FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0578, 1496 aa 1>>>pF1KSDA0578 1496 - 1496 aa - 1496 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.8470+/-0.000534; mu= 15.0251+/- 0.033 mean_var=115.4273+/-21.637, 0's: 0 Z-trim(110.6): 256 B-trim: 0 in 0/52 Lambda= 0.119377 statistics sampled from 18692 (19006) to 18692 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.558), E-opt: 0.2 (0.223), width: 16 Scan time: 12.030 The best scores are: opt bits E(85289) NP_001317011 (OMIM: 600565,614325,614332) neurexin (1496) 10032 1740.6 0 NP_001317006 (OMIM: 600565,614325,614332) neurexin (1499) 10016 1737.9 0 NP_001317015 (OMIM: 600565,614325,614332) neurexin (1504) 10006 1736.2 0 NP_001317007 (OMIM: 600565,614325,614332) neurexin (1507) 9990 1733.4 0 XP_011531477 (OMIM: 600565,614325,614332) PREDICTE (1495) 9973 1730.5 0 NP_001317022 (OMIM: 600565,614325,614332) neurexin (1506) 9972 1730.3 0 NP_001317023 (OMIM: 600565,614325,614332) neurexin (1500) 9963 1728.8 0 XP_016860816 (OMIM: 600565,614325,614332) PREDICTE (1466) 8343 1449.7 0 NP_004792 (OMIM: 600565,614325,614332) neurexin-1 (1477) 8317 1445.3 0 XP_016860815 (OMIM: 600565,614325,614332) PREDICTE (1471) 8256 1434.8 0 XP_016860807 (OMIM: 600565,614325,614332) PREDICTE (1499) 7936 1379.7 0 XP_005264699 (OMIM: 600565,614325,614332) PREDICTE (1511) 7451 1296.1 0 XP_011531469 (OMIM: 600565,614325,614332) PREDICTE (1514) 7435 1293.4 0 NP_001129131 (OMIM: 600565,614325,614332) neurexin (1547) 7435 1293.4 0 XP_016860800 (OMIM: 600565,614325,614332) PREDICTE (1508) 7235 1258.9 0 XP_016860797 (OMIM: 600565,614325,614332) PREDICTE (1516) 7209 1254.5 0 XP_016860809 (OMIM: 600565,614325,614332) PREDICTE (1495) 7195 1252.0 0 XP_016860804 (OMIM: 600565,614325,614332) PREDICTE (1502) 7182 1249.8 0 NP_001317014 (OMIM: 600565,614325,614332) neurexin (1498) 7179 1249.3 0 XP_016860805 (OMIM: 600565,614325,614332) PREDICTE (1502) 7174 1248.4 0 XP_011531474 (OMIM: 600565,614325,614332) PREDICTE (1505) 7166 1247.0 0 XP_011535674 (OMIM: 600567) PREDICTED: neurexin 3 (1476) 6796 1183.3 0 XP_011535673 (OMIM: 600567) PREDICTED: neurexin 3 (1479) 6783 1181.1 0 XP_005274459 (OMIM: 600566) PREDICTED: neurexin-2- (1503) 6771 1179.0 0 XP_016877292 (OMIM: 600567) PREDICTED: neurexin 3 (1468) 6721 1170.4 0 XP_016877294 (OMIM: 600567) PREDICTED: neurexin 3 (1464) 6681 1163.5 0 XP_011531482 (OMIM: 600565,614325,614332) PREDICTE (1450) 6622 1153.3 0 XP_005274458 (OMIM: 600566) PREDICTED: neurexin-2- (1511) 6412 1117.2 0 XP_016860803 (OMIM: 600565,614325,614332) PREDICTE (1503) 6396 1114.4 0 XP_016860799 (OMIM: 600565,614325,614332) PREDICTE (1513) 6396 1114.4 0 XP_016877279 (OMIM: 600567) PREDICTED: neurexin 3 (1687) 6306 1099.0 0 XP_011535665 (OMIM: 600567) PREDICTED: neurexin 3 (1687) 6306 1099.0 0 XP_011535667 (OMIM: 600567) PREDICTED: neurexin 3 (1687) 6306 1099.0 0 XP_011535666 (OMIM: 600567) PREDICTED: neurexin 3 (1687) 6306 1099.0 0 XP_016877280 (OMIM: 600567) PREDICTED: neurexin 3 (1687) 6306 1099.0 0 XP_011535670 (OMIM: 600567) PREDICTED: neurexin 3 (1586) 6298 1097.6 0 XP_011535671 (OMIM: 600567) PREDICTED: neurexin 3 (1583) 6295 1097.1 0 XP_005268275 (OMIM: 600567) PREDICTED: neurexin 3 (1684) 6295 1097.1 0 XP_011535668 (OMIM: 600567) PREDICTED: neurexin 3 (1679) 6231 1086.0 0 XP_011535672 (OMIM: 600567) PREDICTED: neurexin 3 (1575) 6220 1084.1 0 XP_016877284 (OMIM: 600567) PREDICTED: neurexin 3 (1675) 6191 1079.2 0 XP_016877283 (OMIM: 600567) PREDICTED: neurexin 3 (1675) 6191 1079.2 0 NP_001317124 (OMIM: 600567) neurexin 3 isoform 5 [ (1571) 6180 1077.2 0 XP_016877281 (OMIM: 600567) PREDICTED: neurexin 3 (1683) 6165 1074.7 0 XP_006720385 (OMIM: 600567) PREDICTED: neurexin 3 (1683) 6165 1074.7 0 XP_016877286 (OMIM: 600567) PREDICTED: neurexin 3 (1667) 5990 1044.5 0 XP_011543677 (OMIM: 600566) PREDICTED: neurexin-2- (1700) 5898 1028.7 0 XP_005274457 (OMIM: 600566) PREDICTED: neurexin-2- (1705) 5886 1026.6 0 XP_016874060 (OMIM: 600566) PREDICTED: neurexin-2- (1518) 5825 1016.1 0 XP_016874059 (OMIM: 600566) PREDICTED: neurexin-2- (1521) 5809 1013.3 0 >>NP_001317011 (OMIM: 600565,614325,614332) neurexin-1 i (1496 aa) initn: 10032 init1: 10032 opt: 10032 Z-score: 9338.7 bits: 1740.6 E(85289): 0 Smith-Waterman score: 10032; 100.0% identity (100.0% similar) in 1496 aa overlap (1-1496:1-1496) 10 20 30 40 50 60 pF1KSD MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD AVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD KFNDNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KFNDNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD SFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD HLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILD 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD LDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD KPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD IQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRIN 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD CNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD TGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVT 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD FKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD GNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYI 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD GGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQ 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD EDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTR 