FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KF0190, 520 aa 1>>>pF1KF0190 520 - 520 aa - 520 aa Library: /omim/omim.rfq.tfa 64092750 residues in 91774 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.5734+/-0.000269; mu= 9.0551+/- 0.017 mean_var=152.7666+/-30.561, 0's: 0 Z-trim(123.3): 21 B-trim: 379 in 1/54 Lambda= 0.103767 statistics sampled from 44521 (44543) to 44521 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.8), E-opt: 0.2 (0.485), width: 16 Scan time: 5.790 The best scores are: opt bits E(91774) NP_734464 (OMIM: 607404) interferon lambda recepto ( 520) 3631 555.1 2e-157 XP_006710457 (OMIM: 607404) interferon lambda rece ( 489) 3200 490.5 5.1e-138 XP_016855968 (OMIM: 607404) interferon lambda rece ( 437) 3043 467.0 5.6e-131 NP_775087 (OMIM: 607404) interferon lambda recepto ( 491) 1872 291.7 3.6e-78 XP_024309436 (OMIM: 607404) interferon lambda rece ( 319) 1791 279.4 1.2e-74 NP_775088 (OMIM: 607404) interferon lambda recepto ( 244) 1555 244.0 4e-64 NP_851826 (OMIM: 606648) interleukin-22 receptor s ( 231) 227 45.2 0.00027 XP_016866443 (OMIM: 605620) interleukin-20 recepto ( 554) 206 42.3 0.0048 NP_851827 (OMIM: 606648) interleukin-22 receptor s ( 130) 194 40.1 0.0053 NP_000619 (OMIM: 123889,610424,612567) interleukin ( 325) 199 41.1 0.0065 >>NP_734464 (OMIM: 607404) interferon lambda receptor 1 (520 aa) initn: 3631 init1: 3631 opt: 3631 Z-score: 2947.7 bits: 555.1 E(91774): 2e-157 Smith-Waterman score: 3631; 100.0% identity (100.0% similar) in 520 aa overlap (1-520:1-520) 10 20 30 40 50 60 pF1KF0 MAGPERWGPLLLCLLQAAPGRPRLAPPQNVTLLSQNFSVYLTWLPGLGNPQDVTYFVAYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_734 MAGPERWGPLLLCLLQAAPGRPRLAPPQNVTLLSQNFSVYLTWLPGLGNPQDVTYFVAYQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KF0 SSPTRRRWREVEECAGTKELLCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVESEYLDYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_734 SSPTRRRWREVEECAGTKELLCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVESEYLDYL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KF0 FEVEPAPPVLVLTQTEEILSANATYQLPPCMPPLDLKYEVAFWKEGAGNKTLFPVTPHGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_734 FEVEPAPPVLVLTQTEEILSANATYQLPPCMPPLDLKYEVAFWKEGAGNKTLFPVTPHGQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KF0 PVQITLQPAASEHHCLSARTIYTFSVPKYSKFSKPTCFLLEVPEANWAFLVLPSLLILLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_734 PVQITLQPAASEHHCLSARTIYTFSVPKYSKFSKPTCFLLEVPEANWAFLVLPSLLILLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KF0 