FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0282, 664 aa 1>>>pF1KSDA0282 664 - 664 aa - 664 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.2280+/-0.000396; mu= 7.0013+/- 0.025 mean_var=188.0698+/-39.441, 0's: 0 Z-trim(118.9): 138 B-trim: 702 in 1/54 Lambda= 0.093522 statistics sampled from 32108 (32262) to 32108 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.717), E-opt: 0.2 (0.378), width: 16 Scan time: 10.900 The best scores are: opt bits E(85289) NP_055978 (OMIM: 606555) E3 ubiquitin-protein liga ( 710) 4566 628.9 1.9e-179 XP_016876434 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 710) 4566 628.9 1.9e-179 XP_016876435 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 706) 4523 623.1 1.1e-177 XP_016876436 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 692) 4275 589.6 1.2e-167 XP_016876437 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 688) 4232 583.8 6.9e-166 XP_005267359 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 714) 3808 526.6 1.2e-148 NP_443210 (OMIM: 606555) E3 ubiquitin-protein liga ( 550) 3691 510.8 5.5e-144 XP_016876433 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 732) 3692 511.0 6.2e-144 XP_005267358 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 777) 3691 510.9 7.1e-144 XP_006720081 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 795) 3691 510.9 7.2e-144 XP_016876432 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 791) 3648 505.1 4e-142 XP_011534691 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 802) 3648 505.1 4.1e-142 XP_016876439 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 593) 3027 421.2 5.4e-117 XP_016876438 (OMIM: 606555) PREDICTED: E3 ubiquiti ( 611) 3027 421.2 5.5e-117 NP_001287818 (OMIM: 610584) tripartite motif-conta ( 721) 2411 338.2 6.5e-92 NP_001004342 (OMIM: 610584) tripartite motif-conta ( 783) 2387 334.9 6.6e-91 XP_016856812 (OMIM: 610584) PREDICTED: tripartite ( 854) 2387 335.0 7e-91 XP_011542494 (OMIM: 610584) PREDICTED: tripartite ( 781) 2381 334.1 1.2e-90 NP_001287688 (OMIM: 609317) E3 ubiquitin-protein l ( 716) 610 95.2 9.2e-19 NP_061170 (OMIM: 609317) E3 ubiquitin-protein liga ( 728) 610 95.2 9.3e-19 XP_016865111 (OMIM: 609317) PREDICTED: E3 ubiquiti ( 733) 607 94.8 1.2e-18 XP_016865110 (OMIM: 609317) PREDICTED: E3 ubiquiti ( 745) 607 94.8 1.3e-18 XP_016865112 (OMIM: 609317) PREDICTED: E3 ubiquiti ( 529) 596 93.2 2.7e-18 XP_016884728 (OMIM: 300204,300928) PREDICTED: prob ( 685) 562 88.7 7.9e-17 NP_438112 (OMIM: 300204,300928) probable E3 ubiqui ( 705) 562 88.7 8.1e-17 XP_016885029 (OMIM: 189960,300000,300552) PREDICTE ( 552) 558 88.1 9.7e-17 NP_000372 (OMIM: 189960,300000,300552) E3 ubiquiti ( 667) 558 88.1 1.1e-16 NP_001092094 (OMIM: 189960,300000,300552) E3 ubiqu ( 667) 558 88.1 1.1e-16 XP_016885025 (OMIM: 189960,300000,300552) PREDICTE ( 667) 558 88.1 1.1e-16 NP_001180206 (OMIM: 189960,300000,300552) E3 ubiqu ( 667) 558 88.1 1.1e-16 NP_150632 (OMIM: 189960,300000,300552) E3 ubiquiti ( 667) 558 88.1 1.1e-16 XP_005262119 (OMIM: 300204,300928) PREDICTED: prob ( 715) 507 81.3 1.4e-14 NP_036348 (OMIM: 300204,300928) probable E3 ubiqui ( 735) 507 81.3 1.4e-14 NP_001287681 (OMIM: 609317) E3 ubiquitin-protein l ( 573) 487 78.5 7.7e-14 NP_001180208 (OMIM: 189960,300000,300552) E3 ubiqu ( 489) 482 77.8 1.1e-13 XP_016885031 (OMIM: 189960,300000,300552) PREDICTE ( 489) 482 77.8 1.1e-13 XP_011543828 (OMIM: 189960,300000,300552) PREDICTE ( 718) 419 69.4 5.3e-11 XP_006724555 (OMIM: 189960,300000,300552) PREDICTE ( 718) 419 69.4 5.3e-11 XP_016885023 (OMIM: 189960,300000,300552) PREDICTE ( 718) 419 69.4 5.3e-11 XP_011543829 (OMIM: 189960,300000,300552) PREDICTE ( 718) 419 69.4 5.3e-11 XP_005274594 (OMIM: 189960,300000,300552) PREDICTE ( 718) 419 69.4 5.3e-11 XP_011543827 (OMIM: 189960,300000,300552) PREDICTE ( 718) 419 69.4 5.3e-11 XP_005274593 (OMIM: 189960,300000,300552) PREDICTE ( 718) 419 69.4 5.3e-11 NP_001269307 (OMIM: 600986) tripartite motif-conta ( 633) 402 67.1 2.3e-10 XP_016885030 (OMIM: 189960,300000,300552) PREDICTE ( 540) 342 58.9 5.7e-08 NP_001180207 (OMIM: 189960,300000,300552) E3 ubiqu ( 540) 342 58.9 5.7e-08 NP_997279 (OMIM: 616923) RING finger protein 207 [ ( 634) 315 55.3 8e-07 XP_016856748 (OMIM: 616923) PREDICTED: RING finger ( 656) 315 55.3 8.2e-07 NP_115977 (OMIM: 606131) E3 ubiquitin-protein liga ( 353) 296 52.6 3e-06 XP_016858048 (OMIM: 606131) PREDICTED: E3 ubiquiti ( 379) 296 52.6 3.2e-06 >>NP_055978 (OMIM: 606555) E3 ubiquitin-protein ligase T (710 aa) initn: 4566 init1: 4566 opt: 4566 Z-score: 3342.6 bits: 628.9 E(85289): 1.9e-179 Smith-Waterman score: 4566; 99.8% identity (100.0% similar) in 