FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0067, 1291 aa 1>>>pF1KSDA0067 1291 - 1291 aa - 1291 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.3932+/-0.000439; mu= -9.5760+/- 0.027 mean_var=378.8531+/-78.839, 0's: 0 Z-trim(121.4): 52 B-trim: 1893 in 2/56 Lambda= 0.065893 statistics sampled from 37876 (37936) to 37876 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.739), E-opt: 0.2 (0.445), width: 16 Scan time: 16.390 The best scores are: opt bits E(85289) NP_001138887 (OMIM: 604396) histone-lysine N-methy (1291) 8782 850.0 0 XP_005245698 (OMIM: 604396) PREDICTED: histone-lys (1292) 8764 848.3 0 XP_016858442 (OMIM: 604396) PREDICTED: histone-lys (1292) 8764 848.3 0 NP_036564 (OMIM: 604396) histone-lysine N-methyltr (1290) 8763 848.2 0 XP_016858443 (OMIM: 604396) PREDICTED: histone-lys ( 739) 4983 488.7 6.3e-137 XP_016858444 (OMIM: 604396) PREDICTED: histone-lys ( 397) 2495 252.0 6e-66 NP_001230420 (OMIM: 604396) histone-lysine N-methy ( 397) 2495 252.0 6e-66 NP_001153780 (OMIM: 607865) histone-lysine N-methy ( 707) 857 96.5 7.2e-19 NP_001307628 (OMIM: 607865) histone-lysine N-methy ( 707) 857 96.5 7.2e-19 NP_114121 (OMIM: 607865) histone-lysine N-methyltr ( 719) 857 96.5 7.3e-19 >>NP_001138887 (OMIM: 604396) histone-lysine N-methyltra (1291 aa) initn: 8782 init1: 8782 opt: 8782 Z-score: 4527.5 bits: 850.0 E(85289): 0 Smith-Waterman score: 8782; 100.0% identity (100.0% similar) in 1291 aa overlap (1-1291:1-1291) 10 20 30 40 50 60 pF1KSD MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD AQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRME 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD AEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKT 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD SMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD EGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQF 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD YDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTE 1210 1220 1230 1240 1250 1260 1270 1280 1290 pF1KSD LTWDYNYEVGSVEGKELLCCCGAIECRGRLL ::::::::::::::::::::::::::::::: NP_001 LTWDYNYEVGSVEGKELLCCCGAIECRGRLL 1270 1280 1290 >>XP_005245698 (OMIM: 604396) PREDICTED: histone-lysine (1292 aa) initn: 8762 init1: 5619 opt: 8764 Z-score: 4518.3 bits: 848.3 E(85289): 0 Smith-Waterman score: 8764; 99.8% identity (99.9% similar) in 1292 aa overlap (1-1291:1-1292) 10 20 30 40 50 60 pF1KSD MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP 370 380 390 400 410 420 430 440 450 460 470 pF1KSD NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSD-LESQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::. :::: XP_005 NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSESLESQ 430 440 450 460 470 480 480 490 500 510 520 530 pF1KSD LAQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LAQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAP 490 500 510 520 530 540 540 550 560 570 580 590 pF1KSD SALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNP 550 560 570 580 590 600 600 610 620 630 640 650 pF1KSD LLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFC 610 620 630 640 650 660 660 670 680 690 700 710 pF1KSD LDPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LDPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFI 670 680 690 700 710 720 720 730 740 750 760 770 pF1KSD NTGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NTGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVY 730 740 750 760 770 780 780 790 800 810 820 830 pF1KSD ECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTD 790 800 810 820 830 840 840 850 860 870 880 890 pF1KSD DFADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DFADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPE 850 860 870 880 890 900 900 910 920 930 940 950 pF1KSD ESNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ESNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPV 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KSD PPSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRM 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KSD EAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSK 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KSD TSMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TSMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSG 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KSD SEGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SEGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQ 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KSD FYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGT 1210 1220 1230 1240 1250 1260 1260 1270 1280 1290 pF1KSD ELTWDYNYEVGSVEGKELLCCCGAIECRGRLL :::::::::::::::::::::::::::::::: XP_005 ELTWDYNYEVGSVEGKELLCCCGAIECRGRLL 1270 1280 1290 >>XP_016858442 (OMIM: 604396) PREDICTED: histone-lysine (1292 aa) initn: 8762 init1: 5619 opt: 8764 Z-score: 4518.3 bits: 848.3 E(85289): 0 Smith-Waterman score: 8764; 99.8% identity (99.9% similar) in 1292 aa overlap (1-1291:1-1292) 10 20 30 40 50 60 pF1KSD MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP 370 380 390 400 410 420 430 440 450 460 470 pF1KSD NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSD-LESQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::. :::: XP_016 NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSESLESQ 430 440 450 460 470 480 480 490 500 510 520 530 pF1KSD LAQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAP 490 500 510 520 530 540 540 550 560 570 580 590 pF1KSD SALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNP 550 560 570 580 590 600 600 610 620 630 640 650 pF1KSD LLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFC 610 620 630 640 650 660 660 670 680 690 700 710 pF1KSD LDPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFI 670 680 690 700 710 720 720 730 740 750 760 770 pF1KSD NTGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NTGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVY 730 740 750 760 770 780 780 790 800 810 820 830 pF1KSD ECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTD 790 800 810 820 830 840 840 850 860 870 880 890 pF1KSD DFADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DFADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPE 850 860 870 880 890 900 900 910 920 930 940 950 pF1KSD ESNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPV 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KSD PPSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRM 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KSD EAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSK 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KSD TSMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSG 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KSD SEGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQ 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KSD FYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGT 1210 1220 1230 1240 1250 1260 1260 1270 1280 1290 pF1KSD ELTWDYNYEVGSVEGKELLCCCGAIECRGRLL :::::::::::::::::::::::::::::::: XP_016 ELTWDYNYEVGSVEGKELLCCCGAIECRGRLL 1270 1280 1290 >>NP_036564 (OMIM: 604396) histone-lysine N-methyltransf (1290 aa) initn: 8510 init1: 8510 opt: 8763 Z-score: 4517.8 bits: 848.2 E(85289): 0 Smith-Waterman score: 8763; 99.9% identity (99.9% similar) in 1291 aa overlap (1-1291:1-1290) 10 20 30 40 50 60 pF1KSD MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD AQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 AQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRME 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD AEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 AEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKT 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD SMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 SMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD EGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 EGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQF 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD YDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTE ::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::: NP_036 YDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASK-IRAGTE 1210 1220 1230 1240 1250 1270 1280 1290 pF1KSD LTWDYNYEVGSVEGKELLCCCGAIECRGRLL ::::::::::::::::::::::::::::::: NP_036 LTWDYNYEVGSVEGKELLCCCGAIECRGRLL 1260 1270 1280 1290 >>XP_016858443 (OMIM: 604396) PREDICTED: histone-lysine (739 aa) initn: 4981 init1: 3157 opt: 4983 Z-score: 2579.3 bits: 488.7 E(85289): 6.3e-137 Smith-Waterman score: 4983; 99.7% identity (99.9% similar) in 739 aa overlap (1-738:1-739) 10 20 30 40 50 60 pF1KSD MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP 370 380 390 400 410 420 430 440 450 460 470 pF1KSD NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSD-LESQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::. :::: XP_016 NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSESLESQ 430 440 450 460 470 480 480 490 500 510 520 530 pF1KSD LAQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAP 490 500 510 520 530 540 540 550 560 570 580 590 pF1KSD SALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNP 550 560 570 580 590 600 600 610 620 630 640 650 pF1KSD LLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFC 610 620 630 640 650 660 660 670 680 690 700 710 pF1KSD LDPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFI 670 680 690 700 710 720 720 730 740 750 760 770 pF1KSD NTGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVY ::::::::::::::::::: XP_016 NTGPEFLVGCDCKDGCRDK 730 >>XP_016858444 (OMIM: 604396) PREDICTED: histone-lysine (397 aa) initn: 2495 init1: 2495 opt: 2495 Z-score: 1305.0 bits: 252.0 E(85289): 6e-66 Smith-Waterman score: 2495; 100.0% identity (100.0% similar) in 380 aa overlap (1-380:1-380) 10 20 30 40 50 60 pF1KSD MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP :::::::::::::::::::: XP_016 TWWKSRVEEVDGSLVRILFLVLFFSTILEAEVGGGGT 370 380 390 >>NP_001230420 (OMIM: 604396) histone-lysine N-methyltra (397 aa) initn: 2495 init1: 2495 opt: 2495 Z-score: 1305.0 bits: 252.0 E(85289): 6e-66 Smith-Waterman score: 2495; 100.0% identity (100.0% similar) in 380 aa overlap (1-380:1-380) 10 20 30 40 50 60 pF1KSD MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP :::::::::::::::::::: NP_001 TWWKSRVEEVDGSLVRILFLVLFFSTILEAEVGGGGT 370 380 390 >>NP_001153780 (OMIM: 607865) histone-lysine N-methyltra (707 aa) initn: 1181 init1: 764 opt: 857 Z-score: 459.8 bits: 96.5 E(85289): 7.2e-19 Smith-Waterman score: 1038; 31.4% identity (55.3% similar) in 722 aa overlap (571-1291:128-707) 550 560 570 580 590 600 pF1KSD ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL : : : :: .:: .. :. . .:.::: NP_001 DCTFLTTENKEILSLEDKVVDFREKDSSSNLSYQSHDCSGACLMKM-PL---NLKGENPL 100 110 120 130 140 150 610 620 630 640 650 660 pF1KSD LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL .:. :.: :. ... ..:: :::::: ::...:. :::.:: :.::: . : . NP_001 QLPIKCHFQRRHAKTN-SHSSALHVSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSF 160 170 180 190 200 210 670 680 690 700 710 720 pF1KSD DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN . :: . :.. : .::. : :.::.: ::::. :: : : : . : NP_001 NTYVQLARNYPKQKEVVSDVDISNGVESVPISFCNEIDSRKLPQFKYRKTVWPRAYNLTN 220 230 240 250 260 270 730 740 750 760 770 780 pF1KSD TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE . : .:::..:: : .:::: ::: . . .: .. . ..::.::::.. .:::.:: NP_001 FSSMFTDSCDCSEGCIDITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYE 280 290 300 310 320 330 790 800 810 820 830 840 pF1KSD CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD :. :::. ..: ::.:::: :::::.:::..::::.:::::: .:.:::::.:..:. NP_001 CSLLCKCNRQLCQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSR- 340 350 360 370 380 390 850 860 870 880 890 900 pF1KSD FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE :. : :: . . .... :.. . .. ::. NP_001 -ANTEKSYGIDENGRDENTMKNI--FSKKRKLEVACSD---------------------- 400 410 420 910 920 930 940 950 960 pF1KSD SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP :. : . :: ..:: . : NP_001 ----------CEVEVLPL-------------------GL------ETHPRTAKTEKCP-- 430 440 970 980 990 1000 1010 pF1KSD PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSS-FKTNEGGEGRAGGSRM : . :: : : .. .:: . : .:... :. : :..: NP_001 ---PKFSNNPKELTVETKYDNISRIQYHSV----IRDPESKTAIFQHN--------GKKM 450 460 470 480 490 1020 1030 1040 1050 1060 1070 pF1KSD EAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSK : .:. .. .:. .: . : ....: .. .:: :. NP_001 EF--VSSESVTPEDNDGFKPPR-EHLNSKTK-GAQKDSSSNH------------------ 500 510 520 530 1080 1090 1100 1110 1120 1130 pF1KSD TSMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSG .. .. :. : ::. ... : :. : . ..::..:...:. NP_001 VDEFEDNLLIES------DVIDITKYRE---ET----PPRSRCNQATTLDNQNIK----- 540 550 560 570 1140 1150 1160 1170 1180 1190 pF1KSD SEGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQ .. . . .: . : :..: . . : . .. : :. :. . . NP_001 -KAIEVQIQKPQEG---RSTACQRQQVFC----------DEELLSETKNTSSD---SLTK 580 590 600 610 1200 1210 1220 1230 1240 1250 pF1KSD FYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGT : : . ...:: :::.::.::::: :::.::::::.::. :: ::::... ..: : NP_001 FNKG--NVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKART 620 630 640 650 660 670 1260 1270 1280 1290 pF1KSD ELTWDYNYEVGSVEGKELLCCCGAIECRGRLL ::::::.::.:.: ::..: ::. .:: ..: NP_001 ELTWDYGYEAGTVPEKEIFCQCGVNKCRKKIL 680 690 700 >>NP_001307628 (OMIM: 607865) histone-lysine N-methyltra (707 aa) initn: 1181 init1: 764 opt: 857 Z-score: 459.8 bits: 96.5 E(85289): 7.2e-19 Smith-Waterman score: 1038; 31.4% identity (55.3% similar) in 722 aa overlap (571-1291:128-707) 550 560 570 580 590 600 pF1KSD ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL : : : :: .:: .. :. . .:.::: NP_001 DCTFLTTENKEILSLEDKVVDFREKDSSSNLSYQSHDCSGACLMKM-PL---NLKGENPL 100 110 120 130 140 150 610 620 630 640 650 660 pF1KSD LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL .:. :.: :. ... ..:: :::::: ::...:. :::.:: :.::: . : . NP_001 QLPIKCHFQRRHAKTN-SHSSALHVSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSF 160 170 180 190 200 210 670 680 690 700 710 720 pF1KSD DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN . :: . :.. : .::. : :.::.: ::::. :: : : : . : NP_001 NTYVQLARNYPKQKEVVSDVDISNGVESVPISFCNEIDSRKLPQFKYRKTVWPRAYNLTN 220 230 240 250 260 270 730 740 750 760 770 780 pF1KSD TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE . : .:::..:: : .:::: ::: . . .: .. . ..::.::::.. .:::.:: NP_001 FSSMFTDSCDCSEGCIDITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYE 280 290 300 310 320 330 790 800 810 820 830 840 pF1KSD CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD :. :::. ..: ::.:::: :::::.:::..::::.:::::: .:.:::::.:..:. NP_001 CSLLCKCNRQLCQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSR- 340 350 360 370 380 390 850 860 870 880 890 900 pF1KSD FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE :. : :: . . .... :.. . .. ::. NP_001 -ANTEKSYGIDENGRDENTMKNI--FSKKRKLEVACSD---------------------- 400 410 420 910 920 930 940 950 960 pF1KSD SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP :. : . :: ..:: . : NP_001 ----------CEVEVLPL-------------------GL------ETHPRTAKTEKCP-- 430 440 970 980 990 1000 1010 pF1KSD PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSS-FKTNEGGEGRAGGSRM : . :: : : .. .:: . : .:... :. : :..: NP_001 ---PKFSNNPKELTVETKYDNISRIQYHSV----IRDPESKTAIFQHN--------GKKM 450 460 470 480 490 1020 1030 1040 1050 1060 1070 pF1KSD EAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSK : .:. .. .:. .: . : ....: .. .:: :. NP_001 EF--VSSESVTPEDNDGFKPPR-EHLNSKTK-GAQKDSSSNH------------------ 500 510 520 530 1080 1090 1100 1110 1120 1130 pF1KSD TSMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSG .. .. :. : ::. ... : :. : . ..::..:...:. NP_001 