FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0271, 193 aa 1>>>pF1KSDA0271 193 - 193 aa - 193 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9639+/-0.000314; mu= 15.2929+/- 0.020 mean_var=62.3319+/-12.363, 0's: 0 Z-trim(116.3): 44 B-trim: 0 in 0/53 Lambda= 0.162450 statistics sampled from 27283 (27333) to 27283 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.703), E-opt: 0.2 (0.32), width: 16 Scan time: 4.090 The best scores are: opt bits E(85289) NP_004041 (OMIM: 601931) bcl-2-like protein 2 [Hom ( 193) 1296 311.7 4.7e-85 NP_001186768 (OMIM: 601931) bcl-2-like protein 2 [ ( 193) 1296 311.7 4.7e-85 XP_016883482 (OMIM: 600039) PREDICTED: bcl-2-like ( 233) 530 132.2 6.1e-31 NP_001309169 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 530 132.2 6.1e-31 NP_001304848 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 530 132.2 6.1e-31 NP_001309168 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 530 132.2 6.1e-31 NP_001304849 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 530 132.2 6.1e-31 NP_001304850 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 530 132.2 6.1e-31 XP_011527266 (OMIM: 600039) PREDICTED: bcl-2-like ( 233) 530 132.2 6.1e-31 NP_612815 (OMIM: 600039) bcl-2-like protein 1 isof ( 233) 530 132.2 6.1e-31 NP_001309171 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 530 132.2 6.1e-31 NP_000624 (OMIM: 151430) apoptosis regulator Bcl-2 ( 239) 514 128.5 8.3e-30 XP_011524437 (OMIM: 151430) PREDICTED: apoptosis r ( 224) 437 110.4 2.1e-24 XP_016881406 (OMIM: 151430) PREDICTED: apoptosis r ( 198) 434 109.7 3.1e-24 NP_000648 (OMIM: 151430) apoptosis regulator Bcl-2 ( 205) 434 109.7 3.2e-24 XP_011513082 (OMIM: 600516) PREDICTED: bcl-2 homol ( 152) 210 57.1 1.6e-08 NP_001179 (OMIM: 600516) bcl-2 homologous antagoni ( 211) 210 57.2 2.1e-08 XP_011513081 (OMIM: 600516) PREDICTED: bcl-2 homol ( 211) 210 57.2 2.1e-08 XP_016882566 (OMIM: 600040) PREDICTED: apoptosis r ( 173) 199 54.6 1.1e-07 NP_620116 (OMIM: 600040) apoptosis regulator BAX i ( 192) 199 54.6 1.2e-07 NP_004315 (OMIM: 600040) apoptosis regulator BAX i ( 218) 193 53.2 3.4e-07 NP_620119 (OMIM: 600040) apoptosis regulator BAX i ( 179) 192 52.9 3.4e-07 NP_001278358 (OMIM: 600040) apoptosis regulator BA ( 181) 192 52.9 3.5e-07 NP_001278357 (OMIM: 600040) apoptosis regulator BA ( 221) 192 53.0 4.1e-07 NP_001182 (OMIM: 600039) bcl-2-like protein 1 isof ( 170) 190 52.4 4.6e-07 NP_001278360 (OMIM: 600040) apoptosis regulator BA ( 114) 184 50.9 8.8e-07 NP_620118 (OMIM: 600040) apoptosis regulator BAX i ( 143) 184 51.0 1.1e-06 NP_001278359 (OMIM: 600040) apoptosis regulator BA ( 140) 178 49.6 2.7e-06 NP_115904 (OMIM: 605404) bcl-2-related ovarian kil ( 212) 175 49.0 6.2e-06 XP_011509998 (OMIM: 605404) PREDICTED: bcl-2-relat ( 212) 175 49.0 6.2e-06 NP_001108207 (OMIM: 601056) bcl-2-related protein ( 163) 168 47.3 1.6e-05 NP_004040 (OMIM: 601056) bcl-2-related protein A1 ( 175) 166 46.8 2.3e-05 XP_016860265 (OMIM: 605404) PREDICTED: bcl-2-relat ( 134) 151 43.2 0.00021 XP_016860264 (OMIM: 605404) PREDICTED: