Result of FASTA (omim) for
pF1KSDA0573
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0573, 406 aa
1>>>pF1KSDA0573 406 - 406 aa - 406 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2525+/-0.000341; mu= 17.8918+/- 0.021
mean_var=68.3257+/-13.975, 0's: 0 Z-trim(114.1): 40 B-trim: 1372 in 1/56
Lambda= 0.155161
statistics sampled from 23673 (23713) to 23673 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.648), E-opt: 0.2 (0.278), width: 16
Scan time: 6.430
The best scores are: opt bits E(85289)
NP_055866 (OMIM: 609170) endoplasmic reticulum res ( 406) 2753 625.2 8.8e-179
NP_000909 (OMIM: 112240,176790) protein disulfide- ( 508) 329 82.6 2.3e-15
NP_005304 (OMIM: 602046) protein disulfide-isomera ( 505) 254 65.9 2.6e-10
NP_006840 (OMIM: 608012) protein disulfide-isomera ( 525) 238 62.3 3.2e-09
NP_001139021 (OMIM: 616412) thioredoxin domain-con ( 324) 229 60.1 8.8e-09
NP_110437 (OMIM: 616412) thioredoxin domain-contai ( 432) 229 60.2 1.1e-08
NP_001223 (OMIM: 114251,604772,611938) calsequestr ( 399) 211 56.2 1.7e-07
NP_001222 (OMIM: 114250,616231) calsequestrin-1 pr ( 396) 208 55.5 2.7e-07
NP_006801 (OMIM: 616942) protein disulfide-isomera ( 519) 195 52.7 2.5e-06
XP_011508610 (OMIM: 611099) PREDICTED: protein dis ( 402) 189 51.2 5.2e-06
NP_001269636 (OMIM: 611099) protein disulfide-isom ( 437) 189 51.3 5.6e-06
NP_005733 (OMIM: 611099) protein disulfide-isomera ( 440) 189 51.3 5.6e-06
NP_001269635 (OMIM: 611099) protein disulfide-isom ( 445) 189 51.3 5.7e-06
NP_001269634 (OMIM: 611099) protein disulfide-isom ( 488) 189 51.3 6.1e-06
NP_001269633 (OMIM: 611099) protein disulfide-isom ( 492) 189 51.3 6.1e-06
XP_006724289 (OMIM: 609063,616811) PREDICTED: thio ( 166) 174 47.7 2.6e-05
NP_036605 (OMIM: 609063,616811) thioredoxin, mitoc ( 166) 174 47.7 2.6e-05
XP_005261565 (OMIM: 609063,616811) PREDICTED: thio ( 197) 174 47.7 3e-05
XP_011524337 (OMIM: 616102) PREDICTED: protein dis ( 229) 169 46.6 7.3e-05
XP_011524336 (OMIM: 616102) PREDICTED: protein dis ( 231) 169 46.6 7.4e-05
NP_061895 (OMIM: 616102) protein disulfide-isomera ( 454) 170 47.0 0.00011
NP_110382 (OMIM: 610527) thioredoxin-related trans ( 280) 165 45.8 0.00016
NP_001258510 (OMIM: 607987) dnaJ homolog subfamily ( 747) 155 43.8 0.0017
NP_061854 (OMIM: 607987) dnaJ homolog subfamily C ( 793) 155 43.8 0.0018
NP_003320 (OMIM: 187700) thioredoxin isoform 1 [Ho ( 105) 142 40.4 0.0026
>>NP_055866 (OMIM: 609170) endoplasmic reticulum residen (406 aa)
initn: 2753 init1: 2753 opt: 2753 Z-score: 3330.7 bits: 625.2 E(85289): 8.8e-179
Smith-Waterman score: 2753; 100.0% identity (100.0% similar) in 406 aa overlap (1-406:1-406)
10 20 30 40 50 60
pF1KSD MHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENIDEILNNADVALVNFYADWCRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENIDEILNNADVALVNFYADWCRF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD SQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD REYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVFER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 REYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVFER
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD VANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPDMVYLGAMTNFDVTYNWIQDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPDMVYLGAMTNFDVTYNWIQDK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD CVPLVREITFENGEELTEEGLPFLILFHMKEDTESLEIFQNEVARQLISEKGTINFLHAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 CVPLVREITFENGEELTEEGLPFLILFHMKEDTESLEIFQNEVARQLISEKGTINFLHAD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD CDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFGDFKDVLIPGKLKQFVFDLHSGKLHREF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 CDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFGDFKDVLIPGKLKQFVFDLHSGKLHREF
310 320 330 340 350 360
370 380 390 400
pF1KSD HHGPDPTDTAPGEQAQDVASSPPESSFQKLAPSEYRYTLLRDRDEL
::::::::::::::::::::::::::::::::::::::::::::::
NP_055 HHGPDPTDTAPGEQAQDVASSPPESSFQKLAPSEYRYTLLRDRDEL
370 380 390 400
>>NP_000909 (OMIM: 112240,176790) protein disulfide-isom (508 aa)
initn: 190 init1: 122 opt: 329 Z-score: 396.8 bits: 82.6 E(85289): 2.3e-15
Smith-Waterman score: 340; 23.6% identity (54.9% similar) in 377 aa overlap (31-392:26-395)
10 20 30 40 50 60
pF1KSD MHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENIDEILNNADVALVNFYADWCRF
. : :. : : ::.::: ::
NP_000 MLRRALLCLAVAALVRADAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGH
10 20 30 40 50
70 80 90 100 110
pF1KSD SQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNG-MMM
. : : . .:. .: : ... .:.:: ..::.::.: . :::.:.::::
NP_000 CKALAPEYAKAAGKLKAE---GSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTAS
60 70 80 90 100 110
120 130 140 150 160 170
pF1KSD KREYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTL-DRSKRNIIGYFEQKDSDNYRVF
.:: . : . ........ . . : : .: . :. .::.:.. .::. . :
NP_000 PKEYTAGREADDIVNWLKKRTGPAATTLPDGAAAESLVESSEVAVIGFFKDVESDSAKQF
120 130 140 150 160 170
180 190 200 210 220 230
pF1KSD ERVANILHDDCAF-LSAFGDVSKPERYSGDNII-YKPPGHSAPDMVYLGAMTNFDVTYNW
..:. . :: : ... .:: . . . :... .: .. . . : .:. .. ..
NP_000 LQAAEAI-DDIPFGITSNSDVFSKYQLDKDGVVLFKKFDEGRNN--FEGEVTKENLL-DF
180 190 200 210 220
240 250 260 270 280 290
pF1KSD IQDKCVPLVREITFENGEELTEEGLPFLILFHMKEDTESLEIFQNEVARQLISEKGTINF
:. . .::: :.: ... .. . ::. . ... . . .. : :: : :
NP_000 IKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILF
230 240 250 260 270 280
300 310 320 330 340 350
pF1KSD LHADCDKFRHP--LLHIQKTPADCPVIAIDSFRH-MYVFGDFKDVLIPGKLKQFVFDLHS
. : :. . : . .::.. . .... : . .. : .. .: .
NP_000 IFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESEELTAERITEFCHRFLE
290 300 310 320 330 340
360 370 380 390 400
pF1KSD GKL--HREFHHGPDPTDTAP-----GEQAQDVASSPPESSFQKL-APSEYRYTLLRDRDE
::. : .. :. : : :.. .::: . .. : .. ::
NP_000 GKIKPHLMSQELPEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWD
350 360 370 380 390 400
pF1KSD L
NP_000 KLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKK
410 420 430 440 450 460
>>NP_005304 (OMIM: 602046) protein disulfide-isomerase A (505 aa)
initn: 173 init1: 103 opt: 254 Z-score: 306.1 bits: 65.9 E(85289): 2.6e-10
Smith-Waterman score: 317; 24.6% identity (58.7% similar) in 378 aa overlap (18-371:14-377)
10 20 30 40 50
pF1KSD MHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENIDEILNN---ADVALVNFYADW
::.. . ..... : .:.. ... : . ::.:.: :
NP_005 MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPW
10 20 30 40 50
60 70 80 90 100 110
pF1KSD CRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGM
: . : : .: :. .: : .:.::: ... ..: .: :::::.::.:
NP_005 CGHCKRLAPEYEAAATRLKGIVP------LAKVDCTANTNTCNKYGVSGYPTLKIFRDGE
60 70 80 90 100 110
120 130 140 150 160 170
pF1KSD MMKREYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTLDRSKR-NIIGYFEQKDSDNYR
: : :.. ........: . .: :. . .: .:.:.:... :. .
