Result of FASTA (omim) for
pF1KF0175
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KF0175, 2119 aa
1>>>pF1KF0175 2119 - 2119 aa - 2119 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.3547+/-0.000431; mu= 10.8374+/- 0.027
mean_var=180.4253+/-37.860, 0's: 0 Z-trim(116.2): 94 B-trim: 0 in 0/58
Lambda= 0.095483
statistics sampled from 27128 (27228) to 27128 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.658), E-opt: 0.2 (0.319), width: 16
Scan time: 16.310
The best scores are: opt bits E(85289)
NP_001124459 (OMIM: 253601,254130,603009,606768) d (2119) 14565 2020.6 0
NP_001124453 (OMIM: 253601,254130,603009,606768) d (2118) 14396 1997.4 0
NP_001124449 (OMIM: 253601,254130,603009,606768) d (2087) 13325 1849.8 0
NP_001124456 (OMIM: 253601,254130,603009,606768) d (2088) 13325 1849.8 0
NP_001124450 (OMIM: 253601,254130,603009,606768) d (2101) 11020 1532.3 0
NP_001124455 (OMIM: 253601,254130,603009,606768) d (2102) 11020 1532.3 0
XP_005264642 (OMIM: 253601,254130,603009,606768) P (2132) 11020 1532.3 0
XP_005264641 (OMIM: 253601,254130,603009,606768) P (2133) 11020 1532.3 0
NP_001124457 (OMIM: 253601,254130,603009,606768) d (2098) 10180 1416.6 0
NP_001124452 (OMIM: 253601,254130,603009,606768) d (2097) 10011 1393.3 0
NP_001124448 (OMIM: 253601,254130,603009,606768) d (2066) 8940 1245.8 0
NP_001124458 (OMIM: 253601,254130,603009,606768) d (2067) 8940 1245.8 0
NP_003485 (OMIM: 253601,254130,603009,606768) dysf (2080) 6635 928.3 0
NP_001123927 (OMIM: 253601,254130,603009,606768) d (2081) 6635 928.3 0
NP_001124451 (OMIM: 253601,254130,603009,606768) d (2111) 6635 928.3 0
NP_001124454 (OMIM: 253601,254130,603009,606768) d (2112) 6635 928.3 0
XP_005269751 (OMIM: 604603) PREDICTED: myoferlin i (2067) 6075 851.1 0
XP_016871558 (OMIM: 604603) PREDICTED: myoferlin i (1938) 4815 677.5 3.9e-193
XP_016871557 (OMIM: 604603) PREDICTED: myoferlin i (1938) 4815 677.5 3.9e-193
XP_011537934 (OMIM: 604603) PREDICTED: myoferlin i (2062) 4815 677.5 4.1e-193
XP_005269750 (OMIM: 604603) PREDICTED: myoferlin i (2080) 4815 677.5 4.1e-193
NP_579899 (OMIM: 604603) myoferlin isoform b [Homo (2048) 4237 597.9 3.8e-169
XP_016871559 (OMIM: 604603) PREDICTED: myoferlin i (1786) 3322 471.8 3e-131
NP_038479 (OMIM: 604603) myoferlin isoform a [Homo (2061) 2977 424.4 6.7e-117
NP_004793 (OMIM: 601071,603681) otoferlin isoform (1230) 1667 243.7 9.4e-63
NP_919303 (OMIM: 601071,603681) otoferlin isoform (1307) 1667 243.8 9.8e-63
XP_016860827 (OMIM: 601071,603681) PREDICTED: otof (1977) 1667 243.9 1.4e-62
NP_919224 (OMIM: 601071,603681) otoferlin isoform (1997) 1667 243.9 1.4e-62
NP_919304 (OMIM: 601071,603681) otoferlin isoform (1230) 1641 240.2 1.1e-61
NP_001274418 (OMIM: 601071,603681) otoferlin isofo (1997) 1641 240.3 1.7e-61
>>NP_001124459 (OMIM: 253601,254130,603009,606768) dysfe (2119 aa)
initn: 14565 init1: 14565 opt: 14565 Z-score: 10846.5 bits: 2020.6 E(85289): 0
Smith-Waterman score: 14565; 100.0% identity (100.0% similar) in 2119 aa overlap (1-2119:1-2119)
10 20 30 40 50 60
pF1KF0 MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KF0 QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKKW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KF0 PAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KF0 SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KF0 NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KF0 FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KF0 EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KF0 PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCY
490 500 510 520 530 540
550 560 570 580 590 600
pF1KF0 INLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDLPADDILR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDLPADDILR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KF0 VEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVF
610 620 630 640 650 660
670 680 690 700 710 720
pF1KF0 DGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCST
670 680 690 700 710 720
730 740 750 760 770 780
pF1KF0 EDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGH
730 740 750 760 770 780
790 800 810 820 830 840
pF1KF0 SELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGAN
790 800 810 820 830 840
850 860 870 880 890 900
pF1KF0 YCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETY
850 860 870 880 890 900
910 920 930 940 950 960
pF1KF0 ENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDM
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KF0 DAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTD
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KF0 LNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KF0 EAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVMDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVMDD
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KF0 KSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KF0 HQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGR
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KF0 CICQPSLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CICQPSLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDES
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KF0 EDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECG
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KF0 GQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTI
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KF0 RSLESFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQLADGLSSLAPTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSLESFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQLADGLSSLAPTN
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KF0 TASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDF
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KF0 CNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVR
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KF0 IYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEK
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KF0 DLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQL
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KF0 LHLFCQQHRVKAPVYRTDRVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHLFCQQHRVKAPVYRTDRVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLV
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KF0 PEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTR
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KF0 DVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAE
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KF0 QVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKK
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KF0 CSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERP
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KF0 AGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLA
2050 2060 2070 2080 2090 2100
2110
pF1KF0 IFIYAFPNYAAMKLVKPFS
:::::::::::::::::::
NP_001 IFIYAFPNYAAMKLVKPFS
2110
