FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0211, 1267 aa 1>>>pF1KSDA0211 1267 - 1267 aa - 1267 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.9885+/-0.000428; mu= -0.3566+/- 0.027 mean_var=574.1870+/-141.191, 0's: 0 Z-trim(122.7): 106 B-trim: 2380 in 1/56 Lambda= 0.053524 statistics sampled from 40894 (41128) to 40894 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.778), E-opt: 0.2 (0.482), width: 16 Scan time: 12.120 The best scores are: opt bits E(85289) XP_011520548 (OMIM: 251300,613624) PREDICTED: zinc (1267) 8738 691.2 1.2e-197 NP_055445 (OMIM: 251300,613624) zinc finger protei (1267) 8738 691.2 1.2e-197 XP_011520549 (OMIM: 251300,613624) PREDICTED: zinc (1267) 8738 691.2 1.2e-197 XP_005255053 (OMIM: 251300,613624) PREDICTED: zinc (1267) 8738 691.2 1.2e-197 XP_016878223 (OMIM: 251300,613624) PREDICTED: zinc (1267) 8738 691.2 1.2e-197 XP_011520550 (OMIM: 251300,613624) PREDICTED: zinc (1092) 7551 599.5 4.2e-170 XP_011508113 (OMIM: 610568,616833) PREDICTED: zinc (1178) 754 74.6 4.3e-12 XP_011508114 (OMIM: 610568,616833) PREDICTED: zinc (1237) 641 65.9 1.9e-09 NP_001291692 (OMIM: 610568,616833) zinc finger pro (1237) 641 65.9 1.9e-09 NP_065883 (OMIM: 610568,616833) zinc finger protei (1237) 641 65.9 1.9e-09 XP_011508115 (OMIM: 610568,616833) PREDICTED: zinc (1237) 641 65.9 1.9e-09 NP_001291693 (OMIM: 610568,616833) zinc finger pro (1237) 641 65.9 1.9e-09 XP_005245423 (OMIM: 610568,616833) PREDICTED: zinc (1246) 641 66.0 1.9e-09 >>XP_011520548 (OMIM: 251300,613624) PREDICTED: zinc fin (1267 aa) initn: 8738 init1: 8738 opt: 8738 Z-score: 3669.6 bits: 691.2 E(85289): 1.2e-197 Smith-Waterman score: 8738; 99.9% identity (100.0% similar) in 1267 aa overlap (1-1267:1-1267) 10 20 30 40 50 60 pF1KSD MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKPPGICMDESVSLSHSGSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKPPGICMDESVSLSHSGSA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD PDVPAVSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLPPDPHNCGKFDSTFMNGDSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDVPAVSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLPPDPHNCGKFDSTFMNGDSA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD RSFPGKLEPPKSEPLPTFNQFSPISSPEPEDPIKDNGFGIKPKHSDSYFPPPLGCGAVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSFPGKLEPPKSEPLPTFNQFSPISSPEPEDPIKDNGFGIKPKHSDSYFPPPLGCGAVGG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD PVLEALAKFPVPELHMFDHFCKKEPKPEPLPLGSQQEHEQSGQNTVEPHKDPDATRFFGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVLEALAKFPVPELHMFDHFCKKEPKPEPLPLGSQQEHEQSGQNTVEPHKDPDATRFFGE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD ALEFNSHPSNSIGESKGLARELGTCSSVPPRQRLKPAHSKLSSCVAALVALQAKRVASVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALEFNSHPSNSIGESKGLARELGTCSSVPPRQRLKPAHSKLSSCVAALVALQAKRVASVT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD KEDQPGHTKDLSGPTKESSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KEDQPGHTKDLSGPTKESSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPVGSPLGSAIAEAPSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPVGSPLGSAIAEAPSE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD MPGDEVPVEEHFPEAGTNSGSPQGARKGDESMTKASDSSSPSCSSGPRVPKGAAPGSQTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPGDEVPVEEHFPEAGTNSGSPQGARKGDESMTKASDSSSPSCSSGPRVPKGAAPGSQTG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KKQQSTALQASTLAPANLLPKAVHLANLNLVPHSVAASVTAKSSVQRRSQPQLTQMSVPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKQQSTALQASTLAPANLLPKAVHLANLNLVPHSVAASVTAKSSVQRRSQPQLTQMSVPL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD VHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGYCCLECGDAFALEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGYCCLECGDAFALEK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD SLSQHYGRRSVHIEVLCTLCSKTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLSQHYGRRSVHIEVLCTLCSKTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD MFVSAPVNSTAPAAPAPSSSPKHGLTSGSASPPPPALPLYPDPVRLIRYSIKCLECHKQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MFVSAPVNSTAPAAPAPSSSPKHGLTSGSASPPPPALPLYPDPVRLIRYSIKCLECHKQM 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD RDYMVLAAHFQRTTEETEGLTCQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGVLCRSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDYMVLAAHFQRTTEETEGLTCQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGVLCRSA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD YFQTHVKENCLHYARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YFQTHVKENCLHYARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTAS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD STADHSATQHPTQPHRPSQLIYKCSCEMVFNKKRHIQQHFYQNVSKTQVGVFKCPECPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STADHSATQHPTQPHRPSQLIYKCSCEMVFNKKRHIQQHFYQNVSKTQVGVFKCPECPLL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD FVQKPELMQHVKSTHGVPRNVDELSNLQSSADTSSSRPGSRVPTEPPATSVAARSSSLPS :::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::: XP_011 FVQKPELMQHVKSTHGVPRNVDELSSLQSSADTSSSRPGSRVPTEPPATSVAARSSSLPS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD GRWGRPEAHRRVEARPRLRNTGWTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQCEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRWGRPEAHRRVEARPRLRNTGWTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQCEQ 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD SFHTPNSLRKHIRNNHDTVKKFYTCGYCTEDSPSFPRPSLLESHISLMHGIRNPDLSQTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SFHTPNSLRKHIRNNHDTVKKFYTCGYCTEDSPSFPRPSLLESHISLMHGIRNPDLSQTS 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD KVKPPGGHSPQVNHLKRPVSGVGDAPGTSNGATVSSTKRHKSLFQCAKCSFATDSGLEFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVKPPGGHSPQVNHLKRPVSGVGDAPGTSNGATVSSTKRHKSLFQCAKCSFATDSGLEFQ 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD SHIPQHQVDSSTAQCLLCGLCYTSASSLSRHLFIVHKVRDQEEEEEEEAAAAEMAVEVAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SHIPQHQVDSSTAQCLLCGLCYTSASSLSRHLFIVHKVRDQEEEEEEEAAAAEMAVEVAE 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD PEEGSGEEVPMETRENGLEECAGEPLSADPEARRLLGPAPEDDGGHNDHSQPQASQDQDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEEGSGEEVPMETRENGLEECAGEPLSADPEARRLLGPAPEDDGGHNDHSQPQASQDQDS 1210 1220 1230 1240 1250 1260 pF1KSD HTLSPQV ::::::: XP_011 HTLSPQV >>NP_055445 (OMIM: 251300,613624) zinc finger protein 59 (1267 aa) initn: 8738 init1: 8738 opt: 8738 Z-score: 3669.6 bits: 691.2 