Result of FASTA (omim) for
pF1KF0156
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KF0156, 1858 aa
1>>>pF1KF0156 1858 - 1858 aa - 1858 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.6831+/-0.000463; mu= 17.6221+/- 0.029
mean_var=112.9912+/-23.018, 0's: 0 Z-trim(111.9): 212 B-trim: 267 in 1/54
Lambda= 0.120657
statistics sampled from 20360 (20625) to 20360 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.586), E-opt: 0.2 (0.242), width: 16
Scan time: 18.360
The best scores are: opt bits E(85289)
XP_016871953 (OMIM: 613316) PREDICTED: WD repeat- (1992) 12047 2109.8 0
XP_011538290 (OMIM: 613316) PREDICTED: WD repeat- (3184) 12047 2110.0 0
NP_065996 (OMIM: 613316) WD repeat- and FYVE domai (3184) 12047 2110.0 0
XP_005270061 (OMIM: 613316) PREDICTED: WD repeat- (3184) 12047 2110.0 0
XP_016871952 (OMIM: 613316) PREDICTED: WD repeat- (3184) 12047 2110.0 0
XP_011538288 (OMIM: 613316) PREDICTED: WD repeat- (3224) 12047 2110.0 0
XP_011538289 (OMIM: 613316) PREDICTED: WD repeat- (3217) 11977 2097.8 0
XP_011538292 (OMIM: 613316) PREDICTED: WD repeat- (2435) 7072 1243.9 0
XP_011538293 (OMIM: 613316) PREDICTED: WD repeat- (2045) 4426 783.2 0
XP_016871954 (OMIM: 613316) PREDICTED: WD repeat- (1614) 1908 344.9 3.9e-93
XP_011538294 (OMIM: 613316) PREDICTED: WD repeat- (1654) 1908 344.9 4e-93
XP_016861506 (OMIM: 139090,614169) PREDICTED: neur (1606) 1149 212.7 2.3e-53
XP_016861505 (OMIM: 139090,614169) PREDICTED: neur (2602) 1149 212.9 3.4e-53
XP_016861504 (OMIM: 139090,614169) PREDICTED: neur (2659) 1149 212.9 3.5e-53
XP_006713135 (OMIM: 139090,614169) PREDICTED: neur (2727) 1149 212.9 3.5e-53
XP_016861503 (OMIM: 139090,614169) PREDICTED: neur (2748) 1149 212.9 3.6e-53
NP_055990 (OMIM: 139090,614169) neurobeachin-like (2754) 1149 212.9 3.6e-53
XP_016861501 (OMIM: 139090,614169) PREDICTED: neur (2755) 1149 212.9 3.6e-53
XP_016861500 (OMIM: 139090,614169) PREDICTED: neur (2775) 1149 212.9 3.6e-53
XP_016861499 (OMIM: 139090,614169) PREDICTED: neur (2782) 1149 212.9 3.6e-53
NP_001191126 (OMIM: 604889) neurobeachin isoform 2 ( 739) 1140 211.0 3.7e-53
XP_016876034 (OMIM: 604889) PREDICTED: neurobeachi (2940) 1140 211.3 1.1e-52
XP_006719869 (OMIM: 604889) PREDICTED: neurobeachi (2943) 1140 211.3 1.1e-52
NP_056493 (OMIM: 604889) neurobeachin isoform 1 [H (2946) 1140 211.3 1.1e-52
XP_016864363 (OMIM: 606453,614700) PREDICTED: lipo ( 756) 1096 203.3 7.5e-51
XP_016864362 (OMIM: 606453,614700) PREDICTED: lipo ( 758) 1096 203.3 7.6e-51
NP_001186211 (OMIM: 606453,614700) lipopolysacchar (2851) 1100 204.4 1.4e-50
XP_005263432 (OMIM: 606453,614700) PREDICTED: lipo (2852) 1100 204.4 1.4e-50
XP_011530736 (OMIM: 606453,614700) PREDICTED: lipo (2863) 1100 204.4 1.4e-50
NP_006717 (OMIM: 606453,614700) lipopolysaccharide (2863) 1100 204.4 1.4e-50
XP_016860218 (OMIM: 609816) PREDICTED: neurobeachi (1547) 1092 202.8 2.2e-50
XP_005263431 (OMIM: 606453,614700) PREDICTED: lipo (2857) 1096 203.7 2.2e-50
XP_016864361 (OMIM: 606453,614700) PREDICTED: lipo (2857) 1096 203.7 2.2e-50
XP_005263430 (OMIM: 606453,614700) PREDICTED: lipo (2868) 1096 203.7 2.2e-50
XP_005263429 (OMIM: 606453,614700) PREDICTED: lipo (2868) 1096 203.7 2.2e-50
XP_005246845 (OMIM: 609816) PREDICTED: neurobeachi (1624) 1092 202.8 2.3e-50
XP_016860217 (OMIM: 609816) PREDICTED: neurobeachi (2080) 1092 202.9 2.8e-50
XP_011509964 (OMIM: 609816) PREDICTED: neurobeachi (2387) 1092 202.9 3.1e-50
XP_011509962 (OMIM: 609816) PREDICTED: neurobeachi (2598) 1092 203.0 3.3e-50
NP_001107604 (OMIM: 609816) neurobeachin-like prot (2694) 1092 203.0 3.4e-50
XP_005246844 (OMIM: 609816) PREDICTED: neurobeachi (2707) 1092 203.0 3.4e-50
XP_006712762 (OMIM: 609816) PREDICTED: neurobeachi (2723) 1092 203.0 3.4e-50
XP_006712761 (OMIM: 609816) PREDICTED: neurobeachi (2736) 1092 203.0 3.4e-50
XP_011509960 (OMIM: 609816) PREDICTED: neurobeachi (2736) 1092 203.0 3.4e-50
XP_011509961 (OMIM: 609816) PREDICTED: neurobeachi (2736) 1092 203.0 3.4e-50
XP_006719868 (OMIM: 604889) PREDICTED: neurobeachi (2938) 1077 200.4 2.2e-49
XP_005266403 (OMIM: 604889) PREDICTED: neurobeachi (2941) 1077 200.4 2.2e-49
XP_011531835 (OMIM: 139090,614169) PREDICTED: neur (2724) 1052 196.0 4.3e-48
XP_016861502 (OMIM: 139090,614169) PREDICTED: neur (2752) 1052 196.0 4.3e-48
