FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9668, 1362 aa 1>>>pF1KE9668 1362 - 1362 aa - 1362 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 17.2853+/-0.00132; mu= -27.7941+/- 0.080 mean_var=836.3888+/-171.581, 0's: 0 Z-trim(118.1): 145 B-trim: 198 in 2/51 Lambda= 0.044348 statistics sampled from 18800 (18939) to 18800 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.799), E-opt: 0.2 (0.582), width: 16 Scan time: 7.440 The best scores are: opt bits E(32554) CCDS12328.1 BRD4 gene_id:23476|Hs108|chr19 (1362) 9465 621.8 4e-177 CCDS46004.1 BRD4 gene_id:23476|Hs108|chr19 ( 722) 4847 326.1 2.1e-88 CCDS82307.1 BRD4 gene_id:23476|Hs108|chr19 ( 794) 4848 326.2 2.2e-88 CCDS6980.1 BRD3 gene_id:8019|Hs108|chr9 ( 726) 1747 127.8 1.1e-28 CCDS56421.1 BRD2 gene_id:6046|Hs108|chr6 ( 754) 1101 86.5 3.1e-16 CCDS4762.1 BRD2 gene_id:6046|Hs108|chr6 ( 801) 1101 86.5 3.3e-16 CCDS56420.1 BRD2 gene_id:6046|Hs108|chr6 ( 836) 1101 86.5 3.4e-16 CCDS55616.1 BRDT gene_id:676|Hs108|chr1 ( 874) 961 77.6 1.7e-13 CCDS55615.1 BRDT gene_id:676|Hs108|chr1 ( 901) 961 77.6 1.8e-13 CCDS735.1 BRDT gene_id:676|Hs108|chr1 ( 947) 961 77.6 1.8e-13 CCDS72820.1 BRDT gene_id:676|Hs108|chr1 ( 951) 961 77.6 1.8e-13 >>CCDS12328.1 BRD4 gene_id:23476|Hs108|chr19 (1362 aa) initn: 9465 init1: 9465 opt: 9465 Z-score: 3293.5 bits: 621.8 E(32554): 4e-177 Smith-Waterman score: 9465; 100.0% identity (100.0% similar) in 1362 aa overlap (1-1362:1-1362) 10 20 30 40 50 60 pF1KE9 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE9 APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE9 KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE9 SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE9 PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE9 MAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 MAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE9 PPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 PPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLP 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE9 QPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 QPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE9 PQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 PQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPP 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE9 PPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 PPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPP 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE9 HPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 HPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLT 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE9 HQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 HQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESI 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE9 KAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 KAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMG 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE9 SWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 SWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERM 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE9 RSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 RSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSM 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 pF1KE9 LDQQRELARKREQERRRREAMAATIDMNFQSDLLSIFEENLF :::::::::::::::::::::::::::::::::::::::::: CCDS12 LDQQRELARKREQERRRREAMAATIDMNFQSDLLSIFEENLF 1330 1340 1350 1360 >>CCDS46004.1 BRD4 gene_id:23476|Hs108|chr19 (722 aa) initn: 4847 init1: 4847 opt: 