Result of FASTA (omim) for
pF1KE9669
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE9669, 2997 aa
1>>>pF1KE9669 2997 - 2997 aa - 2997 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 15.9658+/-0.000573; mu= -23.5369+/- 0.036
mean_var=681.4704+/-138.538, 0's: 0 Z-trim(121.2): 266 B-trim: 33 in 1/59
Lambda= 0.049130
statistics sampled from 37139 (37415) to 37139 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.729), E-opt: 0.2 (0.439), width: 16
Scan time: 27.110
The best scores are: opt bits E(85289)
NP_060250 (OMIM: 189960,214800,608892,612370) chro (2997) 20314 1457.6 0
XP_016869102 (OMIM: 189960,214800,608892,612370) P (2996) 20297 1456.4 0
XP_011515857 (OMIM: 189960,214800,608892,612370) P (3026) 11978 866.7 0
XP_011515856 (OMIM: 189960,214800,608892,612370) P (3027) 11978 866.7 0
XP_016869101 (OMIM: 189960,214800,608892,612370) P (3027) 11978 866.7 0
XP_011515855 (OMIM: 189960,214800,608892,612370) P (3027) 11978 866.7 0
XP_011515862 (OMIM: 189960,214800,608892,612370) P (1621) 11138 807.0 0
XP_016879216 (OMIM: 616936) PREDICTED: chromodomai (2375) 6651 489.1 3.6e-136
XP_016879214 (OMIM: 616936) PREDICTED: chromodomai (2431) 6651 489.1 3.7e-136
XP_016879211 (OMIM: 616936) PREDICTED: chromodomai (2882) 6651 489.1 4.2e-136
NP_079410 (OMIM: 616936) chromodomain-helicase-DNA (2881) 6607 486.0 3.6e-135
XP_005256229 (OMIM: 616936) PREDICTED: chromodomai (2881) 6607 486.0 3.6e-135
XP_016879212 (OMIM: 616936) PREDICTED: chromodomai (2881) 6607 486.0 3.6e-135
NP_001164100 (OMIM: 610528,615032) chromodomain-he (2581) 6154 453.9 1.5e-125
NP_065971 (OMIM: 610528,615032) chromodomain-helic (2302) 6109 450.7 1.3e-124
XP_016883593 (OMIM: 616114) PREDICTED: chromodomai (2378) 5891 435.2 5.9e-120
XP_016883591 (OMIM: 616114) PREDICTED: chromodomai (2424) 5891 435.2 6e-120
XP_005260630 (OMIM: 616114) PREDICTED: chromodomai (2693) 5891 435.3 6.5e-120
XP_016883589 (OMIM: 616114) PREDICTED: chromodomai (2693) 5891 435.3 6.5e-120
XP_011527382 (OMIM: 616114) PREDICTED: chromodomai (2713) 5891 435.3 6.6e-120
NP_115597 (OMIM: 616114) chromodomain-helicase-DNA (2715) 5891 435.3 6.6e-120
XP_016883588 (OMIM: 616114) PREDICTED: chromodomai (2716) 5891 435.3 6.6e-120
XP_005256233 (OMIM: 616936) PREDICTED: chromodomai (2391) 5851 432.4 4.2e-119
XP_016879215 (OMIM: 616936) PREDICTED: chromodomai (2424) 5851 432.4 4.3e-119
XP_016879213 (OMIM: 616936) PREDICTED: chromodomai (2447) 5851 432.4 4.3e-119
NP_001295248 (OMIM: 616936) chromodomain-helicase- (2897) 5851 432.4 4.9e-119
XP_016879210 (OMIM: 616936) PREDICTED: chromodomai (2897) 5851 432.4 4.9e-119
XP_006721344 (OMIM: 616936) PREDICTED: chromodomai (2898) 5851 432.4 4.9e-119
XP_005256225 (OMIM: 616936) PREDICTED: chromodomai (2898) 5851 432.4 4.9e-119
XP_016879209 (OMIM: 616936) PREDICTED: chromodomai (2898) 5851 432.4 4.9e-119
XP_011521649 (OMIM: 616936) PREDICTED: chromodomai (2898) 5851 432.4 4.9e-119
XP_006721346 (OMIM: 616936) PREDICTED: chromodomai (2898) 5851 432.4 4.9e-119
XP_016879208 (OMIM: 616936) PREDICTED: chromodomai (2898) 5851 432.4 4.9e-119
XP_005256226 (OMIM: 616936) PREDICTED: chromodomai (2898) 5851 432.4 4.9e-119
XP_016879207 (OMIM: 616936) PREDICTED: chromodomai (2898) 5851 432.4 4.9e-119
XP_016879217 (OMIM: 616936) PREDICTED: chromodomai (2237) 5659 418.7 5e-115
XP_016883592 (OMIM: 616114) PREDICTED: chromodomai (2381) 5431 402.6 3.9e-110
NP_001303619 (OMIM: 189960,214800,608892,612370) c ( 948) 4183 313.9 8e-84
XP_016883590 (OMIM: 616114) PREDICTED: chromodomai (2668) 3805 287.4 2.1e-75
XP_011527384 (OMIM: 616114) PREDICTED: chromodomai (2038) 3683 278.7 6.8e-73
XP_016874223 (OMIM: 603277,617159) PREDICTED: chro (1892) 1655 134.9 1.2e-29
XP_016874222 (OMIM: 603277,617159) PREDICTED: chro (1893) 1655 134.9 1.2e-29
XP_016874221 (OMIM: 603277,617159) PREDICTED: chro (1895) 1655 134.9 1.2e-29
XP_016874220 (OMIM: 603277,617159) PREDICTED: chro (1899) 1655 134.9 1.2e-29
XP_016874219 (OMIM: 603277,617159) PREDICTED: chro (1900) 1655 134.9 1.2e-29
XP_006719025 (OMIM: 603277,617159) PREDICTED: chro (1902) 1655 134.9 1.2e-29
XP_005253725 (OMIM: 603277,617159) PREDICTED: chro (1905) 1655 134.9 1.2e-29
NP_001284482 (OMIM: 603277,617159) chromodomain-he (1905) 1655 134.9 1.2e-29
XP_016874218 (OMIM: 603277,617159) PREDICTED: chro (1906) 1655 134.9 1.2e-29
XP_006719024 (OMIM: 603277,617159) PREDICTED: chro (1908) 1655 134.9 1.2e-29
>>NP_060250 (OMIM: 189960,214800,608892,612370) chromodo (2997 aa)
initn: 20314 init1: 20314 opt: 20314 Z-score: 7798.1 bits: 1457.6 E(85289): 0
Smith-Waterman score: 20314; 100.0% identity (100.0% similar) in 2997 aa overlap (1-2997:1-2997)
10 20 30 40 50 60
pF1KE9 MADPGMMSLFGEDGNIFSEGLEGLGECGYPENPVNPMGQQMPIDQGFASLQPSLHHPSTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MADPGMMSLFGEDGNIFSEGLEGLGECGYPENPVNPMGQQMPIDQGFASLQPSLHHPSTN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 QNQTKLTHFDHYNQYEQQKMHLMDQPNRMMSNTPGNGLASPHSQYHTPPVPQVPHGGSGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 QNQTKLTHFDHYNQYEQQKMHLMDQPNRMMSNTPGNGLASPHSQYHTPPVPQVPHGGSGG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 GQMGVYPGMQNERHGQSFVDSSSMWGPRAVQVPDQIRAPYQQQQPQPQPPQPAPSGPPAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GQMGVYPGMQNERHGQSFVDSSSMWGPRAVQVPDQIRAPYQQQQPQPQPPQPAPSGPPAQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 GHPQHMQQMGSYMARGDFSMQQHGQPQQRMSQFSQGQEGLNQGNPFIATSGPGHLSHVPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GHPQHMQQMGSYMARGDFSMQQHGQPQQRMSQFSQGQEGLNQGNPFIATSGPGHLSHVPQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 QSPSMAPSLRHSVQQFHHHPSTALHGESVAHSPRFSPNPPQQGAVRPQTLNFSSRSQTVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 QSPSMAPSLRHSVQQFHHHPSTALHGESVAHSPRFSPNPPQQGAVRPQTLNFSSRSQTVP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 SPTINNSGQYSRYPYSNLNQGLVNNTGMNQNLGLTNNTPMNQSVPRYPNAVGFPSNSGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SPTINNSGQYSRYPYSNLNQGLVNNTGMNQNLGLTNNTPMNQSVPRYPNAVGFPSNSGQG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 LMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNPAGTPPPQVRPGSAGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNPAGTPPPQVRPGSAGI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 PMEVGSYPNMPHPQPSHQPPGAMGIGQRNMGPRNMQQSRPFIGMSSAPRELTGHMRPNGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 PMEVGSYPNMPHPQPSHQPPGAMGIGQRNMGPRNMQQSRPFIGMSSAPRELTGHMRPNGC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 PGVGLGDPQAIQERLIPGQQHPGQQPSFQQLPTCPPLQPHPGLHHQSSPPHPHHQPWAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 PGVGLGDPQAIQERLIPGQQHPGQQPSFQQLPTCPPLQPHPGLHHQSSPPHPHHQPWAQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 HPSPQNTPQKVPVHQHSPSEPFLEKPVPDMTQVSGPNAQLVKSDDYLPSIEQQPQQKKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 HPSPQNTPQKVPVHQHSPSEPFLEKPVPDMTQVSGPNAQLVKSDDYLPSIEQQPQQKKKK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 KKNNHIVAEDPSKGFGKDDFPGGVDNQELNRNSLDGSQEEKKKKKRSKAKKDPKEPKEPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 KKNNHIVAEDPSKGFGKDDFPGGVDNQELNRNSLDGSQEEKKKKKRSKAKKDPKEPKEPK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 EKKEPKEPKTPKAPKIPKEPKEKKAKTATPKPKSSKKSSNKKPDSEASALKKKVNKGKTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EKKEPKEPKTPKAPKIPKEPKEKKAKTATPKPKSSKKSSNKKPDSEASALKKKVNKGKTE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 GSENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GSENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE9 DSPSNTSQSEQQESVDAEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 DSPSNTSQSEQQESVDAEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQW
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE9 ASIEDLEKDKRIQQKIKRFKAKQGQNKFLSEIEDELFNPDYVEVDRIMDFARSTDDRGEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ASIEDLEKDKRIQQKIKRFKAKQGQNKFLSEIEDELFNPDYVEVDRIMDFARSTDDRGEP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE9 VTHYLVKWCSLPYEDSTWERRQDIDQAKIEEFEKLMSREPETERVERPPADDWKKSESSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 VTHYLVKWCSLPYEDSTWERRQDIDQAKIEEFEKLMSREPETERVERPPADDWKKSESSR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE9 EYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE9 VIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 VIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAI
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE9 ITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNT
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE9 VEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 VEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAP
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE9 KEETIIEVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLING
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 KEETIIEVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLING
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE9 AEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 AEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLD
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE9 ILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADT
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE9 CIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 CIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQ
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE9 SMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITI
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE9 ESEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ESEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRK
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE9 QTRLYSAVKEDELMEFSDLESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGWGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 QTRLYSAVKEDELMEFSDLESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGWGR
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE9 WTDILSHGRYKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 WTDILSHGRYKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRALV
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE9 NHSGLSAPVPRGRKGKKVKAQSTQPVVQDADWLASCNPDALFQEDSYKKHLKHHCNKVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 NHSGLSAPVPRGRKGKKVKAQSTQPVVQDADWLASCNPDALFQEDSYKKHLKHHCNKVLL
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE9 RVRMLYYLRQEVIGDQADKILEGADSSEADVWIPEPFHAEVPADWWDKEADKSLLIGVFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 RVRMLYYLRQEVIGDQADKILEGADSSEADVWIPEPFHAEVPADWWDKEADKSLLIGVFK
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE9 HGYEKYNSMRADPALCFLERVGMPDAKAIAAEQRGTDMLADGGDGGEFDREDEDPEYKPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 HGYEKYNSMRADPALCFLERVGMPDAKAIAAEQRGTDMLADGGDGGEFDREDEDPEYKPT
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE9 RTPFKDEIDEFANSPSEDKEESMEIHATGKHSESNAELGQLYWPNTSTLTTRLRRLITAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 RTPFKDEIDEFANSPSEDKEESMEIHATGKHSESNAELGQLYWPNTSTLTTRLRRLITAY
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE9 QRSYKRQQMRQEALMKTDRRRRRPREEVRALEAEREAIISEKRQKWTRREEADFYRVVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 QRSYKRQQMRQEALMKTDRRRRRPREEVRALEAEREAIISEKRQKWTRREEADFYRVVST
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE9 FGVIFDPVKQQFDWNQFRAFARLDKKSDESLEKYFSCFVAMCRRVCRMPVKPDDEPPDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 FGVIFDPVKQQFDWNQFRAFARLDKKSDESLEKYFSCFVAMCRRVCRMPVKPDDEPPDLS
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE9 SIIEPITEERASRTLYRIELLRKIREQVLHHPQLGERLKLCQPSLDLPEWWECGRHDRDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SIIEPITEERASRTLYRIELLRKIREQVLHHPQLGERLKLCQPSLDLPEWWECGRHDRDL
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE9 LVGAAKHGVSRTDYHILNDPELSFLDAHKNFAQNRGAGNTSSLNPLAVGFVQTPPVISSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LVGAAKHGVSRTDYHILNDPELSFLDAHKNFAQNRGAGNTSSLNPLAVGFVQTPPVISSA
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE9 HIQDERVLEQAEGKVEEPENPAAKEKCEGKEEEEETDGSGKESKQECEAEASSVKNELKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 HIQDERVLEQAEGKVEEPENPAAKEKCEGKEEEEETDGSGKESKQECEAEASSVKNELKG
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KE9 VEVGADTGSKSISEKGSEEDEEEKLEDDDKSEESSQPEAGAVSRGKNFDEESNASMSTAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 VEVGADTGSKSISEKGSEEDEEEKLEDDDKSEESSQPEAGAVSRGKNFDEESNASMSTAR
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KE9 DETRDGFYMEDGDPSVAQLLHERTFAFSFWPKDRVMINRLDNICEAVLKGKWPVNRRQMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 DETRDGFYMEDGDPSVAQLLHERTFAFSFWPKDRVMINRLDNICEAVLKGKWPVNRRQMF
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KE9 DFQGLIPGYTPTTVDSPLQKRSFAELSMVGQASISGSEDITTSPQLSKEDALNLSVPRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 DFQGLIPGYTPTTVDSPLQKRSFAELSMVGQASISGSEDITTSPQLSKEDALNLSVPRQR
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KE9 RRRRRKIEIEAERAAKRRNLMEMVAQLRESQVVSENGQEKVVDLSKASREATSSTSNFSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 RRRRRKIEIEAERAAKRRNLMEMVAQLRESQVVSENGQEKVVDLSKASREATSSTSNFSS
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KE9 LSSKFILPNVSTPVSDAFKTQMELLQAGLSRTPTRHLLNGSLVDGEPPMKRRRGRRKNVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LSSKFILPNVSTPVSDAFKTQMELLQAGLSRTPTRHLLNGSLVDGEPPMKRRRGRRKNVE
2470 2480 2490 2500 2510 2520
2530 2540 2550 2560 2570 2580
pF1KE9 GLDLLFMSHKRTSLSAEDAEVTKAFEEDIETPPTRNIPSPGQLDPDTRIPVINLEDGTRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GLDLLFMSHKRTSLSAEDAEVTKAFEEDIETPPTRNIPSPGQLDPDTRIPVINLEDGTRL
2530 2540 2550 2560 2570 2580
2590 2600 2610 2620 2630 2640
pF1KE9 VGEDAPKNKDLVEWLKLHPTYTVDMPSYVPKNADVLFSSFQKPKQKRHRCRNPNKLDINT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 VGEDAPKNKDLVEWLKLHPTYTVDMPSYVPKNADVLFSSFQKPKQKRHRCRNPNKLDINT
2590 2600 2610 2620 2630 2640
2650 2660 2670 2680 2690 2700
pF1KE9 LTGEERVPVVNKRNGKKMGGAMAPPMKDLPRWLEENPEFAVAPDWTDIVKQSGFVPESMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LTGEERVPVVNKRNGKKMGGAMAPPMKDLPRWLEENPEFAVAPDWTDIVKQSGFVPESMF
2650 2660 2670 2680 2690 2700
2710 2720 2730 2740 2750 2760
pF1KE9 DRLLTGPVVRGEGASRRGRRPKSEIARAAAAAAAVASTSGINPLLVNSLFAGMDLTSLQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 DRLLTGPVVRGEGASRRGRRPKSEIARAAAAAAAVASTSGINPLLVNSLFAGMDLTSLQN
2710 2720 2730 2740 2750 2760
2770 2780 2790 2800 2810 2820
pF1KE9 LQNLQSLQLAGLMGFPPGLATAATAGGDAKNPAAVLPLMLPGMAGLPNVFGLGGLLNNPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LQNLQSLQLAGLMGFPPGLATAATAGGDAKNPAAVLPLMLPGMAGLPNVFGLGGLLNNPL
2770 2780 2790 2800 2810 2820
2830 2840 2850 2860 2870 2880
pF1KE9 SAATGNTTTASSQGEPEDSTSKGEEKGNENEDENKDSEKSTDAVSAADSANGSVGAATAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SAATGNTTTASSQGEPEDSTSKGEEKGNENEDENKDSEKSTDAVSAADSANGSVGAATAP
2830 2840 2850 2860 2870 2880
2890 2900 2910 2920 2930 2940
pF1KE9 AGLPSNPLAFNPFLLSTMAPGLFYPSMFLPPGLGGLTLPGFPALAGLQNAVGSSEEKAAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 AGLPSNPLAFNPFLLSTMAPGLFYPSMFLPPGLGGLTLPGFPALAGLQNAVGSSEEKAAD
2890 2900 2910 2920 2930 2940
2950 2960 2970 2980 2990
pF1KE9 KAEGGPFKDGETLEGSDAEESLDKTAESSLLEDEIAQGEELDSLDGGDEIENNENDE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 KAEGGPFKDGETLEGSDAEESLDKTAESSLLEDEIAQGEELDSLDGGDEIENNENDE