VDEFEDNLLIES------DVIDITKYRE---ET----PPRSRCNQATTLDNQNIK----- 540 550 560 570 1140 1150 1160 1170 1180 1190 pF1KSD SEGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQ .. . . .: . : :..: . . : . .. : :. :. . . NP_001 -KAIEVQIQKPQEG---RSTACQRQQVFC----------DEELLSETKNTSSD---SLTK 580 590 600 610 1200 1210 1220 1230 1240 1250 pF1KSD FYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGT : : . ...:: :::.::.::::: :::.::::::.::. :: ::::... ..: : NP_001 FNKG--NVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKART 620 630 640 650 660 670 1260 1270 1280 1290 pF1KSD ELTWDYNYEVGSVEGKELLCCCGAIECRGRLL ::::::.::.:.: ::..: ::. .:: ..: NP_001 ELTWDYGYEAGTVPEKEIFCQCGVNKCRKKIL 680 690 700 >>NP_114121 (OMIM: 607865) histone-lysine N-methyltransf (719 aa) initn: 1181 init1: 764 opt: 857 Z-score: 459.7 bits: 96.5 E(85289): 7.3e-19 Smith-Waterman score: 1038; 31.4% identity (55.3% similar) in 722 aa overlap (571-1291:140-719) 550 560 570 580 590 600 pF1KSD ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL : : : :: .:: .. :. . .:.::: NP_114 DCTFLTTENKEILSLEDKVVDFREKDSSSNLSYQSHDCSGACLMKM-PL---NLKGENPL 110 120 130 140 150 160 610 620 630 640 650 660 pF1KSD LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL .:. :.: :. ... ..:: :::::: ::...:. :::.:: :.::: . : . NP_114 QLPIKCHFQRRHAKTN-SHSSALHVSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSF 170 180 190 200 210 220 670 680 690 700 710 720 pF1KSD DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN . :: . :.. : .::. : :.::.: ::::. :: : : : . : NP_114 NTYVQLARNYPKQKEVVSDVDISNGVESVPISFCNEIDSRKLPQFKYRKTVWPRAYNLTN 230 240 250 260 270 280 730 740 750 760 770 780 pF1KSD TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE . : .:::..:: : .:::: ::: . . .: .. . ..::.::::.. .:::.:: NP_114 FSSMFTDSCDCSEGCIDITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYE 290 300 310 320 330 340 790 800 810 820 830 840 pF1KSD CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD :. :::. ..: ::.:::: :::::.:::..::::.:::::: .:.:::::.:..:. NP_114 CSLLCKCNRQLCQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSR- 350 360 370 380 390 400 850 860 870 880 890 900 pF1KSD FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE :. : :: . . .... :.. . .. ::. NP_114 -ANTEKSYGIDENGRDENTMKNI--FSKKRKLEVACSD---------------------- 410 420 430 910 920 930 940 950 960 pF1KSD SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP :. : . :: ..:: . : NP_114 ----------CEVEVLPL-------------------GL------ETHPRTAKTEKCP-- 440 450 460 970 980 990 1000 1010 pF1KSD PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSS-FKTNEGGEGRAGGSRM : . :: : : .. .:: . : .:... :. : :..: NP_114 ---PKFSNNPKELTVETKYDNISRIQYHSV----IRDPESKTAIFQHN--------GKKM 470 480 490 500 1020 1030 1040 1050 1060 1070 pF1KSD EAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSK : .:. .. .:. .: . : ....: .. .:: :. NP_114 EF--VSSESVTPEDNDGFKPPR-EHLNSKTK-GAQKDSSSNH------------------ 510 520 530 540 1080 1090 1100 1110 1120 1130 pF1KSD TSMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSG .. .. :. : ::. ... : :. : . ..::..:...:. NP_114 VDEFEDNLLIES------DVIDITKYRE---ET----PPRSRCNQATTLDNQNIK----- 550 560 570 580 1140 1150 1160 1170 1180 1190 pF1KSD SEGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQ .. . . .: . : :..: . . : . .. : :. :. . . NP_114 -KAIEVQIQKPQEG---RSTACQRQQVFC----------DEELLSETKNTSSD---SLTK 590 600 610 620 1200 1210 1220 1230 1240 1250 pF1KSD FYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGT : : . ...:: :::.::.::::: :::.::::::.::. :: ::::... ..: : NP_114 FNKG--NVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKART 630 640 650 660 670 680 1260 1270 1280 1290 pF1KSD ELTWDYNYEVGSVEGKELLCCCGAIECRGRLL ::::::.::.:.: ::..: ::. .:: ..: NP_114 ELTWDYGYEAGTVPEKEIFCQCGVNKCRKKIL 690 700 710 1291 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 23:45:58 2016 done: Wed Nov 2 23:46:00 2016 Total Scan time: 16.390 Total Display time: 0.370 Function used was FASTA [36.3.4 Apr, 2011]