4847 Z-score: 1700.5 bits: 326.1 E(32554): 2.1e-88 Smith-Waterman score: 4847; 100.0% identity (100.0% similar) in 719 aa overlap (1-719:1-719) 10 20 30 40 50 60 pF1KE9 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE9 APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE9 KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE9 SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE9 PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE9 MAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPP CCDS46 PA >>CCDS82307.1 BRD4 gene_id:23476|Hs108|chr19 (794 aa) initn: 4847 init1: 4847 opt: 4848 Z-score: 1700.3 bits: 326.2 E(32554): 2.2e-88 Smith-Waterman score: 4848; 97.7% identity (98.1% similar) in 741 aa overlap (1-741:1-738) 10 20 30 40 50 60 pF1KE9 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE9 APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE9 KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE9 SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE9 PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE9 MAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPP . : :: . .: : CCDS82 FCT-SGDFVSPG--PSPYHSHVQCGRFREMLRWFLVDVEQTAAGQPHRQSAAGPAITWAP 730 740 750 760 770 >>CCDS6980.1 BRD3 gene_id:8019|Hs108|chr9 (726 aa) initn: 2726 init1: 939 opt: 1747 Z-score: 628.5 bits: 127.8 E(32554): 1.1e-28 Smith-Waterman score: 2537; 58.0% identity (74.8% similar) in 731 aa overlap (26-733:1-701) 10 20 30 40 50 pF1KE9 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQ-PANAASTNPPPPETSNPNKPKRQ :::. . : ::. . .::::::.:::.:: :. CCDS69 MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRK 10 20 30 60 70 80 90 100 110 pF1KE9 TNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYY ::::::. ::.:::::::::::: :::::.:::::::.::::.:::::::::::::::: CCDS69 TNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYY 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE9 WNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGR :.:.::.:::::::::::::::: :::::::.::::.::::. ..: ::.:.. ::. CCDS69 WSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGK 100 110 120 130 140 150 180 190 200 210 220 230 pF1KE9 GRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVM :: . .:. . :.. : ....: : : : :: :. :: .:. ::: CCDS69 GR-KPAAGAQSAGTQQVAAVSSVS--PATPF-QSVPPTVSQTP---------VIAATPVP 160 170 180 190 200 240 250 260 270 280 290 pF1KE9 TVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTT :.. : :::: ::: :: : :.. :: :: ::::::::::::::: CCDS69 TITANV---TSVPVPPAAAPPP-PATPIV----PVVPPTP-PVVKKKGVKRKADTTTPTT 210 220 230 240 250 300 310 320 330 340 350 pF1KE9 ID-PIHEPPSLPP--EPKTTKLGQRRESS-RPVKPPKKDVPDSQQHPAPEKSSKVSEQLK . : :: .:: .:. ::::. ::.::::::. :.. :..:.::.:. CCDS69 SAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLR 260 270 280 290 300 310 360 370 380 390 400 410 pF1KE9 CCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDA :..::.::..:::::::::::::::.::: :::: ::::::::.::.: :...::: :: CCDS69 YCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDA 320 330 340 350 360 370 420 430 440 450 460 470 pF1KE9 QEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPP : :.:::::::::::::::::::::::::::::::::::::::::: : .::.: CCDS69 QGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEP------VEAPALPA 380 390 400 410 420 480 490 500 510 520 530 pF1KE9 PTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNK :. .. .. .: :. :.:::...::::::: ::::::::::::::::::::: :: CCDS69 PAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNK 430 440 450 460 470 480 540 550 560 570 580 pF1KE9 PKKK----EKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKT---KKNNSSNSNVSKKEP :::: ::.::.: :::.:.:..:. ....::: :: : :: ....: . CCDS69 PKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKANSTTTAG 490 500 510 520 530 540 590 600 610 620 630 640 pF1KE9 APMKS---KPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLK .:. . .:.::::.. ::::.::::::::::.::::::::::::::::::::. CCDS69 RQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLR 550 560 570 580 590 600 650 660 670 680 690 pF1KE9 NSNPDEIEIDFETLKPSTLRELERYVTSCLRKK-RKP-------QAEKVDVIAGSSKMKG .:::::::::::::::.::::::::: :::.:: ::: :: : .. : : CCDS69 DSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEELAQEKKKE 610 620 630 640 650 660 700 710 720 730 740 750 pF1KE9 FSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQP . . .. :.. ::: . . . : : .: :.: CCDS69 LEKRLQDVSGQLSSSKKPARKEK--PGSAPSGGPSRLSSSSSSESGSSSSSGSSSDSSDS 670 680 690 700 710 720 760 770 780 790 800 810 pF1KE9 PPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVF CCDS69 E >>CCDS56421.1 BRD2 gene_id:6046|Hs108|chr6 (754 aa) initn: 2201 init1: 898 opt: 1101 Z-score: 404.9 bits: 86.5 E(32554): 3.1e-16 Smith-Waterman score: 2442; 56.2% identity (73.9% similar) in 729 aa overlap (44-724:13-708) 20 30 40 50 60 70 pF1KE9 LPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQTNQLQYLLRVVLKT ::::::.:::.:: : ::::::: .::.:. CCDS56 MASVPALQLTPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKA 10 20 30 40 80 90 100 110 120 130 pF1KE9 LWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMF ::::::::::.::::::::.::::.:::: ::::::::.:::::::: :.::.::::::: CCDS56 LWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMF 50 60 70 80 90 100 140 150 160 170 180 190 pF1KE9 TNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRGRGRKETGTAKPGV ::::::::: :::::::..:::.::::. .: :: :.... :. . . .. . .: CCDS56 TNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSV 110 120 130 140 150 160 200 210 220 230 240 250 pF1KE9 STVPNTTQASTPPQTQ--TPQPN-PPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTP ... .. .:. .: :: :. : : ::: ....:.. . :.. CCDS56 TSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPS-------VISSPLL-----KSLHSA 170 180 190 200 210 260 270 280 290 300 pF1KE9 -PPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPIHEP--P ::. ::: ::. :::::::::::::: : : : CCDS56 GPPLLAVTAAPPA-----------------QPLAKKKGVKRKADTTTPTPT-AILAPGSP 220 230 240 250 310 320 330 340 350 360 pF1KE9 SLPP---EPKTTKLG-QRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGILKE . :: :::...: .::::.::.:::.::.:::::. :..:.::::: :.::::: CCDS56 ASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKE 260 270 280 290 300 310 370 380 390 400 410 420 pF1KE9 MFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVR ...:::::::::::::::. ::::::: ::::::::.::.: :.: :.:::::::.:::: CCDS56 LLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVR 320 330 340 350 360 370 430 440 450 460 470 480 pF1KE9 LMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPP-TKVVAP ::::::::::::::.:::::::::::::.:.::::::: :: : :.:: .: . CCDS56 LMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSE 380 390 400 410 420 430 490 500 510 520 530 pF1KE9 PSSSDSSSDSSSDSD------------SSTDDSEEERAQRLAELQEQLKAVHEQLAALSQ :: .:::.:::. . : ..:::::::.:::::::::.::::::::::: CCDS56 SSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQ 440 450 460 470 480 490 540 550 560 570 580 pF1KE9 PQQNKPKKKEKDKKEKKK----EKHKRKEEVEENKKS-KAKEPP-PKKTKKNNSSNSNVS .:::.: ..:::::: :::. . ..:. :. .: .:: :::.:: ..:... . CCDS56 GPISKPKRK-REKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSA 500 510 520 530 540 550 590 600 610 620 pF1KE9 