Result of FASTA (omim) for
pF1KF0386
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KF0386, 674 aa
1>>>pF1KF0386 674 - 674 aa - 674 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 19.7648+/-0.000502; mu= -47.4213+/- 0.031
mean_var=903.3502+/-187.061, 0's: 0 Z-trim(125.7): 124 B-trim: 0 in 0/62
Lambda= 0.042672
statistics sampled from 49776 (49944) to 49776 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.814), E-opt: 0.2 (0.586), width: 16
Scan time: 15.810
The best scores are: opt bits E(85289)
NP_001280165 (OMIM: 607372) mediator of RNA polyme ( 677) 4579 297.3 1.2e-79
XP_016884309 (OMIM: 607372) PREDICTED: mediator of ( 667) 4081 266.6 2.1e-70
NP_001280164 (OMIM: 607372) mediator of RNA polyme ( 722) 4081 266.6 2.2e-70
NP_001280166 (OMIM: 607372) mediator of RNA polyme ( 722) 4081 266.6 2.2e-70
NP_056973 (OMIM: 607372) mediator of RNA polymeras ( 748) 4081 266.7 2.3e-70
XP_006724326 (OMIM: 607372) PREDICTED: mediator of ( 717) 2926 195.5 5.6e-49
XP_016884307 (OMIM: 607372) PREDICTED: mediator of ( 707) 2922 195.3 6.6e-49
XP_016884308 (OMIM: 607372) PREDICTED: mediator of ( 707) 2922 195.3 6.6e-49
XP_006724327 (OMIM: 607372) PREDICTED: mediator of ( 707) 2922 195.3 6.6e-49
XP_011528517 (OMIM: 607372) PREDICTED: mediator of ( 741) 2922 195.3 6.9e-49
XP_016884306 (OMIM: 607372) PREDICTED: mediator of ( 749) 2922 195.3 6.9e-49
XP_011528516 (OMIM: 607372) PREDICTED: mediator of ( 762) 2922 195.3 7e-49
NP_001003891 (OMIM: 607372) mediator of RNA polyme ( 788) 2922 195.3 7.3e-49
NP_001280163 (OMIM: 607372) mediator of RNA polyme ( 731) 2893 193.5 2.3e-48
XP_016884312 (OMIM: 607372) PREDICTED: mediator of ( 404) 2526 170.8 9e-42
XP_016884313 (OMIM: 607372) PREDICTED: mediator of ( 404) 2526 170.8 9e-42
XP_016884311 (OMIM: 607372) PREDICTED: mediator of ( 406) 1576 112.3 3.6e-24
XP_011528521 (OMIM: 607372) PREDICTED: mediator of ( 406) 1576 112.3 3.6e-24
XP_011528522 (OMIM: 607372) PREDICTED: mediator of ( 406) 1576 112.3 3.6e-24
XP_011528520 (OMIM: 607372) PREDICTED: mediator of ( 411) 1571 112.0 4.6e-24
XP_016884310 (OMIM: 607372) PREDICTED: mediator of ( 520) 1571 112.0 5.6e-24
XP_011541326 (OMIM: 607537) PREDICTED: mastermind- ( 928) 496 46.0 0.00076
XP_011541325 (OMIM: 607537) PREDICTED: mastermind- (1009) 496 46.0 0.00081
NP_115803 (OMIM: 607537) mastermind-like protein 2 (1156) 496 46.0 0.00091
XP_011537078 (OMIM: 147920,602113) PREDICTED: hist (5525) 512 47.4 0.0017
XP_006719679 (OMIM: 147920,602113) PREDICTED: hist (5536) 512 47.4 0.0017
XP_005269219 (OMIM: 147920,602113) PREDICTED: hist (5537) 512 47.4 0.0017
NP_003473 (OMIM: 147920,602113) histone-lysine N-m (5537) 512 47.4 0.0017
XP_006719677 (OMIM: 147920,602113) PREDICTED: hist (5540) 512 47.4 0.0017
XP_011537076 (OMIM: 147920,602113) PREDICTED: hist (5549) 512 47.4 0.0017
XP_011537075 (OMIM: 147920,602113) PREDICTED: hist (5552) 512 47.4 0.0017
XP_011537074 (OMIM: 147920,602113) PREDICTED: hist (5553) 512 47.4 0.0017
XP_011537073 (OMIM: 147920,602113) PREDICTED: hist (5555) 512 47.4 0.0017
XP_011537072 (OMIM: 147920,602113) PREDICTED: hist (5556) 512 47.4 0.0017
>>NP_001280165 (OMIM: 607372) mediator of RNA polymerase (677 aa)
initn: 3858 init1: 3858 opt: 4579 Z-score: 1550.6 bits: 297.3 E(85289): 1.2e-79
Smith-Waterman score: 4579; 99.6% identity (99.6% similar) in 677 aa overlap (1-674:1-677)
10 20 30 40 50 60
pF1KF0 MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVA
10 20 30 40 50 60
70 80 90 100 110
pF1KF0 RLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQ--FQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::
NP_001 RLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQA
70 80 90 100 110 120
120 130 140 150 160 170
pF1KF0 QQSAMQQQFQAVVQQQQQLQQQQQQQ-HLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQ
:::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
