FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0120, 199 aa 1>>>pF1KSDA0120 199 - 199 aa - 199 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1380+/-0.000328; mu= 14.4621+/- 0.020 mean_var=69.4353+/-14.403, 0's: 0 Z-trim(115.1): 75 B-trim: 782 in 2/52 Lambda= 0.153916 statistics sampled from 25214 (25289) to 25214 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.69), E-opt: 0.2 (0.297), width: 16 Scan time: 5.740 The best scores are: opt bits E(85289) NP_001264152 (OMIM: 604634) transgelin-2 isoform b ( 199) 1356 309.7 2e-84 NP_003555 (OMIM: 604634) transgelin-2 isoform b [H ( 199) 1356 309.7 2e-84 NP_001264153 (OMIM: 604634) transgelin-2 isoform a ( 220) 1356 309.7 2.1e-84 NP_037391 (OMIM: 607953) transgelin-3 [Homo sapien ( 199) 1003 231.3 7.8e-61 NP_001008273 (OMIM: 607953) transgelin-3 [Homo sap ( 199) 1003 231.3 7.8e-61 NP_001008274 (OMIM: 607953) transgelin-3 [Homo sap ( 199) 1003 231.3 7.8e-61 NP_001001522 (OMIM: 600818) transgelin [Homo sapie ( 201) 919 212.7 3.2e-55 NP_003177 (OMIM: 600818) transgelin [Homo sapiens] ( 201) 919 212.7 3.2e-55 XP_016855734 (OMIM: 602374) PREDICTED: calponin-3 ( 288) 394 96.2 5.3e-20 NP_001272985 (OMIM: 602374) calponin-3 isoform 3 [ ( 288) 394 96.2 5.3e-20 NP_001830 (OMIM: 602374) calponin-3 isoform 1 [Hom ( 329) 394 96.3 5.9e-20 NP_004359 (OMIM: 602373) calponin-2 isoform a [Hom ( 309) 390 95.3 1e-19 NP_001290 (OMIM: 600806) calponin-1 isoform 1 [Hom ( 297) 385 94.2 2.2e-19 XP_016881778 (OMIM: 600806) PREDICTED: calponin-1 ( 363) 385 94.3 2.6e-19 XP_005259798 (OMIM: 600806) PREDICTED: calponin-1 ( 247) 371 91.1 1.6e-18 NP_001295271 (OMIM: 600806) calponin-1 isoform 2 [ ( 247) 371 91.1 1.6e-18 NP_001295270 (OMIM: 600806) calponin-1 isoform 2 [ ( 247) 371 91.1 1.6e-18 NP_958434 (OMIM: 602373) calponin-2 isoform b [Hom ( 270) 314 78.4 1.1e-14 NP_001290428 (OMIM: 602373) calponin-2 isoform c [ ( 298) 185 49.8 5.1e-06 NP_001290430 (OMIM: 602373) calponin-2 isoform d [ ( 330) 174 47.4 3e-05 NP_001272984 (OMIM: 602374) calponin-3 isoform 2 [ ( 283) 162 44.7 0.00017 >>NP_001264152 (OMIM: 604634) transgelin-2 isoform b [Ho (199 aa) initn: 1356 init1: 1356 opt: 1356 Z-score: 1636.8 bits: 309.7 E(85289): 2e-84 Smith-Waterman score: 1356; 100.0% identity (100.0% similar) in 199 aa overlap (1-199:1-199) 10 20 30 40 50 60 pF1KSD MANRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MANRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD VLCELINALYPEGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLCELINALYPEGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD NMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMGT 130 140 150 160 170 180 190 pF1KSD NRGASQAGMTGYGMPRQIL ::::::::::::::::::: NP_001 NRGASQAGMTGYGMPRQIL 190 >>NP_003555 (OMIM: 604634) transgelin-2 isoform b [Homo (199 aa) initn: 1356 init1: 1356 opt: 1356 Z-score: 1636.8 bits: 309.7 E(85289): 2e-84 Smith-Waterman score: 1356; 100.0% identity (100.0% similar) in 199 aa overlap (1-199:1-199) 10 20 