FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0171, 625 aa 1>>>pF1KSDA0171 625 - 625 aa - 625 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.9317+/-0.000438; mu= -2.3627+/- 0.027 mean_var=225.3705+/-47.630, 0's: 0 Z-trim(117.9): 44 B-trim: 1113 in 2/52 Lambda= 0.085433 statistics sampled from 30322 (30366) to 30322 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.699), E-opt: 0.2 (0.356), width: 16 Scan time: 10.910 The best scores are: opt bits E(85289) NP_055481 (OMIM: 607265) clathrin interactor 1 iso ( 625) 4140 523.6 8.1e-148 XP_016865576 (OMIM: 607265) PREDICTED: clathrin in ( 518) 3365 428.0 3.9e-119 NP_001182484 (OMIM: 607265) clathrin interactor 1 ( 643) 3123 398.2 4.5e-110 XP_011533003 (OMIM: 607265) PREDICTED: clathrin in ( 536) 3073 392.0 2.8e-108 XP_016865577 (OMIM: 607265) PREDICTED: clathrin in ( 468) 3032 387.0 8.2e-107 NP_001182485 (OMIM: 607265) clathrin interactor 1 ( 625) 3007 383.9 8.9e-106 NP_001308192 (OMIM: 607262) epsin-1 isoform d [Hom ( 575) 630 90.9 1.3e-17 XP_011525182 (OMIM: 607262) PREDICTED: epsin-1 iso ( 575) 630 90.9 1.3e-17 NP_001123544 (OMIM: 607262) epsin-1 isoform b [Hom ( 576) 625 90.3 2e-17 XP_005258886 (OMIM: 607262) PREDICTED: epsin-1 iso ( 576) 625 90.3 2e-17 XP_016882213 (OMIM: 607262) PREDICTED: epsin-1 iso ( 636) 625 90.3 2.2e-17 XP_016882212 (OMIM: 607262) PREDICTED: epsin-1 iso ( 636) 625 90.3 2.2e-17 NP_060427 (OMIM: 607264) epsin-3 [Homo sapiens] ( 632) 616 89.2 4.6e-17 NP_683723 (OMIM: 607263) epsin-2 isoform a [Homo s ( 584) 611 88.6 6.6e-17 XP_016882211 (OMIM: 607262) PREDICTED: epsin-1 iso ( 550) 572 83.8 1.8e-15 NP_037465 (OMIM: 607262) epsin-1 isoform c [Homo s ( 550) 572 83.8 1.8e-15 XP_011525183 (OMIM: 607262) PREDICTED: epsin-1 iso ( 551) 559 82.2 5.4e-15 XP_016882214 (OMIM: 607262) PREDICTED: epsin-1 iso ( 611) 559 82.2 5.9e-15 NP_001123543 (OMIM: 607262) epsin-1 isoform a [Hom ( 662) 559 82.2 6.3e-15 NP_055779 (OMIM: 607263) epsin-2 isoform b [Homo s ( 641) 557 82.0 7.2e-15 >>NP_055481 (OMIM: 607265) clathrin interactor 1 isoform (625 aa) initn: 4140 init1: 4140 opt: 4140 Z-score: 2774.8 bits: 523.6 E(85289): 8.1e-148 Smith-Waterman score: 4140; 100.0% identity (100.0% similar) in 625 aa overlap (1-625:1-625) 10 20 30 40 50 60 pF1KSD MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPEL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD MNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD GKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFRYSERYDPEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFRYSERYDPEP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD KSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISKFRRKDREDSPERCSDSDEEKKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISKFRRKDREDSPERCSDSDEEKKA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD RRGRSPKGEFKDEEETVTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHYTGDKASP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RRGRSPKGEFKDEEETVTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHYTGDKASP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD DQNASTHTPQSSVKTSVPSSKSSGDLVDLFDGTSQSTGGSADLFGGFADFGSAAASGSFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DQNASTHTPQSSVKTSVPSSKSSGDLVDLFDGTSQSTGGSADLFGGFADFGSAAASGSFP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SQVTATSGNGDFGDWSAFNQAPSGPVASSGEFFGSASQPAVELVSGSQSALGPPPAASNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SQVTATSGNGDFGDWSAFNQAPSGPVASSGEFFGSASQPAVELVSGSQSALGPPPAASNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD SDLFDLMGSSQATMTSSQSMNFSMMSTNTVGLGLPMSRSQNTDMVQKSVSKTLPSTWSDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SDLFDLMGSSQATMTSSQSMNFSMMSTNTVGLGLPMSRSQNTDMVQKSVSKTLPSTWSDP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD SVNISLDNLLPGMQPSKPQQPSLNTMIQQQNMQQPMNVMTQSFGAVNLSSPSNMLPVRPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SVNISLDNLLPGMQPSKPQQPSLNTMIQQQNMQQPMNVMTQSFGAVNLSSPSNMLPVRPQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD TNALIGGPMPMSMPNVMTGTMGMAPLGNTPMMNQSMMGMNMNIGMSAAGMGLTGTMGMGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 TNALIGGPMPMSMPNVMTGTMGMAPLGNTPMMNQSMMGMNMNIGMSAAGMGLTGTMGMGM 550 560 570 580 590 600 610 620 pF1KSD PNIAMTSGTVQPKQDAFANFANFSK ::::::::::::::::::::::::: NP_055 PNIAMTSGTVQPKQDAFANFANFSK 610 620 >>XP_016865576 (OMIM: 607265) PREDICTED: clathrin intera (518 aa) initn: 3365 init1: 3365 opt: 3365 Z-score: 2259.8 bits: 428.0 E(85289): 3.9e-119 Smith-Waterman score: 3365; 100.0% identity (100.0% similar) in 510 aa overlap (1-510:1-510) 10 20 30 40 50 60 pF1KSD MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPEL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD MNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD GKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFRYSERYDPEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFRYSERYDPEP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD KSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISKFRRKDREDSPERCSDSDEEKKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISKFRRKDREDSPERCSDSDEEKKA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD RRGRSPKGEFKDEEETVTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHYTGDKASP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRGRSPKGEFKDEEETVTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHYTGDKASP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD DQNASTHTPQSSVKTSVPSSKSSGDLVDLFDGTSQSTGGSADLFGGFADFGSAAASGSFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DQNASTHTPQSSVKTSVPSSKSSGDLVDLFDGTSQSTGGSADLFGGFADFGSAAASGSFP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SQVTATSGNGDFGDWSAFNQAPSGPVASSGEFFGSASQPAVELVSGSQSALGPPPAASNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQVTATSGNGDFGDWSAFNQAPSGPVASSGEFFGSASQPAVELVSGSQSALGPPPAASNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD SDLFDLMGSSQATMTSSQSMNFSMMSTNTVGLGLPMSRSQNTDMVQKSVSKTLPSTWSDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDLFDLMGSSQATMTSSQSMNFSMMSTNTVGLGLPMSRSQNTDMVQKSVSKTLPSTWSDP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD SVNISLDNLLPGMQPSKPQQPSLNTMIQQQNMQQPMNVMTQSFGAVNLSSPSNMLPVRPQ :::::::::::::::::::::::::::::: XP_016 SVNISLDNLLPGMQPSKPQQPSLNTMIQQQILLSVFVW 490 500 510 >>NP_001182484 (OMIM: 607265) clathrin interactor 1 isof (643 aa) initn: 3061 init1: 3032 opt: 3123 Z-score: 2097.1 bits: 398.2 E(85289): 4.5e-110 Smith-Waterman score: 4094; 97.2% identity (97.2% similar) in 643 aa overlap (1-625:1-643) 10 20 30 40 50 60 pF1KSD MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPEL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD MNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD GKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFRYSERYDPEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFRYSERYDPEP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD KSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISKFRRKDREDSPERCSDSDEEKKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISKFRRKDREDSPERCSDSDEEKKA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD RRGRSPKGEFKDEEETVTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHYTGDKASP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRGRSPKGEFKDEEETVTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHYTGDKASP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD DQNASTHTPQSSVKTSVPSSKSSGDLVDLFDGTSQSTGGSADLFGGFADFGSAAASGSFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQNASTHTPQSSVKTSVPSSKSSGDLVDLFDGTSQSTGGSADLFGGFADFGSAAASGSFP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SQVTATSGNGDFGDWSAFNQAPSGPVASSGEFFGSASQPAVELVSGSQSALGPPPAASNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQVTATSGNGDFGDWSAFNQAPSGPVASSGEFFGSASQPAVELVSGSQSALGPPPAASNS 370 380 390 400 410 420 430 440 450 460 pF1KSD SDLFDLMGSSQATMTSSQSMNFSMMSTNTVGLGLPMSRSQ------------------NT :::::::::::::::::::::::::::::::::::::::: :: NP_001 SDLFDLMGSSQATMTSSQSMNFSMMSTNTVGLGLPMSRSQPLQNVSTVLQKPNPLYNQNT 430 440 450 460 470 480 470 480 490 500 510 520 pF1KSD DMVQKSVSKTLPSTWSDPSVNISLDNLLPGMQPSKPQQPSLNTMIQQQNMQQPMNVMTQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DMVQKSVSKTLPSTWSDPSVNISLDNLLPGMQPSKPQQPSLNTMIQQQNMQQPMNVMTQS 490 500 510 520 530 540 530 540 550 560 570 580 pF1KSD FGAVNLSSPSNMLPVRPQTNALIGGPMPMSMPNVMTGTMGMAPLGNTPMMNQSMMGMNMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FGAVNLSSPSNMLPVRPQTNALIGGPMPMSMPNVMTGTMGMAPLGNTPMMNQSMMGMNMN 550 560 570 580 590 600 590 600 610 620 pF1KSD IGMSAAGMGLTGTMGMGMPNIAMTSGTVQPKQDAFANFANFSK ::::::::::::::::::::::::::::::::::::::::::: NP_001 IGMSAAGMGLTGTMGMGMPNIAMTSGTVQPKQDAFANFANFSK 610 620 630 640 >>XP_011533003 (OMIM: 607265) PREDICTED: clathrin intera (536 aa) initn: 3032 init1: 3032 opt: 3073 Z-score: 2065.0 bits: 392.0 E(85289): 2.8e-108 Smith-Waterman score: 3319; 96.6% identity (96.6% similar) in 528 aa overlap (1-510:1-528) 10 20 30 40 50 60 pF1KSD MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPEL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD MNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD GKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFRYSERYDPEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFRYSERYDPEP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD KSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISKFRRKDREDSPERCSDSDEEKKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISKFRRKDREDSPERCSDSDEEKKA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD RRGRSPKGEFKDEEETVTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHYTGDKASP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRGRSPKGEFKDEEETVTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHYTGDKASP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD