Result of FASTA (omim) for
pF1KE6704
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6704, 1061 aa
1>>>pF1KE6704 1061 - 1061 aa - 1061 aa
Library: /omim/omim.rfq.tfa
65951994 residues in 93482 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3426+/-0.00035; mu= 22.1626+/- 0.022
mean_var=78.9190+/-16.274, 0's: 0 Z-trim(114.7): 195 B-trim: 699 in 1/49
Lambda= 0.144372
statistics sampled from 25586 (25795) to 25586 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.619), E-opt: 0.2 (0.276), width: 16
Scan time: 7.410
The best scores are: opt bits E(93482)
NP_653288 (OMIM: 609648,611762) NACHT, LRR and PYD (1061) 7222 1514.7 0
NP_001264055 (OMIM: 609648,611762) NACHT, LRR and (1062) 7210 1512.2 0
XP_016882949 (OMIM: 609648,611762) NACHT, LRR and (1061) 7183 1506.5 0
XP_016882950 (OMIM: 609648,611762) NACHT, LRR and (1005) 6637 1392.8 0
NP_001264058 (OMIM: 609648,611762) NACHT, LRR and (1004) 6404 1344.3 0
XP_011525782 (OMIM: 609648,611762) NACHT, LRR and (1005) 6392 1341.8 0
XP_016882955 (OMIM: 609648,611762) NACHT, LRR and ( 923) 6277 1317.8 0
XP_016882952 (OMIM: 609648,611762) NACHT, LRR and ( 923) 6277 1317.8 0
XP_016882954 (OMIM: 609648,611762) NACHT, LRR and ( 923) 6277 1317.8 0
XP_016882953 (OMIM: 609648,611762) NACHT, LRR and ( 923) 6277 1317.8 0
XP_016882956 (OMIM: 609648,611762) NACHT, LRR and ( 923) 6277 1317.8 0
XP_011525781 (OMIM: 609648,611762) NACHT, LRR and (1005) 6073 1275.3 0
XP_011525784 (OMIM: 609648,611762) NACHT, LRR and ( 948) 6056 1271.8 0
XP_016882951 (OMIM: 609648,611762) NACHT, LRR and (1004) 5656 1188.5 0
XP_011518346 (OMIM: 609665) NACHT, LRR and PYD dom (1052) 1852 396.2 5.8e-109
XP_024308642 (OMIM: 120100,148200,191900,606416,60 ( 865) 1776 380.3 2.9e-104
XP_016855673 (OMIM: 120100,148200,191900,606416,60 ( 922) 1776 380.3 3e-104
NP_899632 (OMIM: 120100,148200,191900,606416,60711 ( 922) 1776 380.3 3e-104
XP_024308630 (OMIM: 120100,148200,191900,606416,60 ( 922) 1776 380.3 3e-104
NP_001120933 (OMIM: 120100,148200,191900,606416,60 ( 979) 1776 380.3 3.2e-104
NP_001120934 (OMIM: 120100,148200,191900,606416,60 ( 979) 1776 380.3 3.2e-104
XP_016855672 (OMIM: 120100,148200,191900,606416,60 ( 979) 1776 380.3 3.2e-104
NP_001230062 (OMIM: 120100,148200,191900,606416,60 (1034) 1776 380.3 3.3e-104
XP_016855671 (OMIM: 120100,148200,191900,606416,60 (1036) 1776 380.3 3.3e-104
XP_011542350 (OMIM: 120100,148200,191900,606416,60 (1036) 1776 380.3 3.3e-104
NP_004886 (OMIM: 120100,148200,191900,606416,60711 (1036) 1776 380.3 3.3e-104
XP_016855670 (OMIM: 120100,148200,191900,606416,60 (1036) 1776 380.3 3.3e-104
NP_001073289 (OMIM: 120100,148200,191900,606416,60 (1036) 1776 380.3 3.3e-104
XP_006723139 (OMIM: 231090,609661) NACHT, LRR and (1037) 1587 341.0 2.4e-92
NP_001120727 (OMIM: 231090,609661) NACHT, LRR and (1037) 1587 341.0 2.4e-92
XP_011524901 (OMIM: 231090,609661) NACHT, LRR and (1037) 1587 341.0 2.4e-92
XP_006723138 (OMIM: 231090,609661) NACHT, LRR and (1037) 1587 341.0 2.4e-92
XP_011524898 (OMIM: 231090,609661) NACHT, LRR and (1065) 1587 341.0 2.4e-92
NP_996611 (OMIM: 231090,609661) NACHT, LRR and PYD ( 980) 1492 321.2 2e-86
XP_011524903 (OMIM: 231090,609661) NACHT, LRR and (1008) 1492 321.2 2.1e-86
NP_789781 (OMIM: 609659) NACHT, LRR and PYD domain (1048) 1260 272.9 7.6e-72
NP_001303929 (OMIM: 609659) NACHT, LRR and PYD dom (1029) 1256 272.0 1.3e-71
NP_001263629 (OMIM: 609650) NACHT, LRR and PYD dom ( 891) 1251 270.9 2.4e-71
NP_612202 (OMIM: 609650) NACHT, LRR and PYD domain ( 892) 1250 270.7 2.8e-71
XP_016872742 (OMIM: 609650) NACHT, LRR and PYD dom ( 730) 1205 261.3 1.6e-68
XP_011518345 (OMIM: 609662) NACHT, LRR and PYD dom ( 655) 1098 239.0 7.6e-62
NP_789791 (OMIM: 609662) NACHT, LRR and PYD domain ( 655) 1098 239.0 7.6e-62
XP_016881834 (OMIM: 609645) NACHT, LRR and PYD dom ( 937) 1097 238.9 1.1e-61
XP_016881833 (OMIM: 609645) NACHT, LRR and PYD dom ( 938) 1097 238.9 1.2e-61
NP_604393 (OMIM: 609645) NACHT, LRR and PYD domain ( 994) 1097 238.9 1.2e-61
NP_001028225 (OMIM: 606579,606636,615225,617388) N (1375) 1095 238.6 2.1e-61
NP_127500 (OMIM: 606579,606636,615225,617388) NACH (1399) 1095 238.6 2.1e-61
NP_055737 (OMIM: 606579,606636,615225,617388) NACH (1429) 1095 238.6 2.1e-61
NP_127499 (OMIM: 606579,606636,615225,617388) NACH (1443) 1095 238.6 2.1e-61
NP_127497 (OMIM: 606579,606636,615225,617388) NACH (1473) 1095 238.6 2.2e-61
>>NP_653288 (OMIM: 609648,611762) NACHT, LRR and PYD dom (1061 aa)
initn: 7222 init1: 7222 opt: 7222 Z-score: 8122.7 bits: 1514.7 E(93482): 0
Smith-Waterman score: 7222; 100.0% identity (100.0% similar) in 1061 aa overlap (1-1061:1-1061)
10 20 30 40 50 60