XP_006719866 (OMIM: 604889) PREDICTED: neurobeachi (2962) 1006 188.0 1.2e-45
>>XP_016871953 (OMIM: 613316) PREDICTED: WD repeat- and (1992 aa)
initn: 12041 init1: 12041 opt: 12047 Z-score: 11330.0 bits: 2109.8 E(85289): 0
Smith-Waterman score: 12047; 97.5% identity (98.2% similar) in 1848 aa overlap (1-1845:127-1974)
10 20 30
pF1KF0 MNISSRDNAMPVFLLRNCAGHLSGSLRTIG
::::::::::::::::::::::::::::::
XP_016 GLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIG
100 110 120 130 140 150
40 50 60 70 80 90
pF1KF0 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
160 170 180 190 200 210
100 110 120 130 140 150
pF1KF0 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
220 230 240 250 260 270
160 170 180 190 200 210
pF1KF0 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
280 290 300 310 320 330
220 230 240 250 260 270
pF1KF0 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
340 350 360 370 380 390
280 290 300 310 320 330
pF1KF0 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
400 410 420 430 440 450
340 350 360 370 380 390
pF1KF0 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
460 470 480 490 500 510
400 410 420 430 440 450
pF1KF0 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
520 530 540 550 560 570
460 470 480 490 500 510
pF1KF0 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
580 590 600 610 620 630
520 530 540 550 560 570
pF1KF0 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
640 650 660 670 680 690
580 590 600 610 620 630
pF1KF0 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
700 710 720 730 740 750
640 650 660 670 680 690
pF1KF0 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
760 770 780 790 800 810
700 710 720 730 740 750
pF1KF0 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
820 830 840 850 860 870
760 770 780 790 800 810
pF1KF0 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
880 890 900 910 920 930
820 830 840 850 860 870
pF1KF0 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
940 950 960 970 980 990
880 890 900 910 920 930
pF1KF0 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
1000 1010 1020 1030 1040 1050
940 950 960 970 980 990
pF1KF0 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
1060 1070 1080 1090 1100 1110
1000 1010 1020 1030 1040 1050
pF1KF0 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
1120 1130 1140 1150 1160 1170
1060 1070 1080 1090 1100 1110
pF1KF0 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
1180 1190 1200 1210 1220 1230
1120 1130 1140 1150 1160 1170
pF1KF0 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
1240 1250 1260 1270 1280 1290
1180 1190 1200 1210 1220 1230
pF1KF0 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLNLRRYPGSDRIMLQKWQKRDIS
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
XP_016 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQKRDIS
1300 1310 1320 1330 1340 1350
1240 1250 1260 1270 1280 1290
pF1KF0 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
1360 1370 1380 1390 1400 1410
1300 1310 1320 1330 1340 1350
pF1KF0 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
1420 1430 1440 1450 1460 1470
1360 1370 1380 1390 1400 1410
pF1KF0 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
1480 1490 1500 1510 1520 1530
1420 1430 1440 1450 1460 1470
pF1KF0 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
1540 1550 1560 1570 1580 1590
1480 1490 1500 1510 1520 1530
pF1KF0 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
1600 1610 1620 1630 1640 1650
1540 1550 1560 1570 1580 1590
pF1KF0 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
1660 1670 1680 1690 1700 1710
1600 1610 1620 1630 1640 1650
pF1KF0 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
1720 1730 1740 1750 1760 1770
1660 1670 1680 1690 1700 1710
pF1KF0 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
1780 1790 1800 1810 1820 1830
1720 1730 1740 1750 1760 1770
pF1KF0 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
1840 1850 1860 1870 1880 1890
1780 1790 1800 1810 1820
pF1KF0 TGSQDGMVRVWKTEDVKMSVPGLQMGRKREAAEALAQQCQAEGGRG---DWGLSSAYRRN
:::::::::::::::::::::: :.. : . . : . . . .: : .
XP_016 TGSQDGMVRVWKTEDVKMSVPGRPAGEEPPAQPPSPRGHKWEKNLALSRELDVSIALTGK
1900 1910 1920 1930 1940 1950
1830 1840 1850
pF1KF0 PQGLLPHSSQGRASGNHSSAAQPSPWPMGLL
:. : . .: ::.