VIAAGGVIWKTLMGNPWFQRAKMPRALDFSGHTHPVATFQPSRPESVNDLFLCPQKELTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_734 VIAAGGVIWKTLMGNPWFQRAKMPRALDFSGHTHPVATFQPSRPESVNDLFLCPQKELTR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KF0 GVRPTPRVRAPATQQTRWKKDLAEDEEEEDEEDTEDGVSFQPYIEPPSFLGQEHQAPGHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_734 GVRPTPRVRAPATQQTRWKKDLAEDEEEEDEEDTEDGVSFQPYIEPPSFLGQEHQAPGHS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KF0 EAGGVDSGRPRAPLVPSEGSSAWDSSDRSWASTVDSSWDRAGSSGYLAEKGPGQGPGGDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_734 EAGGVDSGRPRAPLVPSEGSSAWDSSDRSWASTVDSSWDRAGSSGYLAEKGPGQGPGGDG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KF0 HQESLPPPEFSKDSGFLEELPEDNLSSWATWGTLPPEPNLVPGGPPVSLQTLTFCWESSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_734 HQESLPPPEFSKDSGFLEELPEDNLSSWATWGTLPPEPNLVPGGPPVSLQTLTFCWESSP 430 440 450 460 470 480 490 500 510 520 pF1KF0 EEEEEARESEIEDSDAGSWGAESTQRTEDRGRTLGHYMAR :::::::::::::::::::::::::::::::::::::::: NP_734 EEEEEARESEIEDSDAGSWGAESTQRTEDRGRTLGHYMAR 490 500 510 520 >>XP_006710457 (OMIM: 607404) interferon lambda receptor (489 aa) initn: 3200 init1: 3200 opt: 3200 Z-score: 2599.4 bits: 490.5 E(91774): 5.1e-138 Smith-Waterman score: 3200; 100.0% identity (100.0% similar) in 459 aa overlap (62-520:31-489) 40 50 60 70 80 90 pF1KF0 LLSQNFSVYLTWLPGLGNPQDVTYFVAYQSSPTRRRWREVEECAGTKELLCSMMCLKKQD :::::::::::::::::::::::::::::: XP_006 MEPEGELGSDSNICALPVASRHPSMCGIHISPTRRRWREVEECAGTKELLCSMMCLKKQD 10 20 30 40 50 60 100 110 120 130 140 150 pF1KF0 LYNKFKGRVRTVSPSSKSPWVESEYLDYLFEVEPAPPVLVLTQTEEILSANATYQLPPCM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LYNKFKGRVRTVSPSSKSPWVESEYLDYLFEVEPAPPVLVLTQTEEILSANATYQLPPCM 70 80 90 100 110 120 160 170 180 190 200 210 pF1KF0 PPLDLKYEVAFWKEGAGNKTLFPVTPHGQPVQITLQPAASEHHCLSARTIYTFSVPKYSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PPLDLKYEVAFWKEGAGNKTLFPVTPHGQPVQITLQPAASEHHCLSARTIYTFSVPKYSK 130 140 150 160 170 180 220 230 240 250 260 270 pF1KF0 FSKPTCFLLEVPEANWAFLVLPSLLILLLVIAAGGVIWKTLMGNPWFQRAKMPRALDFSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FSKPTCFLLEVPEANWAFLVLPSLLILLLVIAAGGVIWKTLMGNPWFQRAKMPRALDFSG 190 200 210 220 230 240 280 290 300 310 320 330 pF1KF0 HTHPVATFQPSRPESVNDLFLCPQKELTRGVRPTPRVRAPATQQTRWKKDLAEDEEEEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HTHPVATFQPSRPESVNDLFLCPQKELTRGVRPTPRVRAPATQQTRWKKDLAEDEEEEDE 250 260 270 280 290 300 340 350 360 370 380 390 pF1KF0 