E(85289): 1.2e-197 Smith-Waterman score: 8738; 99.9% identity (100.0% similar) in 1267 aa overlap (1-1267:1-1267) 10 20 30 40 50 60 pF1KSD MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKPPGICMDESVSLSHSGSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKPPGICMDESVSLSHSGSA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD PDVPAVSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLPPDPHNCGKFDSTFMNGDSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PDVPAVSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLPPDPHNCGKFDSTFMNGDSA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD RSFPGKLEPPKSEPLPTFNQFSPISSPEPEDPIKDNGFGIKPKHSDSYFPPPLGCGAVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RSFPGKLEPPKSEPLPTFNQFSPISSPEPEDPIKDNGFGIKPKHSDSYFPPPLGCGAVGG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD PVLEALAKFPVPELHMFDHFCKKEPKPEPLPLGSQQEHEQSGQNTVEPHKDPDATRFFGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PVLEALAKFPVPELHMFDHFCKKEPKPEPLPLGSQQEHEQSGQNTVEPHKDPDATRFFGE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD ALEFNSHPSNSIGESKGLARELGTCSSVPPRQRLKPAHSKLSSCVAALVALQAKRVASVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ALEFNSHPSNSIGESKGLARELGTCSSVPPRQRLKPAHSKLSSCVAALVALQAKRVASVT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD KEDQPGHTKDLSGPTKESSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KEDQPGHTKDLSGPTKESSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPVGSPLGSAIAEAPSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPVGSPLGSAIAEAPSE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD MPGDEVPVEEHFPEAGTNSGSPQGARKGDESMTKASDSSSPSCSSGPRVPKGAAPGSQTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MPGDEVPVEEHFPEAGTNSGSPQGARKGDESMTKASDSSSPSCSSGPRVPKGAAPGSQTG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KKQQSTALQASTLAPANLLPKAVHLANLNLVPHSVAASVTAKSSVQRRSQPQLTQMSVPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KKQQSTALQASTLAPANLLPKAVHLANLNLVPHSVAASVTAKSSVQRRSQPQLTQMSVPL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD VHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGYCCLECGDAFALEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGYCCLECGDAFALEK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD SLSQHYGRRSVHIEVLCTLCSKTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SLSQHYGRRSVHIEVLCTLCSKTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD MFVSAPVNSTAPAAPAPSSSPKHGLTSGSASPPPPALPLYPDPVRLIRYSIKCLECHKQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MFVSAPVNSTAPAAPAPSSSPKHGLTSGSASPPPPALPLYPDPVRLIRYSIKCLECHKQM 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD RDYMVLAAHFQRTTEETEGLTCQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGVLCRSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RDYMVLAAHFQRTTEETEGLTCQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGVLCRSA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD YFQTHVKENCLHYARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 YFQTHVKENCLHYARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTAS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD STADHSATQHPTQPHRPSQLIYKCSCEMVFNKKRHIQQHFYQNVSKTQVGVFKCPECPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 STADHSATQHPTQPHRPSQLIYKCSCEMVFNKKRHIQQHFYQNVSKTQVGVFKCPECPLL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD FVQKPELMQHVKSTHGVPRNVDELSNLQSSADTSSSRPGSRVPTEPPATSVAARSSSLPS :::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::: NP_055 FVQKPELMQHVKSTHGVPRNVDELSSLQSSADTSSSRPGSRVPTEPPATSVAARSSSLPS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD GRWGRPEAHRRVEARPRLRNTGWTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQCEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GRWGRPEAHRRVEARPRLRNTGWTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQCEQ 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD SFHTPNSLRKHIRNNHDTVKKFYTCGYCTEDSPSFPRPSLLESHISLMHGIRNPDLSQTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SFHTPNSLRKHIRNNHDTVKKFYTCGYCTEDSPSFPRPSLLESHISLMHGIRNPDLSQTS 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD KVKPPGGHSPQVNHLKRPVSGVGDAPGTSNGATVSSTKRHKSLFQCAKCSFATDSGLEFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KVKPPGGHSPQVNHLKRPVSGVGDAPGTSNGATVSSTKRHKSLFQCAKCSFATDSGLEFQ 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD SHIPQHQVDSSTAQCLLCGLCYTSASSLSRHLFIVHKVRDQEEEEEEEAAAAEMAVEVAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SHIPQHQVDSSTAQCLLCGLCYTSASSLSRHLFIVHKVRDQEEEEEEEAAAAEMAVEVAE 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD PEEGSGEEVPMETRENGLEECAGEPLSADPEARRLLGPAPEDDGGHNDHSQPQASQDQDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PEEGSGEEVPMETRENGLEECAGEPLSADPEARRLLGPAPEDDGGHNDHSQPQASQDQDS 1210 1220 1230 1240 1250 1260 pF1KSD HTLSPQV ::::::: NP_055 HTLSPQV >>XP_011520549 (OMIM: 251300,613624) PREDICTED: zinc fin (1267 aa) initn: 8738 init1: 8738 opt: 8738 Z-score: 3669.6 bits: 691.2 E(85289): 1.2e-197 Smith-Waterman score: 8738; 99.9% identity (100.0% similar) in 1267 aa overlap (1-1267:1-1267) 10 20 30 40 50 60 pF1KSD MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKPPGICMDESVSLSHSGSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKPPGICMDESVSLSHSGSA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD PDVPAVSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLPPDPHNCGKFDSTFMNGDSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDVPAVSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLPPDPHNCGKFDSTFMNGDSA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD RSFPGKLEPPKSEPLPTFNQFSPISSPEPEDPIKDNGFGIKPKHSDSYFPPPLGCGAVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSFPGKLEPPKSEPLPTFNQFSPISSPEPEDPIKDNGFGIKPKHSDSYFPPPLGCGAVGG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD PVLEALAKFPVPELHMFDHFCKKEPKPEPLPLGSQQEHEQSGQNTVEPHKDPDATRFFGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVLEALAKFPVPELHMFDHFCKKEPKPEPLPLGSQQEHEQSGQNTVEPHKDPDATRFFGE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD ALEFNSHPSNSIGESKGLARELGTCSSVPPRQRLKPAHSKLSSCVAALVALQAKRVASVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALEFNSHPSNSIGESKGLARELGTCSSVPPRQRLKPAHSKLSSCVAALVALQAKRVASVT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD KEDQPGHTKDLSGPTKESSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KEDQPGHTKDLSGPTKESSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPVGSPLGSAIAEAPSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPVGSPLGSAIAEAPSE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD MPGDEVPVEEHFPEAGTNSGSPQGARKGDESMTKASDSSSPSCSSGPRVPKGAAPGSQTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPGDEVPVEEHFPEAGTNSGSPQGARKGDESMTKASDSSSPSCSSGPRVPKGAAPGSQTG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KKQQSTALQASTLAPANLLPKAVHLANLNLVPHSVAASVTAKSSVQRRSQPQLTQMSVPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKQQSTALQASTLAPANLLPKAVHLANLNLVPHSVAASVTAKSSVQRRSQPQLTQMSVPL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD VHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGYCCLECGDAFALEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGYCCLECGDAFALEK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD SLSQHYGRRSVHIEVLCTLCSKTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLSQHYGRRSVHIEVLCTLCSKTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD MFVSAPVNSTAPAAPAPSSSPKHGLTSGSASPPPPALPLYPDPVRLIRYSIKCLECHKQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MFVSAPVNSTAPAAPAPSSSPKHGLTSGSASPPPPALPLYPDPVRLIRYSIKCLECHKQM 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD RDYMVLAAHFQRTTEETEGLTCQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGVLCRSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDYMVLAAHFQRTTEETEGLTCQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGVLCRSA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD YFQTHVKENCLHYARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YFQTHVKENCLHYARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTAS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD STADHSATQHPTQPHRPSQLIYKCSCEMVFNKKRHIQQHFYQNVSKTQVGVFKCPECPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STADHSATQHPTQPHRPSQLIYKCSCEMVFNKKRHIQQHFYQNVSKTQVGVFKCPECPLL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD FVQKPELMQHVKSTHGVPRNVDELSNLQSSADTSSSRPGSRVPTEPPATSVAARSSSLPS :::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::: XP_011 FVQKPELMQHVKSTHGVPRNVDELSSLQSSADTSSSRPGSRVPTEPPATSVAARSSSLPS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD GRWGRPEAHRRVEARPRLRNTGWTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQCEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRWGRPEAHRRVEARPRLRNTGWTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQCEQ 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD SFHTPNSLRKHIRNNHDTVKKFYTCGYCTEDSPSFPRPSLLESHISLMHGIRNPDLSQTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SFHTPNSLRKHIRNNHDTVKKFYTCGYCTEDSPSFPRPSLLESHISLMHGIRNPDLSQTS 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD KVKPPGGHSPQVNHLKRPVSGVGDAPGTSNGATVSSTKRHKSLFQCAKCSFATDSGLEFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVKPPGGHSPQVNHLKRPVSGVGDAPGTSNGATVSSTKRHKSLFQCAKCSFATDSGLEFQ 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD SHIPQHQVDSSTAQCLLCGLCYTSASSLSRHLFIVHKVRDQEEEEEEEAAAAEMAVEVAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SHIPQHQVDSSTAQCLLCGLCYTSASSLSRHLFIVHKVRDQEEEEEEEAAAAEMAVEVAE 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD PEEGSGEEVPMETRENGLEECAGEPLSADPEARRLLGPAPEDDGGHNDHSQPQASQDQDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEEGSGEEVPMETRENGLEECAGEPLSADPEARRLLGPAPEDDGGHNDHSQPQASQDQDS 1210 1220 1230 1240 1250 1260 pF1KSD HTLSPQV ::::::: XP_011 HTLSPQV >>XP_005255053 (OMIM: 251300,613624) PREDICTED: zinc fin (1267 aa) initn: 8738 init1: 8738 opt: 8738 Z-score: 3669.6 bits: 691.2 E(85289): 1.2e-197 Smith-Waterman score: 8738; 99.9% identity (100.0% similar) in 1267 aa overlap (1-1267:1-1267) 10 20 30 40 50 60 pF1KSD MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKPPGICMDESVSLSHSGSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKPPGICMDESVSLSHSGSA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD PDVPAVSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLPPDPHNCGKFDSTFMNGDSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PDVPAVSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLPPDPHNCGKFDSTFMNGDSA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD RSFPGKLEPPKSEPLPTFNQFSPISSPEPEDPIKDNGFGIKPKHSDSYFPPPLGCGAVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RSFPGKLEPPKSEPLPTFNQFSPISSPEPEDPIKDNGFGIKPKHSDSYFPPPLGCGAVGG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD PVLEALAKFPVPELHMFDHFCKKEPKPEPLPLGSQQEHEQSGQNTVEPHKDPDATRFFGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PVLEALAKFPVPELHMFDHFCKKEPKPEPLPLGSQQEHEQSGQNTVEPHKDPDATRFFGE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD ALEFNSHPSNSIGESKGLARELGTCSSVPPRQRLKPAHSKLSSCVAALVALQAKRVASVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ALEFNSHPSNSIGESKGLARELGTCSSVPPRQRLKPAHSKLSSCVAALVALQAKRVASVT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD KEDQPGHTKDLSGPTKESSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KEDQPGHTKDLSGPTKESSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPVGSPLGSAIAEAPSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPVGSPLGSAIAEAPSE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD MPGDEVPVEEHFPEAGTNSGSPQGARKGDESMTKASDSSSPSCSSGPRVPKGAAPGSQTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPGDEVPVEEHFPEAGTNSGSPQGARKGDESMTKASDSSSPSCSSGPRVPKGAAPGSQTG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KKQQSTALQASTLAPANLLPKAVHLANLNLVPHSVAASVTAKSSVQRRSQPQLTQMSVPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KKQQSTALQASTLAPANLLPKAVHLANLNLVPHSVAASVTAKSSVQRRSQPQLTQMSVPL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD VHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGYCCLECGDAFALEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGYCCLECGDAFALEK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD SLSQHYGRRSVHIEVLCTLCSKTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SLSQHYGRRSVHIEVLCTLCSKTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD MFVSAPVNSTAPAAPAPSSSPKHGLTSGSASPPPPALPLYPDPVRLIRYSIKCLECHKQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MFVSAPVNSTAPAAPAPSSSPKHGLTSGSASPPPPALPLYPDPVRLIRYSIKCLECHKQM 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD RDYMVLAAHFQRTTEETEGLTCQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGVLCRSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RDYMVLAAHFQRTTEETEGLTCQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGVLCRSA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD YFQTHVKENCLHYARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YFQTHVKENCLHYARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTAS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD STADHSATQHPTQPHRPSQLIYKCSCEMVFNKKRHIQQHFYQNVSKTQVGVFKCPECPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 