Result of FASTA (omim) for
pF1KSDA0132
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0132, 624 aa
1>>>pF1KSDA0132 624 - 624 aa - 624 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5654+/-0.000429; mu= 17.7707+/- 0.026
mean_var=79.8382+/-17.332, 0's: 0 Z-trim(109.9): 338 B-trim: 1707 in 2/53
Lambda= 0.143539
statistics sampled from 17750 (18150) to 17750 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.571), E-opt: 0.2 (0.213), width: 16
Scan time: 10.000
The best scores are: opt bits E(85289)
NP_987096 (OMIM: 606016) kelch-like ECH-associated ( 624) 4314 903.9 0
NP_036421 (OMIM: 606016) kelch-like ECH-associated ( 624) 4314 903.9 0
XP_005260231 (OMIM: 606016) PREDICTED: kelch-like ( 624) 4314 903.9 0
XP_005260230 (OMIM: 606016) PREDICTED: kelch-like ( 624) 4314 903.9 0
XP_011526754 (OMIM: 606016) PREDICTED: kelch-like ( 624) 4314 903.9 0
NP_001165125 (OMIM: 608064) kelch-like protein 5 i ( 568) 1262 271.8 4.4e-72
NP_001007076 (OMIM: 608064) kelch-like protein 5 i ( 709) 1262 271.9 5.3e-72
NP_057074 (OMIM: 608064) kelch-like protein 5 isof ( 755) 1262 271.9 5.6e-72
XP_016863764 (OMIM: 608064) PREDICTED: kelch-like ( 788) 1262 271.9 5.7e-72
XP_005262712 (OMIM: 608064) PREDICTED: kelch-like ( 789) 1262 271.9 5.8e-72
NP_009177 (OMIM: 605774) kelch-like protein 2 isof ( 593) 1248 269.0 3.4e-71
NP_001154993 (OMIM: 605774) kelch-like protein 2 i ( 597) 1248 269.0 3.4e-71
NP_067646 (OMIM: 614522) kelch-like protein 12 iso ( 568) 1247 268.7 3.8e-71
NP_001289980 (OMIM: 614522) kelch-like protein 12 ( 606) 1247 268.8 4e-71
XP_011508137 (OMIM: 614522) PREDICTED: kelch-like ( 623) 1247 268.8 4.1e-71
XP_016863163 (OMIM: 605774) PREDICTED: kelch-like ( 555) 1239 267.1 1.2e-70
XP_016863762 (OMIM: 608064) PREDICTED: kelch-like ( 804) 1241 267.6 1.2e-70
XP_011512001 (OMIM: 608064) PREDICTED: kelch-like ( 804) 1241 267.6 1.2e-70
XP_016863763 (OMIM: 608064) PREDICTED: kelch-like ( 804) 1241 267.6 1.2e-70
XP_011512003 (OMIM: 608064) PREDICTED: kelch-like ( 788) 1237 266.8 2.1e-70
XP_016863765 (OMIM: 608064) PREDICTED: kelch-like ( 788) 1237 266.8 2.1e-70
XP_011512002 (OMIM: 608064) PREDICTED: kelch-like ( 788) 1237 266.8 2.1e-70
NP_065917 (OMIM: 605332) kelch-like protein 1 isof ( 748) 1228 264.9 7.3e-70
XP_016876167 (OMIM: 605332) PREDICTED: kelch-like ( 575) 1222 263.6 1.4e-69
NP_059111 (OMIM: 605775,614495) kelch-like protein ( 587) 1204 259.8 1.9e-68
NP_950240 (OMIM: 608064) kelch-like protein 5 isof ( 694) 1201 259.3 3.3e-68
NP_001244123 (OMIM: 605775,614495) kelch-like prot ( 555) 1193 257.6 8.7e-68
XP_011529874 (OMIM: 605774) PREDICTED: kelch-like ( 633) 1189 256.8 1.7e-67
NP_061990 (OMIM: 300348) kelch-like protein 4 isof ( 718) 1188 256.6 2.2e-67
NP_001273654 (OMIM: 605332) kelch-like protein 1 i ( 687) 1162 251.2 8.8e-66
NP_476503 (OMIM: 300348) kelch-like protein 4 isof ( 720) 1160 250.8 1.2e-65
XP_016876168 (OMIM: 605332) PREDICTED: kelch-like ( 525) 1158 250.3 1.3e-65
NP_065854 (OMIM: 611967) kelch-like protein 8 isof ( 620) 1047 227.4 1.2e-58
NP_001278932 (OMIM: 611967) kelch-like protein 8 i ( 620) 1047 227.4 1.2e-58
NP_001026880 (OMIM: 611119,612943,617055) kelch-li ( 586) 945 206.2 2.6e-52
XP_016867928 (OMIM: 611119,612943,617055) PREDICTE ( 564) 920 201.0 9.2e-51
XP_016857484 (OMIM: 614522) PREDICTED: kelch-like ( 471) 906 198.1 5.9e-50
XP_011508138 (OMIM: 614522) PREDICTED: kelch-like ( 526) 906 198.1 6.5e-50
NP_001278935 (OMIM: 611967) kelch-like protein 8 i ( 544) 898 196.5 2.1e-49
NP_061334 (OMIM: 611119,612943,617055) kelch-like ( 538) 882 193.1 2.1e-48
XP_016863164 (OMIM: 605774) PREDICTED: kelch-like ( 415) 813 178.8 3.4e-44
XP_005247610 (OMIM: 611295) PREDICTED: kelch-like ( 600) 800 176.2 2.9e-43