2950 2960 2970 2980 2990
>>XP_016869102 (OMIM: 189960,214800,608892,612370) PREDI (2996 aa)
initn: 15488 init1: 15488 opt: 20297 Z-score: 7791.6 bits: 1456.4 E(85289): 0
Smith-Waterman score: 20297; 100.0% identity (100.0% similar) in 2997 aa overlap (1-2997:1-2996)
10 20 30 40 50 60
pF1KE9 MADPGMMSLFGEDGNIFSEGLEGLGECGYPENPVNPMGQQMPIDQGFASLQPSLHHPSTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MADPGMMSLFGEDGNIFSEGLEGLGECGYPENPVNPMGQQMPIDQGFASLQPSLHHPSTN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 QNQTKLTHFDHYNQYEQQKMHLMDQPNRMMSNTPGNGLASPHSQYHTPPVPQVPHGGSGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNQTKLTHFDHYNQYEQQKMHLMDQPNRMMSNTPGNGLASPHSQYHTPPVPQVPHGGSGG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 GQMGVYPGMQNERHGQSFVDSSSMWGPRAVQVPDQIRAPYQQQQPQPQPPQPAPSGPPAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQMGVYPGMQNERHGQSFVDSSSMWGPRAVQVPDQIRAPYQQQQPQPQPPQPAPSGPPAQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 GHPQHMQQMGSYMARGDFSMQQHGQPQQRMSQFSQGQEGLNQGNPFIATSGPGHLSHVPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GHPQHMQQMGSYMARGDFSMQQHGQPQQRMSQFSQGQEGLNQGNPFIATSGPGHLSHVPQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 QSPSMAPSLRHSVQQFHHHPSTALHGESVAHSPRFSPNPPQQGAVRPQTLNFSSRSQTVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSPSMAPSLRHSVQQFHHHPSTALHGESVAHSPRFSPNPPQQGAVRPQTLNFSSRSQTVP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 SPTINNSGQYSRYPYSNLNQGLVNNTGMNQNLGLTNNTPMNQSVPRYPNAVGFPSNSGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPTINNSGQYSRYPYSNLNQGLVNNTGMNQNLGLTNNTPMNQSVPRYPNAVGFPSNSGQG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 LMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNPAGTPPPQVRPGSAGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNPAGTPPPQVRPGSAGI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 PMEVGSYPNMPHPQPSHQPPGAMGIGQRNMGPRNMQQSRPFIGMSSAPRELTGHMRPNGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PMEVGSYPNMPHPQPSHQPPGAMGIGQRNMGPRNMQQSRPFIGMSSAPRELTGHMRPNGC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 PGVGLGDPQAIQERLIPGQQHPGQQPSFQQLPTCPPLQPHPGLHHQSSPPHPHHQPWAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGVGLGDPQAIQERLIPGQQHPGQQPSFQQLPTCPPLQPHPGLHHQSSPPHPHHQPWAQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 HPSPQNTPQKVPVHQHSPSEPFLEKPVPDMTQVSGPNAQLVKSDDYLPSIEQQPQQKKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPSPQNTPQKVPVHQHSPSEPFLEKPVPDMTQVSGPNAQLVKSDDYLPSIEQQPQQKKKK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 KKNNHIVAEDPSKGFGKDDFPGGVDNQELNRNSLDGSQEEKKKKKRSKAKKDPKEPKEPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKNNHIVAEDPSKGFGKDDFPGGVDNQELNRNSLDGSQEEKKKKKRSKAKKDPKEPKEPK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 EKKEPKEPKTPKAPKIPKEPKEKKAKTATPKPKSSKKSSNKKPDSEASALKKKVNKGKTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKKEPKEPKTPKAPKIPKEPKEKKAKTATPKPKSSKKSSNKKPDSEASALKKKVNKGKTE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 GSENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE9 DSPSNTSQSEQQESVDAEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSPSNTSQSEQQESVDAEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQW
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE9 ASIEDLEKDKRIQQKIKRFKAKQGQNKFLSEIEDELFNPDYVEVDRIMDFARSTDDRGEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASIEDLEKDKRIQQKIKRFKAKQGQNKFLSEIEDELFNPDYVEVDRIMDFARSTDDRGEP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE9 VTHYLVKWCSLPYEDSTWERRQDIDQAKIEEFEKLMSREPETERVERPPADDWKKSESSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTHYLVKWCSLPYEDSTWERRQDIDQAKIEEFEKLMSREPETERVERPPADDWKKSESSR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE9 EYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE9 VIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAI
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE9 ITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNT
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE9 VEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAP
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE9 KEETIIEVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLING
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEETIIEVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLING
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE9 AEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLD
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE9 ILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADT
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE9 CIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQ
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE9 SMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITI
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE9 ESEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRK
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE9 QTRLYSAVKEDELMEFSDLESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGWGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QTRLYSAVKEDELMEFSDLESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGWGR
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE9 WTDILSHGRYKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WTDILSHGRYKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRALV
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE9 NHSGLSAPVPRGRKGKKVKAQSTQPVVQDADWLASCNPDALFQEDSYKKHLKHHCNKVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NHSGLSAPVPRGRKGKKVKAQSTQPVVQDADWLASCNPDALFQEDSYKKHLKHHCNKVLL
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE9 RVRMLYYLRQEVIGDQADKILEGADSSEADVWIPEPFHAEVPADWWDKEADKSLLIGVFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVRMLYYLRQEVIGDQADKILEGADSSEADVWIPEPFHAEVPADWWDKEADKSLLIGVFK
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE9 HGYEKYNSMRADPALCFLERVGMPDAKAIAAEQRGTDMLADGGDGGEFDREDEDPEYKPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HGYEKYNSMRADPALCFLERVGMPDAKAIAAEQRGTDMLADGGDGGEFDREDEDPEYKPT
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE9 RTPFKDEIDEFANSPSEDKEESMEIHATGKHSESNAELGQLYWPNTSTLTTRLRRLITAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTPFKDEIDEFANSPSEDKEESMEIHATGKHSESNAELGQLYWPNTSTLTTRLRRLITAY
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE9 QRSYKRQQMRQEALMKTDRRRRRPREEVRALEAEREAIISEKRQKWTRREEADFYRVVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRSYKRQQMRQEALMKTDRRRRRPREEVRALEAEREAIISEKRQKWTRREEADFYRVVST
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE9 FGVIFDPVKQQFDWNQFRAFARLDKKSDESLEKYFSCFVAMCRRVCRMPVKPDDEPPDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGVIFDPVKQQFDWNQFRAFARLDKKSDESLEKYFSCFVAMCRRVCRMPVKPDDEPPDLS
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE9 SIIEPITEERASRTLYRIELLRKIREQVLHHPQLGERLKLCQPSLDLPEWWECGRHDRDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIIEPITEERASRTLYRIELLRKIREQVLHHPQLGERLKLCQPSLDLPEWWECGRHDRDL
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE9 LVGAAKHGVSRTDYHILNDPELSFLDAHKNFAQNRGAGNTSSLNPLAVGFVQTPPVISSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVGAAKHGVSRTDYHILNDPELSFLDAHKNFAQNRGAGNTSSLNPLAVGFVQTPPVISSA
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE9 HIQDERVLEQAEGKVEEPENPAAKEKCEGKEEEEETDGSGKESKQECEAEASSVKNELKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HIQDERVLEQAEGKVEEPENPAAKEKCEGKEEEEETDGSGKESKQECEAEASSVKNELKG
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KE9 VEVGADTGSKSISEKGSEEDEEEKLEDDDKSEESSQPEAGAVSRGKNFDEESNASMSTAR
:::::::::::::::::::::::::::::::::::::: :::::::::::::::::::::
XP_016 VEVGADTGSKSISEKGSEEDEEEKLEDDDKSEESSQPE-GAVSRGKNFDEESNASMSTAR
2230 2240 2250 2260 2270
2290 2300 2310 2320 2330 2340
pF1KE9 DETRDGFYMEDGDPSVAQLLHERTFAFSFWPKDRVMINRLDNICEAVLKGKWPVNRRQMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DETRDGFYMEDGDPSVAQLLHERTFAFSFWPKDRVMINRLDNICEAVLKGKWPVNRRQMF
2280 2290 2300 2310 2320 2330
2350 2360 2370 2380 2390 2400
pF1KE9 DFQGLIPGYTPTTVDSPLQKRSFAELSMVGQASISGSEDITTSPQLSKEDALNLSVPRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFQGLIPGYTPTTVDSPLQKRSFAELSMVGQASISGSEDITTSPQLSKEDALNLSVPRQR
2340 2350 2360 2370 2380 2390
2410 2420 2430 2440 2450 2460
pF1KE9 RRRRRKIEIEAERAAKRRNLMEMVAQLRESQVVSENGQEKVVDLSKASREATSSTSNFSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRRRRKIEIEAERAAKRRNLMEMVAQLRESQVVSENGQEKVVDLSKASREATSSTSNFSS
2400 2410 2420 2430 2440 2450
2470 2480 2490 2500 2510 2520
pF1KE9 LSSKFILPNVSTPVSDAFKTQMELLQAGLSRTPTRHLLNGSLVDGEPPMKRRRGRRKNVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSSKFILPNVSTPVSDAFKTQMELLQAGLSRTPTRHLLNGSLVDGEPPMKRRRGRRKNVE
2460 2470 2480 2490 2500 2510
2530 2540 2550 2560 2570 2580
pF1KE9 GLDLLFMSHKRTSLSAEDAEVTKAFEEDIETPPTRNIPSPGQLDPDTRIPVINLEDGTRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLDLLFMSHKRTSLSAEDAEVTKAFEEDIETPPTRNIPSPGQLDPDTRIPVINLEDGTRL
2520 2530 2540 2550 2560 2570
2590 2600 2610 2620 2630 2640
pF1KE9 VGEDAPKNKDLVEWLKLHPTYTVDMPSYVPKNADVLFSSFQKPKQKRHRCRNPNKLDINT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGEDAPKNKDLVEWLKLHPTYTVDMPSYVPKNADVLFSSFQKPKQKRHRCRNPNKLDINT
2580 2590 2600 2610 2620 2630
2650 2660 2670 2680 2690 2700
pF1KE9 LTGEERVPVVNKRNGKKMGGAMAPPMKDLPRWLEENPEFAVAPDWTDIVKQSGFVPESMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTGEERVPVVNKRNGKKMGGAMAPPMKDLPRWLEENPEFAVAPDWTDIVKQSGFVPESMF
2640 2650 2660 2670 2680 2690
2710 2720 2730 2740 2750 2760
pF1KE9 DRLLTGPVVRGEGASRRGRRPKSEIARAAAAAAAVASTSGINPLLVNSLFAGMDLTSLQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRLLTGPVVRGEGASRRGRRPKSEIARAAAAAAAVASTSGINPLLVNSLFAGMDLTSLQN
2700 2710 2720 2730 2740 2750
2770 2780 2790 2800 2810 2820
pF1KE9 LQNLQSLQLAGLMGFPPGLATAATAGGDAKNPAAVLPLMLPGMAGLPNVFGLGGLLNNPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQNLQSLQLAGLMGFPPGLATAATAGGDAKNPAAVLPLMLPGMAGLPNVFGLGGLLNNPL
2760 2770 2780 2790 2800 2810
2830 2840 2850 2860 2870 2880
pF1KE9 SAATGNTTTASSQGEPEDSTSKGEEKGNENEDENKDSEKSTDAVSAADSANGSVGAATAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAATGNTTTASSQGEPEDSTSKGEEKGNENEDENKDSEKSTDAVSAADSANGSVGAATAP
2820 2830 2840 2850 2860 2870
2890 2900 2910 2920 2930 2940
pF1KE9 AGLPSNPLAFNPFLLSTMAPGLFYPSMFLPPGLGGLTLPGFPALAGLQNAVGSSEEKAAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGLPSNPLAFNPFLLSTMAPGLFYPSMFLPPGLGGLTLPGFPALAGLQNAVGSSEEKAAD
2880 2890 2900 2910 2920 2930
2950 2960 2970 2980 2990
pF1KE9 KAEGGPFKDGETLEGSDAEESLDKTAESSLLEDEIAQGEELDSLDGGDEIENNENDE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAEGGPFKDGETLEGSDAEESLDKTAESSLLEDEIAQGEELDSLDGGDEIENNENDE
2940 2950 2960 2970 2980 2990
>>XP_011515857 (OMIM: 189960,214800,608892,612370) PREDI (3026 aa)
initn: 16825 init1: 11978 opt: 11978 Z-score: 4604.8 bits: 866.7 E(85289): 0
Smith-Waterman score: 20221; 98.9% identity (99.0% similar) in 3027 aa overlap (1-2997:1-3026)
10 20 30 40 50 60
pF1KE9 MADPGMMSLFGEDGNIFSEGLEGLGECGYPENPVNPMGQQMPIDQGFASLQPSLHHPSTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MADPGMMSLFGEDGNIFSEGLEGLGECGYPENPVNPMGQQMPIDQGFASLQPSLHHPSTN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 QNQTKLTHFDHYNQYEQQKMHLMDQPNRMMSNTPGNGLASPHSQYHTPPVPQVPHGGSGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QNQTKLTHFDHYNQYEQQKMHLMDQPNRMMSNTPGNGLASPHSQYHTPPVPQVPHGGSGG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 GQMGVYPGMQNERHGQSFVDSSSMWGPRAVQVPDQIRAPYQQQQPQPQPPQPAPSGPPAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQMGVYPGMQNERHGQSFVDSSSMWGPRAVQVPDQIRAPYQQQQPQPQPPQPAPSGPPAQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 GHPQHMQQMGSYMARGDFSMQQHGQPQQRMSQFSQGQEGLNQGNPFIATSGPGHLSHVPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GHPQHMQQMGSYMARGDFSMQQHGQPQQRMSQFSQGQEGLNQGNPFIATSGPGHLSHVPQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 QSPSMAPSLRHSVQQFHHHPSTALHGESVAHSPRFSPNPPQQGAVRPQTLNFSSRSQTVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSPSMAPSLRHSVQQFHHHPSTALHGESVAHSPRFSPNPPQQGAVRPQTLNFSSRSQTVP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 SPTINNSGQYSRYPYSNLNQGLVNNTGMNQNLGLTNNTPMNQSVPRYPNAVGFPSNSGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPTINNSGQYSRYPYSNLNQGLVNNTGMNQNLGLTNNTPMNQSVPRYPNAVGFPSNSGQG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 LMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNPAGTPPPQVRPGSAGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNPAGTPPPQVRPGSAGI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 PMEVGSYPNMPHPQPSHQPPGAMGIGQRNMGPRNMQQSRPFIGMSSAPRELTGHMRPNGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PMEVGSYPNMPHPQPSHQPPGAMGIGQRNMGPRNMQQSRPFIGMSSAPRELTGHMRPNGC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 PGVGLGDPQAIQERLIPGQQHPGQQPSFQQLPTCPPLQPHPGLHHQSSPPHPHHQPWAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGVGLGDPQAIQERLIPGQQHPGQQPSFQQLPTCPPLQPHPGLHHQSSPPHPHHQPWAQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 HPSPQNTPQKVPVHQHSPSEPFLEKPVPDMTQVSGPNAQLVKSDDYLPSIEQQPQQKKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPSPQNTPQKVPVHQHSPSEPFLEKPVPDMTQVSGPNAQLVKSDDYLPSIEQQPQQKKKK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 KKNNHIVAEDPSKGFGKDDFPGGVDNQELNRNSLDGSQEEKKKKKRSKAKKDPKEPKEPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKNNHIVAEDPSKGFGKDDFPGGVDNQELNRNSLDGSQEEKKKKKRSKAKKDPKEPKEPK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 EKKEPKEPKTPKAPKIPKEPKEKKAKTATPKPKSSKKSSNKKPDSEASALKKKVNKGKTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKKEPKEPKTPKAPKIPKEPKEKKAKTATPKPKSSKKSSNKKPDSEASALKKKVNKGKTE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 GSENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE9 DSPSNTSQSEQQESVDAEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSPSNTSQSEQQESVDAEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQW
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE9 ASIEDLEKDKRIQQKIKRFKAKQGQNKFLSEIEDELFNPDYVEVDRIMDFARSTDDRGEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASIEDLEKDKRIQQKIKRFKAKQGQNKFLSEIEDELFNPDYVEVDRIMDFARSTDDRGEP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE9 VTHYLVKWCSLPYEDSTWERRQDIDQAKIEEFEKLMSREPETERVERPPADDWKKSESSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTHYLVKWCSLPYEDSTWERRQDIDQAKIEEFEKLMSREPETERVERPPADDWKKSESSR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE9 EYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE9 VIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAI
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE9 ITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNT
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE9 VEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAP
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE9 KEETIIEVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLING
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEETIIEVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLING
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE9 AEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLD
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE9 ILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADT
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE9 CIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQ
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE9 SMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITI
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE9 ESEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRK
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE9 QTRLYSAVKEDELMEFSDLESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGWGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTRLYSAVKEDELMEFSDLESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGWGR
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE9 WTDILSHGRYKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WTDILSHGRYKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRALV
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730
pF1KE9 NHSGLSAPVPRGRKGKKVKAQSTQPVVQDADWLASCNPDALFQEDSYKKHLKHHCNK---
::::::::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_011 NHSGLSAPVPRGRKGKKVKAQSTQPVVQDADWLASCNPDALFQEDSYKKHLKHHCNNSGN
1690 1700 1710 1720 1730 1740
1740 1750 1760 1770
pF1KE9 ---------------------------VLLRVRMLYYLRQEVIGDQADKILEGADSSEAD
:::::::::::::::::::::::::::::::::
XP_011 NATDQLYVLASCDLEQVIQPLEDSLSWVLLRVRMLYYLRQEVIGDQADKILEGADSSEAD
1750 1760 1770 1780 1790 1800
1780 1790 1800 1810 1820 1830
pF1KE9 VWIPEPFHAEVPADWWDKEADKSLLIGVFKHGYEKYNSMRADPALCFLERVGMPDAKAIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VWIPEPFHAEVPADWWDKEADKSLLIGVFKHGYEKYNSMRADPALCFLERVGMPDAKAIA
1810 1820 1830 1840 1850 1860
1840 1850 1860 1870 1880 1890
pF1KE9 AEQRGTDMLADGGDGGEFDREDEDPEYKPTRTPFKDEIDEFANSPSEDKEESMEIHATGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEQRGTDMLADGGDGGEFDREDEDPEYKPTRTPFKDEIDEFANSPSEDKEESMEIHATGK
1870 1880 1890 1900 1910 1920
1900 1910 1920 1930 1940 1950
pF1KE9 HSESNAELGQLYWPNTSTLTTRLRRLITAYQRSYKRQQMRQEALMKTDRRRRRPREEVRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSESNAELGQLYWPNTSTLTTRLRRLITAYQRSYKRQQMRQEALMKTDRRRRRPREEVRA
1930 1940 1950 1960 1970 1980
1960 1970 1980 1990 2000 2010
pF1KE9 LEAEREAIISEKRQKWTRREEADFYRVVSTFGVIFDPVKQQFDWNQFRAFARLDKKSDES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEAEREAIISEKRQKWTRREEADFYRVVSTFGVIFDPVKQQFDWNQFRAFARLDKKSDES
1990 2000 2010 2020 2030 2040
2020 2030 2040 2050 2060 2070
pF1KE9 LEKYFSCFVAMCRRVCRMPVKPDDEPPDLSSIIEPITEERASRTLYRIELLRKIREQVLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEKYFSCFVAMCRRVCRMPVKPDDEPPDLSSIIEPITEERASRTLYRIELLRKIREQVLH
2050 2060 2070 2080 2090 2100
2080 2090 2100 2110 2120 2130
pF1KE9 HPQLGERLKLCQPSLDLPEWWECGRHDRDLLVGAAKHGVSRTDYHILNDPELSFLDAHKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPQLGERLKLCQPSLDLPEWWECGRHDRDLLVGAAKHGVSRTDYHILNDPELSFLDAHKN
2110 2120 2130 2140 2150 2160
2140 2150 2160 2170 2180 2190
pF1KE9 FAQNRGAGNTSSLNPLAVGFVQTPPVISSAHIQDERVLEQAEGKVEEPENPAAKEKCEGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAQNRGAGNTSSLNPLAVGFVQTPPVISSAHIQDERVLEQAEGKVEEPENPAAKEKCEGK
2170 2180 2190 2200 2210 2220
2200 2210 2220 2230 2240 2250
pF1KE9 EEEEETDGSGKESKQECEAEASSVKNELKGVEVGADTGSKSISEKGSEEDEEEKLEDDDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEEEETDGSGKESKQECEAEASSVKNELKGVEVGADTGSKSISEKGSEEDEEEKLEDDDK
2230 2240 2250 2260 2270 2280
2260 2270 2280 2290 2300 2310
pF1KE9 SEESSQPEAGAVSRGKNFDEESNASMSTARDETRDGFYMEDGDPSVAQLLHERTFAFSFW
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEESSQPE-GAVSRGKNFDEESNASMSTARDETRDGFYMEDGDPSVAQLLHERTFAFSFW
2290 2300 2310 2320 2330
2320 2330 2340 2350 2360 2370
pF1KE9 PKDRVMINRLDNICEAVLKGKWPVNRRQMFDFQGLIPGYTPTTVDSPLQKRSFAELSMVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PKDRVMINRLDNICEAVLKGKWPVNRRQMFDFQGLIPGYTPTTVDSPLQKRSFAELSMVG
2340 2350 2360 2370 2380 2390
2380 2390 2400 2410 2420 2430
pF1KE9 QASISGSEDITTSPQLSKEDALNLSVPRQRRRRRRKIEIEAERAAKRRNLMEMVAQLRES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QASISGSEDITTSPQLSKEDALNLSVPRQRRRRRRKIEIEAERAAKRRNLMEMVAQLRES
2400 2410 2420 2430 2440 2450
2440 2450 2460 2470 2480 2490
pF1KE9 QVVSENGQEKVVDLSKASREATSSTSNFSSLSSKFILPNVSTPVSDAFKTQMELLQAGLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVVSENGQEKVVDLSKASREATSSTSNFSSLSSKFILPNVSTPVSDAFKTQMELLQAGLS
2460 2470 2480 2490 2500 2510
2500 2510 2520 2530 2540 2550
pF1KE9 RTPTRHLLNGSLVDGEPPMKRRRGRRKNVEGLDLLFMSHKRTSLSAEDAEVTKAFEEDIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTPTRHLLNGSLVDGEPPMKRRRGRRKNVEGLDLLFMSHKRTSLSAEDAEVTKAFEEDIE
2520 2530 2540 2550 2560 2570
2560 2570 2580 2590 2600 2610
pF1KE9 TPPTRNIPSPGQLDPDTRIPVINLEDGTRLVGEDAPKNKDLVEWLKLHPTYTVDMPSYVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPPTRNIPSPGQLDPDTRIPVINLEDGTRLVGEDAPKNKDLVEWLKLHPTYTVDMPSYVP
2580 2590 2600 2610 2620 2630
2620 2630 2640 2650 2660 2670
pF1KE9 KNADVLFSSFQKPKQKRHRCRNPNKLDINTLTGEERVPVVNKRNGKKMGGAMAPPMKDLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNADVLFSSFQKPKQKRHRCRNPNKLDINTLTGEERVPVVNKRNGKKMGGAMAPPMKDLP
2640 2650 2660 2670 2680 2690
2680 2690 2700 2710 2720 2730
pF1KE9 RWLEENPEFAVAPDWTDIVKQSGFVPESMFDRLLTGPVVRGEGASRRGRRPKSEIARAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RWLEENPEFAVAPDWTDIVKQSGFVPESMFDRLLTGPVVRGEGASRRGRRPKSEIARAAA
2700 2710 2720 2730 2740 2750
2740 2750 2760 2770 2780 2790
pF1KE9 AAAAVASTSGINPLLVNSLFAGMDLTSLQNLQNLQSLQLAGLMGFPPGLATAATAGGDAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAAAVASTSGINPLLVNSLFAGMDLTSLQNLQNLQSLQLAGLMGFPPGLATAATAGGDAK
2760 2770 2780 2790 2800 2810
2800 2810 2820 2830 2840 2850
pF1KE9 NPAAVLPLMLPGMAGLPNVFGLGGLLNNPLSAATGNTTTASSQGEPEDSTSKGEEKGNEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPAAVLPLMLPGMAGLPNVFGLGGLLNNPLSAATGNTTTASSQGEPEDSTSKGEEKGNEN
2820 2830 2840 2850 2860 2870
2860 2870 2880 2890 2900 2910
pF1KE9 EDENKDSEKSTDAVSAADSANGSVGAATAPAGLPSNPLAFNPFLLSTMAPGLFYPSMFLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDENKDSEKSTDAVSAADSANGSVGAATAPAGLPSNPLAFNPFLLSTMAPGLFYPSMFLP
2880 2890 2900 2910 2920 2930
2920 2930 2940 2950 2960 2970
pF1KE9 PGLGGLTLPGFPALAGLQNAVGSSEEKAADKAEGGPFKDGETLEGSDAEESLDKTAESSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGLGGLTLPGFPALAGLQNAVGSSEEKAADKAEGGPFKDGETLEGSDAEESLDKTAESSL
2940 2950 2960 2970 2980 2990
2980 2990
pF1KE9 LEDEIAQGEELDSLDGGDEIENNENDE
:::::::::::::::::::::::::::
XP_011 LEDEIAQGEELDSLDGGDEIENNENDE
3000 3010 3020
>>XP_011515856 (OMIM: 189960,214800,608892,612370) PREDI (3027 aa)
initn: 20294 init1: 11978 opt: 11978 Z-score: 4604.8 bits: 866.7 E(85289): 0
Smith-Waterman score: 20238; 99.0% identity (99.0% similar) in 3027 aa overlap (1-2997:1-3027)
10 20 30 40 50 60
pF1KE9 MADPGMMSLFGEDGNIFSEGLEGLGECGYPENPVNPMGQQMPIDQGFASLQPSLHHPSTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MADPGMMSLFGEDGNIFSEGLEGLGECGYPENPVNPMGQQMPIDQGFASLQPSLHHPSTN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 QNQTKLTHFDHYNQYEQQKMHLMDQPNRMMSNTPGNGLASPHSQYHTPPVPQVPHGGSGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QNQTKLTHFDHYNQYEQQKMHLMDQPNRMMSNTPGNGLASPHSQYHTPPVPQVPHGGSGG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 GQMGVYPGMQNERHGQSFVDSSSMWGPRAVQVPDQIRAPYQQQQPQPQPPQPAPSGPPAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQMGVYPGMQNERHGQSFVDSSSMWGPRAVQVPDQIRAPYQQQQPQPQPPQPAPSGPPAQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 GHPQHMQQMGSYMARGDFSMQQHGQPQQRMSQFSQGQEGLNQGNPFIATSGPGHLSHVPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GHPQHMQQMGSYMARGDFSMQQHGQPQQRMSQFSQGQEGLNQGNPFIATSGPGHLSHVPQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 QSPSMAPSLRHSVQQFHHHPSTALHGESVAHSPRFSPNPPQQGAVRPQTLNFSSRSQTVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSPSMAPSLRHSVQQFHHHPSTALHGESVAHSPRFSPNPPQQGAVRPQTLNFSSRSQTVP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 SPTINNSGQYSRYPYSNLNQGLVNNTGMNQNLGLTNNTPMNQSVPRYPNAVGFPSNSGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPTINNSGQYSRYPYSNLNQGLVNNTGMNQNLGLTNNTPMNQSVPRYPNAVGFPSNSGQG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 LMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNPAGTPPPQVRPGSAGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNPAGTPPPQVRPGSAGI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 PMEVGSYPNMPHPQPSHQPPGAMGIGQRNMGPRNMQQSRPFIGMSSAPRELTGHMRPNGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PMEVGSYPNMPHPQPSHQPPGAMGIGQRNMGPRNMQQSRPFIGMSSAPRELTGHMRPNGC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 PGVGLGDPQAIQERLIPGQQHPGQQPSFQQLPTCPPLQPHPGLHHQSSPPHPHHQPWAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGVGLGDPQAIQERLIPGQQHPGQQPSFQQLPTCPPLQPHPGLHHQSSPPHPHHQPWAQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 HPSPQNTPQKVPVHQHSPSEPFLEKPVPDMTQVSGPNAQLVKSDDYLPSIEQQPQQKKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPSPQNTPQKVPVHQHSPSEPFLEKPVPDMTQVSGPNAQLVKSDDYLPSIEQQPQQKKKK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 KKNNHIVAEDPSKGFGKDDFPGGVDNQELNRNSLDGSQEEKKKKKRSKAKKDPKEPKEPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKNNHIVAEDPSKGFGKDDFPGGVDNQELNRNSLDGSQEEKKKKKRSKAKKDPKEPKEPK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 EKKEPKEPKTPKAPKIPKEPKEKKAKTATPKPKSSKKSSNKKPDSEASALKKKVNKGKTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKKEPKEPKTPKAPKIPKEPKEKKAKTATPKPKSSKKSSNKKPDSEASALKKKVNKGKTE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 GSENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE9 DSPSNTSQSEQQESVDAEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSPSNTSQSEQQESVDAEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQW
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE9 ASIEDLEKDKRIQQKIKRFKAKQGQNKFLSEIEDELFNPDYVEVDRIMDFARSTDDRGEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASIEDLEKDKRIQQKIKRFKAKQGQNKFLSEIEDELFNPDYVEVDRIMDFARSTDDRGEP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE9 VTHYLVKWCSLPYEDSTWERRQDIDQAKIEEFEKLMSREPETERVERPPADDWKKSESSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTHYLVKWCSLPYEDSTWERRQDIDQAKIEEFEKLMSREPETERVERPPADDWKKSESSR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE9 EYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE9 VIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAI
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE9 ITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNT
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE9 VEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAP
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE9 KEETIIEVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLING
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEETIIEVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLING
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE9 AEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLD
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE9 ILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADT
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE9 CIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQ
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE9 SMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITI
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE9 ESEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRK
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE9 QTRLYSAVKEDELMEFSDLESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGWGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTRLYSAVKEDELMEFSDLESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGWGR
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE9 WTDILSHGRYKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WTDILSHGRYKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRALV
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730
pF1KE9 NHSGLSAPVPRGRKGKKVKAQSTQPVVQDADWLASCNPDALFQEDSYKKHLKHHCNK---
::::::::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_011 NHSGLSAPVPRGRKGKKVKAQSTQPVVQDADWLASCNPDALFQEDSYKKHLKHHCNNSGN
1690 1700 1710 1720 1730 1740
1740 1750 1760 1770
pF1KE9 ---------------------------VLLRVRMLYYLRQEVIGDQADKILEGADSSEAD
:::::::::::::::::::::::::::::::::
XP_011 NATDQLYVLASCDLEQVIQPLEDSLSWVLLRVRMLYYLRQEVIGDQADKILEGADSSEAD
1750 1760 1770 1780 1790 1800
1780 1790 1800 1810 1820 1830
pF1KE9 VWIPEPFHAEVPADWWDKEADKSLLIGVFKHGYEKYNSMRADPALCFLERVGMPDAKAIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VWIPEPFHAEVPADWWDKEADKSLLIGVFKHGYEKYNSMRADPALCFLERVGMPDAKAIA
1810 1820 1830 1840 1850 1860
1840 1850 1860 1870 1880 1890
pF1KE9 AEQRGTDMLADGGDGGEFDREDEDPEYKPTRTPFKDEIDEFANSPSEDKEESMEIHATGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEQRGTDMLADGGDGGEFDREDEDPEYKPTRTPFKDEIDEFANSPSEDKEESMEIHATGK
1870 1880 1890 1900 1910 1920
1900 1910 1920 1930 1940 1950
pF1KE9 HSESNAELGQLYWPNTSTLTTRLRRLITAYQRSYKRQQMRQEALMKTDRRRRRPREEVRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSESNAELGQLYWPNTSTLTTRLRRLITAYQRSYKRQQMRQEALMKTDRRRRRPREEVRA
1930 1940 1950 1960 1970 1980
1960 1970 1980 1990 2000 2010
pF1KE9 LEAEREAIISEKRQKWTRREEADFYRVVSTFGVIFDPVKQQFDWNQFRAFARLDKKSDES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEAEREAIISEKRQKWTRREEADFYRVVSTFGVIFDPVKQQFDWNQFRAFARLDKKSDES
1990 2000 2010 2020 2030 2040
2020 2030 2040 2050 2060 2070
pF1KE9 LEKYFSCFVAMCRRVCRMPVKPDDEPPDLSSIIEPITEERASRTLYRIELLRKIREQVLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEKYFSCFVAMCRRVCRMPVKPDDEPPDLSSIIEPITEERASRTLYRIELLRKIREQVLH
2050 2060 2070 2080 2090 2100
2080 2090 2100 2110 2120 2130
pF1KE9 HPQLGERLKLCQPSLDLPEWWECGRHDRDLLVGAAKHGVSRTDYHILNDPELSFLDAHKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPQLGERLKLCQPSLDLPEWWECGRHDRDLLVGAAKHGVSRTDYHILNDPELSFLDAHKN
2110 2120 2130 2140 2150 2160
2140 2150 2160 2170 2180 2190
pF1KE9 FAQNRGAGNTSSLNPLAVGFVQTPPVISSAHIQDERVLEQAEGKVEEPENPAAKEKCEGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAQNRGAGNTSSLNPLAVGFVQTPPVISSAHIQDERVLEQAEGKVEEPENPAAKEKCEGK
2170 2180 2190 2200 2210 2220
2200 2210 2220 2230 2240 2250
pF1KE9 EEEEETDGSGKESKQECEAEASSVKNELKGVEVGADTGSKSISEKGSEEDEEEKLEDDDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEEEETDGSGKESKQECEAEASSVKNELKGVEVGADTGSKSISEKGSEEDEEEKLEDDDK
2230 2240 2250 2260 2270 2280
2260 2270 2280 2290 2300 2310
pF1KE9 SEESSQPEAGAVSRGKNFDEESNASMSTARDETRDGFYMEDGDPSVAQLLHERTFAFSFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEESSQPEAGAVSRGKNFDEESNASMSTARDETRDGFYMEDGDPSVAQLLHERTFAFSFW
2290 2300 2310 2320 2330 2340
2320 2330 2340 2350 2360 2370
pF1KE9 PKDRVMINRLDNICEAVLKGKWPVNRRQMFDFQGLIPGYTPTTVDSPLQKRSFAELSMVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PKDRVMINRLDNICEAVLKGKWPVNRRQMFDFQGLIPGYTPTTVDSPLQKRSFAELSMVG
2350 2360 2370 2380 2390 2400
2380 2390 2400 2410 2420 2430
pF1KE9 QASISGSEDITTSPQLSKEDALNLSVPRQRRRRRRKIEIEAERAAKRRNLMEMVAQLRES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QASISGSEDITTSPQLSKEDALNLSVPRQRRRRRRKIEIEAERAAKRRNLMEMVAQLRES
2410 2420 2430 2440 2450 2460
2440 2450 2460 2470 2480 2490
pF1KE9 QVVSENGQEKVVDLSKASREATSSTSNFSSLSSKFILPNVSTPVSDAFKTQMELLQAGLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVVSENGQEKVVDLSKASREATSSTSNFSSLSSKFILPNVSTPVSDAFKTQMELLQAGLS
2470 2480 2490 2500 2510 2520
2500 2510 2520 2530 2540 2550
pF1KE9 RTPTRHLLNGSLVDGEPPMKRRRGRRKNVEGLDLLFMSHKRTSLSAEDAEVTKAFEEDIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTPTRHLLNGSLVDGEPPMKRRRGRRKNVEGLDLLFMSHKRTSLSAEDAEVTKAFEEDIE
2530 2540 2550 2560 2570 2580
2560 2570 2580 2590 2600 2610
pF1KE9 TPPTRNIPSPGQLDPDTRIPVINLEDGTRLVGEDAPKNKDLVEWLKLHPTYTVDMPSYVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPPTRNIPSPGQLDPDTRIPVINLEDGTRLVGEDAPKNKDLVEWLKLHPTYTVDMPSYVP