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD ADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIIN 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD DGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLD 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KSD KGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVG 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KSD EVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAEC 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KSD PSDDEDIDPCEPSSANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSDDEDIDPCEPSSANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYA 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 pF1KSD MYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1450 1460 1470 1480 1490 >>NP_001317006 (OMIM: 600565,614325,614332) neurexin-1 i (1499 aa) initn: 10018 init1: 9383 opt: 10016 Z-score: 9323.8 bits: 1737.9 E(85289): 0 Smith-Waterman score: 10016; 99.8% identity (99.8% similar) in 1499 aa overlap (1-1496:1-1499) 10 20 30 40 50 60 pF1KSD MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD AVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD KFNDNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KFNDNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD SFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD HLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILD 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD LDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD KPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD IQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRIN 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD CNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD TGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVT 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD FKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD GNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYI 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD GGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQ 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD EDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTR 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD ADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIIN 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD DGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLD 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KSD KGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVG 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KSD EVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAEC 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 pF1KSD PSDDEDIDPCEPSS---ANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILIL :::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: NP_001 PSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILIL 1390 1400 1410 1420 1430 1440 1440 1450 1460 1470 1480 1490 pF1KSD LYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1450 1460 1470 1480 1490 >>NP_001317015 (OMIM: 600565,614325,614332) neurexin-1 i (1504 aa) initn: 10018 init1: 7451 opt: 10006 Z-score: 9314.5 bits: 1736.2 E(85289): 0 Smith-Waterman score: 10006; 99.5% identity (99.5% similar) in 1504 aa overlap (1-1496:1-1504) 10 20 30 40 50 60 pF1KSD MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD AVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG 310 320 330 340 350 360 370 380 390 400 410 pF1KSD KFNDNAWHDVKVTRNLRQ--------VTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSP :::::::::::::::::: :::::::::::::::::::::::::::::::::: NP_001 KFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSP 370 380 390 400 410 420 420 430 440 450 460 470 pF1KSD STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLD 430 440 450 460 470 480 480 490 500 510 520 530 pF1KSD PITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDF 490 500 510 520 530 540 540 550 560 570 580 590 pF1KSD FAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTA 550 560 570 580 590 600 600 610 620 630 640 650 pF1KSD PGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMA 610 620 630 640 650 660 660 670 680 690 700 710 pF1KSD EVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLS 670 680 690 700 710 720 720 730 740 750 760 770 pF1KSD YDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTV 730 740 750 760 770 780 780 790 800 810 820 830 pF1KSD NLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHT 790 800 810 820 830 840 840 850 860 870 880 890 pF1KSD RLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFR 850 860 870 880 890 900 900 910 920 930 940 950 pF1KSD NIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKG 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KSD YLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNL 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KSD DLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KSD EGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWP 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KSD PNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAI 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KSD EESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGR 1210 1220 1230 1240 1250 1260 1260 1270 1280 1290 1300 1310 pF1KSD VVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAI 1270 1280 1290 1300 1310 1320 1320 1330 1340 1350 1360 1370 pF1KSD VGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDD 1330 1340 1350 1360 1370 