KKEPA---P------------MKSKPP--PT-YESEEEDKCKPMSYEEKRQLSLDINKLP :. : :. :: :: :.::::.. .::::.::::::::::::: CCDS56 ALGPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLP 560 570 580 590 600 610 630 640 650 660 670 680 pF1KE9 GEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKK-RKPQAEK ::::::::::::.:::::..:::.::::::::::::::::::::: :::::: ::: . : CCDS56 GEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIK 620 630 640 650 660 670 690 700 710 720 730 740 pF1KE9 VDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQ : :..: . .. : .. .. ... . :. :: CCDS56 KPV--GKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSA 680 690 700 710 720 750 760 770 780 790 800 pF1KE9 MQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQV CCDS56 SSSSSDSSSSSSSSSSSDTSDSDSG 730 740 750 >>CCDS4762.1 BRD2 gene_id:6046|Hs108|chr6 (801 aa) initn: 2201 init1: 898 opt: 1101 Z-score: 404.6 bits: 86.5 E(32554): 3.3e-16 Smith-Waterman score: 2486; 54.8% identity (73.1% similar) in 767 aa overlap (5-724:27-755) 10 20 30 pF1KE9 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPA ..:: :.:. .. .:.:. :... : : :: CCDS47 MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPAL-QLTPA 10 20 30 40 50 40 50 60 70 80 90 pF1KE9 NAASTNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYY ::::::.:::.:: : ::::::: .::.:.::::::::::.::::::::.::::. CCDS47 -----NPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYH 60 70 80 90 100 110 100 110 120 130 140 150 pF1KE9 KIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFL :::: ::::::::.:::::::: :.::.:::::::::::::::: :::::::..:::.:: CCDS47 KIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFL 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE9 QKINELPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQ--TPQPN-P ::. .: :: :.... :. . . .. . .:... .. .:. .: :: :. : CCDS47 QKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIP 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE9 PPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPII : ::: ....:.. . .. ::. ::: CCDS47 TTVLNIPHPS-------VISSPLLKSLH----SAGPPLLAVTAAPPA------------- 240 250 260 270 280 290 300 310 320 pF1KE9 AATPQPVKTKKGVKRKADTTTPTTIDPIHEP--PSLPP---EPKTTKLG-QRRESSRPVK ::. :::::::::::::: : : :. :: :::...: .::::.::.: CCDS47 ----QPLAKKKGVKRKADTTTPTPT-AILAPGSPASPPGSLEPKAARLPPMRRESGRPIK 280 290 300 310 320 330 340 350 360 370 380 pF1KE9 PPKKDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHD ::.::.:::::. :..:.::::: :.:::::...:::::::::::::::. :::::: CCDS47 PPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHD 330 340 350 360 370 380 390 400 410 420 430 440 pF1KE9 YCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDV : ::::::::.::.: :.: :.:::::::.::::::::::::::::::.::::::::::: CCDS47 YHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDV 390 400 410 420 430 440 450 460 470 480 490 pF1KE9 FEMRFAKMPDEPEEPVVAVSSPAVPPP-TKVVAPPSSSDSSSDSSSDSD----------- ::.:.::::::: :: : :.:: .: . :: .:::.:::. . CCDS47 FEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEE 450 460 470 480 490 500 500 510 520 530 540 550 pF1KE9 -SSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKK----EKHK : ..:::::::.:::::::::.::::::::::: .:::.: ..:::::: :::. CCDS47 ESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRK-REKKEKKKKRKAEKHR 510 520 530 540 550 560 560 570 580 590 pF1KE9 RKEEVEENKKS-KAKEPP-PKKTKKNNSSNSNVSKKEPA---P------------MKSKP . ..:. :. .: .:: :::.:: ..:... . :. : :. : CCDS47 GRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAP 570 580 590 600 610 620 600 610 620 630 640 650 pF1KE9 P--PT-YESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEI : :: :.::::.. .::::.:::::::::::::::::::::::::.:::::..:::.:: CCDS47 PALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEI 630 640 650 660 670 680 660 670 680 690 700 710 pF1KE9 EIDFETLKPSTLRELERYVTSCLRKK-RKPQAEKVDVIAGSSKMKGFSSSESESSSESSS ::::::::::::::::::: :::::: ::: . : : :..: . .. : .. .. CCDS47 EIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPV--GKTKEELALEKKRELEKRLQD 690 700 710 720 730 740 720 730 740 750 760 770 pF1KE9 SDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQ ... . :. :: CCDS47 VSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG 750 760 770 780 790 800 >>CCDS56420.1 BRD2 gene_id:6046|Hs108|chr6 (836 aa) initn: 2267 init1: 898 opt: 1101 Z-score: 404.3 bits: 86.5 E(32554): 3.4e-16 Smith-Waterman score: 2420; 52.4% identity (70.1% similar) in 802 aa overlap (5-724:27-790) 10 20 30 pF1KE9 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPA ..:: :.:. .. .:.:. :... : : :: CCDS56 MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPAL-QLTPA 10 20 30 40 50 40 50 60 70 80 90 pF1KE9 NAASTNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYY ::::::.:::.:: : ::::::: .::.:.::::::::::.::::::::.::::. CCDS56 -----NPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYH 60 70 80 90 100 110 100 110 120 130 140 150 pF1KE9 KIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFL :::: ::::::::.:::::::: :.::.:::::::::::::::: :::::::..:::.:: CCDS56 KIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFL 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE9 QKINELPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQ--TPQPN-P ::. .: :: :.... :. . . .. . .:... .. .:. .: :: :. : CCDS56 QKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIP 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE9 PPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPII : ::: ....:.. . .. ::. ::: CCDS56 TTVLNIPHPS-------VISSPLLKSLH----SAGPPLLAVTAAPPA------------- 240 250 260 270 280 290 300 310 320 pF1KE9 AATPQPVKTKKGVKRKADTTTPTTIDPIHEP--PSLPP---EPKTTKLG-QRRESSRPVK ::. :::::::::::::: : : :. :: :::...: .::::.::.: CCDS56 ----QPLAKKKGVKRKADTTTPTPT-AILAPGSPASPPGSLEPKAARLPPMRRESGRPIK 280 290 300 310 320 330 340 350 360 370 380 pF1KE9 PPKKDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHD ::.::.:::::. :..:.::::: :.:::::...:::::::::::::::. :::::: CCDS56 PPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHD 330 340 350 360 370 380 390 400 410 420 430 440 pF1KE9 YCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDV : ::::::::.::.: :.: :.:::::::.::::::::::::::::::.::::::::::: CCDS56 YHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDV 390 400 410 420 430 440 450 460 470 480 490 pF1KE9 FEMRFAKMPDEPEEPVVAVSSPAVPPP-TKVVAPPSSSDSSSDSSSDSD----------- ::.:.::::::: :: : :.:: .: . :: .:::.:::. . CCDS56 FEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEE 450 460 470 480 490 500 500 510 520 530 540 550 pF1KE9 -SSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKK----EKHK : ..:::::::.:::::::::.::::::::::: .:::.: ..:::::: :::. CCDS56 ESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRK-REKKEKKKKRKAEKHR 510 520 530 540 550 560 560 570 580 pF1KE9 RKEEVEENKKS-KAKEPP-PKKTKKNNSSNSNVSKKEPA--------------------- . ..:. :. .: .:: :::.:: ..:... . :. CCDS56 GRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLQAGVQWRDL 570 580 590 600 610 620 590 600 610 pF1KE9 -----PM------------------------KSKPP--PT-YESEEEDKCKPMSYEEKRQ :. :. :: :: :.::::.. .::::.:::: CCDS56 GLLQPPLLGFKRFSCLSLPSSQDYRLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQ 630 640 650 660 670 680 620 630 640 650 660 670 pF1KE9 LSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRK :::::::::::::::::::::.:::::..:::.::::::::::::::::::::: ::::: CCDS56 LSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRK 690 700 710 720 730 740 680 690 700 710 720 730 pF1KE9 K-RKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQK : ::: . : : :..: . .. : .. .. ... . :. :: CCDS56 KPRKPYTIKKPV--GKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQ 750 760 770 780 790 800 740 750 760 770 780 790 pF1KE9 KHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSS CCDS56 QVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG 810 820 830 >>CCDS55616.1 BRDT gene_id:676|Hs108|chr1 (874 aa) initn: 1793 init1: 704 opt: 961 Z-score: 355.6 bits: 77.6 E(32554): 1.7e-13 Smith-Waterman score: 1628; 46.0% identity (65.5% similar) in 687 aa overlap (105-737:1-615) 80 90 100 110 120 130 pF1KE9 WKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFT ::..::::::::.:: .:.:::.::::::. CCDS55 MDLNTIKKRLENKYYAKASECIEDFNTMFS 10 20 30 140 150 160 170 180 190 pF1KE9 NCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRGRGRKETGTAKPGVS :::.::::::::::::.::::::.::....: :: ..: .: : : :. CCDS55 NCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEE---QVVGVKER---------IKKGT- 40 50 60 70 200 210 220 230 240 250 pF1KE9 TVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVP : : .: . :..: .. : . .: : . CCDS55 -----------------QQNIAVSSAKEKSSPSATEKVFKQQEIPSVFPKTSI------- 80 90 100 110 260 270 280 290 300 310 pF1KE9 PQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPK .: : . . ... ... ::::::::::::.: . .. . : CCDS55 ---------SPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPAT-SAVKASSEFSP--- 120 130 140 150 160 320 330 340 350 360 370 pF1KE9 TTKLGQRRESSRPVKP--PKKDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAY . .. . :.: ::. .:::::. :. ::.:::. :: :::::.:::: .: CCDS55 --TFTEKSVALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSY 170 180 190 200 210 380 390 400 410 420 430 pF1KE9 AWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKY :::::.::::.:::::.: :..:.:::..::: :.. .::.:: .:.::::::: ::::: CCDS55 AWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKY 220 230 240 250 260 270 440 450 460 470 480 490 pF1KE9 NPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDS ::::::::.::: :::::: .:.:.: :: : : : : .. .. ...... CCDS55 NPPDHEVVTMARMLQDVFETHFSKIPIEPVE-----SMPLCYIKTDITET-TGRENTNEA 280 290 300 310 320 330 500 510 520 530 540 550 pF1KE9 SSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQ-PQQNKPKKKEKDKKEKKKEKH ::...:: ::::.::..:::.:::::::::.:: .::: : .. :::::.:::::::: CCDS55 SSEGNSS-DDSEDERVKRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKV 340 350 360 370 380 390 560 570 580 590 600 610 pF1KE9 KRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEEDKCKPMS . ..: . .: . .:.:.:. .. :.. .:: :.::. :::. CCDS55 NNSNE--NPRKMCEQMRLKEKSKRNQPKKR---KQQFIGLKS--------EDEDNAKPMN 400 410 420 430 620 630 640 650 660 670 pF1KE9 YEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYV :.:::::::.::::::.::::::::::::::::.::::::::::::::: :::::::.:: CCDS55 YDEKRQLSLNINKLPGDKLGRVVHIIQSREPSLSNSNPDEIEIDFETLKASTLRELEKYV 440 450 460 470 480 490 680 pF1KE9 TSCLRKKR-KPQAEKV--------------------DV---------------------I ..::::. :: :.:. :: . CCDS55 SACLRKRPLKPPAKKIMMSKEELHSQKKQELEKRLLDVNNQLNSRKRQTKSDKTQPSKAV 500 510 520 530 540 550 690 700 710 720 730 740 pF1KE9 AGSSKMK-----GFSSSESESSSES-SSSDSEDSETEMAPK---SKKKGHPGREQKKHHH . :... . ::::::::: . ::::: :::.:: :: : . :..:. : CCDS55 ENVSRLSESSSSSSSSSESESSSSDLSSSDSSDSESEMFPKFTEVKPNDSPSKENVKKMK 560 570 580 590 600 610 750 760 770 