FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0479, 307 aa 1>>>pF1KSDA0479 307 - 307 aa - 307 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7073+/-0.000973; mu= 13.0842+/- 0.058 mean_var=62.4122+/-12.177, 0's: 0 Z-trim(104.3): 23 B-trim: 0 in 0/50 Lambda= 0.162345 statistics sampled from 7828 (7837) to 7828 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.618), E-opt: 0.2 (0.241), width: 16 Scan time: 2.170 The best scores are: opt bits E(32554) CCDS1353.1 NMNAT2 gene_id:23057|Hs108|chr1 ( 307) 2073 494.2 5.2e-140 CCDS1354.1 NMNAT2 gene_id:23057|Hs108|chr1 ( 302) 1890 451.4 4.1e-127 CCDS82846.1 NMNAT3 gene_id:349565|Hs108|chr3 ( 252) 435 110.6 1.3e-24 CCDS72698.1 NMNAT1 gene_id:64802|Hs108|chr1 ( 160) 426 108.4 3.7e-24 CCDS108.1 NMNAT1 gene_id:64802|Hs108|chr1 ( 279) 428 108.9 4.5e-24 CCDS3111.1 NMNAT3 gene_id:349565|Hs108|chr3 ( 215) 270 71.9 4.9e-13 >>CCDS1353.1 NMNAT2 gene_id:23057|Hs108|chr1 (307 aa) initn: 2073 init1: 2073 opt: 2073 Z-score: 2627.2 bits: 494.2 E(32554): 5.2e-140 Smith-Waterman score: 2073; 100.0% identity (100.0% similar) in 307 aa overlap (1-307:1-307) 10 20 30 40 50 60 pF1KSD MTETTKTHVILLACGSFNPITKGHIQMFERARDYLHKTGRFIVIGGIVSPVHDSYGKQGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 MTETTKTHVILLACGSFNPITKGHIQMFERARDYLHKTGRFIVIGGIVSPVHDSYGKQGL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD VSSRHRLIMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 VSSRHRLIMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD SMTPVIGQPQNETPQPIYQNSNVATKPTAAKILGKVGESLSRICCVRPPVERFTFVDENA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 SMTPVIGQPQNETPQPIYQNSNVATKPTAAKILGKVGESLSRICCVRPPVERFTFVDENA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD NLGTVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 NLGTVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD MNHSSILRKYKNNIMVVKDDINHPMSVVSSTKSRLALQHGDGHVVDYLSQPVIDYILKSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 MNHSSILRKYKNNIMVVKDDINHPMSVVSSTKSRLALQHGDGHVVDYLSQPVIDYILKSQ 250 260 270 280 290 300 pF1KSD LYINASG ::::::: CCDS13 LYINASG >>CCDS1354.1 NMNAT2 gene_id:23057|Hs108|chr1 (302 aa) initn: 1890 init1: 1890 opt: 1890 Z-score: 2395.7 bits: 451.4 E(32554): 4.1e-127 Smith-Waterman score: 1890; 98.6% identity (99.3% similar) in 283 aa overlap (25-307:20-302) 10 20 30 40 50 60 pF1KSD MTETTKTHVILLACGSFNPITKGHIQMFERARDYLHKTGRFIVIGGIVSPVHDSYGKQGL . . :::::::::::::::::::::::::::::::: CCDS13 MEIQELEEIQACQGLWEVFVTLSERARDYLHKTGRFIVIGGIVSPVHDSYGKQGL 10 20 30 40 50 70 80 90 100 110 120 pF1KSD VSSRHRLIMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 VSSRHRLIMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTP 60 70 80 90 100 110 130 140 150 160 170 180 pF1KSD SMTPVIGQPQNETPQPIYQNSNVATKPTAAKILGKVGESLSRICCVRPPVERFTFVDENA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 