DQNASTHTPQSSVKTSVPSSKSSGDLVDLFDGTSQSTGGSADLFGGFADFGSAAASGSFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DQNASTHTPQSSVKTSVPSSKSSGDLVDLFDGTSQSTGGSADLFGGFADFGSAAASGSFP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SQVTATSGNGDFGDWSAFNQAPSGPVASSGEFFGSASQPAVELVSGSQSALGPPPAASNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQVTATSGNGDFGDWSAFNQAPSGPVASSGEFFGSASQPAVELVSGSQSALGPPPAASNS 370 380 390 400 410 420 430 440 450 460 pF1KSD SDLFDLMGSSQATMTSSQSMNFSMMSTNTVGLGLPMSRSQ------------------NT :::::::::::::::::::::::::::::::::::::::: :: XP_011 SDLFDLMGSSQATMTSSQSMNFSMMSTNTVGLGLPMSRSQPLQNVSTVLQKPNPLYNQNT 430 440 450 460 470 480 470 480 490 500 510 520 pF1KSD DMVQKSVSKTLPSTWSDPSVNISLDNLLPGMQPSKPQQPSLNTMIQQQNMQQPMNVMTQS :::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DMVQKSVSKTLPSTWSDPSVNISLDNLLPGMQPSKPQQPSLNTMIQQQILLSVFVW 490 500 510 520 530 530 540 550 560 570 580 pF1KSD FGAVNLSSPSNMLPVRPQTNALIGGPMPMSMPNVMTGTMGMAPLGNTPMMNQSMMGMNMN >>XP_016865577 (OMIM: 607265) PREDICTED: clathrin intera (468 aa) initn: 3032 init1: 3032 opt: 3032 Z-score: 2038.6 bits: 387.0 E(85289): 8.2e-107 Smith-Waterman score: 3032; 100.0% identity (100.0% similar) in 460 aa overlap (1-460:1-460) 10 20 30 40 50 60 pF1KSD MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPEL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD MNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD GKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFRYSERYDPEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFRYSERYDPEP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD KSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISKFRRKDREDSPERCSDSDEEKKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISKFRRKDREDSPERCSDSDEEKKA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD RRGRSPKGEFKDEEETVTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHYTGDKASP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRGRSPKGEFKDEEETVTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHYTGDKASP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD DQNASTHTPQSSVKTSVPSSKSSGDLVDLFDGTSQSTGGSADLFGGFADFGSAAASGSFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DQNASTHTPQSSVKTSVPSSKSSGDLVDLFDGTSQSTGGSADLFGGFADFGSAAASGSFP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SQVTATSGNGDFGDWSAFNQAPSGPVASSGEFFGSASQPAVELVSGSQSALGPPPAASNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQVTATSGNGDFGDWSAFNQAPSGPVASSGEFFGSASQPAVELVSGSQSALGPPPAASNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD SDLFDLMGSSQATMTSSQSMNFSMMSTNTVGLGLPMSRSQNTDMVQKSVSKTLPSTWSDP :::::::::::::::::::::::::::::::::::::::: XP_016 SDLFDLMGSSQATMTSSQSMNFSMMSTNTVGLGLPMSRSQILVFGVLG 430 440 450 460 490 500 510 520 530 540 pF1KSD SVNISLDNLLPGMQPSKPQQPSLNTMIQQQNMQQPMNVMTQSFGAVNLSSPSNMLPVRPQ >>NP_001182485 (OMIM: 607265) clathrin interactor 1 isof (625 aa) initn: 2945 init1: 2916 opt: 3007 Z-score: 2020.1 bits: 383.9 E(85289): 8.9e-106 Smith-Waterman score: 3978; 97.1% identity (97.1% similar) in 625 aa overlap (19-625:1-625) 10 20 30 40 50 60 pF1KSD MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPEL :::::::::::::::::::::::::::::::::::::::::: NP_001 MNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPEL 10 20 