NP_001 QQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQ
130 140 150 160 170 180
180 190 200 210 220 230
pF1KF0 QQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVA
190 200 210 220 230 240
240 250 260 270 280 290
pF1KF0 QNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQ
250 260 270 280 290 300
300 310 320 330 340 350
pF1KF0 TAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSS
310 320 330 340 350 360
360 370 380 390 400 410
pF1KF0 GPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQ
370 380 390 400 410 420
420 430 440 450 460 470
pF1KF0 YLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIA
430 440 450 460 470 480
480 490 500 510 520 530
pF1KF0 LEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHG
490 500 510 520 530 540
540 550 560 570 580 590
pF1KF0 PPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLD
550 560 570 580 590 600
600 610 620 630 640 650
pF1KF0 DKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTA
610 620 630 640 650 660
660 670
pF1KF0 LLNTWAQSVHQACLSAA
:::::::::::::::::
NP_001 LLNTWAQSVHQACLSAA
670
>>XP_016884309 (OMIM: 607372) PREDICTED: mediator of RNA (667 aa)
initn: 3858 init1: 3858 opt: 4081 Z-score: 1385.0 bits: 266.6 E(85289): 2.1e-70
Smith-Waterman score: 4081; 98.7% identity (99.2% similar) in 604 aa overlap (74-674:64-667)
50 60 70 80 90 100
pF1KF0 HVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQFQQQQQ
: :. ..:::::::::::::::::::::::
XP_016 SLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQ
40 50 60 70 80 90
110 120 130 140 150 160
pF1KF0 AALQQQQQQQQQ--FQAQQSAMQQQFQAVVQQQQQLQQQQQQQ-HLIKLHHQNQQQIQQQ
:::::::::::: ::::::::::::::::::::::::::::: ::::::::::::::::
XP_016 AALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQ
100 110 120 130 140 150
170 180 190 200 210 220
pF1KF0 QQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMH
160 170 180 190 200 210
230 240 250 260 270 280
pF1KF0 HTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVV
220 230 240 250 260 270
290 300 310 320 330 340
pF1KF0 QQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQP
280 290 300 310 320 330
350 360 370 380 390 400
pF1KF0 SPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVN
340 350 360 370 380 390
410 420 430 440 450 460
pF1KF0 PSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILT
400 410 420 430 440 450
470 480 490 500 510 520
pF1KF0 DPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVF
460 470 480 490 500 510
530 540 550 560 570 580
pF1KF0 NHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLD
520 530 540 550 560 570
590 600 610 620 630 640
pF1KF0 PSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHR
580 590 600 610 620 630
650 660 670
pF1KF0 CMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
::::::::::::::::::::::::::::::::::
XP_016 CMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
640 650 660
>>NP_001280164 (OMIM: 607372) mediator of RNA polymerase (722 aa)
initn: 3858 init1: 3858 opt: 4081 Z-score: 1384.5 bits: 266.6 E(85289): 2.2e-70
Smith-Waterman score: 4151; 89.4% identity (89.5% similar) in 706 aa overlap (43-674:17-722)
20 30 40 50 60 70
pF1KF0 TAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNK
::::::::::::::::::::::::::::::
NP_001 MRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNK
10 20 30 40
pF1KF0 KSQASVS-----------------------------------------------------
:::::::
NP_001 KSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPG
50 60 70 80 90 100
80 90 100 110
pF1KF0 ------------------AQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQ--FQAQ
.::::::::::::::::::::::::::::::::::: ::::
NP_001 TSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQ
110 120 130 140 150 160
120 130 140 150 160 170
pF1KF0 QSAMQQQFQAVVQQQQQLQQQQQQQ-HLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQ
