FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0280, 244 aa 1>>>pF1KSDA0280 244 - 244 aa - 244 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.5807+/-0.000368; mu= -3.8456+/- 0.023 mean_var=245.4165+/-51.644, 0's: 0 Z-trim(121.4): 12 B-trim: 735 in 1/58 Lambda= 0.081870 statistics sampled from 38000 (38014) to 38000 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.758), E-opt: 0.2 (0.446), width: 16 Scan time: 4.600 The best scores are: opt bits E(85289) NP_001272979 (OMIM: 616316) protein FAM168A isofor ( 244) 1695 212.3 6.3e-55 NP_055974 (OMIM: 616316) protein FAM168A isoform 2 ( 235) 1341 170.5 2.4e-42 XP_016872904 (OMIM: 616316) PREDICTED: protein FAM ( 193) 992 129.2 5.2e-30 XP_016872905 (OMIM: 616316) PREDICTED: protein FAM ( 138) 725 97.5 1.2e-20 NP_001272980 (OMIM: 616316) protein FAM168A isofor ( 129) 366 55.1 6.8e-08 >>NP_001272979 (OMIM: 616316) protein FAM168A isoform 1 (244 aa) initn: 1695 init1: 1695 opt: 1695 Z-score: 1107.1 bits: 212.3 E(85289): 6.3e-55 Smith-Waterman score: 1695; 100.0% identity (100.0% similar) in 244 aa overlap (1-244:1-244) 10 20 30 40 50 60 pF1KSD MNPVYSPVQPGAPYGNPKNMAYTGYPTAYPAAAPAYNPSLYPTNSPSYAPEFQFLHSAYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNPVYSPVQPGAPYGNPKNMAYTGYPTAYPAAAPAYNPSLYPTNSPSYAPEFQFLHSAYA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD TLLMKQAWPQNSSSCGTEGTFHLPVDTGTENRTYQASSAAFRYTAGTPYKVPPTQSNTAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLLMKQAWPQNSSSCGTEGTFHLPVDTGTENRTYQASSAAFRYTAGTPYKVPPTQSNTAP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD PPYSPSPNPYQTAMYPIRSAYPQQNLYAQGAYYTQPVYAAQPHVIHHTTVVQPNSIPSAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPYSPSPNPYQTAMYPIRSAYPQQNLYAQGAYYTQPVYAAQPHVIHHTTVVQPNSIPSAI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD YPAPVAAPRTNGVAMGMVAGTTMAMSAGTLLTTPQHTAIGAHPVSMPTYRAQGTPAYSYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YPAPVAAPRTNGVAMGMVAGTTMAMSAGTLLTTPQHTAIGAHPVSMPTYRAQGTPAYSYV 190 200 210 220 230 240 pF1KSD PPHW :::: NP_001 PPHW >>NP_055974 (OMIM: 616316) protein FAM168A isoform 2 [Ho (235 aa) initn: 1275 init1: 1275 opt: 1341 Z-score: 881.4 bits: 170.5 E(85289): 2.4e-42 Smith-Waterman score: 1605; 96.3% identity (96.3% similar) in 244 aa overlap (1-244:1-235) 10 20 30 40 50 60 pF1KSD MNPVYSPVQPGAPYGNPKNMAYTGYPTAYPAAAPAYNPSLYPTNSPSYAPEFQFLHSAYA :::::::::::::::::::::::::::::::::::::::::::::::::: : NP_055 MNPVYSPVQPGAPYGNPKNMAYTGYPTAYPAAAPAYNPSLYPTNSPSYAP---------A 10 20 30 40 50 70 80 90 100 110 120 pF1KSD TLLMKQAWPQNSSSCGTEGTFHLPVDTGTENRTYQASSAAFRYTAGTPYKVPPTQSNTAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 TLLMKQAWPQNSSSCGTEGTFHLPVDTGTENRTYQASSAAFRYTAGTPYKVPPTQSNTAP 60 70 80 90 100 110 130 140 150 160 170 180 pF1KSD PPYSPSPNPYQTAMYPIRSAYPQQNLYAQGAYYTQPVYAAQPHVIHHTTVVQPNSIPSAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PPYSPSPNPYQTAMYPIRSAYPQQNLYAQGAYYTQPVYAAQPHVIHHTTVVQPNSIPSAI 120 130 140 150 160 170 190 200 210 220 230 240 pF1KSD YPAPVAAPRTNGVAMGMVAGTTMAMSAGTLLTTPQHTAIGAHPVSMPTYRAQGTPAYSYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 YPAPVAAPRTNGVAMGMVAGTTMAMSAGTLLTTPQHTAIGAHPVSMPTYRAQGTPAYSYV 180 190 200 210 220 230 pF1KSD PPHW :::: NP_055 PPHW >>XP_016872904 (OMIM: 616316) PREDICTED: protein FAM168A (193 aa) initn: 1091 init1: 985 opt: 992 Z-score: 659.8 