FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0091, 1052 aa 1>>>pF1KSDA0091 1052 - 1052 aa - 1052 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5810+/-0.0004; mu= 15.0468+/- 0.025 mean_var=90.1353+/-18.392, 0's: 0 Z-trim(113.8): 14 B-trim: 1183 in 1/48 Lambda= 0.135091 statistics sampled from 23357 (23369) to 23357 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.64), E-opt: 0.2 (0.274), width: 16 Scan time: 11.000 The best scores are: opt bits E(85289) NP_003782 (OMIM: 603355) membrane-bound transcript (1052) 7205 1415.1 0 XP_016879305 (OMIM: 603355) PREDICTED: membrane-bo ( 611) 4243 837.8 0 XP_016879306 (OMIM: 603355) PREDICTED: membrane-bo ( 556) 3878 766.6 0 >>NP_003782 (OMIM: 603355) membrane-bound transcription (1052 aa) initn: 7205 init1: 7205 opt: 7205 Z-score: 7585.0 bits: 1415.1 E(85289): 0 Smith-Waterman score: 7205; 100.0% identity (100.0% similar) in 1052 aa overlap (1-1052:1-1052) 10 20 30 40 50 60 pF1KSD MKLVNIWLLLLVVLLCGKKHLGDRLEKKSFEKAPCPGCSHLTLKVEFSSTVVEYEYIVAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MKLVNIWLLLLVVLLCGKKHLGDRLEKKSFEKAPCPGCSHLTLKVEFSSTVVEYEYIVAF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NGYFTAKARNSFISSALKSSEVDNWRIIPRNNPSSDYPSDFEVIQIKEKQKAGLLTLEDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NGYFTAKARNSFISSALKSSEVDNWRIIPRNNPSSDYPSDFEVIQIKEKQKAGLLTLEDH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD PNIKRVTPQRKVFRSLKYAESDPTVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PNIKRVTPQRKVFRSLKYAESDPTVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGRH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD SSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHPHFKNVKERTNWTNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHPHFKNVKERTNWTNE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD RTLDDGLGHGTFVAGVIASMRECQGFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAILKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RTLDDGLGHGTFVAGVIASMRECQGFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAILKK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD IDVLNLSIGGPDFMDHPFVDKVWELTANNVIMVSAIGNDGPLYGTLNNPADQMDVIGVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 IDVLNLSIGGPDFMDHPFVDKVWELTANNVIMVSAIGNDGPLYGTLNNPADQMDVIGVGG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD IDFEDNIARFSSRGMTTWELPGGYGRMKPDIVTYGAGVRGSGVKGGCRALSGTSVASPVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 IDFEDNIARFSSRGMTTWELPGGYGRMKPDIVTYGAGVRGSGVKGGCRALSGTSVASPVV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD AGAVTLLVSTVQKRELVNPASMKQALIASARRLPGVNMFEQGHGKLDLLRAYQILNSYKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AGAVTLLVSTVQKRELVNPASMKQALIASARRLPGVNMFEQGHGKLDLLRAYQILNSYKP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD QASLSPSYIDLTECPYMWPYCSQPIYYGGMPTVVNVTILNGMGVTGRIVDKPDWQPYLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QASLSPSYIDLTECPYMWPYCSQPIYYGGMPTVVNVTILNGMGVTGRIVDKPDWQPYLPQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD NGDNIEVAFSYSSVLWPWSGYLAISISVTKKAASWEGIAQGHVMITVASPAETESKNGAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NGDNIEVAFSYSSVLWPWSGYLAISISVTKKAASWEGIAQGHVMITVASPAETESKNGAE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD QTSTVKLPIKVKIIPTPPRSKRVLWDQYHNLRYPPGYFPRDNLRMKNDPLDWNGDHIHTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QTSTVKLPIKVKIIPTPPRSKRVLWDQYHNLRYPPGYFPRDNLRMKNDPLDWNGDHIHTN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD FRDMYQHLRSMGYFVEVLGAPFTCFDASQYGTLLMVDSEEEYFPEEIAKLRRDVDNGLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 FRDMYQHLRSMGYFVEVLGAPFTCFDASQYGTLLMVDSEEEYFPEEIAKLRRDVDNGLSL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD VIFSDWYNTSVMRKVKFYDENTRQWWMPDTGGANIPALNELLSVWNMGFSDGLYEGEFTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VIFSDWYNTSVMRKVKFYDENTRQWWMPDTGGANIPALNELLSVWNMGFSDGLYEGEFTL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD ANHDMYYASGCSIAKFPEDGVVITQTFKDQGLEVLKQETAVVENVPILGLYQIPAEGGGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ANHDMYYASGCSIAKFPEDGVVITQTFKDQGLEVLKQETAVVENVPILGLYQIPAEGGGR 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD IVLYGDSNCLDDSHRQKDCFWLLDALLQYTSYGVTPPSLSHSGNRQRPPSGAGSVTPERM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 IVLYGDSNCLDDSHRQKDCFWLLDALLQYTSYGVTPPSLSHSGNRQRPPSGAGSVTPERM 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD EGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQPLNETAPSNLWKHQKLLSIDLDKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQPLNETAPSNLWKHQKLLSIDLDKV 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD VLPNFRSNRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQTIPVFAFLGAMVVLAFFVVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VLPNFRSNRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQTIPVFAFLGAMVVLAFFVVQ 970 980 990 1000 1010 1020 1030 1040 1050 pF1KSD INKAKSRPKRRKPRVKRPQLMQQVHPPKTPSV :::::::::::::::::::::::::::::::: NP_003 INKAKSRPKRRKPRVKRPQLMQQVHPPKTPSV 1030 1040 1050 >>XP_016879305 (OMIM: 603355) PREDICTED: membrane-bound (611 aa) initn: 4243 init1: 4243 opt: 4243 Z-score: 4468.9 bits: 837.8 E(85289): 0 Smith-Waterman score: 4243; 100.0% identity (100.0% similar) in 611 aa overlap (442-1052:1-611) 420 430 440 450 460 470 pF1KSD GTSVASPVVAGAVTLLVSTVQKRELVNPASMKQALIASARRLPGVNMFEQGHGKLDLLRA :::::::::::::::::::::::::::::: XP_016 MKQALIASARRLPGVNMFEQGHGKLDLLRA 10 20 30 480 490 500 510 520 530 pF1KSD YQILNSYKPQASLSPSYIDLTECPYMWPYCSQPIYYGGMPTVVNVTILNGMGVTGRIVDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YQILNSYKPQASLSPSYIDLTECPYMWPYCSQPIYYGGMPTVVNVTILNGMGVTGRIVDK 40 50 60 70 80 90 540 550 560 570 580 590 pF1KSD PDWQPYLPQNGDNIEVAFSYSSVLWPWSGYLAISISVTKKAASWEGIAQGHVMITVASPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDWQPYLPQNGDNIEVAFSYSSVLWPWSGYLAISISVTKKAASWEGIAQGHVMITVASPA 100 110 120 130 140 150 600 610 620 630 640 650 pF1KSD ETESKNGAEQTSTVKLPIKVKIIPTPPRSKRVLWDQYHNLRYPPGYFPRDNLRMKNDPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETESKNGAEQTSTVKLPIKVKIIPTPPRSKRVLWDQYHNLRYPPGYFPRDNLRMKNDPLD 160 170 180 190 200 210 660 670 680 690 700 710 pF1KSD WNGDHIHTNFRDMYQHLRSMGYFVEVLGAPFTCFDASQYGTLLMVDSEEEYFPEEIAKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WNGDHIHTNFRDMYQHLRSMGYFVEVLGAPFTCFDASQYGTLLMVDSEEEYFPEEIAKLR 220 230 240 250 260 270 720 730 740 750 760 770 pF1KSD RDVDNGLSLVIFSDWYNTSVMRKVKFYDENTRQWWMPDTGGANIPALNELLSVWNMGFSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDVDNGLSLVIFSDWYNTSVMRKVKFYDENTRQWWMPDTGGANIPALNELLSVWNMGFSD 280 290 300 310 320 330 780 790 800 810 820 830 pF1KSD GLYEGEFTLANHDMYYASGCSIAKFPEDGVVITQTFKDQGLEVLKQETAVVENVPILGLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLYEGEFTLANHDMYYASGCSIAKFPEDGVVITQTFKDQGLEVLKQETAVVENVPILGLY 340 350 360 370 380 390 840 850 860 870 880 890 pF1KSD QIPAEGGGRIVLYGDSNCLDDSHRQKDCFWLLDALLQYTSYGVTPPSLSHSGNRQRPPSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QIPAEGGGRIVLYGDSNCLDDSHRQKDCFWLLDALLQYTSYGVTPPSLSHSGNRQRPPSG 