Result of FASTA (omim) for
pF1KE5553
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5553, 426 aa
1>>>pF1KE5553 426 - 426 aa - 426 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.6008+/-0.000448; mu= 21.6585+/- 0.028
mean_var=62.6412+/-13.160, 0's: 0 Z-trim(109.2): 43 B-trim: 493 in 1/49
Lambda= 0.162048
statistics sampled from 17319 (17347) to 17319 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.555), E-opt: 0.2 (0.203), width: 16
Scan time: 8.490
The best scores are: opt bits E(85289)
NP_056183 (OMIM: 608420) pannexin-1 [Homo sapiens] ( 426) 2775 657.8 1.5e-188
XP_016872953 (OMIM: 608420) PREDICTED: pannexin-1 ( 284) 1822 434.8 1.3e-121
XP_011541036 (OMIM: 608420) PREDICTED: pannexin-1 ( 284) 1822 434.8 1.3e-121
NP_443191 (OMIM: 608422) pannexin-3 [Homo sapiens] ( 392) 929 226.2 1.2e-58
NP_001153772 (OMIM: 608421) pannexin-2 isoform 2 [ ( 643) 456 115.8 3.3e-25
NP_443071 (OMIM: 608421) pannexin-2 isoform 1 [Hom ( 677) 456 115.8 3.4e-25
>>NP_056183 (OMIM: 608420) pannexin-1 [Homo sapiens] (426 aa)
initn: 2775 init1: 2775 opt: 2775 Z-score: 3506.0 bits: 657.8 E(85289): 1.5e-188
Smith-Waterman score: 2775; 100.0% identity (100.0% similar) in 426 aa overlap (1-426:1-426)
10 20 30 40 50 60
pF1KE5 MAIAQLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MAIAQLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 GTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNLPLWLHKFFPYILLLFAILL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNLPLWLHKFFPYILLLFAILL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 YLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAIKAAKSARDLDMRDGACSVPGVTENLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 YLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAIKAAKSARDLDMRDGACSVPGVTENLG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 QSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLGYYFSLSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLGYYFSLSSL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 SDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVVYTLFVPFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVVYTLFVPFR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 QKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISEVKSYKCLKVLENIKSSGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISEVKSYKCLKVLENIKSSGQG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 IDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKANNGEKNARQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 IDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKANNGEKNARQR
370 380 390 400 410 420
pF1KE5 LLDSSC
::::::
NP_056 LLDSSC
>>XP_016872953 (OMIM: 608420) PREDICTED: pannexin-1 isof (284 aa)
initn: 1822 init1: 1822 opt: 1822 Z-score: 2304.3 bits: 434.8 E(85289): 1.3e-121
Smith-Waterman score: 1822; 100.0% identity (100.0% similar) in 284 aa overlap (143-426:1-284)
120 130 140 150 160 170
pF1KE5 LLLFAILLYLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAIKAAKSARDLDMRDGACSV
::::::::::::::::::::::::::::::
XP_016 MEELDKVYNRAIKAAKSARDLDMRDGACSV
10 20 30
180 190 200 210 220 230
pF1KE5 PGVTENLGQSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGVTENLGQSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLG
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE5 YYFSLSSLSDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YYFSLSSLSDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVV
100 110 120 130 140 150
300 310 320 330 340 350
pF1KE5 YTLFVPFRQKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISEVKSYKCLKVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YTLFVPFRQKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISEVKSYKCLKVLE
160 170 180 190 200 210
360 370 380 390 400 410