>>NP_001124453 (OMIM: 253601,254130,603009,606768) dysfe (2118 aa)
initn: 14385 init1: 14385 opt: 14396 Z-score: 10720.7 bits: 1997.4 E(85289): 0
Smith-Waterman score: 14396; 99.0% identity (99.3% similar) in 2119 aa overlap (1-2119:1-2118)
10 20 30 40 50 60
pF1KF0 MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL
:: ... : :. . : :: : .: ::::::::::::::::::::::::::::::
NP_001 MLRVFILYAENVHTPDTDI-SDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL
10 20 30 40 50
70 80 90 100 110 120
pF1KF0 DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KF0 QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKKW
120 130 140 150 160 170
190 200 210 220 230 240
pF1KF0 PAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT
180 190 200 210 220 230
250 260 270 280 290 300
pF1KF0 SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF
240 250 260 270 280 290
310 320 330 340 350 360
pF1KF0 NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD
300 310 320 330 340 350
370 380 390 400 410 420
pF1KF0 FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA
360 370 380 390 400 410
430 440 450 460 470 480
pF1KF0 EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL
420 430 440 450 460 470
490 500 510 520 530 540
pF1KF0 PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCY
480 490 500 510 520 530
550 560 570 580 590 600
pF1KF0 INLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDLPADDILR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDLPADDILR
540 550 560 570 580 590
610 620 630 640 650 660
pF1KF0 VEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVF
600 610 620 630 640 650
670 680 690 700 710 720
pF1KF0 DGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCST
660 670 680 690 700 710
730 740 750 760 770 780
pF1KF0 EDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGH
720 730 740 750 760 770
790 800 810 820 830 840
pF1KF0 SELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGAN
780 790 800 810 820 830
850 860 870 880 890 900
pF1KF0 YCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETY
840 850 860 870 880 890
910 920 930 940 950 960
pF1KF0 ENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDM
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KF0 DAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTD
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KF0 LNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQA
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KF0 EAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVMDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVMDD
1080 1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KF0 KSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFL
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KF0 HQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGR
1200 1210 1220 1230 1240 1250
1270 1280 1290 1300 1310 1320
pF1KF0 CICQPSLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CICQPSLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDES
1260 1270 1280 1290 1300 1310
1330 1340 1350 1360 1370 1380
pF1KF0 EDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECG
1320 1330 1340 1350 1360 1370
1390 1400 1410 1420 1430 1440
pF1KF0 GQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTI
1380 1390 1400 1410 1420 1430
1450 1460 1470 1480 1490 1500
pF1KF0 RSLESFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQLADGLSSLAPTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSLESFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQLADGLSSLAPTN
1440 1450 1460 1470 1480 1490
1510 1520 1530 1540 1550 1560
pF1KF0 TASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDF
1500 1510 1520 1530 1540 1550
1570 1580 1590 1600 1610 1620
pF1KF0 CNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVR
1560 1570 1580 1590 1600 1610
1630 1640 1650 1660 1670 1680
pF1KF0 IYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEK
1620 1630 1640 1650 1660 1670
1690 1700 1710 1720 1730 1740
pF1KF0 DLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQL
1680 1690 1700 1710 1720 1730
1750 1760 1770 1780 1790 1800
pF1KF0 LHLFCQQHRVKAPVYRTDRVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHLFCQQHRVKAPVYRTDRVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLV
1740 1750 1760 1770 1780 1790
1810 1820 1830 1840 1850 1860
pF1KF0 PEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTR
1800 1810 1820 1830 1840 1850
1870 1880 1890 1900 1910 1920
pF1KF0 DVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAE
1860 1870 1880 1890 1900 1910
1930 1940 1950 1960 1970 1980
pF1KF0 QVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKK
1920 1930 1940 1950 1960 1970
1990 2000 2010 2020 2030 2040
pF1KF0 CSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERP
1980 1990 2000 2010 2020 2030
2050 2060 2070 2080 2090 2100
pF1KF0 AGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLA
2040 2050 2060 2070 2080 2090
2110
pF1KF0 IFIYAFPNYAAMKLVKPFS
:::::::::::::::::::
NP_001 IFIYAFPNYAAMKLVKPFS
2100 2110
>>NP_001124449 (OMIM: 253601,254130,603009,606768) dysfe (2087 aa)
initn: 13325 init1: 13325 opt: 13325 Z-score: 9923.4 bits: 1849.8 E(85289): 0
Smith-Waterman score: 14107; 97.5% identity (97.8% similar) in 2119 aa overlap (1-2119:1-2087)
10 20 30 40 50 60
pF1KF0 MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL
:: ... : :. . : :: : .: ::::::::::::::::::::::::::::::
NP_001 MLRVFILYAENVHTPDTDI-SDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL
10 20 30 40 50
70 80 90 100 110 120
pF1KF0 DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KF0 QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKKW
:::::::::::::::::::::::::::::::::
NP_001 QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVA---------------------------
120 130 140 150
190 200 210 220 230 240
pF1KF0 PAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ----DTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT
160 170 180 190 200
250 260 270 280 290 300
pF1KF0 SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF
210 220 230 240 250 260
310 320 330 340 350 360
pF1KF0 NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD
270 280 290 300 310 320
370 380 390 400 410 420
pF1KF0 FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA
330 340 350 360 370 380
430 440 450 460 470 480
pF1KF0 EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL
390 400 410 420 430 440
490 500 510 520 530 540
pF1KF0 PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCY
450 460 470 480 490 500
550 560 570 580 590 600
pF1KF0 INLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDLPADDILR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDLPADDILR
510 520 530 540 550 560
610 620 630 640 650 660
pF1KF0 VEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVF
570 580 590 600 610 620
670 680 690 700 710 720
pF1KF0 DGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCST
630 640 650 660 670 680
730 740 750 760 770 780
pF1KF0 EDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGH
690 700 710 720 730 740
790 800 810 820 830 840