pF1KE6 MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 ITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 PRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 PRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 RGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 RGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 QGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 QGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 PSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 PSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 EILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 EILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 GGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 GGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 LRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 LRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 VTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 VTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 SDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 SDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE6 QVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 QVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE6 YRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 YRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE6 GVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 GVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE6 DLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 DLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE6 VLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 VLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE6 LAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 LAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCK
970 980 990 1000 1010 1020
1030 1040 1050 1060
pF1KE6 RLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
:::::::::::::::::::::::::::::::::::::::::
NP_653 RLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
1030 1040 1050 1060
>>NP_001264055 (OMIM: 609648,611762) NACHT, LRR and PYD (1062 aa)
initn: 5722 init1: 4706 opt: 7210 Z-score: 8109.2 bits: 1512.2 E(93482): 0
Smith-Waterman score: 7210; 99.9% identity (99.9% similar) in 1062 aa overlap (1-1061:1-1062)
10 20 30 40 50 60
pF1KE6 MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 PRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 RGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 QGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 PSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 EILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 GGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 LRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 VTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 SDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSA
610 620 630 640 650 660
670 680 690 700 710
pF1KE6 QVLHLYGATYSADGEDRARCSAGAHTLLVQL-PERTVLLDAYSEHLAAALCTNPNLIELS
::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
NP_001 QVLHLYGATYSADGEDRARCSAGAHTLLVQLRPERTVLLDAYSEHLAAALCTNPNLIELS
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE6 LYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSG
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE6 NGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNAL
790 800 810 820 830 840
840 850 860 870 880 890
pF1KE6 EDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDL
850 860 870 880 890 900
900 910 920 930 940 950
pF1KE6 GVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLW
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE6 LLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLC
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060
pF1KE6 KRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
::::::::::::::::::::::::::::::::::::::::::
NP_001 KRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
1030 1040 1050 1060
>>XP_016882949 (OMIM: 609648,611762) NACHT, LRR and PYD (1061 aa)
initn: 4840 init1: 4840 opt: 7183 Z-score: 8078.8 bits: 1506.5 E(93482): 0
Smith-Waterman score: 7183; 99.8% identity (99.8% similar) in 1062 aa overlap (1-1061:1-1061)
10 20 30 40 50 60
pF1KE6 MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 PRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 RGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 QGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 PSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 EILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 GGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 LRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 VTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 SDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSA
610 620 630 640 650 660
670 680 690 700 710
pF1KE6 QVLHLYGATYSADGEDRARCSAGAHTLLVQL-PERTVLLDAYSEHLAAALCTNPNLIELS
::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
XP_016 QVLHLYGATYSADGEDRARCSAGAHTLLVQLRPERTVLLDAYSEHLAAALCTNPNLIELS
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE6 LYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSG
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE6 NGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNAL
790 800 810 820 830 840
840 850 860 870 880 890
pF1KE6 EDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDL
850 860 870 880 890 900
900 910 920 930 940 950
pF1KE6 GVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLW
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE6 LLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLC
:::::::::::::::: :::::::::::::::::::::::::::::::::::::::::::
XP_016 LLAEGLQHPACRLQKL-LDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLC
970 980 990 1000 1010
1020 1030 1040 1050 1060
pF1KE6 KRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
