Result of FASTA (omim) for
pF1KF0267
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KF0267, 1101 aa
1>>>pF1KF0267 1101 - 1101 aa - 1101 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.3871+/-0.000399; mu= -6.1842+/- 0.025
mean_var=333.9858+/-66.254, 0's: 0 Z-trim(122.4): 373 B-trim: 0 in 0/59
Lambda= 0.070179
statistics sampled from 39998 (40386) to 39998 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.771), E-opt: 0.2 (0.474), width: 16
Scan time: 18.160
The best scores are: opt bits E(85289)
NP_001020769 (OMIM: 614264) rho GTPase-activating (1101) 7429 766.8 0
XP_011507693 (OMIM: 614264) PREDICTED: rho GTPase- ( 953) 6447 667.4 1.1e-190
NP_001274529 (OMIM: 614264) rho GTPase-activating ( 953) 6447 667.4 1.1e-190
XP_005245130 (OMIM: 614264) PREDICTED: rho GTPase- ( 953) 6447 667.4 1.1e-190
NP_001274531 (OMIM: 614264) rho GTPase-activating ( 924) 6245 646.9 1.6e-184
NP_859071 (OMIM: 614264) rho GTPase-activating pro ( 890) 4572 477.5 1.5e-133
XP_016856449 (OMIM: 614264) PREDICTED: rho GTPase- ( 967) 4256 445.5 6.9e-124
XP_005245127 (OMIM: 614264) PREDICTED: rho GTPase- (1044) 3684 387.7 2e-106
NP_001166101 (OMIM: 614902) rho GTPase-activating (1123) 1076 123.6 6.5e-27
XP_011524721 (OMIM: 614902) PREDICTED: rho GTPase- (1123) 1076 123.6 6.5e-27
XP_011524719 (OMIM: 614902) PREDICTED: rho GTPase- (1152) 1076 123.6 6.6e-27
XP_005258545 (OMIM: 614902) PREDICTED: rho GTPase- (1287) 1076 123.7 7.2e-27
NP_443180 (OMIM: 614902) rho GTPase-activating pro (1126) 1031 119.1 1.5e-25
XP_011524723 (OMIM: 614902) PREDICTED: rho GTPase- ( 703) 1023 118.1 1.8e-25
XP_011524720 (OMIM: 614902) PREDICTED: rho GTPase- (1134) 1028 118.8 1.9e-25
XP_011524718 (OMIM: 614902) PREDICTED: rho GTPase- (1161) 1028 118.8 1.9e-25
XP_011524722 (OMIM: 614902) PREDICTED: rho GTPase- (1162) 1028 118.8 1.9e-25
XP_006723062 (OMIM: 614902) PREDICTED: rho GTPase- (1298) 1028 118.8 2.1e-25
NP_055530 (OMIM: 608541) rho GTPase-activating pro (1738) 1027 118.8 2.8e-25
XP_011541377 (OMIM: 608541) PREDICTED: rho GTPase- (1762) 1027 118.8 2.9e-25
XP_016874085 (OMIM: 608541) PREDICTED: rho GTPase- (2008) 1027 118.8 3.2e-25
XP_016874084 (OMIM: 608541) PREDICTED: rho GTPase- (2061) 1027 118.8 3.3e-25
XP_011541374 (OMIM: 608541) PREDICTED: rho GTPase- (2061) 1027 118.8 3.3e-25
XP_011541375 (OMIM: 608541) PREDICTED: rho GTPase- (2074) 1027 118.8 3.3e-25
NP_001136157 (OMIM: 608541) rho GTPase-activating (2087) 1027 118.8 3.3e-25
XP_005271793 (OMIM: 608541) PREDICTED: rho GTPase- (2101) 1027 118.8 3.3e-25
XP_016874086 (OMIM: 608541) PREDICTED: rho GTPase- ( 660) 1005 116.3 6.2e-25
XP_016881727 (OMIM: 614902) PREDICTED: rho GTPase- ( 711) 998 115.6 1.1e-24
XP_006713777 (OMIM: 100300,610911) PREDICTED: rho (1424) 1000 116.0 1.6e-24
NP_065805 (OMIM: 100300,610911) rho GTPase-activat (1444) 1000 116.0 1.6e-24
XP_016872443 (OMIM: 610577) PREDICTED: rho GTPase- ( 742) 435 58.6 1.6e-07
NP_001257627 (OMIM: 610577) rho GTPase-activating ( 769) 435 58.6 1.6e-07
XP_011518063 (OMIM: 610577) PREDICTED: rho GTPase- ( 772) 435 58.6 1.6e-07
NP_001257628 (OMIM: 610577) rho GTPase-activating ( 794) 435 58.6 1.7e-07
XP_005252701 (OMIM: 610577) PREDICTED: rho GTPase- ( 794) 435 58.6 1.7e-07
NP_001257626 (OMIM: 610577) rho GTPase-activating ( 799) 435 58.6 1.7e-07
NP_001257625 (OMIM: 610577) rho GTPase-activating ( 816) 435 58.6 1.7e-07
NP_001257624 (OMIM: 610577) rho GTPase-activating ( 841) 435 58.6 1.8e-07
NP_060757 (OMIM: 610577) rho GTPase-activating pro ( 846) 435 58.6 1.8e-07
NP_954976 (OMIM: 610591) rho GTPase-activating pro ( 548) 426 57.6 2.4e-07
XP_011522776 (OMIM: 610591) PREDICTED: rho GTPase- ( 581) 426 57.6 2.5e-07
XP_005257185 (OMIM: 610591) PREDICTED: rho GTPase- ( 667) 426 57.7 2.8e-07
XP_016879801 (OMIM: 610591) PREDICTED: rho GTPase- ( 689) 426 57.7 2.8e-07
XP_011522774 (OMIM: 610591) PREDICTED: rho GTPase- ( 722) 426 57.7 2.9e-07
XP_011509785 (OMIM: 610578) PREDICTED: rho GTPase- ( 397) 418 56.7 3.2e-07
XP_011522773 (OMIM: 610591) PREDICTED: rho GTPase- ( 865) 426 57.7 3.4e-07
XP_006721810 (OMIM: 610591) PREDICTED: rho GTPase- ( 867) 426 57.7 3.4e-07
XP_016859989 (OMIM: 610578) PREDICTED: rho GTPase- ( 432) 418 56.7 3.4e-07
XP_006721808 (OMIM: 610591) PREDICTED: rho GTPase- ( 889) 426 57.7 3.5e-07
NP_001269219 (OMIM: 610591) rho GTPase-activating ( 889) 426 57.7 3.5e-07
>>NP_001020769 (OMIM: 614264) rho GTPase-activating prot (1101 aa)
initn: 7429 init1: 7429 opt: 7429 Z-score: 4080.6 bits: 766.8 E(85289): 0
Smith-Waterman score: 7429; 99.8% identity (99.9% similar) in 1101 aa overlap (1-1101:1-1101)
10 20 30 40 50 60
