162 42.5 0.00054 NP_001159444 (OMIM: 605533) pro-neuregulin-3, memb ( 695) 166 43.6 0.00055 NP_001357010 (OMIM: 605533) pro-neuregulin-3, memb ( 696) 166 43.6 0.00055 XP_016871073 (OMIM: 605533) pro-neuregulin-3, memb ( 393) 163 42.8 0.00056 XP_011537475 (OMIM: 605533) pro-neuregulin-3, memb ( 720) 166 43.6 0.00057 XP_016871069 (OMIM: 605533) pro-neuregulin-3, memb ( 721) 166 43.6 0.00057 XP_016871068 (OMIM: 605533) pro-neuregulin-3, memb ( 722) 166 43.6 0.00057 XP_016871065 (OMIM: 605533) pro-neuregulin-3, memb ( 745) 166 43.6 0.00058 XP_016871064 (OMIM: 605533) pro-neuregulin-3, memb ( 746) 166 43.6 0.00058 XP_016871072 (OMIM: 605533) pro-neuregulin-3, memb ( 436) 163 42.8 0.0006 XP_016871071 (OMIM: 605533) pro-neuregulin-3, memb ( 461) 163 42.8 0.00063 NP_001159445 (OMIM: 605533) pro-neuregulin-3, memb ( 499) 163 42.9 0.00067 NP_001357011 (OMIM: 605533) pro-neuregulin-3, memb ( 507) 163 42.9 0.00067 NP_039254 (OMIM: 142445,603013) pro-neuregulin-1, ( 462) 162 42.6 0.00073 NP_053584 (OMIM: 603818) pro-neuregulin-2, membran ( 844) 165 43.5 0.00073 XP_016868860 (OMIM: 142445,603013) pro-neuregulin- ( 469) 162 42.6 0.00074 XP_016868859 (OMIM: 142445,603013) pro-neuregulin- ( 486) 162 42.6 0.00075 NP_001010848 (OMIM: 605533) pro-neuregulin-3, memb ( 696) 163 43.0 0.00085 XP_011537477 (OMIM: 605533) pro-neuregulin-3, memb ( 697) 163 43.0 0.00085 NP_001357013 (OMIM: 605533) pro-neuregulin-3, memb ( 720) 163 43.0 0.00087 XP_011537474 (OMIM: 605533) pro-neuregulin-3, memb ( 721) 163 43.0 0.00087 XP_016871067 (OMIM: 605533) pro-neuregulin-3, memb ( 722) 163 43.0 0.00087 XP_016871066 (OMIM: 605533) pro-neuregulin-3, memb ( 723) 163 43.0 0.00087 XP_024302911 (OMIM: 142445,603013) pro-neuregulin- ( 606) 162 42.7 0.00089 XP_016871063 (OMIM: 605533) pro-neuregulin-3, memb ( 746) 163 43.0 0.00089 XP_016871062 (OMIM: 605533) pro-neuregulin-3, memb ( 747) 163 43.0 0.00089 NP_039258 (OMIM: 142445,603013) pro-neuregulin-1, ( 640) 162 42.7 0.00092 XP_016868854 (OMIM: 142445,603013) pro-neuregulin- ( 647) 162 42.7 0.00093 XP_005273543 (OMIM: 142445,603013) pro-neuregulin- ( 695) 162 42.8 0.00098 NP_001153480 (OMIM: 142445,603013) pro-neuregulin- ( 420) 158 41.8 0.0012 NP_001153476 (OMIM: 142445,603013) pro-neuregulin- ( 459) 158 41.8 0.0013 XP_016868861 (OMIM: 142445,603013) pro-neuregulin- ( 466) 158 41.8 0.0013 NP_001309126 (OMIM: 142445,603013) pro-neuregulin- ( 483) 158 41.8 0.0013 NP_053586 (OMIM: 603818) pro-neuregulin-2, membran ( 852) 160 42.4 0.0015 >>XP_016877437 (OMIM: 610894) pro-neuregulin-4, membrane (115 aa) initn: 801 init1: 801 opt: 801 Z-score: 911.6 bits: 173.9 E(92320): 5.3e-44 Smith-Waterman score: 801; 100.0% identity (100.0% similar) in 115 aa overlap (1-115:1-115) 10 20 30 40 50 60 pF1KE5 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH 70 80 90 100 110 >>XP_024305616 (OMIM: 610894) pro-neuregulin-4, membrane (115 aa) initn: 801 init1: 801 opt: 801 Z-score: 911.6 bits: 173.9 E(92320): 5.3e-44 Smith-Waterman score: 801; 100.0% identity (100.0% similar) in 115 aa overlap (1-115:1-115) 10 20 30 40 50 60 pF1KE5 