Result of FASTA (omim) for
pF1KF0017
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KF0017, 394 aa
1>>>pF1KF0017 394 - 394 aa - 394 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.6373+/-0.000412; mu= 9.9694+/- 0.025
mean_var=112.0775+/-23.625, 0's: 0 Z-trim(113.5): 266 B-trim: 321 in 1/54
Lambda= 0.121148
statistics sampled from 22475 (22849) to 22475 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.639), E-opt: 0.2 (0.268), width: 16
Scan time: 6.140
The best scores are: opt bits E(85289)
NP_037517 (OMIM: 606514) cytohesin-4 isoform 1 [Ho ( 394) 2697 482.7 6.6e-136
NP_001304953 (OMIM: 606514) cytohesin-4 isoform 2 ( 337) 2312 415.3 1.1e-115
XP_011528449 (OMIM: 606514) PREDICTED: cytohesin-4 ( 337) 2312 415.3 1.1e-115
NP_004218 (OMIM: 605081) cytohesin-3 [Homo sapiens ( 399) 1994 359.8 6.5e-99
XP_006723535 (OMIM: 602488) PREDICTED: cytohesin-2 ( 421) 1944 351.1 2.9e-96
NP_004219 (OMIM: 602488) cytohesin-2 isoform 2 [Ho ( 399) 1939 350.2 5.1e-96
NP_059430 (OMIM: 182115) cytohesin-1 isoform 2 [Ho ( 397) 1927 348.1 2.2e-95
XP_016880825 (OMIM: 182115) PREDICTED: cytohesin-1 ( 399) 1927 348.1 2.2e-95
NP_059431 (OMIM: 602488) cytohesin-2 isoform 1 [Ho ( 400) 1927 348.1 2.2e-95
NP_004753 (OMIM: 182115) cytohesin-1 isoform 1 [Ho ( 398) 1915 346.0 9.3e-95
XP_006723536 (OMIM: 602488) PREDICTED: cytohesin-2 ( 394) 1860 336.4 7.2e-92
XP_016880826 (OMIM: 182115) PREDICTED: cytohesin-1 ( 380) 1845 333.8 4.3e-91
XP_016880827 (OMIM: 182115) PREDICTED: cytohesin-1 ( 338) 1787 323.6 4.4e-88
XP_011523779 (OMIM: 182115) PREDICTED: cytohesin-1 ( 339) 1775 321.5 1.9e-87
NP_001278947 (OMIM: 182115) cytohesin-1 isoform 3 ( 339) 1775 321.5 1.9e-87
NP_001278948 (OMIM: 182115) cytohesin-1 isoform 3 ( 339) 1775 321.5 1.9e-87
XP_011523778 (OMIM: 182115) PREDICTED: cytohesin-1 ( 322) 1693 307.1 3.8e-83
XP_011523777 (OMIM: 182115) PREDICTED: cytohesin-1 ( 322) 1693 307.1 3.8e-83
XP_011523780 (OMIM: 182115) PREDICTED: cytohesin-1 ( 235) 1252 230.0 4.6e-60
XP_011528450 (OMIM: 606514) PREDICTED: cytohesin-4 ( 211) 1119 206.7 4.2e-53
XP_011515744 (OMIM: 604141) PREDICTED: brefeldin A (1649) 603 117.1 3.1e-25
XP_005251193 (OMIM: 604141) PREDICTED: brefeldin A (1800) 603 117.1 3.3e-25
XP_005251192 (OMIM: 604141) PREDICTED: brefeldin A (1843) 603 117.1 3.4e-25
XP_005251191 (OMIM: 604141) PREDICTED: brefeldin A (1849) 603 117.1 3.4e-25
NP_006412 (OMIM: 604141) brefeldin A-inhibited gua (1849) 603 117.1 3.4e-25
XP_005260309 (OMIM: 605371,608097) PREDICTED: bref (1784) 569 111.2 2e-23
NP_006411 (OMIM: 605371,608097) brefeldin A-inhibi (1785) 569 111.2 2e-23
XP_011532617 (OMIM: 610166) PREDICTED: IQ motif an ( 814) 499 98.7 5.2e-20
NP_001317548 (OMIM: 610166) IQ motif and SEC7 doma ( 814) 499 98.7 5.2e-20
NP_055684 (OMIM: 610166) IQ motif and SEC7 domain- ( 963) 499 98.8 6e-20
XP_011532614 (OMIM: 610166) PREDICTED: IQ motif an (1006) 499 98.8 6.2e-20
XP_011532613 (OMIM: 610166) PREDICTED: IQ motif an (1006) 499 98.8 6.2e-20