pF1KF0 MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KF0 QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KF0 KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KF0 PEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KF0 ETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KF0 ENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KF0 PLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEAS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KF0 PASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KF0 FSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSVDSAGPRPEV
::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::
NP_001 FSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KF0 EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGED
610 620 630 640 650 660
670 680 690 700 710 720
pF1KF0 KQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KF0 KGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KF0 EKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKERES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKERES
790 800 810 820 830 840
850 860 870 880 890 900
pF1KF0 GDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEMEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEMEP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KF0 EGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVA
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KF0 PANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRTQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRTQT
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KF0 CTEGGDYCLIPRTPPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDPLL
::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CTEGGDYCLIPRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDPLL
1030 1040 1050 1060 1070 1080
1090 1100
pF1KF0 SSQRRSYAFETQANPGKGEGL
:::::::::::::::::::::
NP_001 SSQRRSYAFETQANPGKGEGL
1090 1100
>>XP_011507693 (OMIM: 614264) PREDICTED: rho GTPase-acti (953 aa)
initn: 6447 init1: 6447 opt: 6447 Z-score: 3544.2 bits: 667.4 E(85289): 1.1e-190
Smith-Waterman score: 6447; 99.8% identity (99.9% similar) in 953 aa overlap (149-1101:1-953)
120 130 140 150 160 170
pF1KF0 GVQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLL
::::::::::::::::::::::::::::::
XP_011 MRHLVHMASFSAQTNMHARNLAIVWAPNLL
10 20 30
180 190 200 210 220 230
pF1KF0 RSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRAS
40 50 60 70 80 90
240 250 260 270 280 290
pF1KF0 GSPEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSPEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRS
100 110 120 130 140 150
300 310 320 330 340 350
pF1KF0 GHETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GHETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPE
160 170 180 190 200 210
360 370 380 390 400 410
pF1KF0 SLENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNV
220 230 240 250 260 270
420 430 440 450 460 470
pF1KF0 NLPLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLPLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLE
280 290 300 310 320 330
480 490 500 510 520 530
pF1KF0 ASPASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASPASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAG
340 350 360 370 380 390
540 550 560 570 580 590
pF1KF0 AAFSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSVDSAGPRP
::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::
XP_011 AAFSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRP
400 410 420 430 440 450
600 610 620 630 640 650
pF1KF0 EVEEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVEEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVG
460 470 480 490 500 510
660 670 680 690 700 710
pF1KF0 EDKQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDKQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEE
520 530 540 550 560 570
720 730 740 750 760 770
pF1KF0 KSKGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSKGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQV
580 590 600 610 620 630
780 790 800 810 820 830
pF1KF0 AEEKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEEKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKER
640 650 660 670 680 690
840 850 860 870 880 890
pF1KF0 ESGDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESGDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEM
700 710 720 730 740 750
900 910 920 930 940 950
pF1KF0 EPEGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPEGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIH
760 770 780 790 800 810
960 970 980 990 1000 1010
pF1KF0 VAPANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VAPANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRT
820 830 840 850 860 870
1020 1030 1040 1050 1060 1070
pF1KF0 QTCTEGGDYCLIPRTPPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDP
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTCTEGGDYCLIPRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDP
880 890 900 910 920 930
1080 1090 1100
pF1KF0 LLSSQRRSYAFETQANPGKGEGL
:::::::::::::::::::::::
XP_011 LLSSQRRSYAFETQANPGKGEGL
940 950
>>NP_001274529 (OMIM: 614264) rho GTPase-activating prot (953 aa)
initn: 6447 init1: 6447 opt: 6447 Z-score: 3544.2 bits: 667.4 E(85289): 1.1e-190
Smith-Waterman score: 6447; 99.8% identity (99.9% similar) in 953 aa overlap (149-1101:1-953)
120 130 140 150 160 170
pF1KF0 GVQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLL
::::::::::::::::::::::::::::::
NP_001 MRHLVHMASFSAQTNMHARNLAIVWAPNLL
10 20 30
180 190 200 210 220 230
pF1KF0 RSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRAS
40 50 60 70 80 90
240 250 260 270 280 290
pF1KF0 GSPEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSPEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRS
100 110 120 130 140 150
300 310 320 330 340 350
pF1KF0 GHETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GHETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPE
160 170 180 190 200 210
360 370 380 390 400 410
pF1KF0 SLENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNV
220 230 240 250 260 270
420 430 440 450 460 470
pF1KF0 NLPLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLPLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLE
280 290 300 310 320 330
480 490 500 510 520 530
pF1KF0 ASPASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASPASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAG
340 350 360 370 380 390
540 550 560 570 580 590
pF1KF0 AAFSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSVDSAGPRP
::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::
NP_001 AAFSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRP
400 410 420 430 440 450
600 610 620 630 640 650
pF1KF0 EVEEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVEEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVG
460 470 480 490 500 510
660 670 680 690 700 710
pF1KF0 EDKQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDKQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEE
520 530 540 550 560 570
720 730 740 750 760 770
pF1KF0 KSKGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSKGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQV
580 590 600 610 620 630
780 790 800 810 820 830
pF1KF0 AEEKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEEKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKER
640 650 660 670 680 690
840 850 860 870 880 890
pF1KF0 ESGDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESGDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEM
700 710 720 730 740 750
900 910 920 930 940 950
pF1KF0 EPEGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPEGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIH
760 770 780 790 800 810
960 970 980 990 1000 1010
pF1KF0 VAPANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAPANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRT
820 830 840 850 860 870
1020 1030 1040 1050 1060 1070
pF1KF0 QTCTEGGDYCLIPRTPPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDP
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
NP_001 QTCTEGGDYCLIPRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDP
880 890 900 910 920 930
1080 1090 1100
pF1KF0 LLSSQRRSYAFETQANPGKGEGL
:::::::::::::::::::::::
NP_001 LLSSQRRSYAFETQANPGKGEGL
940 950
>>XP_005245130 (OMIM: 614264) PREDICTED: rho GTPase-acti (953 aa)
initn: 6447 init1: 6447 opt: 6447 Z-score: 3544.2 bits: 667.4 E(85289): 1.1e-190
Smith-Waterman score: 6447; 99.8% identity (99.9% similar) in 953 aa overlap (149-1101:1-953)
120 130 140 150 160 170
pF1KF0 GVQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLL
::::::::::::::::::::::::::::::
XP_005 MRHLVHMASFSAQTNMHARNLAIVWAPNLL
10 20 30
180 190 200 210 220 230
pF1KF0 RSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRAS
40 50 60 70 80 90
240 250 260 270 280 290
pF1KF0 GSPEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSPEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRS
100 110 120 130 140 150
300 310 320 330 340 350
pF1KF0 GHETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GHETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPE
160 170 180 190 200 210
360 370 380 390 400 410
pF1KF0 SLENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNV
220 230 240 250 260 270
420 430 440 450 460 470
pF1KF0 NLPLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NLPLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLE
280 290 300 310 320 330
480 490 500 510 520 530
pF1KF0 ASPASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASPASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAG
340 350 360 370 380 390
540 550 560 570 580 590
pF1KF0 AAFSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSVDSAGPRP
::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::
XP_005 AAFSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRP
400 410 420 430 440 450
600 610 620 630 640 650
pF1KF0 EVEEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVEEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVG
460 470 480 490 500 510
660 670 680 690 700 710
pF1KF0 EDKQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDKQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEE
520 530 540 550 560 570
720 730 740 750 760 770
pF1KF0 KSKGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KSKGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQV
580 590 600 610 620 630
780 790 800 810 820 830
pF1KF0 AEEKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AEEKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKER
640 650 660 670 680 690
840 850 860 870 880 890
pF1KF0 ESGDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ESGDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEM
700 710 720 730 740 750
900 910 920 930 940 950
pF1KF0 EPEGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EPEGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIH
760 770 780 790 800 810
960 970 980 990 1000 1010
pF1KF0 VAPANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VAPANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRT
820 830 840 850 860 870
1020 1030 1040 1050 1060 1070
pF1KF0 QTCTEGGDYCLIPRTPPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDP
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
XP_005 QTCTEGGDYCLIPRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDP
880 890 900 910 920 930
1080 1090 1100
pF1KF0 LLSSQRRSYAFETQANPGKGEGL
:::::::::::::::::::::::
XP_005 LLSSQRRSYAFETQANPGKGEGL
940 950
>>NP_001274531 (OMIM: 614264) rho GTPase-activating prot (924 aa)
initn: 6245 init1: 6245 opt: 6245 Z-score: 3433.8 bits: 646.9 E(85289): 1.6e-184
Smith-Waterman score: 6245; 99.6% identity (99.9% similar) in 924 aa overlap (178-1101:1-924)
150 160 170 180 190 200
pF1KF0 LMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTAAFMEVRVQSIVVEFI
..::::::::::::::::::::::::::::
NP_001 MKSKDIEASGFNGTAAFMEVRVQSIVVEFI
10 20 30
210 220 230 240 250 260
pF1KF0 LTHVDQLFGGAALSGGEVESGWRSLPGTRASGSPEDLMPRPLPYHLPSILQAGDGPPQMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTHVDQLFGGAALSGGEVESGWRSLPGTRASGSPEDLMPRPLPYHLPSILQAGDGPPQMR
40 50 60 70 80 90
270 280 290 300 310 320
pF1KF0 PYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGHETKRKLPRGAEDREDKSNKGTLRPAKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGHETKRKLPRGAEDREDKSNKGTLRPAKS
100 110 120 130 140 150
330 340 350 360 370 380
pF1KF0 MDSLSAAAGASDEPEGLVGPSSPRPSPLLPESLENDSIEAAEGEQEPEAEALGGTNSEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDSLSAAAGASDEPEGLVGPSSPRPSPLLPESLENDSIEAAEGEQEPEAEALGGTNSEPG
160 170 180 190 200 210
390 400 410 420 430 440
pF1KF0 TPRAGRSAIRAGGSSRAERCAGVHISDPYNVNLPLHITSILSVPPNIISNVSLARLTRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPRAGRSAIRAGGSSRAERCAGVHISDPYNVNLPLHITSILSVPPNIISNVSLARLTRGL
220 230 240 250 260 270
450 460 470 480 490 500
pF1KF0 ECPALQHRPSPASGPGPGPGLGPGPPDEKLEASPASSPLADSGPDDLAPALEDSLSQEVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ECPALQHRPSPASGPGPGPGLGPGPPDEKLEASPASSPLADSGPDDLAPALEDSLSQEVQ
280 290 300 310 320 330
510 520 530 540 550 560
pF1KF0 DSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAAFSPGEDDPGMGYLEELLGVGPQVEEFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAAFSPGEDDPGMGYLEELLGVGPQVEEFS
340 350 360 370 380 390
570 580 590 600 610 620
pF1KF0 VEPPLDDLSLDEAQFVLAPSCCSVDSAGPRPEVEEENGEEVFLSAYDDLSPLLGPKPPIW
:::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::
NP_001 VEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEVEEENGEEVFLSAYDDLSPLLGPKPPIW
400 410 420 430 440 450
630 640 650 660 670 680
pF1KF0 KGSGSLEGEAAGCGRQALGQGGEEQACWEVGEDKQAEPGGRLDIREEAEGSPETKVEAGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGSGSLEGEAAGCGRQALGQGGEEQACWEVGEDKQAEPGGRLDIREEAEGSPETKVEAGK
460 470 480 490 500 510
690 700 710 720 730 740
pF1KF0 ASEDRGEAGGSQETKVRLREGSREETEAKEEKSKGQKKADSMEAKGVEEPGGDEYTDEKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASEDRGEAGGSQETKVRLREGSREETEAKEEKSKGQKKADSMEAKGVEEPGGDEYTDEKE
520 530 540 550 560 570
750 760 770 780 790 800
pF1KF0 KEIEREEDEQREEAQVEAGRDLEQGAQEDQVAEEKWEVVQKQEAEGVREDEDKGQREKGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KEIEREEDEQREEAQVEAGRDLEQGAQEDQVAEEKWEVVQKQEAEGVREDEDKGQREKGY
580 590 600 610 620 630
810 820 830 840 850 860
pF1KF0 HEARKDQGDGEDSRSPEAATEGGAGEVSKERESGDGEAEGDQRAGGYYLEEDTLSEGSGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HEARKDQGDGEDSRSPEAATEGGAGEVSKERESGDGEAEGDQRAGGYYLEEDTLSEGSGV
640 650 660 670 680 690
870 880 890 900 910 920