2590 2600 2610 2620 2630 2640
2620 2630 2640 2650 2660 2670
pF1KE9 KNADVLFSSFQKPKQKRHRCRNPNKLDINTLTGEERVPVVNKRNGKKMGGAMAPPMKDLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNADVLFSSFQKPKQKRHRCRNPNKLDINTLTGEERVPVVNKRNGKKMGGAMAPPMKDLP
2650 2660 2670 2680 2690 2700
2680 2690 2700 2710 2720 2730
pF1KE9 RWLEENPEFAVAPDWTDIVKQSGFVPESMFDRLLTGPVVRGEGASRRGRRPKSEIARAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RWLEENPEFAVAPDWTDIVKQSGFVPESMFDRLLTGPVVRGEGASRRGRRPKSEIARAAA
2710 2720 2730 2740 2750 2760
2740 2750 2760 2770 2780 2790
pF1KE9 AAAAVASTSGINPLLVNSLFAGMDLTSLQNLQNLQSLQLAGLMGFPPGLATAATAGGDAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAAAVASTSGINPLLVNSLFAGMDLTSLQNLQNLQSLQLAGLMGFPPGLATAATAGGDAK
2770 2780 2790 2800 2810 2820
2800 2810 2820 2830 2840 2850
pF1KE9 NPAAVLPLMLPGMAGLPNVFGLGGLLNNPLSAATGNTTTASSQGEPEDSTSKGEEKGNEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPAAVLPLMLPGMAGLPNVFGLGGLLNNPLSAATGNTTTASSQGEPEDSTSKGEEKGNEN
2830 2840 2850 2860 2870 2880
2860 2870 2880 2890 2900 2910
pF1KE9 EDENKDSEKSTDAVSAADSANGSVGAATAPAGLPSNPLAFNPFLLSTMAPGLFYPSMFLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDENKDSEKSTDAVSAADSANGSVGAATAPAGLPSNPLAFNPFLLSTMAPGLFYPSMFLP
2890 2900 2910 2920 2930 2940
2920 2930 2940 2950 2960 2970
pF1KE9 PGLGGLTLPGFPALAGLQNAVGSSEEKAADKAEGGPFKDGETLEGSDAEESLDKTAESSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGLGGLTLPGFPALAGLQNAVGSSEEKAADKAEGGPFKDGETLEGSDAEESLDKTAESSL
2950 2960 2970 2980 2990 3000
2980 2990
pF1KE9 LEDEIAQGEELDSLDGGDEIENNENDE
:::::::::::::::::::::::::::
XP_011 LEDEIAQGEELDSLDGGDEIENNENDE
3010 3020
>>XP_016869101 (OMIM: 189960,214800,608892,612370) PREDI (3027 aa)
initn: 20294 init1: 11978 opt: 11978 Z-score: 4604.8 bits: 866.7 E(85289): 0
Smith-Waterman score: 20238; 99.0% identity (99.0% similar) in 3027 aa overlap (1-2997:1-3027)
10 20 30 40 50 60
pF1KE9 MADPGMMSLFGEDGNIFSEGLEGLGECGYPENPVNPMGQQMPIDQGFASLQPSLHHPSTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MADPGMMSLFGEDGNIFSEGLEGLGECGYPENPVNPMGQQMPIDQGFASLQPSLHHPSTN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 QNQTKLTHFDHYNQYEQQKMHLMDQPNRMMSNTPGNGLASPHSQYHTPPVPQVPHGGSGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNQTKLTHFDHYNQYEQQKMHLMDQPNRMMSNTPGNGLASPHSQYHTPPVPQVPHGGSGG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 GQMGVYPGMQNERHGQSFVDSSSMWGPRAVQVPDQIRAPYQQQQPQPQPPQPAPSGPPAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQMGVYPGMQNERHGQSFVDSSSMWGPRAVQVPDQIRAPYQQQQPQPQPPQPAPSGPPAQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 GHPQHMQQMGSYMARGDFSMQQHGQPQQRMSQFSQGQEGLNQGNPFIATSGPGHLSHVPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GHPQHMQQMGSYMARGDFSMQQHGQPQQRMSQFSQGQEGLNQGNPFIATSGPGHLSHVPQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 QSPSMAPSLRHSVQQFHHHPSTALHGESVAHSPRFSPNPPQQGAVRPQTLNFSSRSQTVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSPSMAPSLRHSVQQFHHHPSTALHGESVAHSPRFSPNPPQQGAVRPQTLNFSSRSQTVP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 SPTINNSGQYSRYPYSNLNQGLVNNTGMNQNLGLTNNTPMNQSVPRYPNAVGFPSNSGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPTINNSGQYSRYPYSNLNQGLVNNTGMNQNLGLTNNTPMNQSVPRYPNAVGFPSNSGQG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 LMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNPAGTPPPQVRPGSAGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNPAGTPPPQVRPGSAGI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 PMEVGSYPNMPHPQPSHQPPGAMGIGQRNMGPRNMQQSRPFIGMSSAPRELTGHMRPNGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PMEVGSYPNMPHPQPSHQPPGAMGIGQRNMGPRNMQQSRPFIGMSSAPRELTGHMRPNGC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 PGVGLGDPQAIQERLIPGQQHPGQQPSFQQLPTCPPLQPHPGLHHQSSPPHPHHQPWAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGVGLGDPQAIQERLIPGQQHPGQQPSFQQLPTCPPLQPHPGLHHQSSPPHPHHQPWAQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 HPSPQNTPQKVPVHQHSPSEPFLEKPVPDMTQVSGPNAQLVKSDDYLPSIEQQPQQKKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPSPQNTPQKVPVHQHSPSEPFLEKPVPDMTQVSGPNAQLVKSDDYLPSIEQQPQQKKKK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 KKNNHIVAEDPSKGFGKDDFPGGVDNQELNRNSLDGSQEEKKKKKRSKAKKDPKEPKEPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKNNHIVAEDPSKGFGKDDFPGGVDNQELNRNSLDGSQEEKKKKKRSKAKKDPKEPKEPK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 EKKEPKEPKTPKAPKIPKEPKEKKAKTATPKPKSSKKSSNKKPDSEASALKKKVNKGKTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKKEPKEPKTPKAPKIPKEPKEKKAKTATPKPKSSKKSSNKKPDSEASALKKKVNKGKTE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 GSENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE9 DSPSNTSQSEQQESVDAEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSPSNTSQSEQQESVDAEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQW
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE9 ASIEDLEKDKRIQQKIKRFKAKQGQNKFLSEIEDELFNPDYVEVDRIMDFARSTDDRGEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASIEDLEKDKRIQQKIKRFKAKQGQNKFLSEIEDELFNPDYVEVDRIMDFARSTDDRGEP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE9 VTHYLVKWCSLPYEDSTWERRQDIDQAKIEEFEKLMSREPETERVERPPADDWKKSESSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTHYLVKWCSLPYEDSTWERRQDIDQAKIEEFEKLMSREPETERVERPPADDWKKSESSR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE9 EYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE9 VIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAI
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE9 ITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNT
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE9 VEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAP
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE9 KEETIIEVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLING
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEETIIEVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLING
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE9 AEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLD
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE9 ILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADT
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE9 CIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQ
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE9 SMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITI
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE9 ESEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRK
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE9 QTRLYSAVKEDELMEFSDLESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGWGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QTRLYSAVKEDELMEFSDLESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGWGR
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE9 WTDILSHGRYKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WTDILSHGRYKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRALV
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730
pF1KE9 NHSGLSAPVPRGRKGKKVKAQSTQPVVQDADWLASCNPDALFQEDSYKKHLKHHCNK---
::::::::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_016 NHSGLSAPVPRGRKGKKVKAQSTQPVVQDADWLASCNPDALFQEDSYKKHLKHHCNNSGN
1690 1700 1710 1720 1730 1740
1740 1750 1760 1770
pF1KE9 ---------------------------VLLRVRMLYYLRQEVIGDQADKILEGADSSEAD
:::::::::::::::::::::::::::::::::
XP_016 NATDQLYVLASCDLEQVIQPLEDSLSWVLLRVRMLYYLRQEVIGDQADKILEGADSSEAD
1750 1760 1770 1780 1790 1800
1780 1790 1800 1810 1820 1830
pF1KE9 VWIPEPFHAEVPADWWDKEADKSLLIGVFKHGYEKYNSMRADPALCFLERVGMPDAKAIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VWIPEPFHAEVPADWWDKEADKSLLIGVFKHGYEKYNSMRADPALCFLERVGMPDAKAIA
1810 1820 1830 1840 1850 1860
1840 1850 1860 1870 1880 1890
pF1KE9 AEQRGTDMLADGGDGGEFDREDEDPEYKPTRTPFKDEIDEFANSPSEDKEESMEIHATGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEQRGTDMLADGGDGGEFDREDEDPEYKPTRTPFKDEIDEFANSPSEDKEESMEIHATGK
1870 1880 1890 1900 1910 1920
1900 1910 1920 1930 1940 1950
pF1KE9 HSESNAELGQLYWPNTSTLTTRLRRLITAYQRSYKRQQMRQEALMKTDRRRRRPREEVRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSESNAELGQLYWPNTSTLTTRLRRLITAYQRSYKRQQMRQEALMKTDRRRRRPREEVRA
1930 1940 1950 1960 1970 1980
1960 1970 1980 1990 2000 2010
pF1KE9 LEAEREAIISEKRQKWTRREEADFYRVVSTFGVIFDPVKQQFDWNQFRAFARLDKKSDES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEAEREAIISEKRQKWTRREEADFYRVVSTFGVIFDPVKQQFDWNQFRAFARLDKKSDES
1990 2000 2010 2020 2030 2040
2020 2030 2040 2050 2060 2070
pF1KE9 LEKYFSCFVAMCRRVCRMPVKPDDEPPDLSSIIEPITEERASRTLYRIELLRKIREQVLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEKYFSCFVAMCRRVCRMPVKPDDEPPDLSSIIEPITEERASRTLYRIELLRKIREQVLH
2050 2060 2070 2080 2090 2100
2080 2090 2100 2110 2120 2130
pF1KE9 HPQLGERLKLCQPSLDLPEWWECGRHDRDLLVGAAKHGVSRTDYHILNDPELSFLDAHKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPQLGERLKLCQPSLDLPEWWECGRHDRDLLVGAAKHGVSRTDYHILNDPELSFLDAHKN
2110 2120 2130 2140 2150 2160
2140 2150 2160 2170 2180 2190
pF1KE9 FAQNRGAGNTSSLNPLAVGFVQTPPVISSAHIQDERVLEQAEGKVEEPENPAAKEKCEGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FAQNRGAGNTSSLNPLAVGFVQTPPVISSAHIQDERVLEQAEGKVEEPENPAAKEKCEGK
2170 2180 2190 2200 2210 2220
2200 2210 2220 2230 2240 2250
pF1KE9 EEEEETDGSGKESKQECEAEASSVKNELKGVEVGADTGSKSISEKGSEEDEEEKLEDDDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEEEETDGSGKESKQECEAEASSVKNELKGVEVGADTGSKSISEKGSEEDEEEKLEDDDK
2230 2240 2250 2260 2270 2280
2260 2270 2280 2290 2300 2310
pF1KE9 SEESSQPEAGAVSRGKNFDEESNASMSTARDETRDGFYMEDGDPSVAQLLHERTFAFSFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEESSQPEAGAVSRGKNFDEESNASMSTARDETRDGFYMEDGDPSVAQLLHERTFAFSFW
2290 2300 2310 2320 2330 2340
2320 2330 2340 2350 2360 2370
pF1KE9 PKDRVMINRLDNICEAVLKGKWPVNRRQMFDFQGLIPGYTPTTVDSPLQKRSFAELSMVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKDRVMINRLDNICEAVLKGKWPVNRRQMFDFQGLIPGYTPTTVDSPLQKRSFAELSMVG
2350 2360 2370 2380 2390 2400
2380 2390 2400 2410 2420 2430
pF1KE9 QASISGSEDITTSPQLSKEDALNLSVPRQRRRRRRKIEIEAERAAKRRNLMEMVAQLRES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QASISGSEDITTSPQLSKEDALNLSVPRQRRRRRRKIEIEAERAAKRRNLMEMVAQLRES
2410 2420 2430 2440 2450 2460
2440 2450 2460 2470 2480 2490
pF1KE9 QVVSENGQEKVVDLSKASREATSSTSNFSSLSSKFILPNVSTPVSDAFKTQMELLQAGLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVVSENGQEKVVDLSKASREATSSTSNFSSLSSKFILPNVSTPVSDAFKTQMELLQAGLS
2470 2480 2490 2500 2510 2520
2500 2510 2520 2530 2540 2550
pF1KE9 RTPTRHLLNGSLVDGEPPMKRRRGRRKNVEGLDLLFMSHKRTSLSAEDAEVTKAFEEDIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTPTRHLLNGSLVDGEPPMKRRRGRRKNVEGLDLLFMSHKRTSLSAEDAEVTKAFEEDIE
2530 2540 2550 2560 2570 2580
2560 2570 2580 2590 2600 2610
pF1KE9 TPPTRNIPSPGQLDPDTRIPVINLEDGTRLVGEDAPKNKDLVEWLKLHPTYTVDMPSYVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPPTRNIPSPGQLDPDTRIPVINLEDGTRLVGEDAPKNKDLVEWLKLHPTYTVDMPSYVP
2590 2600 2610 2620 2630 2640
2620 2630 2640 2650 2660 2670
pF1KE9 KNADVLFSSFQKPKQKRHRCRNPNKLDINTLTGEERVPVVNKRNGKKMGGAMAPPMKDLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNADVLFSSFQKPKQKRHRCRNPNKLDINTLTGEERVPVVNKRNGKKMGGAMAPPMKDLP
2650 2660 2670 2680 2690 2700
2680 2690 2700 2710 2720 2730
pF1KE9 RWLEENPEFAVAPDWTDIVKQSGFVPESMFDRLLTGPVVRGEGASRRGRRPKSEIARAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RWLEENPEFAVAPDWTDIVKQSGFVPESMFDRLLTGPVVRGEGASRRGRRPKSEIARAAA
2710 2720 2730 2740 2750 2760
2740 2750 2760 2770 2780 2790
pF1KE9 AAAAVASTSGINPLLVNSLFAGMDLTSLQNLQNLQSLQLAGLMGFPPGLATAATAGGDAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAAAVASTSGINPLLVNSLFAGMDLTSLQNLQNLQSLQLAGLMGFPPGLATAATAGGDAK
2770 2780 2790 2800 2810 2820
2800 2810 2820 2830 2840 2850
pF1KE9 NPAAVLPLMLPGMAGLPNVFGLGGLLNNPLSAATGNTTTASSQGEPEDSTSKGEEKGNEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPAAVLPLMLPGMAGLPNVFGLGGLLNNPLSAATGNTTTASSQGEPEDSTSKGEEKGNEN
2830 2840 2850 2860 2870 2880
2860 2870 2880 2890 2900 2910
pF1KE9 EDENKDSEKSTDAVSAADSANGSVGAATAPAGLPSNPLAFNPFLLSTMAPGLFYPSMFLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDENKDSEKSTDAVSAADSANGSVGAATAPAGLPSNPLAFNPFLLSTMAPGLFYPSMFLP
2890 2900 2910 2920 2930 2940
2920 2930 2940 2950 2960 2970
pF1KE9 PGLGGLTLPGFPALAGLQNAVGSSEEKAADKAEGGPFKDGETLEGSDAEESLDKTAESSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGLGGLTLPGFPALAGLQNAVGSSEEKAADKAEGGPFKDGETLEGSDAEESLDKTAESSL
2950 2960 2970 2980 2990 3000
2980 2990
pF1KE9 LEDEIAQGEELDSLDGGDEIENNENDE
:::::::::::::::::::::::::::
XP_016 LEDEIAQGEELDSLDGGDEIENNENDE
3010 3020
>>XP_011515855 (OMIM: 189960,214800,608892,612370) PREDI (3027 aa)
initn: 20294 init1: 11978 opt: 11978 Z-score: 4604.8 bits: 866.7 E(85289): 0
Smith-Waterman score: 20238; 99.0% identity (99.0% similar) in 3027 aa overlap (1-2997:1-3027)
10 20 30 40 50 60
pF1KE9 MADPGMMSLFGEDGNIFSEGLEGLGECGYPENPVNPMGQQMPIDQGFASLQPSLHHPSTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MADPGMMSLFGEDGNIFSEGLEGLGECGYPENPVNPMGQQMPIDQGFASLQPSLHHPSTN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 QNQTKLTHFDHYNQYEQQKMHLMDQPNRMMSNTPGNGLASPHSQYHTPPVPQVPHGGSGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QNQTKLTHFDHYNQYEQQKMHLMDQPNRMMSNTPGNGLASPHSQYHTPPVPQVPHGGSGG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 GQMGVYPGMQNERHGQSFVDSSSMWGPRAVQVPDQIRAPYQQQQPQPQPPQPAPSGPPAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQMGVYPGMQNERHGQSFVDSSSMWGPRAVQVPDQIRAPYQQQQPQPQPPQPAPSGPPAQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 GHPQHMQQMGSYMARGDFSMQQHGQPQQRMSQFSQGQEGLNQGNPFIATSGPGHLSHVPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GHPQHMQQMGSYMARGDFSMQQHGQPQQRMSQFSQGQEGLNQGNPFIATSGPGHLSHVPQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 QSPSMAPSLRHSVQQFHHHPSTALHGESVAHSPRFSPNPPQQGAVRPQTLNFSSRSQTVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSPSMAPSLRHSVQQFHHHPSTALHGESVAHSPRFSPNPPQQGAVRPQTLNFSSRSQTVP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 SPTINNSGQYSRYPYSNLNQGLVNNTGMNQNLGLTNNTPMNQSVPRYPNAVGFPSNSGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPTINNSGQYSRYPYSNLNQGLVNNTGMNQNLGLTNNTPMNQSVPRYPNAVGFPSNSGQG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 LMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNPAGTPPPQVRPGSAGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNPAGTPPPQVRPGSAGI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 PMEVGSYPNMPHPQPSHQPPGAMGIGQRNMGPRNMQQSRPFIGMSSAPRELTGHMRPNGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PMEVGSYPNMPHPQPSHQPPGAMGIGQRNMGPRNMQQSRPFIGMSSAPRELTGHMRPNGC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 PGVGLGDPQAIQERLIPGQQHPGQQPSFQQLPTCPPLQPHPGLHHQSSPPHPHHQPWAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGVGLGDPQAIQERLIPGQQHPGQQPSFQQLPTCPPLQPHPGLHHQSSPPHPHHQPWAQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 HPSPQNTPQKVPVHQHSPSEPFLEKPVPDMTQVSGPNAQLVKSDDYLPSIEQQPQQKKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPSPQNTPQKVPVHQHSPSEPFLEKPVPDMTQVSGPNAQLVKSDDYLPSIEQQPQQKKKK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 KKNNHIVAEDPSKGFGKDDFPGGVDNQELNRNSLDGSQEEKKKKKRSKAKKDPKEPKEPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKNNHIVAEDPSKGFGKDDFPGGVDNQELNRNSLDGSQEEKKKKKRSKAKKDPKEPKEPK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 EKKEPKEPKTPKAPKIPKEPKEKKAKTATPKPKSSKKSSNKKPDSEASALKKKVNKGKTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKKEPKEPKTPKAPKIPKEPKEKKAKTATPKPKSSKKSSNKKPDSEASALKKKVNKGKTE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 GSENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE9 DSPSNTSQSEQQESVDAEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSPSNTSQSEQQESVDAEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQW
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE9 ASIEDLEKDKRIQQKIKRFKAKQGQNKFLSEIEDELFNPDYVEVDRIMDFARSTDDRGEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASIEDLEKDKRIQQKIKRFKAKQGQNKFLSEIEDELFNPDYVEVDRIMDFARSTDDRGEP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE9 VTHYLVKWCSLPYEDSTWERRQDIDQAKIEEFEKLMSREPETERVERPPADDWKKSESSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTHYLVKWCSLPYEDSTWERRQDIDQAKIEEFEKLMSREPETERVERPPADDWKKSESSR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE9 EYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE9 VIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAI
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE9 ITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNT
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE9 VEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAP
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE9 KEETIIEVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLING
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEETIIEVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLING
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE9 AEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLD
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE9 ILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADT
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE9 CIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQ
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE9 SMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITI
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE9 ESEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRK
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE9 QTRLYSAVKEDELMEFSDLESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGWGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTRLYSAVKEDELMEFSDLESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGWGR
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE9 WTDILSHGRYKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WTDILSHGRYKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRALV
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730
pF1KE9 NHSGLSAPVPRGRKGKKVKAQSTQPVVQDADWLASCNPDALFQEDSYKKHLKHHCNK---
::::::::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_011 NHSGLSAPVPRGRKGKKVKAQSTQPVVQDADWLASCNPDALFQEDSYKKHLKHHCNNSGN
1690 1700 1710 1720 1730 1740
1740 1750 1760 1770
pF1KE9 ---------------------------VLLRVRMLYYLRQEVIGDQADKILEGADSSEAD
:::::::::::::::::::::::::::::::::
XP_011 NATDQLYVLASCDLEQVIQPLEDSLSWVLLRVRMLYYLRQEVIGDQADKILEGADSSEAD
1750 1760 1770 1780 1790 1800
1780 1790 1800 1810 1820 1830
pF1KE9 VWIPEPFHAEVPADWWDKEADKSLLIGVFKHGYEKYNSMRADPALCFLERVGMPDAKAIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VWIPEPFHAEVPADWWDKEADKSLLIGVFKHGYEKYNSMRADPALCFLERVGMPDAKAIA
1810 1820 1830 1840 1850 1860
1840 1850 1860 1870 1880 1890
pF1KE9 AEQRGTDMLADGGDGGEFDREDEDPEYKPTRTPFKDEIDEFANSPSEDKEESMEIHATGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEQRGTDMLADGGDGGEFDREDEDPEYKPTRTPFKDEIDEFANSPSEDKEESMEIHATGK
1870 1880 1890 1900 1910 1920
1900 1910 1920 1930 1940 1950
pF1KE9 HSESNAELGQLYWPNTSTLTTRLRRLITAYQRSYKRQQMRQEALMKTDRRRRRPREEVRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSESNAELGQLYWPNTSTLTTRLRRLITAYQRSYKRQQMRQEALMKTDRRRRRPREEVRA
1930 1940 1950 1960 1970 1980
1960 1970 1980 1990 2000 2010
pF1KE9 LEAEREAIISEKRQKWTRREEADFYRVVSTFGVIFDPVKQQFDWNQFRAFARLDKKSDES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEAEREAIISEKRQKWTRREEADFYRVVSTFGVIFDPVKQQFDWNQFRAFARLDKKSDES
1990 2000 2010 2020 2030 2040
2020 2030 2040 2050 2060 2070
pF1KE9 LEKYFSCFVAMCRRVCRMPVKPDDEPPDLSSIIEPITEERASRTLYRIELLRKIREQVLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEKYFSCFVAMCRRVCRMPVKPDDEPPDLSSIIEPITEERASRTLYRIELLRKIREQVLH
2050 2060 2070 2080 2090 2100
2080 2090 2100 2110 2120 2130
pF1KE9 HPQLGERLKLCQPSLDLPEWWECGRHDRDLLVGAAKHGVSRTDYHILNDPELSFLDAHKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPQLGERLKLCQPSLDLPEWWECGRHDRDLLVGAAKHGVSRTDYHILNDPELSFLDAHKN
2110 2120 2130 2140 2150 2160
2140 2150 2160 2170 2180 2190
pF1KE9 FAQNRGAGNTSSLNPLAVGFVQTPPVISSAHIQDERVLEQAEGKVEEPENPAAKEKCEGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAQNRGAGNTSSLNPLAVGFVQTPPVISSAHIQDERVLEQAEGKVEEPENPAAKEKCEGK
2170 2180 2190 2200 2210 2220
2200 2210 2220 2230 2240 2250
pF1KE9 EEEEETDGSGKESKQECEAEASSVKNELKGVEVGADTGSKSISEKGSEEDEEEKLEDDDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEEEETDGSGKESKQECEAEASSVKNELKGVEVGADTGSKSISEKGSEEDEEEKLEDDDK
2230 2240 2250 2260 2270 2280
2260 2270 2280 2290 2300 2310
pF1KE9 SEESSQPEAGAVSRGKNFDEESNASMSTARDETRDGFYMEDGDPSVAQLLHERTFAFSFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEESSQPEAGAVSRGKNFDEESNASMSTARDETRDGFYMEDGDPSVAQLLHERTFAFSFW
2290 2300 2310 2320 2330 2340
2320 2330 2340 2350 2360 2370
pF1KE9 PKDRVMINRLDNICEAVLKGKWPVNRRQMFDFQGLIPGYTPTTVDSPLQKRSFAELSMVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PKDRVMINRLDNICEAVLKGKWPVNRRQMFDFQGLIPGYTPTTVDSPLQKRSFAELSMVG
2350 2360 2370 2380 2390 2400
2380 2390 2400 2410 2420 2430
pF1KE9 QASISGSEDITTSPQLSKEDALNLSVPRQRRRRRRKIEIEAERAAKRRNLMEMVAQLRES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QASISGSEDITTSPQLSKEDALNLSVPRQRRRRRRKIEIEAERAAKRRNLMEMVAQLRES
2410 2420 2430 2440 2450 2460
2440 2450 2460 2470 2480 2490
pF1KE9 QVVSENGQEKVVDLSKASREATSSTSNFSSLSSKFILPNVSTPVSDAFKTQMELLQAGLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVVSENGQEKVVDLSKASREATSSTSNFSSLSSKFILPNVSTPVSDAFKTQMELLQAGLS
2470 2480 2490 2500 2510 2520
2500 2510 2520 2530 2540 2550
pF1KE9 RTPTRHLLNGSLVDGEPPMKRRRGRRKNVEGLDLLFMSHKRTSLSAEDAEVTKAFEEDIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTPTRHLLNGSLVDGEPPMKRRRGRRKNVEGLDLLFMSHKRTSLSAEDAEVTKAFEEDIE
2530 2540 2550 2560 2570 2580
2560 2570 2580 2590 2600 2610
pF1KE9 TPPTRNIPSPGQLDPDTRIPVINLEDGTRLVGEDAPKNKDLVEWLKLHPTYTVDMPSYVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPPTRNIPSPGQLDPDTRIPVINLEDGTRLVGEDAPKNKDLVEWLKLHPTYTVDMPSYVP
2590 2600 2610 2620 2630 2640
2620 2630 2640 2650 2660 2670
pF1KE9 KNADVLFSSFQKPKQKRHRCRNPNKLDINTLTGEERVPVVNKRNGKKMGGAMAPPMKDLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNADVLFSSFQKPKQKRHRCRNPNKLDINTLTGEERVPVVNKRNGKKMGGAMAPPMKDLP
2650 2660 2670 2680 2690 2700
2680 2690 2700 2710 2720 2730
pF1KE9 RWLEENPEFAVAPDWTDIVKQSGFVPESMFDRLLTGPVVRGEGASRRGRRPKSEIARAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RWLEENPEFAVAPDWTDIVKQSGFVPESMFDRLLTGPVVRGEGASRRGRRPKSEIARAAA
2710 2720 2730 2740 2750 2760
2740 2750 2760 2770 2780 2790
pF1KE9 AAAAVASTSGINPLLVNSLFAGMDLTSLQNLQNLQSLQLAGLMGFPPGLATAATAGGDAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAAAVASTSGINPLLVNSLFAGMDLTSLQNLQNLQSLQLAGLMGFPPGLATAATAGGDAK
2770 2780 2790 2800 2810 2820
2800 2810 2820 2830 2840 2850
pF1KE9 NPAAVLPLMLPGMAGLPNVFGLGGLLNNPLSAATGNTTTASSQGEPEDSTSKGEEKGNEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPAAVLPLMLPGMAGLPNVFGLGGLLNNPLSAATGNTTTASSQGEPEDSTSKGEEKGNEN
2830 2840 2850 2860 2870 2880
2860 2870 2880 2890 2900 2910
pF1KE9 EDENKDSEKSTDAVSAADSANGSVGAATAPAGLPSNPLAFNPFLLSTMAPGLFYPSMFLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDENKDSEKSTDAVSAADSANGSVGAATAPAGLPSNPLAFNPFLLSTMAPGLFYPSMFLP
2890 2900 2910 2920 2930 2940
2920 2930 2940 2950 2960 2970
pF1KE9 PGLGGLTLPGFPALAGLQNAVGSSEEKAADKAEGGPFKDGETLEGSDAEESLDKTAESSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGLGGLTLPGFPALAGLQNAVGSSEEKAADKAEGGPFKDGETLEGSDAEESLDKTAESSL
2950 2960 2970 2980 2990 3000
2980 2990
pF1KE9 LEDEIAQGEELDSLDGGDEIENNENDE
:::::::::::::::::::::::::::
XP_011 LEDEIAQGEELDSLDGGDEIENNENDE
3010 3020
>>XP_011515862 (OMIM: 189960,214800,608892,612370) PREDI (1621 aa)
initn: 11138 init1: 11138 opt: 11138 Z-score: 4286.9 bits: 807.0 E(85289): 0
Smith-Waterman score: 11138; 100.0% identity (100.0% similar) in 1617 aa overlap (1-1617:1-1617)
10 20 30 40 50 60
pF1KE9 MADPGMMSLFGEDGNIFSEGLEGLGECGYPENPVNPMGQQMPIDQGFASLQPSLHHPSTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MADPGMMSLFGEDGNIFSEGLEGLGECGYPENPVNPMGQQMPIDQGFASLQPSLHHPSTN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 QNQTKLTHFDHYNQYEQQKMHLMDQPNRMMSNTPGNGLASPHSQYHTPPVPQVPHGGSGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QNQTKLTHFDHYNQYEQQKMHLMDQPNRMMSNTPGNGLASPHSQYHTPPVPQVPHGGSGG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 GQMGVYPGMQNERHGQSFVDSSSMWGPRAVQVPDQIRAPYQQQQPQPQPPQPAPSGPPAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQMGVYPGMQNERHGQSFVDSSSMWGPRAVQVPDQIRAPYQQQQPQPQPPQPAPSGPPAQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 GHPQHMQQMGSYMARGDFSMQQHGQPQQRMSQFSQGQEGLNQGNPFIATSGPGHLSHVPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GHPQHMQQMGSYMARGDFSMQQHGQPQQRMSQFSQGQEGLNQGNPFIATSGPGHLSHVPQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 QSPSMAPSLRHSVQQFHHHPSTALHGESVAHSPRFSPNPPQQGAVRPQTLNFSSRSQTVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSPSMAPSLRHSVQQFHHHPSTALHGESVAHSPRFSPNPPQQGAVRPQTLNFSSRSQTVP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 SPTINNSGQYSRYPYSNLNQGLVNNTGMNQNLGLTNNTPMNQSVPRYPNAVGFPSNSGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPTINNSGQYSRYPYSNLNQGLVNNTGMNQNLGLTNNTPMNQSVPRYPNAVGFPSNSGQG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 LMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNPAGTPPPQVRPGSAGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNPAGTPPPQVRPGSAGI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 PMEVGSYPNMPHPQPSHQPPGAMGIGQRNMGPRNMQQSRPFIGMSSAPRELTGHMRPNGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PMEVGSYPNMPHPQPSHQPPGAMGIGQRNMGPRNMQQSRPFIGMSSAPRELTGHMRPNGC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 PGVGLGDPQAIQERLIPGQQHPGQQPSFQQLPTCPPLQPHPGLHHQSSPPHPHHQPWAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGVGLGDPQAIQERLIPGQQHPGQQPSFQQLPTCPPLQPHPGLHHQSSPPHPHHQPWAQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 HPSPQNTPQKVPVHQHSPSEPFLEKPVPDMTQVSGPNAQLVKSDDYLPSIEQQPQQKKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPSPQNTPQKVPVHQHSPSEPFLEKPVPDMTQVSGPNAQLVKSDDYLPSIEQQPQQKKKK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 KKNNHIVAEDPSKGFGKDDFPGGVDNQELNRNSLDGSQEEKKKKKRSKAKKDPKEPKEPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKNNHIVAEDPSKGFGKDDFPGGVDNQELNRNSLDGSQEEKKKKKRSKAKKDPKEPKEPK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 EKKEPKEPKTPKAPKIPKEPKEKKAKTATPKPKSSKKSSNKKPDSEASALKKKVNKGKTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKKEPKEPKTPKAPKIPKEPKEKKAKTATPKPKSSKKSSNKKPDSEASALKKKVNKGKTE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 GSENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE9 DSPSNTSQSEQQESVDAEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSPSNTSQSEQQESVDAEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQW
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE9 ASIEDLEKDKRIQQKIKRFKAKQGQNKFLSEIEDELFNPDYVEVDRIMDFARSTDDRGEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASIEDLEKDKRIQQKIKRFKAKQGQNKFLSEIEDELFNPDYVEVDRIMDFARSTDDRGEP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE9 VTHYLVKWCSLPYEDSTWERRQDIDQAKIEEFEKLMSREPETERVERPPADDWKKSESSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTHYLVKWCSLPYEDSTWERRQDIDQAKIEEFEKLMSREPETERVERPPADDWKKSESSR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE9 EYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE9 VIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAI
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE9 ITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNT
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE9 VEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAP
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE9 KEETIIEVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLING
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEETIIEVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLING
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE9 AEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLD
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE9 ILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADT
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE9 CIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQ
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE9 SMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITI
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE9 ESEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRK
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE9 QTRLYSAVKEDELMEFSDLESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGWGR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTRLYSAVKEDELMEFSDLESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGVNC
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE9 WTDILSHGRYKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRALV
XP_011 C
>>XP_016879216 (OMIM: 616936) PREDICTED: chromodomain-he (2375 aa)
initn: 7270 init1: 3906 opt: 6651 Z-score: 2565.7 bits: 489.1 E(85289): 3.6e-136
Smith-Waterman score: 8544; 56.4% identity (76.5% similar) in 2461 aa overlap (637-2996:14-2368)
610 620 630 640 650 660
pF1KE9 VAEDPSKGFGKDDFPGGVDNQELNRNSLDGSQEEKKKKKRSKAKKDPKEPKEPKEKKEPK
:..:: .. :.: :: : . . .
XP_016 MSEKKQRKKVESESKQEKANRIISEAIAKAKERGERNIPRVMS
10 20 30 40
670 680 690 700 710 720
pF1KE9 EPKTPKAPKIPKEPKEKKAKTATPKPKSSKKSSNKKPDSEASALKKKV-NKGKTEGSENS
. : : :: :. . . :: :.:::... . .: . . : . . :: . .:
XP_016 PENFPTASVEGKEEKKGRRMKSKPKDKDSKKTKTCSKLKEKTKIGKLIITLGKKQKRKNE
50 60 70 80 90 100
730 740 750 760 770 780
pF1KE9 DLDKTPPPSPPPEED-EDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGRDS-P
. :. :.. .: :::::.::.:::.:.::.: : :.::. . ..: :
XP_016 SSDEISDAEQMPQHTLKDQDSQKRRSNRQIKRKKYAEDIEGKQSEEEVKGSMKIKKNSAP
110 120 130 140 150 160
790 800 810 820 830 840
pF1KE9 SNTSQSEQ---QESVDAEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQW
: : .. . .. .:.::.:::.:::. : .. :::.:::::.:::::.:
XP_016 LPGEQPLQLFVENPSEEDAAIVDKILSSRTVKKEISPGVMIDTEEFFVKYKNYSYLHCEW
170 180 190 200 210 220
850 860 870 880 890
pF1KE9 ASIEDLEKDKRIQQKIKRFKAKQGQN-KFLSEIEDELFNPDYVEVDRIMDFARSTD-DRG
:. :.: ::::::::::::: .:.: .:....:.: ::::::::::... . : : :
XP_016 ATEEQLLKDKRIQQKIKRFKLRQAQRAHFFADMEEEPFNPDYVEVDRVLEVSFCEDKDTG
230 240 250 260 270 280
900 910 920 930 940 950
pF1KE9 EPVTHYLVKWCSLPYEDSTWERRQDIDQAKIEEFEKLMSREPETERVERPPADDWKKSES
::: .:::::::::::::::: ..:.: :::::::.:.. .:.:.:..:::.. ::: ..
XP_016 EPVIYYLVKWCSLPYEDSTWELKEDVDLAKIEEFEQLQASRPDTRRLDRPPSNIWKKIDQ
290 300 310 320 330 340
960 970 980 990 1000 1010
pF1KE9 SREYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGIHGP
::.:::.:.::::::::.::::::::: :::::::::::::::::::::::: : ::.::
XP_016 SRDYKNGNQLREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEILLTGIRGP
350 360 370 380 390 400
1020 1030 1040 1050 1060 1070
pF1KE9 FLVIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFH
::.::::::: ::::::::::..:::::::: ::. :: :::::.: :::.:.:.:.:.