::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::
NP_001 QSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQ
170 180 190 200 210 220
180 190 200 210 220 230
pF1KF0 QQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQ
230 240 250 260 270 280
240 250 260 270 280 290
pF1KF0 NQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQT
290 300 310 320 330 340
300 310 320 330 340 350
pF1KF0 AQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSG
350 360 370 380 390 400
360 370 380 390 400 410
pF1KF0 PAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQY
410 420 430 440 450 460
420 430 440 450 460 470
pF1KF0 LDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIAL
470 480 490 500 510 520
480 490 500 510 520 530
pF1KF0 EKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGP
530 540 550 560 570 580
540 550 560 570 580 590
pF1KF0 PITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDD
590 600 610 620 630 640
600 610 620 630 640 650
pF1KF0 KDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTAL
650 660 670 680 690 700
660 670
pF1KF0 LNTWAQSVHQACLSAA
::::::::::::::::
NP_001 LNTWAQSVHQACLSAA
710 720
>>NP_001280166 (OMIM: 607372) mediator of RNA polymerase (722 aa)
initn: 3858 init1: 3858 opt: 4081 Z-score: 1384.5 bits: 266.6 E(85289): 2.2e-70
Smith-Waterman score: 4151; 89.4% identity (89.5% similar) in 706 aa overlap (43-674:17-722)
20 30 40 50 60 70
pF1KF0 TAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNK
::::::::::::::::::::::::::::::
NP_001 MRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNK
10 20 30 40
pF1KF0 KSQASVS-----------------------------------------------------
:::::::
NP_001 KSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPG
50 60 70 80 90 100
80 90 100 110
pF1KF0 ------------------AQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQ--FQAQ
.::::::::::::::::::::::::::::::::::: ::::
NP_001 TSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQ
110 120 130 140 150 160
120 130 140 150 160 170
pF1KF0 QSAMQQQFQAVVQQQQQLQQQQQQQ-HLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQ
::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::
NP_001 QSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQ
170 180 190 200 210 220
180 190 200 210 220 230
pF1KF0 QQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQ
230 240 250 260 270 280
240 250 260 270 280 290
pF1KF0 NQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQT
290 300 310 320 330 340
300 310 320 330 340 350
pF1KF0 AQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSG
350 360 370 380 390 400
360 370 380 390 400 410
pF1KF0 PAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQY
410 420 430 440 450 460
420 430 440 450 460 470
pF1KF0 LDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIAL
470 480 490 500 510 520
480 490 500 510 520 530
pF1KF0 EKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGP
530 540 550 560 570 580
540 550 560 570 580 590
pF1KF0 PITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDD
590 600 610 620 630 640
600 610 620 630 640 650
pF1KF0 KDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTAL
650 660 670 680 690 700
660 670
pF1KF0 LNTWAQSVHQACLSAA
::::::::::::::::
NP_001 LNTWAQSVHQACLSAA
710 720
>>NP_056973 (OMIM: 607372) mediator of RNA polymerase II (748 aa)
initn: 3858 init1: 3858 opt: 4081 Z-score: 1384.2 bits: 266.7 E(85289): 2.3e-70
Smith-Waterman score: 4151; 89.4% identity (89.5% similar) in 706 aa overlap (43-674:43-748)
20 30 40 50 60 70
pF1KF0 TAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNK
::::::::::::::::::::::::::::::
NP_056 TAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNK
20 30 40 50 60 70
pF1KF0 KSQASVS-----------------------------------------------------
:::::::
NP_056 KSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPG
80 90 100 110 120 130
80 90 100 110