bcl-2-relat ( 134) 151 43.2 0.00021 NP_001184249 (OMIM: 159552) induced myeloid leukem ( 197) 148 42.6 0.00047 NP_068779 (OMIM: 159552) induced myeloid leukemia ( 350) 148 42.8 0.00075 >>NP_004041 (OMIM: 601931) bcl-2-like protein 2 [Homo sa (193 aa) initn: 1296 init1: 1296 opt: 1296 Z-score: 1647.9 bits: 311.7 E(85289): 4.7e-85 Smith-Waterman score: 1296; 100.0% identity (100.0% similar) in 193 aa overlap (1-193:1-193) 10 20 30 40 50 60 pF1KSD MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD FSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 FSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD QVQEWMVAYLETRLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QVQEWMVAYLETRLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVAL 130 140 150 160 170 180 190 pF1KSD GALVTVGAFFASK ::::::::::::: NP_004 GALVTVGAFFASK 190 >>NP_001186768 (OMIM: 601931) bcl-2-like protein 2 [Homo (193 aa) initn: 1296 init1: 1296 opt: 1296 Z-score: 1647.9 bits: 311.7 E(85289): 4.7e-85 Smith-Waterman score: 1296; 100.0% identity (100.0% similar) in 193 aa overlap (1-193:1-193) 10 20 30 40 50 60 pF1KSD MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD FSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD QVQEWMVAYLETRLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QVQEWMVAYLETRLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVAL 130 140 150 160 170 180 190 pF1KSD GALVTVGAFFASK ::::::::::::: NP_001 GALVTVGAFFASK 190 >>XP_016883482 (OMIM: 600039) PREDICTED: bcl-2-like prot (233 aa) initn: 594 init1: 506 opt: 530 Z-score: 676.5 bits: 132.2 E(85289): 6.1e-31 Smith-Waterman score: 530; 51.7% identity (77.5% similar) in 151 aa overlap (37-185:82-231) 10 20 30 40 50 60 pF1KSD APDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAA : : ..::.: :::::: :.::.::::.. XP_016 NGNPSWHLADSPAVNGATGHSSSLDAREVIPMA-AVKQALREAGDEFELRYRRAFSDLTS 60 70 80 90 100 110 70 80 90 100 110 120 pF1KSD QLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWM :::.:::.: : : :: .:::. : ::::.:::: ::.:::.:::.:::. ::... :: XP_016 QLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWM 120 130 140 150 160 170 130 140 150 160 170 180 pF1KSD VAYLETRLADWIHSSGGWAEFTALYGDGALEEARRLRE--GNWASVRTVLTGAVALGALV ..::. .: ::. .::: :. :::..: :.:. .: . : . ...:.: ::.: XP_016 ATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLF 180 190 200 210 220 230 190 pF1KSD TVGAFFASK . XP_016 SRK >>NP_001309169 (OMIM: 600039) bcl-2-like protein 1 isofo (233 aa) initn: 594 init1: 506 opt: 530 Z-score: 676.5 bits: 132.2 E(85289): 6.1e-31 Smith-Waterman score: 530; 51.7% identity (77.5% similar) in 151 aa overlap (37-185:82-231) 10 20 30 40 50 60 pF1KSD APDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAA : : ..::.: :::::: :.::.::::.. NP_001 NGNPSWHLADSPAVNGATGHSSSLDAREVIPMA-AVKQALREAGDEFELRYRRAFSDLTS 60 70 80 90 100 110 70 80 90 100 110 120 pF1KSD QLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWM :::.:::.: : : :: .:::. : ::::.:::: ::.:::.:::.:::. ::... :: NP_001 QLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWM 120 130 140 