661 aa overlap (1-661:1-661) 10 20 30 40 50 60 pF1KSD MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD PRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD CVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 CVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD MVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD RQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD DGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEVAWFAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEVAWFAF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD DPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVAR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD MDVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDFNRKNLTF ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::: NP_055 MDVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKNLTF 610 620 630 640 650 660 pF1KSD FYQR : NP_055 FINDEQQGPIAFDNVEGLFFPAVSLNRNVQVTLHTGLPVPDFYSSRASIA 670 680 690 700 710 >>XP_016876434 (OMIM: 606555) PREDICTED: E3 ubiquitin-pr (710 aa) initn: 4566 init1: 4566 opt: 4566 Z-score: 3342.6 bits: 628.9 E(85289): 1.9e-179 Smith-Waterman score: 4566; 99.8% identity (100.0% similar) in 661 aa overlap (1-661:1-661) 10 20 30 40 50 60 pF1KSD MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD PRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD CVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD MVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD RQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD DGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEVAWFAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEVAWFAF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD DPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVAR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD MDVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDFNRKNLTF ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::: XP_016 MDVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKNLTF 610 620 630 640 650 660 pF1KSD FYQR : XP_016 FINDEQQGPIAFDNVEGLFFPAVSLNRNVQVTLHTGLPVPDFYSSRASIA 670 680 690 700 710 >>XP_016876435 (OMIM: 606555) PREDICTED: E3 ubiquitin-pr (706 aa) initn: 4527 init1: 3026 opt: 4523 Z-score: 3311.2 bits: 623.1 E(85289): 1.1e-177 Smith-Waterman score: 4523; 99.2% identity (99.4% similar) in 661 aa overlap (1-661:1-657) 10 20 30 40 50 60 pF1KSD MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD PRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD CVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD MVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD RQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELD ::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_016 PLLQSIHQLDFVQVK----VPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELD 430 440 450 460 470 490 500 510 520 530 540 pF1KSD DGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEVAWFAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEVAWFAF 480 490 500 510 520 530 550 560 570 580 590 600 pF1KSD DPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVAR 540 550 560 570 580 590 610 620 630 640 650 660 pF1KSD MDVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDFNRKNLTF ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::: XP_016 MDVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKNLTF 600 610 620 630 640 650 pF1KSD FYQR : XP_016 FINDEQQGPIAFDNVEGLFFPAVSLNRNVQVTLHTGLPVPDFYSSRASIA 660 670 680 690 700 >>XP_016876436 (OMIM: 606555) PREDICTED: E3 ubiquitin-pr (692 aa) initn: 4442 init1: 4275 opt: 4275 Z-score: 3130.5 bits: 589.6 E(85289): 1.2e-167 Smith-Waterman score: 4380; 97.0% identity (97.3% similar) in 661 aa overlap (1-661:1-643) 10 20 30 40 50 60 pF1KSD MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD PRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD CVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD MVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD RQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD DGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEVAWFAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEVAWFAF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD DPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVAR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD MDVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDFNRKNLTF :::::::::::::::::. ::::::::::::::::.::::::: XP_016 MDVMKDVMLGKDDKAWAI------------------TEGGITKGATIGVLLDLNRKNLTF 610 620 630 640 pF1KSD FYQR : XP_016 FINDEQQGPIAFDNVEGLFFPAVSLNRNVQVTLHTGLPVPDFYSSRASIA 650 660 670 680 690 >>XP_016876437 (OMIM: 