pF1KF0 ------------------AQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQ--FQAQ
.::::::::::::::::::::::::::::::::::: ::::
NP_056 TSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQ
140 150 160 170 180 190
120 130 140 150 160 170
pF1KF0 QSAMQQQFQAVVQQQQQLQQQQQQQ-HLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQ
::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::
NP_056 QSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQ
200 210 220 230 240 250
180 190 200 210 220 230
pF1KF0 QQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQ
260 270 280 290 300 310
240 250 260 270 280 290
pF1KF0 NQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 NQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQT
320 330 340 350 360 370
300 310 320 330 340 350
pF1KF0 AQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 AQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSG
380 390 400 410 420 430
360 370 380 390 400 410
pF1KF0 PAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQY
440 450 460 470 480 490
420 430 440 450 460 470
pF1KF0 LDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIAL
500 510 520 530 540 550
480 490 500 510 520 530
pF1KF0 EKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGP
560 570 580 590 600 610
540 550 560 570 580 590
pF1KF0 PITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDD
620 630 640 650 660 670
600 610 620 630 640 650
pF1KF0 KDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTAL
680 690 700 710 720 730
660 670
pF1KF0 LNTWAQSVHQACLSAA
::::::::::::::::
NP_056 LNTWAQSVHQACLSAA
740
>>XP_006724326 (OMIM: 607372) PREDICTED: mediator of RNA (717 aa)
initn: 2710 init1: 2710 opt: 2926 Z-score: 1000.2 bits: 195.5 E(85289): 5.6e-49
Smith-Waterman score: 4408; 93.9% identity (93.9% similar) in 706 aa overlap (12-674:12-717)
10 20 30 40 50 60
pF1KF0 MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVA
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVA
10 20 30 40 50 60
70 80 90 100 110
pF1KF0 RLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQ--FQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::
XP_006 RLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQA
70 80 90 100 110 120
120 130 140 150 160 170
pF1KF0 QQSAMQQQFQAVVQQQQQLQQQQQQQ-HLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQ
:::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
XP_006 QQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQ
130 140 150 160 170 180
180 190 200 210 220 230
pF1KF0 QQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVA
190 200 210 220 230 240
240 250 260 270 280 290
pF1KF0 QNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQ
250 260 270 280 290 300
300 310
pF1KF0 TAQAAQMVAPGVQ----------------------------------------VSQSSLP
::::::::::::: :::::::
XP_006 TAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAIPSSSIPLGRQPMAQVSQSSLP
310 320 330 340 350 360
320 330 340 350 360 370
pF1KF0 MLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQS
370 380 390 400 410 420
380 390 400 410 420 430
pF1KF0 PVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMIN
430 440 450 460 470 480
440 450 460 470 480 490
pF1KF0 KIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPP
490 500 510 520 530 540
500 510 520 530 540 550
pF1KF0 TKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDER
550 560 570 580 590 600
560 570 580 590 600 610
pF1KF0 QSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPA
610 620 630 640 650 660
620 630 640 650 660 670
pF1KF0 QSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
670 680 690 700 710
>>XP_016884307 (OMIM: 607372) PREDICTED: mediator of RNA (707 aa)
initn: 2710 init1: 2710 opt: 2922 Z-score: 999.0 bits: 195.3 E(85289): 6.6e-49
Smith-Waterman score: 3991; 92.5% identity (93.0% similar) in 644 aa overlap (74-674:64-707)
50 60 70 80 90 100
