FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9424, 361 aa 1>>>pF1KE9424 361 - 361 aa - 361 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8948+/-0.000485; mu= 19.0391+/- 0.030 mean_var=123.8080+/-31.488, 0's: 0 Z-trim(109.4): 467 B-trim: 1053 in 1/49 Lambda= 0.115266 statistics sampled from 17017 (17597) to 17017 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.55), E-opt: 0.2 (0.206), width: 16 Scan time: 7.700 The best scores are: opt bits E(85289) NP_001182684 (OMIM: 607514,609044) free fatty acid ( 361) 2378 407.6 2.2e-113 XP_011538048 (OMIM: 607514,609044) PREDICTED: free ( 240) 1519 264.5 1.8e-70 NP_859529 (OMIM: 607514,609044) free fatty acid re ( 377) 1521 265.1 1.8e-70 NP_000901 (OMIM: 162642) neuropeptide Y receptor t ( 381) 340 68.7 2.4e-11 XP_005263090 (OMIM: 162642) PREDICTED: neuropeptid ( 381) 340 68.7 2.4e-11 XP_005263091 (OMIM: 162642) PREDICTED: neuropeptid ( 381) 340 68.7 2.4e-11 NP_064552 (OMIM: 605108) neuromedin-U receptor 2 [ ( 415) 306 63.1 1.3e-09 XP_016881180 (OMIM: 600377) PREDICTED: galanin rec ( 269) 298 61.5 2.5e-09 NP_004239 (OMIM: 600895) prolactin-releasing pepti ( 370) 297 61.5 3.4e-09 NP_937822 (OMIM: 606925) pyroglutamylated RFamide ( 431) 294 61.1 5.2e-09 NP_001048 (OMIM: 162321) substance-K receptor [Hom ( 398) 292 60.8 6.3e-09 NP_001471 (OMIM: 600377) galanin receptor type 1 [ ( 349) 291 60.5 6.5e-09 NP_002502 (OMIM: 162341) neuromedin-B receptor iso ( 390) 291 60.6 7e-09 XP_005263088 (OMIM: 162641) PREDICTED: neuropeptid ( 384) 290 60.4 7.7e-09 XP_011530312 (OMIM: 162641) PREDICTED: neuropeptid ( 384) 290 60.4 7.7e-09 NP_000900 (OMIM: 162641) neuropeptide Y receptor t ( 384) 290 60.4 7.7e-09 NP_001718 (OMIM: 300107) bombesin receptor subtype ( 399) 288 60.1 1e-08 NP_005152 (OMIM: 600052) apelin receptor [Homo sap ( 380) 280 58.7 2.4e-08 NP_071429 (OMIM: 607448) neuropeptide FF receptor ( 430) 279 58.6 2.9e-08 NP_795344 (OMIM: 118445) gastrin/cholecystokinin t ( 447) 276 58.2 4.2e-08 XP_005253267 (OMIM: 118445) PREDICTED: gastrin/cho ( 516) 276 58.3 4.6e-08 NP_859528 (OMIM: 609042) opsin-5 [Homo sapiens] ( 354) 270 57.0 7.4e-08 XP_016865905 (OMIM: 609042) PREDICTED: opsin-5 iso ( 408) 270 57.1 8e-08 NP_444264 (OMIM: 607449) neuropeptide FF receptor ( 420) 269 57.0 9.2e-08 NP_001138228 (OMIM: 607449) neuropeptide FF recept ( 423) 269 57.0 9.2e-08 NP_004876 (OMIM: 607449) neuropeptide FF receptor ( 522) 269 57.1 1e-07 NP_000721 (OMIM: 118444) cholecystokinin receptor ( 428) 268 56.8 1e-07 NP_001043 (OMIM: 182454) somatostatin receptor typ ( 388) 267 56.6 1.1e-07 XP_011535972 (OMIM: 605108) PREDICTED: neuromedin- ( 321) 263 55.8 1.6e-07 NP_003848 (OMIM: 603691) galanin receptor type 2 [ ( 387) 263 55.9 1.7e-07 XP_016884412 (OMIM: 182453) PREDICTED: somatostati ( 418) 263 56.0 1.8e-07 XP_016884413 (OMIM: 182453) PREDICTED: somatostati ( 418) 263 56.0 1.8e-07 XP_005261778 (OMIM: 182453) PREDICTED: somatostati ( 418) 263 56.0 1.8e-07 NP_001265616 (OMIM: 182453) somatostatin receptor ( 418) 263 56.0 1.8e-07 XP_006724374 (OMIM: 182453) PREDICTED: somatostati ( 418) 263 56.0 1.8e-07 XP_011528651 (OMIM: 182453) PREDICTED: somatostati ( 418) 263 56.0 1.8e-07 NP_001042 (OMIM: 182453) somatostatin receptor typ ( 418) 263 56.0 1.8e-07 XP_006713023 (OMIM: 601268) PREDICTED: C-C chemoki ( 355) 260 55.4 2.4e-07 NP_847899 (OMIM: 601268) C-C chemokine receptor ty ( 355) 260 55.4 2.4e-07 XP_011531637 (OMIM: 601268) PREDICTED: C-C chemoki ( 355) 260 55.4 2.4e-07 NP_001828 (OMIM: 601268) C-C chemokine receptor ty ( 355) 260 55.4 2.4e-07 NP_001158152 (OMIM: 601268) C-C chemokine receptor ( 373) 260 55.4 2.4e-07 NP_847898 (OMIM: 601268) C-C chemokine receptor ty ( 376) 260 55.4 2.4e-07 XP_016861175 (OMIM: 601268) PREDICTED: C-C chemoki ( 410) 260 55.5 2.6e-07 XP_016861174 (OMIM: 601268) PREDICTED: C-C chemoki ( 410) 260 55.5 2.6e-07 NP_778227 (OMIM: 608282) trace amine-associated re ( 348) 259 55.2 2.6e-07 NP_003982 (OMIM: 131244,277580,600155,600501) endo ( 436) 259 55.3 3e-07 NP_055441 (OMIM: 604849) trace amine-associated re ( 306) 254 54.3 4.3e-07 NP_001028252 (OMIM: 604849) trace amine-associated ( 351) 254 54.4 4.7e-07 NP_001495 (OMIM: 300574) C-X-C chemokine receptor ( 368) 254 54.4 4.8e-07 >>NP_001182684 (OMIM: 607514,609044) free fatty acid rec (361 aa) initn: 2378 init1: 2378 opt: 2378 Z-score: 2156.5 bits: 407.6 E(85289): 2.2e-113 Smith-Waterman score: 2378; 100.0% identity (100.0% similar) in 361 aa overlap (1-361:1-361) 10 20 30 40 50 60 pF1KE9 MSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 ALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 SGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 PQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 LTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 SLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIIS 310 320 330 340 350 360 pF1KE9 G : NP_001 G >>XP_011538048 (OMIM: 607514,609044) PREDICTED: free fat (240 aa) initn: 1519 init1: 1519 opt: 1519 Z-score: 1386.2 bits: 264.5 E(85289): 1.8e-70 Smith-Waterman score: 1519; 100.0% identity (100.0% similar) in 232 aa overlap (1-232:1-232) 10 20 30 40 50 60 pF1KE9 MSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 ALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 SGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 PQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKR :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQARVHLEKF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 LTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWP >>NP_859529 (OMIM: 607514,609044) free fatty acid recept (377 aa) initn: 1521 init1: 1521 opt: 1521 Z-score: 1386.1 bits: 265.1 E(85289): 1.8e-70 Smith-Waterman score: 2336; 95.8% identity (95.8% similar) in 377 aa overlap (1-361:1-377) 10 20 30 40 50 60 pF1KE9 MSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_859 MSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 ALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_859 ALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 SGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_859 SGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVV 130 140 150 160 170 180 190 200 210 220 230 pF1KE9 PQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQ-------- :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_859 PQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQTSEHLLDA 190 200 210 220 230 240 240 250 260 270 280 pF1KE9 --------ITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITI :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_859 RAVVTHSEITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITI 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE9 LLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_859 LLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGA 310 320 330 340 350 360 350 360 pF1KE9 ILTDTSVKRNDLSIISG ::::::::::::::::: NP_859 ILTDTSVKRNDLSIISG 370 >>NP_000901 (OMIM: 162642) neuropeptide Y receptor type (381 aa) initn: 249 init1: 127 opt: 340 Z-score: 324.6 bits: 68.7 E(85289): 2.4e-11 Smith-Waterman score: 348; 29.1% identity (57.3% similar) in 323 aa overlap (46-351:52-355) 20 30 40 50 60 70 pF1KE9 SLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIF-AVSLLG----NVCALVLVARRRR ::.: . .. ::: .. :.. . NP_000 YGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSM 30 40 50 60 70 80 80 90 100 110 120 pF1KE9 RGATACLVLNLFCADLLFIS-AIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTL : .: .. :: :::: . .:..:. : .::: :::. :.. :. .:. .:: NP_000 RTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITL 90 100 110 120 130 140 130 140 150 160 170 180 pF1KE9 AAVSLERMVCIV-HLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRV-VPQRLPGA ....:.: ::: ::. . ..: ....: :: ::. : :: .: . . . .: NP_000 TVIALDRHRCIVYHLESKI---SKRISFLIIGLAWGISALLASPLAIFREYSLIEIIP-- 150 160 170 180 190 190 200 210 220 230 240 pF1KE9 DQEISICTLIWP----TIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLTV : :: :: :: .: : . ...: . . ...: .: .::..: . : .... NP_000 DFEIVACTEKWPGEEKSIYGTV-YSLSSLLILYVLPLGIISFSYTRIWSKLK---NHVSP 200 210 220 230 240 250 250 260 270 280 290 300 pF1KE9 SLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLF . : .. :: : :. .. : ..: : . : :. : . :.. :: . .: NP_000 GAANDHYHQRR--QKTTKM---LVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIF 260 270 280 290 300 310 320 330 340 350 pF1KE9 --FWVVAF--TFANSALNPILYNMTLCRNEWKKIFCCFWFPEK-GAILTDTSVKRNDLSI : ..:. ::: ::.::. . : : .. : .. :: ...:: NP_000 TVFHIIAMCSTFA----NPLLYGW-MNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKN 310 320 330 340 350 360 360 pF1KE9 ISG NP_000 LEVRKNSGPNDSFTEATNV 370 380 >>XP_005263090 (OMIM: 162642) PREDICTED: neuropeptide Y (381 aa) initn: 249 init1: 127 opt: 340 Z-score: 324.6 bits: 68.7 E(85289): 2.4e-11 Smith-Waterman score: 348; 29.1% identity (57.3% similar) in 323 aa overlap (46-351:52-355) 20 30 40 50 60 70 pF1KE9 SLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIF-AVSLLG----NVCALVLVARRRR ::.: . .. ::: .. :.. . XP_005 YGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSM 30 40 50 60 70 80 80 90 100 110 120 pF1KE9 RGATACLVLNLFCADLLFIS-AIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTL : .: .. :: :::: . .:..:. : .::: :::. :.. :. .:. .:: XP_005 RTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITL 90 100 110 120 130 140 130 140 150 160 170 180 pF1KE9 AAVSLERMVCIV-HLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRV-VPQRLPGA ....:.: ::: ::. . ..: ....: :: ::. : :: .: . . . .: XP_005 TVIALDRHRCIVYHLESKI---SKRISFLIIGLAWGISALLASPLAIFREYSLIEIIP-- 150 160 170 180 190 190 200 210 220 230 240 pF1KE9 DQEISICTLIWP----TIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLTV : :: :: :: .: : . ...: . . ...: .: .::..: . : .... XP_005 DFEIVACTEKWPGEEKSIYGTV-YSLSSLLILYVLPLGIISFSYTRIWSKLK---NHVSP 200 210 220 230 240 250 250 260 270 280 290 300 pF1KE9 SLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLF . : .. :: : :. .. : ..: : . : :. : . :.. :: . .: XP_005 GAANDHYHQRR--QKTTKM---LVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIF 260 270 280 290 300 310 320 330 340 350 pF1KE9 --FWVVAF--TFANSALNPILYNMTLCRNEWKKIFCCFWFPEK-GAILTDTSVKRNDLSI : ..:. ::: ::.::. . : : .. : .. :: ...:: XP_005 TVFHIIAMCSTFA----NPLLYGW-MNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKN 310 320 330 340 350 360 360 pF1KE9 ISG XP_005 LEVRKNSGPNDSFTEATNV 370 380 >>XP_005263091 (OMIM: 162642) PREDICTED: neuropeptide Y (381 aa) initn: 249 init1: 127 opt: 340 Z-score: 324.6 bits: 68.7 E(85289): 2.4e-11 Smith-Waterman score: 348; 29.1% identity (57.3% similar) in 323 aa overlap (46-351:52-355) 20 30 40 50 60 70 pF1KE9 SLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIF-AVSLLG----NVCALVLVARRRR ::.: . .. ::: .. :.. . XP_005 YGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSM 30 40 50 60 70 80 80 90 100 110 120 pF1KE9 RGATACLVLNLFCADLLFIS-AIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTL : .: .. :: :::: . .:..:. : .::: :::. :.. :. .:. .:: XP_005 RTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITL 90 100 110 120 130 140 130 140 150 160 170 180 pF1KE9 AAVSLERMVCIV-HLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRV-VPQRLPGA ....:.: ::: ::. . ..: ....: :: ::. : :: .: . . . .: XP_005 TVIALDRHRCIVYHLESKI---SKRISFLIIGLAWGISALLASPLAIFREYSLIEIIP-- 150 160 170 180 190 190 200 210 220 230 240 pF1KE9 DQEISICTLIWP----TIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLTV : :: :: :: .: : . ...: . . ...: .: .::..: . : .... XP_005 DFEIVACTEKWPGEEKSIYGTV-YSLSSLLILYVLPLGIISFSYTRIWSKLK---NHVSP 200 210 220 230 240 250 250 260 270 280 290 300 pF1KE9 SLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLF . : .. :: : :. .. : ..: : . : :. : . :.. :: . .: XP_005 GAANDHYHQRR--QKTTKM---LVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIF 260 270 280 290 300 310 320 330 340 350 pF1KE9 --FWVVAF--TFANSALNPILYNMTLCRNEWKKIFCCFWFPEK-GAILTDTSVKRNDLSI : ..:. ::: ::.::. . : : .. : .. :: ...:: XP_005 TVFHIIAMCSTFA----NPLLYGW-MNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKN 310 320 330 340 350 360 360 pF1KE9 ISG XP_005 LEVRKNSGPNDSFTEATNV 370 380 >>NP_064552 (OMIM: 605108) neuromedin-U receptor 2 [Homo (415 aa) initn: 210 init1: 142 opt: 306 Z-score: 293.7 bits: 63.1 E(85289): 1.3e-09 Smith-Waterman score: 306; 27.9% identity (59.2% similar) in 326 aa overlap (13-323:21-329) 10 20 30 40 50 pF1KE9 MSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFA :... .... . :. . .: .. ..: : : ::. NP_064 MSGMEKLQNASWIYQQKLEDPFQKHLNSTEEYLAFLCGPRRSHFFLPVSV---VYVPIFV 10 20 30 40 50 60 