pF1KF0 SELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGAN
750 760 770 780 790 800
850 860 870 880 890 900
pF1KF0 YCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETY
810 820 830 840 850 860
910 920 930 940 950 960
pF1KF0 ENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDM
870 880 890 900 910 920
970 980 990 1000 1010 1020
pF1KF0 DAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTD
930 940 950 960 970 980
1030 1040 1050 1060 1070 1080
pF1KF0 LNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQA
990 1000 1010 1020 1030 1040
1090 1100 1110 1120 1130 1140
pF1KF0 EAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVMDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVMDD
1050 1060 1070 1080 1090 1100
1150 1160 1170 1180 1190 1200
pF1KF0 KSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFL
1110 1120 1130 1140 1150 1160
1210 1220 1230 1240 1250 1260
pF1KF0 HQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGR
1170 1180 1190 1200 1210 1220
1270 1280 1290 1300 1310 1320
pF1KF0 CICQPSLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CICQPSLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDES
1230 1240 1250 1260 1270 1280
1330 1340 1350 1360 1370 1380
pF1KF0 EDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECG
1290 1300 1310 1320 1330 1340
1390 1400 1410 1420 1430 1440
pF1KF0 GQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTI
1350 1360 1370 1380 1390 1400
1450 1460 1470 1480 1490 1500
pF1KF0 RSLESFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQLADGLSSLAPTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSLESFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQLADGLSSLAPTN
1410 1420 1430 1440 1450 1460
1510 1520 1530 1540 1550 1560
pF1KF0 TASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDF
1470 1480 1490 1500 1510 1520
1570 1580 1590 1600 1610 1620
pF1KF0 CNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVR
1530 1540 1550 1560 1570 1580
1630 1640 1650 1660 1670 1680
pF1KF0 IYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEK
1590 1600 1610 1620 1630 1640
1690 1700 1710 1720 1730 1740
pF1KF0 DLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQL
1650 1660 1670 1680 1690 1700
1750 1760 1770 1780 1790 1800
pF1KF0 LHLFCQQHRVKAPVYRTDRVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHLFCQQHRVKAPVYRTDRVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLV
1710 1720 1730 1740 1750 1760
1810 1820 1830 1840 1850 1860
pF1KF0 PEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTR
1770 1780 1790 1800 1810 1820
1870 1880 1890 1900 1910 1920
pF1KF0 DVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAE
1830 1840 1850 1860 1870 1880
1930 1940 1950 1960 1970 1980
pF1KF0 QVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKK
1890 1900 1910 1920 1930 1940
1990 2000 2010 2020 2030 2040
pF1KF0 CSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERP
1950 1960 1970 1980 1990 2000
2050 2060 2070 2080 2090 2100
pF1KF0 AGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLA
2010 2020 2030 2040 2050 2060
2110
pF1KF0 IFIYAFPNYAAMKLVKPFS
:::::::::::::::::::
NP_001 IFIYAFPNYAAMKLVKPFS
2070 2080
>>NP_001124456 (OMIM: 253601,254130,603009,606768) dysfe (2088 aa)
initn: 13325 init1: 13325 opt: 13325 Z-score: 9923.4 bits: 1849.8 E(85289): 0
Smith-Waterman score: 14276; 98.5% identity (98.5% similar) in 2119 aa overlap (1-2119:1-2088)
10 20 30 40 50 60
pF1KF0 MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KF0 QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKKW
:::::::::::::::::::::::::::::::::
NP_001 QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVA---------------------------
130 140 150
190 200 210 220 230 240
pF1KF0 PAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ----DTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT
160 170 180 190 200
250 260 270 280 290 300
pF1KF0 SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF
210 220 230 240 250 260
310 320 330 340 350 360
pF1KF0 NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD
270 280 290 300 310 320
370 380 390 400 410 420
pF1KF0 FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA
330 340 350 360 370 380
430 440 450 460 470 480
pF1KF0 EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL
390 400 410 420 430 440
490 500 510 520 530 540
pF1KF0 PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCY
450 460 470 480 490 500
550 560 570 580 590 600
pF1KF0 INLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDLPADDILR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDLPADDILR
510 520 530 540 550 560
610 620 630 640 650 660
pF1KF0 VEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVF
570 580 590 600 610 620
670 680 690 700 710 720
pF1KF0 DGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCST
630 640 650 660 670 680
730 740 750 760 770 780
pF1KF0 EDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGH
690 700 710 720 730 740
790 800 810 820 830 840
pF1KF0 SELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGAN
750 760 770 780 790 800
850 860 870 880 890 900
pF1KF0 YCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETY
810 820 830 840 850 860
910 920 930 940 950 960
pF1KF0 ENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDM
870 880 890 900 910 920
970 980 990 1000 1010 1020
pF1KF0 DAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTD
930 940 950 960 970 980
1030 1040 1050 1060 1070 1080
pF1KF0 LNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQA
990 1000 1010 1020 1030 1040
1090 1100 1110 1120 1130 1140
pF1KF0 EAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVMDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVMDD
1050 1060 1070 1080 1090 1100
1150 1160 1170 1180 1190 1200
pF1KF0 KSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFL
1110 1120 1130 1140 1150 1160
1210 1220 1230 1240 1250 1260
pF1KF0 HQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGR
1170 1180 1190 1200 1210 1220
1270 1280 1290 1300 1310 1320
pF1KF0 CICQPSLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CICQPSLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDES
1230 1240 1250 1260 1270 1280
1330 1340 1350 1360 1370 1380
pF1KF0 EDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECG
1290 1300 1310 1320 1330 1340
1390 1400 1410 1420 1430 1440
pF1KF0 GQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTI
1350 1360 1370 1380 1390 1400
1450 1460 1470 1480 1490 1500
pF1KF0 RSLESFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQLADGLSSLAPTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSLESFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQLADGLSSLAPTN
1410 1420 1430 1440 1450 1460
1510 1520 1530 1540 1550 1560
pF1KF0 TASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDF
1470 1480 1490 1500 1510 1520
1570 1580 1590 1600 1610 1620
pF1KF0 CNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVR
1530 1540 1550 1560 1570 1580
1630 1640 1650 1660 1670 1680
pF1KF0 IYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEK
1590 1600 1610 1620 1630 1640