STADHSATQHPTQPHRPSQLIYKCSCEMVFNKKRHIQQHFYQNVSKTQVGVFKCPECPLL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD FVQKPELMQHVKSTHGVPRNVDELSNLQSSADTSSSRPGSRVPTEPPATSVAARSSSLPS :::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::: XP_005 FVQKPELMQHVKSTHGVPRNVDELSSLQSSADTSSSRPGSRVPTEPPATSVAARSSSLPS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD GRWGRPEAHRRVEARPRLRNTGWTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQCEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GRWGRPEAHRRVEARPRLRNTGWTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQCEQ 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD SFHTPNSLRKHIRNNHDTVKKFYTCGYCTEDSPSFPRPSLLESHISLMHGIRNPDLSQTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SFHTPNSLRKHIRNNHDTVKKFYTCGYCTEDSPSFPRPSLLESHISLMHGIRNPDLSQTS 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD KVKPPGGHSPQVNHLKRPVSGVGDAPGTSNGATVSSTKRHKSLFQCAKCSFATDSGLEFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KVKPPGGHSPQVNHLKRPVSGVGDAPGTSNGATVSSTKRHKSLFQCAKCSFATDSGLEFQ 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD SHIPQHQVDSSTAQCLLCGLCYTSASSLSRHLFIVHKVRDQEEEEEEEAAAAEMAVEVAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SHIPQHQVDSSTAQCLLCGLCYTSASSLSRHLFIVHKVRDQEEEEEEEAAAAEMAVEVAE 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD PEEGSGEEVPMETRENGLEECAGEPLSADPEARRLLGPAPEDDGGHNDHSQPQASQDQDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PEEGSGEEVPMETRENGLEECAGEPLSADPEARRLLGPAPEDDGGHNDHSQPQASQDQDS 1210 1220 1230 1240 1250 1260 pF1KSD HTLSPQV ::::::: XP_005 HTLSPQV >>XP_016878223 (OMIM: 251300,613624) PREDICTED: zinc fin (1267 aa) initn: 8738 init1: 8738 opt: 8738 Z-score: 3669.6 bits: 691.2 E(85289): 1.2e-197 Smith-Waterman score: 8738; 99.9% identity (100.0% similar) in 1267 aa overlap (1-1267:1-1267) 10 20 30 40 50 60 pF1KSD MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKPPGICMDESVSLSHSGSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKPPGICMDESVSLSHSGSA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD PDVPAVSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLPPDPHNCGKFDSTFMNGDSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDVPAVSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLPPDPHNCGKFDSTFMNGDSA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD RSFPGKLEPPKSEPLPTFNQFSPISSPEPEDPIKDNGFGIKPKHSDSYFPPPLGCGAVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSFPGKLEPPKSEPLPTFNQFSPISSPEPEDPIKDNGFGIKPKHSDSYFPPPLGCGAVGG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD PVLEALAKFPVPELHMFDHFCKKEPKPEPLPLGSQQEHEQSGQNTVEPHKDPDATRFFGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PVLEALAKFPVPELHMFDHFCKKEPKPEPLPLGSQQEHEQSGQNTVEPHKDPDATRFFGE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD ALEFNSHPSNSIGESKGLARELGTCSSVPPRQRLKPAHSKLSSCVAALVALQAKRVASVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALEFNSHPSNSIGESKGLARELGTCSSVPPRQRLKPAHSKLSSCVAALVALQAKRVASVT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD KEDQPGHTKDLSGPTKESSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KEDQPGHTKDLSGPTKESSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPVGSPLGSAIAEAPSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPVGSPLGSAIAEAPSE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD MPGDEVPVEEHFPEAGTNSGSPQGARKGDESMTKASDSSSPSCSSGPRVPKGAAPGSQTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPGDEVPVEEHFPEAGTNSGSPQGARKGDESMTKASDSSSPSCSSGPRVPKGAAPGSQTG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KKQQSTALQASTLAPANLLPKAVHLANLNLVPHSVAASVTAKSSVQRRSQPQLTQMSVPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKQQSTALQASTLAPANLLPKAVHLANLNLVPHSVAASVTAKSSVQRRSQPQLTQMSVPL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD VHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGYCCLECGDAFALEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGYCCLECGDAFALEK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD SLSQHYGRRSVHIEVLCTLCSKTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLSQHYGRRSVHIEVLCTLCSKTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD MFVSAPVNSTAPAAPAPSSSPKHGLTSGSASPPPPALPLYPDPVRLIRYSIKCLECHKQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MFVSAPVNSTAPAAPAPSSSPKHGLTSGSASPPPPALPLYPDPVRLIRYSIKCLECHKQM 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD RDYMVLAAHFQRTTEETEGLTCQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGVLCRSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDYMVLAAHFQRTTEETEGLTCQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGVLCRSA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD YFQTHVKENCLHYARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YFQTHVKENCLHYARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTAS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD STADHSATQHPTQPHRPSQLIYKCSCEMVFNKKRHIQQHFYQNVSKTQVGVFKCPECPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STADHSATQHPTQPHRPSQLIYKCSCEMVFNKKRHIQQHFYQNVSKTQVGVFKCPECPLL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD FVQKPELMQHVKSTHGVPRNVDELSNLQSSADTSSSRPGSRVPTEPPATSVAARSSSLPS :::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::: XP_016 FVQKPELMQHVKSTHGVPRNVDELSSLQSSADTSSSRPGSRVPTEPPATSVAARSSSLPS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD GRWGRPEAHRRVEARPRLRNTGWTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQCEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GRWGRPEAHRRVEARPRLRNTGWTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQCEQ 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD SFHTPNSLRKHIRNNHDTVKKFYTCGYCTEDSPSFPRPSLLESHISLMHGIRNPDLSQTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SFHTPNSLRKHIRNNHDTVKKFYTCGYCTEDSPSFPRPSLLESHISLMHGIRNPDLSQTS 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD KVKPPGGHSPQVNHLKRPVSGVGDAPGTSNGATVSSTKRHKSLFQCAKCSFATDSGLEFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVKPPGGHSPQVNHLKRPVSGVGDAPGTSNGATVSSTKRHKSLFQCAKCSFATDSGLEFQ 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD SHIPQHQVDSSTAQCLLCGLCYTSASSLSRHLFIVHKVRDQEEEEEEEAAAAEMAVEVAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SHIPQHQVDSSTAQCLLCGLCYTSASSLSRHLFIVHKVRDQEEEEEEEAAAAEMAVEVAE 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD PEEGSGEEVPMETRENGLEECAGEPLSADPEARRLLGPAPEDDGGHNDHSQPQASQDQDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEEGSGEEVPMETRENGLEECAGEPLSADPEARRLLGPAPEDDGGHNDHSQPQASQDQDS 1210 1220 1230 1240 1250 1260 pF1KSD HTLSPQV ::::::: XP_016 HTLSPQV >>XP_011520550 (OMIM: 251300,613624) PREDICTED: zinc fin (1092 aa) initn: 