XP_011532615 (OMIM: 610166) PREDICTED: IQ motif an (1006) 499 98.8 6.2e-20
XP_011532616 (OMIM: 610166) PREDICTED: IQ motif an (1006) 499 98.8 6.2e-20
XP_011532612 (OMIM: 610166) PREDICTED: IQ motif an (1030) 499 98.8 6.3e-20
NP_001127854 (OMIM: 610166) IQ motif and SEC7 doma (1114) 499 98.8 6.7e-20
XP_011532610 (OMIM: 610166) PREDICTED: IQ motif an (1128) 499 98.8 6.8e-20
XP_011532608 (OMIM: 610166) PREDICTED: IQ motif an (1129) 499 98.8 6.8e-20
XP_011532609 (OMIM: 610166) PREDICTED: IQ motif an (1129) 499 98.8 6.8e-20
XP_011532607 (OMIM: 610166) PREDICTED: IQ motif an (1132) 499 98.8 6.8e-20
XP_016863071 (OMIM: 610166) PREDICTED: IQ motif an (1207) 499 98.8 7.2e-20
XP_016863070 (OMIM: 610166) PREDICTED: IQ motif an (1212) 499 98.8 7.2e-20
XP_011532606 (OMIM: 610166) PREDICTED: IQ motif an (1222) 499 98.8 7.3e-20
XP_011538616 (OMIM: 603698) PREDICTED: Golgi-speci (1416) 484 96.3 5e-19
XP_011538615 (OMIM: 603698) PREDICTED: Golgi-speci (1638) 484 96.3 5.7e-19
XP_016872352 (OMIM: 603698) PREDICTED: Golgi-speci (1847) 484 96.3 6.2e-19
NP_001186308 (OMIM: 603698) Golgi-specific brefeld (1855) 484 96.3 6.2e-19
NP_001186307 (OMIM: 603698) Golgi-specific brefeld (1856) 484 96.3 6.3e-19
NP_004184 (OMIM: 603698) Golgi-specific brefeldin (1859) 484 96.3 6.3e-19
XP_005270318 (OMIM: 603698) PREDICTED: Golgi-speci (1860) 484 96.3 6.3e-19
>>NP_037517 (OMIM: 606514) cytohesin-4 isoform 1 [Homo s (394 aa)
initn: 2697 init1: 2697 opt: 2697 Z-score: 2560.9 bits: 482.7 E(85289): 6.6e-136
Smith-Waterman score: 2697; 100.0% identity (100.0% similar) in 394 aa overlap (1-394:1-394)
10 20 30 40 50 60
pF1KF0 MDLCHPEPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 MDLCHPEPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KF0 INLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 INLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KF0 STDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 STDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KF0 EPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 EPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KF0 GIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 GIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSA
310 320 330 340 350 360
370 380 390
pF1KF0 EERDQWIESIRASITRVPFYDLVSTRKKKIASKQ
::::::::::::::::::::::::::::::::::
NP_037 EERDQWIESIRASITRVPFYDLVSTRKKKIASKQ
370 380 390
>>NP_001304953 (OMIM: 606514) cytohesin-4 isoform 2 [Hom (337 aa)
initn: 2312 init1: 2312 opt: 2312 Z-score: 2198.2 bits: 415.3 E(85289): 1.1e-115
Smith-Waterman score: 2312; 100.0% identity (100.0% similar) in 337 aa overlap (58-394:1-337)
30 40 50 60 70 80
pF1KF0 QLLEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELCIGRKKFNMDPAKGIQYFIEHK
::::::::::::::::::::::::::::::
NP_001 MAQKEKELCIGRKKFNMDPAKGIQYFIEHK
10 20 30
90 100 110 120 130 140
pF1KF0 LLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQF
40 50 60 70 80 90
150 160 170 180 190 200
pF1KF0 LWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDR
100 110 120 130 140 150
210 220 230 240 250 260
pF1KF0 PPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIPEDDGNDLTHTFFNPDREGWLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIPEDDGNDLTHTFFNPDREGWLL
160 170 180 190 200 210
270 280 290 300 310 320
pF1KF0 KLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFCLELYNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFCLELYNP
220 230 240 250 260 270
330 340 350 360 370 380
pF1KF0 SCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASITRVPFYDLVSTRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASITRVPFYDLVSTRK
280 290 300 310 320 330
390
pF1KF0 KKIASKQ
:::::::
NP_001 KKIASKQ
>>XP_011528449 (OMIM: 606514) PREDICTED: cytohesin-4 iso (337 aa)
initn: 2312 init1: 2312 opt: 2312 Z-score: 2198.2 bits: 415.3 E(85289): 1.1e-115
Smith-Waterman score: 2312; 100.0% identity (100.0% similar) in 337 aa overlap (58-394:1-337)
30 40 50 60 70 80
pF1KF0 QLLEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELCIGRKKFNMDPAKGIQYFIEHK
::::::::::::::::::::::::::::::
XP_011 MAQKEKELCIGRKKFNMDPAKGIQYFIEHK
10 20 30
90 100 110 120 130 140
pF1KF0 LLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQF
40 50 60 70 80 90
150 160 170 180 190 200
pF1KF0 LWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDR
100 110 120 130 140 150
210 220 230 240 250 260
pF1KF0 PPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIPEDDGNDLTHTFFNPDREGWLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIPEDDGNDLTHTFFNPDREGWLL
160 170 180 190 200 210
270 280 290 300 310 320
pF1KF0 KLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFCLELYNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFCLELYNP
220 230 240 250 260 270
330 340 350 360 370 380
pF1KF0 SCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASITRVPFYDLVSTRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASITRVPFYDLVSTRK
280 290 300 310 320 330
390
pF1KF0 KKIASKQ
:::::::
XP_011 KKIASKQ
>>NP_004218 (OMIM: 605081) cytohesin-3 [Homo sapiens] (399 aa)
initn: 2032 init1: 1983 opt: 1994 Z-score: 1896.8 bits: 359.8 E(85289): 6.5e-99
Smith-Waterman score: 1994; 73.1% identity (91.7% similar) in 387 aa overlap (8-394:13-399)
10 20 30 40 50
pF1KF0 MDLCHPEPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEE
: .:: : ::: :. ..:.:..::..:: :::.:...:: . :.::
NP_004 MDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEE
10 20 30 40 50 60
60 70 80 90 100 110
pF1KF0 SRMAQKEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYL
:. .:..:.. .::::::::: ::::..::. :: . .:.:.:::::::::::.:: ::
NP_004 SKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KF0 GERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCN
:::: .:..::::::. ::::.:::::::::::::::::::::::::::::::.::::::
NP_004 GERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCN
130 140 150 160 170 180
180 190 200 210 220 230
pF1KF0 PGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLF
:::::::::::::::.:::::::::: ::::.: :::..::::::.:.::::. ::::.