XP_016862149 (OMIM: 611295) PREDICTED: kelch-like ( 600) 800 176.2 2.9e-43
XP_005247613 (OMIM: 611295) PREDICTED: kelch-like ( 600) 800 176.2 2.9e-43
XP_016862148 (OMIM: 611295) PREDICTED: kelch-like ( 600) 800 176.2 2.9e-43
XP_011511240 (OMIM: 611295) PREDICTED: kelch-like ( 600) 800 176.2 2.9e-43
XP_005247612 (OMIM: 611295) PREDICTED: kelch-like ( 600) 800 176.2 2.9e-43
XP_005247611 (OMIM: 611295) PREDICTED: kelch-like ( 600) 800 176.2 2.9e-43
NP_060114 (OMIM: 611295) kelch-like protein 24 [Ho ( 600) 800 176.2 2.9e-43
XP_005247609 (OMIM: 611295) PREDICTED: kelch-like ( 600) 800 176.2 2.9e-43
>>NP_987096 (OMIM: 606016) kelch-like ECH-associated pro (624 aa)
initn: 4314 init1: 4314 opt: 4314 Z-score: 4830.2 bits: 903.9 E(85289): 0
Smith-Waterman score: 4314; 100.0% identity (100.0% similar) in 624 aa overlap (1-624:1-624)
10 20 30 40 50 60
pF1KSD MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_987 MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_987 KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_987 EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_987 PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_987 CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_987 LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_987 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_987 IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_987 TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_987 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
550 560 570 580 590 600
610 620
pF1KSD RSGVGVAVTMEPCRKQIDQQNCTC
::::::::::::::::::::::::
NP_987 RSGVGVAVTMEPCRKQIDQQNCTC
610 620
>>NP_036421 (OMIM: 606016) kelch-like ECH-associated pro (624 aa)
initn: 4314 init1: 4314 opt: 4314 Z-score: 4830.2 bits: 903.9 E(85289): 0
Smith-Waterman score: 4314; 100.0% identity (100.0% similar) in 624 aa overlap (1-624:1-624)
10 20 30 40 50 60
pF1KSD MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
550 560 570 580 590 600
610 620
pF1KSD RSGVGVAVTMEPCRKQIDQQNCTC
::::::::::::::::::::::::
NP_036 RSGVGVAVTMEPCRKQIDQQNCTC
610 620
>>XP_005260231 (OMIM: 606016) PREDICTED: kelch-like ECH- (624 aa)
initn: 4314 init1: 4314 opt: 4314 Z-score: 4830.2 bits: 903.9 E(85289): 0
Smith-Waterman score: 4314; 100.0% identity (100.0% similar) in 624 aa overlap (1-624:1-624)
10 20 30 40 50 60
pF1KSD MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
550 560 570 580 590 600
610 620
pF1KSD RSGVGVAVTMEPCRKQIDQQNCTC
::::::::::::::::::::::::
XP_005 RSGVGVAVTMEPCRKQIDQQNCTC
610 620
>>XP_005260230 (OMIM: 606016) PREDICTED: kelch-like ECH- (624 aa)
initn: 4314 init1: 4314 opt: 4314 Z-score: 4830.2 bits: 903.9 E(85289): 0
Smith-Waterman score: 4314; 100.0% identity (100.0% similar) in 624 aa overlap (1-624:1-624)
10 20 30 40 50 60
pF1KSD MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
550 560 570 580 590 600
610 620
pF1KSD RSGVGVAVTMEPCRKQIDQQNCTC
::::::::::::::::::::::::
XP_005 RSGVGVAVTMEPCRKQIDQQNCTC
610 620
>>XP_011526754 (OMIM: 606016) PREDICTED: kelch-like ECH- (624 aa)
initn: 4314 init1: 4314 opt: 4314 Z-score: 4830.2 bits: 903.9 E(85289): 0
Smith-Waterman score: 4314; 100.0% identity (100.0% similar) in 624 aa overlap (1-624:1-624)
10 20 30 40 50 60
pF1KSD MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
550 560 570 580 590 600
610 620
pF1KSD RSGVGVAVTMEPCRKQIDQQNCTC
::::::::::::::::::::::::
XP_011 RSGVGVAVTMEPCRKQIDQQNCTC
610 620
>>NP_001165125 (OMIM: 608064) kelch-like protein 5 isofo (568 aa)
initn: 1539 init1: 820 opt: 1262 Z-score: 1415.1 bits: 271.8 E(85289): 4.4e-72
Smith-Waterman score: 1262; 37.0% identity (67.1% similar) in 560 aa overlap (58-606:14-563)
30 40 50 60 70 80
pF1KSD GDAVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQD
.:..:.: :.. .::::: : . .