7551 init1: 7551 opt: 7551 Z-score: 3175.0 bits: 599.5 E(85289): 4.2e-170 Smith-Waterman score: 7551; 99.9% identity (100.0% similar) in 1091 aa overlap (1-1091:1-1091) 10 20 30 40 50 60 pF1KSD MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKPPGICMDESVSLSHSGSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKPPGICMDESVSLSHSGSA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD PDVPAVSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLPPDPHNCGKFDSTFMNGDSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDVPAVSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLPPDPHNCGKFDSTFMNGDSA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD RSFPGKLEPPKSEPLPTFNQFSPISSPEPEDPIKDNGFGIKPKHSDSYFPPPLGCGAVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSFPGKLEPPKSEPLPTFNQFSPISSPEPEDPIKDNGFGIKPKHSDSYFPPPLGCGAVGG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD PVLEALAKFPVPELHMFDHFCKKEPKPEPLPLGSQQEHEQSGQNTVEPHKDPDATRFFGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVLEALAKFPVPELHMFDHFCKKEPKPEPLPLGSQQEHEQSGQNTVEPHKDPDATRFFGE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD ALEFNSHPSNSIGESKGLARELGTCSSVPPRQRLKPAHSKLSSCVAALVALQAKRVASVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALEFNSHPSNSIGESKGLARELGTCSSVPPRQRLKPAHSKLSSCVAALVALQAKRVASVT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD KEDQPGHTKDLSGPTKESSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KEDQPGHTKDLSGPTKESSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPVGSPLGSAIAEAPSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPVGSPLGSAIAEAPSE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD MPGDEVPVEEHFPEAGTNSGSPQGARKGDESMTKASDSSSPSCSSGPRVPKGAAPGSQTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPGDEVPVEEHFPEAGTNSGSPQGARKGDESMTKASDSSSPSCSSGPRVPKGAAPGSQTG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KKQQSTALQASTLAPANLLPKAVHLANLNLVPHSVAASVTAKSSVQRRSQPQLTQMSVPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKQQSTALQASTLAPANLLPKAVHLANLNLVPHSVAASVTAKSSVQRRSQPQLTQMSVPL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD VHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGYCCLECGDAFALEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGYCCLECGDAFALEK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD SLSQHYGRRSVHIEVLCTLCSKTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLSQHYGRRSVHIEVLCTLCSKTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD MFVSAPVNSTAPAAPAPSSSPKHGLTSGSASPPPPALPLYPDPVRLIRYSIKCLECHKQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MFVSAPVNSTAPAAPAPSSSPKHGLTSGSASPPPPALPLYPDPVRLIRYSIKCLECHKQM 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD RDYMVLAAHFQRTTEETEGLTCQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGVLCRSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDYMVLAAHFQRTTEETEGLTCQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGVLCRSA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD YFQTHVKENCLHYARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YFQTHVKENCLHYARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTAS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD STADHSATQHPTQPHRPSQLIYKCSCEMVFNKKRHIQQHFYQNVSKTQVGVFKCPECPLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STADHSATQHPTQPHRPSQLIYKCSCEMVFNKKRHIQQHFYQNVSKTQVGVFKCPECPLL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD FVQKPELMQHVKSTHGVPRNVDELSNLQSSADTSSSRPGSRVPTEPPATSVAARSSSLPS :::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::: XP_011 FVQKPELMQHVKSTHGVPRNVDELSSLQSSADTSSSRPGSRVPTEPPATSVAARSSSLPS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD GRWGRPEAHRRVEARPRLRNTGWTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQCEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRWGRPEAHRRVEARPRLRNTGWTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQCEQ 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD SFHTPNSLRKHIRNNHDTVKKFYTCGYCTEDSPSFPRPSLLESHISLMHGIRNPDLSQTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SFHTPNSLRKHIRNNHDTVKKFYTCGYCTEDSPSFPRPSLLESHISLMHGIRNPDLSQTS 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD KVKPPGGHSPQVNHLKRPVSGVGDAPGTSNGATVSSTKRHKSLFQCAKCSFATDSGLEFQ ::::::::::: XP_011 KVKPPGGHSPQA 1090 >>XP_011508113 (OMIM: 610568,616833) PREDICTED: zinc fin (1178 aa) initn: 1798 init1: 546 opt: 754 Z-score: 338.1 bits: 74.6 E(85289): 4.3e-12 Smith-Waterman score: 1842; 34.0% identity (56.0% similar) in 1254 aa overlap (1-1179:1-1102) 10 20 30 40 50 pF1KSD MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKP----PGICMD-ESVSLS :::::::::::::::::::: .::.:::.. ::::.: : ::. . :... . XP_011 MGDMKTPDFDDLLAAFDIPD---IDANEAIHSGPEENEGPGGPGKPEPGVGSESEDTAAA 10 20 30 40 50 60 70 80 90 100 pF1KSD HSGSAPDVPA--------------VSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLP .:..: ::: :::::::: :. :: . . . . .. : XP_011 SAGDGPGVPAQASDHGLPPPDISVVSVIVKNTVCPEQSEALAGGSAGDGAQAAGVTKEGP 60 70 80 90 100 110 110 120 130 140 150 160 pF1KSD PDPHNCGKFDSTFMNGDSARSFPGKLEPPKSEPLPTFNQFSPISSPEPEDPIKDNGFGIK :: .... : :. :.:: . : :... . . . : : . :: . XP_011 VGPH---RMQNGF--GSPEPSLPGTPHSPAPPSGGTWKE-KGMEGKTPLDLFAH--FGPE 120 130 140 150 160 170 180 190 200 210 pF1KSD P-KHSDSYFPPPLGCGAVGGPVLE-ALAKFPVP---ELHMFDHFCKKEPKPEPLPLGSQQ : ::: .:: .. .:. : ::. : : :: . . . : : :::. . XP_011 PGDHSDP-LPP-----SAPSPTREGALTPPPFPSSFELAQENGPGMQPPVSSP-PLGALK 170 180 190 200 210 220 220 230 240 250 260 270 pF1KSD EHEQSGQNTVEPHKDPDATRFFGEALEFNSHPSNSIGESKGLARELGTCSSVPPRQRLKP :.. ::. :.. : . : :. : .. . .: :: . : XP_011 ------QESCSPHH-PQVLAQQGSG----SSPK---------ATDIPASASPPPVAGV-P 230 240 250 260 280 290 300 310 320 330 pF1KSD AHSKLSSCVAALVALQAKRVASVTKEDQPGHTKDLSGPTKESSKGSPKMPKSPKSPRSPL .. . . :.. .. . .:: : ::. .:: : ::.:: : XP_011 FFKQSPGHQSPLASPKVPVCQPLKEED------DDEGPVDKSS------PGSPQSPSSGA 270 280 290 300 340 350 360 370 380 390 pF1KSD EATRKSIKPSDSPRSICSDSSSKGSPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILP :: .: .:. ::. ..: : :::::::::: :.: ::::.. XP_011 EA---------------ADEDSNDSPASSSSRPL---KVRIKTIKTSCGNITRTVTQVPS 310 320 330 340 350 400 410 420 430 440 450 pF1KSD DPDDPSKSPVGSPLGSAIAEAPSEMPGDEVPVEEHFPEAGTNSGSPQGAR-KGDESMTKA ::: :. :.. :. .::: . .:. : .... :. :.: :: . . XP_011 DPDPPA--PLAE--GAFLAEASLLKLSPATPTSEGPKVVSVQLGD--GTRLKGTVLPVAT 360 370 380 390 400 460 470 480 490 500 510 pF1KSD SDSSSPSCSSGPRVPKGAA--PGSQTGKKQQSTALQASTLAPANLLPKAVHLANLNLVPH ...: . . : . :. ::. :. . . : .. :.: . :::: :.:. . XP_011 IQNASTAMLMAASVARKAVVLPGG-TATSPKMIAKNVLGLVP-QALPKADGRAGLGTGGQ 410 420 430 