XP_016 FLIIAPLSTIANWEREFRTWTDINVVVYHGSLISRQMIQQYEMYFRDSQGRIIRGAYRFQ
410 420 430 440 450 460
1080 1090 1100 1110 1120 1130
pF1KE9 AIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQ
:::::::::: : :: : ::::.:::::::::.:::::::::.:.:::::::::::::
XP_016 AIITTFEMILGGCGELNAIEWRCVIIDEAHRLKNKNCKLLEGLKLMNLEHKVLLTGTPLQ
470 480 490 500 510 520
1140 1150 1160 1170 1180 1190
pF1KE9 NTVEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNL
::::::::::::::: :::::.::::::::::::::::::::::::::::::::::::.:
XP_016 NTVEELFSLLHFLEPLRFPSESTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKKL
530 540 550 560 570 580
1200 1210 1220 1230 1240 1250
pF1KE9 APKEETIIEVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLI
::::::::::::::::::::::::::::.:::::.::.:::::.::::::::::::::::
XP_016 APKEETIIEVELTNIQKKYYRAILEKNFSFLSKGAGQTNVPNLVNTMMELRKCCNHPYLI
590 600 610 620 630 640
1260 1270 1280 1290 1300 1310
pF1KE9 NGAEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRC
.::::::: ::..:.: . ::.::::::.:::::::::::::.:::::.::::::::::
XP_016 KGAEEKILGEFRDTYNPAASDFHLQAMIQSAGKLVLIDKLLPKMKAGGHKVLIFSQMVRC
650 660 670 680 690 700
1320 1330 1340 1350 1360 1370
pF1KE9 LDILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAA
:::::::::..:: ::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDILEDYLIHKRYLYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAA
710 720 730 740 750 760
1380 1390 1400 1410 1420 1430
pF1KE9 DTCIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAV
:::::::::::::::::::::::::::.:.::.:::.:::::::::::.:::::::::::
XP_016 DTCIIFDSDWNPQNDLQAQARCHRIGQNKAVKVYRLVTRNSYEREMFDRASLKLGLDKAV
770 780 790 800 810 820
1440 1450 1460 1470 1480 1490
pF1KE9 LQSMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTI
::::::::. ..:.:::::::::::::.:::::.:.:::::::::::::::::::::.::
XP_016 LQSMSGRESNVGGIQQLSKKEIEDLLRRGAYGAIMEEEDEGSKFCEEDIDQILLRRTKTI
830 840 850 860 870 880
1500 1510 1520 1530 1540 1550
pF1KE9 TIESEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRV
::::::.::::::::::::::::::::::::::::::::::.::.:..:::.:::::::.
XP_016 TIESEGRGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAEIDIEAISGRNSLVIDTPRI
890 900 910 920 930 940
1560 1570 1580 1590 1600 1610
pF1KE9 RKQTRLYSAVKEDELMEFSDLESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGW
::::: .::.: ::: :.:. ::...::: : ::: :.:.::.:.::::::::::::::
XP_016 RKQTRPFSATK-DELAELSEAESEGDEKP--KLRRPCDRSNGYGRTECFRVEKNLLVYGW
950 960 970 980 990 1000
1620 1630 1640 1650 1660 1670
pF1KE9 GRWTDILSHGRYKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRA
::: .::::::.::::.:.::: :::..:.::: ::.:::.::.::::::::: :::::
XP_016 GRWREILSHGRFKRQLNEHDVEIICRALLAYCLVHYRGDEKIKGFIWDLITPTEDGQTRE
1010 1020 1030 1040 1050 1060
1680 1690 1700 1710 1720 1730
pF1KE9 LVNHSGLSAPVPRGRKGKKVKAQSTQPVVQDADWLASCNPDALFQEDSYKKHLKHHCNKV
: :: ::::::::::::::::.:... .: :.:: . ::. :.:...::::.:::::::
XP_016 LQNHLGLSAPVPRGRKGKKVKTQTSSFDIQKAEWLRKYNPEQLLQDEGYKKHIKHHCNKV
1070 1080 1090 1100 1110 1120
1740 1750 1760 1770 1780 1790
pF1KE9 LLRVRMLYYLRQEVIGDQADKILEGADSSEADVWIPEPFHAEVPADWWDKEADKSLLIGV
::::::::::.:::::.. .:...:.:.:. :::.::: :.::::.::: .:::::::::
XP_016 LLRVRMLYYLKQEVIGNECQKVFDGVDASDIDVWVPEPDHSEVPAEWWDFDADKSLLIGV
1130 1140 1150 1160 1170 1180
1800 1810 1820 1830 1840 1850
pF1KE9 FKHGYEKYNSMRADPALCFLERVGMPDAKAIAAEQRGTDMLADGGDGGEFDREDEDPEYK
:::::::::..::::::::::::: :: ::.:::::..:.. :: . ::::::
XP_016 FKHGYEKYNTIRADPALCFLERVGKPDEKAVAAEQRANDYM----DG-----DVEDPEYK
1190 1200 1210 1220 1230
1860 1870 1880 1890 1900 1910
pF1KE9 PTRTPFKDEIDEFANSPSEDKEESMEIHATGKHSESNAELGQLYWPNTSTLTTRLRRLIT
:. . :::.:.. ..::.. . . :. :.. ..:::. :.::::::::::
XP_016 PAPAIFKDDIEDDVSSPGD----LVIADGDGQLMEGD----KVYWPTQSALTTRLRRLIT
1240 1250 1260 1270 1280
1920 1930 1940 1950 1960 1970
pF1KE9 AYQRSYKRQQMRQ-EALMKTDRRRRRPREEVRALEAEREAIISEKRQKWTRREEADFYRV
::::. : .:..: . ... .: : .:. . : : :..:.::::::::::::
XP_016 AYQRTNKNRQIQQIQPTFSVPTSVMQPIYEEATLNPKMAAKI-ERQQRWTRREEADFYRV
1290 1300 1310 1320 1330 1340
1980 1990 2000 2010 2020 2030
pF1KE9 VSTFGVIFDPVKQQFDWNQFRAFARLDKKSDESLEKYFSCFVAMCRRVCRMPVKPDDEPP
::::::.::: . ::::..:::.::: ::.:.:::::. :..:::::::.: : . :
XP_016 VSTFGVVFDPDRGQFDWTKFRAMARLHKKTDDSLEKYLYAFMSMCRRVCRLPSKEELVDP
1350 1360 1370 1380 1390 1400
2040 2050 2060 2070 2080 2090
pF1KE9 DLSSIIEPITEERASRTLYRIELLRKIREQVLHHPQLGERLKLCQPSLDLPEWWECGRHD
.. .:.:::::::::::::::::::.:::.:.:::: ::::::.:. ::: ::::: ::
XP_016 NI--FIQPITEERASRTLYRIELLRKVREQALRHPQLFERLKLCHPNPDLPVWWECGPHD
1410 1420 1430 1440 1450 1460
2100 2110 2120 2130 2140
pF1KE9 RDLLVGAAKHGVSRTDYHILNDPELSFLDAHKNFAQNRGAGNTSSL------------NP
::::.::::::::::::::: ::::::. :..:..:.. : . .: .:
XP_016 RDLLIGAAKHGVSRTDYHILRDPELSFMAAQRNYSQSKMAHSRTSTPLLQQYQVALSASP
1470 1480 1490 1500 1510 1520
2150 2160 2170
pF1KE9 L--------AVGFVQTPPVISSAHIQDE--------------RVLEQAE-----------
: : :.. ..: ....: :.: ..:
XP_016 LTSLPRLLDAKGIILEEMKVKSENLKEEPQSSEEESMSSVETRTLIKSEPVSPKNGVLPQ
1530 1540 1550 1560 1570 1580
2180 2190 2200
pF1KE9 --------GKVE----------EP--ENPAAKE---KCEGKEEEEETDGSGKESKQECEA
:: : :: :::.:. . .:.: ..:.....:. ..
XP_016 ATGDQKSGGKCETDRRMVAARTEPLTPNPASKKPRVHKRGSESSSDSDSDSERSSCSSRS
1590 1600 1610 1620 1630 1640
2210 2220 2230 2240 2250
pF1KE9 EASSVKNELKGVEVGADTGSKSI----------SEKGSEEDEEEKLEDDDKSEESSQPEA
.:: .. . . :....:.: : ..: . . :..:..:: .: .:
XP_016 SSSSSSSSCSHSRSGSSSSSSSSCSSASSSSSSSTSSSSSSSSSSSEESDSDEEEAQKRA
1650 1660 1670 1680 1690 1700
2260 2270 2280 2290 2300 2310
pF1KE9 GAVSRGKNFDEESNASMSTARDETRDGFYMEDGDPSVAQLLHE-RTFAFSFWPKDRVMIN
.... : .:::: ::.::..:::.:.: :..: : : .:. .: :.:::::::::
XP_016 ESTTHMKAYDEESVASLSTTQDETQDSFQMNNGTPESAYILQGGYMLAASYWPKDRVMIN
1710 1720 1730 1740 1750 1760
2320 2330 2340 2350 2360 2370
pF1KE9 RLDNICEAVLKGKWPVNRRQMFDFQGLIPGYTPTTVDSPLQKRSFAELSMVGQASISGSE
:::.::..::::::: ::. .: . . :: .::: ... :. . . .:
XP_016 RLDSICQTVLKGKWPSARRS-YDANTVASFYTTKLLDSPGAATEYSDPSVPTPPGAGVKE
1770 1780 1790 1800 1810
2380 2390 2400 2410 2420 2430
pF1KE9 DITTSPQLSKEDALNLSVPRQRRRRRRKIEIEAERAAKRRNLMEMVAQLRESQVVSENGQ
. : :.::: .:.:. .: ..: .. : .... : ..::: : .::
XP_016 EHDQSTQMSKEGGLKLTFQKQGLAQKRPFDGEDGALGQQQYL----TRLRELQSASE---
1820 1830 1840 1850 1860 1870
2440 2450 2460 2470 2480 2490
pF1KE9 EKVVDLSKASREATSSTSNFSSLSSKFILPNVSTPVSDAFKTQMELLQAGLSRTPTRHLL
.: :: :. : ::: : : ::
XP_016 --------------TSLVNF---------PK-SIPVS------------GTSIQPTLGA-
1880 1890
2500 2510 2520 2530 2540 2550
pF1KE9 NGSLVDGEPPMKRRRGRRKNVEGLDLLFMSHKR----TSLSAEDAEVTKAFEEDIETPPT
:: ..:..: .:.::::::::::.:..:..... .::. ..... ... .
XP_016 NGVILDNQPIVKKRRGRRKNVEGVDIFFFNRNKPPNHVSLGLTSSQISTGINPALSYTQP
1900 1910 1920 1930 1940 1950
2560 2570 2580 2590 2600 2610
pF1KE9 RNIPSPGQLDPDTRIPVINLEDGTRLVGEDAPKNKDLVEWLKLHPTYTVDMPSYVPKNAD
..:: : .. .:::::.:::::.:.:::: ::: .::: :: :. :. ...:.
XP_016 QGIP-----DTESPVPVINLKDGTRLAGDDAPKRKDLEKWLKEHPGYVEDLGAFIPR---
1960 1970 1980 1990 2000
2620 2630 2640 2650 2660 2670
pF1KE9 VLFSSFQKPKQKRHRCRNPNKLDINTLTGEERVPVVNKRNGKKMGGAMAPPMKDLPRWLE
. .:::::::::::::::.:.::::::: ..:.::..:.:::.:::.::: :.:.
XP_016 -MQLHEGRPKQKRHRCRNPNKLDVNSLTGEERVQLINRRNARKVGGAFAPPLKDLCRFLK
2010 2020 2030 2040 2050 2060
2680 2690 2700 2710 2720 2730
pF1KE9 ENPEFAVAPDWTDIVKQSGFVPESMFDRLLTGPVVRGEGASRRGRRPKSEIARAAAAAAA
:: :..:::.: :.::::::.::::..:.::::::: : .::::::::: ::.:.:::::
XP_016 ENSEYGVAPEWGDVVKQSGFLPESMYERILTGPVVREE-VSRRGRRPKSGIAKATAAAAA
2070 2080 2090 2100 2110 2120
2740 2750 2760 2770 2780
pF1KE9 VASTS-GINPLLVNSLFAGMDLTSLQ----NLQNLQSLQL-AGLMGFPPGLATAATAGGD
...:: . ::::.:.:. :.:::.:: :::::::::. :::::.: :: . ::.
XP_016 ASATSVSGNPLLANGLLPGVDLTTLQALQQNLQNLQSLQVTAGLMGMPTGLPS----GGE
2130 2140 2150 2160 2170 2180
2790 2800 2810 2820 2830 2840
pF1KE9 AKNPAAVLPLMLPGMAGLPNVFGLGGLLNNPLSAATGNTTTASSQGEPEDSTSKGEEKGN
::: ::..:..: :::::::..:.::::..: ..: . ..:. : : .: . : ...
XP_016 AKNMAAMFPMLLSGMAGLPNLLGMGGLLTKPTESGTEDKKGSDSK-ESEGKTERTESQSS
2190 2200 2210 2220 2230 2240
2850 2860 2870 2880 2890 2900
pF1KE9 ENEDENKDSEKSTDAVSAADSANGSVGAATAPAGLPSNPLAFNPFLLSTMAPGLFYPSMF
:: :: .::.. :...... :: : .::::.::.:::.. .::.:.
XP_016 ENGGEN--------SVSSSPSTSSTAALNTAAA---ANPLALNPLLLSNI----LYPGML
2250 2260 2270 2280
2910 2920 2930 2940 2950 2960
pF1KE9 LPPGLGGLTLPGFPALAGLQNAVGSSEEKAADKAEGGPFKDGETLEGSDAEESLDK--TA
: :::. : .: . :. . . ..: .: . . . : : : ... :: :
XP_016 LTPGLN-LHIPTLS-----QSNTFDVQNKNSDLGSSKSVEVKE--EDSRIKDQEDKGGTE
2290 2300 2310 2320 2330
2970 2980 2990
pF1KE9 ESSLLEDEIAQG-EELDSLDGGDEIENNENDE
: : :. .: :. :. .:.: .. .:
XP_016 PSPLNENSTDEGSEKADASSGSDSTSSSSEDSDSSNED
2340 2350 2360 2370
>>XP_016879214 (OMIM: 616936) PREDICTED: chromodomain-he (2431 aa)
initn: 7270 init1: 3906 opt: 6651 Z-score: 2565.5 bits: 489.1 E(85289): 3.7e-136
Smith-Waterman score: 8544; 56.4% identity (76.5% similar) in 2461 aa overlap (637-2996:70-2424)
610 620 630 640 650 660
pF1KE9 VAEDPSKGFGKDDFPGGVDNQELNRNSLDGSQEEKKKKKRSKAKKDPKEPKEPKEKKEPK
:..:: .. :.: :: : . . .
XP_016 SDGSGTYTKLQNTQVRVMSEKKQRKKVESESKQEKANRIISEAIAKAKERGERNIPRVMS
40 50 60 70 80 90
670 680 690 700 710 720
pF1KE9 EPKTPKAPKIPKEPKEKKAKTATPKPKSSKKSSNKKPDSEASALKKKV-NKGKTEGSENS
. : : :: :. . . :: :.:::... . .: . . : . . :: . .:
XP_016 PENFPTASVEGKEEKKGRRMKSKPKDKDSKKTKTCSKLKEKTKIGKLIITLGKKQKRKNE
100 110 120 130 140 150
730 740 750 760 770 780
pF1KE9 DLDKTPPPSPPPEED-EDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGRDS-P
. :. :.. .: :::::.::.:::.:.::.: : :.::. . ..: :
XP_016 SSDEISDAEQMPQHTLKDQDSQKRRSNRQIKRKKYAEDIEGKQSEEEVKGSMKIKKNSAP
160 170 180 190 200 210
790 800 810 820 830 840
pF1KE9 SNTSQSEQ---QESVDAEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQW
: : .. . .. .:.::.:::.:::. : .. :::.:::::.:::::.:
XP_016 LPGEQPLQLFVENPSEEDAAIVDKILSSRTVKKEISPGVMIDTEEFFVKYKNYSYLHCEW
220 230 240 250 260 270
850 860 870 880 890
pF1KE9 ASIEDLEKDKRIQQKIKRFKAKQGQN-KFLSEIEDELFNPDYVEVDRIMDFARSTD-DRG
:. :.: ::::::::::::: .:.: .:....:.: ::::::::::... . : : :
XP_016 ATEEQLLKDKRIQQKIKRFKLRQAQRAHFFADMEEEPFNPDYVEVDRVLEVSFCEDKDTG
280 290 300 310 320 330
900 910 920 930 940 950
pF1KE9 EPVTHYLVKWCSLPYEDSTWERRQDIDQAKIEEFEKLMSREPETERVERPPADDWKKSES
::: .:::::::::::::::: ..:.: :::::::.:.. .:.:.:..:::.. ::: ..
XP_016 EPVIYYLVKWCSLPYEDSTWELKEDVDLAKIEEFEQLQASRPDTRRLDRPPSNIWKKIDQ
340 350 360 370 380 390
960 970 980 990 1000 1010
pF1KE9 SREYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGIHGP
::.:::.:.::::::::.::::::::: :::::::::::::::::::::::: : ::.::
XP_016 SRDYKNGNQLREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEILLTGIRGP
400 410 420 430 440 450
1020 1030 1040 1050 1060 1070
pF1KE9 FLVIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFH
::.::::::: ::::::::::..:::::::: ::. :: :::::.: :::.:.:.:.:.