NP_001 MEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRR
10 20 30 40
90 100 110 120 130 140
pF1KSD APAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISM
:: :..::.: : : ::::: .:: .: ...::..:. . ::..:::. . .
NP_001 IPA-----HRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLEL
50 60 70 80 90
150 160 170 180 190 200
pF1KSD GEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYI
: . ... : . :...::.:: ::..:: ::: .:: .::. ::..::. :..:
NP_001 KEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYT
100 110 120 130 140 150
210 220 230 240 250 260
pF1KSD YMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQAL
. :: :: ...:: : ... :.. ::.:. : ...: ..::..: :::: .. :
NP_001 MEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKL
160 170 180 190 200 210
270 280 290 300 310 320
pF1KSD LRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKI--FEELTLHKPTQVMPCRAPK--
: .: :.:.:: .... ....: .:. ... .. : ..: : :.
NP_001 LAYIRLPLLAPQFLA-DMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKS
220 230 240 250 260 270
330 340 350 360 370 380
pF1KSD -VGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNN
:: :. ..: .. . .: :. . : .:... : .. :. ::.::::
NP_001 TVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR--
280 290 300 310 320 330
390 400 410 420 430 440
pF1KSD SPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVER
:: ....:::: :. :: :::. :. .::.:..: .::::: : . :.:::
NP_001 --DGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVER
340 350 360 370 380 390
450 460 470 480 490 500
pF1KSD YEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITA
..:. .:..:: : : : ::::::. :::::: ::.. :.:.::. :. :.: . .
NP_001 WDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQ
400 410 420 430 440 450
510 520 530 540 550
pF1KSD MNTIRSGAGVCVLHNCIYAAGGYDGQ-DQLNS-----VERYDVETETWTFVAPMKHRRSA
:. :.:.:: . .. .:: ::.:. ..:.: ::::: .:. :: :: :. :.:
NP_001 MSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDA
460 470 480 490 500 510
560 570 580 590 600 610
pF1KSD LGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQ
.:. . ..:..:::::...:..:: :::.:. :..:. . ::.:. :
NP_001 VGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL
520 530 540 550 560
620
pF1KSD IDQQNCTC
>>NP_001007076 (OMIM: 608064) kelch-like protein 5 isofo (709 aa)
initn: 1539 init1: 820 opt: 1262 Z-score: 1413.7 bits: 271.9 E(85289): 5.3e-72
Smith-Waterman score: 1262; 37.0% identity (67.1% similar) in 560 aa overlap (58-606:155-704)
30 40 50 60 70 80
pF1KSD GDAVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQD
.:..:.: :.. .::::: : . .
NP_001 SSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRR
130 140 150 160 170 180
90 100 110 120 130 140
pF1KSD APAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISM
:: :..::.: : : ::::: .:: .: ...::..:. . ::..:::. . .
NP_001 IPA-----HRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLEL
190 200 210 220 230
150 160 170 180 190 200
pF1KSD GEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYI
: . ... : . :...::.:: ::..:: ::: .:: .::. ::..::. :..:
NP_001 KEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYT
240 250 260 270 280 290
210 220 230 240 250 260
pF1KSD YMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQAL
. :: :: ...:: : ... :.. ::.:. : ...: ..::..: :::: .. :
NP_001 MEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKL
300 310 320 330 340 350
270 280 290 300 310 320
pF1KSD LRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKI--FEELTLHKPTQVMPCRAPK--
: .: :.:.:: .... ....: .:. ... .. : ..: : :.