440 450 460 520 530 540 550 560 570 pF1KSD SV-AASVTAKSSVQRRSQPQLTQMSVPLVHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNL .: .:::. . . . :. .: .... .::.:::.:.:.: .: : ::: XP_011 KVNGASVVMVQPSKTATGPSTGGGTV-----ISRTQSSLVEAFNKILNSKNLLPAYRPNL 470 480 490 500 510 580 590 600 610 620 630 pF1KSD SPPADSRIHVPASGYCCLECGDAFALEKSLSQHYGRRSVHIEVLCTLCSKTLLFFNKCSL ::::.. . .: .:: ::::::::.:::::..:: :::..::: :. :.. :.::::::: XP_011 SPPAEAGLALPPTGYRCLECGDAFSLEKSLARHYDRRSMRIEVTCNHCARRLVFFNKCSL 520 530 540 550 560 570 640 650 660 670 680 pF1KSD LRHARDHKSKGLVMQCSQLLVKPISADQMFVSAPVNSTAPAAPAPSSSP--------KHG : :::.::.::::::::.:...:.. ::: . .. :.: : :.: .: XP_011 LLHAREHKDKGLVMQCSHLVMRPVALDQMVGQPDITPLLPVAVPPVSGPLALPALGKGEG 580 590 600 610 620 630 690 700 710 720 730 pF1KSD LTSGSA----SPPPPALPLYPDPVRLIRYS----IKCLECHKQMRDYMVLAAHFQRTTEE ..:: . :.::: .: : ..::::..: :: .:::::. XP_011 AITSSAITTVAAEAPVLPLSTEPPAAPATSAYTCFRCLECKEQCRDKAGMAAHFQQLGPP 640 650 660 670 680 690 740 750 760 770 780 790 pF1KSD TEGLT---CQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGVLCRSAYFQTHVKENCLHY . : : : .: :.:::.::: ::::.: .. :. ::::: .: ::::..: ::: XP_011 APGATSNVCPTCPMMLPNRCSFSAHQRMHKNRPPHVCPECGGNFLQANFQTHLREACLHV 700 710 720 730 740 750 800 810 820 830 840 850 pF1KSD ARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTASSTADHSATQHPTQ .:.:::: XP_011 SRRVGYR----------------------------------------------------- 760 860 870 880 890 900 910 pF1KSD PHRPSQLIYKCS-CEMVFNKKRHIQQHFYQNVSKTQVGVFKCPECPLLFVQKPELMQHVK :::::. :. ::..: ...:: :.. .:.::::: :::::.:: ...:.: XP_011 ------LIYKCAMCDTVFTHKPLLSSHFDQHLLPQRVSVFKCPSCPLLFAQKRTMLEHLK 770 780 790 800 810 920 930 940 950 960 pF1KSD STHGVPRNVDELSNLQSSAD--TSSSRPGSRVPTE---PPATSVAARSSS---LPSG-RW .:: : ..: .. ... : ...: . .. ::: .. :: .::. . XP_011 NTHQSGR-LEETAGKGAGGALLTPKTEPEELAVSQGGAAPATEESSSSSEEEEVPSSPEP 820 830 840 850 860 870 970 980 990 1000 1010 pF1KSD GRPEAHRRVEARPR-LRNTG-----WTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQ :: . : : . :.. : ::: :. : :.:. ::.:::: ::...:..::: XP_011 PRPAKRPRRELGSKGLKGGGGGPGGWTCGLCHSWFPERDEYVAHMKKEHGKSVKKFPCRL 880 890 900 910 920 930 1020 1030 1040 1050 1060 1070 pF1KSD CEQSFHTPNSLRKHIRNNHDTVKKFYTCGYCTEDSPSFPRPSLLESHISLMHGI------ ::.:: . :::.:.: ::. .:. : : :::: . .: .::.:... ::. XP_011 CERSFCSAPSLRRHVRVNHEGIKRVYPCRYCTEGKRTFSSRLILEKHVQVRHGLQLGAQS 940 950 960 970 980 990 1080 1090 1100 1110 1120 pF1KSD --RNPDLSQTS--KVKPPGGHSPQVNHL--KRPVSGVGDAPGTSNGATVSSTKRHKSLFQ :. :.. : ... :: . : . ..: : . : . .: .. : : XP_011 PGRGTTLARGSSARAQGPGRKRRQSSDSCSEEPDSTTPPAKSPRGG---PGSGGHGPL-- 1000 1010 1020 1030 1040 1050 1130 1140 1150 1160 1170 1180 pF1KSD CAKCSFATDSGLEFQSHIPQHQVDSSTAQCLLCGLCYTSASSLSRHLFIVHKVRDQEEEE . ..:. : :: . .:.... ::: ::::..: .::::: :: :: : XP_011 ----RYRSSSSTE-QSLMMGLRVEDGAQQCLDCGLCFASPGSLSRHRFISHKKRRGVGKA 1060 1070 1080 1090 1100 1190 1200 1210 1220 1230 1240 pF1KSD EEEAAAAEMAVEVAEPEEGSGEEVPMETRENGLEECAGEPLSADPEARRLLGPAPEDDGG XP_011 SALGLGDGEEEAPPSRSDPDGGDSPLPASGGPLTCKVCGKSCDSPLNLKTHFRTHGMAFI 1110 1120 1130 1140 1150 1160 >>XP_011508114 (OMIM: 610568,616833) PREDICTED: zinc fin (1237 aa) initn: 2075 init1: 519 opt: 641 Z-score: 290.7 bits: 65.9 E(85289): 1.9e-09 Smith-Waterman score: 2174; 36.1% identity (59.2% similar) in 1254 aa overlap (1-1179:1-1161) 10 20 30 40 50 pF1KSD MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKP----PGICMD-ESVSLS :::::::::::::::::::: .::.:::.. ::::.: : ::. . :... . XP_011 MGDMKTPDFDDLLAAFDIPD---IDANEAIHSGPEENEGPGGPGKPEPGVGSESEDTAAA 10 20 30 40 50 60 70 80 90 100 pF1KSD HSGSAPDVPA--------------VSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLP .:..: ::: :::::::: :. :: . . . . .. : XP_011 SAGDGPGVPAQASDHGLPPPDISVVSVIVKNTVCPEQSEALAGGSAGDGAQAAGVTKEGP 60 70 80 90 100 110 110 120 130 140 150 160 pF1KSD PDPHNCGKFDSTFMNGDSARSFPGKLEPPKSEPLPTFNQFSPISSPEPEDPIKDNGFGIK :: .... : :. :.:: . : :... . . . : : . :: . XP_011 VGPH---RMQNGF--GSPEPSLPGTPHSPAPPSGGTWKE-KGMEGKTPLDLFAH--FGPE 120 130 140 150 160 170 180 190 200 210 pF1KSD P-KHSDSYFPPPLGCGAVGGPVLE-ALAKFPVP---ELHMFDHFCKKEPKPEPLPLGSQQ : ::: .:: .. .:. : ::. : : :: . . . : : :::. . XP_011 PGDHSDP-LPP-----SAPSPTREGALTPPPFPSSFELAQENGPGMQPPVSSP-PLGALK 170 180 190 200 210 220 220 230 240 250 260 270 pF1KSD EHEQSGQNTVEPHKDPDATRFFGEALEFNSHPSNSIGESKGLARELGTCSSVPPRQRLKP :.. ::. :.. : . : :. : .. . .: :: . : XP_011 ------QESCSPHH-PQVLAQQGSG----SSPK---------ATDIPASASPPPVAGV-P 230 240 250 260 280 290 300 310 320 330 pF1KSD AHSKLSSCVAALVALQAKRVASVTKEDQPGHTKDLSGPTKESSKGSPKMPKSPKSPRSPL .. . . :.. .. . .:: : ::. .:: : ::.:: : XP_011 FFKQSPGHQSPLASPKVPVCQPLKEED------DDEGPVDKSS------PGSPQSPSSGA 270 280 290 300 340 350 360 370 380 390 pF1KSD EATRKSIKPSDSPRSICSDSSSKGSPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILP :: .: .:. ::. ..: : :::::::::: :.: ::::.. XP_011 EA---------------ADEDSNDSPASSSSRPL---KVRIKTIKTSCGNITRTVTQVPS 310 320 330 340 350 400 410 420 430 440 450 pF1KSD DPDDPSKSPVGSPLGSAIAEAPSEMPGDEVPVEEHFPEAGTNSGSPQGAR-KGDESMTKA ::: :. :.. :. .::: . .:. : .... :. :.: :: . . XP_011 DPDPPA--PLAE--GAFLAEASLLKLSPATPTSEGPKVVSVQLGD--GTRLKGTVLPVAT 360 370 380 390 400 460 470 480 490 500 510 pF1KSD SDSSSPSCSSGPRVPKGAA--PGSQTGKKQQSTALQASTLAPANLLPKAVHLANLNLVPH ...: . . : . :. ::. :. . . : .. :.: . :::: :.:. . XP_011 IQNASTAMLMAASVARKAVVLPGG-TATSPKMIAKNVLGLVP-QALPKADGRAGLGTGGQ 410 420 430 440 450 460 520 530 540 550 560 570 pF1KSD SV-AASVTAKSSVQRRSQPQLTQMSVPLVHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNL .: .:::. . . . :. .: .... .::.:::.:.:.: .: : ::: XP_011 KVNGASVVMVQPSKTATGPSTGGGTV-----ISRTQSSLVEAFNKILNSKNLLPAYRPNL 470 480 490 500 510 580 590 600 610 620 630 pF1KSD SPPADSRIHVPASGYCCLECGDAFALEKSLSQHYGRRSVHIEVLCTLCSKTLLFFNKCSL ::::.. . .: .:: ::::::::.:::::..:: :::..::: :. :.. :.::::::: XP_011 SPPAEAGLALPPTGYRCLECGDAFSLEKSLARHYDRRSMRIEVTCNHCARRLVFFNKCSL 520 530 540 550 560 570 640 650 660 670 680 pF1KSD LRHARDHKSKGLVMQCSQLLVKPISADQMFVSAPVNSTAPAAPAPSSSP--------KHG : :::.::.::::::::.:...:.. ::: . .. :.: : :.: .: XP_011 LLHAREHKDKGLVMQCSHLVMRPVALDQMVGQPDITPLLPVAVPPVSGPLALPALGKGEG 580 590 600 610 620 630 690 700 710 720 730 pF1KSD LTSGSA----SPPPPALPLYPDPVRLIRYS----IKCLECHKQMRDYMVLAAHFQRTTEE ..:: . :.::: .: : ..::::..: :: .:::::. XP_011 AITSSAITTVAAEAPVLPLSTEPPAAPATSAYTCFRCLECKEQCRDKAGMAAHFQQLGPP 640 650 660 670 680 690 740 750 760 770 780 790 pF1KSD TEGLT---CQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGVLCRSAYFQTHVKENCLHY . : : : .: :.:::.::: ::::.: .. :. ::::: .: ::::..: ::: XP_011 