NP_004 PGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLY
190 200 210 220 230 240
240 250 260 270 280 290
pF1KF0 DSIKSEPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTT
.:::.:::.::::::::::::::::::::::::::::::::::::::::::::::::.::
NP_004 ESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTT
250 260 270 280 290 300
300 310 320 330 340 350
pF1KF0 DKEPRGIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRI
::::::::::::::...:.::.:: :.:::::: .:: ::::::..:::::::.: :::
NP_004 DKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRI
310 320 330 340 350 360
360 370 380 390
pF1KF0 SATSAEERDQWIESIRASITRVPFYDLVSTRKKKIASKQ
:: : ::...:..::.:::.: ::::...:::..::.:.
NP_004 SAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK
370 380 390
>>XP_006723535 (OMIM: 602488) PREDICTED: cytohesin-2 iso (421 aa)
initn: 1916 init1: 1916 opt: 1944 Z-score: 1849.2 bits: 351.1 E(85289): 2.9e-96
Smith-Waterman score: 1944; 69.4% identity (90.5% similar) in 389 aa overlap (6-394:28-416)
10 20 30
pF1KF0 MDLCHPEPAELSSGETEELQRIKWHRKQLLEDIQKLKD
:.: .:. : ::. :. ....:: .::.:..
XP_006 MDPVVRITRSPATSPVMESENQGLSPLPKPPDLTPEERMELENIRRRKQELLVEIQRLRE
10 20 30 40 50 60
40 50 60 70 80 90
pF1KF0 EIADVFAQIDCFESAEESRMAQKEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIAR
:......... .:. : :. :..... .::::::::: ::::...:..:: ..:::
XP_006 ELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIAR
70 80 90 100 110 120
100 110 120 130 140 150
pF1KF0 FLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQ
:::::::::::::: :::::. .:: ::.:::: :::..:::::::::::::::::::::
XP_006 FLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQ
130 140 150 160 170 180
160 170 180 190 200 210
pF1KF0 KIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNR
:::::::::: :::::::::::::::::::::..::::::::::::::.: .::::.:::
XP_006 KIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNR
190 200 210 220 230 240
220 230 240 250 260 270
pF1KF0 GINNGSDLPEDQLRNLFDSIKSEPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKR
:::.:.::::. ::::.:::..:::.::::::::::::::::::::::::::::::::::
XP_006 GINEGGDLPEELLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKR
250 260 270 280 290 300
280 290 300 310 320 330
pF1KF0 RWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACK
::::::::::::::.::::::::::::::::...::::.:: :.::: :. .:: :::::
XP_006 RWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACK
310 320 330 340 350 360
340 350 360 370 380 390
pF1KF0 TDGDGRVVEGKHESYRISATSAEERDQWIESIRASITRVPFYDLVSTRKKKIASKQ
:..:::::::.: ::::: . ::.:.::.::.:... :::.....:::.:. :.
XP_006 TEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQ
370 380 390 400 410 420
XP_006 P
>>NP_004219 (OMIM: 602488) cytohesin-2 isoform 2 [Homo s (399 aa)
initn: 1939 init1: 1939 opt: 1939 Z-score: 1844.9 bits: 350.2 E(85289): 5.1e-96
Smith-Waterman score: 1939; 69.6% identity (90.5% similar) in 388 aa overlap (7-394:7-394)
10 20 30 40 50 60
pF1KF0 MDLCHPEPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQ
:: .:. : ::. :. ....:: .::.:..:......... .:. : :. :
NP_004 MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP
..... .::::::::: ::::...:..:: ..::::::::::::::::: :::::.
NP_004 RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KF0 INLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQ
.:: ::.:::: :::..::::::::::::::::::::::::::::::: :::::::::::
NP_004 LNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KF0 STDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKS
::::::::::..::::::::::::::.: .::::.::::::.:.::::. ::::.:::..
NP_004 STDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KF0 EPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPR
:::.::::::::::::::::::::::::::::::::::::::::::::::::.:::::::
NP_004 EPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KF0 GIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSA
:::::::::...::::.:: :.::: :. .:: ::::::..:::::::.: ::::: .