NP_005 EAG-AYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHS
120 130 140 150 160
180 190 200 210 220
pF1KSD VFERVANILHDDCAFLSAFGDV-SKPERY--SGDNIIYKPPGHSA-----PDMVYL-GAM
: ..:. :.:. : : .: : ..: .:..:: :.: . ..: :
NP_005 EFLKAASNLRDNYRF--AHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKM
170 180 190 200 210 220
230 240 250 260 270 280
pF1KSD TNFDVTYNWIQDKCVPLVREITFENGEELTEEGLPFLILFH---MKEDTESLEIFQNEV-
:. . ..::.. . ..: :....: . : .:: .. ....... . ..:.:
NP_005 TSGKIK-KFIQENIFGICPHMT-EDNKDLIQ-GKDLLIAYYDVDYEKNAKGSNYWRNRVM
230 240 250 260 270 280
290 300 310 320 330
pF1KSD --ARQLISEKGTINFLHADCDKFRHPL--LHIQKTPADCPVIAIDSFR-HMYVFGDFKDV
:..... .:: :. : : : . ...: .. ::.:: . . . .:. . .
NP_005 MVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQE--EF
290 300 310 320 330 340
340 350 360 370 380 390
pF1KSD LIPGK-LKQFVFDLHSGKLHREFHHGPDP-TDTAPGEQAQDVASSPPESSFQKLAPSEYR
:: :..:. : .:.:.: .. : : .. .:
NP_005 SRDGKALERFLQDYFDGNLKRYLKSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFY
350 360 370 380 390 400
400
pF1KSD YTLLRDRDEL
NP_005 APWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKL
410 420 430 440 450 460
>--
initn: 124 init1: 57 opt: 188 Z-score: 226.2 bits: 51.1 E(85289): 7.3e-06
Smith-Waterman score: 188; 29.8% identity (66.7% similar) in 114 aa overlap (37-146:384-492)
10 20 30 40 50 60
pF1KSD LSLPDLRCSLLLLVTWVFTPVTTEITSLDTENIDEILNNADV-ALVNFYADWCRFSQMLH
::.:::.:: . .:..::: :: . :.
NP_005 QDYFDGNLKRYLKSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLE
360 370 380 390 400 410
70 80 90 100 110 120
pF1KSD PIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLF-RNGMMMKREYR
: ..: .. .... :: .:.:..: . :. . :.. .::. . : . ..:.
NP_005 PKYKELGEKLSKD-PN---IVIAKMDATAN-DVPSPYEVRGFPTIYFSPANKKLNPKKYE
420 430 440 450 460
130 140 150 160 170 180
pF1KSD GQRSVKALADYIRQQKSDP--IQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVFERVA
: : .. . .:.... ..: :::
NP_005 GGRELSDFISYLQREATNPPVIQEEKPKKKKKAQEDL
470 480 490 500
>>NP_006840 (OMIM: 608012) protein disulfide-isomerase A (525 aa)
initn: 150 init1: 106 opt: 238 Z-score: 286.5 bits: 62.3 E(85289): 3.2e-09
Smith-Waterman score: 238; 27.6% identity (61.9% similar) in 181 aa overlap (26-204:39-211)
10 20 30 40 50
pF1KSD MHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENIDEILNNADVALVNFYA
: : :. ... : . . ::.:::
NP_006 LLLLLLRASCPWGQEQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREHPALLVEFYA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD DWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRN
:: : : : . .:. :. : :..:.:: . ..:... ...:::::.:::
NP_006 PWCGHCQALAPEYSKAAAVLAAE---SMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRN
70 80 90 100 110 120
120 130 140 150 160 170
pF1KSD GMMMK-REYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTLDRSKR-NIIGYFEQKDSD
: . .:: : :.....:...:.. . ....: : .: .. .::.:.. ...