30 40 70 80 90 100 110 120 pF1KSD MNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEH 50 60 70 80 90 100 130 140 150 160 170 180 pF1KSD GKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFRYSERYDPEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFRYSERYDPEP 110 120 130 140 150 160 190 200 210 220 230 240 pF1KSD KSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISKFRRKDREDSPERCSDSDEEKKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISKFRRKDREDSPERCSDSDEEKKA 170 180 190 200 210 220 250 260 270 280 290 300 pF1KSD RRGRSPKGEFKDEEETVTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHYTGDKASP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRGRSPKGEFKDEEETVTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHYTGDKASP 230 240 250 260 270 280 310 320 330 340 350 360 pF1KSD DQNASTHTPQSSVKTSVPSSKSSGDLVDLFDGTSQSTGGSADLFGGFADFGSAAASGSFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQNASTHTPQSSVKTSVPSSKSSGDLVDLFDGTSQSTGGSADLFGGFADFGSAAASGSFP 290 300 310 320 330 340 370 380 390 400 410 420 pF1KSD SQVTATSGNGDFGDWSAFNQAPSGPVASSGEFFGSASQPAVELVSGSQSALGPPPAASNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQVTATSGNGDFGDWSAFNQAPSGPVASSGEFFGSASQPAVELVSGSQSALGPPPAASNS 350 360 370 380 390 400 430 440 450 460 pF1KSD SDLFDLMGSSQATMTSSQSMNFSMMSTNTVGLGLPMSRSQ------------------NT :::::::::::::::::::::::::::::::::::::::: :: NP_001 SDLFDLMGSSQATMTSSQSMNFSMMSTNTVGLGLPMSRSQPLQNVSTVLQKPNPLYNQNT 410 420 430 440 450 460 470 480 490 500 510 520 pF1KSD DMVQKSVSKTLPSTWSDPSVNISLDNLLPGMQPSKPQQPSLNTMIQQQNMQQPMNVMTQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DMVQKSVSKTLPSTWSDPSVNISLDNLLPGMQPSKPQQPSLNTMIQQQNMQQPMNVMTQS 470 480 490 500 510 520 530 540 550 560 570 580 pF1KSD FGAVNLSSPSNMLPVRPQTNALIGGPMPMSMPNVMTGTMGMAPLGNTPMMNQSMMGMNMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FGAVNLSSPSNMLPVRPQTNALIGGPMPMSMPNVMTGTMGMAPLGNTPMMNQSMMGMNMN 530 540 550 560 570 580 590 600 610 620 pF1KSD IGMSAAGMGLTGTMGMGMPNIAMTSGTVQPKQDAFANFANFSK ::::::::::::::::::::::::::::::::::::::::::: NP_001 IGMSAAGMGLTGTMGMGMPNIAMTSGTVQPKQDAFANFANFSK 590 600 610 620 >>NP_001308192 (OMIM: 607262) epsin-1 isoform d [Homo sa (575 aa) initn: 369 init1: 340 opt: 630 Z-score: 437.2 bits: 90.9 E(85289): 1.3e-17 Smith-Waterman score: 665; 30.5% identity (55.7% similar) in 567 aa overlap (16-554:12-562) 10 20 30 40 50 60 pF1KSD MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPEL :.: :::: : ::::::..::::::..::.::: :. : :. NP_001 MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEI 10 20 30 40 50 70 80 90 100 110 120 pF1KSD MNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEH :.:.:.: :.:. ::::.:::.. :. :::..::::: . .:..: ...:.....::. NP_001 MSMIWKR-LNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRD 60 70 80 90 100 110 130 140 150 160 170 pF1KSD GKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGV---SSDSVGGFRYSERYD :::::.:.:.:.:.:: . .:.::::::: .: :.:.: . . :: .::. : . NP_001 GKDQGVNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQ 120 130 140 150 160 170 180 190 200 210 220 230 pF1KSD PEPKSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISKFRRKDRE--DSPERCSDSD :.:. .:: . . :. .: . .. . : : .. .:: :. :: .: NP_001 AWPQSSGEEEL-QLQLALAMSKEEADQPPSCGPEDDAQLQLALSLSREEHDKEERIRRGD 