FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0544, 552 aa 1>>>pF1KSDA0544 552 - 552 aa - 552 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.1566+/-0.000386; mu= 6.2178+/- 0.024 mean_var=197.2630+/-40.129, 0's: 0 Z-trim(118.8): 74 B-trim: 0 in 0/55 Lambda= 0.091317 statistics sampled from 31980 (32056) to 31980 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.728), E-opt: 0.2 (0.376), width: 16 Scan time: 9.930 The best scores are: opt bits E(85289) NP_001135762 (OMIM: 607559) E3 ubiquitin-protein l ( 552) 3718 502.7 1.2e-141 XP_005255277 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 552) 3718 502.7 1.2e-141 XP_016878580 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 553) 3706 501.1 3.7e-141 XP_005255276 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 553) 3706 501.1 3.7e-141 NP_056061 (OMIM: 607559) E3 ubiquitin-protein liga ( 576) 3627 490.7 5.2e-138 XP_005255274 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 577) 3615 489.1 1.6e-137 XP_016878582 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 514) 3464 469.2 1.4e-131 XP_011520743 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 539) 3361 455.6 1.8e-127 NP_001135763 (OMIM: 607559) E3 ubiquitin-protein l ( 530) 2462 337.2 7.8e-92 XP_005255278 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 530) 2462 337.2 7.8e-92 XP_016878581 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 531) 2450 335.6 2.3e-91 NP_001135761 (OMIM: 607559) E3 ubiquitin-protein l ( 554) 2442 334.6 5e-91 XP_005255275 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 555) 2430 333.0 1.5e-90 XP_011520744 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 339) 1865 258.4 2.7e-68 >>NP_001135762 (OMIM: 607559) E3 ubiquitin-protein ligas (552 aa) initn: 3718 init1: 3718 opt: 3718 Z-score: 2663.7 bits: 502.7 E(85289): 1.2e-141 Smith-Waterman score: 3718; 100.0% identity (100.0% similar) in 552 aa overlap (1-552:1-552) 10 20 30 40 50 60 pF1KSD MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD SEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD QIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD SCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGIS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD DGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD GGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPA 490 500 510 520 530 540 550 pF1KSD LGPDSCSVGIDE :::::::::::: NP_001 LGPDSCSVGIDE 550 >>XP_005255277 (OMIM: 607559) PREDICTED: E3 ubiquitin-pr (552 aa) initn: 3718 init1: 3718 opt: 3718 Z-score: 2663.7 bits: 502.7 E(85289): 1.2e-141 Smith-Waterman score: 3718; 100.0% identity (100.0% similar) in 552 aa overlap (1-552:1-552) 10 20 30 40 50 60 pF1KSD MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD SEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD QIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD SCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGIS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD DGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD GGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPA 490 500 510 520 530 540 550 pF1KSD LGPDSCSVGIDE :::::::::::: XP_005 LGPDSCSVGIDE 550 >>XP_016878580 (OMIM: 607559) PREDICTED: E3 ubiquitin-pr (553 aa) initn: 2306 init1: 2306 opt: 3706 Z-score: 2655.2 bits: 501.1 E(85289): 3.7e-141 Smith-Waterman score: 3706; 99.8% identity (99.8% similar) in 553 aa overlap (1-552:1-553) 10 20 30 40 50 60 pF1KSD MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF 130 140 150 160 170 180 190 200 210 220 230 pF1KSD SEWKDDELNFDLDRGVFPVVIQAVVDEGD-VVEVTGHAHVLLAAFEKHMDGSFSVKPLKQ ::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::: XP_016 SEWKDDELNFDLDRGVFPVVIQAVVDEGDAVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KSD KQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLC 250 260 270 280 290 300 300 310 320 330 340 350 pF1KSD TSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFK 310 320 330 340 350 360 360 370 380 390 400 410 pF1KSD KSKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGI 370 380 390 400 410 420 420 430 440 450 460 470 pF1KSD SDGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KSD LGGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLP 490 500 510 520 530 540 540 550 pF1KSD ALGPDSCSVGIDE ::::::::::::: XP_016 ALGPDSCSVGIDE 550 >>XP_005255276 (OMIM: 607559) PREDICTED: E3 ubiquitin-pr (553 aa) initn: 2306 init1: 2306 opt: 3706 Z-score: 2655.2 bits: 501.1 E(85289): 3.7e-141 Smith-Waterman score: 3706; 99.8% identity (99.8% similar) in 553 aa overlap (1-552:1-553) 10 20 30 40 50 60 pF1KSD MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF 130 140 150 160 170 180 190 200 210 220 230 pF1KSD SEWKDDELNFDLDRGVFPVVIQAVVDEGD-VVEVTGHAHVLLAAFEKHMDGSFSVKPLKQ ::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::: XP_005 SEWKDDELNFDLDRGVFPVVIQAVVDEGDAVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KSD KQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLC 250 260 270 280 290 300 300 310 320 330 340 350 pF1KSD TSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFK 310 320 330 340 350 360 360 370 380 390 400 410 pF1KSD KSKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KSKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGI 370 380 390 400 410 420 420 430 440 450 460 470 pF1KSD SDGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KSD LGGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LGGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLP 490 500 510 520 530 540 540 550 pF1KSD ALGPDSCSVGIDE ::::::::::::: XP_005 ALGPDSCSVGIDE 550 >>NP_056061 (OMIM: 607559) E3 ubiquitin-protein ligase M (576 aa) initn: 3627 init1: 3627 opt: 3627 Z-score: 2598.7 bits: 490.7 E(85289): 5.2e-138 Smith-Waterman score: 3627; 100.0% identity (100.0% similar) in 539 aa overlap (1-539:1-539) 10 20 30 40 50 60 pF1KSD MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD SEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD QIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 QIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD SCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGIS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD DGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 DGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD GGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPG 490 500 510 520 530 540 550 pF1KSD LGPDSCSVGIDE NP_056 RPTSMETAHGLATTSPTWPPLGGPSPDPSAAELTPL 550 560 570 >>XP_005255274 (OMIM: 607559) PREDICTED: E3 ubiquitin-pr (577 aa) initn: 2215 init1: 2215 opt: 3615 Z-score: 2590.1 bits: 489.1 E(85289): 1.6e-137 Smith-Waterman score: 3615; 99.8% identity (99.8% similar) in 540 aa overlap (1-539:1-540) 10 20 30 40 50 60 pF1KSD MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF 130 140 150 160 170 180 190 200 210 220 230 pF1KSD SEWKDDELNFDLDRGVFPVVIQAVVDEGD-VVEVTGHAHVLLAAFEKHMDGSFSVKPLKQ ::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::: XP_005 SEWKDDELNFDLDRGVFPVVIQAVVDEGDAVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KSD KQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLC 250 260 270 280 290 300 300 310 320 330 340 350 pF1KSD TSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFK 310 320 330 340 350 360 360 370 380 390 400 410 pF1KSD KSKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KSKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGI 370 380 390 400 410 420 420 430 440 450 460 470 pF1KSD SDGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KSD LGGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LGGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLP 490 500 510 520 530 540 540 550 pF1KSD ALGPDSCSVGIDE XP_005 GRPTSMETAHGLATTSPTWPPLGGPSPDPSAAELTPL 550 560 570 >>XP_016878582 (OMIM: 607559) PREDICTED: E3 ubiquitin-pr (514 aa) initn: 3464 init1: 3464 opt: 3464 Z-score: 2483.3 bits: 469.2 E(85289): 1.4e-131 Smith-Waterman score: 3464; 100.0% identity (100.0% similar) in 514 aa overlap (39-552:1-514) 10 20 30 40 50 60 pF1KSD IAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDLNFLGSRPV :::::::::::::::::::::::::::::: XP_016 MGGEKFDTPHPEGYLFGENMDLNFLGSRPV 10 20 30 70 80 90 100 110 120 pF1KSD QFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSLEFTFDADA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSLEFTFDADA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KSD RVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDEL 100 110 120 130 140 150 190 200 210 220 230 240 pF1KSD NFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQKQIVDRVSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQKQIVDRVSY 160 170 180 190 200 210 250 260 270 280 290 300 pF1KSD LLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCTSCADTLRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCTSCADTLRY 220 230 240 250 260 270 310 320 330 340 350 360 pF1KSD QANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKKSKPHPASL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKKSKPHPASL 280 290 300 310 320 330 370 380 390 400 410 420 pF1KSD ASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQASC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQASC 340 350 360 370 380 390 430 440 450 460 470 480 pF1KSD PLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPLGGAELALR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPLGGAELALR 400 410 420 430 440 450 490 500 510 520 530 540 pF1KSD ESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPALGPDSCSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPALGPDSCSV 460 470 480 490 500 510 550 pF1KSD GIDE :::: XP_016 GIDE >>XP_011520743 (OMIM: 607559) PREDICTED: E3 ubiquitin-pr (539 aa) initn: 2215 init1: 2215 opt: 3361 Z-score: 2409.7 bits: 455.6 E(85289): 1.8e-127 Smith-Waterman score: 3361; 99.8% identity (99.8% similar) in 502 aa overlap (39-539:1-502) 10 20 30 40 50 60 pF1KSD IAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDLNFLGSRPV :::::::::::::::::::::::::::::: XP_011 MGGEKFDTPHPEGYLFGENMDLNFLGSRPV 10 20 30 70 80 90 100 110 120 pF1KSD QFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSLEFTFDADA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSLEFTFDADA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KSD RVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDEL 100 110 120 130 140 150 190 200 210 220 230 240 pF1KSD NFDLDRGVFPVVIQAVVDEGD-VVEVTGHAHVLLAAFEKHMDGSFSVKPLKQKQIVDRVS ::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::: XP_011 NFDLDRGVFPVVIQAVVDEGDAVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQKQIVDRVS 160 170 180 190 200 210 250 260 270 280 290 300 pF1KSD YLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCTSCADTLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCTSCADTLR 220 230 240 250 260 270 310 320 330 340 350 360 pF1KSD YQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKKSKPHPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKKSKPHPAS 280 290 300 310 320 330 370 380 390 400 410 420 pF1KSD LASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQAS 340 350 360 370 380 390 430 440 450 460 470 480 pF1KSD CPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPLGGAELAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPLGGAELAL 400 410 420 430 440 450 490 500 510 520 530 540 pF1KSD RESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPALGPDSCS :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPGRPTSMET 460 470 480 490 500 510 550 pF1KSD VGIDE XP_011 AHGLATTSPTWPPLGGPSPDPSAAELTPL 520 530 >>NP_001135763 (OMIM: 607559) E3 ubiquitin-protein ligas (530 aa) initn: 2401 init1: 2401 opt: 2462 Z-score: 1769.7 bits: 337.2 E(85289): 7.8e-92 Smith-Waterman score: 3509; 96.0% identity (96.0% similar) in 552 aa overlap (1-552:1-530) 10 20 30 40 50 60 pF1KSD MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD SEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD QIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD SCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKK ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHS----- 310 320 330 340 350 370 380 390 400 410 420 pF1KSD SKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGIS ::::::::::::::::::::::::::::::::::::::::::: NP_001 -----------------NSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGIS 360 370 380 390 430 440 450 460 470 480 pF1KSD DGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPL 400 410 420 430 440 450 490 500 510 520 530 540 pF1KSD GGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPA 460 470 480 490 500 510 550 pF1KSD LGPDSCSVGIDE :::::::::::: NP_001 LGPDSCSVGIDE 520 530 >>XP_005255278 (OMIM: 607559) PREDICTED: E3 ubiquitin-pr (530 aa) initn: 2401 init1: 2401 opt: 2462 Z-score: 1769.7 bits: 337.2 E(85289): 7.8e-92 Smith-Waterman score: 3509; 96.0% identity (96.0% similar) in 552 aa overlap (1-552:1-530) 10 20 30 40 50 60 pF1KSD MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD SEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD QIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD SCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKK ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHS----- 310 320 330 340 350 370 380 390 400 410 420 pF1KSD SKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGIS ::::::::::::::::::::::::::::::::::::::::::: XP_005 -----------------NSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGIS 360 370 380 390 430 440 450 460 470 480 pF1KSD DGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPL 400 410 420 430 440 450 490 500 510 520 530 540 pF1KSD GGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPA 460 470 480 490 500 510 550 pF1KSD LGPDSCSVGIDE :::::::::::: XP_005 LGPDSCSVGIDE 520 530 552 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 02:01:18 2016 done: Thu Nov 3 02:01:19 2016 Total Scan time: 9.930 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]