::::::::::::::::::::::::::::::::::::::::::
XP_016 KRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
1020 1030 1040 1050 1060
>>XP_016882950 (OMIM: 609648,611762) NACHT, LRR and PYD (1005 aa)
initn: 5830 init1: 4706 opt: 6637 Z-score: 7464.6 bits: 1392.8 E(93482): 0
Smith-Waterman score: 6696; 94.5% identity (94.5% similar) in 1062 aa overlap (1-1061:1-1005)
10 20 30 40 50 60
pF1KE6 MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 PRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 RGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 QGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 PSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 EILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 GGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 LRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 VTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 SDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSA
610 620 630 640 650 660
670 680 690 700 710
pF1KE6 QVLHLYGATYSADGEDRARCSAGAHTLLVQL-PERTVLLDAYSEHLAAALCTNPNLIELS
::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
XP_016 QVLHLYGATYSADGEDRARCSAGAHTLLVQLRPERTVLLDAYSEHLAAALCTNPNLIELS
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE6 LYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSG
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE6 NGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNAL
790 800 810 820 830 840
840 850 860 870 880 890
pF1KE6 EDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDL
850 860 870 880 890 900
900 910 920 930 940 950
pF1KE6 GVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLW
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE6 LLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLC
::::::::::::::::::
XP_016 LLAEGLQHPACRLQKLWL------------------------------------------
970
1020 1030 1040 1050 1060
pF1KE6 KRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
:::::::::::::::::::::::::::
XP_016 ---------------FGMDLNKMTHSRLAALRVTKPYLDIGC
980 990 1000
>>NP_001264058 (OMIM: 609648,611762) NACHT, LRR and PYD (1004 aa)
initn: 6404 init1: 6404 opt: 6404 Z-score: 7202.3 bits: 1344.3 E(93482): 0
Smith-Waterman score: 6692; 94.6% identity (94.6% similar) in 1061 aa overlap (1-1061:1-1004)
10 20 30 40 50 60
pF1KE6 MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 PRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 RGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 QGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 PSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 EILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 GGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 LRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 VTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 SDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE6 QVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE6 YRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE6 GVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE6 DLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE6 VLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWL
::::::::::::::::::::
NP_001 VLLLCEGLRHPTCKLQTLRL----------------------------------------
910 920
970 980 990 1000 1010 1020
pF1KE6 LAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCK
:::::::::::::::::::::::::::::::::::::::::::
NP_001 -----------------DSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCK
930 940 950 960
1030 1040 1050 1060
pF1KE6 RLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
:::::::::::::::::::::::::::::::::::::::::
NP_001 RLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
970 980 990 1000
>>XP_011525782 (OMIM: 609648,611762) NACHT, LRR and PYD (1005 aa)
initn: 5823 init1: 4706 opt: 6392 Z-score: 7188.8 bits: 1341.8 E(93482): 0
Smith-Waterman score: 6680; 94.5% identity (94.5% similar) in 1062 aa overlap (1-1061:1-1005)
10 20 30 40 50 60
pF1KE6 MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 PRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 RGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 QGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 PSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 EILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 GGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 LRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 VTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 SDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSA
610 620 630 640 650 660
670 680 690 700 710
pF1KE6 QVLHLYGATYSADGEDRARCSAGAHTLLVQL-PERTVLLDAYSEHLAAALCTNPNLIELS
::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
XP_011 QVLHLYGATYSADGEDRARCSAGAHTLLVQLRPERTVLLDAYSEHLAAALCTNPNLIELS
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE6 LYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSG
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE6 NGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNAL
790 800 810 820 830 840
840 850 860 870 880 890
pF1KE6 EDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDL
850 860 870 880 890 900
900 910 920 930 940 950
pF1KE6 GVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLW
:::::::::::::::::::::