NP_006 GNRTHPEEYTGPRDAEGIAEWLRRRVGPSAMRLEDEAAAQALIGGRDLVVIGFFQDLQDE
130 140 150 160 170 180
180 190 200 210 220 230
pF1KSD NYRVFERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPDMVYLGAMTNFDVT
. .: .: .: :. .:: ...:. .
NP_006 DVATFLALA---QD--ALDMTFGLTDRPRLFQQFGLTKDTVVLFKKFDEGRADFPVDEEL
190 200 210 220 230 240
240 250 260 270 280 290
pF1KSD YNWIQDKCVPLVREITFENGEELTEEGLPFLILFHMKEDTESLEIFQNEVARQLISEKGT
NP_006 GLDLGDLSRFLVTHSMRLVTEFNSQTSAKIFAARILNHLLLFVNQTLAAHRELLAGFGEA
250 260 270 280 290 300
>>NP_001139021 (OMIM: 616412) thioredoxin domain-contain (324 aa)
initn: 205 init1: 118 opt: 229 Z-score: 278.6 bits: 60.1 E(85289): 8.8e-09
Smith-Waterman score: 229; 33.3% identity (64.9% similar) in 114 aa overlap (31-144:216-324)
10 20 30 40 50 60
pF1KSD MHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENIDEILNNADVALVNFYADWCRF
. .: .:.:. . .. .....::: ::
NP_001 LQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEG-ITFIKFYAPWCGH
190 200 210 220 230 240
70 80 90 100 110 120
pF1KSD SQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMK
. : : .:: : :.:::. : .:.::: . .: ..: . :::: :::.: ..
NP_001 CKTLAPTWEELS---KKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVS
250 260 270 280 290 300
130 140 150 160 170 180
pF1KSD REYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVFER
:. : :.. .: .. .: .: .
NP_001 -EHSGGRDLDSLHRFVLSQAKDEL
310 320
>>NP_110437 (OMIM: 616412) thioredoxin domain-containing (432 aa)
initn: 239 init1: 118 opt: 229 Z-score: 276.8 bits: 60.2 E(85289): 1.1e-08
Smith-Waterman score: 229; 33.3% identity (64.9% similar) in 114 aa overlap (31-144:324-432)
10 20 30 40 50 60
pF1KSD MHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENIDEILNNADVALVNFYADWCRF
. .: .:.:. . .. .....::: ::
NP_110 LQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEG-ITFIKFYAPWCGH
300 310 320 330 340 350
70 80 90 100 110 120
pF1KSD SQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMK
. : : .:: : :.:::. : .:.::: . .: ..: . :::: :::.: ..
NP_110 CKTLAPTWEELS---KKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVS
360 370 380 390 400
130 140 150 160 170 180
pF1KSD REYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVFER
:. : :.. .: .. .: .: .
NP_110 -EHSGGRDLDSLHRFVLSQAKDEL
410 420 430
>--
initn: 235 init1: 101 opt: 196 Z-score: 236.9 bits: 52.8 E(85289): 1.9e-06
Smith-Waterman score: 196; 33.3% identity (62.5% similar) in 96 aa overlap (50-144:81-173)
20 30 40 50 60 70
pF1KSD VTWVFTPVTTEITSLDTENIDEILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEF
.: :.: :: : :.: ... .: : .
NP_110 AADGEDGQDPHSKHLYTADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGD--KYNS
60 70 80 90 100
80 90 100 110 120 130
pF1KSD PNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQ
.. .: :.::: :::. . . :::::::. :. . :.: :. ..: ... :
NP_110 MEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVK-YQGPRDFQTLENWMLQT
110 120 130 140 150 160
140 150 160 170 180 190
pF1KSD -KSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDV
. .:.