SMTPVIGQPQNETPQPIYQNSNVATKPTAAKILGKVGESLSRICCVRPPVERFTFVDENA 120 130 140 150 160 170 190 200 210 220 230 240 pF1KSD NLGTVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 NLGTVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRI 180 190 200 210 220 230 250 260 270 280 290 300 pF1KSD MNHSSILRKYKNNIMVVKDDINHPMSVVSSTKSRLALQHGDGHVVDYLSQPVIDYILKSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 MNHSSILRKYKNNIMVVKDDINHPMSVVSSTKSRLALQHGDGHVVDYLSQPVIDYILKSQ 240 250 260 270 280 290 pF1KSD LYINASG ::::::: CCDS13 LYINASG 300 >>CCDS82846.1 NMNAT3 gene_id:349565|Hs108|chr3 (252 aa) initn: 607 init1: 424 opt: 435 Z-score: 555.2 bits: 110.6 E(32554): 1.3e-24 Smith-Waterman score: 544; 37.3% identity (58.7% similar) in 303 aa overlap (5-306:3-237) 10 20 30 40 50 60 pF1KSD MTETTKTHVILLACGSFNPITKGHIQMFERARDYLHKTGRFIVIGGIVSPVHDSYGKQGL .. :.:::::::::::. :..::: :::.::.:: . :: ::.:::.:.:::. : CCDS82 MKSRIPVVLLACGSFNPITNMHLRMFEVARDHLHQTGMYQVIQGIISPVNDTYGKKDL 10 20 30 40 50 70 80 90 100 110 120 pF1KSD VSSRHRLIMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTP ..:.::. : .::.:.:::::::::: : :. : .::.::.. . : .: CCDS82 AASHHRVAMARLALQTSDWIRVDPWESEQAQWMETVKVLRHHHSKLLR----------SP 60 70 80 90 100 130 140 150 160 170 180 pF1KSD SMTPVIGQPQNETPQPIYQNSNVATKPTAAKILGKVGESLSRICCVRPPVERFTFVDENA :: : :. ... . . :.:. : CCDS82 --------PQMEGPD---HGKALFSTPAAV------------------P----------- 110 120 190 200 210 220 230 240 pF1KSD NLGTVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRI ::. ::::.:.:..: :.::..: .. :: ::.: : : . : CCDS82 -----------ELK--LLCGADVLKTFQTPNLWKDAHIQEIVEKFGLVCVGRVGHDPKGY 130 140 150 160 170 250 260 270 280 290 pF1KSD MNHSSILRKYKNNIMVVKDDINHPMSVVSSTKSRLALQHGDGHVVDYL-SQPVIDYILKS . .: ::: ...:: ..:. ... .:.: : :: :.:. : :: . :: :: CCDS82 IAESPILRMHQHNIHLAKEPVQNE---ISATYIRRAL--GQGQSVKYLIPDAVITYIKDH 180 190 200 210 220 230 300 pF1KSD QLYINASG :: ..: CCDS82 GLYTKGSTWKGKSTQSTEGKTS 240 250 >>CCDS72698.1 NMNAT1 gene_id:64802|Hs108|chr1 (160 aa) initn: 419 init1: 419 opt: 426 Z-score: 547.1 bits: 108.4 E(32554): 3.7e-24 Smith-Waterman score: 426; 47.5% identity (78.7% similar) in 122 aa overlap (1-122:1-120) 10 20 30 40 50 60 pF1KSD MTETTKTHVILLACGSFNPITKGHIQMFERARDYLHKTGRFIVIGGIVSPVHDSYGKQGL : .. ::.:.:::::::::::. :...:: :.::.. :::. :. ::.::: :.: :.:: CCDS72 MENSEKTEVVLLACGSFNPITNMHLRLFELAKDYMNGTGRYTVVKGIISPVGDAYKKKGL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD VSSRHRLIMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTP . . ::.:: .::..:: :..:: :: : :. : .::.::.. .. .. : .. :.: CCDS72 IPAYHRVIMAELATKNSKWVEVDTWESLQKEWKETLKVLRHHQEKLE-ASDCDHQQ-NSP 70 80 90 100 110 130 140 150 160 170 180 pF1KSD SMTPVIGQPQNETPQPIYQNSNVATKPTAAKILGKVGESLSRICCVRPPVERFTFVDENA .. CCDS72 TLERPGRKRKWTETQDSSQKKSLEPKTKDGVSLYHPGWSAVA 120 130 140 150 160 >>CCDS108.1 NMNAT1 gene_id:64802|Hs108|chr1 (279 aa) initn: 