606555) PREDICTED: E3 ubiquitin-pr (688 aa) initn: 4373 init1: 3026 opt: 4232 Z-score: 3099.2 bits: 583.8 E(85289): 6.9e-166 Smith-Waterman score: 4337; 96.4% identity (96.7% similar) in 661 aa overlap (1-661:1-639) 10 20 30 40 50 60 pF1KSD MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD PRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD CVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD MVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD RQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELD ::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_016 PLLQSIHQLDFVQVK----VPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELD 430 440 450 460 470 490 500 510 520 530 540 pF1KSD DGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEVAWFAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEVAWFAF 480 490 500 510 520 530 550 560 570 580 590 600 pF1KSD DPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVAR 540 550 560 570 580 590 610 620 630 640 650 660 pF1KSD MDVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDFNRKNLTF :::::::::::::::::. ::::::::::::::::.::::::: XP_016 MDVMKDVMLGKDDKAWAI------------------TEGGITKGATIGVLLDLNRKNLTF 600 610 620 630 pF1KSD FYQR : XP_016 FINDEQQGPIAFDNVEGLFFPAVSLNRNVQVTLHTGLPVPDFYSSRASIA 640 650 660 670 680 >>XP_005267359 (OMIM: 606555) PREDICTED: E3 ubiquitin-pr (714 aa) initn: 4398 init1: 3691 opt: 3808 Z-score: 2789.8 bits: 526.6 E(85289): 1.2e-148 Smith-Waterman score: 4326; 93.9% identity (94.1% similar) in 683 aa overlap (1-661:1-665) 10 20 30 40 50 60 pF1KSD MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD PRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD CVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD MVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD RQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELD 430 440 450 460 470 480 490 500 510 520 530 pF1KSD DGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSE------ :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEGCNFET 490 500 510 520 530 540 540 550 560 570 pF1KSD ----------------VAWFAFDPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGI :::::::::::::::::::::::::::::::::::::::::::: XP_005 QSAPYSQLVDIKKLLAVAWFAFDPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGI 550 560 570 580 590 600 580 590 600 610 620 630 pF1KSD HYWELTVDRYDNHPDPAFGVARMDVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTE :::::::::::::::::::::::::::::::::::::::. :: XP_005 HYWELTVDRYDNHPDPAFGVARMDVMKDVMLGKDDKAWAI------------------TE 610 620 630 640 640 650 660 pF1KSD GGITKGATIGVLLDFNRKNLTFFYQR ::::::::::::::.:::::::: XP_005 GGITKGATIGVLLDLNRKNLTFFINDEQQGPIAFDNVEGLFFPAVSLNRNVQVTLHTGLP 650 660 670 680 690 700 >>NP_443210 (OMIM: 606555) E3 ubiquitin-protein ligase T (550 aa) initn: 3691 init1: 3691 opt: 3691 Z-score: 2706.1 bits: 510.8 E(85289): 5.5e-144 Smith-Waterman score: 3691; 100.0% identity (100.0% similar) in 534 aa overlap (1-534:1-534) 10 20 30 40 50 60 pF1KSD MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 DYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD PRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 PRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 MCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD CVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 CVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD MVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 MVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD RQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 RQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 PLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD DGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEVAWFAF :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 DGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEGKALQQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD DPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVAR NP_443 YPSERELRGI 550 >>XP_016876433 (OMIM: 606555) PREDICTED: E3 ubiquitin-pr (732 aa) initn: 4552 init1: 3691 opt: 3692 Z-score: 2705.1 bits: 511.0 E(85289): 6.2e-144 Smith-Waterman score: 4512; 96.6% identity (96.8% similar) in 683 aa overlap (1-661:1-683) 10 20 30 40 50 60 pF1KSD MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD PRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD CVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD MVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD RQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELD 430 440 450 460 470 480 490 500 510 520 530 pF1KSD DGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSE------ :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEGCNFET 490 500 510 520 530 540 540 550 560 570 pF1KSD ----------------VAWFAFDPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGI :::::::::::::::::::::::::::::::::::::::::::: XP_016 QSAPYSQLVDIKKLLAVAWFAFDPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGI 550 560 570 580 590 600 580 590 600 610 620 630 pF1KSD HYWELTVDRYDNHPDPAFGVARMDVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HYWELTVDRYDNHPDPAFGVARMDVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTE 610 620 630 640 650 660 640 650 660 pF1KSD GGITKGATIGVLLDFNRKNLTFFYQR ::::::::::::::.:::::::: XP_016 GGITKGATIGVLLDLNRKNLTFFINDEQQGPIAFDNVEGLFFPAVSLNRNVQVTLHTGLP 670 680 690 700 710 720 >>XP_005267358 (OMIM: 606555) PREDICTED: E3 ubiquitin-pr (777 aa) initn: 4398 init1: 3691 opt: 3691 Z-score: 2704.0 bits: 510.9 E(85289): 7.1e-144 Smith-Waterman score: 4046; 87.8% identity (87.8% similar) in 696 aa overlap (1-611:1-696) 10 20 30 40 50 60 pF1KSD MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD PRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD CVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD MVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD RQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELD 430 440 450 460 470 480 490 500 510 520 530 pF1KSD DGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSE------ :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEDTDSEE 490 500 510 520 530 540 pF1KSD ------------------------------------------------------------ XP_005 QTLPFPVPSERLPLRRMSPFSSTLNLQPSFPGRSYFDFRSSPHQLSLHSSLQSLNAPGCN 550 560 570 580 590 600 540 550 560 570 pF1KSD -------------------VAWFAFDPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFS ::::::::::::::::::::::::::::::::::::::::: XP_005 FETQSAPYSQLVDIKKLLAVAWFAFDPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFS 610 620 630 640 650 660 580 590 600 610 620 630 pF1KSD KGIHYWELTVDRYDNHPDPAFGVARMDVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTN :::::::::::::::::::::::::::::::::::: XP_005 KGIHYWELTVDRYDNHPDPAFGVARMDVMKDVMLGKDDKAWAITEGGITKGATIGVLLDL 670 680 690 700 710 720 640 650 660 pF1KSD RTEGGITKGATIGVLLDFNRKNLTFFYQR XP_005 NRKNLTFFINDEQQGPIAFDNVEGLFFPAVSLNRNVQVTLHTGLPVPDFYSSRASIA 730 740 750 760 770 >>XP_006720081 (OMIM: 606555) PREDICTED: E3 ubiquitin-pr (795 aa) initn: 4552 init1: 3691 opt: 3691 Z-score: 2703.8 bits: 510.9 E(85289): 7.2e-144 Smith-Waterman score: 4046; 87.8% identity (87.8% similar) in 696 aa overlap (1-611:1-696) 10 20 30 40 50 60 pF1KSD MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD PRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD CVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD MVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD RQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELD 430 440 450 460 470 480 490 500 510 520 530 pF1KSD DGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSE------ :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEDTDSEE 490 500 510 520 530 540 pF1KSD ------------------------------------------------------------ XP_006 QTLPFPVPSERLPLRRMSPFSSTLNLQPSFPGRSYFDFRSSPHQLSLHSSLQSLNAPGCN 550 560 570 580 590 600 540 550 560 570 pF1KSD -------------------VAWFAFDPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFS ::::::::::::::::::::::::::::::::::::::::: XP_006 FETQSAPYSQLVDIKKLLAVAWFAFDPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFS 610 620 630 640 650 660 580 590 600 610 620 630 pF1KSD KGIHYWELTVDRYDNHPDPAFGVARMDVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTN :::::::::::::::::::::::::::::::::::: XP_006 KGIHYWELTVDRYDNHPDPAFGVARMDVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTN 670 680 690 700 710 720 640 650 660 pF1KSD RTEGGITKGATIGVLLDFNRKNLTFFYQR XP_006 RTEGGITKGATIGVLLDLNRKNLTFFINDEQQGPIAFDNVEGLFFPAVSLNRNVQVTLHT 730 740 750 760 770 780 >-- initn: 340 init1: 340 opt: 340 Z-score: 260.3 bits: 58.8 E(85289): 9.2e-08 Smith-Waterman score: 340; 98.0% identity (100.0% similar) in 50 aa overlap (612-661:697-746) 590 600 610 620 630 640 pF1KSD ELTVDRYDNHPDPAFGVARMDVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGI :::::::::::::::::::::::::::::: XP_006 ELTVDRYDNHPDPAFGVARMDVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGI 670 680 690 700 710 720 650 660 pF1KSD TKGATIGVLLDFNRKNLTFFYQR :::::::::::.:::::::: XP_006 TKGATIGVLLDLNRKNLTFFINDEQQGPIAFDNVEGLFFPAVSLNRNVQVTLHTGLPVPD 730 740 750 760 770 780 664 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 01:06:14 2016 done: Thu Nov 3 01:06:16 2016 Total Scan time: 10.900 Total Display time: 0.150 Function used was FASTA [36.3.4 Apr, 2011]