APGATSNVCPTCPMMLPNRCSFSAHQRMHKNRPPHVCPECGGNFLQANFQTHLREACLHV 700 710 720 730 740 750 800 810 820 830 840 850 pF1KSD ARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTASSTADHSATQHPTQ .:.::::: :.:: . .::::: ::.::::: .::::::.. :. : .:::. XP_011 SRRVGYRCPSCSVVFGGVNSIKSHIQTSHCEVFHKCPICPMAFKSGPSAHAHLYSQHPSF 760 770 780 790 800 810 860 870 880 890 900 910 pF1KSD PHRPSQLIYKCS-CEMVFNKKRHIQQHFYQNVSKTQVGVFKCPECPLLFVQKPELMQHVK . ..:::::. :. ::..: ...:: :.. .:.::::: :::::.:: ...:.: XP_011 QTQQAKLIYKCAMCDTVFTHKPLLSSHFDQHLLPQRVSVFKCPSCPLLFAQKRTMLEHLK 820 830 840 850 860 870 920 930 940 950 960 pF1KSD STHGVPRNVDELSNLQSSAD--TSSSRPGSRVPTE---PPATSVAARSSS---LPSG-RW .:: : ..: .. ... : ...: . .. ::: .. :: .::. . XP_011 NTHQSGR-LEETAGKGAGGALLTPKTEPEELAVSQGGAAPATEESSSSSEEEEVPSSPEP 880 890 900 910 920 930 970 980 990 1000 1010 pF1KSD GRPEAHRRVEARPR-LRNTG-----WTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQ :: . : : . :.. : ::: :. : :.:. ::.:::: ::...:..::: XP_011 PRPAKRPRRELGSKGLKGGGGGPGGWTCGLCHSWFPERDEYVAHMKKEHGKSVKKFPCRL 940 950 960 970 980 990 1020 1030 1040 1050 1060 1070 pF1KSD CEQSFHTPNSLRKHIRNNHDTVKKFYTCGYCTEDSPSFPRPSLLESHISLMHGI------ ::.:: . :::.:.: ::. .:. : : :::: . .: .::.:... ::. XP_011 CERSFCSAPSLRRHVRVNHEGIKRVYPCRYCTEGKRTFSSRLILEKHVQVRHGLQLGAQS 1000 1010 1020 1030 1040 1050 1080 1090 1100 1110 1120 pF1KSD --RNPDLSQTS--KVKPPGGHSPQVNHL--KRPVSGVGDAPGTSNGATVSSTKRHKSLFQ :. :.. : ... :: . : . ..: : . : . .: .. : : XP_011 PGRGTTLARGSSARAQGPGRKRRQSSDSCSEEPDSTTPPAKSPRGG---PGSGGHGPL-- 1060 1070 1080 1090 1100 1110 1130 1140 1150 1160 1170 1180 pF1KSD CAKCSFATDSGLEFQSHIPQHQVDSSTAQCLLCGLCYTSASSLSRHLFIVHKVRDQEEEE . ..:. : :: . .:.... ::: ::::..: .::::: :: :: : XP_011 ----RYRSSSSTE-QSLMMGLRVEDGAQQCLDCGLCFASPGSLSRHRFISHKKRRGVGKA 1120 1130 1140 1150 1160 1190 1200 1210 1220 1230 1240 pF1KSD EEEAAAAEMAVEVAEPEEGSGEEVPMETRENGLEECAGEPLSADPEARRLLGPAPEDDGG XP_011 SALGLGDGEEEAPPSRSDPDGGDSPLPASGGPLTCKVCGKSCDSPLNLKTHFRTHGMAFI 1170 1180 1190 1200 1210 1220 >>NP_001291692 (OMIM: 610568,616833) zinc finger protein (1237 aa) initn: 2075 init1: 519 opt: 641 Z-score: 290.7 bits: 65.9 E(85289): 1.9e-09 Smith-Waterman score: 2174; 36.1% identity (59.2% similar) in 1254 aa overlap (1-1179:1-1161) 10 20 30 40 50 pF1KSD MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKP----PGICMD-ESVSLS :::::::::::::::::::: .::.:::.. ::::.: : ::. . :... . NP_001 MGDMKTPDFDDLLAAFDIPD---IDANEAIHSGPEENEGPGGPGKPEPGVGSESEDTAAA 10 20 30 40 50 60 70 80 90 100 pF1KSD HSGSAPDVPA--------------VSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLP .:..: ::: :::::::: :. :: . . . . .. : NP_001 SAGDGPGVPAQASDHGLPPPDISVVSVIVKNTVCPEQSEALAGGSAGDGAQAAGVTKEGP 60 70 80 90 100 110 110 120 130 140 150 160 pF1KSD PDPHNCGKFDSTFMNGDSARSFPGKLEPPKSEPLPTFNQFSPISSPEPEDPIKDNGFGIK :: .... : :. :.:: . : :... . . . : : . :: . NP_001 VGPH---RMQNGF--GSPEPSLPGTPHSPAPPSGGTWKE-KGMEGKTPLDLFAH--FGPE 120 130 140 150 160 170 180 190 200 210 pF1KSD P-KHSDSYFPPPLGCGAVGGPVLE-ALAKFPVP---ELHMFDHFCKKEPKPEPLPLGSQQ : ::: .:: .. .:. : ::. : : :: . . . : : :::. . NP_001 PGDHSDP-LPP-----SAPSPTREGALTPPPFPSSFELAQENGPGMQPPVSSP-PLGALK 170 180 190 200 210 220 220 230 240 250 260 270 pF1KSD EHEQSGQNTVEPHKDPDATRFFGEALEFNSHPSNSIGESKGLARELGTCSSVPPRQRLKP :.. ::. :.. : . : :. : .. . .: :: . : NP_001 ------QESCSPHH-PQVLAQQGSG----SSPK---------ATDIPASASPPPVAGV-P 230 240 250 260 280 290 300 310 320 330 pF1KSD AHSKLSSCVAALVALQAKRVASVTKEDQPGHTKDLSGPTKESSKGSPKMPKSPKSPRSPL .. . . :.. .. . .:: : ::. .:: : ::.:: : NP_001 FFKQSPGHQSPLASPKVPVCQPLKEED------DDEGPVDKSS------PGSPQSPSSGA 270 280 290 300 340 350 360 370 380 390 pF1KSD EATRKSIKPSDSPRSICSDSSSKGSPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILP :: .: .:. ::. ..: : :::::::::: :.: ::::.. NP_001 EA---------------ADEDSNDSPASSSSRPL---KVRIKTIKTSCGNITRTVTQVPS 310 320 330 340 350 400 410 420 430 440 450 pF1KSD DPDDPSKSPVGSPLGSAIAEAPSEMPGDEVPVEEHFPEAGTNSGSPQGAR-KGDESMTKA ::: :. :.. :. .::: . .:. : .... :. :.: :: . . NP_001 DPDPPA--PLAE--GAFLAEASLLKLSPATPTSEGPKVVSVQLGD--GTRLKGTVLPVAT 360 370 380 390 400 460 470 480 490 500 510 pF1KSD SDSSSPSCSSGPRVPKGAA--PGSQTGKKQQSTALQASTLAPANLLPKAVHLANLNLVPH ...: . . : . :. ::. :. . . : .. :.: . :::: :.:. . NP_001 IQNASTAMLMAASVARKAVVLPGG-TATSPKMIAKNVLGLVP-QALPKADGRAGLGTGGQ 410 420 430 440 450 460 520 530 540 550 560 570 pF1KSD SV-AASVTAKSSVQRRSQPQLTQMSVPLVHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNL .: .:::. . . . :. .: .... .::.:::.:.:.: .: : ::: NP_001 KVNGASVVMVQPSKTATGPSTGGGTV-----ISRTQSSLVEAFNKILNSKNLLPAYRPNL 470 480 490 500 510 580 590 600 610 620 630 pF1KSD SPPADSRIHVPASGYCCLECGDAFALEKSLSQHYGRRSVHIEVLCTLCSKTLLFFNKCSL ::::.. . .: .:: ::::::::.:::::..:: :::..::: :. :.. :.::::::: NP_001 SPPAEAGLALPPTGYRCLECGDAFSLEKSLARHYDRRSMRIEVTCNHCARRLVFFNKCSL 520 530 540 550 560 570 640 650 660 670 680 pF1KSD LRHARDHKSKGLVMQCSQLLVKPISADQMFVSAPVNSTAPAAPAPSSSP--------KHG : :::.::.::::::::.:...:.. ::: . .. :.: : :.: .: NP_001 LLHAREHKDKGLVMQCSHLVMRPVALDQMVGQPDITPLLPVAVPPVSGPLALPALGKGEG 580 590 600 610 620 630 690 700 710 720 730 pF1KSD LTSGSA----SPPPPALPLYPDPVRLIRYS----IKCLECHKQMRDYMVLAAHFQRTTEE ..:: . :.::: .: : ..::::..: :: .:::::. NP_001 AITSSAITTVAAEAPVLPLSTEPPAAPATSAYTCFRCLECKEQCRDKAGMAAHFQQLGPP 640 650 660 670 680 690 740 750 760 770 780 790 pF1KSD TEGLT---CQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGVLCRSAYFQTHVKENCLHY . : : : .: :.:::.::: ::::.: .. :. ::::: .: ::::..: ::: NP_001 APGATSNVCPTCPMMLPNRCSFSAHQRMHKNRPPHVCPECGGNFLQANFQTHLREACLHV 700 710 720 730 740 750 800 810 820 830 840 850 pF1KSD ARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTASSTADHSATQHPTQ .:.::::: :.:: . .::::: ::.::::: .::::::.. :. : .:::. NP_001 SRRVGYRCPSCSVVFGGVNSIKSHIQTSHCEVFHKCPICPMAFKSGPSAHAHLYSQHPSF 760 770 780 790 800 810 860 870 880 890 900 910 pF1KSD PHRPSQLIYKCS-CEMVFNKKRHIQQHFYQNVSKTQVGVFKCPECPLLFVQKPELMQHVK . ..:::::. :. ::..: ...:: :.. .:.::::: :::::.:: ...:.: NP_001 QTQQAKLIYKCAMCDTVFTHKPLLSSHFDQHLLPQRVSVFKCPSCPLLFAQKRTMLEHLK 820 830 840 850 860 870 920 930 940 950 960 pF1KSD STHGVPRNVDELSNLQSSAD--TSSSRPGSRVPTE---PPATSVAARSSS---LPSG-RW .:: : ..: .. ... : ...: . .. ::: .. :: .::. . NP_001 NTHQSGR-LEETAGKGAGGALLTPKTEPEELAVSQGGAAPATEESSSSSEEEEVPSSPEP 880 890 900 910 920 930 970 980 990 1000 1010 pF1KSD GRPEAHRRVEARPR-LRNTG-----WTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQ :: . : : . :.. : ::: :. : :.:. ::.:::: ::...:..::: NP_001 PRPAKRPRRELGSKGLKGGGGGPGGWTCGLCHSWFPERDEYVAHMKKEHGKSVKKFPCRL 940 950 960 970 980 990 1020 1030 1040 1050 1060 1070 pF1KSD