FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0263, 441 aa 1>>>pF1KSDA0263 441 - 441 aa - 441 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5119+/-0.000786; mu= 12.0676+/- 0.048 mean_var=88.8354+/-17.420, 0's: 0 Z-trim(109.6): 12 B-trim: 0 in 0/51 Lambda= 0.136076 statistics sampled from 11015 (11024) to 11015 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.715), E-opt: 0.2 (0.339), width: 16 Scan time: 3.190 The best scores are: opt bits E(32554) CCDS33760.1 IP6K1 gene_id:9807|Hs108|chr3 ( 441) 2991 597.0 1.2e-170 CCDS43092.1 IP6K1 gene_id:9807|Hs108|chr3 ( 276) 1875 377.8 7.3e-105 CCDS34435.1 IP6K3 gene_id:117283|Hs108|chr6 ( 410) 1179 241.3 1.4e-63 CCDS2777.1 IP6K2 gene_id:51447|Hs108|chr3 ( 426) 1156 236.7 3.3e-62 CCDS7250.1 IPMK gene_id:253430|Hs108|chr10 ( 416) 312 71.1 2.4e-12 CCDS54579.1 IP6K2 gene_id:51447|Hs108|chr3 ( 87) 288 66.1 1.6e-11 CCDS33752.1 IP6K2 gene_id:51447|Hs108|chr3 ( 97) 283 65.1 3.5e-11 CCDS54580.1 IP6K2 gene_id:51447|Hs108|chr3 ( 185) 283 65.2 6.2e-11 CCDS54581.1 IP6K2 gene_id:51447|Hs108|chr3 ( 188) 283 65.2 6.2e-11 >>CCDS33760.1 IP6K1 gene_id:9807|Hs108|chr3 (441 aa) initn: 2991 init1: 2991 opt: 2991 Z-score: 3177.0 bits: 597.0 E(32554): 1.2e-170 Smith-Waterman score: 2991; 100.0% identity (100.0% similar) in 441 aa overlap (1-441:1-441) 10 20 30 40 50 60 pF1KSD MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDDHTVCKPLISREQRFYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDDHTVCKPLISREQRFYE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD SLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETVEQDDTTEREQPRRKHSRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 SLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETVEQDDTTEREQPRRKHSRR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD SLHRSGSGSDHKEEKASLSLETSESSQEAKSPKVELHSHSEVPFQMLDGNSGLSSEKISH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 SLHRSGSGSDHKEEKASLSLETSESSQEAKSPKVELHSHSEVPFQMLDGNSGLSSEKISH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD NPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFKYPCVLDLKMGTRQHGDDASAEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 NPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFKYPCVLDLKMGTRQHGDDASAEK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD AARQMRKCEQSTSATLGVRVCGMQVYQLDTGHYLCRNKYYGRGLSIEGFRNALYQYLHNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 AARQMRKCEQSTSATLGVRVCGMQVYQLDTGHYLCRNKYYGRGLSIEGFRNALYQYLHNG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD LDLRRDLFEPILSKLRGLKAVLERQASYRFYSSSLLVIYDGKECRAESCLDRRSEMRLKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 LDLRRDLFEPILSKLRGLKAVLERQASYRFYSSSLLVIYDGKECRAESCLDRRSEMRLKH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD LDMVLPEVASSCGPSTSPSNTSPEAGPSSQPKVDVRMIDFAHSTFKGFRDDPTVHDGPDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 LDMVLPEVASSCGPSTSPSNTSPEAGPSSQPKVDVRMIDFAHSTFKGFRDDPTVHDGPDR 370 380 390 400 410 420 430 440 pF1KSD GYVFGLENLISIMEQMRDENQ ::::::::::::::::::::: CCDS33 GYVFGLENLISIMEQMRDENQ 430 440 >>CCDS43092.1 