pF1KF0 ASLEVDCAKEGNPHSSEMEEVAPQPPQPEEMEPEGQPSPDGCLCPCSLGLGGVGMRLAST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASLEVDCAKEGNPHSSEMEEVAPQPPQPEEMEPEGQPSPDGCLCPCSLGLGGVGMRLAST
700 710 720 730 740 750
930 940 950 960 970 980
pF1KF0 LVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVAPANPCPRPGRLDGTPGERAWGSRASRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVAPANPCPRPGRLDGTPGERAWGSRASRS
760 770 780 790 800 810
990 1000 1010 1020 1030 1040
pF1KF0 SWRNGGSLSFDAAVALARDRQRTEAQGVRRTQTCTEGGDYCLIPRTPPCSMISAHSPRPL
:::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::
NP_001 SWRNGGSLSFDAAVALARDRQRTEAQGVRRTQTCTEGGDYCLIPRTSPCSMISAHSPRPL
820 830 840 850 860 870
1050 1060 1070 1080 1090 1100
pF1KF0 SCLELPSEGAEGSGSRSRLSLPPREPQVPDPLLSSQRRSYAFETQANPGKGEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SCLELPSEGAEGSGSRSRLSLPPREPQVPDPLLSSQRRSYAFETQANPGKGEGL
880 890 900 910 920
>>NP_859071 (OMIM: 614264) rho GTPase-activating protein (890 aa)
initn: 4681 init1: 4572 opt: 4572 Z-score: 2518.6 bits: 477.5 E(85289): 1.5e-133
Smith-Waterman score: 5624; 80.6% identity (80.7% similar) in 1101 aa overlap (1-1101:1-890)
10 20 30 40 50 60
pF1KF0 MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_859 MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_859 SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KF0 QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_859 QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KF0 KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_859 KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KF0 PEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_859 PEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KF0 ETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_859 ETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KF0 ENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_859 ENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KF0 PLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_859 PLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEAS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KF0 PASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_859 PASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KF0 FSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSVDSAGPRPEV
::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::
NP_859 FSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KF0 EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_859 EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGED
610 620 630 640 650 660
670 680 690 700 710 720
pF1KF0 KQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKS
:::::::::::::::::.:
NP_859 KQAEPGGRLDIREEAEGTP-----------------------------------------
670
730 740 750 760 770 780
pF1KF0 KGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAE
NP_859 ------------------------------------------------------------
790 800 810 820 830 840
pF1KF0 EKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKERES
NP_859 ------------------------------------------------------------
850 860 870 880 890 900
pF1KF0 GDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEMEP
::::::::::
NP_859 --------------------------------------------------QPPQPEEMEP
680
910 920 930 940 950 960
pF1KF0 EGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_859 EGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVA
690 700 710 720 730 740
970 980 990 1000 1010 1020
pF1KF0 PANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRTQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_859 PANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRTQT
750 760 770 780 790 800
1030 1040 1050 1060 1070 1080
pF1KF0 CTEGGDYCLIPRTPPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDPLL
::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::
NP_859 CTEGGDYCLIPRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDPLL
810 820 830 840 850 860
1090 1100
pF1KF0 SSQRRSYAFETQANPGKGEGL
:::::::::::::::::::::
NP_859 SSQRRSYAFETQANPGKGEGL
870 880 890
>>XP_016856449 (OMIM: 614264) PREDICTED: rho GTPase-acti (967 aa)
initn: 4256 init1: 4256 opt: 4256 Z-score: 2345.2 bits: 445.5 E(85289): 6.9e-124
Smith-Waterman score: 6233; 87.6% identity (87.7% similar) in 1101 aa overlap (1-1101:1-967)
10 20 30 40 50 60
pF1KF0 MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KF0 QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KF0 KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KF0 PEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KF0 ETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESL
:::::::::::::::::::::::::::::::::::::::
XP_016 ETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASD---------------------
310 320 330
370 380 390 400 410 420
pF1KF0 ENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNL
XP_016 ------------------------------------------------------------
430 440 450 460 470 480
pF1KF0 PLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEAS
:::::::
XP_016 -----------------------------------------------------DEKLEAS
340
490 500 510 520 530 540
pF1KF0 PASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAA
350 360 370 380 390 400
550 560 570 580 590 600
pF1KF0 FSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSVDSAGPRPEV
::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::
XP_016 FSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEV
410 420 430 440 450 460
610 620 630 640 650 660
pF1KF0 EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGED
470 480 490 500 510 520
670 680 690 700 710 720
pF1KF0 KQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKS
530 540 550 560 570 580
730 740 750 760 770 780
pF1KF0 KGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAE
590 600 610 620 630 640
790 800 810 820 830 840
pF1KF0 EKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKERES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKERES
650 660 670 680 690 700
850 860 870 880 890 900
pF1KF0 GDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEMEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEMEP
710 720 730 740 750 760
910 920 930 940 950 960
pF1KF0 EGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVA
770 780 790 800 810 820
970 980 990 1000 1010 1020
pF1KF0 PANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRTQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRTQT
830 840 850 860 870 880
1030 1040 1050 1060 1070 1080
pF1KF0 CTEGGDYCLIPRTPPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDPLL
::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CTEGGDYCLIPRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDPLL
890 900 910 920 930 940
1090 1100
pF1KF0 SSQRRSYAFETQANPGKGEGL
:::::::::::::::::::::
XP_016 SSQRRSYAFETQANPGKGEGL
950 960
>>XP_005245127 (OMIM: 614264) PREDICTED: rho GTPase-acti (1044 aa)
initn: 3670 init1: 3670 opt: 3684 Z-score: 2031.7 bits: 387.7 E(85289): 2e-106
Smith-Waterman score: 6922; 94.6% identity (94.7% similar) in 1101 aa overlap (1-1101:1-1044)
10 20 30 40 50 60
pF1KF0 MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KF0 QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KF0 KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KF0 PEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KF0 ETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KF0 ENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KF0 PLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEAS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KF0 PASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAA
::::::::::::::::::::::::::
XP_005 PASSPLADSGPDDLAPALEDSLSQEV----------------------------------
490 500
550 560 570 580 590 600
pF1KF0 FSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSVDSAGPRPEV
:::::::::::::::::::::::::::.:::::::::
XP_005 -----------------------EEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEV
510 520 530 540
610 620 630 640 650 660
pF1KF0 EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGED
550 560 570 580 590 600
670 680 690 700 710 720
pF1KF0 KQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKS
610 620 630 640 650 660
730 740 750 760 770 780
pF1KF0 KGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAE
670 680 690 700 710 720
790 800 810 820 830 840
pF1KF0 EKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKERES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKERES
730 740 750 760 770 780
850 860 870 880 890 900
pF1KF0 GDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEMEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEMEP
790 800 810 820 830 840
910 920 930 940 950 960
pF1KF0 EGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVA
850 860 870 880 890 900
970 980 990 1000 1010 1020
pF1KF0 PANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRTQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRTQT
910 920 930 940 950 960
1030 1040 1050 1060 1070 1080
pF1KF0 CTEGGDYCLIPRTPPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDPLL
::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CTEGGDYCLIPRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDPLL
970 980 990 1000 1010 1020
1090 1100
pF1KF0 SSQRRSYAFETQANPGKGEGL
:::::::::::::::::::::
XP_005 SSQRRSYAFETQANPGKGEGL
1030 1040
>>NP_001166101 (OMIM: 614902) rho GTPase-activating prot (1123 aa)
initn: 1114 init1: 996 opt: 1076 Z-score: 604.2 bits: 123.6 E(85289): 6.5e-27
Smith-Waterman score: 1123; 38.2% identity (57.8% similar) in 702 aa overlap (3-679:162-807)
10 20 30
pF1KF0 MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQE
:::. ...: ..::::::: :::..:::.
NP_001 PQGISSLTSAVPRPRGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQD
140 150 160 170 180 190
40 50 60 70 80 90
pF1KF0 VPQVLKSCAEFVEEYGVVDGIYRLSGVSSNIQKLRQEFESERKPDLRRDVYLQDIHCVSS
:::::. :.::.: .:::::::::::::::::.::.::.::: :.: ..::::: :::
NP_001 VPQVLRCCSEFIEAHGVVDGIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSS
200 210 220 230 240 250
100 110 120 130 140 150
pF1KF0 LCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKILEVLRELPVPNYRTLEFLMRHL
::: ::::::.:::::.:: ::.::..: : ::::.. .:...:: :.:::::.:.:::
NP_001 LCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHL
260 270 280 290 300 310
160 170 180 190 200 210
pF1KF0 VHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVD
..:: ::.:.::::::::::::::::: ..:. :..:.::: ::::::.::::.:::::
NP_001 ARMARHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVD
320 330 340 350 360 370
220 230 240 250 260 270
pF1KF0 QLFGGAALSGGEVESGWRSLPGTRA-SGSPEDLMPRPLPYHLPSILQAGD-GPPQMRPYH
::. . :.: .: :: .. .:: . : : . . : : :
NP_001 VLFSDTFTSAGLDPAGRCLLPRPKSLAGSCPST--RLLTLEEAQARTQGRLGTPTEPTTP
380 390 400 410 420
280 290 300 310 320
pF1KF0 TIIEIAEHKRKG--SLKVRK-----WRSIFNLGRSGHETKRK-LPRGAEDREDKSNKG--
..::: . : :: :...: :::. ..: :: . : . .:
NP_001 KAPASPAERRKGERGEKQRKPGGSSWKTFFALGRGPSVPRKKPLPWLGGTRAPPQPSGSR
430 440 450 460 470 480
330 340 350 360 370
pF1KF0 ----TLRPAKSMDSLSA-AAGAS-DEPEGLVGP-SSPRPSPLLPESLENDSIEAAEGEQE
::: ::: .:::. :.::. .. . : : :: :. : : :. . .
NP_001 PDTVTLRSAKSEESLSSQASGAGLQRLHRLRRPHSSSDAFPVGPA--PAGSCESLSSSSS
490 500 510 520 530 540
380 390 400 410 420 430
pF1KF0 PEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNLPLHITSILSVPPN
:. . ...: . :: .:. .:: . : . .: . . ::
NP_001 SESSSSESSSSSSESSAAGLGAL--SGSPSHRTSAWLDDGDELDFS-----------PPR
550 560 570 580 590
440 450 460 470 480 490
pF1KF0 IISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEASPASSPLADSGPDD
. .. :::. : : : . :.: .:.:: : .: : :
NP_001 CLEGL------RGLDFDPLTFRCSSPTPGDPAPPASPAPPAPASAFPPRVTPQAISPRGP
600 610 620 630 640
500 510 520 530 540
pF1KF0 LAPALEDSLSQEVQDSFSFLEDSSSSEP---EWVGAEDGEVAQAEAAGAAFSPGED-DPG
.:: .: .... .. : : : .:: : :.: . :.:::.. :
NP_001 TSPASPAAL--DISEPLAV-----SVPPAVLELLGA-GGAPASATPT-PALSPGRSLRP-
650 660 670 680 690
550 560 570 580 590 600
pF1KF0 MGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSVDSA-GPR-PEVEEENGEE
.: :: : .: :: : .: : .. .: :: :..:
NP_001 --HLIPLLLRG-------AEAPLTDACQQEM-------CSKLRGAQGPLGPDMESPLPPP
700 710 720 730 740
610 620 630 640 650 660
pF1KF0 VFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGEDKQAEPGG
:: : : .: :: :. . : . : . : ... .: : . .:. :
NP_001 P-LSL---LRPGGAPPPPP-KNPARLMALALAERAQQVAEQQSQQECGGTPPASQS-PFH
750 760 770 780 790
670 680 690 700 710 720
pF1KF0 RLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKSKGQKKAD
: .. :. : :
NP_001 R-SLSLEVGGEPLGTSGSGPPPNSLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRR
800 810 820 830 840 850
>>XP_011524721 (OMIM: 614902) PREDICTED: rho GTPase-acti (1123 aa)
initn: 1114 init1: 996 opt: 1076 Z-score: 604.2 bits: 123.6 E(85289): 6.5e-27
Smith-Waterman score: 1123; 38.2% identity (57.8% similar) in 702 aa overlap (3-679:162-807)
10 20 30
pF1KF0 MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQE
:::. ...: ..::::::: :::..:::.
XP_011 PQGISSLTSAVPRPRGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQD
140 150 160 170 180 190
40 50 60 70 80 90
pF1KF0 VPQVLKSCAEFVEEYGVVDGIYRLSGVSSNIQKLRQEFESERKPDLRRDVYLQDIHCVSS
:::::. :.::.: .:::::::::::::::::.::.::.::: :.: ..::::: :::
XP_011 VPQVLRCCSEFIEAHGVVDGIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSS
200 210 220 230 240 250
100 110 120 130 140 150
pF1KF0 LCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKILEVLRELPVPNYRTLEFLMRHL
::: ::::::.:::::.:: ::.::..: : ::::.. .:...:: :.:::::.:.:::
XP_011 LCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHL
260 270 280 290 300 310
160 170 180 190 200 210
pF1KF0 VHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVD
..:: ::.:.::::::::::::::::: ..:. :..:.::: ::::::.::::.:::::
XP_011 ARMARHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVD
320 330 340 350 360 370
220 230 240 250 260 270
pF1KF0 QLFGGAALSGGEVESGWRSLPGTRA-SGSPEDLMPRPLPYHLPSILQAGD-GPPQMRPYH
::. . :.: .: :: .. .:: . : : . . : : :
XP_011 VLFSDTFTSAGLDPAGRCLLPRPKSLAGSCPST--RLLTLEEAQARTQGRLGTPTEPTTP
380 390 400 410 420
280 290 300 310 320
pF1KF0 TIIEIAEHKRKG--SLKVRK-----WRSIFNLGRSGHETKRK-LPRGAEDREDKSNKG--
..::: . : :: :...: :::. ..: :: . : . .:
XP_011 KAPASPAERRKGERGEKQRKPGGSSWKTFFALGRGPSVPRKKPLPWLGGTRAPPQPSGSR
430 440 450 460 470 480
330 340 350 360 370
pF1KF0 ----TLRPAKSMDSLSA-AAGAS-DEPEGLVGP-SSPRPSPLLPESLENDSIEAAEGEQE
::: ::: .:::. :.::. .. . : : :: :. : : :. . .
XP_011 PDTVTLRSAKSEESLSSQASGAGLQRLHRLRRPHSSSDAFPVGPA--PAGSCESLSSSSS
490 500 510 520 530 540
380 390 400 410 420 430
pF1KF0 PEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNLPLHITSILSVPPN
:. . ...: . :: .:. .:: . : . .: . . ::
XP_011 SESSSSESSSSSSESSAAGLGAL--SGSPSHRTSAWLDDGDELDFS-----------PPR
550 560 570 580 590
440 450 460 470 480 490
pF1KF0 IISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEASPASSPLADSGPDD
. .. :::. : : : . :.: .:.:: : .: : :
XP_011 CLEGL------RGLDFDPLTFRCSSPTPGDPAPPASPAPPAPASAFPPRVTPQAISPRGP
600 610 620 630 640
500 510 520 530 540
pF1KF0 LAPALEDSLSQEVQDSFSFLEDSSSSEP---EWVGAEDGEVAQAEAAGAAFSPGED-DPG
.:: .: .... .. : : : .:: : :.: . :.:::.. :
XP_011 TSPASPAAL--DISEPLAV-----SVPPAVLELLGA-GGAPASATPT-PALSPGRSLRP-
650 660 670 680 690
550 560 570 580 590 600
pF1KF0 MGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSVDSA-GPR-PEVEEENGEE
.: :: : .: :: : .: : .. .: :: :..:
XP_011 --HLIPLLLRG-------AEAPLTDACQQEM-------CSKLRGAQGPLGPDMESPLPPP
700 710 720 730 740
610 620 630 640 650 660
pF1KF0 VFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGEDKQAEPGG
:: : : .: :: :. . : . : . : ... .: : . .:. :
XP_011 P-LSL---LRPGGAPPPPP-KNPARLMALALAERAQQVAEQQSQQECGGTPPASQS-PFH
750 760 770 780 790
670 680 690 700 710 720
pF1KF0 RLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKSKGQKKAD
: .. :. : :
XP_011 R-SLSLEVGGEPLGTSGSGPPPNSLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRR
800 810 820 830 840 850
1101 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 20:08:53 2016 done: Fri Nov 4 20:08:56 2016
Total Scan time: 18.160 Total Display time: 0.390
Function used was FASTA [36.3.4 Apr, 2011]