FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0251, 788 aa 1>>>pF1KSDA0251 788 - 788 aa - 788 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.3954+/-0.000345; mu= 15.8630+/- 0.022 mean_var=100.1377+/-20.252, 0's: 0 Z-trim(116.2): 55 B-trim: 0 in 0/56 Lambda= 0.128167 statistics sampled from 27098 (27153) to 27098 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.679), E-opt: 0.2 (0.318), width: 16 Scan time: 12.950 The best scores are: opt bits E(85289) NP_055842 (OMIM: 614244) pyridoxal-dependent decar ( 788) 5203 973.0 0 NP_001310948 (OMIM: 614244) pyridoxal-dependent de ( 787) 5184 969.5 0 XP_016878549 (OMIM: 614244) PREDICTED: pyridoxal-d ( 797) 5169 966.7 0 XP_005255230 (OMIM: 614244) PREDICTED: pyridoxal-d ( 806) 5162 965.4 0 XP_016878548 (OMIM: 614244) PREDICTED: pyridoxal-d ( 773) 5112 956.1 0 XP_005255233 (OMIM: 614244) PREDICTED: pyridoxal-d ( 773) 5112 956.1 0 XP_016878550 (OMIM: 614244) PREDICTED: pyridoxal-d ( 773) 5112 956.1 0 NP_001272376 (OMIM: 614244) pyridoxal-dependent de ( 773) 5112 956.1 0 XP_016878551 (OMIM: 614244) PREDICTED: pyridoxal-d ( 773) 5112 956.1 0 XP_016878553 (OMIM: 614244) PREDICTED: pyridoxal-d ( 746) 4693 878.7 0 XP_006720928 (OMIM: 614244) PREDICTED: pyridoxal-d ( 746) 4693 878.7 0 NP_001272374 (OMIM: 614244) pyridoxal-dependent de ( 760) 4693 878.7 0 NP_001272373 (OMIM: 614244) pyridoxal-dependent de ( 761) 4693 878.7 0 XP_016878552 (OMIM: 614244) PREDICTED: pyridoxal-d ( 708) 4540 850.4 0 NP_001272377 (OMIM: 614244) pyridoxal-dependent de ( 697) 4365 818.0 0 NP_001272378 (OMIM: 614244) pyridoxal-dependent de ( 498) 3120 587.7 4.1e-167 NP_001310949 (OMIM: 614244) pyridoxal-dependent de ( 497) 3101 584.2 4.7e-166 XP_016878554 (OMIM: 614244) PREDICTED: pyridoxal-d ( 483) 3029 570.9 4.6e-162 NP_001310950 (OMIM: 614244) pyridoxal-dependent de ( 471) 2610 493.4 9.5e-139 NP_001272379 (OMIM: 614244) pyridoxal-dependent de ( 429) 1431 275.3 3.7e-73 >>NP_055842 (OMIM: 614244) pyridoxal-dependent decarboxy (788 aa) initn: 5203 init1: 5203 opt: 5203 Z-score: 5199.9 bits: 973.0 E(85289): 0 Smith-Waterman score: 5203; 100.0% identity (100.0% similar) in 788 aa overlap (1-788:1-788) 10 20 30 40 50 60 pF1KSD MDASLEKIADPTLAEMGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPLQGSGQDMVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MDASLEKIADPTLAEMGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPLQGSGQDMVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD ILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD TTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPVIYLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 TTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPVIYLSA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD AARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIERGRLPLLLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 AARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIERGRLPLLLVA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD NAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAAAKCDSMTMTPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 NAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAAAKCDSMTMTPG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD PWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLWLSLQYLGLDGFVERIKHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLWLSLQYLGLDGFVERIKHA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD CQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSDPVFKAVPVPNMTPSGVGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 CQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSDPVFKAVPVPNMTPSGVGR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD ERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPLMTAAVLGTRGEDVDQLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPLMTAAVLGTRGEDVDQLVA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD CIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGVVRYEHANDDKSSLKSDPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 CIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGVVRYEHANDDKSSLKSDPE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD GENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDNVDAAELVETIAATAREIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDNVDAAELVETIAATAREIE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD ENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIPVVGSVLNWFSPVQALQKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIPVVGSVLNWFSPVQALQKG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD RTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLPGQKPFKRSLRGSDALSET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLPGQKPFKRSLRGSDALSET 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD SSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQKGVPHPEDDHSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQKGVPHPEDDHSQ 730 740 750 760 770 780 pF1KSD VEGPESLR :::::::: NP_055 VEGPESLR >>NP_001310948 (OMIM: 614244) pyridoxal-dependent decarb (787 aa) initn: 5009 init1: 5009 opt: 5184 Z-score: 5180.9 bits: 969.5 E(85289): 0 Smith-Waterman score: 5184; 99.9% identity (99.9% similar) in 788 aa overlap (1-788:1-787) 10 20 30 40 50 60 pF1KSD MDASLEKIADPTLAEMGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPLQGSGQDMVS :::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::: NP_001 MDASLEKIADPTLAEMGKNLKEAVKMLEDSQR-TEEENGKKLISGDIPGPLQGSGQDMVS 10 20 30 40 50 70 80 90 100 110 120 pF1KSD ILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSD 60 70 80 90 100 110 130 140 150 160 170 180 pF1KSD TTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPVIYLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPVIYLSA 120 130 140 150 160 170 190 200 210 220 230 240 pF1KSD AARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIERGRLPLLLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIERGRLPLLLVA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KSD NAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAAAKCDSMTMTPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAAAKCDSMTMTPG 240 250 260 270 280 290 310 320 330 340 350 360 pF1KSD PWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLWLSLQYLGLDGFVERIKHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLWLSLQYLGLDGFVERIKHA 300 310 320 330 340 350 370 380 390 400 410 420 pF1KSD CQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSDPVFKAVPVPNMTPSGVGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSDPVFKAVPVPNMTPSGVGR 360 370 380 390 400 410 430 440 450 460 470 480 pF1KSD ERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPLMTAAVLGTRGEDVDQLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPLMTAAVLGTRGEDVDQLVA 420 430 440 450 460 470 490 500 510 520 530 540 pF1KSD CIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGVVRYEHANDDKSSLKSDPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGVVRYEHANDDKSSLKSDPE 480 490 500 510 520 530 550 560 570 580 590 600 pF1KSD GENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDNVDAAELVETIAATAREIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDNVDAAELVETIAATAREIE 540 550 560 570 580 590 610 620 630 640 650 660 pF1KSD ENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIPVVGSVLNWFSPVQALQKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIPVVGSVLNWFSPVQALQKG 600 610 620 630 640 650 670 680 690 700 710 720 pF1KSD RTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLPGQKPFKRSLRGSDALSET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLPGQKPFKRSLRGSDALSET 660 670 680 690 700 710 730 740 750 760 770 780 pF1KSD SSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQKGVPHPEDDHSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQKGVPHPEDDHSQ 720 730 740 750 760 770 pF1KSD VEGPESLR :::::::: NP_001 VEGPESLR 780 >>XP_016878549 (OMIM: 614244) PREDICTED: pyridoxal-depen (797 aa) initn: 5169 init1: 5169 opt: 5169 Z-score: 5165.8 bits: 966.7 E(85289): 0 Smith-Waterman score: 5169; 99.6% identity (99.7% similar) in 786 aa overlap (3-788:12-797) 10 20 30 40 50 pF1KSD MDASLEKIADPTLAEMGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPL :: . :::::::::::::::::::::::::::::::::::::::::::: XP_016 MLPERSRSYFRASCKPIADPTLAEMGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KSD QGSGQDMVSILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QGSGQDMVSILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLR 70 80 90 100 110 120 120 130 140 150 160 170 pF1KSD KLTTRILSDTTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLTTRILSDTTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYN 130 140 150 160 170 180 180 190 200 210 220 230 pF1KSD KKPVIYLSAAARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKPVIYLSAAARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIER 190 200 210 220 230 240 240 250 260 270 280 290 pF1KSD GRLPLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAAAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GRLPLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAAAK 250 260 270 280 290 300 300 310 320 330 340 350 pF1KSD CDSMTMTPGPWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLWLSLQYLGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CDSMTMTPGPWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLWLSLQYLGLD 310 320 330 340 350 360 360 370 380 390 400 410 pF1KSD GFVERIKHACQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSDPVFKAVPVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFVERIKHACQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSDPVFKAVPVP 370 380 390 400 410 420 420 430 440 450 460 470 pF1KSD NMTPSGVGRERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPLMTAAVLGTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NMTPSGVGRERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPLMTAAVLGTR 430 440 450 460 470 480 480 490 500 510 520 530 pF1KSD GEDVDQLVACIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGVVRYEHANDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GEDVDQLVACIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGVVRYEHANDD 490 500 510 520 530 540 540 550 560 570 580 590 pF1KSD KSSLKSDPEGENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDNVDAAELVET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSSLKSDPEGENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDNVDAAELVET 550 560 570 580 590 600 600 610 620 630 640 650 pF1KSD IAATAREIEENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIPVVGSVLNWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IAATAREIEENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIPVVGSVLNWF 610 620 630 640 650 660 660 670 680 690 700 710 pF1KSD SPVQALQKGRTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLPGQKPFKRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPVQALQKGRTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLPGQKPFKRSL 670 680 690 700 710 720 720 730 740 750 760 770 pF1KSD RGSDALSETSSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQKGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RGSDALSETSSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQKGV 730 740 750 760 770 780 780 pF1KSD PHPEDDHSQVEGPESLR ::::::::::::::::: XP_016 PHPEDDHSQVEGPESLR 790 >>XP_005255230 (OMIM: 614244) PREDICTED: pyridoxal-depen (806 aa) initn: 5162 init1: 5162 opt: 5162 Z-score: 5158.8 bits: 965.4 E(85289): 0 Smith-Waterman score: 5162; 99.9% identity (100.0% similar) in 782 aa overlap (7-788:25-806) 10 20 30 40 pF1KSD MDASLEKIADPTLAEMGKNLKEAVKMLEDSQRRTEEENGKKL .::::::::::::::::::::::::::::::::::: XP_005 MACSILEGCRREVRRETWKPGPGSEIADPTLAEMGKNLKEAVKMLEDSQRRTEEENGKKL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KSD ISGDIPGPLQGSGQDMVSILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ISGDIPGPLQGSGQDMVSILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYI 70 80 90 100 110 120 110 120 130 140 150 160 pF1KSD STLDKEKLRKLTTRILSDTTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 STLDKEKLRKLTTRILSDTTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFV 130 140 150 160 170 180 170 180 190 200 210 220 pF1KSD VDGFNVLYNKKPVIYLSAAARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VDGFNVLYNKKPVIYLSAAARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLE 190 200 210 220 230 240 230 240 250 260 270 280 pF1KSD KLIKDDIERGRLPLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KLIKDDIERGRLPLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYV 250 260 270 280 290 300 290 300 310 320 330 340 pF1KSD SSSVLAAAKCDSMTMTPGPWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSSVLAAAKCDSMTMTPGPWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLW 310 320 330 340 350 360 350 360 370 380 390 400 pF1KSD LSLQYLGLDGFVERIKHACQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSLQYLGLDGFVERIKHACQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSD 370 380 390 400 410 420 410 420 430 440 450 460 pF1KSD PVFKAVPVPNMTPSGVGRERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PVFKAVPVPNMTPSGVGRERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPL 430 440 450 460 470 480 470 480 490 500 510 520 pF1KSD MTAAVLGTRGEDVDQLVACIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MTAAVLGTRGEDVDQLVACIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGV 490 500 510 520 530 540 530 540 550 560 570 580 pF1KSD VRYEHANDDKSSLKSDPEGENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VRYEHANDDKSSLKSDPEGENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDN 550 560 570 580 590 600 590 600 610 620 630 640 pF1KSD VDAAELVETIAATAREIEENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VDAAELVETIAATAREIEENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIP 610 620 630 640 650 660 650 660 670 680 690 700 pF1KSD VVGSVLNWFSPVQALQKGRTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VVGSVLNWFSPVQALQKGRTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLP 670 680 690 700 710 720 710 720 730 740 750 760 pF1KSD GQKPFKRSLRGSDALSETSSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GQKPFKRSLRGSDALSETSSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTD 730 740 750 760 770 780 770 780 pF1KSD QTEAFQKGVPHPEDDHSQVEGPESLR :::::::::::::::::::::::::: XP_005 QTEAFQKGVPHPEDDHSQVEGPESLR 790 800 >>XP_016878548 (OMIM: 614244) PREDICTED: pyridoxal-depen (773 aa) initn: 5112 init1: 5112 opt: 5112 Z-score: 5109.1 bits: 956.1 E(85289): 0 Smith-Waterman score: 5112; 100.0% identity (100.0% similar) in 773 aa overlap (16-788:1-773) 10 20 30 40 50 60 pF1KSD MDASLEKIADPTLAEMGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPLQGSGQDMVS ::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPLQGSGQDMVS 10 20 30 40 70 80 90 100 110 120 pF1KSD ILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSD 50 60 70 80 90 100 130 140 150 160 170 180 pF1KSD TTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPVIYLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPVIYLSA 110 120 130 140 150 160 190 200 210 220 230 240 pF1KSD AARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIERGRLPLLLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIERGRLPLLLVA 170 180 190 200 210 220 250 260 270 280 290 300 pF1KSD NAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAAAKCDSMTMTPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAAAKCDSMTMTPG 230 240 250 260 270 280 310 320 330 340 350 360 pF1KSD PWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLWLSLQYLGLDGFVERIKHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLWLSLQYLGLDGFVERIKHA 290 300 310 320 330 340 370 380 390 400 410 420 pF1KSD CQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSDPVFKAVPVPNMTPSGVGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSDPVFKAVPVPNMTPSGVGR 350 360 370 380 390 400 430 440 450 460 470 480 pF1KSD ERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPLMTAAVLGTRGEDVDQLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPLMTAAVLGTRGEDVDQLVA 410 420 430 440 450 460 490 500 510 520 530 540 pF1KSD CIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGVVRYEHANDDKSSLKSDPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGVVRYEHANDDKSSLKSDPE 470 480 490 500 510 520 550 560 570 580 590 600 pF1KSD GENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDNVDAAELVETIAATAREIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDNVDAAELVETIAATAREIE 530 540 550 560 570 580 610 620 630 640 650 660 pF1KSD ENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIPVVGSVLNWFSPVQALQKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIPVVGSVLNWFSPVQALQKG 590 600 610 620 630 640 670 680 690 700 710 720 pF1KSD RTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLPGQKPFKRSLRGSDALSET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLPGQKPFKRSLRGSDALSET 650 660 670 680 690 700 730 740 750 760 770 780 pF1KSD SSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQKGVPHPEDDHSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQKGVPHPEDDHSQ 710 720 730 740 750 760 pF1KSD VEGPESLR :::::::: XP_016 VEGPESLR 770 >>XP_005255233 (OMIM: 614244) PREDICTED: pyridoxal-depen (773 aa) initn: 5112 init1: 5112 opt: 5112 Z-score: 5109.1 bits: 956.1 E(85289): 0 Smith-Waterman score: 5112; 100.0% identity (100.0% similar) in 773 aa overlap (16-788:1-773) 10 20 30 40 50 60 pF1KSD MDASLEKIADPTLAEMGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPLQGSGQDMVS ::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPLQGSGQDMVS 10 20 30 40 70 80 90 100 110 120 pF1KSD ILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSD 50 60 70 80 90 100 130 140 150 160 170 180 pF1KSD TTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPVIYLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPVIYLSA 110 120 130 140 150 160 190 200 210 220 230 240 pF1KSD AARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIERGRLPLLLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIERGRLPLLLVA 170 180 190 200 210 220 250 260 270 280 290 300 pF1KSD NAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAAAKCDSMTMTPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAAAKCDSMTMTPG 230 240 250 260 270 280 310 320 330 340 350 360 pF1KSD PWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLWLSLQYLGLDGFVERIKHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLWLSLQYLGLDGFVERIKHA 290 300 310 320 330 340 370 380 390 400 410 420 pF1KSD CQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSDPVFKAVPVPNMTPSGVGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSDPVFKAVPVPNMTPSGVGR 350 360 370 380 390 400 430 440 450 460 470 480 pF1KSD ERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPLMTAAVLGTRGEDVDQLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPLMTAAVLGTRGEDVDQLVA 410 420 430 440 450 460 490 500 510 520 530 540 pF1KSD CIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGVVRYEHANDDKSSLKSDPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGVVRYEHANDDKSSLKSDPE 470 480 490 500 510 520 550 560 570 580 590 600 pF1KSD GENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDNVDAAELVETIAATAREIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDNVDAAELVETIAATAREIE 530 540 550 560 570 580 610 620 630 640 650 660 pF1KSD ENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIPVVGSVLNWFSPVQALQKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIPVVGSVLNWFSPVQALQKG 590 600 610 620 630 640 670 680 690 700 710 720 pF1KSD RTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLPGQKPFKRSLRGSDALSET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLPGQKPFKRSLRGSDALSET 650 660 670 680 690 700 730 740 750 760 770 780 pF1KSD SSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQKGVPHPEDDHSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQKGVPHPEDDHSQ 710 720 730 740 750 760 pF1KSD VEGPESLR :::::::: XP_005 VEGPESLR 770 >>XP_016878550 (OMIM: 614244) PREDICTED: pyridoxal-depen (773 aa) initn: 5112 init1: 5112 opt: 5112 Z-score: 5109.1 bits: 956.1 E(85289): 0 Smith-Waterman score: 5112; 100.0% identity (100.0% similar) in 773 aa overlap (16-788:1-773) 10 20 30 40 50 60 pF1KSD MDASLEKIADPTLAEMGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPLQGSGQDMVS ::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPLQGSGQDMVS 10 20 30 40 70 80 90 100 110 120 pF1KSD ILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSD 50 60 70 80 90 100 130 140 150 160 170 180 pF1KSD TTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPVIYLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPVIYLSA 110 120 130 140 150 160 190 200 210 220 230 240 pF1KSD AARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIERGRLPLLLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIERGRLPLLLVA 170 180 190 200 210 220 250 260 270 280 290 300 pF1KSD NAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAAAKCDSMTMTPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAAAKCDSMTMTPG 230 240 250 260 270 280 310 320 330 340 350 360 pF1KSD PWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLWLSLQYLGLDGFVERIKHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLWLSLQYLGLDGFVERIKHA 290 300 310 320 330 340 370 380 390 400 410 420 pF1KSD CQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSDPVFKAVPVPNMTPSGVGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSDPVFKAVPVPNMTPSGVGR 350 360 370 380 390 400 430 440 450 460 470 480 pF1KSD ERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPLMTAAVLGTRGEDVDQLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPLMTAAVLGTRGEDVDQLVA 410 420 430 440 450 460 490 500 510 520 530 540 pF1KSD CIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGVVRYEHANDDKSSLKSDPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGVVRYEHANDDKSSLKSDPE 470 480 490 500 510 520 550 560 570 580 590 600 pF1KSD GENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDNVDAAELVETIAATAREIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDNVDAAELVETIAATAREIE 530 540 550 560 570 580 610 620 630 640 650 660 pF1KSD ENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIPVVGSVLNWFSPVQALQKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIPVVGSVLNWFSPVQALQKG 590 600 610 620 630 640 670 680 690 700 710 720 pF1KSD RTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLPGQKPFKRSLRGSDALSET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLPGQKPFKRSLRGSDALSET 650 660 670 680 690 700 730 740 750 760 770 780 pF1KSD SSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQKGVPHPEDDHSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQKGVPHPEDDHSQ 710 720 730 740 750 760 pF1KSD VEGPESLR :::::::: XP_016 VEGPESLR 770 >>NP_001272376 (OMIM: 614244) pyridoxal-dependent decarb (773 aa) initn: 5112 init1: 5112 opt: 5112 Z-score: 5109.1 bits: 956.1 E(85289): 0 Smith-Waterman score: 5112; 100.0% identity (100.0% similar) in 773 aa overlap (16-788:1-773) 10 20 30 40 50 60 pF1KSD MDASLEKIADPTLAEMGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPLQGSGQDMVS ::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPLQGSGQDMVS 10 20 30 40 70 80 90 100 110 120 pF1KSD ILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSD 50 60 70 80 90 100 130 140 150 160 170 180 pF1KSD TTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPVIYLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPVIYLSA 110 120 130 140 150 160 190 200 210 220 230 240 pF1KSD AARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIERGRLPLLLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIERGRLPLLLVA 170 180 190 200 210 220 250 260 270 280 290 300 pF1KSD NAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAAAKCDSMTMTPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAAAKCDSMTMTPG 230 240 250 260 270 280 310 320 330 340 350 360 pF1KSD PWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLWLSLQYLGLDGFVERIKHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLWLSLQYLGLDGFVERIKHA 290 300 310 320 330 340 370 380 390 400 410 420 pF1KSD CQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSDPVFKAVPVPNMTPSGVGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSDPVFKAVPVPNMTPSGVGR 350 360 370 380 390 400 430 440 450 460 470 480 pF1KSD ERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPLMTAAVLGTRGEDVDQLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPLMTAAVLGTRGEDVDQLVA 410 420 430 440 450 460 490 500 510 520 530 540 pF1KSD CIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGVVRYEHANDDKSSLKSDPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGVVRYEHANDDKSSLKSDPE 470 480 490 500 510 520 550 560 570 580 590 600 pF1KSD GENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDNVDAAELVETIAATAREIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDNVDAAELVETIAATAREIE 530 540 550 560 570 580 610 620 630 640 650 660 pF1KSD ENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIPVVGSVLNWFSPVQALQKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIPVVGSVLNWFSPVQALQKG 590 600 610 620 630 640 670 680 690 700 710 720 pF1KSD RTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLPGQKPFKRSLRGSDALSET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLPGQKPFKRSLRGSDALSET 650 660 670 680 690 700 730 740 750 760 770 780 pF1KSD SSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQKGVPHPEDDHSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQKGVPHPEDDHSQ 710 720 730 740 750 760 pF1KSD VEGPESLR :::::::: NP_001 VEGPESLR 770 >>XP_016878551 (OMIM: 614244) PREDICTED: pyridoxal-depen (773 aa) initn: 5112 init1: 5112 opt: 5112 Z-score: 5109.1 bits: 956.1 E(85289): 0 Smith-Waterman score: 5112; 100.0% identity (100.0% similar) in 773 aa overlap (16-788:1-773) 10 20 30 40 50 60 pF1KSD MDASLEKIADPTLAEMGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPLQGSGQDMVS ::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPLQGSGQDMVS 10 20 30 40 70 80 90 100 110 120 pF1KSD ILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSD 50 60 70 80 90 100 130 140 150 160 170 180 pF1KSD TTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPVIYLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPVIYLSA 110 120 130 140 150 160 190 200 210 220 230 240 pF1KSD AARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIERGRLPLLLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIERGRLPLLLVA 170 180 190 200 210 220 250 260 270 280 290 300 pF1KSD NAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAAAKCDSMTMTPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAAAKCDSMTMTPG 230 240 250 260 270 280 310 320 330 340 350 360 pF1KSD PWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLWLSLQYLGLDGFVERIKHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLWLSLQYLGLDGFVERIKHA 290 300 310 320 330 340 370 380 390 400 410 420 pF1KSD CQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSDPVFKAVPVPNMTPSGVGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSDPVFKAVPVPNMTPSGVGR 350 360 370 380 390 400 430 440 450 460 470 480 pF1KSD ERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPLMTAAVLGTRGEDVDQLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPLMTAAVLGTRGEDVDQLVA 410 420 430 440 450 460 490 500 510 520 530 540 pF1KSD CIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGVVRYEHANDDKSSLKSDPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGVVRYEHANDDKSSLKSDPE 470 480 490 500 510 520 550 560 570 580 590 600 pF1KSD GENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDNVDAAELVETIAATAREIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDNVDAAELVETIAATAREIE 530 540 550 560 570 580 610 620 630 640 650 660 pF1KSD ENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIPVVGSVLNWFSPVQALQKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIPVVGSVLNWFSPVQALQKG 590 600 610 620 630 640 670 680 690 700 710 720 pF1KSD RTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLPGQKPFKRSLRGSDALSET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLPGQKPFKRSLRGSDALSET 650 660 670 680 690 700 730 740 750 760 770 780 pF1KSD SSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQKGVPHPEDDHSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQKGVPHPEDDHSQ 710 720 730 740 750 760 pF1KSD VEGPESLR :::::::: XP_016 VEGPESLR 770 >>XP_016878553 (OMIM: 614244) PREDICTED: pyridoxal-depen (746 aa) initn: 4689 init1: 4689 opt: 4693 Z-score: 4690.6 bits: 878.7 E(85289): 0 Smith-Waterman score: 4866; 96.5% identity (96.5% similar) in 773 aa overlap (16-788:1-746) 10 20 30 40 50 60 pF1KSD MDASLEKIADPTLAEMGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPLQGSGQDMVS :::::::::::::::::::::::::::::::::::::: XP_016 MGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPLQG------- 10 20 30 70 80 90 100 110 120 pF1KSD ILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSD :::::::::::::::::::::::::::::::::::::::: XP_016 --------------------RIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSD 40 50 60 70 130 140 150 160 170 180 pF1KSD TTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPVIYLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPVIYLSA 80 90 100 110 120 130 190 200 210 220 230 240 pF1KSD AARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIERGRLPLLLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIERGRLPLLLVA 140 150 160 170 180 190 250 260 270 280 290 300 pF1KSD NAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAAAKCDSMTMTPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAAAKCDSMTMTPG 200 210 220 230 240 250 310 320 330 340 350 360 pF1KSD PWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLWLSLQYLGLDGFVERIKHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLWLSLQYLGLDGFVERIKHA 260 270 280 290 300 310 370 380 390 400 410 420 pF1KSD CQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSDPVFKAVPVPNMTPSGVGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSDPVFKAVPVPNMTPSGVGR 320 330 340 350 360 370 430 440 450 460 470 480 pF1KSD ERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPLMTAAVLGTRGEDVDQLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPLMTAAVLGTRGEDVDQLVA 380 390 400 410 420 430 490 500 510 520 530 540 pF1KSD CIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGVVRYEHANDDKSSLKSDPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGVVRYEHANDDKSSLKSDPE 440 450 460 470 480 490 550 560 570 580 590 600 pF1KSD GENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDNVDAAELVETIAATAREIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDNVDAAELVETIAATAREIE 500 510 520 530 540 550 610 620 630 640 650 660 pF1KSD ENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIPVVGSVLNWFSPVQALQKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIPVVGSVLNWFSPVQALQKG 560 570 580 590 600 610 670 680 690 700 710 720 pF1KSD RTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLPGQKPFKRSLRGSDALSET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLPGQKPFKRSLRGSDALSET 620 630 640 650 660 670 730 740 750 760 770 780 pF1KSD SSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQKGVPHPEDDHSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQKGVPHPEDDHSQ 680 690 700 710 720 730 pF1KSD VEGPESLR :::::::: XP_016 VEGPESLR 740 788 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 00:55:57 2016 done: Thu Nov 3 00:55:59 2016 Total Scan time: 12.950 Total Display time: 0.260 Function used was FASTA [36.3.4 Apr, 2011]