NP_004 GIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQ
310 320 330 340 350 360
370 380 390
pF1KF0 EERDQWIESIRASITRVPFYDLVSTRKKKIASKQ
::.:.::.::.:... :::.....:::.:. :.
NP_004 EEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
370 380 390
>>NP_059430 (OMIM: 182115) cytohesin-1 isoform 2 [Homo s (397 aa)
initn: 1925 init1: 1902 opt: 1927 Z-score: 1833.6 bits: 348.1 E(85289): 2.2e-95
Smith-Waterman score: 1927; 70.5% identity (89.4% similar) in 387 aa overlap (8-394:9-395)
10 20 30 40 50
pF1KF0 MDLCHPEPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMA
:..:.. : .::. :. ....:: :::.::::::.: .:. . :.:: .
NP_059 MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNM
10 20 30 40 50 60
60 70 80 90 100 110
pF1KF0 QKEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERD
:..:.. .::::::::: ::::..::. :: .:::.:::::::::::::: ::::::
NP_059 QRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD
70 80 90 100 110 120
120 130 140 150 160 170
pF1KF0 PINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVF
.:.:::.:::. :::..::::::::::::::::::::::::::::::: ::: :: :::
NP_059 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF
130 140 150 160 170 180
180 190 200 210 220 230
pF1KF0 QSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIK
:::::::::::.:::::::::::::.:.: :::..::::::.:.::::. ::::..:::
NP_059 QSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIK
190 200 210 220 230 240
240 250 260 270 280 290
pF1KF0 SEPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEP
.:::.::::::::::::::::::::::::::::::::::::::::::::::::.::::::
NP_059 NEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEP
250 260 270 280 290 300
300 310 320 330 340 350
pF1KF0 RGIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATS
::::::::::...:.: ::: :.::: :. . : ::::::..:::::::.: ::::: .
NP_059 RGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPT
310 320 330 340 350 360
360 370 380 390
pF1KF0 AEERDQWIESIRASITRVPFYDLVSTRKKKIASKQ
::...::. :.:.:.: :::.....::::..: .
NP_059 PEEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKRH
370 380 390
>>XP_016880825 (OMIM: 182115) PREDICTED: cytohesin-1 iso (399 aa)
initn: 1902 init1: 1902 opt: 1927 Z-score: 1833.5 bits: 348.1 E(85289): 2.2e-95
Smith-Waterman score: 1927; 70.5% identity (89.4% similar) in 387 aa overlap (8-394:11-397)
10 20 30 40 50
pF1KF0 MDLCHPEPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESR
:..:.. : .::. :. ....:: :::.::::::.: .:. . :.:: .
XP_016 MVLKTEEEDVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERK
10 20 30 40 50 60
60 70 80 90 100 110
pF1KF0 MAQKEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGE
:..:.. .::::::::: ::::..::. :: .:::.:::::::::::::: ::::
XP_016 NMQRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KF0 RDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPG
:: .:.:::.:::. :::..::::::::::::::::::::::::::::::: ::: :: :
XP_016 RDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNG
130 140 150 160 170 180
180 190 200 210 220 230
pF1KF0 VFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDS
:::::::::::::.:::::::::::::.:.: :::..::::::.:.::::. ::::..:
XP_016 VFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYES
190 200 210 220 230 240
240 250 260 270 280 290
pF1KF0 IKSEPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDK
::.:::.::::::::::::::::::::::::::::::::::::::::::::::::.::::
XP_016 IKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDK
250 260 270 280 290 300
300 310 320 330 340 350
pF1KF0 EPRGIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISA
::::::::::::...:.: ::: :.::: :. . : ::::::..:::::::.: :::::
XP_016 EPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISA
310 320 330 340 350 360
360 370 380 390
pF1KF0 TSAEERDQWIESIRASITRVPFYDLVSTRKKKIASKQ
. ::...::. :.:.:.: :::.....::::..: .
