FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9630, 1085 aa 1>>>pF1KE9630 1085 - 1085 aa - 1085 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.4869+/-0.000494; mu= 2.1565+/- 0.031 mean_var=225.2991+/-47.379, 0's: 0 Z-trim(115.1): 43 B-trim: 0 in 0/58 Lambda= 0.085447 statistics sampled from 25380 (25405) to 25380 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.641), E-opt: 0.2 (0.298), width: 16 Scan time: 11.030 The best scores are: opt bits E(85289) NP_004327 (OMIM: 602452) mitotic checkpoint serine (1085) 7305 914.8 0 NP_001265545 (OMIM: 602452) mitotic checkpoint ser (1065) 7100 889.5 0 NP_001265546 (OMIM: 602452) mitotic checkpoint ser (1028) 5858 736.4 2e-211 NP_001202 (OMIM: 114500,176430,257300,602860) mito (1050) 392 62.6 1.4e-08 >>NP_004327 (OMIM: 602452) mitotic checkpoint serine/thr (1085 aa) initn: 7305 init1: 7305 opt: 7305 Z-score: 4880.6 bits: 914.8 E(85289): 0 Smith-Waterman score: 7305; 100.0% identity (100.0% similar) in 1085 aa overlap (1-1085:1-1085) 10 20 30 40 50 60 pF1KE9 MDTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEYLITLLEHLMKEFLDKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MDTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEYLITLLEHLMKEFLDKK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 KYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 VLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSEPLHNVQVLNQMITSKSNPGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSEPLHNVQVLNQMITSKSNPGN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 NMACISKNQGSELSGVISSACDKESNMERRVITISKSEYSVHSSLASKVDVEQVVMYCKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 NMACISKNQGSELSGVISSACDKESNMERRVITISKSEYSVHSSLASKVDVEQVVMYCKE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 KLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYMKRKEANAFEEQLLKQKMDELHKKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYMKRKEANAFEEQLLKQKMDELHKKL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 HQVVETSHEDLPASQERSEVNPARMGPSVGSQQELRAPCLPVTYQQTPVNMEKNPREAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 HQVVETSHEDLPASQERSEVNPARMGPSVGSQQELRAPCLPVTYQQTPVNMEKNPREAPP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 VVPPLANAISAALVSPATSQSIAPPVPLKAQTVTDSMFAVASKDAGCVNKSTHEFKPQSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VVPPLANAISAALVSPATSQSIAPPVPLKAQTVTDSMFAVASKDAGCVNKSTHEFKPQSG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 AEIKEGCETHKVANTSSFHTTPNTSLGMVQATPSKVQPSPTVHTKEALGFIMNMFQAPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AEIKEGCETHKVANTSSFHTTPNTSLGMVQATPSKVQPSPTVHTKEALGFIMNMFQAPTL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE9 PDISDDKDEWQSLDQNEDAFEAQFQKNVRSSGAWGVNKIISSLSSAFHVFEDGNKENYGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PDISDDKDEWQSLDQNEDAFEAQFQKNVRSSGAWGVNKIISSLSSAFHVFEDGNKENYGL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE9 PQPKNKPTGARTFGERSVSRLPSKPKEEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PQPKNKPTGARTFGERSVSRLPSKPKEEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDF 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE9 TSAAQLASTPFHKLPVESVHILEDKENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TSAAQLASTPFHKLPVESVHILEDKENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE9 SPKQALSSHMYSASLLRLSQPAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SPKQALSSHMYSASLLRLSQPAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE9 EWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEF 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE9 QLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMER 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE9 LKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMR 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE9 MLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGT 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE9 IFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 IFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFR 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE9 RLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLEC 1030 1040 1050 1060 1070 1080 pF1KE9 KRSRK ::::: NP_004 KRSRK >>NP_001265545 (OMIM: 602452) mitotic checkpoint serine/ (1065 aa) initn: 7100 init1: 7100 opt: 7100 Z-score: 4744.1 bits: 889.5 E(85289): 0 Smith-Waterman score: 7109; 98.2% identity (98.2% similar) in 1085 aa overlap (1-1085:1-1065) 10 20 30 40 50 60 pF1KE9 MDTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEYLITLLEHLMKEFLDKK ::::::::: ::::::::::::::::::::::::::::::: NP_001 MDTPENVLQ--------------------YIQWVEENFPENKEYLITLLEHLMKEFLDKK 10 20 30 40 70 80 90 100 110 120 pF1KE9 KYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASA 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE9 VLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSEPLHNVQVLNQMITSKSNPGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSEPLHNVQVLNQMITSKSNPGN 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE9 NMACISKNQGSELSGVISSACDKESNMERRVITISKSEYSVHSSLASKVDVEQVVMYCKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NMACISKNQGSELSGVISSACDKESNMERRVITISKSEYSVHSSLASKVDVEQVVMYCKE 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE9 KLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYMKRKEANAFEEQLLKQKMDELHKKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYMKRKEANAFEEQLLKQKMDELHKKL 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE9 HQVVETSHEDLPASQERSEVNPARMGPSVGSQQELRAPCLPVTYQQTPVNMEKNPREAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HQVVETSHEDLPASQERSEVNPARMGPSVGSQQELRAPCLPVTYQQTPVNMEKNPREAPP 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE9 VVPPLANAISAALVSPATSQSIAPPVPLKAQTVTDSMFAVASKDAGCVNKSTHEFKPQSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVPPLANAISAALVSPATSQSIAPPVPLKAQTVTDSMFAVASKDAGCVNKSTHEFKPQSG 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE9 AEIKEGCETHKVANTSSFHTTPNTSLGMVQATPSKVQPSPTVHTKEALGFIMNMFQAPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEIKEGCETHKVANTSSFHTTPNTSLGMVQATPSKVQPSPTVHTKEALGFIMNMFQAPTL 410 420 430 440 450 460 490 500 510 520 530 540 pF1KE9 PDISDDKDEWQSLDQNEDAFEAQFQKNVRSSGAWGVNKIISSLSSAFHVFEDGNKENYGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDISDDKDEWQSLDQNEDAFEAQFQKNVRSSGAWGVNKIISSLSSAFHVFEDGNKENYGL 470 480 490 500 510 520 550 560 570 580 590 600 pF1KE9 PQPKNKPTGARTFGERSVSRLPSKPKEEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQPKNKPTGARTFGERSVSRLPSKPKEEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDF 530 540 550 560 570 580 610 620 630 640 650 660 pF1KE9 TSAAQLASTPFHKLPVESVHILEDKENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSAAQLASTPFHKLPVESVHILEDKENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEK 590 600 610 620 630 640 670 680 690 700 710 720 pF1KE9 SPKQALSSHMYSASLLRLSQPAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPKQALSSHMYSASLLRLSQPAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQA 650 660 670 680 690 700 730 740 750 760 770 780 pF1KE9 EWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEF 710 720 730 740 750 760 790 800 810 820 830 840 pF1KE9 QLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMER 770 780 790 800 810 820 850 860 870 880 890 900 pF1KE9 LKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMR 830 840 850 860 870 880 910 920 930 940 950 960 pF1KE9 MLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGT 890 900 910 920 930 940 970 980 990 1000 1010 1020 pF1KE9 IFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFR 950 960 970 980 990 1000 1030 1040 1050 1060 1070 1080 pF1KE9 RLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLEC 1010 1020 1030 1040 1050 1060 pF1KE9 KRSRK ::::: NP_001 KRSRK >>NP_001265546 (OMIM: 602452) mitotic checkpoint serine/ (1028 aa) initn: 6906 init1: 5858 opt: 5858 Z-score: 3916.9 bits: 736.4 E(85289): 2e-211 Smith-Waterman score: 6794; 94.7% identity (94.7% similar) in 1085 aa overlap (1-1085:1-1028) 10 20 30 40 50 60 pF1KE9 MDTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEYLITLLEHLMKEFLDKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEYLITLLEHLMKEFLDKK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 KYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 VLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSEPLHNVQVLNQMITSKSNPGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSEPLHNVQVLNQMITSKSNPGN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 NMACISKNQGSELSGVISSACDKESNMERRVITISKSEYSVHSSLASKVDVEQVVMYCKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NMACISKNQGSELSGVISSACDKESNMERRVITISKSEYSVHSSLASKVDVEQVVMYCKE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 KLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYMKRKEANAFEEQLLKQKMDELHKKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYMKRKEANAFEEQLLKQKMDELHKKL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 HQVVETSHEDLPASQERSEVNPARMGPSVGSQQELRAPCLPVTYQQTPVNMEKNPREAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HQVVETSHEDLPASQERSEVNPARMGPSVGSQQELRAPCLPVTYQQTPVNMEKNPREAPP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 VVPPLANAISAALVSPATSQSIAPPVPLKAQTVTDSMFAVASKDAGCVNKSTHEFKPQSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVPPLANAISAALVSPATSQSIAPPVPLKAQTVTDSMFAVASKDAGCVNKSTHEFKPQSG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 AEIKEGCETHKVANTSSFHTTPNTSLGMVQATPSKVQPSPTVHTKEALGFIMNMFQAPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEIKEGCETHKVANTSSFHTTPNTSLGMVQATPSKVQPSPTVHTKEALGFIMNMFQAPTL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE9 PDISDDKDEWQSLDQNEDAFEAQFQKNVRSSGAWGVNKIISSLSSAFHVFEDGNKENYGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDISDDKDEWQSLDQNEDAFEAQFQKNVRSSGAWGVNKIISSLSSAFHVFEDGNKENYGL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE9 PQPKNKPTGARTFGERSVSRLPSKPKEEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQPKNKPTGARTFGERSVSRLPSKPKEEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDF 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE9 TSAAQLASTPFHKLPVESVHILEDKENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSAAQLASTPFHKLPVESVHILEDKENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE9 SPKQALSSHMYSASLLRLSQPAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPKQALSSHMYSASLLRLSQPAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE9 EWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEF 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE9 QLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMER 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE9 LKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMR ::::::::::::::::::::::::::::::::::: NP_001 LKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLL------------------------- 850 860 870 910 920 930 940 950 960 pF1KE9 MLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGT :::::::::::::::::::::::::::: NP_001 --------------------------------DDEDDLSAGLALIDLGQSIDMKLFPKGT 880 890 900 970 980 990 1000 1010 1020 pF1KE9 IFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFR 910 920 930 940 950 960 1030 1040 1050 1060 1070 1080 pF1KE9 RLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLEC 970 980 990 1000 1010 1020 pF1KE9 KRSRK ::::: NP_001 KRSRK >>NP_001202 (OMIM: 114500,176430,257300,602860) mitotic (1050 aa) initn: 848 init1: 276 opt: 392 Z-score: 275.2 bits: 62.6 E(85289): 1.4e-08 Smith-Waterman score: 714; 23.6% identity (54.1% similar) in 1097 aa overlap (6-1065:53-1033) 10 20 30 pF1KE9 MDTPENVLQM----LEAHMQSYKGNDPLGEWERYI :.::. .: ... : ::::: :.::: NP_001 ELSKENVQPLRQGRIMSTLQGALAQESACNNTLQQQKRAFEYEIRFYTGNDPLDVWDRYI 30 40 50 60 70 80 40 50 60 70 80 pF1KE9 QWVEENFPEN-KEY-LITLLEHLMKEFLDKKKYHNDPRFISYCLKFAEYNSDLHQFFEFL .:.:.:.:.. :: . ::::. .. . .:.:..::::.. ::... .. ... .: NP_001 SWTEQNYPQGGKESNMSTLLERAVEALQGEKRYYSDPRFLNLWLKLGRLCNEPLDMYSYL 90 100 110 120 130 140 90 100 110 120 130 140 pF1KE9 YNHGIGTLSSPLYIAWAGHLEAQGELQHASAVLQRGIQNQAEPREFLQQQYRLFQTRLTE .:.:::. . .::.:: . ::. ....:.:..:.:::..::: : ::.:.: ::.:... NP_001 HNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARVSR 150 160 170 180 190 200 150 160 170 180 190 200 pF1KE9 THLPAQARTSEPLHNVQVLNQMITSKSNPGNNMACI-SKNQGSELSGVISSACDKESNME : : . : .:... . ..:. .: . ::.. . . .: . .. . NP_001 QTLLALEKEEEE----EVFESSVPQRST----LAELKSKGKKTARAPIIRVGGALKAPSQ 210 220 230 240 250 210 220 230 240 250 260 pF1KE9 RRVITISKSEYSVHSSLASKVDVEQVVMYCKEKLIRGESEFSFEELRAQKYNQRRKHEQW : . .. . . . :.. : . .. .: : :: .. . : NP_001 NRGL---QNPFPQQMQNNSRITVFD----------ENADEASTAEL------SKPTVQPW 260 270 280 290 270 280 290 300 310 320 pF1KE9 VNEDRHYMKRKEANAFEEQLLKQKMDELHKKLHQVVETSHEDLPASQERSEVNPARMGPS . : : . : .. . . :. .. .: .:: : :. . : NP_001 IAPP---MPRAKENELQAGPWNTGRSLEHRPRGNT--ASLIAVPA------VLPS-FTPY 300 310 320 330 340 330 340 350 360 370 380 pF1KE9 V--GSQQELRAPCLPVTYQQTPVNMEKNPREAPPVVPPLANAISAALVSPATSQSIAPPV : .:: . .:: . .. .: .: :: . : .: .... . NP_001 VEETAQQPVMTPCKIEPSINHILSTRKPGKEEGD---PLQRVQSHQQASEEKKEKM---M 350 360 370 380 390 390 400 410 420 430 440 pF1KE9 PLKAQTVTD-SMFAVASKDAGCVNKSTHEFKPQSGAEIKEGCETHKVANTSSFHTTPNTS : . . . :. : : ..: : ::. . : : :. .. . . NP_001 YCKEKIYAGVGEFSFEEIRAEVFRK---KLKEQREAELLTSAE--KRAEMQKQIEEMEKK 400 410 420 430 440 450 450 460 470 480 490 500 pF1KE9 LGMVQATPSKV---QPSPTVHTKEALGFIMNMFQAPTLPDISDDKDEWQSLDQNEDAFEA : .:.: .. : :. :::. . . .. .: .. ... : : : :. NP_001 LKEIQTTQQERTGDQQEETMPTKETTKLQIAS-ESQKIPGMTLSSSVCQV---NCCARET 460 470 480 490 500 510 520 530 540 550 pF1KE9 QFQKNVRSSGAWGVNKIISSLSSAFHVFED---GNKENYGLP-QP-----KNKPTGARTF .. .:. : . .. : : .:.. ..:.: . : .: . .: .. NP_001 SLAENI-----WQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAVLKT 510 520 530 540 550 560 560 570 580 590 600 610 pF1KE9 GERSVSRLPSKPK--EEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDFTSAAQLASTPF .: .: .: .: : . .:. . :.: : :. :.:.. ::. ::...:::: NP_001 SESITSNEDVSPDVCDEFTGIEPLSEDAIITGFR-NVTICPNPEDTCDFARAARFVSTPF 570 580 590 600 610 620 620 630 640 650 660 670 pF1KE9 HKLPVESVHILEDKENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEKSPKQALSSHMY :. . :.: : : : .. : .: .. . .:. . .: NP_001 HE-----IMSLKD-------------LPSDPERLL-PEED---LDVKTSEDQQTACGTIY 630 640 650 660 680 690 700 710 720 pF1KE9 SASL-LRLSQPAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQA-EWMQMSSLG : .: .. .: . ... .... .. ..:..: ..: :: : ..... NP_001 SQTLSIKKLSP-----IIEDSREATHSSGFSGSSASVAST--SSIKCLQIPEKLELTNE- 670 680 690 700 710 730 740 750 760 770 780 pF1KE9 TVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEFQLGSK--LV : . : . .:: .. .::..: . .: .: . .: .. . :..::.. . NP_001 TSENP---TQSPWCSQYRRQLLKSLPELSASAELCIEDR-PMPKLEIEKEIELGNEDYCI 720 730 740 750 760 790 800 810 820 830 840 pF1KE9 YVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPSMQH ..:. : . . : . :.: . :.::.. ::.:::. .: :::. ...: NP_001 KREYLICED-YKLFWVAPR---NSA---ELTVIKVSSQPVPWDFYINLKLKERLNEDFDH 770 780 790 800 810 820 850 860 870 880 890 900 pF1KE9 MFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQ : : . .:.: .. ..: . .. .: ... . . . ... . . .: ..:. NP_001 ----FCSCYQYQDGCIV---WHQYINCFTLQDLLQHS--EYITHEITVLIIYNLLTIVEM 830 840 850 860 870 910 920 930 940 950 960 pF1KE9 VHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCE .: ::.:::..: .:: : . . : . . .: ..:.. :.:... . .:: NP_001 LHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRV--QLDVFT---- 880 890 900 910 920 970 980 990 1000 1010 1020 pF1KE9 TSGFQCVEML------SNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFRR :::. :..: .: ::.: ::.: .. .:: ...: .:. : . . NP_001 LSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISE 930 940 950 960 970 980 1030 1040 1050 1060 1070 pF1KE9 LPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQ---QHYTNKIRALRNRLIVLLL : ..::.:: .:: : . : : ... ::. : . :: NP_001 LKDGELWNKFFVRILNANDEATVSVLGELAAEMNGVFDTTFQSHLNKALWKVGKLTSPGA 990 1000 1010 1020 1030 1040 1080 pF1KE9 ECKRSRK NP_001 LLFQ 1050 1085 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 19:42:27 2016 done: Mon Nov 7 19:42:28 2016 Total Scan time: 11.030 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]