NP_110 LNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTW
170 180 190 200 210 220
>--
initn: 149 init1: 88 opt: 176 Z-score: 212.7 bits: 48.4 E(85289): 4.1e-05
Smith-Waterman score: 176; 28.9% identity (64.4% similar) in 90 aa overlap (50-139:209-293)
20 30 40 50 60 70
pF1KSD VTWVFTPVTTEITSLDTENIDEILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEF
...:.: :: . : : .:. . .
NP_110 VEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQ----LALGL
180 190 200 210 220 230
80 90 100 110 120 130
pF1KSD PNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQ
. . : ...::: :: .. . .. :::: ::.: . .:.:.:....: .:...:
NP_110 EHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVD-QYKGKRDLESLREYVESQ
240 250 260 270 280 290
140 150 160 170 180 190
pF1KSD KSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDVS
NP_110 LQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHC
300 310 320 330 340 350
>>NP_001223 (OMIM: 114251,604772,611938) calsequestrin-2 (399 aa)
initn: 70 init1: 70 opt: 211 Z-score: 255.5 bits: 56.2 E(85289): 1.7e-07
Smith-Waterman score: 235; 21.3% identity (57.7% similar) in 366 aa overlap (31-377:34-391)
10 20 30 40 50 60
pF1KSD MHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENIDEILNNADVALVNFYADWCRF
..::. .:. ..:.. :. : .: .
NP_001 THLFIVGIYFLSSCRAEEGLNFPTYDGKDRVVSLSEKNFKQVLKKYDL-LCLYYHEPVSS
10 20 30 40 50 60
70 80 90 100 110
pF1KSD SQMLHPIFEEASDVIKEEFPN--ENQVV-FARVDCDQHSDIAQRYRISKYPTLKLFRNGM
... . :. .... : . :.... :. :: ... .:.. ... .: ....
NP_001 DKVTQKQFQ-LKEIVLELVAQVLEHKAIGFVMVDAKKEAKLAKKLGFDEEGSLYILKGDR
70 80 90 100 110 120
120 130 140 150 160 170
pF1KSD MMKREYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTLDRSKRNI--IGYFEQKDSDNY
. :. :. .. .:.... . ::.. : . :. ...: . : ::.:...::. :
NP_001 TI--EFDGEFAADVLVEFLLDLIEDPVEIISSKLEVQAFERIEDYIKLIGFFKSEDSEYY
130 140 150 160 170
180 190 200 210 220 230
pF1KSD RVFERVANILHDDCAFLSAFGD-VSKPERYSGDNIIYKPPGHSAPDMVYLGAMTNFDVTY
..::..:. .. :...: :.: . ... . : . : . .:. ...
NP_001 KAFEEAAEHFQPYIKFFATFDKGVAKKLSLKMNEVDFYEPFMDEPIAIPNKPYTEEELV-
180 190 200 210 220 230
240 250 260 270 280 290
pF1KSD NWIQDKCVPLVREITFENGEELTEEGLP--FLILFHMKEDTESLEIFQ--NEVARQLISE
...... : .:.. :. : :. : .. : : : .. :... ..:::. ..
NP_001 EFVKEHQRPTLRRLRPEEMFETWEDDLNGIHIVAFAEKSDPDGYEFLEILKQVARD-NTD
240 250 260 270 280 290
300 310 320 330 340
pF1KSD KGTINFLHADCDKFRHPLL--HIQKT-PADC--PVIAI----DSFRHMYVFGDFKDVLIP
. ...: : : : ::: . .:: : : :.. :. . . : :.