XP_016 PTPEEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKRH
370 380 390
>>NP_059431 (OMIM: 602488) cytohesin-2 isoform 1 [Homo s (400 aa)
initn: 1942 init1: 1314 opt: 1927 Z-score: 1833.5 bits: 348.1 E(85289): 2.2e-95
Smith-Waterman score: 1927; 69.4% identity (90.2% similar) in 389 aa overlap (7-394:7-395)
10 20 30 40 50 60
pF1KF0 MDLCHPEPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQ
:: .:. : ::. :. ....:: .::.:..:......... .:. : :. :
NP_059 MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDP
..... .::::::::: ::::...:..:: ..::::::::::::::::: :::::.
NP_059 RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KF0 INLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQ
.:: ::.:::: :::..::::::::::::::::::::::::::::::: :::::::::::
NP_059 LNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KF0 STDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKS
::::::::::..::::::::::::::.: .::::.::::::.:.::::. ::::.:::..
NP_059 STDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRN
190 200 210 220 230 240
250 260 270 280 290
pF1KF0 EPFSIPEDDGNDLTHTFFNPDREGWLLKLGG-RVKTWKRRWFILTDNCLYYFEFTTDKEP
:::.::::::::::::::::::::::::::: :::::::::::::::::::::.::::::
NP_059 EPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEP
250 260 270 280 290 300
300 310 320 330 340 350
pF1KF0 RGIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATS
::::::::::...::::.:: :.::: :. .:: ::::::..:::::::.: ::::: .
NP_059 RGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPT
310 320 330 340 350 360
360 370 380 390
pF1KF0 AEERDQWIESIRASITRVPFYDLVSTRKKKIASKQ
::.:.::.::.:... :::.....:::.:. :.
NP_059 QEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
370 380 390 400
>>NP_004753 (OMIM: 182115) cytohesin-1 isoform 1 [Homo s (398 aa)
initn: 1930 init1: 1322 opt: 1915 Z-score: 1822.2 bits: 346.0 E(85289): 9.3e-95
Smith-Waterman score: 1915; 70.4% identity (89.2% similar) in 388 aa overlap (8-394:9-396)
10 20 30 40 50
pF1KF0 MDLCHPEPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMA
:..:.. : .::. :. ....:: :::.::::::.: .:. . :.:: .
NP_004 MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNM
10 20 30 40 50 60
60 70 80 90 100 110
pF1KF0 QKEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERD
:..:.. .::::::::: ::::..::. :: .:::.:::::::::::::: ::::::
NP_004 QRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD
70 80 90 100 110 120
120 130 140 150 160 170
pF1KF0 PINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVF
.:.:::.:::. :::..::::::::::::::::::::::::::::::: ::: :: :::
NP_004 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF
130 140 150 160 170 180
180 190 200 210 220 230
pF1KF0 QSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIK
:::::::::::.:::::::::::::.:.: :::..::::::.:.::::. ::::..:::
NP_004 QSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIK
190 200 210 220 230 240
240 250 260 270 280 290
pF1KF0 SEPFSIPEDDGNDLTHTFFNPDREGWLLKLGG-RVKTWKRRWFILTDNCLYYFEFTTDKE
.:::.::::::::::::::::::::::::::: :::::::::::::::::::::.:::::
NP_004 NEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKE
250 260 270 280 290 300
300 310 320 330 340 350
pF1KF0 PRGIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISAT
:::::::::::...:.: ::: :.::: :. . : ::::::..:::::::.: :::::
NP_004 PRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAP
310 320 330 340 350 360
360 370 380 390
pF1KF0 SAEERDQWIESIRASITRVPFYDLVSTRKKKIASKQ
. ::...::. :.:.:.: :::.....::::..: .
NP_004 TPEEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKRH
370 380 390
394 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 20:03:10 2016 done: Fri Nov 4 20:03:11 2016
Total Scan time: 6.140 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]