780 790 800 pF1KE9 HHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPF CCDS55 NECIPPEGRTGVTQIGYCVQDTTSANTTLVHQTTPSHVMPPNHHQLAFNYQELEHLQTVK 620 630 640 650 660 670 >>CCDS55615.1 BRDT gene_id:676|Hs108|chr1 (901 aa) initn: 1850 init1: 704 opt: 961 Z-score: 355.5 bits: 77.6 E(32554): 1.8e-13 Smith-Waterman score: 1599; 43.3% identity (61.2% similar) in 757 aa overlap (35-737:4-642) 10 20 30 40 50 60 pF1KE9 SGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQTNQLQ :. .: .:::::: : .: : ::::: CCDS55 MSLPSRQTAIIVNPPPPEYINTKKNGRLTNQLQ 10 20 30 70 80 90 100 110 120 pF1KE9 YLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQE :: .:::: ::::.:.::::.:::::::.:: CCDS55 YLQKVVLKDLWKHSFSWPFQRPVDAVKLQLP----------------------------- 40 50 60 130 140 150 160 170 180 pF1KE9 CIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRGRGRK :::::::::.::::::.::....: :: ..: .: : CCDS55 -----------------PGDDIVLMAQALEKLFMQKLSQMPQEE---QVVGVKER----- 70 80 90 190 200 210 220 230 240 pF1KE9 ETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPP : :. : : .: . :..: .. : . .: : CCDS55 ----IKKGT------------------QQNIAVSSAKEKSSPSATEKVFKQQEIPSVFPK 100 110 120 130 250 260 270 280 290 300 pF1KE9 QPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPIH . .: : . . ... ... ::::::::::::.: . .. CCDS55 TSI----------------SPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPAT-SAVK 140 150 160 170 180 310 320 330 340 350 360 pF1KE9 EPPSLPPEPKTTKLGQRRESSRPVKP--PKKDVPDSQQHPAPEKSSKVSEQLKCCSGILK . : . .. . :.: ::. .:::::. :. ::.:::. :: ::: CCDS55 ASSEFSPT-----FTEKSVALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILK 190 200 210 220 230 370 380 390 400 410 420 pF1KE9 EMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADV ::.:::: .::::::.::::.:::::.: :..:.:::..::: :.. .::.:: .:.::: CCDS55 EMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADV 240 250 260 270 280 290 430 440 450 460 470 480 pF1KE9 RLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAP :::: :::::::::::::.::: :::::: .:.:.: :: : : : : .. CCDS55 RLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIEPVE-----SMPLCYIKTDITET 300 310 320 330 340 350 490 500 510 520 530 540 pF1KE9 PSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQ-PQQNKPKKKEK .. ......::...:: ::::.::..:::.:::::::::.:: .::: : .. ::::: CCDS55 -TGRENTNEASSEGNSS-DDSEDERVKRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEK 360 370 380 390 400 550 560 570 580 590 600 pF1KE9 DKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYES .:::::::: . ..: . .: . .:.:.:. .. :.. .:: CCDS55 SKKEKKKEKVNNSNE--NPRKMCEQMRLKEKSKRNQPKK---RKQQFIGLKS-------- 410 420 430 440 450 610 620 630 640 650 660 pF1KE9 EEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKP :.::. :::.:.:::::::.::::::.::::::::::::::::.::::::::::::::: CCDS55 EDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSREPSLSNSNPDEIEIDFETLKA 460 470 480 490 500 510 670 680 pF1KE9 STLRELERYVTSCLRKKR-KPQAEKV--------------------DV------------ :::::::.::..::::. :: :.:. :: CCDS55 STLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQELEKRLLDVNNQLNSRKRQTK 520 530 540 550 560 570 690 700 710 720 730 pF1KE9 ---------IAGSSKMK-----GFSSSESESSSES-SSSDSEDSETEMAPK---SKKKGH . . :... . ::::::::: . ::::: :::.:: :: : . CCDS55 SDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSSDSSDSESEMFPKFTEVKPNDS 580 590 600 610 620 630 740 750 760 770 780 790 pF1KE9 PGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAA :..:. : CCDS55 PSKENVKKMKNECIPPEGRTGVTQIGYCVQDTTSANTTLVHQTTPSHVMPPNHHQLAFNY 640 650 660 670 680 690 >>CCDS735.1 BRDT gene_id:676|Hs108|chr1 (947 aa) initn: 