NP_001 NPDLSILWIDPDDF--PLLVAYWEKTFKIDLFRPQIGVVNVTDADSVWMEIPDDDDLPTA
300 310 320 330 340 350
350 360 370 380 390 400
pF1KSD GKLKQFVFDLHSGKLHREFHHGPDPTDTAPGEQAQDVASSPPESSFQKLAPSEYRYTLLR
.:.... :. :::.. : : : :. .:
NP_001 EELEDWIEDVLSGKINTEDDDEDDDDDDNSDEEDNDDSDDDDDE
360 370 380 390
pF1KSD DRDEL
>>NP_001222 (OMIM: 114250,616231) calsequestrin-1 precur (396 aa)
initn: 115 init1: 87 opt: 208 Z-score: 252.0 bits: 55.5 E(85289): 2.7e-07
Smith-Waterman score: 216; 20.8% identity (56.0% similar) in 384 aa overlap (8-359:11-388)
10 20 30 40 50
pF1KSD MHPAVFLSLPDLRCSLLLLVTWVFTPVT--TEITSLDT---ENIDEILNNADVALVN
..: :: .::::.. . :: . .:: ...:...: :
NP_001 MSATDRMGPRAVPGLRLALLLLLV-LGTPKSGVQGQEGLDFPEYDGVDRVINVNAKNYKN
10 20 30 40 50
60 70 80 90 100
pF1KSD FYADWCRFSQMLH--PIFEEAS-------DVIKE---EFPNENQVVFARVDCDQHSDIAQ
. . .. . : : ..:: ..: : . ... : :. :: .. . .:.
NP_001 VFKKYEVLALLYHEPPEDDKASQRQFEMEELILELAAQVLEDKGVGFGLVDSEKDAAVAK
60 70 80 90 100 110
110 120 130 140 150 160
pF1KSD RYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTLDRSK
. ... .. .:.. .. :: :. :. ...... . ::.. :. :. ... .
NP_001 KLGLTEVDSMYVFKGDEVI--EYDGEFSADTIVEFLLDVLEDPVELIEGERELQAFENIE
120 130 140 150 160 170
170 180 190 200 210
pF1KSD RNI--IGYFEQKDSDNYRVFERVANILHDDCAFLSAFGD-VSKPERYSGDNIIYKPPGHS
.: ::::..:::..:..:: .:. .: :...: . :.: . ..: .
NP_001 DEIKLIGYFKSKDSEHYKAFEDAAEEFHPYIPFFATFDSKVAKKLTLKLNEIDFYEAFME
180 190 200 210 220 230
220 230 240 250 260 270
pF1KSD APDMVYLGAMTNFDVTYNWIQDKCVPLVREITFENGEELTEEGLP--FLILFHMKEDTES
: . .. ... :..... .:.. :. : :. . .. : . : ..
NP_001 EPVTIPDKPNSEEEIV-NFVEEHRRSTLRKLKPESMYETWEDDMDGIHIVAFAEEADPDG
240 250 260 270 280 290
280 290 300 310 320
pF1KSD LEIFQN-EVARQLISEKGTINFLHADCDKFRHPLL--HIQKT---PADCPVIAI----DS
.:.... ... : .:. .... : : : ::: . .:: . : :.. :.
NP_001 FEFLETLKAVAQDNTENPDLSIIWIDPDDF--PLLVPYWEKTFDIDLSAPQIGVVNVTDA
300 310 320 330 340 350
330 340 350 360 370 380
pF1KSD FRHMYVFGDFKDVLIPGKLKQFVFDLHSGKLHREFHHGPDPTDTAPGEQAQDVASSPPES
. . : .:. .:.... :. :... :
NP_001 DSVWMEMDDEEDLPSAEELEDWLEDVLEGEINTEDDDDDDDD
360 370 380 390
390 400
pF1KSD SFQKLAPSEYRYTLLRDRDEL
>>NP_006801 (OMIM: 616942) protein disulfide-isomerase A (519 aa)
initn: 256 init1: 102 opt: 195 Z-score: 234.5 bits: 52.7 E(85289): 2.5e-06
Smith-Waterman score: 195; 29.6% identity (64.0% similar) in 125 aa overlap (25-146:269-389)
10 20 30 40 50
pF1KSD MHPAVFLSLPDLRCSLLLLVTWVFTPVTTE---ITSLDTENIDEILNNADVALV
:: . : . : :..:..... . .::
NP_006 LFQYDNYGSTAEDIVEWLKNPQPPQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVLV
240 250 260 270 280 290
60 70 80 90 100 110
pF1KSD NFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLK
:.: :: . ..: ::.:..... : ... :.: :: .. .:.:..::..::::
NP_006 MFHAPWCGHCKKMKPEFEKAAEALHGE--ADSSGVLAAVDATVNKALAERFHISEFPTLK
300 310 320 330 340 350
120 130 140 150 160 170
pF1KSD LFRNGMMMKREYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKD
:.:: : :. : . ..... .. : :
NP_006 YFKNG--EKYAVPVLRTKKKFLEWMQNPEAPPPPEPTWEEQQTSVLHLVGDNFRETLKKK
360 370 380 390 400 410
180 190 200 210 220 230