pF1KF0 HVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQFQQQQQ
: :. ..:::::::::::::::::::::::
XP_016 SLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQ
40 50 60 70 80 90
110 120 130 140 150 160
pF1KF0 AALQQQQQQQQQ--FQAQQSAMQQQFQAVVQQQQQLQQQQQQQ-HLIKLHHQNQQQIQQQ
:::::::::::: ::::::::::::::::::::::::::::: ::::::::::::::::
XP_016 AALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQ
100 110 120 130 140 150
170 180 190 200 210 220
pF1KF0 QQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMH
160 170 180 190 200 210
230 240 250 260 270 280
pF1KF0 HTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVV
220 230 240 250 260 270
290 300 310
pF1KF0 QQPPVQPQVQQQQTAVQTAQAAQMVAPGVQ------------------------------
::::::::::::::::::::::::::::::
XP_016 QQPPVQPQVQQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAIPSSS
280 290 300 310 320 330
320 330 340 350 360
pF1KF0 ----------VSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPA
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPA
340 350 360 370 380 390
370 380 390 400 410 420
pF1KF0 PSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLD
400 410 420 430 440 450
430 440 450 460 470 480
pF1KF0 KLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEK
460 470 480 490 500 510
490 500 510 520 530 540
pF1KF0 LKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPI
520 530 540 550 560 570
550 560 570 580 590 600
pF1KF0 TAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKD
580 590 600 610 620 630
610 620 630 640 650 660
pF1KF0 LPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLN
640 650 660 670 680 690
670
pF1KF0 TWAQSVHQACLSAA
::::::::::::::
XP_016 TWAQSVHQACLSAA
700
>>XP_016884308 (OMIM: 607372) PREDICTED: mediator of RNA (707 aa)
initn: 2710 init1: 2710 opt: 2922 Z-score: 999.0 bits: 195.3 E(85289): 6.6e-49
Smith-Waterman score: 3991; 92.5% identity (93.0% similar) in 644 aa overlap (74-674:64-707)
50 60 70 80 90 100
pF1KF0 HVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQFQQQQQ
: :. ..:::::::::::::::::::::::
XP_016 SLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQ
40 50 60 70 80 90
110 120 130 140 150 160
pF1KF0 AALQQQQQQQQQ--FQAQQSAMQQQFQAVVQQQQQLQQQQQQQ-HLIKLHHQNQQQIQQQ
:::::::::::: ::::::::::::::::::::::::::::: ::::::::::::::::
XP_016 AALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQ
100 110 120 130 140 150
170 180 190 200 210 220
pF1KF0 QQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMH
160 170 180 190 200 210
230 240 250 260 270 280
pF1KF0 HTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVV
220 230 240 250 260 270
290 300 310
pF1KF0 QQPPVQPQVQQQQTAVQTAQAAQMVAPGVQ------------------------------
::::::::::::::::::::::::::::::
XP_016 QQPPVQPQVQQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAIPSSS
280 290 300 310 320 330
320 330 340 350 360
pF1KF0 ----------VSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPA
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPA
340 350 360 370 380 390
370 380 390 400 410 420
pF1KF0 PSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLD
400 410 420 430 440 450
430 440 450 460 470 480
pF1KF0 KLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEK
460 470 480 490 500 510
490 500 510 520 530 540
pF1KF0 LKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPI
520 530 540 550 560 570
550 560 570 580 590 600
pF1KF0 TAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKD
580 590 600 610 620 630
610 620 630 640 650 660
pF1KF0 LPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLN
640 650 660 670 680 690
670
pF1KF0 TWAQSVHQACLSAA
::::::::::::::
XP_016 TWAQSVHQACLSAA
700
>>XP_006724327 (OMIM: 607372) PREDICTED: mediator of RNA (707 aa)
initn: 2710 init1: 2710 opt: 2922 Z-score: 999.0 bits: 195.3 E(85289): 6.6e-49
Smith-Waterman score: 3991; 92.5% identity (93.0% similar) in 644 aa overlap (74-674:64-707)