bits: 129.2 E(85289): 5.2e-30 Smith-Waterman score: 1231; 79.1% identity (79.1% similar) in 244 aa overlap (1-244:1-193) 10 20 30 40 50 60 pF1KSD MNPVYSPVQPGAPYGNPKNMAYTGYPTAYPAAAPAYNPSLYPTNSPSYAPEFQFLHSAYA :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MNPVYSPVQPGAPYGNPKNMAYTGYPTAYPAAAPAYNPSLYPTNSPSYAP---------- 10 20 30 40 50 70 80 90 100 110 120 pF1KSD TLLMKQAWPQNSSSCGTEGTFHLPVDTGTENRTYQASSAAFRYTAGTPYKVPPTQSNTAP : :::::::::::::::::: XP_016 ---------------G--------------------------YTAGTPYKVPPTQSNTAP 60 130 140 150 160 170 180 pF1KSD PPYSPSPNPYQTAMYPIRSAYPQQNLYAQGAYYTQPVYAAQPHVIHHTTVVQPNSIPSAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPYSPSPNPYQTAMYPIRSAYPQQNLYAQGAYYTQPVYAAQPHVIHHTTVVQPNSIPSAI 70 80 90 100 110 120 190 200 210 220 230 240 pF1KSD YPAPVAAPRTNGVAMGMVAGTTMAMSAGTLLTTPQHTAIGAHPVSMPTYRAQGTPAYSYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YPAPVAAPRTNGVAMGMVAGTTMAMSAGTLLTTPQHTAIGAHPVSMPTYRAQGTPAYSYV 130 140 150 160 170 180 pF1KSD PPHW :::: XP_016 PPHW 190 >>XP_016872905 (OMIM: 616316) PREDICTED: protein FAM168A (138 aa) initn: 710 init1: 710 opt: 725 Z-score: 491.4 bits: 97.5 E(85289): 1.2e-20 Smith-Waterman score: 739; 56.1% identity (56.6% similar) in 244 aa overlap (1-244:1-138) 10 20 30 40 50 60 pF1KSD MNPVYSPVQPGAPYGNPKNMAYTGYPTAYPAAAPAYNPSLYPTNSPSYAPEFQFLHSAYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MNPVYSPVQPGAPYGNPKNMAYTGYPTAYPAAAPAYNPSLYPTNSPSYAPEFQFLHSAYA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD TLLMKQAWPQNSSSCGTEGTFHLPVDTGTENRTYQASSAAFRYTAGTPYKVPPTQSNTAP ::::::::::::::::::::::::::::::::::::::::: XP_016 TLLMKQAWPQNSSSCGTEGTFHLPVDTGTENRTYQASSAAF------------------- 70 80 90 100 130 140 150 160 170 180 pF1KSD PPYSPSPNPYQTAMYPIRSAYPQQNLYAQGAYYTQPVYAAQPHVIHHTTVVQPNSIPSAI XP_016 ------------------------------------------------------------ 190 200 210 220 230 240 pF1KSD YPAPVAAPRTNGVAMGMVAGTTMAMSAGTLLTTPQHTAIGAHPVSMPTYRAQGTPAYSYV .:::::::::::::::::::::::::::::::: XP_016 ---------------------------STLLTTPQHTAIGAHPVSMPTYRAQGTPAYSYV 110 120 130 pF1KSD PPHW :::: XP_016 PPHW >>NP_001272980 (OMIM: 616316) protein FAM168A isoform 3 (129 aa) initn: 610 init1: 366 opt: 366 Z-score: 262.7 bits: 55.1 E(85289): 6.8e-08 Smith-Waterman score: 649; 52.5% identity (52.9% similar) in 244 aa overlap (1-244:1-129) 10 20 30 40 50 60 pF1KSD MNPVYSPVQPGAPYGNPKNMAYTGYPTAYPAAAPAYNPSLYPTNSPSYAPEFQFLHSAYA :::::::::::::::::::::::::::::::::::::::::::::::::: : NP_001 MNPVYSPVQPGAPYGNPKNMAYTGYPTAYPAAAPAYNPSLYPTNSPSYAP---------A 10 20 30 40 50 70 80 90 100 110 120 pF1KSD TLLMKQAWPQNSSSCGTEGTFHLPVDTGTENRTYQASSAAFRYTAGTPYKVPPTQSNTAP ::::::::::::::::::::::::::::::::::::::::: NP_001 TLLMKQAWPQNSSSCGTEGTFHLPVDTGTENRTYQASSAAF------------------- 60 70 80 90 130 140 150 160 170 180 pF1KSD PPYSPSPNPYQTAMYPIRSAYPQQNLYAQGAYYTQPVYAAQPHVIHHTTVVQPNSIPSAI NP_001 ------------------------------------------------------------ 190 200 210 220 230 240 pF1KSD YPAPVAAPRTNGVAMGMVAGTTMAMSAGTLLTTPQHTAIGAHPVSMPTYRAQGTPAYSYV .:::::::::::::::::::::::::::::::: NP_001 ---------------------------STLLTTPQHTAIGAHPVSMPTYRAQGTPAYSYV 100 110 120 pF1KSD PPHW :::: NP_001 PPHW 244 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 01:05:36 2016 done: Thu Nov 3 01:05:37 2016 Total Scan time: 4.600 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]