150 160 170 130 140 150 160 170 180 pF1KSD VAYLETRLADWIHSSGGWAEFTALYGDGALEEARRLRE--GNWASVRTVLTGAVALGALV ..::. .: ::. .::: :. :::..: :.:. .: . : . ...:.: ::.: NP_001 ATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLF 180 190 200 210 220 230 190 pF1KSD TVGAFFASK . NP_001 SRK >>NP_001304848 (OMIM: 600039) bcl-2-like protein 1 isofo (233 aa) initn: 594 init1: 506 opt: 530 Z-score: 676.5 bits: 132.2 E(85289): 6.1e-31 Smith-Waterman score: 530; 51.7% identity (77.5% similar) in 151 aa overlap (37-185:82-231) 10 20 30 40 50 60 pF1KSD APDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAA : : ..::.: :::::: :.::.::::.. NP_001 NGNPSWHLADSPAVNGATGHSSSLDAREVIPMA-AVKQALREAGDEFELRYRRAFSDLTS 60 70 80 90 100 110 70 80 90 100 110 120 pF1KSD QLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWM :::.:::.: : : :: .:::. : ::::.:::: ::.:::.:::.:::. ::... :: NP_001 QLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWM 120 130 140 150 160 170 130 140 150 160 170 180 pF1KSD VAYLETRLADWIHSSGGWAEFTALYGDGALEEARRLRE--GNWASVRTVLTGAVALGALV ..::. .: ::. .::: :. :::..: :.:. .: . : . ...:.: ::.: NP_001 ATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLF 180 190 200 210 220 230 190 pF1KSD TVGAFFASK . NP_001 SRK >>NP_001309168 (OMIM: 600039) bcl-2-like protein 1 isofo (233 aa) initn: 594 init1: 506 opt: 530 Z-score: 676.5 bits: 132.2 E(85289): 6.1e-31 Smith-Waterman score: 530; 51.7% identity (77.5% similar) in 151 aa overlap (37-185:82-231) 10 20 30 40 50 60 pF1KSD APDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAA : : ..::.: :::::: :.::.::::.. NP_001 NGNPSWHLADSPAVNGATGHSSSLDAREVIPMA-AVKQALREAGDEFELRYRRAFSDLTS 60 70 80 90 100 110 70 80 90 100 110 120 pF1KSD QLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWM :::.:::.: : : :: .:::. : ::::.:::: ::.:::.:::.:::. ::... :: NP_001 QLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWM 120 130 140 150 160 170 130 140 150 160 170 180 pF1KSD VAYLETRLADWIHSSGGWAEFTALYGDGALEEARRLRE--GNWASVRTVLTGAVALGALV ..::. .: ::. .::: :. :::..: :.:. .: . : . ...:.: ::.: NP_001 ATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLF 180 190 200 210 220 230 190 pF1KSD TVGAFFASK . NP_001 SRK >>NP_001304849 (OMIM: 600039) bcl-2-like protein 1 isofo (233 aa) initn: 594 init1: 506 opt: 530 Z-score: 676.5 bits: 132.2 E(85289): 6.1e-31 Smith-Waterman score: 530; 51.7% identity (77.5% similar) in 151 aa overlap (37-185:82-231) 10 20 30 40 50 60 pF1KSD APDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAA : : ..::.: :::::: :.::.::::.. NP_001 NGNPSWHLADSPAVNGATGHSSSLDAREVIPMA-AVKQALREAGDEFELRYRRAFSDLTS 60 70 80 90 100 110 70 80 90 100 110 120 pF1KSD QLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWM :::.:::.: : : :: .:::. : ::::.:::: ::.:::.:::.:::. ::... :: NP_001 QLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWM 120 130 140 150 160 170 130 140 150 160 170 180 pF1KSD VAYLETRLADWIHSSGGWAEFTALYGDGALEEARRLRE--GNWASVRTVLTGAVALGALV ..::. .: ::. .::: :. :::..: :.:. .: . : . ...:.: ::.: NP_001 ATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLF 180 190 