FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6673, 309 aa 1>>>pF1KE6673 309 - 309 aa - 309 aa Library: /omim/omim.rfq.tfa 64092750 residues in 91774 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3672+/-0.00031; mu= 16.7994+/- 0.019 mean_var=84.6775+/-16.968, 0's: 0 Z-trim(116.7): 92 B-trim: 0 in 0/51 Lambda= 0.139377 statistics sampled from 29045 (29140) to 29045 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.696), E-opt: 0.2 (0.318), width: 16 Scan time: 3.420 The best scores are: opt bits E(91774) NP_004359 (OMIM: 602373) calponin-2 isoform a [Hom ( 309) 2108 433.3 3.1e-121 NP_001830 (OMIM: 602374) calponin-3 isoform 1 [Hom ( 329) 1324 275.7 9.4e-74 NP_001290428 (OMIM: 602373) calponin-2 isoform c [ ( 298) 1258 262.4 8.6e-70 NP_001290430 (OMIM: 602373) calponin-2 isoform d [ ( 330) 1254 261.6 1.6e-69 NP_001290 (OMIM: 600806) calponin-1 isoform 1 [Hom ( 297) 1217 254.2 2.6e-67 XP_016855734 (OMIM: 602374) calponin-3 isoform X1 ( 288) 1129 236.5 5.4e-62 NP_001272985 (OMIM: 602374) calponin-3 isoform 3 [ ( 288) 1129 236.5 5.4e-62 XP_024307130 (OMIM: 600806) calponin-1 isoform X2 ( 299) 1104 231.4 1.8e-60 XP_024307129 (OMIM: 600806) calponin-1 isoform X2 ( 299) 1104 231.4 1.8e-60 XP_016881778 (OMIM: 600806) calponin-1 isoform X1 ( 363) 1104 231.5 2.1e-60 NP_958434 (OMIM: 602373) calponin-2 isoform b [Hom ( 270) 1010 212.5 8.2e-55 NP_001295270 (OMIM: 600806) calponin-1 isoform 2 [ ( 247) 985 207.4 2.5e-53 NP_001295271 (OMIM: 600806) calponin-1 isoform 2 [ ( 247) 985 207.4 2.5e-53 XP_005259798 (OMIM: 600806) calponin-1 isoform X3 ( 247) 985 207.4 2.5e-53 NP_001272984 (OMIM: 602374) calponin-3 isoform 2 [ ( 283) 736 157.4 3.3e-38 NP_001264152 (OMIM: 604634) transgelin-2 isoform b ( 199) 390 87.7 2.2e-17 NP_003555 (OMIM: 604634) transgelin-2 isoform b [H ( 199) 390 87.7 2.2e-17 NP_001264153 (OMIM: 604634) transgelin-2 isoform a ( 220) 390 87.8 2.4e-17 NP_037391 (OMIM: 607953) transgelin-3 [Homo sapien ( 199) 373 84.3 2.4e-16 NP_001008274 (OMIM: 607953) transgelin-3 [Homo sap ( 199) 373 84.3 2.4e-16 NP_001008273 (OMIM: 607953) transgelin-3 [Homo sap ( 199) 373 84.3 2.4e-16 NP_001001522 (OMIM: 600818) transgelin [Homo sapie ( 201) 323 74.3 2.5e-13 NP_003177 (OMIM: 600818) transgelin [Homo sapiens] ( 201) 323 74.3 2.5e-13 NP_001317713 (OMIM: 617750) LIM and calponin homol ( 980) 212 52.5 4.3e-06 NP_001317718 (OMIM: 617750) LIM and calponin homol (1029) 212 52.5 4.5e-06 NP_001317721 (OMIM: 617750) LIM and calponin homol (1044) 212 52.5 4.5e-06 NP_001317717 (OMIM: 617750) LIM and calponin homol (1055) 212 52.5 4.6e-06 NP_001106189 (OMIM: 617750) LIM and calponin homol (1056) 212 52.5 4.6e-06 NP_001106188 (OMIM: 617750) LIM and calponin homol (1057) 212 52.5 4.6e-06 XP_016863389 (OMIM: 617750) LIM and calponin homol (1058) 212 52.5 4.6e-06 NP_001276051 (OMIM: 617750) LIM and calponin homol (1069) 212 52.5 4.6e-06 NP_001317720 (OMIM: 617750) LIM and calponin homol (1070) 212 52.5 4.6e-06 XP_024309705 (OMIM: 617750) LIM and calponin homol (1074) 212 52.5 4.6e-06 NP_001317719 (OMIM: 617750) LIM and calponin homol (1082) 212 52.5 4.7e-06 NP_055803 (OMIM: 617750) LIM and calponin homology (1083) 212 52.5 4.7e-06 NP_001317716 (OMIM: 617750) LIM and calponin homol (1085) 212 52.6 4.7e-06 XP_016863387 (OMIM: 617750) LIM and calponin homol (1086) 212 52.6 4.7e-06 XP_011511956 (OMIM: 617750) LIM and calponin homol (1099) 212 52.6 4.7e-06 XP_011511955 (OMIM: 617750) LIM and calponin homol (1111) 212 52.6 4.7e-06 XP_016863386 (OMIM: 617750) LIM and calponin homol (1573) 212 52.7 6.2e-06 XP_011511950 (OMIM: 617750) LIM and calponin homol (1574) 212 52.7 6.2e-06 XP_016863385 (OMIM: 617750) LIM and calponin homol (1598) 212 52.7 6.2e-06 XP_006714059 (OMIM: 617750) LIM and calponin homol (1600) 212 52.7 6.2e-06 XP_005248118 (OMIM: 617750) LIM and calponin homol (1602) 212 52.7 6.2e-06 XP_011511948 (OMIM: 617750) LIM and calponin homol (1626) 212 52.7 6.3e-06 XP_005248117 (OMIM: 617750) LIM and calponin homol (1626) 212 52.7 6.3e-06 XP_011511947 (OMIM: 617750) LIM and calponin homol (1627) 212 52.7 6.3e-06 XP_016863384 (OMIM: 617750) LIM and calponin homol (1627) 212 52.7 6.3e-06 XP_005248115 (OMIM: 617750) LIM and calponin homol (1629) 212 52.7 6.3e-06 XP_005248114 (OMIM: 617750) LIM and calponin homol (1630) 212 52.7 6.3e-06 >>NP_004359 (OMIM: 602373) calponin-2 isoform a [Homo sa (309 aa) initn: 2108 init1: 2108 opt: 2108 Z-score: 2298.0 bits: 433.3 E(91774): 3.1e-121 Smith-Waterman score: 2108; 100.0% identity (100.0% similar) in 309 aa overlap (1-309:1-309) 10 20 30 40 50 60 pF1KE6 MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTIL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 CTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 CTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 QVSLLALAGKAKTKGLQSGVDIGVKYSEKQERNFDDATMKAGQCVIGLQMGTNKCASQSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QVSLLALAGKAKTKGLQSGVDIGVKYSEKQERNFDDATMKAGQCVIGLQMGTNKCASQSG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 MTAYGTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MTAYGTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 DNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQGTVADGAPSGTGDCPDPGEVPEYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQGTVADGAPSGTGDCPDPGEVPEYP 250 260 270 280 290 300 pF1KE6 PYYQEEAGY ::::::::: NP_004 PYYQEEAGY >>NP_001830 (OMIM: 602374) calponin-3 isoform 1 [Homo sa (329 aa) initn: 1503 init1: 1201 opt: 1324 Z-score: 1445.7 bits: 275.7 E(91774): 9.4e-74 Smith-Waterman score: 1324; 65.5% identity (81.6% similar) in 310 aa overlap (4-306:2-311) 10 20 30 40 50 60 pF1KE6 MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTIL :.:::::::::::::::.. :::: : : .::.::: .::.::::.:: ::::: :: NP_001 MTHFNKGPSYGLSAEVKNKIASKYDHQAEEDLRNWIEEVTGMSIGPNFQLGLKDGIIL 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 CTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQV : :.:::::::: :.:.: :: ::::..:::::. .:::.: :.::::::::.:::::: NP_001 CELINKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 QVSLLALAGKAKTKGLQSGVDIGVKYSEKQERNFDDATMKAGQCVIGLQMGTNKCASQSG :..:.:::: :::::... .::::::.::: : ::.. .:::: ::::::::::::::.: NP_001 QTTLVALAGLAKTKGFHTTIDIGVKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAG 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE6 MTAYGTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKC :::::::::::::: . :.:..:::::::::: :::.:: :::::: ::: :: . NP_001 MTAYGTRRHLYDPKMQTDKPFDQTTISLQMGTNKGASQAGMLAPGTRRDIYDQKLTLQPV 180 190 200 210 220 230 250 260 270 280 290 pF1KE6 DNSSMSLQMGYTQGANQSGQ-VFGLGRQIYDPKYC--PQGTVADGAPSGTG----DCPDP :::..::::: .. :.:.:. :.:::::.:::::: : : .. .::: . : NP_001 DNSTISLQMGTNKVASQKGMSVYGLGRQVYDPKYCAAPTEPVIHNGSQGTGTNGSEISDS 240 250 260 270 280 290 300 pF1KE6 GEVPEYPPYYQEEAGY ::: :. : NP_001 DYQAEYPDEYHGEYQDDYPRDYQYSDQGIDY 300 310 320 >>NP_001290428 (OMIM: 602373) calponin-2 isoform c [Homo (298 aa) initn: 1254 init1: 1254 opt: 1258 Z-score: 1374.5 bits: 262.4 E(91774): 8.6e-70 Smith-Waterman score: 2015; 96.4% identity (96.4% similar) in 309 aa overlap (1-309:1-298) 10 20 30 40 50 60 pF1KE6 MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTIL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 CTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQV ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQ- 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 QVSLLALAGKAKTKGLQSGVDIGVKYSEKQERNFDDATMKAGQCVIGLQMGTNKCASQSG :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ----------AKTKGLQSGVDIGVKYSEKQERNFDDATMKAGQCVIGLQMGTNKCASQSG 120 130 140 150 160 190 200 210 220 230 240 pF1KE6 MTAYGTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTAYGTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKC 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE6 DNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQGTVADGAPSGTGDCPDPGEVPEYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQGTVADGAPSGTGDCPDPGEVPEYP 230 240 250 260 270 280 pF1KE6 PYYQEEAGY ::::::::: NP_001 PYYQEEAGY 290 >>NP_001290430 (OMIM: 602373) calponin-2 isoform d [Homo (330 aa) initn: 1254 init1: 1254 opt: 1254 Z-score: 1369.6 bits: 261.6 E(91774): 1.6e-69 Smith-Waterman score: 2056; 93.6% identity (93.6% similar) in 330 aa overlap (1-309:1-330) 10 20 30 40 50 60 pF1KE6 MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTIL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 CTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQV 70 80 90 100 110 120 130 140 150 pF1KE6 QVSLLALAGK---------------------AKTKGLQSGVDIGVKYSEKQERNFDDATM :::::::::: ::::::::::::::::::::::::::::: NP_001 QVSLLALAGKGLDLGSLAALCWYSRPLSLTQAKTKGLQSGVDIGVKYSEKQERNFDDATM 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE6 KAGQCVIGLQMGTNKCASQSGMTAYGTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAGQCVIGLQMGTNKCASQSGMTAYGTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQV 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE6 GMTAPGTRRHIYDTKLGTDKCDNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQGTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GMTAPGTRRHIYDTKLGTDKCDNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQGTV 250 260 270 280 290 300 280 290 300 pF1KE6 ADGAPSGTGDCPDPGEVPEYPPYYQEEAGY :::::::::::::::::::::::::::::: NP_001 ADGAPSGTGDCPDPGEVPEYPPYYQEEAGY 310 320 330 >>NP_001290 (OMIM: 600806) calponin-1 isoform 1 [Homo sa (297 aa) initn: 1449 init1: 636 opt: 1217 Z-score: 1330.0 bits: 254.2 E(91774): 2.6e-67 Smith-Waterman score: 1217; 65.8% identity (85.8% similar) in 275 aa overlap (1-274:1-273) 10 20 30 40 50 60 pF1KE6 MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTIL :::..::.::.:::::::::.: .::: :.: ::: ::::.:: :: .:. ::::: :: NP_001 MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIIL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 CTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQV : ..:::::::: :::.: ::::::::..:::::...::..: :.::::::::. : ::: NP_001 CEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 QVSLLALAGKAKTKGLQSGVDIGVKYSEKQERNFDDATMKAGQCVIGLQMGTNKCASQSG : .:::::. ::::: . :..::::.:::::.:. . .. :. .::::::::: :::.: NP_001 QSTLLALASMAKTKG--NKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQG 130 140 150 160 170 190 200 210 220 230 240 pF1KE6 MTAYGTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKC :::::::::::::: :.:..:::::::::: :::.:::::::.:.:.. :: ..: NP_001 MTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHC 180 190 200 210 220 230 250 260 270 280 290 pF1KE6 DNSSMSLQMGYTQGANQSGQ-VFGLGRQIYDPKYCPQGTVADGAPSGTGDCPDPGEVPEY :. ..::::: ..::.: :. :.:: ::.:::::: NP_001 DTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHAHNYYNSA 240 250 260 270 280 290 300 pF1KE6 PPYYQEEAGY >>XP_016855734 (OMIM: 602374) calponin-3 isoform X1 [Hom (288 aa) initn: 1311 init1: 1009 opt: 1129 Z-score: 1234.6 bits: 