2120 init1: 704 opt: 961 Z-score: 355.2 bits: 77.6 E(32554): 1.8e-13 Smith-Waterman score: 1955; 48.0% identity (67.0% similar) in 757 aa overlap (35-737:4-688) 10 20 30 40 50 60 pF1KE9 SGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQTNQLQ :. .: .:::::: : .: : ::::: CCDS73 MSLPSRQTAIIVNPPPPEYINTKKNGRLTNQLQ 10 20 30 70 80 90 100 110 120 pF1KE9 YLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQE :: .:::: ::::.:.::::.:::::::.::::: :::.:::..::::::::.:: .:.: CCDS73 YLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASE 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE9 CIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRGRGRK ::.::::::.:::.::::::::::::.::::::.::....: :: ..: .: : CCDS73 CIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEE---QVVGVKER----- 100 110 120 130 140 190 200 210 220 230 240 pF1KE9 ETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPP : :. : : .: . :..: .. : . .: : CCDS73 ----IKKGT------------------QQNIAVSSAKEKSSPSATEKVFKQQEIPSVFPK 150 160 170 180 250 260 270 280 290 300 pF1KE9 QPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPIH . .: : . . ... ... ::::::::::::.: . .. CCDS73 TSI----------------SPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPAT-SAVK 190 200 210 220 310 320 330 340 350 360 pF1KE9 EPPSLPPEPKTTKLGQRRESSRPVKP--PKKDVPDSQQHPAPEKSSKVSEQLKCCSGILK . : . .. . :.: ::. .:::::. :. ::.:::. :: ::: CCDS73 ASSEFSPT-----FTEKSVALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILK 230 240 250 260 270 280 370 380 390 400 410 420 pF1KE9 EMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADV ::.:::: .::::::.::::.:::::.: :..:.:::..::: :.. .::.:: .:.::: CCDS73 EMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADV 290 300 310 320 330 340 430 440 450 460 470 480 pF1KE9 RLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAP :::: :::::::::::::.::: :::::: .:.:.: :: : : : : .. CCDS73 RLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIEPVE-----SMPLCYIKTDITET 350 360 370 380 390 490 500 510 520 530 540 pF1KE9 PSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQ-PQQNKPKKKEK .. ......::...:: ::::.::..:::.:::::::::.:: .::: : .. ::::: CCDS73 -TGRENTNEASSEGNSS-DDSEDERVKRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEK 400 410 420 430 440 450 550 560 570 580 590 600 pF1KE9 DKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYES .:::::::: . ..: . .: . .:.:.:. .. :.. .:: CCDS73 SKKEKKKEKVNNSNE--NPRKMCEQMRLKEKSKRNQPKK---RKQQFIGLKS-------- 460 470 480 490 500 610 620 630 640 650 660 pF1KE9 EEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKP :.::. :::.:.:::::::.::::::.::::::::::::::::.::::::::::::::: CCDS73 EDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSREPSLSNSNPDEIEIDFETLKA 510 520 530 540 550 560 670 680 pF1KE9 STLRELERYVTSCLRKKR-KPQAEKV--------------------DV------------ :::::::.::..::::. :: :.:. :: CCDS73 STLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQELEKRLLDVNNQLNSRKRQTK 570 580 590 600 610 620 690 700 710 720 730 pF1KE9 ---------IAGSSKMK-----GFSSSESESSSES-SSSDSEDSETEMAPK---SKKKGH . . :... . ::::::::: . ::::: :::.:: :: : . CCDS73 SDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSSDSSDSESEMFPKFTEVKPNDS 630 640 650 660 670 680 740 750 760 770 780 790 pF1KE9 PGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAA :..:. : CCDS73 PSKENVKKMKNECIPPEGRTGVTQIGYCVQDTTSANTTLVHQTTPSHVMPPNHHQLAFNY 690 700 710 720 730 740 1362 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Dec 21 11:12:58 2016 done: Wed Dec 21 11:12:59 2016 Total Scan time: 7.440 Total Display time: 0.390 Function used was FASTA [36.3.4 Apr, 2011]