FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0269, 559 aa 1>>>pF1KSDA0269 559 - 559 aa - 559 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 17.5447+/-0.000508; mu= -36.6130+/- 0.032 mean_var=915.1988+/-188.555, 0's: 0 Z-trim(125.6): 120 B-trim: 0 in 0/61 Lambda= 0.042395 statistics sampled from 49427 (49588) to 49427 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.815), E-opt: 0.2 (0.581), width: 16 Scan time: 10.920 The best scores are: opt bits E(85289) XP_005267262 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 3878 252.5 2.6e-66 XP_011534536 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 3878 252.5 2.6e-66 NP_003922 (OMIM: 605035) wiskott-Aldrich syndrome ( 559) 3878 252.5 2.6e-66 NP_001020105 (OMIM: 605035) wiskott-Aldrich syndro ( 559) 3878 252.5 2.6e-66 NP_001020106 (OMIM: 605035) wiskott-Aldrich syndro ( 559) 3878 252.5 2.6e-66 XP_005267260 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 3878 252.5 2.6e-66 XP_016866927 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 3878 252.5 2.6e-66 XP_011534535 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 3878 252.5 2.6e-66 XP_005267263 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 3878 252.5 2.6e-66 NP_001020107 (OMIM: 605035) wiskott-Aldrich syndro ( 559) 3878 252.5 2.6e-66 XP_005267264 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 3878 252.5 2.6e-66 XP_016866926 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 3878 252.5 2.6e-66 XP_016866930 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 3859 251.3 5.8e-66 XP_016866933 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 3859 251.3 5.8e-66 XP_016866932 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 3859 251.3 5.8e-66 XP_016866928 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 3859 251.3 5.8e-66 XP_011534537 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 3859 251.3 5.8e-66 XP_016866929 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 3859 251.3 5.8e-66 XP_016866931 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 3859 251.3 5.8e-66 NP_008921 (OMIM: 605875) wiskott-Aldrich syndrome ( 498) 1240 91.1 8.8e-18 XP_011533191 (OMIM: 605068) PREDICTED: wiskott-Ald ( 502) 1182 87.6 1e-16 NP_006637 (OMIM: 605068) wiskott-Aldrich syndrome ( 502) 1182 87.6 1e-16 XP_011533192 (OMIM: 605068) PREDICTED: wiskott-Ald ( 502) 1182 87.6 1e-16 NP_001278894 (OMIM: 605068) wiskott-Aldrich syndro ( 499) 1151 85.7 3.8e-16 NP_001188333 (OMIM: 605875) wiskott-Aldrich syndro ( 281) 1011 76.9 9.5e-14 XP_016857330 (OMIM: 606373,616193) PREDICTED: form (1102) 462 43.8 0.0034 XP_016857329 (OMIM: 606373,616193) PREDICTED: form (1102) 462 43.8 0.0034 XP_016857328 (OMIM: 606373,616193) PREDICTED: form (1159) 462 43.8 0.0035 XP_011542539 (OMIM: 606373,616193) PREDICTED: form (1360) 462 43.9 0.0039 XP_016857327 (OMIM: 606373,616193) PREDICTED: form (1384) 462 43.9 0.004 XP_016857326 (OMIM: 606373,616193) PREDICTED: form (1417) 462 43.9 0.0041 NP_064450 (OMIM: 606373,616193) formin-2 isoform 2 (1722) 462 44.0 0.0047 NP_001292353 (OMIM: 606373,616193) formin-2 isofor (1726) 462 44.0 0.0047 >>XP_005267262 (OMIM: 605035) PREDICTED: wiskott-Aldrich (559 aa) initn: 3878 init1: 3878 opt: 3878 Z-score: 1311.5 bits: 252.5 E(85289): 2.6e-66 Smith-Waterman score: 3878; 100.0% identity (100.0% similar) in 559 aa overlap (1-559:1-559) 10 20 30 40 50 60 pF1KSD MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD QGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD ASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIA 490 500 510 520 530 540 550 pF1KSD VEYSDSEDDSEFDEVDWLE ::::::::::::::::::: XP_005 VEYSDSEDDSEFDEVDWLE 550 >>XP_011534536 (OMIM: 605035) PREDICTED: wiskott-Aldrich (559 aa) initn: 3878 init1: 3878 opt: 3878 Z-score: 1311.5 bits: 252.5 E(85289): 2.6e-66 Smith-Waterman score: 3878; 100.0% identity (100.0% similar) in 559 aa overlap (1-559:1-559) 10 20 30 40 50 60 pF1KSD MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD QGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD ASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIA 490 500 510 520 530 540 550 pF1KSD VEYSDSEDDSEFDEVDWLE ::::::::::::::::::: XP_011 VEYSDSEDDSEFDEVDWLE 550 >>NP_003922 (OMIM: 605035) wiskott-Aldrich syndrome prot (559 aa) initn: 3878 init1: 3878 opt: 3878 Z-score: 1311.5 bits: 252.5 E(85289): 2.6e-66 Smith-Waterman