XP_016 FLIIAPLSTIANWEREFRTWTDINVVVYHGSLISRQMIQQYEMYFRDSQGRIIRGAYRFQ
460 470 480 490 500 510
1080 1090 1100 1110 1120 1130
pF1KE9 AIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQ
:::::::::: : :: : ::::.:::::::::.:::::::::.:.:::::::::::::
XP_016 AIITTFEMILGGCGELNAIEWRCVIIDEAHRLKNKNCKLLEGLKLMNLEHKVLLTGTPLQ
520 530 540 550 560 570
1140 1150 1160 1170 1180 1190
pF1KE9 NTVEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNL
::::::::::::::: :::::.::::::::::::::::::::::::::::::::::::.:
XP_016 NTVEELFSLLHFLEPLRFPSESTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKKL
580 590 600 610 620 630
1200 1210 1220 1230 1240 1250
pF1KE9 APKEETIIEVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLI
::::::::::::::::::::::::::::.:::::.::.:::::.::::::::::::::::
XP_016 APKEETIIEVELTNIQKKYYRAILEKNFSFLSKGAGQTNVPNLVNTMMELRKCCNHPYLI
640 650 660 670 680 690
1260 1270 1280 1290 1300 1310
pF1KE9 NGAEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRC
.::::::: ::..:.: . ::.::::::.:::::::::::::.:::::.::::::::::
XP_016 KGAEEKILGEFRDTYNPAASDFHLQAMIQSAGKLVLIDKLLPKMKAGGHKVLIFSQMVRC
700 710 720 730 740 750
1320 1330 1340 1350 1360 1370
pF1KE9 LDILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAA
:::::::::..:: ::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDILEDYLIHKRYLYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAA
760 770 780 790 800 810
1380 1390 1400 1410 1420 1430
pF1KE9 DTCIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAV
:::::::::::::::::::::::::::.:.::.:::.:::::::::::.:::::::::::
XP_016 DTCIIFDSDWNPQNDLQAQARCHRIGQNKAVKVYRLVTRNSYEREMFDRASLKLGLDKAV
820 830 840 850 860 870
1440 1450 1460 1470 1480 1490
pF1KE9 LQSMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTI
::::::::. ..:.:::::::::::::.:::::.:.:::::::::::::::::::::.::
XP_016 LQSMSGRESNVGGIQQLSKKEIEDLLRRGAYGAIMEEEDEGSKFCEEDIDQILLRRTKTI
880 890 900 910 920 930
1500 1510 1520 1530 1540 1550
pF1KE9 TIESEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRV
::::::.::::::::::::::::::::::::::::::::::.::.:..:::.:::::::.
XP_016 TIESEGRGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAEIDIEAISGRNSLVIDTPRI
940 950 960 970 980 990
1560 1570 1580 1590 1600 1610
pF1KE9 RKQTRLYSAVKEDELMEFSDLESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGW
::::: .::.: ::: :.:. ::...::: : ::: :.:.::.:.::::::::::::::
XP_016 RKQTRPFSATK-DELAELSEAESEGDEKP--KLRRPCDRSNGYGRTECFRVEKNLLVYGW
1000 1010 1020 1030 1040 1050
1620 1630 1640 1650 1660 1670
pF1KE9 GRWTDILSHGRYKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRA
::: .::::::.::::.:.::: :::..:.::: ::.:::.::.::::::::: :::::
XP_016 GRWREILSHGRFKRQLNEHDVEIICRALLAYCLVHYRGDEKIKGFIWDLITPTEDGQTRE
1060 1070 1080 1090 1100 1110
1680 1690 1700 1710 1720 1730
pF1KE9 LVNHSGLSAPVPRGRKGKKVKAQSTQPVVQDADWLASCNPDALFQEDSYKKHLKHHCNKV
: :: ::::::::::::::::.:... .: :.:: . ::. :.:...::::.:::::::
XP_016 LQNHLGLSAPVPRGRKGKKVKTQTSSFDIQKAEWLRKYNPEQLLQDEGYKKHIKHHCNKV
1120 1130 1140 1150 1160 1170
1740 1750 1760 1770 1780 1790
pF1KE9 LLRVRMLYYLRQEVIGDQADKILEGADSSEADVWIPEPFHAEVPADWWDKEADKSLLIGV
::::::::::.:::::.. .:...:.:.:. :::.::: :.::::.::: .:::::::::
XP_016 LLRVRMLYYLKQEVIGNECQKVFDGVDASDIDVWVPEPDHSEVPAEWWDFDADKSLLIGV
1180 1190 1200 1210 1220 1230
1800 1810 1820 1830 1840 1850
pF1KE9 FKHGYEKYNSMRADPALCFLERVGMPDAKAIAAEQRGTDMLADGGDGGEFDREDEDPEYK
:::::::::..::::::::::::: :: ::.:::::..:.. :: . ::::::
XP_016 FKHGYEKYNTIRADPALCFLERVGKPDEKAVAAEQRANDYM----DG-----DVEDPEYK
1240 1250 1260 1270 1280
1860 1870 1880 1890 1900 1910
pF1KE9 PTRTPFKDEIDEFANSPSEDKEESMEIHATGKHSESNAELGQLYWPNTSTLTTRLRRLIT
:. . :::.:.. ..::.. . . :. :.. ..:::. :.::::::::::
XP_016 PAPAIFKDDIEDDVSSPGD----LVIADGDGQLMEGD----KVYWPTQSALTTRLRRLIT
1290 1300 1310 1320 1330
1920 1930 1940 1950 1960 1970
pF1KE9 AYQRSYKRQQMRQ-EALMKTDRRRRRPREEVRALEAEREAIISEKRQKWTRREEADFYRV
::::. : .:..: . ... .: : .:. . : : :..:.::::::::::::
XP_016 AYQRTNKNRQIQQIQPTFSVPTSVMQPIYEEATLNPKMAAKI-ERQQRWTRREEADFYRV
1340 1350 1360 1370 1380 1390
1980 1990 2000 2010 2020 2030
pF1KE9 VSTFGVIFDPVKQQFDWNQFRAFARLDKKSDESLEKYFSCFVAMCRRVCRMPVKPDDEPP
::::::.::: . ::::..:::.::: ::.:.:::::. :..:::::::.: : . :
XP_016 VSTFGVVFDPDRGQFDWTKFRAMARLHKKTDDSLEKYLYAFMSMCRRVCRLPSKEELVDP
1400 1410 1420 1430 1440 1450
2040 2050 2060 2070 2080 2090
pF1KE9 DLSSIIEPITEERASRTLYRIELLRKIREQVLHHPQLGERLKLCQPSLDLPEWWECGRHD
.. .:.:::::::::::::::::::.:::.:.:::: ::::::.:. ::: ::::: ::
XP_016 NI--FIQPITEERASRTLYRIELLRKVREQALRHPQLFERLKLCHPNPDLPVWWECGPHD
1460 1470 1480 1490 1500 1510
2100 2110 2120 2130 2140
pF1KE9 RDLLVGAAKHGVSRTDYHILNDPELSFLDAHKNFAQNRGAGNTSSL------------NP
::::.::::::::::::::: ::::::. :..:..:.. : . .: .:
XP_016 RDLLIGAAKHGVSRTDYHILRDPELSFMAAQRNYSQSKMAHSRTSTPLLQQYQVALSASP
1520 1530 1540 1550 1560 1570
2150 2160 2170
pF1KE9 L--------AVGFVQTPPVISSAHIQDE--------------RVLEQAE-----------
: : :.. ..: ....: :.: ..:
XP_016 LTSLPRLLDAKGIILEEMKVKSENLKEEPQSSEEESMSSVETRTLIKSEPVSPKNGVLPQ
1580 1590 1600 1610 1620 1630
2180 2190 2200
pF1KE9 --------GKVE----------EP--ENPAAKE---KCEGKEEEEETDGSGKESKQECEA
:: : :: :::.:. . .:.: ..:.....:. ..
XP_016 ATGDQKSGGKCETDRRMVAARTEPLTPNPASKKPRVHKRGSESSSDSDSDSERSSCSSRS
1640 1650 1660 1670 1680 1690
2210 2220 2230 2240 2250
pF1KE9 EASSVKNELKGVEVGADTGSKSI----------SEKGSEEDEEEKLEDDDKSEESSQPEA
.:: .. . . :....:.: : ..: . . :..:..:: .: .:
XP_016 SSSSSSSSCSHSRSGSSSSSSSSCSSASSSSSSSTSSSSSSSSSSSEESDSDEEEAQKRA
1700 1710 1720 1730 1740 1750
2260 2270 2280 2290 2300 2310
pF1KE9 GAVSRGKNFDEESNASMSTARDETRDGFYMEDGDPSVAQLLHE-RTFAFSFWPKDRVMIN
.... : .:::: ::.::..:::.:.: :..: : : .:. .: :.:::::::::
XP_016 ESTTHMKAYDEESVASLSTTQDETQDSFQMNNGTPESAYILQGGYMLAASYWPKDRVMIN
1760 1770 1780 1790 1800 1810
2320 2330 2340 2350 2360 2370
pF1KE9 RLDNICEAVLKGKWPVNRRQMFDFQGLIPGYTPTTVDSPLQKRSFAELSMVGQASISGSE
:::.::..::::::: ::. .: . . :: .::: ... :. . . .:
XP_016 RLDSICQTVLKGKWPSARRS-YDANTVASFYTTKLLDSPGAATEYSDPSVPTPPGAGVKE
1820 1830 1840 1850 1860 1870
2380 2390 2400 2410 2420 2430
pF1KE9 DITTSPQLSKEDALNLSVPRQRRRRRRKIEIEAERAAKRRNLMEMVAQLRESQVVSENGQ
. : :.::: .:.:. .: ..: .. : .... : ..::: : .::
XP_016 EHDQSTQMSKEGGLKLTFQKQGLAQKRPFDGEDGALGQQQYL----TRLRELQSASE---
1880 1890 1900 1910 1920
2440 2450 2460 2470 2480 2490
pF1KE9 EKVVDLSKASREATSSTSNFSSLSSKFILPNVSTPVSDAFKTQMELLQAGLSRTPTRHLL
.: :: :. : ::: : : ::
XP_016 --------------TSLVNF---------PK-SIPVS------------GTSIQPTLGA-
1930 1940 1950
2500 2510 2520 2530 2540 2550
pF1KE9 NGSLVDGEPPMKRRRGRRKNVEGLDLLFMSHKR----TSLSAEDAEVTKAFEEDIETPPT
:: ..:..: .:.::::::::::.:..:..... .::. ..... ... .
XP_016 NGVILDNQPIVKKRRGRRKNVEGVDIFFFNRNKPPNHVSLGLTSSQISTGINPALSYTQP
1960 1970 1980 1990 2000 2010
2560 2570 2580 2590 2600 2610
pF1KE9 RNIPSPGQLDPDTRIPVINLEDGTRLVGEDAPKNKDLVEWLKLHPTYTVDMPSYVPKNAD
..:: : .. .:::::.:::::.:.:::: ::: .::: :: :. :. ...:.
XP_016 QGIP-----DTESPVPVINLKDGTRLAGDDAPKRKDLEKWLKEHPGYVEDLGAFIPR---
2020 2030 2040 2050 2060
2620 2630 2640 2650 2660 2670
pF1KE9 VLFSSFQKPKQKRHRCRNPNKLDINTLTGEERVPVVNKRNGKKMGGAMAPPMKDLPRWLE
. .:::::::::::::::.:.::::::: ..:.::..:.:::.:::.::: :.:.
XP_016 -MQLHEGRPKQKRHRCRNPNKLDVNSLTGEERVQLINRRNARKVGGAFAPPLKDLCRFLK
2070 2080 2090 2100 2110 2120
2680 2690 2700 2710 2720 2730
pF1KE9 ENPEFAVAPDWTDIVKQSGFVPESMFDRLLTGPVVRGEGASRRGRRPKSEIARAAAAAAA
:: :..:::.: :.::::::.::::..:.::::::: : .::::::::: ::.:.:::::
XP_016 ENSEYGVAPEWGDVVKQSGFLPESMYERILTGPVVREE-VSRRGRRPKSGIAKATAAAAA
2130 2140 2150 2160 2170 2180
2740 2750 2760 2770 2780
pF1KE9 VASTS-GINPLLVNSLFAGMDLTSLQ----NLQNLQSLQL-AGLMGFPPGLATAATAGGD
...:: . ::::.:.:. :.:::.:: :::::::::. :::::.: :: . ::.
XP_016 ASATSVSGNPLLANGLLPGVDLTTLQALQQNLQNLQSLQVTAGLMGMPTGLPS----GGE
2190 2200 2210 2220 2230
2790 2800 2810 2820 2830 2840
pF1KE9 AKNPAAVLPLMLPGMAGLPNVFGLGGLLNNPLSAATGNTTTASSQGEPEDSTSKGEEKGN
::: ::..:..: :::::::..:.::::..: ..: . ..:. : : .: . : ...
XP_016 AKNMAAMFPMLLSGMAGLPNLLGMGGLLTKPTESGTEDKKGSDSK-ESEGKTERTESQSS
2240 2250 2260 2270 2280 2290
2850 2860 2870 2880 2890 2900
pF1KE9 ENEDENKDSEKSTDAVSAADSANGSVGAATAPAGLPSNPLAFNPFLLSTMAPGLFYPSMF
:: :: .::.. :...... :: : .::::.::.:::.. .::.:.
XP_016 ENGGEN--------SVSSSPSTSSTAALNTAAA---ANPLALNPLLLSNI----LYPGML
2300 2310 2320 2330 2340
2910 2920 2930 2940 2950 2960
pF1KE9 LPPGLGGLTLPGFPALAGLQNAVGSSEEKAADKAEGGPFKDGETLEGSDAEESLDK--TA
: :::. : .: . :. . . ..: .: . . . : : : ... :: :
XP_016 LTPGLN-LHIPTLS-----QSNTFDVQNKNSDLGSSKSVEVKE--EDSRIKDQEDKGGTE
2350 2360 2370 2380 2390
2970 2980 2990
pF1KE9 ESSLLEDEIAQG-EELDSLDGGDEIENNENDE
: : :. .: :. :. .:.: .. .:
XP_016 PSPLNENSTDEGSEKADASSGSDSTSSSSEDSDSSNED
2400 2410 2420 2430
>>XP_016879211 (OMIM: 616936) PREDICTED: chromodomain-he (2882 aa)
initn: 7270 init1: 3906 opt: 6651 Z-score: 2564.5 bits: 489.1 E(85289): 4.2e-136
Smith-Waterman score: 8945; 49.5% identity (71.4% similar) in 3123 aa overlap (1-2996:1-2875)
10 20 30 40 50
pF1KE9 MADPGMMSLFGEDGNIFSEGLEGLGECGYPE-NPVNPMGQQMPIDQGFASLQ-PSLHHPS
:.:: ::..: .:.:.:.: ::::.. .. . .::. . ... . : :. ::.: .
XP_016 MTDP-MMDFF-DDANLFGETLEGLSDDAFVQPGPVS-LVDELNLGAEFEPLHIDSLNHVQ
10 20 30 40 50
60 70 80 90 100 110
pF1KE9 TNQNQTKLTHFDHYNQYEQQKMHLMDQPNRMMSNTPGNGLASPHSQYHTPPV-PQVPHGG
. .. :.: :.. ::... :.: ..: ..:.. . :::::.. :. ::
XP_016 GTPTHQKMTDFEQLNQFDSIKFHHVNQS----FGSPAEHVLSPHSQFNCSPIHPQ-----
60 70 80 90 100
120 130 140 150 160 170
pF1KE9 SGGGQMGVYPGMQNERHGQSFVDSSSMWGPR-AVQVPDQIRAPYQQQQPQPQPPQPAPSG
. :..: .. :.: ::: . :. . .: .:..::
XP_016 --NQPNGLFPDVS---------DGSPMWGHQTATTISNQNGSPFHQQ-------------
110 120 130 140
180 190 200 210 220
pF1KE9 PPAQGHPQHMQQMGSYMARGDFSM----QQHGQ-----PQQRMSQFSQGQEGLNQGNPFI
:: . :.: :..:. ::.. .:. : :: .... ::..:.:.. :.
XP_016 ----GHSHSMHQNKSFVAHHDFALFQANEQQTQCTSLRSQQNRNNLNPGQNSLSQSKNFM
150 160 170 180 190 200
230 240 250 260 270 280
pF1KE9 ATSGPG--HLSHVPQQSPSMAPSLRHSVQQFHH--HPSTALHGESVAHSPRFSPNPPQQG
.::: ...: ::.. . . :.::: . .::. .: : .: :.:
XP_016 NVSGPHRVNVNHPPQMTNASNSQQSISMQQFSQTSNPSAHFHKCS-SH---------QEG
210 220 230 240 250
290 300 310 320 330 340
pF1KE9 AVRPQTLNFSSRSQTVPSPTINNSGQYSRYPYSNLNQGLVNNTGMNQNLGLTNNTPMNQS
::.. : .. : ...:: :.: . :: .... .. ... :. .. .. ::.
XP_016 -------NFNGPSPNMTSCSVSNSQQFSSH-YS-FSSNHISPNSLLQSSAVLASNHTNQT
260 270 280 290 300
350 360 370 380 390 400
pF1KE9 VPRYPNAVGFPSNSG-QGLMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAM
. . .. .: . : . :. ..:. :::. : : .: :.:::.: : .::.. :
XP_016 LSDFTGSNSFSPHRGIKQESTQHILNPNTSLNSNNFQILHSSHPQGNY-SNSKLSPVH-M
310 320 330 340 350
410 420 430 440 450 460
pF1KE9 SNPAGTPPPQVRPGSAGIPMEVGSYPNMPHPQPSHQPPGAMGIGQRNMGPRNMQQSRPFI
. : :.. :. .: : . .: .... ..:. . .:..::
XP_016 NFPD--------------PVDSGT--QMGHFN-DHVETNGFSSLEENLLHQVESQTEPFT
360 370 380 390 400
470 480 490 500 510 520
pF1KE9 GMSSAPRELTGHMRPNGCPGVGLGDPQAIQERLIP--GQQHPGQQPSFQQLPTCPPLQPH
:.. :..: .:: :.: .. ::. : . : :
XP_016 GLD--PEDL-------------------LQEGLLPHFDESTFGQDNSSHILDHDLDRQF-
410 420 430 440
530 540 550 560 570 580
pF1KE9 PGLHHQSSPPHPHHQPWAQLHPSPQNTPQKVPVHQHSPSEPFLEKPVPDMTQVSGPNAQL
: . : : : . .. . : :. .. :.. :. . .: ..