IP6K1 gene_id:9807|Hs108|chr3 (276 aa) initn: 1875 init1: 1875 opt: 1875 Z-score: 1996.1 bits: 377.8 E(32554): 7.3e-105 Smith-Waterman score: 1875; 100.0% identity (100.0% similar) in 276 aa overlap (166-441:1-276) 140 150 160 170 180 190 pF1KSD ASLSLETSESSQEAKSPKVELHSHSEVPFQMLDGNSGLSSEKISHNPWSLRCHKQQLSRM :::::::::::::::::::::::::::::: CCDS43 MLDGNSGLSSEKISHNPWSLRCHKQQLSRM 10 20 30 200 210 220 230 240 250 pF1KSD RSESKDRKLYKFLLLENVVHHFKYPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 RSESKDRKLYKFLLLENVVHHFKYPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSAT 40 50 60 70 80 90 260 270 280 290 300 310 pF1KSD LGVRVCGMQVYQLDTGHYLCRNKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 LGVRVCGMQVYQLDTGHYLCRNKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKL 100 110 120 130 140 150 320 330 340 350 360 370 pF1KSD RGLKAVLERQASYRFYSSSLLVIYDGKECRAESCLDRRSEMRLKHLDMVLPEVASSCGPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 RGLKAVLERQASYRFYSSSLLVIYDGKECRAESCLDRRSEMRLKHLDMVLPEVASSCGPS 160 170 180 190 200 210 380 390 400 410 420 430 pF1KSD TSPSNTSPEAGPSSQPKVDVRMIDFAHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 TSPSNTSPEAGPSSQPKVDVRMIDFAHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQ 220 230 240 250 260 270 440 pF1KSD MRDENQ :::::: CCDS43 MRDENQ >>CCDS34435.1 IP6K3 gene_id:117283|Hs108|chr6 (410 aa) initn: 1361 init1: 791 opt: 1179 Z-score: 1255.0 bits: 241.3 E(32554): 1.4e-63 Smith-Waterman score: 1361; 50.6% identity (72.7% similar) in 433 aa overlap (14-438:4-408) 10 20 30 40 50 pF1KSD MCVCQTMEVGQYGKNASRAGDR--GVLLEPFIHQVGGHSSMMRYDDHTVCKPLISREQRF .:.. ::: :: ::::.:::::: :.:.::.:::::::.:::::: CCDS34 MVVQNSADAGDMRAGVQLEPFLHQVGGHMSVMKYDEHTVCKPLVSREQRF 10 20 30 40 50 60 70 80 90 100 110 pF1KSD YESLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETVEQDDTTEREQPRRKHS ::::: ::.:::.:::.:.: . :: :...::: : ::. . .: . CCDS34 YESLPLAMKRFTPQYKGTVTVHLWKDSTGHLSLVANPVKESQEPFKVSTESAAVAIWQTL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KSD RRSLHRSGSGSDHKE-EKASLSLETSESSQEAKSPKVELHSHSEVP-FQMLDGNSGLSSE ... .:: . .:.:. .:: .: .. . : ..: :.... ..: . : CCDS34 QQTTGSNGSDCTLAQWPHAQLARSPKESPAKAL---LRSEPHLNTPAFSLVEDTNGNQVE 120 130 140 150 160 180 190 200 210 220 230 pF1KSD KISHNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFKYPCVLDLKMGTRQHGDDA . : :::.:.::. .:.:. :: . : ..:::::::: .. .::::::::::::::::: CCDS34 RKSFNPWGLQCHQAHLTRLCSEYPENKRHRFLLLENVVSQYTHPCVLDLKMGTRQHGDDA 170 180 190 200 210 220 240 250 260 270 280 290 pF1KSD SAEKAARQMRKCEQSTSATLGVRVCGMQVYQLDTGHYLCRNKYYGRGLSIEGFRNALYQY : :: ::.:::: ::::: ::::.::::::: : ..::..::::: ::.::::.::::. CCDS34 SEEKKARHMRKCAQSTSACLGVRICGMQVYQTDKKYFLCKDKYYGRKLSVEGFRQALYQF 230 240 250 260 270 280 300 310 320 330 340 350 pF1KSD LHNGLDLRRDLFEPILSKLRGLKAVLERQASYRFYSSSLLVIYDGKECRAESCLDRRSEM :::: :::.:.:::: .::.: .:.. :.:::::::::::::::.: CCDS34 LHNGSHLRRELLEPILHQLRALLSVIRSQSSYRFYSSSLLVIYDGQEP------------ 290 300 310 320 330 360 370 380 390 400 410 pF1KSD RLKHLDMVLPEVASSCGPSTSPSNTSPEAGPSSQP----KVDVRMIDFAHSTFKGFRDDP :: : :.. . .:.:. .:.: :::.:::::::.:.::. .. CCDS34 ---------PERA----PGSPHPHEAPQAAHGSSPGGLTKVDIRMIDFAHTTYKGYWNEH 340 350 360 370 380 420 430 440 pF1KSD TVHDGPDRGYVFGLENLISIMEQMRDENQ :..:::: ::.::::::: :...... CCDS34 TTYDGPDPGYIFGLENLIRILQDIQEGE 390 400 410 >>CCDS2777.1 IP6K2 gene_id:51447|Hs108|chr3 (426 aa) initn: 1316 init1: 809 opt: 1156 Z-score: 1230.3 bits: 236.7 E(32554): 3.3e-62 Smith-Waterman score: 1310; 49.3% identity (74.3% similar) in 424 aa overlap (22-440:15-424) 10 20 30 40 50 60 pF1KSD MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDDHTVCKPLISREQRFYE .:::::::.::::::: ..:... :.::::. ::..::: CCDS27 MSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQFYE 10 20 30 40 50 70 80 90 100 110 pF1KSD SLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYV-ESETVEQDDTTEREQPRRKHSR .:: ::..:::.::::::: :: : : . :.::: . :. :... : :. : : CCDS27 TLPAEMRKFTPQYKGVVSVRFEEDEDRNLCLIAYPLKGDHGIVDIVDNSDCE-PKSKLLR 60 70 80 90 100 110 120 130 140 150 160 170 pF1KSD RSLHRSGSGSDHKEEKASLSLETSESSQEAKSPKVELH----SHSEVPFQMLDGNSGLSS . ... . :. . .. .. .. :: :.: . ..::: . .. ....:: CCDS27 WTTNKKHHVLE-TEKTPKDWVRQHRKEEKMKSHKLEEEFEWLKKSEVLYYTVEKKGNISS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KSD EKISHNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFKYPCVLDLKMGTRQHGDD . .::::..::.:::.::. ..: :. :::.::::.. ... :::::::::::::::: CCDS27 QLKHYNPWSMKCHQQQLQRMKENAKHRNQYKFILLENLTSRYEVPCVLDLKMGTRQHGDD 180 190 200 210 220 230 240 250 260 270 280 290 pF1KSD ASAEKAARQMRKCEQSTSATLGVRVCGMQVYQLDTGHYLCRNKYYGRGLSIEGFRNALYQ :: :::: :.:::.:::::..::::::::::: .:. . :::.:: ::..::..::.: CCDS27 ASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGSGQLMFMNKYHGRKLSVQGFKEALFQ 240 250 260 270 280 290 300 310 320 330 340 350 pF1KSD YLHNGLDLRRDLFEPILSKLRGLKAVLERQASYRFYSSSLLVIYDGKECRAESCLDRRSE ..::: :::.:. :.:.:: :::::::: ::::::::::::::::: : : :: .: CCDS27 FFHNGRYLRRELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGKE-RPEVVLDSDAE 300 310 320 330 340 350 360 370 380 390 400 410 pF1KSD MRLKHLDMVLPEVASSCGPSTSPSNTSPEAGPSSQPKVDVRMIDFAHSTFKGFRDDPTVH : : ... . .. . . : :: ::::::::::.: . . .: .:: CCDS27 ------D--LEDLSEESADESAGAYAYKPIGASS---VDVRMIDFAHTTCRLYGEDTVVH 360 370 380 390 420 430 440 pF1KSD DGPDRGYVFGLENLISIMEQMRDENQ .: : ::.:::..::.:. .. .:. CCDS27 EGQDAGYIFGLQSLIDIVTEISEESGE 400 410 420 >>CCDS7250.1 IPMK gene_id:253430|Hs108|chr10 (416 aa) initn: 437 init1: 192 opt: 312 Z-score: 335.0 bits: 71.1 E(32554): 2.4e-12 Smith-Waterman score: 312; 33.1% identity (66.2% similar) in 148 aa overlap (207-354:127-272) 180 190 200 210 220 230 pF1KSD KISHNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFKYPCVLDLKMGTRQHGDDA .: ::.:.:.:. ::..:.:.: ... : CCDS72 DCFDGVLLELRKYLPKYYGIWSPPTAPNDLYLKLEDVTHKFNKPCIMDVKIGQKSYDPFA 100 110 120 130 140 150 240 250 260 270 280 290 pF1KSD SAEKAARQMRKCEQSTSATLGVRVCGMQVYQLDTGHYLCRNKYYGRGLSIEGFRNALYQY :.:: .:. : .: : ::.::.. . : .:..:::.:. : ..... .. CCDS72 SSEKIQQQVSK--YPLMEEIGFLVLGMRVYHVHSDSYETENQHYGRSLTKETIKDGVSRF 160 170 180 190 200 210 300 310 320 330 340 350 pF1KSD LHNGLDLRRDLFEPILSKLRGLKAVLERQASYRFYSSSLLVIYDGKECRAESCLDRRSEM .::: ::.: ..:.. . .: : . ::.:::: .:.:. . . :. :. CCDS72 FHNGYCLRKDAVAASIQKIEKILQWFENQKQLNFYASSLLFVYEGSSQPTTTKLNDRTLA 220 230 240 250 260 270 360 370 380 390 400 410 pF1KSD RLKHLDMVLPEVASSCGPSTSPSNTSPEAGPSSQPKVDVRMIDFAHSTFKGFRDDPTVHD CCDS72 EKFLSKGQLSDTEVLEYNNNFHVLSSTANGKIESSVGKSLSKMYARHRKIYTKKHHSQTS 280 290 300 310 320 330 >>CCDS54579.1 IP6K2 gene_id:51447|Hs108|chr3 (87 aa) initn: 285 init1: 285 opt: 288 Z-score: 320.3 bits: 66.1 E(32554): 1.6e-11 Smith-Waterman score: 288; 63.2% identity (91.2% similar) in 57 aa overlap (22-78:15-71) 10 20 30 40 50 60 pF1KSD MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDDHTVCKPLISREQRFYE .:::::::.::::::: ..:... :.::::. ::..::: CCDS54 MSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQFYE 10 20 30 40 50 70 80 90 100 110 120 pF1KSD SLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETVEQDDTTEREQPRRKHSRR .:: ::..:::.::: .: CCDS54 TLPAEMRKFTPQYKGDISSHQHGGVFVGEWGSLL 60 70 80 >>CCDS33752.1 IP6K2 gene_id:51447|Hs108|chr3 (97 aa) initn: 300 init1: 283 opt: 283 Z-score: 314.3 bits: 65.1 E(32554): 3.5e-11 Smith-Waterman score: 283; 64.8% identity (92.6% similar) in 54 aa overlap (22-75:15-68) 10 20 30 40 50 60 pF1KSD MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDDHTVCKPLISREQRFYE .:::::::.::::::: ..:... :.::::. ::..::: CCDS33 MSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQFYE 10 20 30 40 50 70 80 90 100 110 120 pF1KSD SLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETVEQDDTTEREQPRRKHSRR .:: ::..:::.::: CCDS33 TLPAEMRKFTPQYKGQSQRPLVSWPSLPHFFPWSFPLWPQGSVA 60 70 80 90 >>CCDS54580.1 IP6K2 gene_id:51447|Hs108|chr3 (185 aa) initn: 301 init1: 283 opt: 283 Z-score: 309.8 bits: 65.2 E(32554): 6.2e-11 Smith-Waterman score: 283; 64.8% identity (92.6% similar) in 54 aa overlap (22-75:70-123) 10 20 30 40 50 pF1KSD MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDDHTVCKPL .:::::::.::::::: ..:... :.:::: CCDS54 AGLRCLPHLPAICARRMSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPL 40 50 60 70 80 90 60 70 80 90 100 110 pF1KSD ISREQRFYESLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETVEQDDTTERE . ::..:::.:: ::..:::.::: CCDS54 VPREHQFYETLPAEMRKFTPQYKGKSQLLEGLPHWRGDVRDRGHGRPWQPSLEPSLPPTL 100 110 120 130 140 150 >>CCDS54581.1 IP6K2 gene_id:51447|Hs108|chr3 (188 aa) initn: 301 init1: 283 opt: 283 Z-score: 309.7 bits: 65.2 E(32554): 6.2e-11 Smith-Waterman score: 283; 64.8% identity (92.6% similar) in 54 aa overlap (22-75:73-126) 10 20 30 40 50 pF1KSD MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDDHTVCKPL .:::::::.::::::: ..:... :.:::: CCDS54 AGLRCLPHLPAICARRMSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPL 50 60 70 80 90 100 60 70 80 90 100 110 pF1KSD ISREQRFYESLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETVEQDDTTERE . ::..:::.:: ::..:::.::: CCDS54 VPREHQFYETLPAEMRKFTPQYKGKSQLLEGLPHWRGDVRDRGHGRPWQPSLEPSLPPTL 110 120 130 140 150 160 441 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 18:29:31 2016 done: Thu Nov 3 18:29:32 2016 Total Scan time: 3.190 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]