XP_016 PSKTSPAVTALAVSRNHTKLLVGDERGRIFCWSADG
1960 1970 1980 1990
>>XP_011538290 (OMIM: 613316) PREDICTED: WD repeat- and (3184 aa)
initn: 12041 init1: 12041 opt: 12047 Z-score: 11327.1 bits: 2110.0 E(85289): 0
Smith-Waterman score: 12047; 97.5% identity (98.2% similar) in 1848 aa overlap (1-1845:1319-3166)
10 20 30
pF1KF0 MNISSRDNAMPVFLLRNCAGHLSGSLRTIG
::::::::::::::::::::::::::::::
XP_011 GLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIG
1290 1300 1310 1320 1330 1340
40 50 60 70 80 90
pF1KF0 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
1350 1360 1370 1380 1390 1400
100 110 120 130 140 150
pF1KF0 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
1410 1420 1430 1440 1450 1460
160 170 180 190 200 210
pF1KF0 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
1470 1480 1490 1500 1510 1520
220 230 240 250 260 270
pF1KF0 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
1530 1540 1550 1560 1570 1580
280 290 300 310 320 330
pF1KF0 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
1590 1600 1610 1620 1630 1640
340 350 360 370 380 390
pF1KF0 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
1650 1660 1670 1680 1690 1700
400 410 420 430 440 450
pF1KF0 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
1710 1720 1730 1740 1750 1760
460 470 480 490 500 510
pF1KF0 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
1770 1780 1790 1800 1810 1820
520 530 540 550 560 570
pF1KF0 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
1830 1840 1850 1860 1870 1880
580 590 600 610 620 630
pF1KF0 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
1890 1900 1910 1920 1930 1940
640 650 660 670 680 690
pF1KF0 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
1950 1960 1970 1980 1990 2000
700 710 720 730 740 750
pF1KF0 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
2010 2020 2030 2040 2050 2060
760 770 780 790 800 810
pF1KF0 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
2070 2080 2090 2100 2110 2120
820 830 840 850 860 870
pF1KF0 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
2130 2140 2150 2160 2170 2180
880 890 900 910 920 930
pF1KF0 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
2190 2200 2210 2220 2230 2240
940 950 960 970 980 990
pF1KF0 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
2250 2260 2270 2280 2290 2300
1000 1010 1020 1030 1040 1050
pF1KF0 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
2310 2320 2330 2340 2350 2360
1060 1070 1080 1090 1100 1110
pF1KF0 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
2370 2380 2390 2400 2410 2420
1120 1130 1140 1150 1160 1170
pF1KF0 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
2430 2440 2450 2460 2470 2480
1180 1190 1200 1210 1220 1230
pF1KF0 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLNLRRYPGSDRIMLQKWQKRDIS
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
XP_011 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQKRDIS
2490 2500 2510 2520 2530 2540
1240 1250 1260 1270 1280 1290
pF1KF0 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
2550 2560 2570 2580 2590 2600
1300 1310 1320 1330 1340 1350
pF1KF0 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
2610 2620 2630 2640 2650 2660
1360 1370 1380 1390 1400 1410
pF1KF0 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
2670 2680 2690 2700 2710 2720
1420 1430 1440 1450 1460 1470
pF1KF0 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
2730 2740 2750 2760 2770 2780
1480 1490 1500 1510 1520 1530
pF1KF0 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
2790 2800 2810 2820 2830 2840
1540 1550 1560 1570 1580 1590
pF1KF0 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
2850 2860 2870 2880 2890 2900
1600 1610 1620 1630 1640 1650
pF1KF0 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
2910 2920 2930 2940 2950 2960
1660 1670 1680 1690 1700 1710
pF1KF0 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
2970 2980 2990 3000 3010 3020
1720 1730 1740 1750 1760 1770
pF1KF0 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
3030 3040 3050 3060 3070 3080
1780 1790 1800 1810 1820
pF1KF0 TGSQDGMVRVWKTEDVKMSVPGLQMGRKREAAEALAQQCQAEGGRG---DWGLSSAYRRN
:::::::::::::::::::::: :.. : . . : . . . .: : .
XP_011 TGSQDGMVRVWKTEDVKMSVPGRPAGEEPPAQPPSPRGHKWEKNLALSRELDVSIALTGK
3090 3100 3110 3120 3130 3140
1830 1840 1850
pF1KF0 PQGLLPHSSQGRASGNHSSAAQPSPWPMGLL
:. : . .: ::.