EDTEDGVSFQPYIEPPSFLGQEHQAPGHSEAGGVDSGRPRAPLVPSEGSSAWDSSDRSWA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EDTEDGVSFQPYIEPPSFLGQEHQAPGHSEAGGVDSGRPRAPLVPSEGSSAWDSSDRSWA 310 320 330 340 350 360 400 410 420 430 440 450 pF1KF0 STVDSSWDRAGSSGYLAEKGPGQGPGGDGHQESLPPPEFSKDSGFLEELPEDNLSSWATW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 STVDSSWDRAGSSGYLAEKGPGQGPGGDGHQESLPPPEFSKDSGFLEELPEDNLSSWATW 370 380 390 400 410 420 460 470 480 490 500 510 pF1KF0 GTLPPEPNLVPGGPPVSLQTLTFCWESSPEEEEEARESEIEDSDAGSWGAESTQRTEDRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GTLPPEPNLVPGGPPVSLQTLTFCWESSPEEEEEARESEIEDSDAGSWGAESTQRTEDRG 430 440 450 460 470 480 520 pF1KF0 RTLGHYMAR ::::::::: XP_006 RTLGHYMAR >>XP_016855968 (OMIM: 607404) interferon lambda receptor (437 aa) initn: 3043 init1: 3043 opt: 3043 Z-score: 2473.1 bits: 467.0 E(91774): 5.6e-131 Smith-Waterman score: 3043; 100.0% identity (100.0% similar) in 437 aa overlap (84-520:1-437) 60 70 80 90 100 110 pF1KF0 TYFVAYQSSPTRRRWREVEECAGTKELLCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVE :::::::::::::::::::::::::::::: XP_016 MMCLKKQDLYNKFKGRVRTVSPSSKSPWVE 10 20 30 120 130 140 150 160 170 pF1KF0 SEYLDYLFEVEPAPPVLVLTQTEEILSANATYQLPPCMPPLDLKYEVAFWKEGAGNKTLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEYLDYLFEVEPAPPVLVLTQTEEILSANATYQLPPCMPPLDLKYEVAFWKEGAGNKTLF 40 50 60 70 80 90 180 190 200 210 220 230 pF1KF0 PVTPHGQPVQITLQPAASEHHCLSARTIYTFSVPKYSKFSKPTCFLLEVPEANWAFLVLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PVTPHGQPVQITLQPAASEHHCLSARTIYTFSVPKYSKFSKPTCFLLEVPEANWAFLVLP 100 110 120 130 140 150 240 250 260 270 280 290 pF1KF0 SLLILLLVIAAGGVIWKTLMGNPWFQRAKMPRALDFSGHTHPVATFQPSRPESVNDLFLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLLILLLVIAAGGVIWKTLMGNPWFQRAKMPRALDFSGHTHPVATFQPSRPESVNDLFLC 160 170 180 190 200 210 300 310 320 330 340 350 pF1KF0 PQKELTRGVRPTPRVRAPATQQTRWKKDLAEDEEEEDEEDTEDGVSFQPYIEPPSFLGQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PQKELTRGVRPTPRVRAPATQQTRWKKDLAEDEEEEDEEDTEDGVSFQPYIEPPSFLGQE 220 230 240 250 260 270 360 370 380 390 400 410 pF1KF0 HQAPGHSEAGGVDSGRPRAPLVPSEGSSAWDSSDRSWASTVDSSWDRAGSSGYLAEKGPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HQAPGHSEAGGVDSGRPRAPLVPSEGSSAWDSSDRSWASTVDSSWDRAGSSGYLAEKGPG 280 290 300 310 320 330 420 430 440 450 460 470 pF1KF0 QGPGGDGHQESLPPPEFSKDSGFLEELPEDNLSSWATWGTLPPEPNLVPGGPPVSLQTLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QGPGGDGHQESLPPPEFSKDSGFLEELPEDNLSSWATWGTLPPEPNLVPGGPPVSLQTLT 340 350 360 370 380 390 480 490 500 510 520 pF1KF0 FCWESSPEEEEEARESEIEDSDAGSWGAESTQRTEDRGRTLGHYMAR ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FCWESSPEEEEEARESEIEDSDAGSWGAESTQRTEDRGRTLGHYMAR 400 410 420 430 >>NP_775087 (OMIM: 607404) interferon lambda receptor 1 (491 aa) initn: 1904 init1: 1856 opt: 1872 Z-score: 1524.9 bits: 291.7 E(91774): 3.6e-78 Smith-Waterman score: 3352; 94.4% identity (94.4% similar) in 520 aa overlap (1-520:1-491) 10 20 30 40 50 60 pF1KF0 MAGPERWGPLLLCLLQAAPGRPRLAPPQNVTLLSQNFSVYLTWLPGLGNPQDVTYFVAYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 MAGPERWGPLLLCLLQAAPGRPRLAPPQNVTLLSQNFSVYLTWLPGLGNPQDVTYFVAYQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KF0 SSPTRRRWREVEECAGTKELLCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVESEYLDYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 SSPTRRRWREVEECAGTKELLCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVESEYLDYL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KF0 FEVEPAPPVLVLTQTEEILSANATYQLPPCMPPLDLKYEVAFWKEGAGNKTLFPVTPHGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 FEVEPAPPVLVLTQTEEILSANATYQLPPCMPPLDLKYEVAFWKEGAGNKTLFPVTPHGQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KF0 PVQITLQPAASEHHCLSARTIYTFSVPKYSKFSKPTCFLLEVPEANWAFLVLPSLLILLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 PVQITLQPAASEHHCLSARTIYTFSVPKYSKFSKPTCFLLEVPEANWAFLVLPSLLILLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KF0 VIAAGGVIWKTLMGNPWFQRAKMPRALDFSGHTHPVATFQPSRPESVNDLFLCPQKELTR ::::::::::::::::::::::::::: :::: NP_775 VIAAGGVIWKTLMGNPWFQRAKMPRAL-----------------------------ELTR 250 260 270 310 320 330 340 350 360 pF1KF0 GVRPTPRVRAPATQQTRWKKDLAEDEEEEDEEDTEDGVSFQPYIEPPSFLGQEHQAPGHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 GVRPTPRVRAPATQQTRWKKDLAEDEEEEDEEDTEDGVSFQPYIEPPSFLGQEHQAPGHS 280 290 300 310 320 330 370 380 390 400 410 420 pF1KF0 EAGGVDSGRPRAPLVPSEGSSAWDSSDRSWASTVDSSWDRAGSSGYLAEKGPGQGPGGDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 EAGGVDSGRPRAPLVPSEGSSAWDSSDRSWASTVDSSWDRAGSSGYLAEKGPGQGPGGDG 340 350 360 370 380 390 430 440 450 460 470 480 pF1KF0 HQESLPPPEFSKDSGFLEELPEDNLSSWATWGTLPPEPNLVPGGPPVSLQTLTFCWESSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 HQESLPPPEFSKDSGFLEELPEDNLSSWATWGTLPPEPNLVPGGPPVSLQTLTFCWESSP 400 410 420 430 440 450 490 500 510 520 pF1KF0 EEEEEARESEIEDSDAGSWGAESTQRTEDRGRTLGHYMAR :::::::::::::::::::::::::::::::::::::::: NP_775 EEEEEARESEIEDSDAGSWGAESTQRTEDRGRTLGHYMAR 460 470 480 490 >>XP_024309436 (OMIM: 607404) interferon lambda receptor (319 aa) initn: 1791 init1: 1791 opt: 1791 Z-score: 1462.0 bits: 279.4 E(91774): 1.2e-74 