1690 1700 1710 1720 1730 1740
pF1KF0 DLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQL
1650 1660 1670 1680 1690 1700
1750 1760 1770 1780 1790 1800
pF1KF0 LHLFCQQHRVKAPVYRTDRVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHLFCQQHRVKAPVYRTDRVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLV
1710 1720 1730 1740 1750 1760
1810 1820 1830 1840 1850 1860
pF1KF0 PEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTR
1770 1780 1790 1800 1810 1820
1870 1880 1890 1900 1910 1920
pF1KF0 DVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAE
1830 1840 1850 1860 1870 1880
1930 1940 1950 1960 1970 1980
pF1KF0 QVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKK
1890 1900 1910 1920 1930 1940
1990 2000 2010 2020 2030 2040
pF1KF0 CSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERP
1950 1960 1970 1980 1990 2000
2050 2060 2070 2080 2090 2100
pF1KF0 AGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLA
2010 2020 2030 2040 2050 2060
2110
pF1KF0 IFIYAFPNYAAMKLVKPFS
:::::::::::::::::::
NP_001 IFIYAFPNYAAMKLVKPFS
2070 2080
>>NP_001124450 (OMIM: 253601,254130,603009,606768) dysfe (2101 aa)
initn: 11850 init1: 11016 opt: 11020 Z-score: 8207.4 bits: 1532.3 E(85289): 0
Smith-Waterman score: 14065; 96.9% identity (97.2% similar) in 2133 aa overlap (1-2119:1-2101)
10 20 30 40 50 60
pF1KF0 MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL
:: ... : :. . : :: : .: ::::::::::::::::::::::::::::::
NP_001 MLRVFILYAENVHTPDTDI-SDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL
10 20 30 40 50
70 80 90 100 110 120
pF1KF0 DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KF0 QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKKW
:::::::::::::::::::::::::::::::::
NP_001 QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVA---------------------------
120 130 140 150
190 200 210 220 230 240
pF1KF0 PAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ----DTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT
160 170 180 190 200
250 260 270 280 290 300
pF1KF0 SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF
210 220 230 240 250 260
310 320 330 340 350 360
pF1KF0 NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD
270 280 290 300 310 320
370 380 390 400 410 420
pF1KF0 FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA
330 340 350 360 370 380
430 440 450 460 470 480
pF1KF0 EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL
390 400 410 420 430 440
490 500 510 520
pF1KF0 PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIE--------------V
::::::::::::::::::::::::::::::::::::::::::::: .
NP_001 PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEEEPAGAVKPSKASDL
450 460 470 480 490 500
530 540 550 560 570 580
pF1KF0 DDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHS
510 520 530 540 550 560
590 600 610 620 630 640
pF1KF0 EQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTC
570 580 590 600 610 620
650 660 670 680 690 700
pF1KF0 LPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAG
630 640 650 660 670 680
710 720 730 740 750 760
pF1KF0 LEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHL
690 700 710 720 730 740
770 780 790 800 810 820
pF1KF0 SQITEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQITEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQR
750 760 770 780 790 800
830 840 850 860 870 880
pF1KF0 VPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFN
810 820 830 840 850 860
890 900 910 920 930 940
pF1KF0 QFAEGKLSVFAETYENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QFAEGKLSVFAETYENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAG
870 880 890 900 910 920
950 960 970 980 990 1000
pF1KF0 DWFVCPEKTLLHDMDAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DWFVCPEKTLLHDMDAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIEC
930 940 950 960 970 980
1010 1020 1030 1040 1050 1060
pF1KF0 PLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRR
990 1000 1010 1020 1030 1040
1070 1080 1090 1100 1110 1120
pF1KF0 DLSQMEALKRHRQAEAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLSQMEALKRHRQAEAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAA
1050 1060 1070 1080 1090 1100
1130 1140 1150 1160 1170 1180
pF1KF0 VFALEGALGGVMDDKSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFALEGALGGVMDDKSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMD
1110 1120 1130 1140 1150 1160
1190 1200 1210 1220 1230 1240
pF1KF0 KDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVEL
1170 1180 1190 1200 1210 1220
1250 1260 1270 1280 1290 1300
pF1KF0 YDHDTYGADEFMGRCICQPSLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YDHDTYGADEFMGRCICQPSLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIP
1230 1240 1250 1260 1270 1280
1310 1320 1330 1340 1350 1360
pF1KF0 GFEVQETSRILDESEDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFEVQETSRILDESEDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQ
1290 1300 1310 1320 1330 1340
1370 1380 1390 1400 1410 1420
pF1KF0 LANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDN
1350 1360 1370 1380 1390 1400
1430 1440 1450 1460 1470 1480
pF1KF0 RQFGRRPVVGQCTIRSLESFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQFGRRPVVGQCTIRSLESFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIP
1410 1420 1430 1440 1450 1460
1490 1500 1510 1520 1530 1540
pF1KF0 IQLADGLSSLAPTNTASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IQLADGLSSLAPTNTASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDT
1470 1480 1490 1500 1510 1520
1550 1560 1570 1580 1590 1600
pF1KF0 QLENVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLENVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQF
1530 1540 1550 1560 1570 1580
1610 1620 1630 1640 1650 1660
pF1KF0 HQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVF
1590 1600 1610 1620 1630 1640
1670 1680 1690 1700 1710 1720
pF1KF0 GKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVS
1650 1660 1670 1680 1690 1700
1730 1740 1750 1760 1770 1780
pF1KF0 GPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDRVMFQDKEYSIEEIEAGRIPNPHLGPVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDRVMFQDKEYSIEEIEAGRIPNPHLGPVE
1710 1720 1730 1740 1750 1760
1790 1800 1810 1820 1830 1840
pF1KF0 ERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRR
1770 1780 1790 1800 1810 1820
1850 1860 1870 1880 1890 1900
pF1KF0 ARRFFLRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARRFFLRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNF
1830 1840 1850 1860 1870 1880
1910 1920 1930 1940 1950 1960
pF1KF0 NWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQL
1890 1900 1910 1920 1930 1940
1970 1980 1990 2000 2010 2020
pF1KF0 DLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEM
1950 1960 1970 1980 1990 2000
2030 2040 2050 2060 2070 2080
pF1KF0 TLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAI
2010 2020 2030 2040 2050 2060
2090 2100 2110
pF1KF0 ILFIILFILLLFLAIFIYAFPNYAAMKLVKPFS
:::::::::::::::::::::::::::::::::
NP_001 ILFIILFILLLFLAIFIYAFPNYAAMKLVKPFS
2070 2080 2090 2100