XP_011 PSKTSPAVTALAVSRNHTKLLVGDERGRIFCWSADG
3150 3160 3170 3180
>>NP_065996 (OMIM: 613316) WD repeat- and FYVE domain-co (3184 aa)
initn: 12041 init1: 12041 opt: 12047 Z-score: 11327.1 bits: 2110.0 E(85289): 0
Smith-Waterman score: 12047; 97.5% identity (98.2% similar) in 1848 aa overlap (1-1845:1319-3166)
10 20 30
pF1KF0 MNISSRDNAMPVFLLRNCAGHLSGSLRTIG
::::::::::::::::::::::::::::::
NP_065 GLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIG
1290 1300 1310 1320 1330 1340
40 50 60 70 80 90
pF1KF0 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
1350 1360 1370 1380 1390 1400
100 110 120 130 140 150
pF1KF0 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
1410 1420 1430 1440 1450 1460
160 170 180 190 200 210
pF1KF0 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
1470 1480 1490 1500 1510 1520
220 230 240 250 260 270
pF1KF0 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
1530 1540 1550 1560 1570 1580
280 290 300 310 320 330
pF1KF0 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
1590 1600 1610 1620 1630 1640
340 350 360 370 380 390
pF1KF0 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
1650 1660 1670 1680 1690 1700
400 410 420 430 440 450
pF1KF0 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
1710 1720 1730 1740 1750 1760
460 470 480 490 500 510
pF1KF0 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
1770 1780 1790 1800 1810 1820
520 530 540 550 560 570
pF1KF0 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
1830 1840 1850 1860 1870 1880
580 590 600 610 620 630
pF1KF0 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
1890 1900 1910 1920 1930 1940
640 650 660 670 680 690
pF1KF0 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
1950 1960 1970 1980 1990 2000
700 710 720 730 740 750
pF1KF0 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
2010 2020 2030 2040 2050 2060
760 770 780 790 800 810
pF1KF0 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
2070 2080 2090 2100 2110 2120
820 830 840 850 860 870
pF1KF0 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
2130 2140 2150 2160 2170 2180
880 890 900 910 920 930
pF1KF0 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
2190 2200 2210 2220 2230 2240
940 950 960 970 980 990
pF1KF0 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
2250 2260 2270 2280 2290 2300
1000 1010 1020 1030 1040 1050
pF1KF0 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
2310 2320 2330 2340 2350 2360
1060 1070 1080 1090 1100 1110
pF1KF0 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
2370 2380 2390 2400 2410 2420
1120 1130 1140 1150 1160 1170
pF1KF0 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
2430 2440 2450 2460 2470 2480
1180 1190 1200 1210 1220 1230
pF1KF0 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLNLRRYPGSDRIMLQKWQKRDIS
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
NP_065 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQKRDIS
2490 2500 2510 2520 2530 2540
1240 1250 1260 1270 1280 1290
pF1KF0 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
2550 2560 2570 2580 2590 2600
1300 1310 1320 1330 1340 1350
pF1KF0 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
2610 2620 2630 2640 2650 2660
1360 1370 1380 1390 1400 1410
pF1KF0 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
2670 2680 2690 2700 2710 2720
1420 1430 1440 1450 1460 1470
pF1KF0 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
2730 2740 2750 2760 2770 2780
1480 1490 1500 1510 1520 1530
pF1KF0 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
2790 2800 2810 2820 2830 2840
1540 1550 1560 1570 1580 1590
pF1KF0 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
2850 2860 2870 2880 2890 2900
1600 1610 1620 1630 1640 1650
pF1KF0 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
2910 2920 2930 2940 2950 2960
1660 1670 1680 1690 1700 1710
pF1KF0 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
2970 2980 2990 3000 3010 3020
1720 1730 1740 1750 1760 1770
pF1KF0 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
3030 3040 3050 3060 3070 3080
1780 1790 1800 1810 1820
pF1KF0 TGSQDGMVRVWKTEDVKMSVPGLQMGRKREAAEALAQQCQAEGGRG---DWGLSSAYRRN
:::::::::::::::::::::: :.. : . . : . . . .: : .
NP_065 TGSQDGMVRVWKTEDVKMSVPGRPAGEEPPAQPPSPRGHKWEKNLALSRELDVSIALTGK
3090 3100 3110 3120 3130 3140
1830 1840 1850
pF1KF0 PQGLLPHSSQGRASGNHSSAAQPSPWPMGLL
:. : . .: ::.
NP_065 PSKTSPAVTALAVSRNHTKLLVGDERGRIFCWSADG
3150 3160 3170 3180
>>XP_005270061 (OMIM: 613316) PREDICTED: WD repeat- and (3184 aa)
initn: 12041 init1: 12041 opt: 12047 Z-score: 11327.1 bits: 2110.0 E(85289): 0
Smith-Waterman score: 12047; 97.5% identity (98.2% similar) in 1848 aa overlap (1-1845:1319-3166)
10 20 30
pF1KF0 MNISSRDNAMPVFLLRNCAGHLSGSLRTIG
::::::::::::::::::::::::::::::
XP_005 GLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIG
1290 1300 1310 1320 1330 1340
40 50 60 70 80 90
pF1KF0 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
1350 1360 1370 1380 1390 1400
100 110 120 130 140 150
pF1KF0 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
1410 1420 1430 1440 1450 1460
160 170 180 190 200 210
pF1KF0 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
1470 1480 1490 1500 1510 1520
220 230 240 250 260 270
pF1KF0 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
1530 1540 1550 1560 1570 1580
280 290 300 310 320 330
pF1KF0 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
1590 1600 1610 1620 1630 1640
340 350 360 370 380 390
pF1KF0 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
1650 1660 1670 1680 1690 1700
400 410 420 430 440 450
pF1KF0 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
1710 1720 1730 1740 1750 1760
460 470 480 490 500 510
pF1KF0 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
1770 1780 1790 1800 1810 1820
520 530 540 550 560 570
pF1KF0 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
1830 1840 1850 1860 1870 1880
580 590 600 610 620 630
pF1KF0 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
1890 1900 1910 1920 1930 1940
640 650 660 670 680 690
pF1KF0 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
1950 1960 1970 1980 1990 2000
700 710 720 730 740 750
pF1KF0 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
2010 2020 2030 2040 2050 2060
760 770 780 790 800 810
pF1KF0 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
2070 2080 2090 2100 2110 2120
820 830 840 850 860 870
pF1KF0 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
2130 2140 2150 2160 2170 2180