XP_011 GVLLLCEGLRHPTCKLQTLRL---------------------------------------
910 920
960 970 980 990 1000 1010
pF1KE6 LLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLC
::::::::::::::::::::::::::::::::::::::::::
XP_011 ------------------DSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLC
930 940 950 960
1020 1030 1040 1050 1060
pF1KE6 KRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
::::::::::::::::::::::::::::::::::::::::::
XP_011 KRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
970 980 990 1000
>>XP_016882955 (OMIM: 609648,611762) NACHT, LRR and PYD (923 aa)
initn: 4789 init1: 3773 opt: 6277 Z-score: 7059.8 bits: 1317.8 E(93482): 0
Smith-Waterman score: 6277; 99.9% identity (99.9% similar) in 923 aa overlap (140-1061:1-923)
110 120 130 140 150 160
pF1KE6 STCLLEVSLVTPRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNP
::::::::::::::::::::::::::::::
XP_016 MEDRNARLGECVNLSHRYTRLLLVKEHSNP
10 20 30
170 180 190 200 210 220
pF1KE6 MQVQQQLLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MQVQQQLLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHK
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE6 VMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERL
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE6 LFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEK
160 170 180 190 200 210
350 360 370 380 390 400
pF1KE6 LHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWV
220 230 240 250 260 270
410 420 430 440 450 460
pF1KE6 VCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGL
280 290 300 310 320 330
470 480 490 500 510 520
pF1KE6 WNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILD
340 350 360 370 380 390
530 540 550 560 570 580
pF1KE6 EGEGGAGPDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGEGGAGPDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKM
400 410 420 430 440 450
590 600 610 620 630 640
pF1KE6 DLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMV
460 470 480 490 500 510
650 660 670 680 690 700
pF1KE6 SSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQL-PERTVLLDAYSEHLAAA
:::::::::::::::::::::::::::::::::::::::::: :::::::::::::::::
XP_016 SSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLRPERTVLLDAYSEHLAAA
520 530 540 550 560 570
710 720 730 740 750 760
pF1KE6 LCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIA
580 590 600 610 620 630
770 780 790 800 810 820
pF1KE6 NKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPH
640 650 660 670 680 690
830 840 850 860 870 880
pF1KE6 LVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRE
700 710 720 730 740 750
890 900 910 920 930 940
pF1KE6 LDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDL
760 770 780 790 800 810
950 960 970 980 990 1000
pF1KE6 SFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNN
820 830 840 850 860 870
1010 1020 1030 1040 1050 1060
pF1KE6 ALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
880 890 900 910 920
>>XP_016882952 (OMIM: 609648,611762) NACHT, LRR and PYD (923 aa)
initn: 4789 init1: 3773 opt: 6277 Z-score: 7059.8 bits: 1317.8 E(93482): 0
Smith-Waterman score: 6277; 99.9% identity (99.9% similar) in 923 aa overlap (140-1061:1-923)
110 120 130 140 150 160
pF1KE6 STCLLEVSLVTPRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNP
::::::::::::::::::::::::::::::
XP_016 MEDRNARLGECVNLSHRYTRLLLVKEHSNP
10 20 30
170 180 190 200 210 220
pF1KE6 MQVQQQLLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MQVQQQLLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHK
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE6 VMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERL
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE6 LFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEK
160 170 180 190 200 210
350 360 370 380 390 400
pF1KE6 LHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWV
220 230 240 250 260 270
410 420 430 440 450 460
pF1KE6 VCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGL
280 290 300 310 320 330
470 480 490 500 510 520
pF1KE6 WNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILD
340 350 360 370 380 390
530 540 550 560 570 580
pF1KE6 EGEGGAGPDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGEGGAGPDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKM
400 410 420 430 440 450
590 600 610 620 630 640
pF1KE6 DLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMV
460 470 480 490 500 510
650 660 670 680 690 700
pF1KE6 SSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQL-PERTVLLDAYSEHLAAA
:::::::::::::::::::::::::::::::::::::::::: :::::::::::::::::
XP_016 SSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLRPERTVLLDAYSEHLAAA
520 530 540 550 560 570
710 720 730 740 750 760
pF1KE6 LCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIA
580 590 600 610 620 630
770 780 790 800 810 820
pF1KE6 NKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPH
640 650 660 670 680 690
830 840 850 860 870 880
pF1KE6 LVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRE
700 710 720 730 740 750
890 900 910 920 930 940
pF1KE6 LDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDL
760 770 780 790 800 810
950 960 970 980 990 1000
pF1KE6 SFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNN
820 830 840 850 860 870
1010 1020 1030 1040 1050 1060
pF1KE6 ALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
880 890 900 910 920
>>XP_016882954 (OMIM: 609648,611762) NACHT, LRR and PYD (923 aa)
initn: 4789 init1: 3773 opt: 6277 Z-score: 7059.8 bits: 1317.8 E(93482): 0
Smith-Waterman score: 6277; 99.9% identity (99.9% similar) in 923 aa overlap (140-1061:1-923)
110 120 130 140 150 160
pF1KE6 STCLLEVSLVTPRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNP
::::::::::::::::::::::::::::::
XP_016 MEDRNARLGECVNLSHRYTRLLLVKEHSNP
10 20 30
170 180 190 200 210 220
pF1KE6 MQVQQQLLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MQVQQQLLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHK
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE6 VMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERL
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE6 LFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEK
160 170 180 190 200 210
350 360 370 380 390 400
pF1KE6 LHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWV
220 230 240 250 260 270
410 420 430 440 450 460
pF1KE6 VCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGL
280 290 300 310 320 330
470 480 490 500 510 520
pF1KE6 WNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILD
340 350 360 370 380 390
530 540 550 560 570 580
pF1KE6 EGEGGAGPDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGEGGAGPDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKM
400 410 420 430 440 450
590 600 610 620 630 640
pF1KE6 DLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMV
460 470 480 490 500 510
650 660 670 680 690 700
pF1KE6 SSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQL-PERTVLLDAYSEHLAAA
:::::::::::::::::::::::::::::::::::::::::: :::::::::::::::::
XP_016 SSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLRPERTVLLDAYSEHLAAA
520 530 540 550 560 570
710 720 730 740 750 760
pF1KE6 LCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIA
580 590 600 610 620 630
770 780 790 800 810 820
pF1KE6 NKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPH
640 650 660 670 680 690
830 840 850 860 870 880
pF1KE6 LVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRE
700 710 720 730 740 750
890 900 910 920 930 940
pF1KE6 LDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDL
760 770 780 790 800 810
950 960 970 980 990 1000
pF1KE6 SFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNN
820 830 840 850 860 870
1010 1020 1030 1040 1050 1060
pF1KE6 ALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
880 890 900 910 920
>>XP_016882953 (OMIM: 609648,611762) NACHT, LRR and PYD (923 aa)
initn: 4789 init1: 3773 opt: 6277 Z-score: 7059.8 bits: 1317.8 E(93482): 0
Smith-Waterman score: 6277; 99.9% identity (99.9% similar) in 923 aa overlap (140-1061:1-923)
110 120 130 140 150 160
pF1KE6 STCLLEVSLVTPRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNP
::::::::::::::::::::::::::::::
XP_016 MEDRNARLGECVNLSHRYTRLLLVKEHSNP
10 20 30
170 180 190 200 210 220
pF1KE6 MQVQQQLLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MQVQQQLLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHK
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE6 VMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERL
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE6 LFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEK
160 170 180 190 200 210
350 360 370 380 390 400
pF1KE6 LHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWV
220 230 240 250 260 270
410 420 430 440 450 460
pF1KE6 VCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGL
280 290 300 310 320 330
470 480 490 500 510 520
pF1KE6 WNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILD
340 350 360 370 380 390
530 540 550 560 570 580
pF1KE6 EGEGGAGPDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGEGGAGPDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKM
400 410 420 430 440 450
590 600 610 620 630 640
pF1KE6 DLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMV
460 470 480 490 500 510
650 660 670 680 690 700
pF1KE6 SSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQL-PERTVLLDAYSEHLAAA
:::::::::::::::::::::::::::::::::::::::::: :::::::::::::::::
XP_016 SSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLRPERTVLLDAYSEHLAAA
520 530 540 550 560 570
710 720 730 740 750 760
pF1KE6 LCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIA
580 590 600 610 620 630
770 780 790 800 810 820
pF1KE6 NKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPH
640 650 660 670 680 690
830 840 850 860 870 880
pF1KE6 LVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRE
700 710 720 730 740 750
890 900 910 920 930 940
pF1KE6 LDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDL
760 770 780 790 800 810
950 960 970 980 990 1000
pF1KE6 SFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNN
820 830 840 850 860 870
1010 1020 1030 1040 1050 1060
pF1KE6 ALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
880 890 900 910 920
1061 residues in 1 query sequences
65951994 residues in 93482 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Jun 19 14:26:16 2019 done: Wed Jun 19 14:26:17 2019
Total Scan time: 7.410 Total Display time: 0.270
Function used was FASTA [36.3.4 Apr, 2011]