>>NP_001124455 (OMIM: 253601,254130,603009,606768) dysfe (2102 aa)
initn: 12030 init1: 11016 opt: 11020 Z-score: 8207.4 bits: 1532.3 E(85289): 0
Smith-Waterman score: 14234; 97.8% identity (97.9% similar) in 2133 aa overlap (1-2119:1-2102)
10 20 30 40 50 60
pF1KF0 MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KF0 QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKKW
:::::::::::::::::::::::::::::::::
NP_001 QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVA---------------------------
130 140 150
190 200 210 220 230 240
pF1KF0 PAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ----DTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT
160 170 180 190 200
250 260 270 280 290 300
pF1KF0 SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF
210 220 230 240 250 260
310 320 330 340 350 360
pF1KF0 NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD
270 280 290 300 310 320
370 380 390 400 410 420
pF1KF0 FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA
330 340 350 360 370 380
430 440 450 460 470 480
pF1KF0 EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL
390 400 410 420 430 440
490 500 510 520
pF1KF0 PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIE--------------V
::::::::::::::::::::::::::::::::::::::::::::: .
NP_001 PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEEEPAGAVKPSKASDL
450 460 470 480 490 500
530 540 550 560 570 580
pF1KF0 DDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHS
510 520 530 540 550 560
590 600 610 620 630 640
pF1KF0 EQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTC
570 580 590 600 610 620
650 660 670 680 690 700
pF1KF0 LPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAG
630 640 650 660 670 680
710 720 730 740 750 760
pF1KF0 LEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHL
690 700 710 720 730 740
770 780 790 800 810 820
pF1KF0 SQITEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQITEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQR
750 760 770 780 790 800
830 840 850 860 870 880
pF1KF0 VPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFN
810 820 830 840 850 860
890 900 910 920 930 940
pF1KF0 QFAEGKLSVFAETYENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QFAEGKLSVFAETYENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAG
870 880 890 900 910 920
950 960 970 980 990 1000
pF1KF0 DWFVCPEKTLLHDMDAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DWFVCPEKTLLHDMDAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIEC
930 940 950 960 970 980
1010 1020 1030 1040 1050 1060
pF1KF0 PLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRR
990 1000 1010 1020 1030 1040
1070 1080 1090 1100 1110 1120
pF1KF0 DLSQMEALKRHRQAEAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLSQMEALKRHRQAEAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAA
1050 1060 1070 1080 1090 1100
1130 1140 1150 1160 1170 1180
pF1KF0 VFALEGALGGVMDDKSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFALEGALGGVMDDKSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMD
1110 1120 1130 1140 1150 1160
1190 1200 1210 1220 1230 1240
pF1KF0 KDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVEL
1170 1180 1190 1200 1210 1220
1250 1260 1270 1280 1290 1300
pF1KF0 YDHDTYGADEFMGRCICQPSLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YDHDTYGADEFMGRCICQPSLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIP
1230 1240 1250 1260 1270 1280
1310 1320 1330 1340 1350 1360
pF1KF0 GFEVQETSRILDESEDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFEVQETSRILDESEDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQ
1290 1300 1310 1320 1330 1340
1370 1380 1390 1400 1410 1420
pF1KF0 LANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDN
1350 1360 1370 1380 1390 1400
1430 1440 1450 1460 1470 1480
pF1KF0 RQFGRRPVVGQCTIRSLESFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQFGRRPVVGQCTIRSLESFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIP
1410 1420 1430 1440 1450 1460
1490 1500 1510 1520 1530 1540
pF1KF0 IQLADGLSSLAPTNTASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IQLADGLSSLAPTNTASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDT
1470 1480 1490 1500 1510 1520
1550 1560 1570 1580 1590 1600
pF1KF0 QLENVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLENVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQF
1530 1540 1550 1560 1570 1580
1610 1620 1630 1640 1650 1660
pF1KF0 HQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVF
1590 1600 1610 1620 1630 1640
1670 1680 1690 1700 1710 1720
pF1KF0 GKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVS
1650 1660 1670 1680 1690 1700
1730 1740 1750 1760 1770 1780
pF1KF0 GPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDRVMFQDKEYSIEEIEAGRIPNPHLGPVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDRVMFQDKEYSIEEIEAGRIPNPHLGPVE
1710 1720 1730 1740 1750 1760
1790 1800 1810 1820 1830 1840
pF1KF0 ERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRR
1770 1780 1790 1800 1810 1820
1850 1860 1870 1880 1890 1900
pF1KF0 ARRFFLRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARRFFLRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNF
1830 1840 1850 1860 1870 1880
1910 1920 1930 1940 1950 1960
pF1KF0 NWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQL
1890 1900 1910 1920 1930 1940
1970 1980 1990 2000 2010 2020
pF1KF0 DLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEM
1950 1960 1970 1980 1990 2000
2030 2040 2050 2060 2070 2080
pF1KF0 TLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAI
2010 2020 2030 2040 2050 2060
2090 2100 2110
pF1KF0 ILFIILFILLLFLAIFIYAFPNYAAMKLVKPFS
:::::::::::::::::::::::::::::::::
NP_001 ILFIILFILLLFLAIFIYAFPNYAAMKLVKPFS
2070 2080 2090 2100
>>XP_005264642 (OMIM: 253601,254130,603009,606768) PREDI (2132 aa)
initn: 11016 init1: 11016 opt: 11020 Z-score: 8207.3 bits: 1532.3 E(85289): 0
Smith-Waterman score: 14354; 98.3% identity (98.6% similar) in 2133 aa overlap (1-2119:1-2132)
10 20 30 40 50 60
pF1KF0 MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL
:: ... : :. . : :: : .: ::::::::::::::::::::::::::::::
XP_005 MLRVFILYAENVHTPDTDI-SDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL
10 20 30 40 50
70 80 90 100 110 120
pF1KF0 DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KF0 QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKKW
120 130 140 150 160 170
190 200 210 220 230 240
pF1KF0 PAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT
180 190 200 210 220 230
250 260 270 280 290 300
pF1KF0 SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF
240 250 260 270 280 290
310 320 330 340 350 360
pF1KF0 NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD
300 310 320 330 340 350
370 380 390 400 410 420
pF1KF0 FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA
360 370 380 390 400 410
430 440 450 460 470 480
pF1KF0 EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL
420 430 440 450 460 470
490 500 510 520
pF1KF0 PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIE--------------V
::::::::::::::::::::::::::::::::::::::::::::: .