880 890 900 910 920 930
pF1KF0 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
2190 2200 2210 2220 2230 2240
940 950 960 970 980 990
pF1KF0 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
2250 2260 2270 2280 2290 2300
1000 1010 1020 1030 1040 1050
pF1KF0 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
2310 2320 2330 2340 2350 2360
1060 1070 1080 1090 1100 1110
pF1KF0 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
2370 2380 2390 2400 2410 2420
1120 1130 1140 1150 1160 1170
pF1KF0 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
2430 2440 2450 2460 2470 2480
1180 1190 1200 1210 1220 1230
pF1KF0 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLNLRRYPGSDRIMLQKWQKRDIS
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
XP_005 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQKRDIS
2490 2500 2510 2520 2530 2540
1240 1250 1260 1270 1280 1290
pF1KF0 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
2550 2560 2570 2580 2590 2600
1300 1310 1320 1330 1340 1350
pF1KF0 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
2610 2620 2630 2640 2650 2660
1360 1370 1380 1390 1400 1410
pF1KF0 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
2670 2680 2690 2700 2710 2720
1420 1430 1440 1450 1460 1470
pF1KF0 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
2730 2740 2750 2760 2770 2780
1480 1490 1500 1510 1520 1530
pF1KF0 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
2790 2800 2810 2820 2830 2840
1540 1550 1560 1570 1580 1590
pF1KF0 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
2850 2860 2870 2880 2890 2900
1600 1610 1620 1630 1640 1650
pF1KF0 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
2910 2920 2930 2940 2950 2960
1660 1670 1680 1690 1700 1710
pF1KF0 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
2970 2980 2990 3000 3010 3020
1720 1730 1740 1750 1760 1770
pF1KF0 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
3030 3040 3050 3060 3070 3080
1780 1790 1800 1810 1820
pF1KF0 TGSQDGMVRVWKTEDVKMSVPGLQMGRKREAAEALAQQCQAEGGRG---DWGLSSAYRRN
:::::::::::::::::::::: :.. : . . : . . . .: : .
XP_005 TGSQDGMVRVWKTEDVKMSVPGRPAGEEPPAQPPSPRGHKWEKNLALSRELDVSIALTGK
3090 3100 3110 3120 3130 3140
1830 1840 1850
pF1KF0 PQGLLPHSSQGRASGNHSSAAQPSPWPMGLL
:. : . .: ::.
XP_005 PSKTSPAVTALAVSRNHTKLLVGDERGRIFCWSADG
3150 3160 3170 3180
>>XP_016871952 (OMIM: 613316) PREDICTED: WD repeat- and (3184 aa)
initn: 12041 init1: 12041 opt: 12047 Z-score: 11327.1 bits: 2110.0 E(85289): 0
Smith-Waterman score: 12047; 97.5% identity (98.2% similar) in 1848 aa overlap (1-1845:1319-3166)
10 20 30
pF1KF0 MNISSRDNAMPVFLLRNCAGHLSGSLRTIG
::::::::::::::::::::::::::::::
XP_016 GLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIG
1290 1300 1310 1320 1330 1340
40 50 60 70 80 90
pF1KF0 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
1350 1360 1370 1380 1390 1400
100 110 120 130 140 150
pF1KF0 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
1410 1420 1430 1440 1450 1460
160 170 180 190 200 210
pF1KF0 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
1470 1480 1490 1500 1510 1520
220 230 240 250 260 270
pF1KF0 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
1530 1540 1550 1560 1570 1580
280 290 300 310 320 330
pF1KF0 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
1590 1600 1610 1620 1630 1640
340 350 360 370 380 390
pF1KF0 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
1650 1660 1670 1680 1690 1700
400 410 420 430 440 450
pF1KF0 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
1710 1720 1730 1740 1750 1760
460 470 480 490 500 510
pF1KF0 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
1770 1780 1790 1800 1810 1820
520 530 540 550 560 570
pF1KF0 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
1830 1840 1850 1860 1870 1880
580 590 600 610 620 630
pF1KF0 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
1890 1900 1910 1920 1930 1940
640 650 660 670 680 690
pF1KF0 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
1950 1960 1970 1980 1990 2000
700 710 720 730 740 750
pF1KF0 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
2010 2020 2030 2040 2050 2060
760 770 780 790 800 810
pF1KF0 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
2070 2080 2090 2100 2110 2120
820 830 840 850 860 870
pF1KF0 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
2130 2140 2150 2160 2170 2180
880 890 900 910 920 930
pF1KF0 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
2190 2200 2210 2220 2230 2240
940 950 960 970 980 990
pF1KF0 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
2250 2260 2270 2280 2290 2300
1000 1010 1020 1030 1040 1050
pF1KF0 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
2310 2320 2330 2340 2350 2360
1060 1070 1080 1090 1100 1110
pF1KF0 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
2370 2380 2390 2400 2410 2420
1120 1130 1140 1150 1160 1170
pF1KF0 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
2430 2440 2450 2460 2470 2480
1180 1190 1200 1210 1220 1230
pF1KF0 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLNLRRYPGSDRIMLQKWQKRDIS
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
XP_016 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQKRDIS
2490 2500 2510 2520 2530 2540
1240 1250 1260 1270 1280 1290
pF1KF0 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
2550 2560 2570 2580 2590 2600
1300 1310 1320 1330 1340 1350
pF1KF0 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
2610 2620 2630 2640 2650 2660
1360 1370 1380 1390 1400 1410
pF1KF0 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
2670 2680 2690 2700 2710 2720
1420 1430 1440 1450 1460 1470
pF1KF0 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
2730 2740 2750 2760 2770 2780
1480 1490 1500 1510 1520 1530
pF1KF0 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
2790 2800 2810 2820 2830 2840
1540 1550 1560 1570 1580 1590
pF1KF0 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
2850 2860 2870 2880 2890 2900
1600 1610 1620 1630 1640 1650
pF1KF0 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
2910 2920 2930 2940 2950 2960
1660 1670 1680 1690 1700 1710
pF1KF0 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
2970 2980 2990 3000 3010 3020
1720 1730 1740 1750 1760 1770
pF1KF0 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
3030 3040 3050 3060 3070 3080
1780 1790 1800 1810 1820
pF1KF0 TGSQDGMVRVWKTEDVKMSVPGLQMGRKREAAEALAQQCQAEGGRG---DWGLSSAYRRN
:::::::::::::::::::::: :.. : . . : . . . .: : .