200 210 220 230 190 pF1KSD TVGAFFASK . NP_001 SRK >>NP_001304850 (OMIM: 600039) bcl-2-like protein 1 isofo (233 aa) initn: 594 init1: 506 opt: 530 Z-score: 676.5 bits: 132.2 E(85289): 6.1e-31 Smith-Waterman score: 530; 51.7% identity (77.5% similar) in 151 aa overlap (37-185:82-231) 10 20 30 40 50 60 pF1KSD APDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAA : : ..::.: :::::: :.::.::::.. NP_001 NGNPSWHLADSPAVNGATGHSSSLDAREVIPMA-AVKQALREAGDEFELRYRRAFSDLTS 60 70 80 90 100 110 70 80 90 100 110 120 pF1KSD QLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWM :::.:::.: : : :: .:::. : ::::.:::: ::.:::.:::.:::. ::... :: NP_001 QLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWM 120 130 140 150 160 170 130 140 150 160 170 180 pF1KSD VAYLETRLADWIHSSGGWAEFTALYGDGALEEARRLRE--GNWASVRTVLTGAVALGALV ..::. .: ::. .::: :. :::..: :.:. .: . : . ...:.: ::.: NP_001 ATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLF 180 190 200 210 220 230 190 pF1KSD TVGAFFASK . NP_001 SRK >>XP_011527266 (OMIM: 600039) PREDICTED: bcl-2-like prot (233 aa) initn: 594 init1: 506 opt: 530 Z-score: 676.5 bits: 132.2 E(85289): 6.1e-31 Smith-Waterman score: 530; 51.7% identity (77.5% similar) in 151 aa overlap (37-185:82-231) 10 20 30 40 50 60 pF1KSD APDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAA : : ..::.: :::::: :.::.::::.. XP_011 NGNPSWHLADSPAVNGATGHSSSLDAREVIPMA-AVKQALREAGDEFELRYRRAFSDLTS 60 70 80 90 100 110 70 80 90 100 110 120 pF1KSD QLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWM :::.:::.: : : :: .:::. : ::::.:::: ::.:::.:::.:::. ::... :: XP_011 QLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWM 120 130 140 150 160 170 130 140 150 160 170 180 pF1KSD VAYLETRLADWIHSSGGWAEFTALYGDGALEEARRLRE--GNWASVRTVLTGAVALGALV ..::. .: ::. .::: :. :::..: :.:. .: . : . ...:.: ::.: XP_011 ATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLF 180 190 200 210 220 230 190 pF1KSD TVGAFFASK . XP_011 SRK >>NP_612815 (OMIM: 600039) bcl-2-like protein 1 isoform (233 aa) initn: 594 init1: 506 opt: 530 Z-score: 676.5 bits: 132.2 E(85289): 6.1e-31 Smith-Waterman score: 530; 51.7% identity (77.5% similar) in 151 aa overlap (37-185:82-231) 10 20 30 40 50 60 pF1KSD APDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAA : : ..::.: :::::: :.::.::::.. NP_612 NGNPSWHLADSPAVNGATGHSSSLDAREVIPMA-AVKQALREAGDEFELRYRRAFSDLTS 60 70 80 90 100 110 70 80 90 100 110 120 pF1KSD QLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWM :::.:::.: : : :: .:::. : ::::.:::: ::.:::.:::.:::. ::... :: NP_612 QLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWM 120 130 140 150 160 170 130 140 150 160 170 180 pF1KSD VAYLETRLADWIHSSGGWAEFTALYGDGALEEARRLRE--GNWASVRTVLTGAVALGALV ..::. .: ::. .::: :. :::..: :.:. .: . : . ...:.: ::.: NP_612 ATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLF 180 190 200 210 220 230 190 pF1KSD TVGAFFASK . NP_612 SRK 193 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 01:00:37 2016 done: Thu Nov 3 01:00:38 2016 Total Scan time: 4.090 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]