50 60 70 80 90 100
pF1KF0 HVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQFQQQQQ
: :. ..:::::::::::::::::::::::
XP_006 SLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQ
40 50 60 70 80 90
110 120 130 140 150 160
pF1KF0 AALQQQQQQQQQ--FQAQQSAMQQQFQAVVQQQQQLQQQQQQQ-HLIKLHHQNQQQIQQQ
:::::::::::: ::::::::::::::::::::::::::::: ::::::::::::::::
XP_006 AALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQ
100 110 120 130 140 150
170 180 190 200 210 220
pF1KF0 QQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMH
160 170 180 190 200 210
230 240 250 260 270 280
pF1KF0 HTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVV
220 230 240 250 260 270
290 300 310
pF1KF0 QQPPVQPQVQQQQTAVQTAQAAQMVAPGVQ------------------------------
::::::::::::::::::::::::::::::
XP_006 QQPPVQPQVQQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAIPSSS
280 290 300 310 320 330
320 330 340 350 360
pF1KF0 ----------VSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPA
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPA
340 350 360 370 380 390
370 380 390 400 410 420
pF1KF0 PSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLD
400 410 420 430 440 450
430 440 450 460 470 480
pF1KF0 KLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEK
460 470 480 490 500 510
490 500 510 520 530 540
pF1KF0 LKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPI
520 530 540 550 560 570
550 560 570 580 590 600
pF1KF0 TAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKD
580 590 600 610 620 630
610 620 630 640 650 660
pF1KF0 LPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLN
640 650 660 670 680 690
670
pF1KF0 TWAQSVHQACLSAA
::::::::::::::
XP_006 TWAQSVHQACLSAA
700
>>XP_011528517 (OMIM: 607372) PREDICTED: mediator of RNA (741 aa)
initn: 2710 init1: 2710 opt: 2922 Z-score: 998.7 bits: 195.3 E(85289): 6.9e-49
Smith-Waterman score: 3991; 92.5% identity (93.0% similar) in 644 aa overlap (74-674:98-741)
50 60 70 80 90 100
pF1KF0 HVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQFQQQQQ
: :. ..:::::::::::::::::::::::
XP_011 SLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQ
70 80 90 100 110 120
110 120 130 140 150 160
pF1KF0 AALQQQQQQQQQ--FQAQQSAMQQQFQAVVQQQQQLQQQQQQQ-HLIKLHHQNQQQIQQQ
:::::::::::: ::::::::::::::::::::::::::::: ::::::::::::::::
XP_011 AALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQ
130 140 150 160 170 180
170 180 190 200 210 220
pF1KF0 QQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMH
190 200 210 220 230 240
230 240 250 260 270 280
pF1KF0 HTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVV
250 260 270 280 290 300
290 300 310
pF1KF0 QQPPVQPQVQQQQTAVQTAQAAQMVAPGVQ------------------------------
::::::::::::::::::::::::::::::
XP_011 QQPPVQPQVQQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAIPSSS
310 320 330 340 350 360
320 330 340 350 360
pF1KF0 ----------VSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPA
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPA
370 380 390 400 410 420
370 380 390 400 410 420
pF1KF0 PSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLD
430 440 450 460 470 480
430 440 450 460 470 480
pF1KF0 KLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEK
490 500 510 520 530 540
490 500 510 520 530 540
pF1KF0 LKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPI
550 560 570 580 590 600
550 560 570 580 590 600
pF1KF0 TAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKD
610 620 630 640 650 660
610 620 630 640 650 660
pF1KF0 LPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLN
670 680 690 700 710 720
670
pF1KF0 TWAQSVHQACLSAA
::::::::::::::
XP_011 TWAQSVHQACLSAA
730 740
674 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 20:11:37 2016 done: Fri Nov 4 20:11:39 2016
Total Scan time: 15.810 Total Display time: 0.160
Function used was FASTA [36.3.4 Apr, 2011]