XP_016 TGSQDGMVRVWKTEDVKMSVPGRPAGEEPPAQPPSPRGHKWEKNLALSRELDVSIALTGK
3090 3100 3110 3120 3130 3140
1830 1840 1850
pF1KF0 PQGLLPHSSQGRASGNHSSAAQPSPWPMGLL
:. : . .: ::.
XP_016 PSKTSPAVTALAVSRNHTKLLVGDERGRIFCWSADG
3150 3160 3170 3180
>>XP_011538288 (OMIM: 613316) PREDICTED: WD repeat- and (3224 aa)
initn: 12041 init1: 12041 opt: 12047 Z-score: 11327.0 bits: 2110.0 E(85289): 0
Smith-Waterman score: 12047; 97.5% identity (98.2% similar) in 1848 aa overlap (1-1845:1359-3206)
10 20 30
pF1KF0 MNISSRDNAMPVFLLRNCAGHLSGSLRTIG
::::::::::::::::::::::::::::::
XP_011 GLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIG
1330 1340 1350 1360 1370 1380
40 50 60 70 80 90
pF1KF0 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
1390 1400 1410 1420 1430 1440
100 110 120 130 140 150
pF1KF0 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
1450 1460 1470 1480 1490 1500
160 170 180 190 200 210
pF1KF0 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
1510 1520 1530 1540 1550 1560
220 230 240 250 260 270
pF1KF0 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
1570 1580 1590 1600 1610 1620
280 290 300 310 320 330
pF1KF0 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
1630 1640 1650 1660 1670 1680
340 350 360 370 380 390
pF1KF0 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
1690 1700 1710 1720 1730 1740
400 410 420 430 440 450
pF1KF0 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
1750 1760 1770 1780 1790 1800
460 470 480 490 500 510
pF1KF0 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
1810 1820 1830 1840 1850 1860
520 530 540 550 560 570
pF1KF0 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
1870 1880 1890 1900 1910 1920
580 590 600 610 620 630
pF1KF0 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
1930 1940 1950 1960 1970 1980
640 650 660 670 680 690
pF1KF0 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
1990 2000 2010 2020 2030 2040
700 710 720 730 740 750
pF1KF0 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
2050 2060 2070 2080 2090 2100
760 770 780 790 800 810
pF1KF0 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
2110 2120 2130 2140 2150 2160
820 830 840 850 860 870
pF1KF0 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
2170 2180 2190 2200 2210 2220
880 890 900 910 920 930
pF1KF0 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
2230 2240 2250 2260 2270 2280
940 950 960 970 980 990
pF1KF0 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
2290 2300 2310 2320 2330 2340
1000 1010 1020 1030 1040 1050
pF1KF0 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
2350 2360 2370 2380 2390 2400
1060 1070 1080 1090 1100 1110
pF1KF0 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
2410 2420 2430 2440 2450 2460
1120 1130 1140 1150 1160 1170
pF1KF0 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
2470 2480 2490 2500 2510 2520
1180 1190 1200 1210 1220 1230
pF1KF0 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLNLRRYPGSDRIMLQKWQKRDIS
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
XP_011 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQKRDIS
2530 2540 2550 2560 2570 2580
1240 1250 1260 1270 1280 1290
pF1KF0 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
2590 2600 2610 2620 2630 2640
1300 1310 1320 1330 1340 1350
pF1KF0 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
2650 2660 2670 2680 2690 2700
1360 1370 1380 1390 1400 1410
pF1KF0 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
2710 2720 2730 2740 2750 2760
1420 1430 1440 1450 1460 1470
pF1KF0 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
2770 2780 2790 2800 2810 2820
1480 1490 1500 1510 1520 1530
pF1KF0 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
2830 2840 2850 2860 2870 2880
1540 1550 1560 1570 1580 1590
pF1KF0 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
2890 2900 2910 2920 2930 2940
1600 1610 1620 1630 1640 1650
pF1KF0 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
2950 2960 2970 2980 2990 3000
1660 1670 1680 1690 1700 1710
pF1KF0 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
3010 3020 3030 3040 3050 3060
1720 1730 1740 1750 1760 1770
pF1KF0 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
3070 3080 3090 3100 3110 3120
1780 1790 1800 1810 1820
pF1KF0 TGSQDGMVRVWKTEDVKMSVPGLQMGRKREAAEALAQQCQAEGGRG---DWGLSSAYRRN
:::::::::::::::::::::: :.. : . . : . . . .: : .