NP_001 LAYIRLPLLAPQFLA-DMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKS
360 370 380 390 400 410
330 340 350 360 370 380
pF1KSD -VGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNN
:: :. ..: .. . .: :. . : .:... : .. :. ::.::::
NP_001 TVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR--
420 430 440 450 460 470
390 400 410 420 430 440
pF1KSD SPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVER
:: ....:::: :. :: :::. :. .::.:..: .::::: : . :.:::
NP_001 --DGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVER
480 490 500 510 520 530
450 460 470 480 490 500
pF1KSD YEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITA
..:. .:..:: : : : ::::::. :::::: ::.. :.:.::. :. :.: . .
NP_001 WDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQ
540 550 560 570 580 590
510 520 530 540 550
pF1KSD MNTIRSGAGVCVLHNCIYAAGGYDGQ-DQLNS-----VERYDVETETWTFVAPMKHRRSA
:. :.:.:: . .. .:: ::.:. ..:.: ::::: .:. :: :: :. :.:
NP_001 MSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDA
600 610 620 630 640 650
560 570 580 590 600 610
pF1KSD LGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQ
.:. . ..:..:::::...:..:: :::.:. :..:. . ::.:. :
NP_001 VGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL
660 670 680 690 700
620
pF1KSD IDQQNCTC
>>NP_057074 (OMIM: 608064) kelch-like protein 5 isoform (755 aa)
initn: 1539 init1: 820 opt: 1262 Z-score: 1413.3 bits: 271.9 E(85289): 5.6e-72
Smith-Waterman score: 1262; 37.0% identity (67.1% similar) in 560 aa overlap (58-606:201-750)
30 40 50 60 70 80
pF1KSD GDAVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQD
.:..:.: :.. .::::: : . .
NP_057 SSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRR
180 190 200 210 220 230
90 100 110 120 130 140
pF1KSD APAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISM
:: :..::.: : : ::::: .:: .: ...::..:. . ::..:::. . .
NP_057 IPA-----HRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLEL
240 250 260 270 280
150 160 170 180 190 200
pF1KSD GEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYI
: . ... : . :...::.:: ::..:: ::: .:: .::. ::..::. :..:
NP_057 KEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYT
290 300 310 320 330 340
210 220 230 240 250 260
pF1KSD YMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQAL
. :: :: ...:: : ... :.. ::.:. : ...: ..::..: :::: .. :
NP_057 MEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKL
350 360 370 380 390 400
270 280 290 300 310 320
pF1KSD LRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKI--FEELTLHKPTQVMPCRAPK--
: .: :.:.:: .... ....: .:. ... .. : ..: : :.
NP_057 LAYIRLPLLAPQFLA-DMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKS
410 420 430 440 450 460
330 340 350 360 370 380
pF1KSD -VGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNN
:: :. ..: .. . .: :. . : .:... : .. :. ::.::::
NP_057 TVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR--
470 480 490 500 510 520
390 400 410 420 430 440
pF1KSD SPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVER
:: ....:::: :. :: :::. :. .::.:..: .::::: : . :.:::
NP_057 --DGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVER
530 540 550 560 570 580
450 460 470 480 490 500
pF1KSD YEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITA
..:. .:..:: : : : ::::::. :::::: ::.. :.:.::. :. :.: . .
NP_057 WDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQ
590 600 610 620 630 640
510 520 530 540 550
pF1KSD MNTIRSGAGVCVLHNCIYAAGGYDGQ-DQLNS-----VERYDVETETWTFVAPMKHRRSA
:. :.:.:: . .. .:: ::.:. ..:.: ::::: .:. :: :: :. :.:
NP_057 MSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDA
650 660 670 680 690 700
560 570 580 590 600 610
pF1KSD LGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQ
.:. . ..:..:::::...:..:: :::.:. :..:. . ::.:. :
NP_057 VGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL
710 720 730 740 750
620
pF1KSD IDQQNCTC
>>XP_016863764 (OMIM: 608064) PREDICTED: kelch-like prot (788 aa)
initn: 1539 init1: 820 opt: 1262 Z-score: 1413.0 bits: 271.9 E(85289): 5.7e-72
Smith-Waterman score: 1262; 37.0% identity (67.1% similar) in 560 aa overlap (58-606:234-783)
30 40 50 60 70 80
pF1KSD GDAVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQD
.:..:.: :.. .::::: : . .
XP_016 SSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRR
210 220 230 240 250 260
90 100 110 120 130 140
pF1KSD APAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISM
:: :..::.: : : ::::: .:: .: ...::..:. . ::..:::. . .