180 190 200 210 220 230 240 250 260 270 280 290 pF1KSD EEKKARRGRSPKGEFKDEEET--VTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHY . . . : : .::. . . . : :: : . .. .: . NP_001 DLRLQMAIEESKRETGGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSD 240 250 260 270 280 290 300 310 320 330 340 pF1KSD T-GDKASPDQNASTHTPQSSVKTSVP--SSKSSGDLVDLFDGTSQSTGG---SADLFGGF : : : . .. : . .: :: . :: ..: . : .:. NP_001 PWGGPPVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGS- 300 310 320 330 340 350 350 360 370 380 390 400 pF1KSD ADFGSAAASGSFPSQVTATSGNGDFGD-WSAFNQAPSGPVASSGEFFGSASQPAVELVSG .: :.. .:: :: . :.: :.. :: ...: : ..: :. . NP_001 SD-GGVPVSG--PSASDPWTPAPAFSDPWGGSPAKPSTNGTTAG---GFDTEPD-EFSDF 360 370 380 390 400 410 420 430 440 450 460 pF1KSD SQSALGPPPAASNSSDLFDLMGSSQATMTSSQSMNFSMMS-TNTVGLGLPMSRSQNTDMV .. . : ..:....: : : : .. .:. : ...:: : . : . NP_001 DRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPT 410 420 430 440 450 460 470 480 490 500 510 pF1KSD QKSVSKTLPSTWSDPSVN-ISLDNLL-------PGMQPSKPQQPSLN--TMIQQQNMQQP .:. : .. :.. ..::.:. :: . :.: :. . : . : :: NP_001 RKT-----PESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQP 470 480 490 500 510 520 520 530 540 550 560 570 pF1KSD MNVMTQSFGAVNLSSPSNMLPVRPQT--NALIGGP-MPMSMPNVMTGTMGMAPLGNTPMM : ... . :: : .: : : . : ::: .: :: NP_001 APPATLTLNQLRLS-PVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPFLL 530 540 550 560 570 580 590 600 610 620 pF1KSD NQSMMGMNMNIGMSAAGMGLTGTMGMGMPNIAMTSGTVQPKQDAFANFANFSK >>XP_011525182 (OMIM: 607262) PREDICTED: epsin-1 isoform (575 aa) initn: 369 init1: 340 opt: 630 Z-score: 437.2 bits: 90.9 E(85289): 1.3e-17 Smith-Waterman score: 665; 30.5% identity (55.7% similar) in 567 aa overlap (16-554:12-562) 10 20 30 40 50 60 pF1KSD MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPEL :.: :::: : ::::::..::::::..::.::: :. : :. XP_011 MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEI 10 20 30 40 50 70 80 90 100 110 120 pF1KSD MNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEH :.:.:.: :.:. ::::.:::.. :. :::..::::: . .:..: ...:.....::. XP_011 MSMIWKR-LNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRD 60 70 80 90 100 110 130 140 150 160 170 pF1KSD GKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGV---SSDSVGGFRYSERYD :::::.:.:.:.:.:: . .:.::::::: .: :.:.: . . :: .::. : . XP_011 GKDQGVNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQ 120 130 140 150 160 170 180 190 200 210 220 230 pF1KSD PEPKSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISKFRRKDRE--DSPERCSDSD :.:. .:: . . :. .: . .. . : : .. .:: :. :: .: XP_011 AWPQSSGEEEL-QLQLALAMSKEEADQPPSCGPEDDAQLQLALSLSREEHDKEERIRRGD 180 190 200 210 220 230 240 250 260 270 280 290 pF1KSD EEKKARRGRSPKGEFKDEEET--VTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHY . . . : : .::. . . . : :: : . .. .: . XP_011 DLRLQMAIEESKRETGGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSD 240 250 260 270 280 290 300 310 320 330 340 pF1KSD T-GDKASPDQNASTHTPQSSVKTSVP--SSKSSGDLVDLFDGTSQSTGG---SADLFGGF : : : . .. : . .: :: . :: ..: . : .:. XP_011 PWGGPPVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGS- 300 310 320 330 340 350 350 360 370 380 390 400 pF1KSD ADFGSAAASGSFPSQVTATSGNGDFGD-WSAFNQAPSGPVASSGEFFGSASQPAVELVSG .: :.. .:: :: . :.: :.. :: ...: : ..: :. . XP_011 SD-GGVPVSG--PSASDPWTPAPAFSDPWGGSPAKPSTNGTTAG---GFDTEPD-EFSDF 360 370 380 390 400 410 420 430 440 450 460 pF1KSD SQSALGPPPAASNSSDLFDLMGSSQATMTSSQSMNFSMMS-TNTVGLGLPMSRSQNTDMV .. . : ..:....: : : : .. .:. : ...:: : . : . XP_011 DRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPT 410 420 430 440 450 460 470 480 490 500 510 pF1KSD QKSVSKTLPSTWSDPSVN-ISLDNLL-------PGMQPSKPQQPSLN--TMIQQQNMQQP .:. : .. :.. ..::.:. :: . :.: :. . : . : :: XP_011 RKT-----PESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQP 470 480 490 500 510 520 520 530 540 550 560 570 pF1KSD MNVMTQSFGAVNLSSPSNMLPVRPQT--NALIGGP-MPMSMPNVMTGTMGMAPLGNTPMM : ... . :: : .: : : . : ::: .: :: XP_011 APPATLTLNQLRLS-PVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPFLL 530 540 550 560 570 580 590 600 610 620 pF1KSD NQSMMGMNMNIGMSAAGMGLTGTMGMGMPNIAMTSGTVQPKQDAFANFANFSK >>NP_001123544 (OMIM: 607262) epsin-1 isoform b [Homo sa (576 aa) initn: 369 init1: 340 opt: 625 Z-score: 433.9 bits: 90.3 E(85289): 2e-17 Smith-Waterman score: 661; 30.8% identity (55.9% similar) in 569 aa overlap (16-554:12-563) 10 20 30 40 50 60 pF1KSD MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPEL :.: :::: : ::::::..::::::..::.::: :. : :. NP_001 MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEI 10 20 30 40 50 70 80 90 100 110 120 pF1KSD MNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEH :.:.:.: :.:. ::::.:::.. :. :::..::::: . .:..: ...:.....::. NP_001 MSMIWKR-LNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRD 60 70 80 90 100 110 130 140 150 160 170 pF1KSD GKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGV---SSDSVGGFRYSERYD :::::.:.:.:.:.:: . .:.::::::: .: :.:.: . . :: .::. : . NP_001 GKDQGVNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQ 120 130 140 150 160 170 180 190 200 210 220 230 pF1KSD PEPKSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISKFRRKDRE--DSPERCSDSD :.:. .:: . . :. .: . .. . : : .. .:: :. :: .: NP_001 AWPQSSGEEEL-QLQLALAMSKEEADQPPSCGPEDDAQLQLALSLSREEHDKEERIRRGD 180 190 200 210 220 230 240 250 260 270 280 290 pF1KSD EEKKARRGRSPKGEFKDEEET--VTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHY . . . : : .::. . . . : :: : . .. .: . NP_001 DLRLQMAIEESKRETGGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSD 240 250 260 270 280 290 300 310 320 330 340 pF1KSD T-GDKASPDQNASTHTPQSSVKTSVP--SSKSSGDLVDLFDGTSQSTGG---SADLFGGF : : : . .. : . .: :: . :: ..: . : .:. NP_001 PWGGPPVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGS- 300 310 320 330 340 350 350 360 370 380 390 400 pF1KSD ADFGSAAASGSFPSQVTATSGNGDFGD-WSAFNQAPS--GPVASSGEFFGSASQPAVELV .: :.. .:: :: . :.: :.. :: : .:..: : . .: :. NP_001 SD-GGVPVSG--PSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGG--FDT--EPD-EFS 360 370 380 390 400 410 420 430 440 450 460 pF1KSD SGSQSALGPPPAASNSSDLFDLMGSSQATMTSSQSMNFSMMS-TNTVGLGLPMSRSQNTD . .. . : ..:....: : : : .. .:. : ...:: : . : NP_001 DFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTP 410 420 430 440 450 460 470 480 490 500 510 pF1KSD MVQKSVSKTLPSTWSDPSVN-ISLDNLL-------PGMQPSKPQQPSLN--TMIQQQNMQ ..:. : .. :.. ..::.:. :: . :.: :. . : . : NP_001 PTRKT-----PESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPF 470 480 490 500 510 520 520 530 540 550 560 570 pF1KSD QPMNVMTQSFGAVNLSSPSNMLPVRPQT--NALIGGP-MPMSMPNVMTGTMGMAPLGNTP :: : ... . :: : .: : : . : ::: .: :: NP_001 QPAPPATLTLNQLRLS-PVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPFLL 530 540 550 560 570 580 590 600 610 620 pF1KSD MMNQSMMGMNMNIGMSAAGMGLTGTMGMGMPNIAMTSGTVQPKQDAFANFANFSK >>XP_005258886 (OMIM: 607262) PREDICTED: epsin-1 isoform (576 aa) initn: 369 init1: 340 opt: 625 Z-score: 433.9 bits: 90.3 E(85289): 2e-17 Smith-Waterman score: 661; 30.8% identity (55.9% similar) in 569 aa overlap (16-554:12-563) 10 20 30 40 50 60 pF1KSD MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPEL :.: :::: : ::::::..::::::..::.::: :. : :. XP_005 MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEI 10 20 30 40 50 70 80 90 100 110 120 pF1KSD MNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEH :.:.:.: :.:. ::::.:::.. :. :::..::::: . .:..: ...:.....::. XP_005 MSMIWKR-LNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRD 60 70 80 90 100 110 130 140 150 160 170 pF1KSD GKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGV---SSDSVGGFRYSERYD :::::.:.:.:.:.:: . .:.::::::: .: :.:.: . . :: .::. : . XP_005 GKDQGVNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQ 120 130 140 150 160 170 180 190 200 210 220 230 pF1KSD PEPKSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISKFRRKDRE--DSPERCSDSD :.:. .:: . . :. .: . .. . : : .. .:: :. :: .: XP_005 AWPQSSGEEEL-QLQLALAMSKEEADQPPSCGPEDDAQLQLALSLSREEHDKEERIRRGD 180 190 200 210 220 230 240 250 260 270 280 290 pF1KSD EEKKARRGRSPKGEFKDEEET--VTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHY . . . : : .::. . . . : :: : . .. .: . XP_005 DLRLQMAIEESKRETGGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSD 240 250 260 270 280 290 300 310 320 330 340 pF1KSD T-GDKASPDQNASTHTPQSSVKTSVP--SSKSSGDLVDLFDGTSQSTGG---SADLFGGF : : : . .. : . .: :: . :: ..: . : .:. XP_005 PWGGPPVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGS- 300 310 320 330 340 350 350 360 370 380 390 400 pF1KSD ADFGSAAASGSFPSQVTATSGNGDFGD-WSAFNQAPS--GPVASSGEFFGSASQPAVELV .: :.. .:: :: . :.: :.. :: : .:..: : . .: :. XP_005 SD-GGVPVSG--PSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGG--FDT--EPD-EFS 360 370 380 390 400 410 420 430 440 450 460 pF1KSD SGSQSALGPPPAASNSSDLFDLMGSSQATMTSSQSMNFSMMS-TNTVGLGLPMSRSQNTD . .. . : ..:....: : : : .. .:. : ...:: : . : XP_005 DFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTP 410 420 430 440 450 460 470 480 490 500 510 pF1KSD MVQKSVSKTLPSTWSDPSVN-ISLDNLL-------PGMQPSKPQQPSLN--TMIQQQNMQ ..:. : .. :.. ..::.:. :: . :.: :. . : . : XP_005 PTRKT-----PESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPF 470 480 490 500 510 520 520 530 540 550 560 570 pF1KSD QPMNVMTQSFGAVNLSSPSNMLPVRPQT--NALIGGP-MPMSMPNVMTGTMGMAPLGNTP :: : ... . :: : .: : : . : ::: .: :: XP_005 QPAPPATLTLNQLRLS-PVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPFLL 530 540 550 560 570 580 590 600 610 620 pF1KSD MMNQSMMGMNMNIGMSAAGMGLTGTMGMGMPNIAMTSGTVQPKQDAFANFANFSK 625 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 00:26:07 2016 done: Thu Nov 3 00:26:09 2016 Total Scan time: 10.910 Total Display time: 0.140 Function used was FASTA [36.3.4 Apr, 2011]