XP_005 PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEEEPAGAVKPSKASDL
480 490 500 510 520 530
530 540 550 560 570 580
pF1KF0 DDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHS
540 550 560 570 580 590
590 600 610 620 630 640
pF1KF0 EQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTC
600 610 620 630 640 650
650 660 670 680 690 700
pF1KF0 LPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAG
660 670 680 690 700 710
710 720 730 740 750 760
pF1KF0 LEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHL
720 730 740 750 760 770
770 780 790 800 810 820
pF1KF0 SQITEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SQITEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQR
780 790 800 810 820 830
830 840 850 860 870 880
pF1KF0 VPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFN
840 850 860 870 880 890
890 900 910 920 930 940
pF1KF0 QFAEGKLSVFAETYENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QFAEGKLSVFAETYENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAG
900 910 920 930 940 950
950 960 970 980 990 1000
pF1KF0 DWFVCPEKTLLHDMDAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DWFVCPEKTLLHDMDAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIEC
960 970 980 990 1000 1010
1010 1020 1030 1040 1050 1060
pF1KF0 PLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRR
1020 1030 1040 1050 1060 1070
1070 1080 1090 1100 1110 1120
pF1KF0 DLSQMEALKRHRQAEAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLSQMEALKRHRQAEAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAA
1080 1090 1100 1110 1120 1130
1130 1140 1150 1160 1170 1180
pF1KF0 VFALEGALGGVMDDKSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VFALEGALGGVMDDKSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMD
1140 1150 1160 1170 1180 1190
1190 1200 1210 1220 1230 1240
pF1KF0 KDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVEL
1200 1210 1220 1230 1240 1250
1250 1260 1270 1280 1290 1300
pF1KF0 YDHDTYGADEFMGRCICQPSLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YDHDTYGADEFMGRCICQPSLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIP
1260 1270 1280 1290 1300 1310
1310 1320 1330 1340 1350 1360
pF1KF0 GFEVQETSRILDESEDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GFEVQETSRILDESEDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQ
1320 1330 1340 1350 1360 1370
1370 1380 1390 1400 1410 1420
pF1KF0 LANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDN
1380 1390 1400 1410 1420 1430
1430 1440 1450 1460 1470 1480
pF1KF0 RQFGRRPVVGQCTIRSLESFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RQFGRRPVVGQCTIRSLESFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIP
1440 1450 1460 1470 1480 1490
1490 1500 1510 1520 1530 1540
pF1KF0 IQLADGLSSLAPTNTASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IQLADGLSSLAPTNTASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDT
1500 1510 1520 1530 1540 1550
1550 1560 1570 1580 1590 1600
pF1KF0 QLENVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLENVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQF
1560 1570 1580 1590 1600 1610
1610 1620 1630 1640 1650 1660
pF1KF0 HQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVF
1620 1630 1640 1650 1660 1670
1670 1680 1690 1700 1710 1720
pF1KF0 GKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVS
1680 1690 1700 1710 1720 1730
1730 1740 1750 1760 1770 1780
pF1KF0 GPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDRVMFQDKEYSIEEIEAGRIPNPHLGPVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDRVMFQDKEYSIEEIEAGRIPNPHLGPVE
1740 1750 1760 1770 1780 1790
1790 1800 1810 1820 1830 1840
pF1KF0 ERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRR
1800 1810 1820 1830 1840 1850
1850 1860 1870 1880 1890 1900
pF1KF0 ARRFFLRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARRFFLRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNF
1860 1870 1880 1890 1900 1910
1910 1920 1930 1940 1950 1960
pF1KF0 NWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQL
1920 1930 1940 1950 1960 1970
1970 1980 1990 2000 2010 2020
pF1KF0 DLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEM
1980 1990 2000 2010 2020 2030
2030 2040 2050 2060 2070 2080
pF1KF0 TLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAI
2040 2050 2060 2070 2080 2090
2090 2100 2110
pF1KF0 ILFIILFILLLFLAIFIYAFPNYAAMKLVKPFS
:::::::::::::::::::::::::::::::::
XP_005 ILFIILFILLLFLAIFIYAFPNYAAMKLVKPFS
2100 2110 2120 2130
>>XP_005264641 (OMIM: 253601,254130,603009,606768) PREDI (2133 aa)
initn: 11016 init1: 11016 opt: 11020 Z-score: 8207.3 bits: 1532.3 E(85289): 0
Smith-Waterman score: 14523; 99.3% identity (99.3% similar) in 2133 aa overlap (1-2119:1-2133)
10 20 30 40 50 60
pF1KF0 MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KF0 QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKKW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KF0 PAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KF0 SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KF0 NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KF0 FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KF0 EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL
430 440 450 460 470 480
490 500 510 520
pF1KF0 PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIE--------------V
::::::::::::::::::::::::::::::::::::::::::::: .