XP_016 IPA-----HRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLEL
270 280 290 300 310
150 160 170 180 190 200
pF1KSD GEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYI
: . ... : . :...::.:: ::..:: ::: .:: .::. ::..::. :..:
XP_016 KEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYT
320 330 340 350 360 370
210 220 230 240 250 260
pF1KSD YMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQAL
. :: :: ...:: : ... :.. ::.:. : ...: ..::..: :::: .. :
XP_016 MEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKL
380 390 400 410 420 430
270 280 290 300 310 320
pF1KSD LRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKI--FEELTLHKPTQVMPCRAPK--
: .: :.:.:: .... ....: .:. ... .. : ..: : :.
XP_016 LAYIRLPLLAPQFLA-DMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKS
440 450 460 470 480 490
330 340 350 360 370 380
pF1KSD -VGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNN
:: :. ..: .. . .: :. . : .:... : .. :. ::.::::
XP_016 TVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR--
500 510 520 530 540 550
390 400 410 420 430 440
pF1KSD SPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVER
:: ....:::: :. :: :::. :. .::.:..: .::::: : . :.:::
XP_016 --DGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVER
560 570 580 590 600 610
450 460 470 480 490 500
pF1KSD YEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITA
..:. .:..:: : : : ::::::. :::::: ::.. :.:.::. :. :.: . .
XP_016 WDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQ
620 630 640 650 660 670
510 520 530 540 550
pF1KSD MNTIRSGAGVCVLHNCIYAAGGYDGQ-DQLNS-----VERYDVETETWTFVAPMKHRRSA
:. :.:.:: . .. .:: ::.:. ..:.: ::::: .:. :: :: :. :.:
XP_016 MSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDA
680 690 700 710 720 730
560 570 580 590 600 610
pF1KSD LGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQ
.:. . ..:..:::::...:..:: :::.:. :..:. . ::.:. :
XP_016 VGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL
740 750 760 770 780
620
pF1KSD IDQQNCTC
>>XP_005262712 (OMIM: 608064) PREDICTED: kelch-like prot (789 aa)
initn: 1539 init1: 820 opt: 1262 Z-score: 1413.0 bits: 271.9 E(85289): 5.8e-72
Smith-Waterman score: 1262; 37.0% identity (67.1% similar) in 560 aa overlap (58-606:235-784)
30 40 50 60 70 80
pF1KSD GDAVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQD
.:..:.: :.. .::::: : . .
XP_005 SSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRR
210 220 230 240 250 260
90 100 110 120 130 140
pF1KSD APAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISM
:: :..::.: : : ::::: .:: .: ...::..:. . ::..:::. . .
XP_005 IPA-----HRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLEL
270 280 290 300 310
150 160 170 180 190 200
pF1KSD GEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYI
: . ... : . :...::.:: ::..:: ::: .:: .::. ::..::. :..:
XP_005 KEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYT
320 330 340 350 360 370
210 220 230 240 250 260
pF1KSD YMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQAL
. :: :: ...:: : ... :.. ::.:. : ...: ..::..: :::: .. :
XP_005 MEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKL
380 390 400 410 420 430
270 280 290 300 310 320
pF1KSD LRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKI--FEELTLHKPTQVMPCRAPK--
: .: :.:.:: .... ....: .:. ... .. : ..: : :.
XP_005 LAYIRLPLLAPQFLA-DMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKS
440 450 460 470 480 490
330 340 350 360 370 380
pF1KSD -VGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNN
:: :. ..: .. . .: :. . : .:... : .. :. ::.::::
XP_005 TVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR--
500 510 520 530 540 550
390 400 410 420 430 440
pF1KSD SPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVER
:: ....:::: :. :: :::. :. .::.:..: .::::: : . :.:::
XP_005 --DGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVER
560 570 580 590 600 610
450 460 470 480 490 500
pF1KSD YEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITA
..:. .:..:: : : : ::::::. :::::: ::.. :.:.::. :. :.: . .
XP_005 WDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQ
620 630 640 650 660 670
510 520 530 540 550
pF1KSD MNTIRSGAGVCVLHNCIYAAGGYDGQ-DQLNS-----VERYDVETETWTFVAPMKHRRSA
:. :.:.:: . .. .:: ::.:. ..:.: ::::: .:. :: :: :. :.:
XP_005 MSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDA
680 690 700 710 720 730
560 570 580 590 600 610
pF1KSD LGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQ
.:. . ..:..:::::...:..:: :::.:. :..:. . ::.:. :
XP_005 VGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL
740 750 760 770 780
620
pF1KSD IDQQNCTC
624 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 00:08:55 2016 done: Thu Nov 3 00:08:56 2016
Total Scan time: 10.000 Total Display time: 0.180
Function used was FASTA [36.3.4 Apr, 2011]