FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KF0229, 608 aa 1>>>pF1KF0229 608 - 608 aa - 608 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5016+/-0.000787; mu= 18.5709+/- 0.048 mean_var=75.4953+/-15.017, 0's: 0 Z-trim(109.3): 12 B-trim: 0 in 0/51 Lambda= 0.147610 statistics sampled from 10801 (10805) to 10801 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.707), E-opt: 0.2 (0.332), width: 16 Scan time: 3.760 The best scores are: opt bits E(32554) CCDS33773.1 DENND6A gene_id:201627|Hs108|chr3 ( 608) 4125 887.9 0 CCDS46732.1 DENND6B gene_id:414918|Hs108|chr22 ( 585) 2434 527.8 1.5e-149 >>CCDS33773.1 DENND6A gene_id:201627|Hs108|chr3 (608 aa) initn: 4125 init1: 4125 opt: 4125 Z-score: 4744.1 bits: 887.9 E(32554): 0 Smith-Waterman score: 4125; 99.8% identity (100.0% similar) in 608 aa overlap (1-608:1-608) 10 20 30 40 50 60 pF1KF0 MALRGPAGLGPGSRRPLDEAVAGAEGREAPALVAAGGAPEDDEEDDGRGRGLLRWDSFSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 MALRGPAGLGPGSRRPLDEAVAGAEGREAPALVAAGGAPEDDEEDDGRGRGLLRWDSFSA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KF0 WLHCVCVVGFDLELGQAVEVIYPQHSKLTDREKTNICYLSFPDSNSGCLGDTQFCFRFRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 WLHCVCVVGFDLELGQAVEVIYPQHSKLTDREKTNICYLSFPDSNSGCLGDTQFCFRFRQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KF0 SSGRRVSLHCLLDQFDKDLPVYLKKDPAYFYGYVYFRQVRDKTLKRGYFQKSLVLISKLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 SSGRRVSLHCLLDQFDKDLPVYLKKDPAYFYGYVYFRQVRDKTLKRGYFQKSLVLISKLP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KF0 YIHFFHTVLKQIAPEYFEKNEPYLEAACNDVDRWPAPVPGKTLHLPIMAVVMKVRIPTCH ::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::: CCDS33 YIHFFHTVLKQIAPEYFEKNEPYLEAACNDVDRWPAPVPGKTLHLPIMGVVMKVRIPTCH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KF0 DKPGTTQIVQLTQQVDTNISVILPTVHEVDIFRCFCPVFLHSQMLWELVLLGEPLVVMAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 DKPGTTQIVQLTQQVDTNISVILPTVHEVDIFRCFCPVFLHSQMLWELVLLGEPLVVMAP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KF0 SPSESSETVLALVNCISPLKYFSDFRPYFTIHDSEFKEYTTRTQAPPSVILGVTNPFFAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 SPSESSETVLALVNCISPLKYFSDFRPYFTIHDSEFKEYTTRTQAPPSVILGVTNPFFAK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KF0 TLQHWPHIIRIGDLKPTGEIPKQVKVKKLKNLKTLDSKPGVYTSYKPYLNRDEEIIKQLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 TLQHWPHIIRIGDLKPTGEIPKQVKVKKLKNLKTLDSKPGVYTSYKPYLNRDEEIIKQLQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KF0 KGVQQKRPSEAQSVILRRYFLELTQSFIIPLERYVASLMPLQKSISPWKSPPQLRQFLPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 KGVQQKRPSEAQSVILRRYFLELTQSFIIPLERYVASLMPLQKSISPWKSPPQLRQFLPE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KF0 EFMKTLEKTGPQLTSRIKGDWIGLYRHFLKSPNFDGWFKTRRKEMTQKLEALHLEALCEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 EFMKTLEKTGPQLTSRIKGDWIGLYRHFLKSPNFDGWFKTRRKEMTQKLEALHLEALCEE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KF0 