400 410 420 430 440 450 900 910 920 930 940 950 pF1KSD AGSVTPERMEGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQPLNETAPSNLWKHQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGSVTPERMEGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQPLNETAPSNLWKHQK 460 470 480 490 500 510 960 970 980 990 1000 1010 pF1KSD LLSIDLDKVVLPNFRSNRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQTIPVFAFLGAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLSIDLDKVVLPNFRSNRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQTIPVFAFLGAM 520 530 540 550 560 570 1020 1030 1040 1050 pF1KSD VVLAFFVVQINKAKSRPKRRKPRVKRPQLMQQVHPPKTPSV ::::::::::::::::::::::::::::::::::::::::: XP_016 VVLAFFVVQINKAKSRPKRRKPRVKRPQLMQQVHPPKTPSV 580 590 600 610 >>XP_016879306 (OMIM: 603355) PREDICTED: membrane-bound (556 aa) initn: 3878 init1: 3878 opt: 3878 Z-score: 4085.1 bits: 766.6 E(85289): 0 Smith-Waterman score: 3878; 100.0% identity (100.0% similar) in 556 aa overlap (497-1052:1-556) 470 480 490 500 510 520 pF1KSD DLLRAYQILNSYKPQASLSPSYIDLTECPYMWPYCSQPIYYGGMPTVVNVTILNGMGVTG :::::::::::::::::::::::::::::: XP_016 MWPYCSQPIYYGGMPTVVNVTILNGMGVTG 10 20 30 530 540 550 560 570 580 pF1KSD RIVDKPDWQPYLPQNGDNIEVAFSYSSVLWPWSGYLAISISVTKKAASWEGIAQGHVMIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RIVDKPDWQPYLPQNGDNIEVAFSYSSVLWPWSGYLAISISVTKKAASWEGIAQGHVMIT 40 50 60 70 80 90 590 600 610 620 630 640 pF1KSD VASPAETESKNGAEQTSTVKLPIKVKIIPTPPRSKRVLWDQYHNLRYPPGYFPRDNLRMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VASPAETESKNGAEQTSTVKLPIKVKIIPTPPRSKRVLWDQYHNLRYPPGYFPRDNLRMK 100 110 120 130 140 150 650 660 670 680 690 700 pF1KSD NDPLDWNGDHIHTNFRDMYQHLRSMGYFVEVLGAPFTCFDASQYGTLLMVDSEEEYFPEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NDPLDWNGDHIHTNFRDMYQHLRSMGYFVEVLGAPFTCFDASQYGTLLMVDSEEEYFPEE 160 170 180 190 200 210 710 720 730 740 750 760 pF1KSD IAKLRRDVDNGLSLVIFSDWYNTSVMRKVKFYDENTRQWWMPDTGGANIPALNELLSVWN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IAKLRRDVDNGLSLVIFSDWYNTSVMRKVKFYDENTRQWWMPDTGGANIPALNELLSVWN 220 230 240 250 260 270 770 780 790 800 810 820 pF1KSD MGFSDGLYEGEFTLANHDMYYASGCSIAKFPEDGVVITQTFKDQGLEVLKQETAVVENVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGFSDGLYEGEFTLANHDMYYASGCSIAKFPEDGVVITQTFKDQGLEVLKQETAVVENVP 280 290 300 310 320 330 830 840 850 860 870 880 pF1KSD ILGLYQIPAEGGGRIVLYGDSNCLDDSHRQKDCFWLLDALLQYTSYGVTPPSLSHSGNRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILGLYQIPAEGGGRIVLYGDSNCLDDSHRQKDCFWLLDALLQYTSYGVTPPSLSHSGNRQ 340 350 360 370 380 390 890 900 910 920 930 940 pF1KSD RPPSGAGSVTPERMEGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQPLNETAPSNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RPPSGAGSVTPERMEGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQPLNETAPSNL 400 410 420 430 440 450 950 960 970 980 990 1000 pF1KSD WKHQKLLSIDLDKVVLPNFRSNRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQTIPVFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WKHQKLLSIDLDKVVLPNFRSNRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQTIPVFA 460 470 480 490 500 510 1010 1020 1030 1040 1050 pF1KSD FLGAMVVLAFFVVQINKAKSRPKRRKPRVKRPQLMQQVHPPKTPSV :::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLGAMVVLAFFVVQINKAKSRPKRRKPRVKRPQLMQQVHPPKTPSV 520 530 540 550 1052 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 23:55:30 2016 done: Wed Nov 2 23:55:31 2016 Total Scan time: 11.000 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]