FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0063, 202 aa 1>>>pF1KSDA0063 202 - 202 aa - 202 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9817+/-0.000295; mu= 14.7548+/- 0.018 mean_var=57.5728+/-11.891, 0's: 0 Z-trim(116.7): 20 B-trim: 0 in 0/56 Lambda= 0.169031 statistics sampled from 28055 (28075) to 28055 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.726), E-opt: 0.2 (0.329), width: 16 Scan time: 4.780 The best scores are: opt bits E(85289) XP_005261934 (OMIM: 615323) PREDICTED: josephin-1 ( 202) 1405 350.3 1.2e-96 XP_005261933 (OMIM: 615323) PREDICTED: josephin-1 ( 202) 1405 350.3 1.2e-96 XP_005261936 (OMIM: 615323) PREDICTED: josephin-1 ( 202) 1405 350.3 1.2e-96 XP_005261935 (OMIM: 615323) PREDICTED: josephin-1 ( 202) 1405 350.3 1.2e-96 NP_055691 (OMIM: 615323) josephin-1 [Homo sapiens] ( 202) 1405 350.3 1.2e-96 NP_001257568 (OMIM: 615324) josephin-2 isoform 1 [ ( 188) 677 172.8 3.1e-43 NP_001257569 (OMIM: 615324) josephin-2 isoform 1 [ ( 188) 677 172.8 3.1e-43 NP_612207 (OMIM: 615324) josephin-2 isoform 1 [Hom ( 188) 677 172.8 3.1e-43 XP_011524736 (OMIM: 615324) PREDICTED: josephin-2 ( 188) 677 172.8 3.1e-43 NP_001257615 (OMIM: 615324) josephin-2 isoform 1 [ ( 188) 677 172.8 3.1e-43 NP_001257570 (OMIM: 615324) josephin-2 isoform 2 [ ( 146) 331 88.3 6.4e-18 NP_004984 (OMIM: 109150,607047) ataxin-3 reference ( 361) 134 40.5 0.004 >>XP_005261934 (OMIM: 615323) PREDICTED: josephin-1 isof (202 aa) initn: 1405 init1: 1405 opt: 1405 Z-score: 1856.1 bits: 350.3 E(85289): 1.2e-96 Smith-Waterman score: 1405; 100.0% identity (100.0% similar) in 202 aa overlap (1-202:1-202) 10 20 30 40 50 60 pF1KSD MSCVPWKGDKAKSESLELPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRDTLQEIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSCVPWKGDKAKSESLELPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRDTLQEIF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD QRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVGVIALTNVMGFIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVGVIALTNVMGFIM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD NLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKHHLRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKHHLRGK 130 140 150 160 170 180 190 200 pF1KSD NCELLLVVPEEVEAHQSWRTDV :::::::::::::::::::::: XP_005 NCELLLVVPEEVEAHQSWRTDV 190 200 >>XP_005261933 (OMIM: 615323) PREDICTED: josephin-1 isof (202 aa) initn: 1405 init1: 1405 opt: 1405 Z-score: 1856.1 bits: 350.3 E(85289): 1.2e-96 Smith-Waterman score: 1405; 100.0% identity (100.0% similar) in 202 aa overlap (1-202:1-202) 10 20 30 40 50 60 pF1KSD MSCVPWKGDKAKSESLELPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRDTLQEIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSCVPWKGDKAKSESLELPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRDTLQEIF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD QRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVGVIALTNVMGFIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVGVIALTNVMGFIM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD NLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKHHLRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKHHLRGK 130 140 150 160 170 180 190 200 pF1KSD NCELLLVVPEEVEAHQSWRTDV :::::::::::::::::::::: XP_005 NCELLLVVPEEVEAHQSWRTDV 190 200 >>XP_005261936 (OMIM: 615323) PREDICTED: josephin-1 isof (202 aa) initn: 1405 init1: 1405 opt: 1405 Z-score: 1856.1 bits: 350.3 E(85289): 1.2e-96 Smith-Waterman score: 1405; 100.0% identity (100.0% similar) in 202 aa overlap (1-202:1-202) 10 20 30 40 50 60 pF1KSD MSCVPWKGDKAKSESLELPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRDTLQEIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSCVPWKGDKAKSESLELPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRDTLQEIF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD QRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVGVIALTNVMGFIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVGVIALTNVMGFIM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD NLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKHHLRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKHHLRGK 130 140 150 160 170 180 190 200 pF1KSD NCELLLVVPEEVEAHQSWRTDV :::::::::::::::::::::: XP_005 NCELLLVVPEEVEAHQSWRTDV 190 200 >>XP_005261935 (OMIM: 615323) PREDICTED: josephin-1 isof (202 aa) initn: 1405 init1: 1405 opt: 1405 Z-score: 1856.1 bits: 350.3 E(85289): 1.2e-96 Smith-Waterman score: 1405; 100.0% identity (100.0% similar) in 202 aa overlap (1-202:1-202) 10 20 30 40 50 60 pF1KSD MSCVPWKGDKAKSESLELPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRDTLQEIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSCVPWKGDKAKSESLELPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRDTLQEIF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD QRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVGVIALTNVMGFIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVGVIALTNVMGFIM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD NLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKHHLRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKHHLRGK 130 140 150 160 170 180 190 200 pF1KSD NCELLLVVPEEVEAHQSWRTDV :::::::::::::::::::::: XP_005 NCELLLVVPEEVEAHQSWRTDV 190 200 >>NP_055691 (OMIM: 615323) josephin-1 [Homo sapiens] (202 aa) initn: 1405 init1: 1405 opt: 1405 Z-score: 1856.1 bits: 350.3 E(85289): 1.2e-96 Smith-Waterman score: 1405; 100.0% identity (100.0% similar) in 202 aa overlap (1-202:1-202) 10 20 30 40 50 60 pF1KSD MSCVPWKGDKAKSESLELPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRDTLQEIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MSCVPWKGDKAKSESLELPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRDTLQEIF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD QRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVGVIALTNVMGFIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 QRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVGVIALTNVMGFIM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD NLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKHHLRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 NLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKHHLRGK 130 140 150 160 170 180 190 200 pF1KSD NCELLLVVPEEVEAHQSWRTDV :::::::::::::::::::::: NP_055 NCELLLVVPEEVEAHQSWRTDV 190 200 >>NP_001257568 (OMIM: 615324) josephin-2 isoform 1 [Homo (188 aa) initn: 613 init1: 482 opt: 677 Z-score: 897.1 bits: 172.8 E(85289): 3.1e-43 Smith-Waterman score: 677; 55.2% identity (79.2% similar) in 183 aa overlap (20-201:8-188) 10 20 30 40 50 60 pF1KSD MSCVPWKGDKAKSESLELPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRDTLQEIF : .:: .:::.:: ::::.::::::.:.. :.... .:: NP_001 MSQAPGAQPSPPTVYHERQRLELCAVHALNNVLQQQ-LFSQEAADEIC 10 20 30 40 70 80 90 100 110 120 pF1KSD QRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVGVIALTNVMGFIM .::.:.. ..::. :.::.::::::::::::: : :::::.:: .. .:: .:.:.:. NP_001 KRLAPDSRLNPHR-SLLGTGNYDVNVIMAALQGLGLAAVWWDRRRPLSQLALPQVLGLIL 50 60 70 80 90 100 130 140 150 160 170 180 pF1KSD NLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKHHLRGK :::: . : :.:::.:.::. .:.: :.::::::::. :: .: :. .: :: : NP_001 NLPSPVSLGLLSLPLRRRHWVALRQVDGVYYNLDSKLRAPEALGDEDGVRAFLAAALAQG 110 120 130 140 150 160 190 200 pF1KSD NCELLLVVPEEVEAHQSW-RTDV ::.:::: .::: . :: ::: NP_001 LCEVLLVVTKEVEEKGSWLRTD 170 180 >>NP_001257569 (OMIM: 615324) josephin-2 isoform 1 [Homo (188 aa) initn: 613 init1: 482 opt: 677 Z-score: 897.1 bits: 172.8 E(85289): 3.1e-43 Smith-Waterman score: 677; 55.2% identity (79.2% similar) in 183 aa overlap (20-201:8-188) 10 20 30 40 50 60 pF1KSD MSCVPWKGDKAKSESLELPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRDTLQEIF : .:: .:::.:: ::::.::::::.:.. :.... .:: NP_001 MSQAPGAQPSPPTVYHERQRLELCAVHALNNVLQQQ-LFSQEAADEIC 