DLLLWIQKHTEVETVDLVLKLKNKLLQADREHLPVKPDTMEKLRTHIDAIILALPEDLQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 DLLLWIQKHTEVETVDLVLKLKNKLLQADREHLPVKPDTMEKLRTHIDAIILALPEDLQG 550 560 570 580 590 600 pF1KF0 ILLKTGMT :::::::: CCDS33 ILLKTGMT >>CCDS46732.1 DENND6B gene_id:414918|Hs108|chr22 (585 aa) initn: 2469 init1: 2434 opt: 2434 Z-score: 2798.2 bits: 527.8 E(32554): 1.5e-149 Smith-Waterman score: 2434; 60.6% identity (87.2% similar) in 548 aa overlap (55-602:35-582) 30 40 50 60 70 80 pF1KF0 EGREAPALVAAGGAPEDDEEDDGRGRGLLRWDSFSAWLHCVCVVGFDLELGQAVEVIYPQ : :::::.::::: ::::::::.:..::. CCDS46 LGTGPRRARGCLGAAGPTSSGRAARTPAAPWARFSAWLECVCVVTFDLELGQALELVYPN 10 20 30 40 50 60 90 100 110 120 130 140 pF1KF0 HSKLTDREKTNICYLSFPDSNSGCLGDTQFCFRFRQSSGRRVSLHCLLDQFDKDLPVYLK .:::.::..:::::::::.::::::::: ::.:: .:.: : .... :: :. CCDS46 DFRLTDKEKSSICYLSFPDSHSGCLGDTQFSFRMRQCGGQRSPWHADDRHYNSRAPVALQ 70 80 90 100 110 120 150 160 170 180 190 200 pF1KF0 KDPAYFYGYVYFRQVRDKTLKRGYFQKSLVLISKLPYIHFFHTVLKQIAPEYFEKNEPYL ..::...::::::::.:...:::::::::::.:.::....:...:. ::::::.: : : CCDS46 REPAHYFGYVYFRQVKDSSVKRGYFQKSLVLVSRLPFVRLFQALLSLIAPEYFDKLAPCL 130 140 150 160 170 180 210 220 230 240 250 260 pF1KF0 EAACNDVDRWPAPVPGKTLHLPIMAVVMKVRIPTCHDKPGTTQIVQLTQQVDTNISVILP ::.:...:.::::.::.::.::.:.::..::::. :: .. :. :. :.: CCDS46 EAVCSEIDQWPAPAPGQTLNLPVMGVVVQVRIPSRVDKSESSPPKQFDQENLLPAPVVLA 190 200 210 220 230 240 270 280 290 300 310 320 pF1KF0 TVHEVDIFRCFCPVFLHSQMLWELVLLGEPLVVMAPSPSESSETVLALVNCISPLKYFSD .:::.:.:::: ::. : : ::::.::::::.:.::::. ::: ::::..:..::.. : CCDS46 SVHELDLFRCFRPVLTHMQTLWELMLLGEPLLVLAPSPDVSSEMVLALTSCLQPLRFCCD 250 260 270 280 290 300 330 340 350 360 370 380 pF1KF0 FRPYFTIHDSEFKEYTTRTQAPPSVILGVTNPFFAKTLQHWPHIIRIGDLKPTGEIPKQV ::::::::::::::.::::::::.:.:::::::: :::::::::.:.:. : .:..:::: CCDS46 FRPYFTIHDSEFKEFTTRTQAPPNVVLGVTNPFFIKTLQHWPHILRVGEPKMSGDLPKQV 310 320 330 340 350 360 390 400 410 420 430 440 pF1KF0 KVKKLKNLKTLDSKPGVYTSYKPYLNRDEEIIKQLQKGVQQKRPSEAQSVILRRYFLELT :.:: . :::::.:::.::.: .:.::. ..:.: ::::.::::..::..:::..:::: CCDS46 KLKKPSRLKTLDTKPGLYTAYTAHLHRDKALLKRLLKGVQKKRPSDVQSALLRRHLLELT 370 380 390 400 410 420 450 460 470 480 490 500 pF1KF0 QSFIIPLERYVASLMPLQKSISPWKSPPQLRQFLPEEFMKTLEKTGPQLTSRIKGDWIGL ::::::::.:.::::::::::.:::.:::.. : ..:...::..::::: .::::.:: CCDS46 QSFIIPLEHYMASLMPLQKSITPWKTPPQIQPFSQDDFLRSLEHAGPQLTCILKGDWLGL 430 440 450 460 470 480 510 520 530 540 550 560 pF1KF0 YRHFLKSPNFDGWFKTRRKEMTQKLEALHLEALCEEDLLLWIQKHTEVETVDLVLKLKNK ::.:.:::.::::.. :.:::. :::::::::.:: .. :.. ..:::.:::::::..: CCDS46 YRRFFKSPHFDGWYRQRHKEMALKLEALHLEAICEANIETWMKDKSEVEVVDLVLKLREK 490 500 510 520 530 540 570 580 590 600 pF1KF0 LLQADREHLPVKPDTMEKLRTHIDAIILALPEDLQGILLKTGMT :..:. ..:::: :... . .:...: .::.:::..: CCDS46 LVRAQGHQLPVKEATLQRAQLYIETVIGSLPKDLQAVLCPP 550 560 570 580 608 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 19:26:44 2016 done: Thu Nov 3 19:26:44 2016 Total Scan time: 3.760 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]