70 80 90 100 pF1KE9 VSLLGNV--CALVLVARRRRRGATACLVLNLFCADLL-FISAIPLVLAVRWTE-AWLLGP :...::: : ::.. .. . : ...: .::: .. ..:: . : . .:.:: NP_064 VGVIGNVLVC-LVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGP 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE9 VACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAV :.:.. .. ..::....::.::.: :.: :. :: .:...::.:.. NP_064 VGCYFKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRILGIVWGFSVL 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE9 AALPLC----VFFRVVPQR--LPGADQEISICTLIWPT-IPGEISWDVSFVTLNFLVPGL .:: . :. :. .::. . ::.: : : . : .:: : .:.: NP_064 FSLPNTSIHGIKFHYFPNGSLVPGS----ATCTVIKPMWIYNFIIQVTSF--LFYLLPMT 180 190 200 210 220 230 230 240 250 260 270 pF1KE9 VIVISYSKILQITKASRKRLTVSLAYSESHQIRVSQQDFR--LFRTLFLLMVSFFIMWSP :: . : . : : . :: .:.. :. : . . ::.:.. : : :.: NP_064 VISVLYYLM-----ALRLKKDKSLEADEGNA--NIQRPCRKSVNKMLFVLVLVFAICWAP 240 250 260 270 280 280 290 300 310 320 330 pF1KE9 IIITILLI-LIQNFKQDLVIWPSLFFWVVA-FTFANSALNPILYNMTLCRNEWKKIFCCF . : :.. ........:. .: : . : . .::.:::.::. NP_064 FHIDRLFFSFVEEWSESLAAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQAAFQNVIS 290 300 310 320 330 340 340 350 360 pF1KE9 WFPEKGAILTDTSVKRNDLSIISG NP_064 SFHKQWHSQHDPQLPPAQRNIFLTECHFVELTEDIGPQFPCQSSMHNSHLPAALSSEQMS 350 360 370 380 390 400 >>XP_016881180 (OMIM: 600377) PREDICTED: galanin recepto (269 aa) initn: 224 init1: 159 opt: 298 Z-score: 288.4 bits: 61.5 E(85289): 2.5e-09 Smith-Waterman score: 298; 30.0% identity (62.1% similar) in 240 aa overlap (42-274:35-265) 20 30 40 50 60 70 pF1KE9 APLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRR- : .:. ::::...::: .....:: . XP_016 VGNLSEGNASWPEPPAPEPGPLFGIGVENFVTLVVFGLIFALGVLGNSLVITVLARSKPG 10 20 30 40 50 60 80 90 100 110 120 pF1KE9 --RGATACLVLNLFCADLLFIS-AIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTIL :..: ..::: ::: .. ::. .: .:.:: :... : .:.: :.:. XP_016 KPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 TLAAVSLERMVCIVHLQRGVRGPGRRARAVLLAL--IWGYSAVAALPLCVFFRVVPQRLP ::::.:..:.: ::: .:. . : .: .::.. ::. : . : :. . : XP_016 TLAAMSVDRYVAIVHSRRS--SSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPR-- 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 GADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLTVSL ...: ..: :: . .. : ....:.: :.: . :.:.:. . . : .. . XP_016 ASNQ--TFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKK- 190 200 210 220 230 250 260 270 280 290 300 pF1KE9 AYSESHQIRVSQQDFR-LFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFF ::. . .:. .: .... ::..: XP_016 --SEASKKKVQGASFGWIYHSGVWRMVALFSQIH 240 250 260 >>NP_004239 (OMIM: 600895) prolactin-releasing peptide r (370 aa) initn: 202 init1: 97 opt: 297 Z-score: 286.1 bits: 61.5 E(85289): 3.4e-09 Smith-Waterman score: 337; 27.5% identity (56.7% similar) in 353 aa overlap (2-344:24-358) 10 20 30 pF1KE9 MSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLV .: : ..: :. :. :.... :.: NP_004 MASSTTRGPRVSDLFSGLPPAVTTPANQSAEASAGNGSVAGADAPAVTPFQSLQLVHQLK 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE9 LAAVETTVLVLIFAVSLLGNVCALVLVARRRRR--GATACLVLNLFCADLLFISA-IPLV : .:.. :.:.:: : :::: : :: ..: :. :: .:.:. .: .::. NP_004 GLIVLLYSVVVV--VGLVGN-CLLVLVIARVRRLHNVTNFLIGNLALSDVLMCTACVPLT 70 80 90 100 110 100 110 120 130 140 150 pF1KE9 LAVRWT-EAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRA :: . ..:..: :::.:... .. :...::......:.: .:: : : . : NP_004 LAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLR--RRISLRL 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE9 RAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGE---ISWDVSF : . ::. ::: ::: : : . : ... .: .: . . .: . . NP_004 SAYAVLAIWALSAVLALPAAVHTYHVELK-P---HDVRLCEEFWGSQERQRQLYAWGLLL 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE9 VTLNFLVPGLVIVISYSKILQITKASRKRLTVS-LAYSESHQIRVSQQDFRLFRTLFLLM :: .:.: :::..:: .... :.:.. . .. :.. :. .. : : : ... NP_004 VT--YLLPLLVILLSY---VRVSVKLRNRVVPGCVTQSQADWDRARRR--RTFCLLVVVV 240 250 260 270 280 280 290 300 310 320 pF1KE9 VSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTL--CRN : : . : :. . :: .. : . . . ...... ::..: :. NP_004 VVFAVCWLPLHVFNLLRDLDPHAIDPYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFRE 290 300 310 320 330 340 330 340 350 360 pF1KE9 EWKKIFCCFWFPEKGAILTDTSVKRNDLSIISG : .:.. : :.: : NP_004 ELRKLLVA-W-PRKIAPHGQNMTVSVVI 350 360 370 >>NP_937822 (OMIM: 606925) pyroglutamylated RFamide pept (431 aa) initn: 222 init1: 146 opt: 294 Z-score: 282.7 bits: 61.1 E(85289): 5.2e-09 Smith-Waterman score: 294; 26.2% identity (58.5% similar) in 313 aa overlap (36-336:43-350) 10 20 30 40 50 60 pF1KE9 ARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLV : :: : : : ::::..:.::. .. .: NP_937 RLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGV--LIFALALFGNALVFYVV 20 30 40 50 60 70 70 80 90 100 110 120 pF1KE9 ARRRR-RGATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGS .: . : .: .. .: .:::. . ::... .. :: : :... .:.. . NP_937 TRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVV 80 90 100 110 120 130 130 140 150 160 170 180 pF1KE9 VTILTLAAVSLERMVCIVH-LQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQ . :::.. ...:: .:: .. . .::: . .:...: ..... :. . . NP_937 TEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFT-MLGVVWLVAVIVGSPM-WHVQQLEI 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 RLPGADQEISICTLIWPTIPGEISWDVSFV-TLNFLVPGLVIVISYSKILQITKASRKRL . .. :: : : : . . ..:. .. ::.: .:..: :::: .::. NP_937 KYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKI-GYELWIKKRV 190 200 210 220 230 240 250 260 270 280 290 pF1KE9 TVSLAYSESHQIRVSQQDFRLFRTLFLLM--VSFF-IMWSPIIITILLILIQNFKQ--DL . . : ..:. . :...... :..: . :.:. .. ..: .::.. : NP_937 GDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDD 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE9 VIWPSLFFWVVAFTFANSALNPILY---NMTLCRNEWKKIFCCFWFPEKGAILTDTSVKR : .: : . :.:: :::.: : .. .: . . : NP_937 VTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGI 310 320 330 340 350 360 360 pF1KE9 NDLSIISG NP_937 TMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSELAENSPL 370 380 390 400 410 420 361 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 12:36:56 2016 done: Sun Nov 6 12:36:57 2016 Total Scan time: 7.700 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]