1380 1380 1390 1400 1410 1420 1430 pF1KSD ILVASAECPSDDEDIDPCEPSSANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILVASAECPSDDEDIDPCEPSSANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAAL 1390 1400 1410 1420 1430 1440 1440 1450 1460 1470 1480 1490 pF1KSD CILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDK 1450 1460 1470 1480 1490 1500 pF1KSD EYYV :::: NP_001 EYYV >>NP_001317007 (OMIM: 600565,614325,614332) neurexin-1 i (1507 aa) initn: 10004 init1: 6802 opt: 9990 Z-score: 9299.5 bits: 1733.4 E(85289): 0 Smith-Waterman score: 9990; 99.3% identity (99.3% similar) in 1507 aa overlap (1-1496:1-1507) 10 20 30 40 50 60 pF1KSD MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD AVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG 310 320 330 340 350 360 370 380 390 400 410 pF1KSD KFNDNAWHDVKVTRNLRQ--------VTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSP :::::::::::::::::: :::::::::::::::::::::::::::::::::: NP_001 KFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSP 370 380 390 400 410 420 420 430 440 450 460 470 pF1KSD STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLD 430 440 450 460 470 480 480 490 500 510 520 530 pF1KSD PITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDF 490 500 510 520 530 540 540 550 560 570 580 590 pF1KSD FAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTA 550 560 570 580 590 600 600 610 620 630 640 650 pF1KSD PGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMA 610 620 630 640 650 660 660 670 680 690 700 710 pF1KSD EVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLS 670 680 690 700 710 720 720 730 740 750 760 770 pF1KSD YDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTV 730 740 750 760 770 780 780 790 800 810 820 830 pF1KSD NLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHT 790 800 810 820 830 840 840 850 860 870 880 890 pF1KSD RLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFR 850 860 870 880 890 900 900 910 920 930 940 950 pF1KSD NIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKG 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KSD YLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNL 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KSD DLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KSD EGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWP 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KSD PNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAI 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KSD EESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGR 1210 1220 1230 1240 1250 1260 1260 1270 1280 1290 1300 1310 pF1KSD VVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAI 1270 1280 1290 1300 1310 1320 1320 1330 1340 1350 1360 1370 pF1KSD VGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDD 1330 1340 1350 1360 1370 1380 1380 1390 1400 1410 1420 pF1KSD ILVASAECPSDDEDIDPCEPSS---ANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAA :::::::::::::::::::::: ::::::::::::::::::::::::::::::::::: NP_001 ILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAA 1390 1400 1410 1420 1430 1440 1430 1440 1450 1460 1470 1480 pF1KSD AALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKN 1450 1460 1470 1480 1490 1500 1490 pF1KSD KDKEYYV ::::::: NP_001 KDKEYYV >>XP_011531477 (OMIM: 600565,614325,614332) PREDICTED: n (1495 aa) initn: 8095 init1: 7460 opt: 9973 Z-score: 9283.8 bits: 1730.5 E(85289): 0 Smith-Waterman score: 9973; 99.5% identity (99.5% similar) in 1499 aa overlap (1-1496:1-1495) 10 20 30 40 50 60 pF1KSD MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD AVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP ::::::::::::::::::::::::::::::::::: ::::::::::::::::::::: XP_011 AVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGK----EEYIATFKGSEYFCYDLSQNP 250 260 270 280 290 310 320 330 340 350 360 pF1KSD IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG 300 310 320 330 340 350 370 380 390 400 410 420 pF1KSD KFNDNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KFNDNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGS 360 370 380 390 400 410 430 440 450 460 470 480 pF1KSD PVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPE 420 430 440 450 460 470 490 500 510 520 530 540 pF1KSD SFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDG 480 490 500 510 520 530 550 560 570 580 590 600 pF1KSD HLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILD 540 550 560 570 580 590 610 620 630 640 650 660 pF1KSD LDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGV 600 610 620 630 640 650 670 680 690 700 710 720 pF1KSD KPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMK 660 670 680 690 700 710 730 740 750 760 770 780 pF1KSD IQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRIN 720 730 740 750 760 770 790 800 810 820 830 840 pF1KSD CNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIE 780 790 800 810 820 830 850 860 870 880 890 900 pF1KSD TGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVT 840 850 860 870 880 890 910 920 930 940 950 960 pF1KSD FKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDL 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KSD GNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYI 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KSD GGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQ 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KSD EDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTR 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KSD ADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIIN 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 1250 1260 pF1KSD DGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLD 1200 1210 1220 1230 1240 1250 1270 1280 1290 1300 1310 1320 pF1KSD KGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVG 1260 1270 1280 1290 1300 1310 1330 1340 1350 1360 1370 1380 pF1KSD EVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAEC 1320 1330 1340 1350 1360 1370 1390 1400 1410 1420 1430 pF1KSD PSDDEDIDPCEPSS---ANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILIL :::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: XP_011 PSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILIL 1380 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 pF1KSD LYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1440 1450 1460 1470 1480 1490 >>NP_001317022 (OMIM: 600565,614325,614332) neurexin-1 i (1506 aa) initn: 9225 init1: 6802 opt: 9972 Z-score: 9282.8 bits: 1730.3 E(85289): 0 Smith-Waterman score: 9972; 99.2% identity (99.2% similar) in 1507 aa overlap (1-1496:1-1506) 10 20 30 40 50 60 pF1KSD MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD AVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP ::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::: NP_001 AVCDCSRTGFRGKDCSQ-DNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP 250 260 270 280 290 310 320 330 340 350 360 pF1KSD IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG 300 310 320 330 340 350 370 380 390 400 410 pF1KSD KFNDNAWHDVKVTRNLRQ--------VTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSP :::::::::::::::::: :::::::::::::::::::::::::::::::::: NP_001 KFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSP 360 370 380 390 400 410 420 430 440 450 460 470 pF1KSD STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLD 420 430 440 450 460 470 480 490 500 510 520 530 pF1KSD PITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDF 480 490 500 510 520 530 540 550 560 570 580 590 pF1KSD FAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTA 540 550 560 570 580 590 600 610 620 630 640 650 pF1KSD PGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMA 600 610 620 630 640 650 660 670 680 690 700 710 pF1KSD EVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLS 660 670 680 690 700 710 720 730 740 750 760 770 pF1KSD YDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTV 720 730 740 750 760 770 780 790 800 810 820 830 pF1KSD NLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHT 780 790 800 810 820 830 840 850 860 870 880 890 pF1KSD RLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFR 840 850 860 870 880 890 900 910 920 930 940 950 pF1KSD NIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKG 900 910 920 930 940 950 960 970 980 990 1000 1010 pF1KSD YLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNL 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 pF1KSD DLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 pF1KSD EGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWP 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 pF1KSD PNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAI 1140 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 pF1KSD EESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGR 1200 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 pF1KSD VVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAI 1260 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 pF1KSD VGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDD 1320 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 pF1KSD ILVASAECPSDDEDIDPCEPSS---ANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAA :::::::::::::::::::::: ::::::::::::::::::::::::::::::::::: NP_001 ILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAA 1380 1390 1400 1410 1420 1430 1430 1440 1450 1460 1470 1480 pF1KSD AALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKN 1440 1450 1460 1470 1480 1490 1490 pF1KSD KDKEYYV ::::::: NP_001 KDKEYYV 1500 >>NP_001317023 (OMIM: 600565,614325,614332) neurexin-1 i (1500 aa) initn: 9351 init1: 7451 opt: 9963 Z-score: 9274.4 bits: 1728.8 E(85289): 0 Smith-Waterman score: 9963; 99.2% identity (99.2% similar) in 1504 aa overlap (1-1496:1-1500) 10 20 30 40 50 60 pF1KSD MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD AVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP ::::::::::::::::::::::::::::::::::: ::::::::::::::::::::: NP_001 AVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGK----EEYIATFKGSEYFCYDLSQNP 250 260 270 280 290 310 320 330 340 350 360 pF1KSD IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG 300 310 320 330 340 350 370 380 390 400 410 pF1KSD KFNDNAWHDVKVTRNLRQ--------VTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSP :::::::::::::::::: :::::::::::::::::::::::::::::::::: NP_001 KFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSP 360 370 380 390 400 410 420 430 440 450 460 470 pF1KSD STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLD 420 430 440 450 460 470 480 490 500 510 520 530 pF1KSD PITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDF 480 490 500 510 520 530 540 550 560 570 580 590 pF1KSD FAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTA 540 550 560 570 580 590 600 610 620 630 640 650 pF1KSD PGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMA 600 610 620 630 640 650 660 670 680 690 700 710 pF1KSD EVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLS 660 670 680 690 700 710 720 730 