XP_005 PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEEEPAGAVKPSKASDL
490 500 510 520 530 540
530 540 550 560 570 580
pF1KF0 DDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHS
550 560 570 580 590 600
590 600 610 620 630 640
pF1KF0 EQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTC
610 620 630 640 650 660
650 660 670 680 690 700
pF1KF0 LPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAG
670 680 690 700 710 720
710 720 730 740 750 760
pF1KF0 LEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHL
730 740 750 760 770 780
770 780 790 800 810 820
pF1KF0 SQITEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SQITEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQR
790 800 810 820 830 840
830 840 850 860 870 880
pF1KF0 VPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFN
850 860 870 880 890 900
890 900 910 920 930 940
pF1KF0 QFAEGKLSVFAETYENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QFAEGKLSVFAETYENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAG
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KF0 DWFVCPEKTLLHDMDAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DWFVCPEKTLLHDMDAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIEC
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KF0 PLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRR
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KF0 DLSQMEALKRHRQAEAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLSQMEALKRHRQAEAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAA
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KF0 VFALEGALGGVMDDKSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VFALEGALGGVMDDKSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMD
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KF0 KDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVEL
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280 1290 1300
pF1KF0 YDHDTYGADEFMGRCICQPSLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YDHDTYGADEFMGRCICQPSLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIP
1270 1280 1290 1300 1310 1320
1310 1320 1330 1340 1350 1360
pF1KF0 GFEVQETSRILDESEDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GFEVQETSRILDESEDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQ
1330 1340 1350 1360 1370 1380
1370 1380 1390 1400 1410 1420
pF1KF0 LANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDN
1390 1400 1410 1420 1430 1440
1430 1440 1450 1460 1470 1480
pF1KF0 RQFGRRPVVGQCTIRSLESFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RQFGRRPVVGQCTIRSLESFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIP
1450 1460 1470 1480 1490 1500
1490 1500 1510 1520 1530 1540
pF1KF0 IQLADGLSSLAPTNTASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IQLADGLSSLAPTNTASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDT
1510 1520 1530 1540 1550 1560
1550 1560 1570 1580 1590 1600
pF1KF0 QLENVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLENVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQF
1570 1580 1590 1600 1610 1620
1610 1620 1630 1640 1650 1660
pF1KF0 HQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVF
1630 1640 1650 1660 1670 1680
1670 1680 1690 1700 1710 1720
pF1KF0 GKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVS
1690 1700 1710 1720 1730 1740
1730 1740 1750 1760 1770 1780
pF1KF0 GPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDRVMFQDKEYSIEEIEAGRIPNPHLGPVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDRVMFQDKEYSIEEIEAGRIPNPHLGPVE
1750 1760 1770 1780 1790 1800
1790 1800 1810 1820 1830 1840
pF1KF0 ERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRR
1810 1820 1830 1840 1850 1860
1850 1860 1870 1880 1890 1900
pF1KF0 ARRFFLRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARRFFLRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNF
1870 1880 1890 1900 1910 1920
1910 1920 1930 1940 1950 1960
pF1KF0 NWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQL
1930 1940 1950 1960 1970 1980
1970 1980 1990 2000 2010 2020
pF1KF0 DLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLNRMPKPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEM
1990 2000 2010 2020 2030 2040
2030 2040 2050 2060 2070 2080
pF1KF0 TLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAI
2050 2060 2070 2080 2090 2100
2090 2100 2110
pF1KF0 ILFIILFILLLFLAIFIYAFPNYAAMKLVKPFS
:::::::::::::::::::::::::::::::::
XP_005 ILFIILFILLLFLAIFIYAFPNYAAMKLVKPFS
2110 2120 2130
>>NP_001124457 (OMIM: 253601,254130,603009,606768) dysfe (2098 aa)
initn: 10170 init1: 10170 opt: 10180 Z-score: 7582.0 bits: 1416.6 E(85289): 0
Smith-Waterman score: 14375; 99.0% identity (99.0% similar) in 2119 aa overlap (1-2119:1-2098)
10 20 30 40 50 60
pF1KF0 MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KF0 QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKKW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KF0 PAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KF0 SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KF0 NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KF0 FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KF0 EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KF0 PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCY
490 500 510 520 530 540
550 560 570 580 590 600
pF1KF0 INLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDLPADDILR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDLPADDILR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KF0 VEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVF
610 620 630 640 650 660
670 680 690 700 710 720
pF1KF0 DGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCST
670 680 690 700 710 720
730 740 750 760 770 780
pF1KF0 EDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGH
730 740 750 760 770 780
790 800 810 820 830 840
pF1KF0 SELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGAN
790 800 810 820 830 840
850 860 870 880 890 900
pF1KF0 YCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETY
850 860 870 880 890 900
910 920 930 940 950 960
pF1KF0 ENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDM
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KF0 DAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTD
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KF0 LNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KF0 EAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVMDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVMDD
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KF0 KSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KF0 HQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGR
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KF0 CICQPSLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CICQPSLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDES
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KF0 EDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECG
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KF0 GQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTI
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KF0 RSLESFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQLADGLSSLAPTN
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSLESFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQ------------