30 40 50 60 pF1KSD MANRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MANRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD VLCELINALYPEGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VLCELINALYPEGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD NMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMGT 130 140 150 160 170 180 190 pF1KSD NRGASQAGMTGYGMPRQIL ::::::::::::::::::: NP_003 NRGASQAGMTGYGMPRQIL 190 >>NP_001264153 (OMIM: 604634) transgelin-2 isoform a [Ho (220 aa) initn: 1356 init1: 1356 opt: 1356 Z-score: 1636.2 bits: 309.7 E(85289): 2.1e-84 Smith-Waterman score: 1356; 100.0% identity (100.0% similar) in 199 aa overlap (1-199:22-220) 10 20 30 pF1KSD MANRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCR ::::::::::::::::::::::::::::::::::::::: NP_001 MSAFSLALALVSSPQPPPPIGMANRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCR 10 20 30 40 50 60 40 50 60 70 80 90 pF1KSD KDVGRPQPGRENFQNWLKDGTVLCELINALYPEGQAPVKKIQASTMAFKQMEQISQFLQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDVGRPQPGRENFQNWLKDGTVLCELINALYPEGQAPVKKIQASTMAFKQMEQISQFLQA 70 80 90 100 110 120 100 110 120 130 140 150 pF1KSD AERYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AERYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENP 130 140 150 160 170 180 160 170 180 190 pF1KSD RNFSDNQLQEGKNVIGLQMGTNRGASQAGMTGYGMPRQIL :::::::::::::::::::::::::::::::::::::::: NP_001 RNFSDNQLQEGKNVIGLQMGTNRGASQAGMTGYGMPRQIL 190 200 210 220 >>NP_037391 (OMIM: 607953) transgelin-3 [Homo sapiens] (199 aa) initn: 1019 init1: 1003 opt: 1003 Z-score: 1213.2 bits: 231.3 E(85289): 7.8e-61 Smith-Waterman score: 1003; 69.8% identity (89.4% similar) in 199 aa overlap (1-199:1-199) 10 20 30 40 50 60 pF1KSD MANRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGT ::::::.::::::::.:::..::::::. :..:: :: .:. .: ::: .::.:: ::: NP_037 MANRGPSYGLSREVQEKIEQKYDADLENKLVDWIILQCAEDIEHPPPGRAHFQKWLMDGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD VLCELINALYPEGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGK :::.:::.::: :: :. ::. : :::::::::::::.::: ::. :::::::::::::: NP_037 VLCKLINSLYPPGQEPIPKISESKMAFKQMEQISQFLKAAETYGVRTTDIFQTVDLWEGK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD NMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMGT .:: :::::: ::..::..::: . :.:.:: .:...: :.::..::..:.::::::::. NP_037 DMAAVQRTLMALGSVAVTKDDGCYRGEPSWFHRKAQQNRRGFSEEQLRQGQNVIGLQMGS 130 140 150 160 170 180 190 pF1KSD NRGASQAGMTGYGMPRQIL :.::::::::::::::::. NP_037 NKGASQAGMTGYGMPRQIM 190 >>NP_001008273 (OMIM: 607953) transgelin-3 [Homo sapiens (199 aa) initn: 1019 init1: 1003 opt: 1003 Z-score: 1213.2 bits: 231.3 E(85289): 7.8e-61 Smith-Waterman score: 1003; 69.8% identity (89.4% similar) in 199 aa overlap (1-199:1-199) 10 20 30 40 50 60 pF1KSD MANRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGT ::::::.::::::::.:::..::::::. :..:: :: .:. .: ::: .::.:: ::: NP_001 MANRGPSYGLSREVQEKIEQKYDADLENKLVDWIILQCAEDIEHPPPGRAHFQKWLMDGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD VLCELINALYPEGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGK :::.:::.::: :: :. ::. : :::::::::::::.::: ::. :::::::::::::: NP_001 VLCKLINSLYPPGQEPIPKISESKMAFKQMEQISQFLKAAETYGVRTTDIFQTVDLWEGK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD NMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMGT .:: :::::: ::..::..::: . :.:.:: .:...: :.::..::..:.::::::::. NP_001 DMAAVQRTLMALGSVAVTKDDGCYRGEPSWFHRKAQQNRRGFSEEQLRQGQNVIGLQMGS 130 140 150 160 170 180 190 pF1KSD NRGASQAGMTGYGMPRQIL :.::::::::::::::::. NP_001 NKGASQAGMTGYGMPRQIM 190 >>NP_001008274 (OMIM: 607953) transgelin-3 [Homo sapiens (199 aa) initn: 1019 init1: 1003 opt: 1003 Z-score: 1213.2 bits: 231.3 E(85289): 7.8e-61 Smith-Waterman score: 1003; 69.8% identity (89.4% similar) in 199 aa overlap (1-199:1-199) 10 20 30 40 50 60 pF1KSD MANRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGT ::::::.::::::::.:::..::::::. :..:: :: .:. .: ::: .::.:: ::: NP_001 MANRGPSYGLSREVQEKIEQKYDADLENKLVDWIILQCAEDIEHPPPGRAHFQKWLMDGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD VLCELINALYPEGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGK :::.:::.::: :: :. ::. : :::::::::::::.::: ::. :::::::::::::: NP_001 VLCKLINSLYPPGQEPIPKISESKMAFKQMEQISQFLKAAETYGVRTTDIFQTVDLWEGK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD NMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMGT .:: :::::: ::..::..::: . :.:.:: .:...: :.::..::..:.::::::::. NP_001 DMAAVQRTLMALGSVAVTKDDGCYRGEPSWFHRKAQQNRRGFSEEQLRQGQNVIGLQMGS 130 140 150 160 170 180 190 pF1KSD NRGASQAGMTGYGMPRQIL :.::::::::::::::::. NP_001 NKGASQAGMTGYGMPRQIM 190 >>NP_001001522 (OMIM: 600818) transgelin [Homo sapiens] (201 aa) initn: 930 init1: 567 opt: 919 Z-score: 1112.3 bits: 212.7 E(85289): 3.2e-55 Smith-Waterman score: 919; 65.0% identity (87.5% similar) in 200 aa overlap (1-199:1-200) 10 20 30 40 50 60 pF1KSD MANRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGT :::.::.::.:::::.::::.:: .::. :..:: .:: :::::. :: .:: :::.:. NP_001 MANKGPSYGMSREVQSKIEKKYDEELEERLVEWIIVQCGPDVGRPDRGRLGFQVWLKNGV 10 20 30 40 50 60 70 80 90 100 110 pF1KSD VLCELINALYPEGQAPVKKIQAS-TMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEG .: .:.:.:::.:. ::: . .:.::::::..:::.::: ::. ::.::::::.:: NP_001 ILSKLVNSLYPDGSKPVKVPENPPSMVFKQMEQVAQFLKAAEDYGVIKTDMFQTVDLFEG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KSD KNMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMG :.:: :::::: ::.:::...:: . :::::: ::..:. :.:...::::::.::::::: NP_001 KDMAAVQRTLMALGSLAVTKNDGHYRGDPNWFMKKAQEHKREFTESQLQEGKHVIGLQMG 130 140 150 160 170 180 180 190 pF1KSD TNRGASQAGMTGYGMPRQIL .::::::::::::: ::::. NP_001 SNRGASQAGMTGYGRPRQIIS 190 200 >>NP_003177 (OMIM: 600818) transgelin [Homo sapiens] (201 aa) initn: 930 init1: 567 opt: 919 Z-score: 1112.3 bits: 212.7 E(85289): 3.2e-55 Smith-Waterman score: 919; 65.0% identity (87.5% similar) in 200 aa overlap (1-199:1-200) 10 20 30 40 50 60 pF1KSD MANRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGT :::.::.::.:::::.::::.:: .::. :..:: .:: :::::. :: .:: :::.:. NP_003 MANKGPSYGMSREVQSKIEKKYDEELEERLVEWIIVQCGPDVGRPDRGRLGFQVWLKNGV 10 20 30 40 50 60 70 80 90 100 110 pF1KSD VLCELINALYPEGQAPVKKIQAS-TMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEG .: .:.:.:::.:. ::: . .:.::::::..:::.::: ::. ::.::::::.:: NP_003 ILSKLVNSLYPDGSKPVKVPENPPSMVFKQMEQVAQFLKAAEDYGVIKTDMFQTVDLFEG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KSD KNMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMG :.:: :::::: ::.:::...:: . :::::: ::..:. :.:...::::::.::::::: NP_003 KDMAAVQRTLMALGSLAVTKNDGHYRGDPNWFMKKAQEHKREFTESQLQEGKHVIGLQMG 130 140 150 160 170 180 180 190 pF1KSD TNRGASQAGMTGYGMPRQIL .::::::::::::: ::::. NP_003 SNRGASQAGMTGYGRPRQIIS 190 200 >>XP_016855734 (OMIM: 602374) PREDICTED: calponin-3 isof (288 aa) initn: 539 init1: 174 opt: 394 Z-score: 480.0 bits: 96.2 E(85289): 5.3e-20 Smith-Waterman score: 394; 45.9% identity (73.0% similar) in 148 aa overlap (51-198:6-147) 30 40 50 60 70 80 pF1KSD QYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGTVLCELINALYPEGQAPVKKI ::: :::: .:::::: : : . :::. XP_016 MSIGPNFQLGLKDGIILCELINKLQP---GSVKKV 10 20 30 90 100 110 120 130 140 pF1KSD QASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARD . :.. . :.:.:..:..: . ::.. :::.. ::.:. ::. :: ::. :.:: :. XP_016 NESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVALAGL--AKT 40 50 60 70 80 90 150 160 170 180 190 pF1KSD DGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMGTNRGASQAGMTGYGMPRQIL : : . : .... : :....:. :..:::::::::. :::::::.:: :.. XP_016 KG-FHTTIDIGVKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMTAYGTRRHLYD 100 110 120 130 140 XP_016 PKMQTDKPFDQTTISLQMGTNKGASQAGMLAPGTRRDIYDQKLTLQPVDNSTISLQMGTN 150 160 170 180 190 200 >>NP_001272985 (OMIM: 602374) calponin-3 isoform 3 [Homo (288 aa) initn: 539 init1: 174 opt: 394 Z-score: 480.0 bits: 96.2 E(85289): 5.3e-20 Smith-Waterman score: 394; 45.9% identity (73.0% similar) in 148 aa overlap (51-198:6-147) 30 40 50 60 70 80 pF1KSD QYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGTVLCELINALYPEGQAPVKKI ::: :::: .:::::: : : . :::. NP_001 MSIGPNFQLGLKDGIILCELINKLQP---GSVKKV 10 20 30 90 100 110 120 130 140 pF1KSD QASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARD . :.. . :.:.:..:..: . ::.. :::.. ::.:. ::. :: ::. :.:: :. NP_001 NESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVALAGL--AKT 40 50 60 70 80 90 150 160 170 180 190 pF1KSD DGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMGTNRGASQAGMTGYGMPRQIL : : . : .... : :....:. :..:::::::::. :::::::.:: :.. NP_001 KG-FHTTIDIGVKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMTAYGTRRHLYD 100 110 120 130 140 NP_001 PKMQTDKPFDQTTISLQMGTNKGASQAGMLAPGTRRDIYDQKLTLQPVDNSTISLQMGTN 150 160 170 180 190 200 199 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 00:05:34 2016 done: Thu Nov 3 00:05:35 2016 Total Scan time: 5.740 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]