pF1KE5 NIKSSGQGIDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKANN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NIKSSGQGIDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKANN
220 230 240 250 260 270
420
pF1KE5 GEKNARQRLLDSSC
::::::::::::::
XP_016 GEKNARQRLLDSSC
280
>>XP_011541036 (OMIM: 608420) PREDICTED: pannexin-1 isof (284 aa)
initn: 1822 init1: 1822 opt: 1822 Z-score: 2304.3 bits: 434.8 E(85289): 1.3e-121
Smith-Waterman score: 1822; 100.0% identity (100.0% similar) in 284 aa overlap (143-426:1-284)
120 130 140 150 160 170
pF1KE5 LLLFAILLYLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAIKAAKSARDLDMRDGACSV
::::::::::::::::::::::::::::::
XP_011 MEELDKVYNRAIKAAKSARDLDMRDGACSV
10 20 30
180 190 200 210 220 230
pF1KE5 PGVTENLGQSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGVTENLGQSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLG
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE5 YYFSLSSLSDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YYFSLSSLSDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVV
100 110 120 130 140 150
300 310 320 330 340 350
pF1KE5 YTLFVPFRQKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISEVKSYKCLKVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YTLFVPFRQKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISEVKSYKCLKVLE
160 170 180 190 200 210
360 370 380 390 400 410
pF1KE5 NIKSSGQGIDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKANN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIKSSGQGIDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKANN
220 230 240 250 260 270
420
pF1KE5 GEKNARQRLLDSSC
::::::::::::::
XP_011 GEKNARQRLLDSSC
280
>>NP_443191 (OMIM: 608422) pannexin-3 [Homo sapiens] (392 aa)
initn: 927 init1: 353 opt: 929 Z-score: 1174.1 bits: 226.2 E(85289): 1.2e-58
Smith-Waterman score: 929; 43.3% identity (72.5% similar) in 360 aa overlap (1-357:1-355)
10 20 30 40 50 60
pF1KE5 MAIAQLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISI
:..:. :.::..:: :: . :..::::::: .:..: .::: ::::.:::::::.:
NP_443 MSLAHTAAEYMLSDALLPDRRGPRLKGLRLELPLDRIVKFVAVGSPLLLMSLAFAQEFSS
10 20 30 40 50 60
70 80 90 100 110
pF1KE5 GTQISCFSPSSFSWRQAAFVDSYCWAAV-QQKNSLQSESGNLPLWLHKFFPYILLLFAIL
:. :::::::.:: ::::.::: :: .. ..:.. ... :: :: .:: :: .:.:
NP_443 GSPISCFSPSNFSIRQAAYVDSSCWDSLLHHKQDGPGQDKMKSLWPHKALPYSLLALALL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 LYLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAIKAAKSARDLDMRDGACSVPGVTENL
.::: :.:..::.: . ::: ::. :::: :::.:. .. : .:. . : : : :
NP_443 MYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQHM--LKIRQKS-SDPYVFWNE
130 140 150 160 170
180 190 200 210 220 230
pF1KE5 GQSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLGYYFSLSS
.. . : .:..:..:.:: :. :..:. :. : ::. . .:::..
NP_443 LEKARK--ERYFEFPLLERYLACKQRSHSLVATYLLRNSLLLIFTSATYLYLGHFHLDVF
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE5 LSDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVVYTLFVPF
...:: ::::.:.: ... ::. . :.: ...:::..:. ....:..:.::..:.:
NP_443 FQEEFSCSIKTGLLSDETHVPNLITCRLTSLSIFQIVSLSSVAIYTILVPVIIYNLTRLC
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE5 RQKTDVLKVYEILPTFDVLHFKSEG--YNDLSLYNLFLEENISEVKSYKCLKVLENIKSS
: .:.:::.::.::.: : : :::.. :::. ::::. :.. :.:: .:..
NP_443 RWDKRLLSVYEMLPAFDLLSRKMLGCPINDLNVILLFLRANISELISFSWLSVLCVLKDT
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE5 GQGIDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKANNGEKNA
NP_443 TTQKHNIDTVVDFMTLLAGLEPSKPKHLTNSACDEHP
360 370 380 390
>>NP_001153772 (OMIM: 608421) pannexin-2 isoform 2 [Homo (643 aa)
initn: 314 init1: 206 opt: 456 Z-score: 573.6 bits: 115.8 E(85289): 3.3e-25
Smith-Waterman score: 456; 27.3% identity (63.8% similar) in 337 aa overlap (28-353:44-369)
10 20 30 40 50
pF1KE5 MAIAQLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQE
:.::: :..:: .: .:.::..:.:...