score: 3878; 100.0% identity (100.0% similar) in 559 aa overlap (1-559:1-559) 10 20 30 40 50 60 pF1KSD MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD QGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD ASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIA 490 500 510 520 530 540 550 pF1KSD VEYSDSEDDSEFDEVDWLE ::::::::::::::::::: NP_003 VEYSDSEDDSEFDEVDWLE 550 >>NP_001020105 (OMIM: 605035) wiskott-Aldrich syndrome p (559 aa) initn: 3878 init1: 3878 opt: 3878 Z-score: 1311.5 bits: 252.5 E(85289): 2.6e-66 Smith-Waterman score: 3878; 100.0% identity (100.0% similar) in 559 aa overlap (1-559:1-559) 10 20 30 40 50 60 pF1KSD MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD QGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD ASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIA 490 500 510 520 530 540 550 pF1KSD VEYSDSEDDSEFDEVDWLE ::::::::::::::::::: NP_001 VEYSDSEDDSEFDEVDWLE 550 >>NP_001020106 (OMIM: 605035) wiskott-Aldrich syndrome p (559 aa) initn: 3878 init1: 3878 opt: 3878 Z-score: 1311.5 bits: 252.5 E(85289): 2.6e-66 Smith-Waterman score: 3878; 100.0% identity (100.0% similar) in 559 aa overlap (1-559:1-559) 10 20 30 40 50 60 pF1KSD MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD QGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD ASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIA 490 500 510 520 530 540 550 pF1KSD VEYSDSEDDSEFDEVDWLE ::::::::::::::::::: NP_001 VEYSDSEDDSEFDEVDWLE 550 >>XP_005267260 (OMIM: 605035) PREDICTED: wiskott-Aldrich (559 aa) initn: 3878 init1: 3878 opt: 3878 Z-score: 1311.5 bits: 252.5 E(85289): 2.6e-66 Smith-Waterman score: 3878; 100.0% identity (100.0% similar) in 559 aa overlap (1-559:1-559) 10 20 30 40 50 60 pF1KSD MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD QGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD ASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIA 490 500 510 520 530 540 550 pF1KSD VEYSDSEDDSEFDEVDWLE ::::::::::::::::::: XP_005 VEYSDSEDDSEFDEVDWLE 550 >>XP_016866927 (OMIM: 605035) PREDICTED: wiskott-Aldrich (559 aa) initn: 3878 init1: 3878 opt: 3878 Z-score: 1311.5 bits: 252.5 E(85289): 2.6e-66 Smith-Waterman score: 3878; 100.0% identity (100.0% similar) in 559 aa overlap (1-559:1-559) 10 20 30 40 50 60 pF1KSD MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD QGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD ASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIA 490 500 510 520 530 540 550 pF1KSD VEYSDSEDDSEFDEVDWLE ::::::::::::::::::: XP_016 VEYSDSEDDSEFDEVDWLE 550 >>XP_011534535 (OMIM: 605035) PREDICTED: wiskott-Aldrich (559 aa) initn: 3878 init1: 3878 opt: 3878 Z-score: 1311.5 bits: 252.5 E(85289): 2.6e-66 Smith-Waterman score: 3878; 100.0% identity (100.0% similar) in 559 aa overlap (1-559:1-559) 10 20 30 40 50 60 pF1KSD MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD QGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD ASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIA 490 500 510 520 530 540 550 pF1KSD VEYSDSEDDSEFDEVDWLE ::::::::::::::::::: XP_011 VEYSDSEDDSEFDEVDWLE 550 >>XP_005267263 (OMIM: 605035) PREDICTED: wiskott-Aldrich (559 aa) initn: 3878 init1: 3878 opt: 3878 Z-score: 1311.5 bits: 252.5 E(85289): 2.6e-66 Smith-Waterman score: 3878; 100.0% identity (100.0% similar) in 559 aa overlap (1-559:1-559) 10 20 30 40 50 60 pF1KSD MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD QGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD ASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIA 490 500 510 520 530 540 550 pF1KSD VEYSDSEDDSEFDEVDWLE ::::::::::::::::::: XP_005 VEYSDSEDDSEFDEVDWLE 550 >>NP_001020107 (OMIM: 605035) wiskott-Aldrich syndrome p (559 aa) initn: 3878 init1: 3878 opt: 3878 Z-score: 1311.5 bits: 252.5 E(85289): 2.6e-66 Smith-Waterman score: 3878; 100.0% identity (100.0% similar) in 559 aa overlap (1-559:1-559) 10 20 30 40 50 60 pF1KSD MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD QGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD ASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIA 490 500 510 520 530 540 550 pF1KSD VEYSDSEDDSEFDEVDWLE ::::::::::::::::::: NP_001 VEYSDSEDDSEFDEVDWLE 550 559 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 01:00:02 2016 done: Thu Nov 3 01:00:04 2016 Total Scan time: 10.920 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]