XP_011 TGSQDGMVRVWKTEDVKMSVPGRPAGEEPPAQPPSPRGHKWEKNLALSRELDVSIALTGK
3130 3140 3150 3160 3170 3180
1830 1840 1850
pF1KF0 PQGLLPHSSQGRASGNHSSAAQPSPWPMGLL
:. : . .: ::.
XP_011 PSKTSPAVTALAVSRNHTKLLVGDERGRIFCWSADG
3190 3200 3210 3220
>>XP_011538289 (OMIM: 613316) PREDICTED: WD repeat- and (3217 aa)
initn: 11981 init1: 10321 opt: 11977 Z-score: 11261.2 bits: 2097.8 E(85289): 0
Smith-Waterman score: 11977; 97.1% identity (97.8% similar) in 1848 aa overlap (1-1845:1359-3199)
10 20 30
pF1KF0 MNISSRDNAMPVFLLRNCAGHLSGSLRTIG
::::::::::::::::::::::::::::::
XP_011 GLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIG
1330 1340 1350 1360 1370 1380
40 50 60 70 80 90
pF1KF0 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
1390 1400 1410 1420 1430 1440
100 110 120 130 140 150
pF1KF0 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
1450 1460 1470 1480 1490 1500
160 170 180 190 200 210
pF1KF0 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
1510 1520 1530 1540 1550 1560
220 230 240 250 260 270
pF1KF0 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
1570 1580 1590 1600 1610 1620
280 290 300 310 320 330
pF1KF0 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
1630 1640 1650 1660 1670 1680
340 350 360 370 380 390
pF1KF0 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
1690 1700 1710 1720 1730 1740
400 410 420 430 440 450
pF1KF0 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
1750 1760 1770 1780 1790 1800
460 470 480 490 500 510
pF1KF0 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
1810 1820 1830 1840 1850 1860
520 530 540 550 560 570
pF1KF0 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
1870 1880 1890 1900 1910 1920
580 590 600 610 620 630
pF1KF0 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
1930 1940 1950 1960 1970 1980
640 650 660 670 680 690
pF1KF0 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
1990 2000 2010 2020 2030 2040
700 710 720 730 740 750
pF1KF0 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
2050 2060 2070 2080 2090 2100
760 770 780 790 800 810
pF1KF0 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
2110 2120 2130 2140 2150 2160
820 830 840 850 860 870
pF1KF0 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
2170 2180 2190 2200 2210 2220
880 890 900 910 920 930
pF1KF0 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
2230 2240 2250 2260 2270 2280
940 950 960 970 980 990
pF1KF0 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
2290 2300 2310 2320 2330 2340
1000 1010 1020 1030 1040 1050
pF1KF0 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
2350 2360 2370 2380 2390 2400
1060 1070 1080 1090 1100 1110
pF1KF0 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
2410 2420 2430 2440 2450 2460
1120 1130 1140 1150 1160 1170
pF1KF0 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
2470 2480 2490 2500 2510 2520
1180 1190 1200 1210 1220 1230
pF1KF0 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLNLRRYPGSDRIMLQKWQKRDIS
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
XP_011 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQKRDIS
2530 2540 2550 2560 2570 2580
1240 1250 1260 1270 1280 1290
pF1KF0 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
2590 2600 2610 2620 2630 2640
1300 1310 1320 1330 1340 1350
pF1KF0 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
2650 2660 2670 2680 2690 2700
1360 1370 1380 1390 1400 1410
pF1KF0 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
2710 2720 2730 2740 2750 2760
1420 1430 1440 1450 1460 1470
pF1KF0 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
2770 2780 2790 2800 2810 2820
1480 1490 1500 1510 1520 1530
pF1KF0 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
2830 2840 2850 2860 2870 2880
1540 1550 1560 1570 1580 1590
pF1KF0 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
::::::::::::: ::::::::::::::::::::::::::::::::::::::::
XP_011 SLQSLRPSQVTVK-------GSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
2890 2900 2910 2920 2930 2940
1600 1610 1620 1630 1640 1650
pF1KF0 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
2950 2960 2970 2980 2990 3000
1660 1670 1680 1690 1700 1710
pF1KF0 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
3010 3020 3030 3040 3050 3060
1720 1730 1740 1750 1760 1770
pF1KF0 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
3070 3080 3090 3100 3110 3120
1780 1790 1800 1810 1820
pF1KF0 TGSQDGMVRVWKTEDVKMSVPGLQMGRKREAAEALAQQCQAEGGRG---DWGLSSAYRRN
:::::::::::::::::::::: :.. : . . : . . . .: : .
XP_011 TGSQDGMVRVWKTEDVKMSVPGRPAGEEPPAQPPSPRGHKWEKNLALSRELDVSIALTGK
3130 3140 3150 3160 3170 3180
1830 1840 1850
pF1KF0 PQGLLPHSSQGRASGNHSSAAQPSPWPMGLL
:. : . .: ::.