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH 70 80 90 100 110 >>XP_016877435 (OMIM: 610894) pro-neuregulin-4, membrane (115 aa) initn: 801 init1: 801 opt: 801 Z-score: 911.6 bits: 173.9 E(92320): 5.3e-44 Smith-Waterman score: 801; 100.0% identity (100.0% similar) in 115 aa overlap (1-115:1-115) 10 20 30 40 50 60 pF1KE5 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH 70 80 90 100 110 >>XP_016877436 (OMIM: 610894) pro-neuregulin-4, membrane (115 aa) initn: 801 init1: 801 opt: 801 Z-score: 911.6 bits: 173.9 E(92320): 5.3e-44 Smith-Waterman score: 801; 100.0% identity (100.0% similar) in 115 aa overlap (1-115:1-115) 10 20 30 40 50 60 pF1KE5 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH 70 80 90 100 110 >>NP_612640 (OMIM: 610894) pro-neuregulin-4, membrane-bo (115 aa) initn: 801 init1: 801 opt: 801 Z-score: 911.6 bits: 173.9 E(92320): 5.3e-44 Smith-Waterman score: 801; 100.0% identity (100.0% similar) in 115 aa overlap (1-115:1-115) 10 20 30 40 50 60 pF1KE5 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH 70 80 90 100 110 >>XP_016877434 (OMIM: 610894) pro-neuregulin-4, membrane (115 aa) initn: 801 init1: 801 opt: 801 Z-score: 911.6 bits: 173.9 E(92320): 5.3e-44 Smith-Waterman score: 801; 100.0% identity (100.0% similar) in 115 aa overlap (1-115:1-115) 10 20 30 40 50 60 pF1KE5 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH 70 80 90 100 110 >>XP_016877427 (OMIM: 610894) pro-neuregulin-4, membrane (129 aa) initn: 768 init1: 768 opt: 768 Z-score: 874.1 bits: 167.2 E(92320): 6.5e-42 Smith-Waterman score: 768; 100.0% identity (100.0% similar) in 111 aa overlap (1-111:1-111) 10 20 30 40 50 60 pF1KE5 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSIHWGLGMYP 70 80 90 100 110 120 XP_016 PWRRGDYCT >>XP_016877429 (OMIM: 610894) pro-neuregulin-4, membrane (129 aa) initn: 768 init1: 768 opt: 768 Z-score: 874.1 bits: 167.2 E(92320): 6.5e-42 Smith-Waterman score: 768; 100.0% identity (100.0% similar) in 111 aa overlap (1-111:1-111) 10 20 30 40 50 60 pF1KE5 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSIHWGLGMYP 70 80 90 100 110 120 XP_016 PWRRGDYCT >>XP_016877428 (OMIM: 610894) pro-neuregulin-4, membrane (129 aa) initn: 768 init1: 768 opt: 768 Z-score: 874.1 bits: 167.2 E(92320): 6.5e-42 Smith-Waterman score: 768; 100.0% identity (100.0% similar) in 111 aa overlap (1-111:1-111) 10 20 30 40 50 60 pF1KE5 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSIHWGLGMYP 70 80 90 100 110 120 XP_016 PWRRGDYCT >>XP_016877432 (OMIM: 610894) pro-neuregulin-4, membrane (129 aa) initn: 768 init1: 768 opt: 768 Z-score: 874.1 bits: 167.2 E(92320): 6.5e-42 Smith-Waterman score: 768; 100.0% identity (100.0% similar) in 111 aa overlap (1-111:1-111) 10 20 30 40 50 60 pF1KE5 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSIHWGLGMYP 70 80 90 100 110 120 XP_016 PWRRGDYCT 115 residues in 1 query sequences 64369986 residues in 92320 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Oct 24 21:45:30 2019 done: Thu Oct 24 21:45:30 2019 Total Scan time: 2.410 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]