Smith-Waterman score: 1791; 99.2% identity (99.6% similar) in 256 aa overlap (265-520:64-319) 240 250 260 270 280 290 pF1KF0 LLILLLVIAAGGVIWKTLMGNPWFQRAKMPRALDFSGHTHPVATFQPSRPESVNDLFLCP :. ::::::::::::::::::::::::::: XP_024 ANTTASVPEPSTRSVSRNTASSLSPPASCWRSQDFSGHTHPVATFQPSRPESVNDLFLCP 40 50 60 70 80 90 300 310 320 330 340 350 pF1KF0 QKELTRGVRPTPRVRAPATQQTRWKKDLAEDEEEEDEEDTEDGVSFQPYIEPPSFLGQEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 QKELTRGVRPTPRVRAPATQQTRWKKDLAEDEEEEDEEDTEDGVSFQPYIEPPSFLGQEH 100 110 120 130 140 150 360 370 380 390 400 410 pF1KF0 QAPGHSEAGGVDSGRPRAPLVPSEGSSAWDSSDRSWASTVDSSWDRAGSSGYLAEKGPGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 QAPGHSEAGGVDSGRPRAPLVPSEGSSAWDSSDRSWASTVDSSWDRAGSSGYLAEKGPGQ 160 170 180 190 200 210 420 430 440 450 460 470 pF1KF0 GPGGDGHQESLPPPEFSKDSGFLEELPEDNLSSWATWGTLPPEPNLVPGGPPVSLQTLTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_024 GPGGDGHQESLPPPEFSKDSGFLEELPEDNLSSWATWGTLPPEPNLVPGGPPVSLQTLTF 220 230 240 250 260 270 480 490 500 510 520 pF1KF0 CWESSPEEEEEARESEIEDSDAGSWGAESTQRTEDRGRTLGHYMAR :::::::::::::::::::::::::::::::::::::::::::::: XP_024 CWESSPEEEEEARESEIEDSDAGSWGAESTQRTEDRGRTLGHYMAR 280 290 300 310 >>NP_775088 (OMIM: 607404) interferon lambda receptor 1 (244 aa) initn: 1549 init1: 1549 opt: 1555 Z-score: 1272.7 bits: 244.0 E(91774): 4e-64 Smith-Waterman score: 1555; 98.7% identity (98.7% similar) in 227 aa overlap (1-227:1-227) 10 20 30 40 50 60 pF1KF0 MAGPERWGPLLLCLLQAAPGRPRLAPPQNVTLLSQNFSVYLTWLPGLGNPQDVTYFVAYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 MAGPERWGPLLLCLLQAAPGRPRLAPPQNVTLLSQNFSVYLTWLPGLGNPQDVTYFVAYQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KF0 SSPTRRRWREVEECAGTKELLCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVESEYLDYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 SSPTRRRWREVEECAGTKELLCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVESEYLDYL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KF0 FEVEPAPPVLVLTQTEEILSANATYQLPPCMPPLDLKYEVAFWKEGAGNKTLFPVTPHGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 FEVEPAPPVLVLTQTEEILSANATYQLPPCMPPLDLKYEVAFWKEGAGNKTLFPVTPHGQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KF0 PVQITLQPAASEHHCLSARTIYTFSVPKYSKFSKPTCFLLEVPEANWAFLVLPSLLILLL ::::::::::::::::::::::::::::::::::::::::::: : NP_775 PVQITLQPAASEHHCLSARTIYTFSVPKYSKFSKPTCFLLEVPGLFWTHTPCGNLSAQQT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KF0 VIAAGGVIWKTLMGNPWFQRAKMPRALDFSGHTHPVATFQPSRPESVNDLFLCPQKELTR NP_775 RVRE >>NP_851826 (OMIM: 606648) interleukin-22 