CEQSFHTPNSLRKHIRNNHDTVKKFYTCGYCTEDSPSFPRPSLLESHISLMHGI------ ::.:: . :::.:.: ::. .:. : : :::: . .: .::.:... ::. NP_001 CERSFCSAPSLRRHVRVNHEGIKRVYPCRYCTEGKRTFSSRLILEKHVQVRHGLQLGAQS 1000 1010 1020 1030 1040 1050 1080 1090 1100 1110 1120 pF1KSD --RNPDLSQTS--KVKPPGGHSPQVNHL--KRPVSGVGDAPGTSNGATVSSTKRHKSLFQ :. :.. : ... :: . : . ..: : . : . .: .. : : NP_001 PGRGTTLARGSSARAQGPGRKRRQSSDSCSEEPDSTTPPAKSPRGG---PGSGGHGPL-- 1060 1070 1080 1090 1100 1110 1130 1140 1150 1160 1170 1180 pF1KSD CAKCSFATDSGLEFQSHIPQHQVDSSTAQCLLCGLCYTSASSLSRHLFIVHKVRDQEEEE . ..:. : :: . .:.... ::: ::::..: .::::: :: :: : NP_001 ----RYRSSSSTE-QSLMMGLRVEDGAQQCLDCGLCFASPGSLSRHRFISHKKRRGVGKA 1120 1130 1140 1150 1160 1190 1200 1210 1220 1230 1240 pF1KSD EEEAAAAEMAVEVAEPEEGSGEEVPMETRENGLEECAGEPLSADPEARRLLGPAPEDDGG NP_001 SALGLGDGEEEAPPSRSDPDGGDSPLPASGGPLTCKVCGKSCDSPLNLKTHFRTHGMAFI 1170 1180 1190 1200 1210 1220 >>NP_065883 (OMIM: 610568,616833) zinc finger protein 68 (1237 aa) initn: 2075 init1: 519 opt: 641 Z-score: 290.7 bits: 65.9 E(85289): 1.9e-09 Smith-Waterman score: 2174; 36.1% identity (59.2% similar) in 1254 aa overlap (1-1179:1-1161) 10 20 30 40 50 pF1KSD MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKP----PGICMD-ESVSLS :::::::::::::::::::: .::.:::.. ::::.: : ::. . :... . NP_065 MGDMKTPDFDDLLAAFDIPD---IDANEAIHSGPEENEGPGGPGKPEPGVGSESEDTAAA 10 20 30 40 50 60 70 80 90 100 pF1KSD HSGSAPDVPA--------------VSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLP .:..: ::: :::::::: :. :: . . . . .. : NP_065 SAGDGPGVPAQASDHGLPPPDISVVSVIVKNTVCPEQSEALAGGSAGDGAQAAGVTKEGP 60 70 80 90 100 110 110 120 130 140 150 160 pF1KSD PDPHNCGKFDSTFMNGDSARSFPGKLEPPKSEPLPTFNQFSPISSPEPEDPIKDNGFGIK :: .... : :. :.:: . : :... . . . : : . :: . NP_065 VGPH---RMQNGF--GSPEPSLPGTPHSPAPPSGGTWKE-KGMEGKTPLDLFAH--FGPE 120 130 140 150 160 170 180 190 200 210 pF1KSD P-KHSDSYFPPPLGCGAVGGPVLE-ALAKFPVP---ELHMFDHFCKKEPKPEPLPLGSQQ : ::: .:: .. .:. : ::. : : :: . . . : : :::. . NP_065 PGDHSDP-LPP-----SAPSPTREGALTPPPFPSSFELAQENGPGMQPPVSSP-PLGALK 170 180 190 200 210 220 220 230 240 250 260 270 pF1KSD EHEQSGQNTVEPHKDPDATRFFGEALEFNSHPSNSIGESKGLARELGTCSSVPPRQRLKP :.. ::. :.. : . : :. : .. . .: :: . : NP_065 ------QESCSPHH-PQVLAQQGSG----SSPK---------ATDIPASASPPPVAGV-P 230 240 250 260 280 290 300 310 320 330 pF1KSD AHSKLSSCVAALVALQAKRVASVTKEDQPGHTKDLSGPTKESSKGSPKMPKSPKSPRSPL .. . . :.. .. . .:: : ::. .:: : ::.:: : NP_065 FFKQSPGHQSPLASPKVPVCQPLKEED------DDEGPVDKSS------PGSPQSPSSGA 270 280 290 300 340 350 360 370 380 390 pF1KSD EATRKSIKPSDSPRSICSDSSSKGSPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILP :: .: .:. ::. ..: : :::::::::: :.: ::::.. NP_065 EA---------------ADEDSNDSPASSSSRPL---KVRIKTIKTSCGNITRTVTQVPS 310 320 330 340 350 400 410 420 430 440 450 pF1KSD DPDDPSKSPVGSPLGSAIAEAPSEMPGDEVPVEEHFPEAGTNSGSPQGAR-KGDESMTKA ::: :. :.. :. .::: . .:. : .... :. :.: :: . . NP_065 DPDPPA--PLAE--GAFLAEASLLKLSPATPTSEGPKVVSVQLGD--GTRLKGTVLPVAT 360 370 380 390 400 460 470 480 490 500 510 pF1KSD SDSSSPSCSSGPRVPKGAA--PGSQTGKKQQSTALQASTLAPANLLPKAVHLANLNLVPH ...: . . : . :. ::. :. . . : .. :.: . :::: :.:. . NP_065 IQNASTAMLMAASVARKAVVLPGG-TATSPKMIAKNVLGLVP-QALPKADGRAGLGTGGQ 410 420 430 440 450 460 520 530 540 550 560 570 pF1KSD SV-AASVTAKSSVQRRSQPQLTQMSVPLVHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNL .: .:::. . . . :. .: .... .::.:::.:.:.: .: : ::: NP_065 KVNGASVVMVQPSKTATGPSTGGGTV-----ISRTQSSLVEAFNKILNSKNLLPAYRPNL 470 480 490 500 510 580 590 600 610 620 630 pF1KSD SPPADSRIHVPASGYCCLECGDAFALEKSLSQHYGRRSVHIEVLCTLCSKTLLFFNKCSL ::::.. . .: .:: ::::::::.:::::..:: :::..::: :. :.. :.::::::: NP_065 SPPAEAGLALPPTGYRCLECGDAFSLEKSLARHYDRRSMRIEVTCNHCARRLVFFNKCSL 520 530 540 550 560 570 640 650 660 670 680 pF1KSD LRHARDHKSKGLVMQCSQLLVKPISADQMFVSAPVNSTAPAAPAPSSSP--------KHG : :::.::.::::::::.:...:.. ::: . .. :.: : :.: .: NP_065 LLHAREHKDKGLVMQCSHLVMRPVALDQMVGQPDITPLLPVAVPPVSGPLALPALGKGEG 580 590 600 610 620 630 690 700 710 720 730 pF1KSD LTSGSA----SPPPPALPLYPDPVRLIRYS----IKCLECHKQMRDYMVLAAHFQRTTEE ..:: . :.::: .: : ..::::..: :: .:::::. NP_065 AITSSAITTVAAEAPVLPLSTEPPAAPATSAYTCFRCLECKEQCRDKAGMAAHFQQLGPP 640 650 660 670 680 690 740 750 760 770 780 790 pF1KSD TEGLT---CQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGVLCRSAYFQTHVKENCLHY . : : : .: :.:::.::: ::::.: .. :. ::::: .: ::::..: ::: NP_065 APGATSNVCPTCPMMLPNRCSFSAHQRMHKNRPPHVCPECGGNFLQANFQTHLREACLHV 700 710 720 730 740 750 800 810 820 830 840 850 pF1KSD ARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTASSTADHSATQHPTQ .:.::::: :.:: . .::::: ::.::::: .::::::.. :. : .:::. NP_065 SRRVGYRCPSCSVVFGGVNSIKSHIQTSHCEVFHKCPICPMAFKSGPSAHAHLYSQHPSF 760 770 780 790 800 810 860 870 880 890 900 910 pF1KSD PHRPSQLIYKCS-CEMVFNKKRHIQQHFYQNVSKTQVGVFKCPECPLLFVQKPELMQHVK . ..:::::. :. ::..: ...:: :.. .:.::::: :::::.:: ...:.: NP_065 QTQQAKLIYKCAMCDTVFTHKPLLSSHFDQHLLPQRVSVFKCPSCPLLFAQKRTMLEHLK 820 830 840 850 860 870 920 930 940 950 960 pF1KSD STHGVPRNVDELSNLQSSAD--TSSSRPGSRVPTE---PPATSVAARSSS---LPSG-RW .:: : ..: .. ... : ...: . .. ::: .. :: .::. . NP_065 NTHQSGR-LEETAGKGAGGALLTPKTEPEELAVSQGGAAPATEESSSSSEEEEVPSSPEP 880 890 900 910 920 930 970 980 990 1000 1010 pF1KSD GRPEAHRRVEARPR-LRNTG-----WTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQ :: . : : . :.. : ::: :. : :.:. ::.:::: ::...:..::: NP_065 PRPAKRPRRELGSKGLKGGGGGPGGWTCGLCHSWFPERDEYVAHMKKEHGKSVKKFPCRL 940 950 960 970 980 990 1020 1030 1040 1050 1060 1070 pF1KSD CEQSFHTPNSLRKHIRNNHDTVKKFYTCGYCTEDSPSFPRPSLLESHISLMHGI------ ::.:: . :::.:.: ::. .:. : : :::: . .: .::.:... ::. NP_065 CERSFCSAPSLRRHVRVNHEGIKRVYPCRYCTEGKRTFSSRLILEKHVQVRHGLQLGAQS 1000 1010 1020 1030 1040 1050 1080 1090 1100 1110 1120 pF1KSD --RNPDLSQTS--KVKPPGGHSPQVNHL--KRPVSGVGDAPGTSNGATVSSTKRHKSLFQ :. :.. : ... :: . : . ..: : . : . .: .. : : NP_065 PGRGTTLARGSSARAQGPGRKRRQSSDSCSEEPDSTTPPAKSPRGG---PGSGGHGPL-- 1060 1070 1080 1090 1100 1110 1130 1140 1150 1160 1170 1180 pF1KSD CAKCSFATDSGLEFQSHIPQHQVDSSTAQCLLCGLCYTSASSLSRHLFIVHKVRDQEEEE . ..:. : :: . .:.... ::: ::::..: .::::: :: :: : NP_065 ----RYRSSSSTE-QSLMMGLRVEDGAQQCLDCGLCFASPGSLSRHRFISHKKRRGVGKA 1120 1130 1140 1150 1160 1190 1200 1210 1220 1230 1240 pF1KSD EEEAAAAEMAVEVAEPEEGSGEEVPMETRENGLEECAGEPLSADPEARRLLGPAPEDDGG NP_065 SALGLGDGEEEAPPSRSDPDGGDSPLPASGGPLTCKVCGKSCDSPLNLKTHFRTHGMAFI 1170 1180 1190 1200 1210 1220 1267 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 00:41:44 2016 done: Thu Nov 3 00:41:46 2016 Total Scan time: 12.120 Total Display time: 0.580 Function used was FASTA [36.3.4 Apr, 2011]