236.5 E(91774): 5.4e-62 Smith-Waterman score: 1129; 64.4% identity (80.7% similar) in 270 aa overlap (44-306:1-270) 20 30 40 50 60 70 pF1KE6 LSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTILCTLMNKLQPGSVP .::::.:: ::::: ::: :.:::::::: XP_016 MSIGPNFQLGLKDGIILCELINKLQPGSVK 10 20 30 80 90 100 110 120 130 pF1KE6 KINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKAKT :.:.: :: ::::..:::::. .:::.: :.::::::::.:::::::..:.:::: ::: XP_016 KVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVALAGLAKT 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE6 KGLQSGVDIGVKYSEKQERNFDDATMKAGQCVIGLQMGTNKCASQSGMTAYGTRRHLYDP ::... .::::::.::: : ::.. .:::: ::::::::::::::.:::::::::::::: XP_016 KGFHTTIDIGVKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMTAYGTRRHLYDP 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE6 KNHILPPMDHSTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKCDNSSMSLQMGYTQ : . :.:..:::::::::: :::.:: :::::: ::: :: . :::..::::: .. XP_016 KMQTDKPFDQTTISLQMGTNKGASQAGMLAPGTRRDIYDQKLTLQPVDNSTISLQMGTNK 160 170 180 190 200 210 260 270 280 290 300 pF1KE6 GANQSGQ-VFGLGRQIYDPKYC--PQGTVADGAPSGTG----DCPDPGEVPEYPPYYQEE :.:.:. :.:::::.:::::: : : .. .::: . : ::: :. : XP_016 VASQKGMSVYGLGRQVYDPKYCAAPTEPVIHNGSQGTGTNGSEISDSDYQAEYPDEYHGE 220 230 240 250 260 270 pF1KE6 AGY XP_016 YQDDYPRDYQYSDQGIDY 280 >>NP_001272985 (OMIM: 602374) calponin-3 isoform 3 [Homo (288 aa) initn: 1311 init1: 1009 opt: 1129 Z-score: 1234.6 bits: 236.5 E(91774): 5.4e-62 Smith-Waterman score: 1129; 64.4% identity (80.7% similar) in 270 aa overlap (44-306:1-270) 20 30 40 50 60 70 pF1KE6 LSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTILCTLMNKLQPGSVP .::::.:: ::::: ::: :.:::::::: NP_001 MSIGPNFQLGLKDGIILCELINKLQPGSVK 10 20 30 80 90 100 110 120 130 pF1KE6 KINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKAKT :.:.: :: ::::..:::::. .:::.: :.::::::::.:::::::..:.:::: ::: NP_001 KVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVALAGLAKT 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE6 KGLQSGVDIGVKYSEKQERNFDDATMKAGQCVIGLQMGTNKCASQSGMTAYGTRRHLYDP ::... .::::::.::: : ::.. .:::: ::::::::::::::.:::::::::::::: NP_001 KGFHTTIDIGVKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMTAYGTRRHLYDP 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE6 KNHILPPMDHSTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKCDNSSMSLQMGYTQ : . :.:..:::::::::: :::.:: :::::: ::: :: . :::..::::: .. NP_001 KMQTDKPFDQTTISLQMGTNKGASQAGMLAPGTRRDIYDQKLTLQPVDNSTISLQMGTNK 160 170 180 190 200 210 260 270 280 290 300 pF1KE6 GANQSGQ-VFGLGRQIYDPKYC--PQGTVADGAPSGTG----DCPDPGEVPEYPPYYQEE :.:.:. :.:::::.:::::: : : .. .::: . : ::: :. : NP_001 VASQKGMSVYGLGRQVYDPKYCAAPTEPVIHNGSQGTGTNGSEISDSDYQAEYPDEYHGE 220 230 240 250 260 270 pF1KE6 AGY NP_001 YQDDYPRDYQYSDQGIDY 280 >>XP_024307130 (OMIM: 600806) calponin-1 isoform X2 [Hom (299 aa) initn: 1333 init1: 529 opt: 1104 Z-score: 1207.2 bits: 231.4 E(91774): 1.8e-60 Smith-Waterman score: 1104; 65.0% identity (84.6% similar) in 254 aa overlap (22-274:24-275) 10 20 30 40 50 pF1KE6 MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGT : .::: :.: ::: ::::.:: :: .:. ::::: XP_024 MTSTPLQASTQGHLLRHPSSLPELAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 ILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMT ::: ..:::::::: :::.: ::::::::..:::::...::..: :.::::::::. : : XP_024 ILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE6 QVQVSLLALAGKAKTKGLQSGVDIGVKYSEKQERNFDDATMKAGQCVIGLQMGTNKCASQ ::: .:::::. ::::: . :..::::.:::::.:. . .. :. .::::::::: ::: XP_024 QVQSTLLALASMAKTKG--NKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQ 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 SGMTAYGTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTD .::::::::::::::: :.:..:::::::::: :::.:::::::.:.:.. :: . XP_024 QGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGME 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE6 KCDNSSMSLQMGYTQGANQSGQ-VFGLGRQIYDPKYCPQGTVADGAPSGTGDCPDPGEVP .::. ..::::: ..::.: :. :.:: ::.:::::: XP_024 HCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHAHNYYNS 240 250 260 270 280 290 300 pF1KE6 EYPPYYQEEAGY XP_024 A >>XP_024307129 (OMIM: 600806) calponin-1 isoform X2 [Hom (299 aa) initn: 1333 init1: 529 opt: 1104 Z-score: 1207.2 bits: 231.4 E(91774): 1.8e-60 Smith-Waterman score: 1104; 65.0% identity (84.6% similar) in 254 aa overlap (22-274:24-275) 10 20 30 40 50 pF1KE6 MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGT : .::: :.: ::: ::::.:: :: .:. ::::: XP_024 MTSTPLQASTQGHLLRHPSSLPELAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 ILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMT ::: ..:::::::: :::.: ::::::::..:::::...::..: :.::::::::. : : XP_024 ILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE6 QVQVSLLALAGKAKTKGLQSGVDIGVKYSEKQERNFDDATMKAGQCVIGLQMGTNKCASQ ::: .:::::. ::::: . :..::::.:::::.:. . .. :. .::::::::: ::: XP_024 QVQSTLLALASMAKTKG--NKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQ 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 SGMTAYGTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTD .::::::::::::::: :.:..:::::::::: :::.:::::::.:.:.. :: . XP_024 QGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGME 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE6 KCDNSSMSLQMGYTQGANQSGQ-VFGLGRQIYDPKYCPQGTVADGAPSGTGDCPDPGEVP .::. ..::::: ..::.: :. :.:: ::.:::::: XP_024 HCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHAHNYYNS 240 250 260 270 280 290 300 pF1KE6 EYPPYYQEEAGY XP_024 A >>XP_016881778 (OMIM: 600806) calponin-1 isoform X1 [Hom (363 aa) initn: 1333 init1: 529 opt: 1104 Z-score: 1206.0 bits: 231.5 E(91774): 2.1e-60 Smith-Waterman score: 1104; 65.0% identity (84.6% similar) in 254 aa overlap (22-274:88-339) 10 20 30 40 50 pF1KE6 MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQ : .::: :.: ::: ::::.:: :: .:. XP_016 DTERQRCMTSTPLQASTQGHLLRHPSSLPELAQKYDHQREQELREWIEGVTGRRIGNNFM 60 70 80 90 100 110 60 70 80 90 100 110 pF1KE6 KGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDL ::::: ::: ..:::::::: :::.: ::::::::..:::::...::..: :.:::::: XP_016 DGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDL 120 130 140 150 160 170 120 130 140 150 160 170 pF1KE6 FESGNMTQVQVSLLALAGKAKTKGLQSGVDIGVKYSEKQERNFDDATMKAGQCVIGLQMG ::. : :::: .:::::. ::::: . :..::::.:::::.:. . .. :. .:::::: XP_016 FENTNHTQVQSTLLALASMAKTKG--NKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMG 180 190 200 210 220 230 180 190 200 210 220 230 pF1KE6 TNKCASQSGMTAYGTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQVGMTAPGTRRHIY ::: :::.::::::::::::::: :.:..:::::::::: :::.:::::::.:.:. XP_016 TNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIF 240 250 260 270 280 290 240 250 260 270 280 290 pF1KE6 DTKLGTDKCDNSSMSLQMGYTQGANQSGQ-VFGLGRQIYDPKYCPQGTVADGAPSGTGDC . :: ..::. ..::::: ..::.: :. :.:: ::.:::::: XP_016 EPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHH 300 310 320 330 340 350 300 pF1KE6 PDPGEVPEYPPYYQEEAGY XP_016 AHNYYNSA 360 309 residues in 1 query sequences 64092750 residues in 91774 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Jul 16 16:09:19 2019 done: Tue Jul 16 16:09:19 2019 Total Scan time: 3.420 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]