receptor subun (231 aa) initn: 217 init1: 135 opt: 227 Z-score: 198.6 bits: 45.2 E(91774): 0.00027 Smith-Waterman score: 231; 30.8% identity (54.0% similar) in 211 aa overlap (27-223:31-231) 10 20 30 40 50 pF1KF0 MAGPERWGPLLLCLLQAAPGRPRLAPPQNVTLLSQNFSVYLTWLPG---LGNPQDV :: : . :.:: : : :: :: . NP_851 MMPKHCFLGFLISFFLTGVAGTQSTHESLKPQRVQFQSRNFHNILQWQPGRALTGNSS-- 10 20 30 40 50 60 70 80 90 100 110 pF1KF0 TYFVAYQSSPTRRRWREVEECAGTKELLCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVE .::: :. .:.:.. :.: ::.:: :.. . .:. . . ::::..: .: : : NP_851 VYFVQYKIYG-QRQWKNKEDCWGTQELSCDLTS-ETSDIQEPYYGRVRAASAGSYSEWSM 60 70 80 90 100 110 120 130 140 150 160 pF1KF0 SEYLDYLFEVEPAPPVLVLTQTEE----ILSANAT---YQLPPCMPPLD---LKYEVAFW . . .:.. :::. .::.. :: : :: . : : :.: : NP_851 TPRFTPWWETKIDPPVMNITQVNGSLLVILHAPNLPYRYQKEKNVSIEDYYELLYRV-FI 120 130 140 150 160 170 170 180 190 200 210 220 pF1KF0 KEGAGNKTLFPVTPHGQPVQI-TLQPAASEHHCLSARTIYTFSVPKYSKFSKPTCFLLEV ... .: . :.: .: : .: .:. :. :: . . :. :. : .:. NP_851 INNSLEKEQKVYEGAHRAVEIEALTPHSS--YCVVAE-IYQPMLDRRSQRSEERC--VEI 180 190 200 210 220 230 230 240 250 260 270 280 pF1KF0 PEANWAFLVLPSLLILLLVIAAGGVIWKTLMGNPWFQRAKMPRALDFSGHTHPVATFQPS : NP_851 P >>XP_016866443 (OMIM: 605620) interleukin-20 receptor su (554 aa) initn: 104 init1: 67 opt: 206 Z-score: 176.3 bits: 42.3 E(91774): 0.0048 Smith-Waterman score: 220; 26.4% identity (54.2% similar) in 227 aa overlap (9-217:16-237) 10 20 30 40 pF1KF0 MAGPERWGPLLLCLLQAAPGR--P----RLAPPQNVTLLSQNFSVYLTWLPGL :::: :: : :: : : : :.:.:: :.. : : : XP_016 MRAPGRPALRPLPLPPLLLLLLAAPWGRAVPCVSGGLPKPANITFLSINMKNVLQWTPPE 10 20 30 40 50 60 50 60 70 80 90 100 pF1KF0 G-NPQDVTYFVAYQSSPTRRRWREVEECAGTKELLCSMMCLKKQDLYNKFKGRVRTVSPS : . ::: : : ...: . :: . .. :.. . .: ... ..:... . XP_016 GLQGVKVTYTVQYFIRYGQKKWLNKSECRNINRTYCDLSA-ETSDYEHQYYAKVKAIWGT 70 80 90 100 110 110 120 130 140 150 pF1KF0 SKSPWVESEYLDYLFEVEPAPPVLVLTQTEE----ILSANATYQ-----LPPCMPPL--D . : :.:: . ..:.. .:: ..:: :. .:.: .. :: : . . XP_016 KCSKWAESGRFYPFLETQIGPPEVALTTDEKSISVVLTAPEKWKRNPEDLPVSMQQIYSN 120 130 140 150 160 170 160 170 180 190 200 210 pF1KF0 LKYEVAFWKEGAGNKTLFPVTPHGQPVQITLQPAASEHHCLSARTIYTFSVPKYSKFSKP :::.:. . . :.: . . : :.: . .:. ... .. . :. .. :. XP_016 LKYNVSVLNTKS-NRTWSQCVTNHTLVLTWLEP--NTLYCVHVES-FVPGPPRRAQPSEK 180 190 200 210 220 230 220 230 240 250 260 270 pF1KF0 TCFLLEVPEANWAFLVLPSLLILLLVIAAGGVIWKTLMGNPWFQRAKMPRALDFSGHTHP : XP_016 QCARTLKDQSSEFKAKIIFWYVLPVSITVFLFSVMGYSIYRYIHVGKEKHPANLILIYGN 240 250 260 270 280 290 >>NP_851827 (OMIM: 606648) interleukin-22 