632 init1: 419 opt: 428 Z-score: 545.6 bits: 108.9 E(32554): 4.5e-24 Smith-Waterman score: 589; 36.0% identity (62.7% similar) in 308 aa overlap (1-306:1-258) 10 20 30 40 50 60 pF1KSD MTETTKTHVILLACGSFNPITKGHIQMFERARDYLHKTGRFIVIGGIVSPVHDSYGKQGL : .. ::.:.:::::::::::. :...:: :.::.. :::. :. ::.::: :.: :.:: CCDS10 MENSEKTEVVLLACGSFNPITNMHLRLFELAKDYMNGTGRYTVVKGIISPVGDAYKKKGL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD VSSRHRLIMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTP . . ::.:: .::..:: :..:: :: : :. : .::.::.. .. .. : .. :.: CCDS10 IPAYHRVIMAELATKNSKWVEVDTWESLQKEWKETLKVLRHHQEKLE-ASDCDHQQ-NSP 70 80 90 100 110 130 140 150 160 170 pF1KSD SMT-PVIGQPQNETPQPIYQNSNVATKPTAAKILGKVGESLSRICCVRPPVERFTFVDEN .. : . .:: : :.... : :. : :. CCDS10 TLERPGRKRKWTET-QDSSQKKSLEPKTKAV-----------------PKVK-------- 120 130 140 150 180 190 200 210 220 230 pF1KSD ANLGTVMRYEEIELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDR ::::.:::::: .:.::. :. ::...:.. : : . :... CCDS10 -----------------LLCGADLLESFAVPNLWKSEDITQIVANYGLICVTRAGNDAQK 160 170 180 190 240 250 260 270 280 290 pF1KSD IMNHSSILRKYKNNIMVVKDDINHPMSVVSSTKSRLALQHGDGHVVDYLSQPVI-DYILK .. .:..: :...:: ::.. : . .:::: : ::..:.. . :: .. .:: : CCDS10 FIYESDVLWKHRSNIHVVNEWIAND---ISSTKIRRALRRGQS--IRYLVPDLVQEYIEK 200 210 220 230 240 250 300 pF1KSD SQLYINASG .:: . : CCDS10 HNLYSSESEDRNAGVILAPLQRNTAEAKT 260 270 >>CCDS3111.1 NMNAT3 gene_id:349565|Hs108|chr3 (215 aa) initn: 452 init1: 269 opt: 270 Z-score: 347.5 bits: 71.9 E(32554): 4.9e-13 Smith-Waterman score: 379; 33.7% identity (55.1% similar) in 267 aa overlap (41-306:2-200) 20 30 40 50 60 70 pF1KSD LLACGSFNPITKGHIQMFERARDYLHKTGRFIVIGGIVSPVHDSYGKQGLVSSRHRLIMC . :: ::.:::.:.:::. :..:.::. : CCDS31 MYQVIQGIISPVNDTYGKKDLAASHHRVAMA 10 20 30 80 90 100 110 120 130 pF1KSD QLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTPSMTPVIGQPQ .::.:.:::::::::: : :. : .::.::.. . : .: :: CCDS31 RLALQTSDWIRVDPWESEQAQWMETVKVLRHHHSKLLR--------------SP----PQ 40 50 60 70 140 150 160 170 180 190 pF1KSD NETPQPIYQNSNVATKPTAAKILGKVGESLSRICCVRPPVERFTFVDENANLGTVMRYEE : :. ... . . :.:. : CCDS31 MEGPD---HGKALFSTPAAV-----------------P---------------------- 80 90 200 210 220 230 240 250 pF1KSD IELRILLLCGSDLLESFCIPGLWNEADMEVIVGDFGIVVVPRDAADTDRIMNHSSILRKY ::. ::::.:.:..: :.::..: .. :: ::.: : : . : . .: ::: . CCDS31 -ELK--LLCGADVLKTFQTPNLWKDAHIQEIVEKFGLVCVGRVGHDPKGYIAESPILRMH 100 110 120 130 140 260 270 280 290 300 pF1KSD KNNIMVVKDDINHPMSVVSSTKSRLALQHGDGHVVDYL-SQPVIDYILKSQLYINASG ..:: ..:. ... .:.: : :: :.:. : :: . :: :: :: ..: CCDS31 QHNIHLAKEPVQNE---ISATYIRRAL--GQGQSVKYLIPDAVITYIKDHGLYTKGSTWK 150 160 170 180 190 200 CCDS31 GKSTQSTEGKTS 210 307 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 01:52:41 2016 done: Thu Nov 3 01:52:41 2016 Total Scan time: 2.170 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]