XP_011 PSKTSPAVTALAVSRNHTKLLVGDERGRIFCWSADG
3190 3200 3210
>>XP_011538292 (OMIM: 613316) PREDICTED: WD repeat- and (2435 aa)
initn: 7072 init1: 7072 opt: 7072 Z-score: 6648.5 bits: 1243.9 E(85289): 0
Smith-Waterman score: 7072; 100.0% identity (100.0% similar) in 1071 aa overlap (1-1071:1359-2429)
10 20 30
pF1KF0 MNISSRDNAMPVFLLRNCAGHLSGSLRTIG
::::::::::::::::::::::::::::::
XP_011 GLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIG
1330 1340 1350 1360 1370 1380
40 50 60 70 80 90
pF1KF0 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
1390 1400 1410 1420 1430 1440
100 110 120 130 140 150
pF1KF0 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
1450 1460 1470 1480 1490 1500
160 170 180 190 200 210
pF1KF0 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
1510 1520 1530 1540 1550 1560
220 230 240 250 260 270
pF1KF0 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
1570 1580 1590 1600 1610 1620
280 290 300 310 320 330
pF1KF0 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
1630 1640 1650 1660 1670 1680
340 350 360 370 380 390
pF1KF0 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
1690 1700 1710 1720 1730 1740
400 410 420 430 440 450
pF1KF0 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
1750 1760 1770 1780 1790 1800
460 470 480 490 500 510
pF1KF0 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
1810 1820 1830 1840 1850 1860
520 530 540 550 560 570
pF1KF0 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
1870 1880 1890 1900 1910 1920
580 590 600 610 620 630
pF1KF0 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
1930 1940 1950 1960 1970 1980
640 650 660 670 680 690
pF1KF0 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
1990 2000 2010 2020 2030 2040
700 710 720 730 740 750
pF1KF0 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
2050 2060 2070 2080 2090 2100
760 770 780 790 800 810
pF1KF0 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
2110 2120 2130 2140 2150 2160
820 830 840 850 860 870
pF1KF0 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
2170 2180 2190 2200 2210 2220
880 890 900 910 920 930
pF1KF0 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
2230 2240 2250 2260 2270 2280
940 950 960 970 980 990
pF1KF0 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
2290 2300 2310 2320 2330 2340
1000 1010 1020 1030 1040 1050
pF1KF0 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
2350 2360 2370 2380 2390 2400
1060 1070 1080 1090 1100 1110
pF1KF0 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
:::::::::::::::::::::
XP_011 DFLELCRERQVILQELLDKEKPQFSHL
2410 2420 2430
>>XP_011538293 (OMIM: 613316) PREDICTED: WD repeat- and (2045 aa)
initn: 4471 init1: 4426 opt: 4426 Z-score: 4160.4 bits: 783.2 E(85289): 0
Smith-Waterman score: 4426; 99.9% identity (100.0% similar) in 677 aa overlap (1-677:1359-2035)
10 20 30
pF1KF0 MNISSRDNAMPVFLLRNCAGHLSGSLRTIG
::::::::::::::::::::::::::::::
XP_011 GLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIG
1330 1340 1350 1360 1370 1380
40 50 60 70 80 90
pF1KF0 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
1390 1400 1410 1420 1430 1440
100 110 120 130 140 150
pF1KF0 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
1450 1460 1470 1480 1490 1500
160 170 180 190 200 210
pF1KF0 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
1510 1520 1530 1540 1550 1560
220 230 240 250 260 270
pF1KF0 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
1570 1580 1590 1600 1610 1620
280 290 300 310 320 330
pF1KF0 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
1630 1640 1650 1660 1670 1680
340 350 360 370 380 390
pF1KF0 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
1690 1700 1710 1720 1730 1740
400 410 420 430 440 450
pF1KF0 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
1750 1760 1770 1780 1790 1800
460 470 480 490 500 510
pF1KF0 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
1810 1820 1830 1840 1850 1860
520 530 540 550 560 570
pF1KF0 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
1870 1880 1890 1900 1910 1920
580 590 600 610 620 630
pF1KF0 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
1930 1940 1950 1960 1970 1980
640 650 660 670 680 690
pF1KF0 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
::::::::::::::::::::::::::::::::::::::::::::::.
XP_011 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVISAPLQARDFS
1990 2000 2010 2020 2030 2040
700 710 720 730 740 750
pF1KF0 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
>>XP_016871954 (OMIM: 613316) PREDICTED: WD repeat- and (1614 aa)
initn: 1908 init1: 1908 opt: 1908 Z-score: 1793.0 bits: 344.9 E(85289): 3.9e-93
Smith-Waterman score: 1908; 100.0% identity (100.0% similar) in 295 aa overlap (1-295:1319-1613)
10 20 30
pF1KF0 MNISSRDNAMPVFLLRNCAGHLSGSLRTIG
::::::::::::::::::::::::::::::
XP_016 GLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIG
1290 1300 1310 1320 1330 1340
40 50 60 70 80 90
pF1KF0 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
1350 1360 1370 1380 1390 1400
100 110 120 130 140 150
pF1KF0 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
1410 1420 1430 1440 1450 1460
160 170 180 190 200 210
pF1KF0 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
1470 1480 1490 1500 1510 1520
220 230 240 250 260 270
pF1KF0 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
1530 1540 1550 1560 1570 1580
280 290 300 310 320 330
pF1KF0 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
:::::::::::::::::::::::::
XP_016 IWLRNQLLEMLLSVISSPQLHLSSEQ
1590 1600 1610
1858 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 01:12:14 2016 done: Sat Nov 5 01:12:17 2016
Total Scan time: 18.360 Total Display time: 0.780
Function used was FASTA [36.3.4 Apr, 2011]