receptor subun (130 aa) initn: 227 init1: 135 opt: 194 Z-score: 175.4 bits: 40.1 E(91774): 0.0053 Smith-Waterman score: 194; 38.6% identity (62.5% similar) in 88 aa overlap (27-111:31-114) 10 20 30 40 50 pF1KF0 MAGPERWGPLLLCLLQAAPGRPRLAPPQNVTLLSQNFSVYLTWLPG---LGNPQDV :: : . :.:: : : :: :: . NP_851 MMPKHCFLGFLISFFLTGVAGTQSTHESLKPQRVQFQSRNFHNILQWQPGRALTGNSS-- 10 20 30 40 50 60 70 80 90 100 110 pF1KF0 TYFVAYQSSPTRRRWREVEECAGTKELLCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVE .::: :. .:.:.. :.: ::.:: :.. . .:. . . ::::..: .: : : NP_851 VYFVQYKIYG-QRQWKNKEDCWGTQELSCDLTS-ETSDIQEPYYGRVRAASAGSYSEWSM 60 70 80 90 100 110 120 130 140 150 160 170 pF1KF0 SEYLDYLFEVEPAPPVLVLTQTEEILSANATYQLPPCMPPLDLKYEVAFWKEGAGNKTLF NP_851 TPRFTPWWERAKGL 120 130 >>NP_000619 (OMIM: 123889,610424,612567) interleukin-10 (325 aa) initn: 93 init1: 64 opt: 199 Z-score: 173.9 bits: 41.1 E(91774): 0.0065 Smith-Waterman score: 199; 25.2% identity (53.0% similar) in 298 aa overlap (13-291:12-292) 10 20 30 40 50 60 pF1KF0 MAGPERWGPLLLCLLQAAPGRPRLAPPQNVTLLSQNFSVYLTWLPGLGNPQDVTYFVAYQ ::: .: : . ::.:: . : ::. : : ..:. . : NP_000 MAWSLGSWLGGCLLVSALG--MVPPPENVRMNSVNFKNILQWESPAFAKGNLTFTAQYL 10 20 30 40 50 70 80 90 100 110 pF1KF0 SSPTRRRWREVEECAGTKELLCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVESEY--LD : : ... .: .: :.. :.: :. :::. . .: ::. . .: NP_000 S---YRIFQD--KCMNTTLTECDFSSLSK---YGDHTLRVRAEFADEHSDWVNITFCPVD 60 70 80 90 100 120 130 140 150 160 170 pF1KF0 YLFEVEPAPPVLVLTQT-------EEILSANATYQLPPCMPPLDLKYEVAFWKEGAGNKT . :. : ::... .: . :. . . . :.: .::.:. .: NP_000 DTIIGPPGMQVEVLADSLHMRFLAPKIENEYETWTMKNVYN--SWTYNVQYWKNGTDEK- 110 120 130 140 150 160 180 190 200 210 220 pF1KF0 LFPVTPHGQ-PVQITLQPAASEHHCLSARTIYTFSVPKYSKFSKPTCFLLEVPEA--NW- : .::. . : .:.: .. .:...: . . : ...:.:.: :. .: NP_000 -FQITPQYDFEVLRNLEPWTT--YCVQVRG-FLPDRNKAGEWSEPVCEQTTHDETVPSWM 170 180 190 200 210 220 230 240 250 260 270 280 pF1KF0 -AFLVLPSL-LILLLVIAAGGVIWKTLMGNPW-FQ-RAKMPRAL-DFSGHTHPVATFQPS : ... :. .. : ... ...: . . . :. : ..:. : .: :: : . . : NP_000 VAVILMASVFMVCLALLGCFALLWCVYKKTKYAFSPRNSLPQHLKEFLGHPHHNTLLFFS 230 240 250 260 270 280 290 300 310 320 330 340 pF1KF0 RPES-VNDLFLCPQKELTRGVRPTPRVRAPATQQTRWKKDLAEDEEEEDEEDTEDGVSFQ : : ::.: NP_000 FPLSDENDVFDKLSVIAEDSESGKQNPGDSCSLGTPPGQGPQS 290 300 310 320 520 residues in 1 query sequences 64092750 residues in 91774 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Jul 18 21:05:59 2019 done: Thu Jul 18 21:06:00 2019 Total Scan time: 5.790 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]