pF1KSD SDNYRVFERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPDMVYLGAMTNFD
NP_006 KHTLVMFYAPWCPHCKKVIPHFTATADAFKDDRKIACAAVDCVKDKNQDLCQQEAVKGYP
420 430 440 450 460 470
>--
initn: 117 init1: 56 opt: 176 Z-score: 211.5 bits: 48.4 E(85289): 4.8e-05
Smith-Waterman score: 176; 28.8% identity (62.2% similar) in 111 aa overlap (29-137:397-502)
10 20 30 40 50
pF1KSD MHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENIDEILNNADVALVNFYADWC
: . : .:. : :.. .:: ::: ::
NP_006 PVLRTKKKFLEWMQNPEAPPPPEPTWEEQQTSVLHLVGDNFRETLKKKKHTLVMFYAPWC
370 380 390 400 410 420
60 70 80 90 100 110
pF1KSD RFSQMLHPIFEEASDVIKEEFPNENQVVFARVDC--DQHSDIAQRYRISKYPTLKLFRNG
. . : : ..:. : .. ... : ::: :...:. :. .. :::.. .. :
NP_006 PHCKKVIPHFTATADA----FKDDRKIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYG
430 440 450 460 470 480
120 130 140 150 160 170
pF1KSD MMMKREYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYR
. .. : ..:. ....:::
NP_006 KFAEK-YDSDRTELGFTNYIRALREGDHERLGKKKEEL
490 500 510
>>XP_011508610 (OMIM: 611099) PREDICTED: protein disulfi (402 aa)
initn: 203 init1: 92 opt: 189 Z-score: 228.9 bits: 51.2 E(85289): 5.2e-06
Smith-Waterman score: 196; 26.9% identity (63.8% similar) in 130 aa overlap (6-134:3-125)
10 20 30 40 50
pF1KSD MHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENID-EILNNADVALVNFYADWCR
.: : . :...: :. ... . .. : :.. :.... .. ::.::: ::
XP_011 MALLVLGLVSCTFFLAVNGLYSS-SDDVIELTPSNFNREVIQSDSLWLVEFYAPWCG
10 20 30 40 50
60 70 80 90 100 110
pF1KSD FSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMM
: : : ...:. ..:. : . :: :.: ... .: .. .::.:.: ..
XP_011 HCQRLTPEWKKAATALKDV------VKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KSD KREYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVFE
..:.: :. .:..:
XP_011 PEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSF
120 130 140 150 160 170
>--
initn: 231 init1: 92 opt: 189 Z-score: 228.9 bits: 51.2 E(85289): 5.2e-06
Smith-Waterman score: 189; 30.1% identity (61.7% similar) in 133 aa overlap (30-161:161-289)
10 20 30 40 50
pF1KSD MHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENIDE-ILNNADVALVNFYADWC
.. : ...:. .:.. :: .:.::: ::
XP_011 LRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWC
140 150 160 170 180 190
60 70 80 90 100 110
pF1KSD RFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMM
. :.: . :.. .::. ....: .: :: .. .:.:: : .::.:.:..:
XP_011 GHCKNLEPEWAAAASEVKEQ--TKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGES
200 210 220 230 240
120 130 140 150 160 170
pF1KSD MKREYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVF
.: : :. . ... . :: .: :: . : .::
XP_011 -PVDYDGGRTRSDIVSRALDLFSDNAPPP-ELLEIINEDIAKRTCEEHQLCVVAVLPHIL
250 260 270 280 290 300
180 190 200 210 220 230
pF1KSD ERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPDMVYLGAMTNFDVTYNWIQ
XP_011 DTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINARK
310 320 330 340 350 360
406 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 02:07:46 2016 done: Thu Nov 3 02:07:47 2016
Total Scan time: 6.430 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]