10 20 30 40 70 80 90 100 110 120 pF1KSD QRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVGVIALTNVMGFIM .::.:.. ..::. :.::.::::::::::::: : :::::.:: .. .:: .:.:.:. NP_001 KRLAPDSRLNPHR-SLLGTGNYDVNVIMAALQGLGLAAVWWDRRRPLSQLALPQVLGLIL 50 60 70 80 90 100 130 140 150 160 170 180 pF1KSD NLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKHHLRGK :::: . : :.:::.:.::. .:.: :.::::::::. :: .: :. .: :: : NP_001 NLPSPVSLGLLSLPLRRRHWVALRQVDGVYYNLDSKLRAPEALGDEDGVRAFLAAALAQG 110 120 130 140 150 160 190 200 pF1KSD NCELLLVVPEEVEAHQSW-RTDV ::.:::: .::: . :: ::: NP_001 LCEVLLVVTKEVEEKGSWLRTD 170 180 >>NP_612207 (OMIM: 615324) josephin-2 isoform 1 [Homo sa (188 aa) initn: 613 init1: 482 opt: 677 Z-score: 897.1 bits: 172.8 E(85289): 3.1e-43 Smith-Waterman score: 677; 55.2% identity (79.2% similar) in 183 aa overlap (20-201:8-188) 10 20 30 40 50 60 pF1KSD MSCVPWKGDKAKSESLELPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRDTLQEIF : .:: .:::.:: ::::.::::::.:.. :.... .:: NP_612 MSQAPGAQPSPPTVYHERQRLELCAVHALNNVLQQQ-LFSQEAADEIC 10 20 30 40 70 80 90 100 110 120 pF1KSD QRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVGVIALTNVMGFIM .::.:.. ..::. :.::.::::::::::::: : :::::.:: .. .:: .:.:.:. NP_612 KRLAPDSRLNPHR-SLLGTGNYDVNVIMAALQGLGLAAVWWDRRRPLSQLALPQVLGLIL 50 60 70 80 90 100 130 140 150 160 170 180 pF1KSD NLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKHHLRGK :::: . : :.:::.:.::. .:.: :.::::::::. :: .: :. .: :: : NP_612 NLPSPVSLGLLSLPLRRRHWVALRQVDGVYYNLDSKLRAPEALGDEDGVRAFLAAALAQG 110 120 130 140 150 160 190 200 pF1KSD NCELLLVVPEEVEAHQSW-RTDV ::.:::: .::: . :: ::: NP_612 LCEVLLVVTKEVEEKGSWLRTD 170 180 >>XP_011524736 (OMIM: 615324) PREDICTED: josephin-2 isof (188 aa) initn: 613 init1: 482 opt: 677 Z-score: 897.1 bits: 172.8 E(85289): 3.1e-43 Smith-Waterman score: 677; 55.2% identity (79.2% similar) in 183 aa overlap (20-201:8-188) 10 20 30 40 50 60 pF1KSD MSCVPWKGDKAKSESLELPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRDTLQEIF : .:: .:::.:: ::::.::::::.:.. :.... .:: XP_011 MSQAPGAQPSPPTVYHERQRLELCAVHALNNVLQQQ-LFSQEAADEIC 10 20 30 40 70 80 90 100 110 120 pF1KSD QRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVGVIALTNVMGFIM .::.:.. ..::. :.::.::::::::::::: : :::::.:: .. .:: .:.:.:. XP_011 KRLAPDSRLNPHR-SLLGTGNYDVNVIMAALQGLGLAAVWWDRRRPLSQLALPQVLGLIL 50 60 70 80 90 100 130 140 150 160 170 180 pF1KSD NLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKHHLRGK :::: . : :.:::.:.::. .:.: :.::::::::. :: .: :. .: :: : XP_011 NLPSPVSLGLLSLPLRRRHWVALRQVDGVYYNLDSKLRAPEALGDEDGVRAFLAAALAQG 110 120 130 140 150 160 190 200 pF1KSD NCELLLVVPEEVEAHQSW-RTDV ::.:::: .::: . :: ::: XP_011 LCEVLLVVTKEVEEKGSWLRTD 170 180 >>NP_001257615 (OMIM: 615324) josephin-2 isoform 1 [Homo (188 aa) initn: 613 init1: 482 opt: 677 Z-score: 897.1 bits: 172.8 E(85289): 3.1e-43 Smith-Waterman score: 677; 55.2% identity (79.2% similar) in 183 aa overlap (20-201:8-188) 10 20 30 40 50 60 pF1KSD MSCVPWKGDKAKSESLELPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRDTLQEIF : .:: .:::.:: ::::.::::::.:.. :.... .:: NP_001 MSQAPGAQPSPPTVYHERQRLELCAVHALNNVLQQQ-LFSQEAADEIC 10 20 30 40 70 80 90 100 110 120 pF1KSD QRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVGVIALTNVMGFIM .::.:.. ..::. :.::.::::::::::::: : :::::.:: .. .:: .:.:.:. NP_001 KRLAPDSRLNPHR-SLLGTGNYDVNVIMAALQGLGLAAVWWDRRRPLSQLALPQVLGLIL 50 60 70 80 90 100 130 140 150 160 170 180 pF1KSD NLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKHHLRGK :::: . : :.:::.:.::. .:.: :.::::::::. :: .: :. .: :: : NP_001 NLPSPVSLGLLSLPLRRRHWVALRQVDGVYYNLDSKLRAPEALGDEDGVRAFLAAALAQG 110 120 130 140 150 160 190 200 pF1KSD NCELLLVVPEEVEAHQSW-RTDV ::.:::: .::: . :: ::: NP_001 LCEVLLVVTKEVEEKGSWLRTD 170 180 202 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 23:41:44 2016 done: Wed Nov 2 23:41:44 2016 Total Scan time: 4.780 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]