1450 1460 1470 1480
1510 1520 1530 1540 1550 1560
pF1KF0 TASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDF
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ---------EEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDF
1490 1500 1510 1520 1530
1570 1580 1590 1600 1610 1620
pF1KF0 CNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVR
1540 1550 1560 1570 1580 1590
1630 1640 1650 1660 1670 1680
pF1KF0 IYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEK
1600 1610 1620 1630 1640 1650
1690 1700 1710 1720 1730 1740
pF1KF0 DLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQL
1660 1670 1680 1690 1700 1710
1750 1760 1770 1780 1790 1800
pF1KF0 LHLFCQQHRVKAPVYRTDRVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHLFCQQHRVKAPVYRTDRVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLV
1720 1730 1740 1750 1760 1770
1810 1820 1830 1840 1850 1860
pF1KF0 PEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTR
1780 1790 1800 1810 1820 1830
1870 1880 1890 1900 1910 1920
pF1KF0 DVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAE
1840 1850 1860 1870 1880 1890
1930 1940 1950 1960 1970 1980
pF1KF0 QVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKK
1900 1910 1920 1930 1940 1950
1990 2000 2010 2020 2030 2040
pF1KF0 CSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERP
1960 1970 1980 1990 2000 2010
2050 2060 2070 2080 2090 2100
pF1KF0 AGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLA
2020 2030 2040 2050 2060 2070
2110
pF1KF0 IFIYAFPNYAAMKLVKPFS
:::::::::::::::::::
NP_001 IFIYAFPNYAAMKLVKPFS
2080 2090
>>NP_001124452 (OMIM: 253601,254130,603009,606768) dysfe (2097 aa)
initn: 9990 init1: 9990 opt: 10011 Z-score: 7456.2 bits: 1393.3 E(85289): 0
Smith-Waterman score: 14206; 98.0% identity (98.3% similar) in 2119 aa overlap (1-2119:1-2097)
10 20 30 40 50 60
pF1KF0 MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL
:: ... : :. . : :: : .: ::::::::::::::::::::::::::::::
NP_001 MLRVFILYAENVHTPDTDI-SDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL
10 20 30 40 50
70 80 90 100 110 120
pF1KF0 DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQPTGASLVL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KF0 QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKKW
120 130 140 150 160 170
190 200 210 220 230 240
pF1KF0 PAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT
180 190 200 210 220 230
250 260 270 280 290 300
pF1KF0 SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF
240 250 260 270 280 290
310 320 330 340 350 360
pF1KF0 NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD
300 310 320 330 340 350
370 380 390 400 410 420
pF1KF0 FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA
360 370 380 390 400 410
430 440 450 460 470 480
pF1KF0 EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL
420 430 440 450 460 470
490 500 510 520 530 540
pF1KF0 PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCY
480 490 500 510 520 530
550 560 570 580 590 600
pF1KF0 INLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDLPADDILR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQKVEDLPADDILR
540 550 560 570 580 590
610 620 630 640 650 660
pF1KF0 VEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVF
600 610 620 630 640 650
670 680 690 700 710 720
pF1KF0 DGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCST
660 670 680 690 700 710
730 740 750 760 770 780
pF1KF0 EDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGH
720 730 740 750 760 770
790 800 810 820 830 840
pF1KF0 SELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGAN
780 790 800 810 820 830
850 860 870 880 890 900
pF1KF0 YCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETY
840 850 860 870 880 890
910 920 930 940 950 960
pF1KF0 ENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENETKLALVGNWGTTGLTYPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDM
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KF0 DAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTD
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KF0 LNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQA
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KF0 EAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVMDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAEGEGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVMDD
1080 1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KF0 KSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSEDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFL
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KF0 HQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGR
1200 1210 1220 1230 1240 1250
1270 1280 1290 1300 1310 1320
pF1KF0 CICQPSLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CICQPSLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDES
1260 1270 1280 1290 1300 1310
1330 1340 1350 1360 1370 1380
pF1KF0 EDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECG
1320 1330 1340 1350 1360 1370
1390 1400 1410 1420 1430 1440
pF1KF0 GQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTI
1380 1390 1400 1410 1420 1430
1450 1460 1470 1480 1490 1500
pF1KF0 RSLESFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQLADGLSSLAPTN
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSLESFLCDPYSAESPSPQGGPDDVSLLSPGEDVLIDIDDKEPLIPIQ------------
1440 1450 1460 1470 1480
1510 1520 1530 1540 1550 1560
pF1KF0 TASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDF
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ---------EEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDF
1490 1500 1510 1520 1530
1570 1580 1590 1600 1610 1620
pF1KF0 CNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVR
1540 1550 1560 1570 1580 1590
1630 1640 1650 1660 1670 1680
pF1KF0 IYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEK
1600 1610 1620 1630 1640 1650
1690 1700 1710 1720 1730 1740
pF1KF0 DLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQL
1660 1670 1680 1690 1700 1710
1750 1760 1770 1780 1790 1800
pF1KF0 LHLFCQQHRVKAPVYRTDRVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHLFCQQHRVKAPVYRTDRVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLV
1720 1730 1740 1750 1760 1770
1810 1820 1830 1840 1850 1860
pF1KF0 PEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTR
1780 1790 1800 1810 1820 1830
1870 1880 1890 1900 1910 1920
pF1KF0 DVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAE
1840 1850 1860 1870 1880 1890
1930 1940 1950 1960 1970 1980
pF1KF0 QVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKK
1900 1910 1920 1930 1940 1950
1990 2000 2010 2020 2030 2040
pF1KF0 CSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSLDQLDDAFHPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERP
1960 1970 1980 1990 2000 2010
2050 2060 2070 2080 2090 2100
pF1KF0 AGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLA
2020 2030 2040 2050 2060 2070
2110
pF1KF0 IFIYAFPNYAAMKLVKPFS
:::::::::::::::::::
NP_001 IFIYAFPNYAAMKLVKPFS
2080 2090
2119 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 23:31:34 2016 done: Fri Nov 4 23:31:36 2016
Total Scan time: 16.310 Total Display time: 1.600
Function used was FASTA [36.3.4 Apr, 2011]