NP_001 ALLAGEKLRELILPGAQDDKAGALAALLLQLKLELPFDRVVTIGTVLVPILLVTLVFTKN
20 30 40 50 60 70
60 70 80 90 100 110
pF1KE5 ISIGTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNL-P-LWLHKFFPYILLL
.. : :..: .:. :: .. .::: .. ...: . ...: : :. :::.:: ::
NP_001 FA-EEPIYCYTPHNFTRDQALYARGYCW--TELRDALPGVDASLWPSLFEHKFLPYALLA
80 90 100 110 120 130
120 130 140 150 160 170
pF1KE5 FAILLYLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAI--KAAKSARDLDMRDGACSVP
:: ..:.: : :.: :. .. :.:.:...:.:. :.:: .: : .... . :
NP_001 FAAIMYVPALGWEFLASTRLTSELNFLLQEIDNCYHRAAEGRAPKIEKQIQSKG-----P
140 150 160 170 180
180 190 200 210 220 230
pF1KE5 GVTENLGQSLWEVSESHFKYP---IVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIY
:.:: . . : .:.. : : . :.::. . :: : :.. ..: :.. . :
NP_001 GITEREKREIIENAEKE-KSPEQNLFEKYLERRGRSNFLAKLYLARHVLILLLSAVPISY
190 200 210 220 230 240
240 250 260 270 280
pF1KE5 LGYYFSLSSLSDEFVCSIKSGILRNDSTVPD-QFQCKLIAVGIFQLLSVINLVVYVLLAP
: :.. .. ..::.:.. .. .. : . .::: .: . .... ...:. ..
NP_001 LCTYYA-TQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSVQLQRIIAGVDIVLLCVMNL
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE5 VVVYTL---FVPFRQKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISEVKSYK
... .: :. ::... .. . . ... . :... .: .:: ...:: .
NP_001 IILVNLIHLFI-FRKSNFIFDKLHKVGIKTRRQWRRSQFCDINILAMFCNENRDHIKSLN
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE5 CLKVLENIKSSGQGIDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDS
: . :
NP_001 RLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQTVDPSANPAEPDGAAEPPV
370 380 390 400 410 420
>>NP_443071 (OMIM: 608421) pannexin-2 isoform 1 [Homo sa (677 aa)
initn: 252 init1: 206 opt: 456 Z-score: 573.3 bits: 115.8 E(85289): 3.4e-25
Smith-Waterman score: 456; 27.3% identity (63.8% similar) in 337 aa overlap (28-353:44-369)
10 20 30 40 50
pF1KE5 MAIAQLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQE
:.::: :..:: .: .:.::..:.:...
NP_443 ALLAGEKLRELILPGAQDDKAGALAALLLQLKLELPFDRVVTIGTVLVPILLVTLVFTKN
20 30 40 50 60 70
60 70 80 90 100 110
pF1KE5 ISIGTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNL-P-LWLHKFFPYILLL
.. : :..: .:. :: .. .::: .. ...: . ...: : :. :::.:: ::
NP_443 FA-EEPIYCYTPHNFTRDQALYARGYCW--TELRDALPGVDASLWPSLFEHKFLPYALLA
80 90 100 110 120 130
120 130 140 150 160 170
pF1KE5 FAILLYLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAI--KAAKSARDLDMRDGACSVP
:: ..:.: : :.: :. .. :.:.:...:.:. :.:: .: : .... . :
NP_443 FAAIMYVPALGWEFLASTRLTSELNFLLQEIDNCYHRAAEGRAPKIEKQIQSKG-----P
140 150 160 170 180
180 190 200 210 220 230
pF1KE5 GVTENLGQSLWEVSESHFKYP---IVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIY
:.:: . . : .:.. : : . :.::. . :: : :.. ..: :.. . :
NP_443 GITEREKREIIENAEKE-KSPEQNLFEKYLERRGRSNFLAKLYLARHVLILLLSAVPISY
190 200 210 220 230 240
240 250 260 270 280
pF1KE5 LGYYFSLSSLSDEFVCSIKSGILRNDSTVPD-QFQCKLIAVGIFQLLSVINLVVYVLLAP
: :.. .. ..::.:.. .. .. : . .::: .: . .... ...:. ..
NP_443 LCTYYA-TQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSVQLQRIIAGVDIVLLCVMNL
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE5 VVVYTL---FVPFRQKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISEVKSYK
... .: :. ::... .. . . ... . :... .: .:: ...:: .
NP_443 IILVNLIHLFI-FRKSNFIFDKLHKVGIKTRRQWRRSQFCDINILAMFCNENRDHIKSLN
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE5 CLKVLENIKSSGQGIDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDS
: . :
NP_443 RLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQTVDPSANPAEPDGAAEPPV
370 380 390 400 410 420
426 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 01:45:53 2016 done: Tue Nov 8 01:45:54 2016
Total Scan time: 8.490 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]