XP_016 --TSHLVTRPSDMAQTQLQSQARSWHSSFSNHQHLHDRNHLCLQRQPPSSKKSDGSGTYT
450 460 470 480 490
590 600 610 620 630
pF1KE9 VKSDDYLPSIEQQPQQKK-----KKKKNNHIVAEDPSKG--FGKDDFPGGVDNQELNRNS
.. . . .. :.:: :..: :.:..: .:. :. ..: .. ... :
XP_016 KLQNTQVRVMSEKKQRKKVESESKQEKANRIISEAIAKAKERGERNIPRVMSPENFPTAS
500 510 520 530 540 550
640 650 660 670 680 690
pF1KE9 LDGSQEEKKKKKRSKAKKDPKEPKEPKEKKEPKEPKTPKAPKIPKEPKEKKAKTATPKPK
..:..:.: .. .:: ::. ::.::
XP_016 VEGKEEKKGRRMKSK----------------------------PKDKDSKKTKTC-----
560 570 580
700 710 720 730 740 750
pF1KE9 SSKKSSNKKPDSEASALKKKVNKGKTEGS-ENSDLDKTPPPSPPPEEDEDPGVQKRRSSR
:: . . : . .: :: .: :.:.: : :: .. : . .:.: :::::.:
XP_016 -SKLKEKTKIGKLIITLGKK-QKRKNESSDEISDAEQMPQHT---LKDQDS--QKRRSNR
590 600 610 620 630
760 770 780 790 800
pF1KE9 QVKRKRYTEDLEFKISDEEADDADAAGRDS-PSNTSQSEQ---QESVDAEGPVVEKIMSS
:.:::.:.::.: : :.::. . ..: : : : .. . .. .:.::.::
XP_016 QIKRKKYAEDIEGKQSEEEVKGSMKIKKNSAPLPGEQPLQLFVENPSEEDAAIVDKILSS
640 650 660 670 680 690
810 820 830 840 850 860
pF1KE9 RSVKKQKESGEEVEIEEFYVKYKNFSYLHCQWASIEDLEKDKRIQQKIKRFKAKQGQN-K
:.:::. : .. :::.:::::.:::::.::. :.: ::::::::::::: .:.: .
XP_016 RTVKKEISPGVMIDTEEFFVKYKNYSYLHCEWATEEQLLKDKRIQQKIKRFKLRQAQRAH
700 710 720 730 740 750
870 880 890 900 910 920
pF1KE9 FLSEIEDELFNPDYVEVDRIMDFARSTD-DRGEPVTHYLVKWCSLPYEDSTWERRQDIDQ
:....:.: ::::::::::... . : : :::: .:::::::::::::::: ..:.:
XP_016 FFADMEEEPFNPDYVEVDRVLEVSFCEDKDTGEPVIYYLVKWCSLPYEDSTWELKEDVDL
760 770 780 790 800 810
930 940 950 960 970 980
pF1KE9 AKIEEFEKLMSREPETERVERPPADDWKKSESSREYKNNNKLREYQLEGVNWLLFNWYNM
:::::::.:.. .:.:.:..:::.. ::: ..::.:::.:.::::::::.:::::::::
XP_016 AKIEEFEQLQASRPDTRRLDRPPSNIWKKIDQSRDYKNGNQLREYQLEGLNWLLFNWYNR
820 830 840 850 860 870
990 1000 1010 1020 1030 1040
pF1KE9 RNCILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTWTELNVVVY
:::::::::::::::::::::::: : ::.::::.::::::: ::::::::::..:::::
XP_016 RNCILADEMGLGKTIQSITFLYEILLTGIRGPFLIIAPLSTIANWEREFRTWTDINVVVY
880 890 900 910 920 930
1050 1060 1070 1080 1090 1100
pF1KE9 HGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAIITTFEMILTDCPELRNIPWRCVVIDE
::: ::. :: :::::.: :::.:.:.:.:.:::::::::: : :: : ::::.:::
XP_016 HGSLISRQMIQQYEMYFRDSQGRIIRGAYRFQAIITTFEMILGGCGELNAIEWRCVIIDE
940 950 960 970 980 990
1110 1120 1130 1140 1150 1160
pF1KE9 AHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEF
::::::.:::::::::.:.:::::::::::::::::::::::::::: :::::.::::::
XP_016 AHRLKNKNCKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEF
1000 1010 1020 1030 1040 1050
1170 1180 1190 1200 1210 1220
pF1KE9 GDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAPKEETIIEVELTNIQKKYYRAILEKNF
::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::
XP_016 GDLKTEEQVQKLQAILKPMMLRRLKEDVEKKLAPKEETIIEVELTNIQKKYYRAILEKNF
1060 1070 1080 1090 1100 1110
1230 1240 1250 1260 1270 1280
pF1KE9 TFLSKGGGQANVPNLLNTMMELRKCCNHPYLINGAEEKILEEFKETHNAESPDFQLQAMI
.:::::.::.:::::.::::::::::::::::.::::::: ::..:.: . ::.:::::
XP_016 SFLSKGAGQTNVPNLVNTMMELRKCCNHPYLIKGAEEKILGEFRDTYNPAASDFHLQAMI
1120 1130 1140 1150 1160 1170
1290 1300 1310 1320 1330 1340
pF1KE9 QAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLDILEDYLIQRRYPYERIDGRVRGNLRQ
:.:::::::::::::.:::::.:::::::::::::::::::..:: ::::::::::::::
XP_016 QSAGKLVLIDKLLPKMKAGGHKVLIFSQMVRCLDILEDYLIHKRYLYERIDGRVRGNLRQ
1180 1190 1200 1210 1220 1230
1350 1360 1370 1380 1390 1400
pF1KE9 AAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_016 AAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQN
1240 1250 1260 1270 1280 1290
1410 1420 1430 1440 1450 1460
pF1KE9 KSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQSMSGRENATNGVQQLSKKEIEDLLRK
:.::.:::.:::::::::::.:::::::::::::::::::. ..:.:::::::::::::.
XP_016 KAVKVYRLVTRNSYEREMFDRASLKLGLDKAVLQSMSGRESNVGGIQQLSKKEIEDLLRR
1300 1310 1320 1330 1340 1350
1470 1480 1490 1500 1510 1520
pF1KE9 GAYGALMDEEDEGSKFCEEDIDQILLRRTHTITIESEGKGSTFAKASFVASGNRTDISLD
:::::.:.:::::::::::::::::::::.::::::::.:::::::::::::::::::::
XP_016 GAYGAIMEEEDEGSKFCEEDIDQILLRRTKTITIESEGRGSTFAKASFVASGNRTDISLD
1360 1370 1380 1390 1400 1410
1530 1540 1550 1560 1570 1580
pF1KE9 DPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRKQTRLYSAVKEDELMEFSDLESDSEEK
:::::::::::::.::.:..:::.:::::::.::::: .::.: ::: :.:. ::...::
XP_016 DPNFWQKWAKKAEIDIEAISGRNSLVIDTPRIRKQTRPFSATK-DELAELSEAESEGDEK
1420 1430 1440 1450 1460 1470
1590 1600 1610 1620 1630 1640
pF1KE9 PCAKPRRPQDKSQGYARSECFRVEKNLLVYGWGRWTDILSHGRYKRQLTEQDVETICRTI
: : ::: :.:.::.:.::::::::::::::::: .::::::.::::.:.::: :::..
XP_016 P--KLRRPCDRSNGYGRTECFRVEKNLLVYGWGRWREILSHGRFKRQLNEHDVEIICRAL
1480 1490 1500 1510 1520 1530
1650 1660 1670 1680 1690 1700
pF1KE9 LVYCLNHYKGDENIKSFIWDLITPTADGQTRALVNHSGLSAPVPRGRKGKKVKAQSTQPV
:.::: ::.:::.::.::::::::: ::::: : :: ::::::::::::::::.:...
XP_016 LAYCLVHYRGDEKIKGFIWDLITPTEDGQTRELQNHLGLSAPVPRGRKGKKVKTQTSSFD
1540 1550 1560 1570 1580 1590
1710 1720 1730 1740 1750 1760
pF1KE9 VQDADWLASCNPDALFQEDSYKKHLKHHCNKVLLRVRMLYYLRQEVIGDQADKILEGADS
.: :.:: . ::. :.:...::::.:::::::::::::::::.:::::.. .:...:.:.
XP_016 IQKAEWLRKYNPEQLLQDEGYKKHIKHHCNKVLLRVRMLYYLKQEVIGNECQKVFDGVDA
1600 1610 1620 1630 1640 1650
1770 1780 1790 1800 1810 1820
pF1KE9 SEADVWIPEPFHAEVPADWWDKEADKSLLIGVFKHGYEKYNSMRADPALCFLERVGMPDA
:. :::.::: :.::::.::: .::::::::::::::::::..::::::::::::: ::
XP_016 SDIDVWVPEPDHSEVPAEWWDFDADKSLLIGVFKHGYEKYNTIRADPALCFLERVGKPDE
1660 1670 1680 1690 1700 1710
1830 1840 1850 1860 1870 1880
pF1KE9 KAIAAEQRGTDMLADGGDGGEFDREDEDPEYKPTRTPFKDEIDEFANSPSEDKEESMEIH
::.:::::..:.. :: . :::::::. . :::.:.. ..::.. .
XP_016 KAVAAEQRANDYM-DG--------DVEDPEYKPAPAIFKDDIEDDVSSPGD----LVIAD
1720 1730 1740 1750 1760
1890 1900 1910 1920 1930 1940
pF1KE9 ATGKHSESNAELGQLYWPNTSTLTTRLRRLITAYQRSYKRQQMRQ-EALMKTDRRRRRPR
. :. :.. ..:::. :.::::::::::::::. : .:..: . ... .:
XP_016 GDGQLMEGD----KVYWPTQSALTTRLRRLITAYQRTNKNRQIQQIQPTFSVPTSVMQPI
1770 1780 1790 1800 1810
1950 1960 1970 1980 1990 2000
pF1KE9 EEVRALEAEREAIISEKRQKWTRREEADFYRVVSTFGVIFDPVKQQFDWNQFRAFARLDK
: .:. . : : :..:.::::::::::::::::::.::: . ::::..:::.::: :
XP_016 YEEATLNPKMAAKI-ERQQRWTRREEADFYRVVSTFGVVFDPDRGQFDWTKFRAMARLHK
1820 1830 1840 1850 1860 1870
2010 2020 2030 2040 2050 2060
pF1KE9 KSDESLEKYFSCFVAMCRRVCRMPVKPDDEPPDLSSIIEPITEERASRTLYRIELLRKIR
:.:.:::::. :..:::::::.: : . :.. .:.:::::::::::::::::::.:
XP_016 KTDDSLEKYLYAFMSMCRRVCRLPSKEELVDPNI--FIQPITEERASRTLYRIELLRKVR
1880 1890 1900 1910 1920 1930
2070 2080 2090 2100 2110 2120
pF1KE9 EQVLHHPQLGERLKLCQPSLDLPEWWECGRHDRDLLVGAAKHGVSRTDYHILNDPELSFL
::.:.:::: ::::::.:. ::: ::::: ::::::.::::::::::::::: ::::::.
XP_016 EQALRHPQLFERLKLCHPNPDLPVWWECGPHDRDLLIGAAKHGVSRTDYHILRDPELSFM
1940 1950 1960 1970 1980 1990
2130 2140 2150 2160
pF1KE9 DAHKNFAQNRGAGNTSSL------------NPL--------AVGFVQTPPVISSAHIQDE
:..:..:.. : . .: .:: : :.. ..: ....:
XP_016 AAQRNYSQSKMAHSRTSTPLLQQYQVALSASPLTSLPRLLDAKGIILEEMKVKSENLKEE
2000 2010 2020 2030 2040 2050
2170 2180
pF1KE9 --------------RVLEQAE-------------------GKVE----------EP--EN
:.: ..: :: : :: :
XP_016 PQSSEEESMSSVETRTLIKSEPVSPKNGVLPQATGDQKSGGKCETDRRMVAARTEPLTPN
2060 2070 2080 2090 2100 2110
2190 2200 2210 2220 2230
pF1KE9 PAAKE---KCEGKEEEEETDGSGKESKQECEAEASSVKNELKGVEVGADTGSKSI-----
::.:. . .:.: ..:.....:. .. .:: .. . . :....:.:
XP_016 PASKKPRVHKRGSESSSDSDSDSERSSCSSRSSSSSSSSSCSHSRSGSSSSSSSSCSSAS
2120 2130 2140 2150 2160 2170
2240 2250 2260 2270 2280
pF1KE9 -----SEKGSEEDEEEKLEDDDKSEESSQPEAGAVSRGKNFDEESNASMSTARDETRDGF
: ..: . . :..:..:: .: .: .... : .:::: ::.::..:::.:.:
XP_016 SSSSSSTSSSSSSSSSSSEESDSDEEEAQKRAESTTHMKAYDEESVASLSTTQDETQDSF
2180 2190 2200 2210 2220 2230
2290 2300 2310 2320 2330 2340
pF1KE9 YMEDGDPSVAQLLHE-RTFAFSFWPKDRVMINRLDNICEAVLKGKWPVNRRQMFDFQGLI
:..: : : .:. .: :.::::::::::::.::..::::::: ::. .: . .
XP_016 QMNNGTPESAYILQGGYMLAASYWPKDRVMINRLDSICQTVLKGKWPSARRS-YDANTVA
2240 2250 2260 2270 2280 2290
2350 2360 2370 2380 2390 2400
pF1KE9 PGYTPTTVDSPLQKRSFAELSMVGQASISGSEDITTSPQLSKEDALNLSVPRQRRRRRRK
:: .::: ... :. . . .:. : :.::: .:.:. .: ..:
XP_016 SFYTTKLLDSPGAATEYSDPSVPTPPGAGVKEEHDQSTQMSKEGGLKLTFQKQGLAQKRP
2300 2310 2320 2330 2340 2350
2410 2420 2430 2440 2450 2460
pF1KE9 IEIEAERAAKRRNLMEMVAQLRESQVVSENGQEKVVDLSKASREATSSTSNFSSLSSKFI
.. : .... : ..::: : .:: .: ::
XP_016 FDGEDGALGQQQYL----TRLRELQSASE-----------------TSLVNF--------
2360 2370 2380
2470 2480 2490 2500 2510 2520
pF1KE9 LPNVSTPVSDAFKTQMELLQAGLSRTPTRHLLNGSLVDGEPPMKRRRGRRKNVEGLDLLF
:. : ::: : : :: :: ..:..: .:.::::::::::.:..:
XP_016 -PK-SIPVS------------GTSIQPTLGA-NGVILDNQPIVKKRRGRRKNVEGVDIFF
2390 2400 2410 2420 2430
2530 2540 2550 2560 2570 2580
pF1KE9 MSHKR----TSLSAEDAEVTKAFEEDIETPPTRNIPSPGQLDPDTRIPVINLEDGTRLVG
..... .::. ..... ... . ..:: : .. .:::::.:::::.:
XP_016 FNRNKPPNHVSLGLTSSQISTGINPALSYTQPQGIP-----DTESPVPVINLKDGTRLAG
2440 2450 2460 2470 2480
2590 2600 2610 2620 2630 2640
pF1KE9 EDAPKNKDLVEWLKLHPTYTVDMPSYVPKNADVLFSSFQKPKQKRHRCRNPNKLDINTLT
.:::: ::: .::: :: :. :. ...:. . .:::::::::::::::.:.::
XP_016 DDAPKRKDLEKWLKEHPGYVEDLGAFIPR----MQLHEGRPKQKRHRCRNPNKLDVNSLT
2490 2500 2510 2520 2530 2540
2650 2660 2670 2680 2690 2700
pF1KE9 GEERVPVVNKRNGKKMGGAMAPPMKDLPRWLEENPEFAVAPDWTDIVKQSGFVPESMFDR
::::: ..:.::..:.:::.:::.::: :.:.:: :..:::.: :.::::::.::::..:
XP_016 GEERVQLINRRNARKVGGAFAPPLKDLCRFLKENSEYGVAPEWGDVVKQSGFLPESMYER
2550 2560 2570 2580 2590 2600
2710 2720 2730 2740 2750
pF1KE9 LLTGPVVRGEGASRRGRRPKSEIARAAAAAAAVASTS-GINPLLVNSLFAGMDLTSLQ--
.::::::: : .::::::::: ::.:.:::::...:: . ::::.:.:. :.:::.::
XP_016 ILTGPVVR-EEVSRRGRRPKSGIAKATAAAAAASATSVSGNPLLANGLLPGVDLTTLQAL
2610 2620 2630 2640 2650 2660
2760 2770 2780 2790 2800 2810
pF1KE9 --NLQNLQSLQL-AGLMGFPPGLATAATAGGDAKNPAAVLPLMLPGMAGLPNVFGLGGLL
:::::::::. :::::.: :: . ::.::: ::..:..: :::::::..:.::::
XP_016 QQNLQNLQSLQVTAGLMGMPTGLPS----GGEAKNMAAMFPMLLSGMAGLPNLLGMGGLL
2670 2680 2690 2700 2710
2820 2830 2840 2850 2860 2870
pF1KE9 NNPLSAATGNTTTASSQGEPEDSTSKGEEKGNENEDENKDSEKSTDAVSAADSANGSVGA
..: ..: . ..:. : : .: . : ...:: :: .::.. :......
XP_016 TKPTESGTEDKKGSDSK-ESEGKTERTESQSSENGGEN--------SVSSSPSTSSTAAL
2720 2730 2740 2750 2760
2880 2890 2900 2910 2920 2930
pF1KE9 ATAPAGLPSNPLAFNPFLLSTMAPGLFYPSMFLPPGLGGLTLPGFPALAGLQNAVGSSEE
:: : .::::.::.:::.. .::.:.: :::. : .: . :. . . ..
XP_016 NTAAA---ANPLALNPLLLSNI----LYPGMLLTPGLN-LHIPTLS-----QSNTFDVQN
2770 2780 2790 2800 2810
2940 2950 2960 2970 2980 2990
pF1KE9 KAADKAEGGPFKDGETLEGSDAEESLDK--TAESSLLEDEIAQG-EELDSLDGGDEIENN
: .: . . . : : : ... :: : : : :. .: :. :. .:.: ..
XP_016 KNSDLGSSKSVEVKE--EDSRIKDQEDKGGTEPSPLNENSTDEGSEKADASSGSDSTSSS
2820 2830 2840 2850 2860 2870
pF1KE9 ENDE
.:
XP_016 SEDSDSSNED
2880
2997 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 19:38:46 2016 done: Sun Nov 6 19:38:50 2016
Total Scan time: 27.110 Total Display time: 2.970
Function used was FASTA [36.3.4 Apr, 2011]