740 750 760 770 pF1KSD YDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTV 720 730 740 750 760 770 780 790 800 810 820 830 pF1KSD NLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHT 780 790 800 810 820 830 840 850 860 870 880 890 pF1KSD RLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFR 840 850 860 870 880 890 900 910 920 930 940 950 pF1KSD NIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKG 900 910 920 930 940 950 960 970 980 990 1000 1010 pF1KSD YLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNL 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 pF1KSD DLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 pF1KSD EGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWP 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 pF1KSD PNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAI 1140 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 pF1KSD EESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGR 1200 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 pF1KSD VVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAI 1260 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 pF1KSD VGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDD 1320 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 pF1KSD ILVASAECPSDDEDIDPCEPSSANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILVASAECPSDDEDIDPCEPSSANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAAL 1380 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 pF1KSD CILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDK 1440 1450 1460 1470 1480 1490 pF1KSD EYYV :::: NP_001 EYYV 1500 >>XP_016860816 (OMIM: 600565,614325,614332) PREDICTED: n (1466 aa) initn: 8343 init1: 8343 opt: 8343 Z-score: 7766.7 bits: 1449.7 E(85289): 0 Smith-Waterman score: 9758; 98.0% identity (98.0% similar) in 1496 aa overlap (1-1496:1-1466) 10 20 30 40 50 60 pF1KSD MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD AVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD KFNDNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KFNDNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD SFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD HLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILD 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD LDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD KPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD IQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRIN 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD CNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD TGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVT 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD FKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD GNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYI 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD GGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQ 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD EDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTR 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD ADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIIN 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD DGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLD :::::::::::::::::::::::::::::::: XP_016 DGKYHVVRFTRSGGNATLQVDSWPVIERYPAG---------------------------- 1210 1220 1230 1270 1280 1290 1300 1310 1320 pF1KSD KGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 --RQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVG 1240 1250 1260 1270 1280 1290 1330 1340 1350 1360 1370 1380 pF1KSD EVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAEC 1300 1310 1320 1330 1340 1350 1390 1400 1410 1420 1430 1440 pF1KSD PSDDEDIDPCEPSSANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSDDEDIDPCEPSSANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYA 1360 1370 1380 1390 1400 1410 1450 1460 1470 1480 1490 pF1KSD MYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1420 1430 1440 1450 1460 >>NP_004792 (OMIM: 600565,614325,614332) neurexin-1 isof (1477 aa) initn: 8964 init1: 5762 opt: 8317 Z-score: 7742.5 bits: 1445.3 E(85289): 0 Smith-Waterman score: 9716; 97.3% identity (97.3% similar) in 1507 aa overlap (1-1496:1-1477) 10 20 30 40 50 60 pF1KSD MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD AVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG 310 320 330 340 350 360 370 380 390 400 410 pF1KSD KFNDNAWHDVKVTRNLRQ--------VTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSP :::::::::::::::::: :::::::::::::::::::::::::::::::::: NP_004 KFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSP 370 380 390 400 410 420 420 430 440 450 460 470 pF1KSD STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLD 430 440 450 460 470 480 480 490 500 510 520 530 pF1KSD PITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDF 490 500 510 520 530 540 540 550 560 570 580 590 pF1KSD FAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 FAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTA 550 560 570 580 590 600 600 610 620 630 640 650 pF1KSD PGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMA 610 620 630 640 650 660 660 670 680 690 700 710 pF1KSD EVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLS 670 680 690 700 710 720 720 730 740 750 760 770 pF1KSD YDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 YDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTV 730 740 750 760 770 780 780 790 800 810 820 830 pF1KSD NLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 NLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHT 790 800 810 820 830 840 840 850 860 870 880 890 pF1KSD RLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFR 850 860 870 880 890 900 900 910 920 930 940 950 pF1KSD NIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 NIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKG 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KSD YLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 YLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNL 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KSD DLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KSD EGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWP 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KSD PNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAI 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KSD EESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGR :::::::::::::::::::::::::::::::::::::::: NP_004 EESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAG-------------------- 1210 1220 1230 1240 1260 1270 1280 1290 1300 1310 pF1KSD VVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAI :::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ----------RQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAI 1250 1260 1270 1280 1290 1320 1330 1340 1350 1360 1370 pF1KSD VGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDD 1300 1310 1320 1330 1340 1350 1380 1390 1400 1410 1420 pF1KSD ILVASAECPSDDEDIDPCEPSS---ANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAA :::::::::::::::::::::: ::::::::::::::::::::::::::::::::::: NP_004 ILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAA 1360 1370 1380 1390 1400 1410 1430 1440 1450 1460 1470 1480 pF1KSD AALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKN 1420 1430 1440 1450 1460 1470 1490 pF1KSD KDKEYYV ::::::: NP_004 KDKEYYV >>XP_016860815 (OMIM: 600565,614325,614332) PREDICTED: n (1471 aa) initn: 8174 init1: 5762 opt: 8256 Z-score: 7685.7 bits: 1434.8 E(85289): 0 Smith-Waterman score: 9655; 96.9% identity (96.9% similar) in 1507 aa overlap (1-1496:1-1471) 10 20 30 40 50 60 pF1KSD MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD AVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP ::::::::::::::::: ::::::::::::::::::::::::::::::::::::: XP_016 AVCDCSRTGFRGKDCSQ------GLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP 250 260 270 280 290 310 320 330 340 350 360 pF1KSD IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG 300 310 320 330 340 350 370 380 390 400 410 pF1KSD KFNDNAWHDVKVTRNLRQ--------VTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSP :::::::::::::::::: :::::::::::::::::::::::::::::::::: XP_016 KFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSP 360 370 380 390 400 410 420 430 440 450 460 470 pF1KSD STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLD 420 430 440 450 460 470 480 490 500 510 520 530 pF1KSD PITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDF 480 490 500 510 520 530 540 550 560 570 580 590 pF1KSD FAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTA 540 550 560 570 580 590 600 610 620 630 640 650 pF1KSD PGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMA 600 610 620 630 640 650 660 670 680 690 700 710 pF1KSD EVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLS 660 670 680 690 700 710 720 730 740 750 760 770 pF1KSD YDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTV 720 730 740 750 760 770 780 790 800 810 820 830 pF1KSD NLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHT 780 790 800 810 820 830 840 850 860 870 880 890 pF1KSD RLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFR 840 850 860 870 880 890 900 910 920 930 940 950 pF1KSD NIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKG 900 910 920 930 940 950 960 970 980 990 1000 1010 pF1KSD YLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNL 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 pF1KSD DLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 pF1KSD EGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWP 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 pF1KSD PNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAI 1140 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 pF1KSD EESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGR :::::::::::::::::::::::::::::::::::::::: XP_016 EESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAG-------------------- 1200 1210 1220 1230 1260 1270 1280 1290 1300 1310 pF1KSD VVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAI :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ----------RQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAI 1240 1250 1260 1270 1280 1320 1330 1340 1350 1360 1370 pF1KSD VGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDD 1290 1300 1310 1320 1330 1340 1380 1390 1400 1410 1420 pF1KSD ILVASAECPSDDEDIDPCEPSS---ANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAA :::::::::::::::::::::: ::::::::::::::::::::::::::::::::::: XP_016 ILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAA 1350 1360 1370 1380 1390 1400 1430 1440 1450 1460 1470 1480 pF1KSD AALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKN 1410 1420 1430 1440 1450 1460 1490 pF1KSD KDKEYYV ::::::: XP_016 KDKEYYV 1470 1496 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 02:09:37 2016 done: Thu Nov 3 02:09:39 2016 Total Scan time: 12.030 Total Display time: 0.760 Function used was FASTA [36.3.4 Apr, 2011]